hexamidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3275	3811-75-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

hexamidine
desmodine
hexamidine diisethionate
hexamidine isethionate
hexamidine isetionate
hexamidine dihydrochloride
hexamidine hydrochloride
hexamidine HCl
hexomedin

Molecular weight: 354.45
Formula: C20H26N4O2
CLOGP: 2.84
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 118.20
ALOGS: -4.40
ROTB: 11

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AC04	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Biguanides and amidines
ATC	R01AX07	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Other nasal preparations
ATC	R02AA18	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
ATC	S01AX08	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Other antiinfectives
ATC	S03AA05	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives
MeSH PA	D000890	Anti-Infective Agents
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:48218	antiseptics

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acanthamoeba keratitis	indication	231896005

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.38	Basic
pKa2	10.78	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Urokinase-type plasminogen activator	Enzyme	P00749	UROK_HUMAN		Ki	4.84		CHEMBL
Prothrombin	Enzyme	P00734	THRB_HUMAN		Ki	6.65		CHEMBL
Trypsin-1	Enzyme	P07477	TRY1_HUMAN		Ki	5.57		CHEMBL
Suppressor of tumorigenicity 14 protein	Enzyme	Q9Y5Y6	ST14_HUMAN		Ki	6.03		CHEMBL
Protein arginine N-methyltransferase 1	Enzyme	Q99873	ANM1_HUMAN		IC50	4.28		CHEMBL

External reference:

ID	Source
D07206	KEGG_DRUG
CHEBI:87184	CHEBI
DID	PDB_CHEM_ID
CHEMBL25105	ChEMBL_ID
C018961	MESH_SUPPLEMENTAL_RECORD_UI
1393	INN_ID
659-40-5	SECONDARY_CAS_RN
DB03808	DRUGBANK_ID
3483C2H13H	UNII
1939371	RXNORM
005603	NDDF
005604	NDDF
703831002	SNOMEDCT_US
703832009	SNOMEDCT_US
C0062648	UMLSCUI
65130	PUBCHEM_CID

Pharmaceutical products:

None