Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	281	1405-87-4

Description:

Molecule	Description
Synonyms: bacitracin baciguent bacillichin bacilliquin bacitracin zinc bacitracin methylene disalicylate	A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140) Molecular weight: 5648.77 Formula: C261H406N68O64S4 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 530.87 ALOGS: ROTB: None

Molecule

Description

Synonyms:

bacitracin
baciguent
bacillichin
bacilliquin
bacitracin zinc
bacitracin methylene disalicylate

A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)

Molecular weight: 5648.77
Formula: C261H406N68O64S4
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 530.87
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
July 29, 1948	FDA	PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Local anaesthetic systemic toxicity	871.84	9.23	253	77603	3247	90547344
Maternal exposure during delivery	318.07	9.23	121	77735	3725	90546866
Anaphylactic reaction	262.41	9.23	349	77507	87175	90463416
Cardiac arrest	247.38	9.23	373	77483	104562	90446029
Anaphylactic shock	246.89	9.23	210	77646	31407	90519184
Pemphigus	225.28	9.23	14	77842	326850	90223741
Toxic anterior segment syndrome	223.54	9.23	81	77775	2169	90548422
Hand deformity	215.90	9.23	9	77847	296353	90254238
Glossodynia	204.33	9.23	20	77836	321759	90228832
Systemic lupus erythematosus	199.94	9.23	35	77821	361861	90188730
Synovitis	198.02	9.23	25	77831	329727	90220864
Contraindicated product administered	181.17	9.23	29	77827	320110	90230481
Anti-cyclic citrullinated peptide antibody positive	172.79	9.23	7	77849	236426	90314165
Kounis syndrome	171.19	9.23	69	77787	2484	90548107
Pericarditis	163.34	9.23	20	77836	270131	90280460
Duodenal ulcer perforation	160.21	9.23	7	77849	221281	90329310
Hepatic enzyme increased	158.50	9.23	56	77800	360680	90189911
Methaemoglobinaemia	153.30	9.23	73	77783	3942	90546649
Wound	145.68	9.23	40	77816	302940	90247651
Arthropathy	141.32	9.23	69	77787	366173	90184418
Sinusitis	140.24	9.23	625	77231	342463	90208128
Hypotension	139.24	9.23	601	77255	324796	90225795
Joint swelling	138.48	9.23	137	77719	503163	90047428
Infusion site pain	137.76	9.23	123	77733	19615	90530976
Generalised tonic-clonic seizure	133.01	9.23	157	77699	34746	90515845
Folliculitis	128.88	9.23	13	77843	204340	90346251
Helicobacter infection	125.08	9.23	22	77834	226828	90323763
Infusion site swelling	121.65	9.23	92	77764	11628	90538963
Anaesthetic complication	116.58	9.23	52	77804	2413	90548178
Rheumatoid factor positive	116.27	9.23	8	77848	171642	90378949
Stress cardiomyopathy	113.13	9.23	93	77763	13262	90537329
Drug intolerance	111.79	9.23	132	77724	447459	90103132
Insurance issue	111.49	9.23	85	77771	10873	90539718
Liver injury	107.16	9.23	11	77845	170556	90380035
General physical health deterioration	105.50	9.23	90	77766	355025	90195566
Muscle injury	104.52	9.23	14	77842	176640	90373951
Rheumatic fever	104.11	9.23	7	77849	153114	90397477
Infusion site extravasation	102.64	9.23	79	77777	10249	90540342
Pulseless electrical activity	101.41	9.23	74	77782	8858	90541733
Bradycardia	100.06	9.23	222	77634	83625	90466966
Infusion site erythema	99.01	9.23	87	77769	13583	90537008
Abdominal discomfort	98.94	9.23	161	77695	477167	90073424
Impaired healing	98.38	9.23	39	77817	234160	90316431
Infusion site pruritus	97.78	9.23	65	77791	6700	90543891
Psoriatic arthropathy	97.60	9.23	37	77819	228298	90322293
Alopecia	94.41	9.23	176	77680	494895	90055696
Blister	92.46	9.23	52	77804	254946	90295645
Urinary tract infection	91.56	9.23	510	77346	305122	90245469
Seizure	82.11	9.23	303	77553	152326	90398265
COVID-19	81.65	9.23	324	77532	168519	90382072
Sleep disorder due to general medical condition, insomnia type	81.62	9.23	8	77848	128686	90421905
Illness	79.30	9.23	200	77656	81769	90468822
Type 2 diabetes mellitus	78.77	9.23	38	77818	203206	90347385
Therapeutic product effect decreased	76.87	9.23	75	77781	277496	90273095
Infusion site haemorrhage	75.82	9.23	51	77805	5360	90545231
Procedural hypotension	73.27	9.23	33	77823	1567	90549024
Toxicity to various agents	73.10	9.23	460	77396	287386	90263205
Infusion site bruising	73.01	9.23	46	77810	4326	90546265
Mobility decreased	72.67	9.23	65	77791	250669	90299922
Swollen joint count increased	70.29	9.23	7	77849	111199	90439392
Irritable bowel syndrome	70.03	9.23	46	77810	207402	90343189
Pulse absent	68.37	9.23	50	77806	6005	90544586
Facet joint syndrome	68.36	9.23	4	77852	98385	90452206
Ill-defined disorder	68.02	9.23	37	77819	184854	90365737
Product dose omission issue	66.67	9.23	454	77402	291233	90259358
Corneal oedema	64.85	9.23	32	77824	1869	90548722
Lip dry	64.74	9.23	6	77850	100949	90449642
C-reactive protein abnormal	64.71	9.23	15	77841	127414	90423177
Anaesthetic complication neurological	63.75	9.23	24	77832	717	90549874
Apnoea	62.41	9.23	57	77799	9357	90541234
Swelling	61.19	9.23	172	77684	418886	90131705
Incorrect drug administration rate	60.95	9.23	44	77812	5179	90545412
Musculoskeletal stiffness	60.46	9.23	101	77755	296431	90254160
Sulphaemoglobinaemia	59.80	9.23	21	77835	512	90550079
Bronchitis	59.66	9.23	275	77581	152652	90397939
Lower respiratory tract infection	59.27	9.23	77	77779	250582	90300009
Seasonal allergy	58.86	9.23	85	77771	22898	90527693
Staphylococcal infection	58.61	9.23	129	77727	48310	90502281
Hypersensitivity	58.31	9.23	198	77658	454479	90096112
Mental status changes	56.36	9.23	121	77735	44558	90506033
Unresponsive to stimuli	56.07	9.23	110	77746	38011	90512580
Systemic toxicity	55.87	9.23	17	77839	259	90550332
Rheumatoid arthritis	55.81	9.23	145	77711	362469	90188122
Ventricular tachycardia	55.58	9.23	86	77770	24622	90525969
Respiratory tract infection	54.91	9.23	142	77714	58936	90491655
Product adhesion issue	54.78	9.23	41	77815	5101	90545490
Fear	53.99	9.23	69	77787	16553	90534038
Peripheral venous disease	53.78	9.23	5	77851	83916	90466675
Bursitis	53.52	9.23	23	77833	131631	90418960
Ventricular fibrillation	53.21	9.23	63	77793	13981	90536610
Infusion site urticaria	53.00	9.23	27	77829	1688	90548903
Emotional distress	52.96	9.23	105	77751	36557	90514034
Upper respiratory tract infection	51.72	9.23	233	77623	128085	90422506
Inflammation	50.89	9.23	47	77809	178545	90372046
Extradural abscess	50.67	9.23	24	77832	1280	90549311
Dermatitis contact	49.89	9.23	60	77796	13535	90537056
Blood cholesterol increased	49.07	9.23	64	77792	207948	90342643
Extradural haematoma	48.25	9.23	27	77829	2041	90548550
Sleep disorder	47.67	9.23	60	77796	197970	90352621
Gait inability	47.38	9.23	34	77822	146422	90404169
Completed suicide	46.51	9.23	34	77822	145024	90405567
Drug ineffective for unapproved indication	46.12	9.23	144	77712	66500	90484091
Neurotoxicity	45.90	9.23	73	77783	21394	90529197
Obesity	45.22	9.23	17	77839	105490	90445101
Stomatitis	44.46	9.23	107	77749	274591	90276000
Inappropriate schedule of product administration	44.03	9.23	249	77607	149684	90400907
Administration site pain	43.51	9.23	21	77835	1168	90549423
Lagophthalmos	43.21	9.23	16	77840	456	90550135
Anterior chamber cell	42.91	9.23	18	77838	718	90549873
Peripheral nerve injury	42.84	9.23	18	77838	721	90549870
Treatment failure	41.96	9.23	128	77728	303800	90246791
Infusion site mass	41.57	9.23	25	77831	2164	90548427
Status epilepticus	41.48	9.23	65	77791	18809	90531782
Ear infection	41.32	9.23	143	77713	69632	90480959
Liver disorder	40.76	9.23	27	77829	121242	90429349
Endophthalmitis	40.46	9.23	33	77823	4652	90545939
Type I hypersensitivity	39.58	9.23	31	77825	4124	90546467
Grip strength decreased	39.54	9.23	15	77841	92561	90458030
Tachycardia	39.36	9.23	251	77605	157422	90393169
Unevaluable event	39.33	9.23	120	77736	54728	90495863
Hypopyon	39.17	9.23	18	77838	896	90549695
Premature delivery	38.97	9.23	96	77760	38666	90511925
Embolia cutis medicamentosa	38.41	9.23	16	77840	627	90549964
Spinal epidural haematoma	38.34	9.23	20	77836	1314	90549277
Bronchospasm	38.33	9.23	66	77790	20643	90529948
Spinal epidural haemorrhage	38.19	9.23	13	77843	288	90550303
Adjustment disorder with depressed mood	37.40	9.23	3	77853	56750	90493841
Renal injury	37.25	9.23	45	77811	10198	90540393
Infusion related reaction	36.68	9.23	209	77647	416571	90134020
Deep vein thrombosis postoperative	36.62	9.23	8	77848	70801	90479790
Fibromyalgia	36.09	9.23	77	77779	206192	90344399
Abdominal pain upper	36.07	9.23	155	77701	332519	90218072
Bursitis infective	36.01	9.23	20	77836	1490	90549101
Prescribed underdose	35.83	9.23	10	77846	75009	90475582
Pneumocephalus	35.63	9.23	12	77844	257	90550334
Headache	35.28	9.23	980	76876	861766	89688825
Anhedonia	34.86	9.23	46	77810	11385	90539206
Kidney infection	34.79	9.23	72	77784	25844	90524747
Respiratory depression	34.73	9.23	54	77802	15521	90535070
Product use issue	34.38	9.23	156	77700	329763	90220828
Infusion site discharge	34.24	9.23	23	77833	2412	90548179
Infusion site rash	33.83	9.23	23	77833	2460	90548131
Condition aggravated	33.70	9.23	338	77518	595207	89955384
Paraplegia	33.69	9.23	26	77830	3386	90547205
Pulmonary fibrosis	33.43	9.23	26	77830	107477	90443114
C-reactive protein increased	33.18	9.23	66	77790	181323	90369268
Multiple allergies	33.06	9.23	52	77804	15094	90535497
Vascular malformation	32.82	9.23	15	77841	737	90549854
Musculoskeletal pain	32.46	9.23	61	77795	171190	90379401
Sinus tachycardia	32.33	9.23	74	77782	28439	90522152
Cauda equina syndrome	32.31	9.23	18	77838	1349	90549242
Chills	32.26	9.23	209	77647	131772	90418819
Confusional state	32.21	9.23	197	77659	386008	90164583
Vitritis	32.12	9.23	19	77837	1595	90548996
Nail disorder	31.95	9.23	6	77850	59061	90491530
Paranasal cyst	31.76	9.23	15	77841	795	90549796
Stridor	31.73	9.23	29	77827	4764	90545827
Wheezing	31.63	9.23	102	77754	237978	90312613
Prescribed overdose	31.13	9.23	23	77833	97602	90452989
Spinal cord compression	31.13	9.23	29	77827	4882	90545709
Anal skin tags	31.06	9.23	14	77842	666	90549925
Infusion site nodule	30.98	9.23	19	77837	1704	90548887
Meningitis chemical	30.80	9.23	11	77845	282	90550309
Hypercholesterolaemia	30.62	9.23	25	77831	100867	90449724
Parophthalmia	30.33	9.23	12	77844	411	90550180
Osteoarthritis	30.28	9.23	78	77778	195652	90354939
Discomfort	30.23	9.23	127	77729	274208	90276383
Eyelid ptosis	30.22	9.23	38	77818	8968	90541623
Arthralgia	30.15	9.23	479	77377	778043	89772548
Fear of eating	30.09	9.23	12	77844	420	90550171
Knee arthroplasty	30.07	9.23	17	77839	83165	90467426
Epidural haemorrhage	30.06	9.23	11	77845	303	90550288
Back pain	29.72	9.23	409	77447	316766	90233825
Hypoxia	29.56	9.23	132	77724	72267	90478324
Cardiogenic shock	29.41	9.23	65	77791	24403	90526188
Purtscher retinopathy	29.35	9.23	9	77847	141	90550450
Stress	29.27	9.23	143	77713	81252	90469339
Blepharospasm	29.21	9.23	6	77850	55439	90495152
Wound infection	29.14	9.23	29	77827	106373	90444218
Night sweats	28.96	9.23	41	77815	128725	90421866
Lung disorder	28.75	9.23	53	77803	149830	90400761
Joint range of motion decreased	28.74	9.23	45	77811	135598	90414993
Corneal epithelium defect	28.60	9.23	12	77844	479	90550112
Localised infection	28.48	9.23	78	77778	33484	90517107
Hip arthroplasty	28.38	9.23	15	77841	76193	90474398
Ophthalmoplegia	28.20	9.23	18	77838	1731	90548860
Administration site swelling	28.16	9.23	17	77839	1482	90549109
Anxiety	28.03	9.23	397	77459	309375	90241216
Myelosuppression	27.82	9.23	6	77850	53585	90497006
Bundle branch block left	27.63	9.23	34	77822	7851	90542740
Platelet aggregation inhibition	27.30	9.23	9	77847	180	90550411
Septic arthritis staphylococcal	26.74	9.23	12	77844	565	90550026
Aqueous fibrin	26.72	9.23	8	77848	115	90550476
Incorrect route of product administration	25.95	9.23	99	77757	50527	90500064
Therapy partial responder	25.87	9.23	58	77798	21985	90528606
Medical device site cellulitis	25.72	9.23	9	77847	217	90550374
Haemorrhoids	25.65	9.23	65	77791	26637	90523954
Skin infection	25.60	9.23	51	77805	17813	90532778
Bone erosion	25.45	9.23	7	77849	53014	90497577
Drug-induced liver injury	25.45	9.23	24	77832	90294	90460297
Circulatory collapse	25.37	9.23	62	77794	24842	90525749
Trigeminal palsy	25.26	9.23	7	77849	75	90550516
Retinal vasculitis	25.20	9.23	16	77840	1525	90549066
Body tinea	24.85	9.23	18	77838	2130	90548461
Hepatitis	24.80	9.23	15	77841	70724	90479867
Diplopia	24.63	9.23	67	77789	28647	90521944
Dry mouth	24.34	9.23	79	77777	183980	90366611
Epidural analgesia	24.13	9.23	8	77848	163	90550428
Procedure aborted	23.90	9.23	8	77848	168	90550423
Colitis ulcerative	23.75	9.23	11	77845	60255	90490336
Ventricular hypokinesia	23.69	9.23	26	77830	5315	90545276
Foetal heart rate abnormal	23.65	9.23	13	77843	949	90549642
Post procedural complication	23.36	9.23	51	77805	18991	90531600
Otitis media	23.35	9.23	27	77829	5843	90544748
Gastroenteritis viral	23.26	9.23	68	77788	30287	90520304
Red blood cell sedimentation rate increased	23.21	9.23	22	77834	82573	90468018
Punctate keratitis	23.06	9.23	12	77844	784	90549807
Adverse event	22.98	9.23	41	77815	117377	90433214
Viral infection	22.90	9.23	83	77773	41331	90509260
Infusion site discomfort	22.81	9.23	16	77840	1800	90548791
Upper airway obstruction	22.80	9.23	13	77843	1019	90549572
Hepatic cirrhosis	22.76	9.23	13	77843	63240	90487351
Nephrolithiasis	22.74	9.23	93	77763	48992	90501599
Visual acuity reduced	22.50	9.23	57	77799	23353	90527238
Medical device site abscess	22.48	9.23	8	77848	203	90550388
Infusion site warmth	22.39	9.23	17	77839	2161	90548430
Neuromuscular block prolonged	22.31	9.23	11	77845	641	90549950
Onychomadesis	22.21	9.23	6	77850	45992	90504599
Loss of personal independence in daily activities	22.02	9.23	53	77803	136052	90414539
Cellulitis	21.92	9.23	144	77712	91193	90459398
Nystagmus	21.91	9.23	29	77827	7198	90543393
Peripheral swelling	21.89	9.23	238	77618	412868	90137723
Product distribution issue	21.81	9.23	21	77835	3684	90546907
Ventricular extrasystoles	21.66	9.23	40	77816	13210	90537381
Mastoiditis	21.64	9.23	15	77841	1655	90548936
Chemical burn	21.62	9.23	10	77846	505	90550086
Lupus vulgaris	21.53	9.23	6	77850	45053	90505538
Frequent bowel movements	21.51	9.23	11	77845	56924	90493667
Foetal exposure during delivery	21.18	9.23	9	77847	371	90550220
Vitamin D increased	21.12	9.23	12	77844	934	90549657
Nerve root injury	21.11	9.23	6	77850	71	90550520
Atonic urinary bladder	20.74	9.23	7	77849	151	90550440
Hypoaesthesia oral	20.54	9.23	43	77813	15557	90535034
Airway peak pressure increased	20.35	9.23	9	77847	409	90550182
Gastrointestinal disorder	20.32	9.23	133	77723	256554	90294037
Poor venous access	20.31	9.23	49	77807	19478	90531113
Meningitis aseptic	20.26	9.23	27	77829	6746	90543845
Tinnitus	20.24	9.23	82	77774	43020	90507571
Spinal anaesthesia	20.19	9.23	6	77850	84	90550507
Monoplegia	20.09	9.23	20	77836	3654	90546937
Hyperthermia malignant	20.04	9.23	13	77843	1285	90549306
Procedural complication	20.04	9.23	25	77831	5853	90544738
Sepsis	19.83	9.23	239	77617	179575	90371016
Psoriasis	19.83	9.23	63	77793	147691	90402900
Infusion site discolouration	19.56	9.23	12	77844	1077	90549514
Normal newborn	19.53	9.23	54	77802	23308	90527283
Bacterial infection	19.41	9.23	54	77802	23390	90527201
Nerve block	19.39	9.23	11	77845	854	90549737
Tremor	19.32	9.23	209	77647	152964	90397627
Paralysis	19.20	9.23	35	77821	11443	90539148
Vocal cord dysfunction	18.82	9.23	11	77845	903	90549688
Pulmonary oedema	18.81	9.23	104	77752	61976	90488615
Cardio-respiratory arrest	18.61	9.23	105	77751	63035	90487556
Vasoplegia syndrome	18.58	9.23	17	77839	2797	90547794
Blood pressure decreased	18.54	9.23	119	77737	74776	90475815
Tenderness	18.53	9.23	58	77798	26810	90523781
Arthritis bacterial	18.28	9.23	27	77829	7418	90543173
Vascular stenosis	18.22	9.23	9	77847	527	90550064
Mydriasis	18.18	9.23	40	77816	14972	90535619
Vaginal abscess	18.12	9.23	9	77847	533	90550058
Nail bed tenderness	17.96	9.23	8	77848	370	90550221
Heliotrope rash	17.74	9.23	7	77849	238	90550353
Autoimmune disorder	17.69	9.23	24	77832	76720	90473871
Transferrin decreased	17.56	9.23	8	77848	390	90550201
Tachypnoea	17.56	9.23	49	77807	21260	90529331
Retinal artery occlusion	17.55	9.23	15	77841	2256	90548335
Haemodynamic instability	17.41	9.23	34	77822	11705	90538886
Product use in unapproved indication	17.24	9.23	394	77462	335842	90214749
Infection susceptibility increased	17.22	9.23	19	77837	3907	90546684
Retinal detachment	17.13	9.23	25	77831	6797	90543794
Cystitis	17.13	9.23	107	77749	66611	90483980
Blood pressure abnormal	17.01	9.23	46	77810	19599	90530992
Nausea	16.95	9.23	1138	76718	1109178	89441413
Left ventricle outflow tract obstruction	16.94	9.23	8	77848	424	90550167
Influenza like illness	16.93	9.23	123	77733	80488	90470103
Inhibitory drug interaction	16.89	9.23	17	77839	3146	90547445
Underdose	16.87	9.23	13	77843	54004	90496587
Electrocardiogram ST segment elevation	16.87	9.23	19	77837	3997	90546594
Anaphylactoid shock	16.83	9.23	8	77848	430	90550161
Retinitis	16.81	9.23	6	77850	38452	90512139
Drug interaction	16.77	9.23	332	77524	276121	90274470
Skin discolouration	16.75	9.23	79	77777	44236	90506355
Eye infarction	16.63	9.23	5	77851	73	90550518
Inadequate analgesia	16.62	9.23	17	77839	3207	90547384
Drug reaction with eosinophilia and systemic symptoms	16.54	9.23	8	77848	42750	90507841
Spinal synovial cyst	16.44	9.23	5	77851	76	90550515
Intercepted medication error	16.40	9.23	10	77846	887	90549704
Iron binding capacity total decreased	16.36	9.23	8	77848	458	90550133
Loss of consciousness	16.17	9.23	188	77668	140050	90410541
Vision blurred	16.06	9.23	155	77701	110138	90440453
Quadriparesis	16.06	9.23	15	77841	2534	90548057
Apgar score low	16.05	9.23	11	77845	1192	90549399
Poikiloderma	15.98	9.23	7	77849	311	90550280
Nasal mucosal disorder	15.87	9.23	13	77843	1844	90548747
Acute respiratory failure	15.85	9.23	76	77780	42842	90507749
Administration site extravasation	15.83	9.23	11	77845	1219	90549372
Epilepsy	15.82	9.23	29	77827	82177	90468414
Conjunctival oedema	15.69	9.23	10	77846	959	90549632
Brain stem syndrome	15.67	9.23	9	77847	715	90549876
Abortion spontaneous	15.66	9.23	14	77842	54042	90496549
Anorectal discomfort	15.64	9.23	16	77840	3018	90547573
Limb injury	15.64	9.23	61	77795	31447	90519144
Therapeutic product effect incomplete	15.57	9.23	100	77756	193796	90356795
Weight increased	15.51	9.23	259	77597	417668	90132923
Apnoeic attack	15.47	9.23	7	77849	336	90550255
Anal sphincter atony	15.47	9.23	7	77849	336	90550255
Asthenia	15.47	9.23	345	77511	533406	90017185
Allergy to immunoglobulin therapy	15.40	9.23	6	77850	197	90550394
Incontinence	15.37	9.23	35	77821	13400	90537191
Sinusitis bacterial	15.35	9.23	13	77843	1930	90548661
Peripheral vascular disorder	15.33	9.23	23	77833	6408	90544183
Sensory loss	15.32	9.23	42	77814	18033	90532558
C-reactive protein	15.32	9.23	4	77852	31363	90519228
Anaphylactoid reaction	15.23	9.23	19	77837	4449	90546142
Cancer pain	15.16	9.23	18	77838	4007	90546584
Delayed recovery from anaesthesia	15.14	9.23	10	77846	1020	90549571
Agitation	15.03	9.23	104	77752	66994	90483597
Eyelid contusion	15.03	9.23	5	77851	103	90550488
Wrong product administered	14.94	9.23	25	77831	7640	90542951
Orbital infection	14.64	9.23	5	77851	112	90550479
Infusion site streaking	14.62	9.23	8	77848	579	90550012
Akinesia	14.52	9.23	12	77844	1724	90548867
Influenza	14.44	9.23	183	77673	139081	90411510
Cough	14.41	9.23	417	77439	368545	90182046
Respiratory distress	14.41	9.23	69	77787	38877	90511714
Streptococcal infection	14.40	9.23	24	77832	7309	90543282
Infusion site scar	14.38	9.23	8	77848	598	90549993
Electrocardiogram QRS complex prolonged	14.37	9.23	24	77832	7324	90543267
Autonomic neuropathy	14.36	9.23	11	77845	1416	90549175
Tooth infection	14.34	9.23	44	77812	20126	90530465
Procedural anxiety	14.28	9.23	9	77847	847	90549744
Body dysmorphic disorder	14.26	9.23	7	77849	404	90550187
Glucose tolerance impaired	14.19	9.23	25	77831	7960	90542631
Nail bed inflammation	14.13	9.23	12	77844	1789	90548802
Diplegia	14.04	9.23	11	77845	1464	90549127
Implant site bruising	14.02	9.23	7	77849	419	90550172
Neonatal toxicity	14.02	9.23	4	77852	48	90550543
Axillary nerve injury	13.95	9.23	4	77852	49	90550542
Anterior chamber fibrin	13.90	9.23	5	77851	131	90550460
Infusion site oedema	13.90	9.23	10	77846	1171	90549420
Obstruction	13.89	9.23	17	77839	3904	90546687
Intentional self-injury	13.84	9.23	4	77852	29330	90521261
Administration site erythema	13.78	9.23	9	77847	900	90549691
Respiratory failure	13.76	9.23	159	77697	118259	90432332
Proctalgia	13.72	9.23	25	77831	8173	90542418
Thrombocytopenia	13.70	9.23	114	77742	208611	90341980
Vascular resistance systemic decreased	13.65	9.23	5	77851	138	90550453
Gastric mucosa erythema	13.60	9.23	7	77849	447	90550144
Coeliac disease	13.60	9.23	11	77845	44599	90505992
Back injury	13.59	9.23	12	77844	46610	90503981
Calcinosis	13.51	9.23	14	77842	2681	90547910
Cholestasis of pregnancy	13.39	9.23	11	77845	1566	90549025
Neuralgia	13.28	9.23	58	77798	31442	90519149
Product preparation error	13.18	9.23	28	77828	10233	90540358
Spinal stroke	13.14	9.23	4	77852	61	90550530
Productive cough	13.10	9.23	112	77744	76951	90473640
Varicose vein	13.10	9.23	23	77833	7304	90543287
Multiple organ dysfunction syndrome	13.07	9.23	102	77754	68234	90482357
Eclampsia	12.99	9.23	7	77849	491	90550100
Economic problem	12.90	9.23	15	77841	3266	90547325
Papule	12.88	9.23	24	77832	7978	90542613
Retinal haemorrhage	12.87	9.23	20	77836	5744	90544847
Pneumonia mycoplasmal	12.83	9.23	9	77847	1013	90549578
Metapneumovirus infection	12.80	9.23	10	77846	1325	90549266
Arthritis fungal	12.79	9.23	4	77852	67	90550524
Immunodeficiency	12.76	9.23	11	77845	43223	90507368
Sinus disorder	12.72	9.23	61	77795	34386	90516205
Infusion site irritation	12.68	9.23	10	77846	1343	90549248
Allergy to metals	12.68	9.23	9	77847	1031	90549560
Heparin-induced thrombocytopenia	12.67	9.23	19	77837	5293	90545298
Myocardial ischaemia	12.62	9.23	33	77823	13781	90536810
Cyanosis	12.51	9.23	41	77815	19414	90531177
Erythema	12.49	9.23	271	77585	228975	90321616
Labelled drug-drug interaction medication error	12.48	9.23	34	77822	14548	90536043
Intraocular pressure fluctuation	12.48	9.23	4	77852	73	90550518
Genital ulceration	12.43	9.23	9	77847	1064	90549527
Hordeolum	12.43	9.23	18	77838	4860	90545731
Memory impairment	12.38	9.23	109	77747	197135	90353456
Trigemino-cardiac reflex	12.37	9.23	4	77852	75	90550516
Macular oedema	12.34	9.23	18	77838	4891	90545700
Somnolence	12.31	9.23	250	77606	208834	90341757
Cataract nuclear	12.27	9.23	9	77847	1085	90549506
Haemangioma congenital	12.27	9.23	7	77849	549	90550042
Phrenic nerve paralysis	12.26	9.23	6	77850	344	90550247
Fear-related avoidance of activities	12.25	9.23	5	77851	186	90550405
Dyspepsia	12.22	9.23	110	77746	198050	90352541
Tooth disorder	12.18	9.23	56	77800	31034	90519557
Spinal cord injury	12.16	9.23	9	77847	1100	90549491
Tryptase increased	12.14	9.23	7	77849	560	90550031
Implant site swelling	12.09	9.23	7	77849	565	90550026
Injection site abscess	12.05	9.23	10	77846	1444	90549147
Haematocrit increased	11.98	9.23	14	77842	3064	90547527
Hepatotoxicity	11.98	9.23	13	77843	45829	90504762
Lethargy	11.94	9.23	94	77762	63045	90487546
Injection site atrophy	11.93	9.23	8	77848	836	90549755
Quadriplegia	11.93	9.23	12	77844	2219	90548372
Renal failure	11.87	9.23	168	77688	130839	90419752
Accelerated idioventricular rhythm	11.78	9.23	4	77852	88	90550503
Post procedural infection	11.74	9.23	28	77828	11046	90539545
Sciatica	11.74	9.23	46	77810	101336	90449255
Product contamination	11.64	9.23	9	77847	1175	90549416
Repetitive strain injury	11.63	9.23	5	77851	212	90550379
Speech disorder	11.63	9.23	73	77783	45512	90505079
Drug level increased	11.62	9.23	51	77805	27711	90522880
Mean arterial pressure decreased	11.61	9.23	5	77851	213	90550378
Taste disorder	11.59	9.23	22	77834	61524	90489067
Lower limb fracture	11.58	9.23	36	77820	84977	90465614
Product administration interrupted	11.57	9.23	30	77826	12462	90538129
Retinal cyst	11.41	9.23	4	77852	97	90550494
Application site alopecia	11.30	9.23	3	77853	27	90550564
Cardiotoxicity	11.23	9.23	28	77828	11361	90539230
Pharyngitis streptococcal	11.20	9.23	30	77826	12712	90537879
Muscle tightness	11.17	9.23	31	77825	13408	90537183
Overdose	11.15	9.23	194	77662	157515	90393076
Infusion related hypersensitivity reaction	11.14	9.23	7	77849	655	90549936
Spinal osteoarthritis	11.12	9.23	39	77817	19109	90531482
Haemorrhagic vasculitis	11.11	9.23	4	77852	105	90550486
Central pain syndrome	11.06	9.23	7	77849	663	90549928
Oropharyngeal pain	10.96	9.23	149	77707	115038	90435553
Hallucination, tactile	10.94	9.23	6	77850	436	90550155
Leukopenia	10.85	9.23	47	77809	100663	90449928
Poor quality sleep	10.82	9.23	46	77810	24647	90525944
Corneal abrasion	10.80	9.23	9	77847	1307	90549284
Vasospasm	10.79	9.23	8	77848	981	90549610
Myelitis	10.79	9.23	11	77845	2067	90548524
Anorgasmia	10.78	9.23	7	77849	693	90549898
Orthostatic hypotension	10.78	9.23	12	77844	41815	90508776
Cerebral congestion	10.77	9.23	4	77852	115	90550476
Sympathectomy	10.76	9.23	3	77853	33	90550558
Coccygectomy	10.76	9.23	3	77853	33	90550558
White blood cell disorder	10.74	9.23	13	77843	2951	90547640
Meningitis	10.73	9.23	23	77833	8458	90542133
Arthritis	10.70	9.23	92	77764	167223	90383368
Concussion	10.65	9.23	27	77829	11064	90539527
Liver function test abnormal	10.64	9.23	17	77839	50828	90499763
Pupillary reflex impaired	10.62	9.23	12	77844	2533	90548058
Pupil fixed	10.57	9.23	11	77845	2117	90548474
Meningoencephalitis bacterial	10.57	9.23	5	77851	266	90550325
Moraxella infection	10.55	9.23	6	77850	468	90550123
Conduction disorder	10.53	9.23	10	77846	1725	90548866
Onychomycosis	10.45	9.23	10	77846	37366	90513225
Encephalopathy	10.41	9.23	72	77784	46372	90504219
Body temperature abnormal	10.35	9.23	12	77844	2603	90547988
Incision site swelling	10.35	9.23	5	77851	279	90550312
Spondylolisthesis	10.33	9.23	15	77841	4060	90546531
Product contamination microbial	10.31	9.23	5	77851	281	90550310
Lymphatic disorder	10.31	9.23	6	77850	489	90550102
Incision site rash	10.30	9.23	3	77853	39	90550552
Laryngeal oedema	10.29	9.23	20	77836	6861	90543730
Device infusion issue	10.18	9.23	12	77844	2650	90547941
Inability to afford medication	10.17	9.23	14	77842	3608	90546983
Liver function test increased	10.15	9.23	38	77818	84817	90465774
Fungal infection	10.08	9.23	67	77789	42594	90507997
Impaired quality of life	10.06	9.23	43	77813	23101	90527490
Supraventricular extrasystoles	10.05	9.23	17	77839	5240	90545351
Eye infection	10.04	9.23	31	77825	14223	90536368
Road traffic accident	9.98	9.23	53	77803	107573	90443018
Ischaemia	9.96	9.23	17	77839	5278	90545313
Interstitial lung disease	9.95	9.23	33	77823	76372	90474219
Renal cyst	9.91	9.23	29	77827	12921	90537670
Neurogenic shock	9.86	9.23	6	77850	530	90550061
Allergic cough	9.86	9.23	8	77848	1120	90549471
Clostridium difficile infection	9.85	9.23	59	77797	36186	90514405
Anaesthetic complication cardiac	9.72	9.23	3	77853	48	90550543
Drug tolerance decreased	9.70	9.23	8	77848	32122	90518469
Retrograde amnesia	9.68	9.23	6	77850	548	90550043
Parainfluenzae virus infection	9.68	9.23	12	77844	2791	90547800
Myelitis transverse	9.68	9.23	9	77847	1511	90549080
Carbon dioxide decreased	9.67	9.23	12	77844	2796	90547795
Small intestinal obstruction	9.65	9.23	40	77816	21194	90529397
Fanconi syndrome	9.57	9.23	10	77846	1933	90548658
Femoral nerve injury	9.50	9.23	3	77853	52	90550539
Infusion site induration	9.49	9.23	9	77847	1550	90549041
Foetal death	9.46	9.23	3	77853	20720	90529871
Tooth discolouration	9.44	9.23	8	77848	1190	90549401
Immune thrombocytopenia	9.41	9.23	29	77827	13297	90537294
Hypoaesthesia	9.40	9.23	202	77654	314008	90236583
Administration site reaction	9.36	9.23	5	77851	345	90550246
Osteomyelitis	9.35	9.23	48	77808	27798	90522793
Disseminated intravascular coagulation	9.34	9.23	40	77816	21498	90529093
Orbital oedema	9.30	9.23	5	77851	349	90550242
Eye movement disorder	9.25	9.23	18	77838	6180	90544411
Familial periodic paralysis	9.23	9.23	4	77852	173	90550418

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Local anaesthetic systemic toxicity	522.29	11.13	163	45709	2137	42573326
Anaphylactic shock	234.93	11.13	198	45674	23319	42552144
Anaphylactic reaction	226.47	11.13	254	45618	42489	42532974
Methaemoglobinaemia	198.17	11.13	105	45767	5669	42569794
Inspiratory capacity decreased	174.52	11.13	78	45794	2889	42572574
Cardiac arrest	142.21	11.13	343	45529	108977	42466486
Anaesthetic complication	124.70	11.13	50	45822	1407	42574056
Hypotension	111.79	11.13	560	45312	257071	42318392
Toxic anterior segment syndrome	105.51	11.13	44	45828	1372	42574091
Toxicity to various agents	103.58	11.13	504	45368	228632	42346831
Injury	98.78	11.13	121	45751	22195	42553268
Fear	96.67	11.13	86	45786	10879	42564584
Ventricular tachycardia	95.75	11.13	139	45733	30021	42545442
Bradycardia	86.24	11.13	244	45628	85240	42490223
Ventricular fibrillation	85.86	11.13	132	45740	29991	42545472
Renal injury	82.77	11.13	83	45789	12197	42563266
Emotional distress	80.69	11.13	93	45779	16000	42559463
Generalised tonic-clonic seizure	80.01	11.13	119	45753	26260	42549203
Anhedonia	79.72	11.13	66	45806	7574	42567889
Drug ineffective	75.74	11.13	1020	44852	629177	41946286
Unresponsive to stimuli	63.41	11.13	118	45754	31285	42544178
Sinusitis	60.97	11.13	148	45724	47144	42528319
Electrocardiogram ST segment elevation	57.21	11.13	49	45823	5890	42569573
Tachycardia	55.72	11.13	236	45636	100851	42474612
Stress	51.37	11.13	133	45739	44079	42531384
Infusion site extravasation	48.33	11.13	43	45829	5438	42570025
Anal inflammation	48.19	11.13	30	45842	2199	42573264
Drug ineffective for unapproved indication	47.72	11.13	133	45739	46030	42529433
Unevaluable event	47.10	11.13	110	45762	34178	42541285
Interstitial lung disease	43.58	11.13	15	45857	78447	42497016
Pain	43.39	11.13	428	45444	244420	42331043
Hyperthermia malignant	43.37	11.13	30	45842	2628	42572835
Infusion site pain	43.02	11.13	40	45832	5355	42570108
Incorrect route of product administration	42.55	11.13	86	45786	24219	42551244
Insurance issue	41.78	11.13	35	45837	4081	42571382
Adulterated product	41.44	11.13	19	45853	747	42574716
Overdose	41.44	11.13	223	45649	105041	42470422
SARS-CoV-2 test negative	38.65	11.13	24	45848	1751	42573712
Accident	38.49	11.13	41	45831	6462	42569001
Hypoxia	38.49	11.13	163	45709	69623	42505840
Cardiogenic shock	38.14	11.13	104	45768	35536	42539927
Trigemino-cardiac reflex	36.20	11.13	14	45858	357	42575106
Status epilepticus	35.87	11.13	62	45810	15516	42559947
Electrocardiogram QRS complex prolonged	34.98	11.13	37	45835	5786	42569677
Spinal cord infarction	34.41	11.13	16	45856	650	42574813
Sinus tachycardia	33.71	11.13	71	45801	20582	42554881
Ear infection	33.55	11.13	54	45818	12750	42562713
Infusion site erythema	33.10	11.13	29	45843	3593	42571870
Haemodynamic instability	32.96	11.13	53	45819	12504	42562959
Diarrhoea	32.66	11.13	328	45544	460521	42114942
Mydriasis	31.66	11.13	43	45829	8727	42566736
Cauda equina syndrome	31.32	11.13	17	45855	963	42574500
Neurotoxicity	30.45	11.13	74	45798	23577	42551886
Tracheitis	30.39	11.13	17	45855	1022	42574441
Anaesthetic complication neurological	29.91	11.13	15	45857	721	42574742
Proctalgia	29.04	11.13	37	45835	7056	42568407
Oculocardiac reflex	28.96	11.13	9	45863	116	42575347
Seizure	28.71	11.13	225	45647	120336	42455127
Bronchospasm	28.01	11.13	50	45822	12835	42562628
Apnoea	27.77	11.13	38	45834	7765	42567698
Respiratory tract infection bacterial	27.57	11.13	20	45852	1889	42573574
Respiratory depression	26.42	11.13	61	45811	18807	42556656
Chemical burn	26.40	11.13	11	45861	342	42575121
Negative pressure pulmonary oedema	26.17	11.13	13	45859	612	42574851
Acute kidney injury	26.17	11.13	261	45611	367076	42208387
Blood phosphorus increased	25.19	11.13	47	45825	12478	42562985
Kounis syndrome	25.00	11.13	24	45848	3344	42572119
Accidental overdose	24.85	11.13	77	45795	28253	42547210
Respiratory tract infection	24.45	11.13	73	45799	26249	42549214
Brain oedema	24.21	11.13	54	45818	16273	42559190
Psoriasis	24.18	11.13	11	45861	48593	42526870
Hyperphosphataemia	23.94	11.13	47	45825	12957	42562506
Vasoplegia syndrome	23.75	11.13	21	45851	2634	42572829
Mental status changes	23.70	11.13	99	45773	42016	42533447
Retinal artery occlusion	22.83	11.13	19	45853	2196	42573267
Appendicolith	22.82	11.13	47	45825	13409	42562054
Neuralgia	22.76	11.13	70	45802	25577	42549886
Disease progression	22.63	11.13	79	45793	143577	42431886
Product adhesion issue	22.38	11.13	17	45855	1722	42573741
Brain stem syndrome	22.35	11.13	12	45860	665	42574798
Cytomegalovirus infection	22.13	11.13	4	45868	32302	42543161
Infusion site swelling	21.72	11.13	22	45850	3270	42572193
Decreased appetite	21.48	11.13	121	45751	193016	42382447
Circulatory collapse	21.43	11.13	65	45807	23571	42551892
Tubulointerstitial nephritis	21.41	11.13	4	45868	31544	42543919
Myasthenia gravis	21.32	11.13	51	45821	16086	42559377
Diabetes insipidus	21.25	11.13	23	45849	3690	42571773
Weight decreased	21.16	11.13	134	45738	207814	42367649
Type I hypersensitivity	21.13	11.13	18	45854	2148	42573315
Drug therapy	21.11	11.13	30	45842	6350	42569113
Respiratory tract infection viral	21.09	11.13	22	45850	3384	42572079
Multiple organ dysfunction syndrome	20.88	11.13	177	45695	96858	42478605
Postoperative delirium	20.83	11.13	11	45861	589	42574874
Anxiety	20.82	11.13	207	45665	118353	42457110
Intracranial hypotension	20.74	11.13	10	45862	441	42575022
Analgesic therapy	20.59	11.13	30	45842	6494	42568969
Rheumatoid arthritis	20.50	11.13	10	45862	42430	42533033
Iron deficiency	20.39	11.13	40	45832	11021	42564442
Lagophthalmos	19.97	11.13	7	45865	134	42575329
Neuromuscular blockade	19.92	11.13	9	45863	342	42575121
Leukopenia	19.91	11.13	31	45841	74715	42500748
Embolia cutis medicamentosa	19.84	11.13	9	45863	345	42575118
Paraesthesia oral	19.68	11.13	26	45846	5137	42570326
Corneal oedema	19.63	11.13	15	45857	1533	42573930
Endophthalmitis	19.55	11.13	24	45848	4409	42571054
Myoclonus	19.46	11.13	51	45821	17014	42558449
Prostate cancer	19.42	11.13	12	45860	44631	42530832
Seizure like phenomena	19.37	11.13	13	45859	1084	42574379
Sleep disorder therapy	19.34	11.13	30	45842	6864	42568599
Aqueous fibrin	19.19	11.13	6	45866	79	42575384
Loss of consciousness	19.10	11.13	167	45705	92187	42483276
Febrile neutropenia	19.04	11.13	293	45579	185410	42390053
General physical health deterioration	18.92	11.13	91	45781	151155	42424308
Myelosuppression	18.85	11.13	10	45862	40451	42535012
Enterobacter pneumonia	18.68	11.13	10	45862	551	42574912
Reperfusion arrhythmia	18.06	11.13	6	45866	97	42575366
Macular ischaemia	17.94	11.13	7	45865	183	42575280
Blindness	17.79	11.13	51	45821	17927	42557536
Respiratory arrest	17.73	11.13	69	45803	28355	42547108
Spinal meningeal cyst	17.73	11.13	6	45866	103	42575360
Myocardial infarction	17.70	11.13	71	45801	123938	42451525
Thyrotoxic crisis	17.46	11.13	11	45861	823	42574640
Ventricular extrasystoles	17.35	11.13	42	45830	13348	42562115
Administration site pain	17.34	11.13	9	45863	465	42574998
Tryptase increased	17.27	11.13	8	45864	322	42575141
Post procedural complication	16.86	11.13	40	45832	12550	42562913
Suicide attempt	16.69	11.13	15	45857	46085	42529378
Hypoxic-ischaemic encephalopathy	16.54	11.13	24	45848	5178	42570285
Laryngospasm	16.35	11.13	15	45857	1973	42573490
Behaviour disorder	16.14	11.13	28	45844	7026	42568437
Infusion site bruising	16.14	11.13	11	45861	941	42574522
Dermatitis contact	16.13	11.13	22	45850	4481	42570982
Pancreatitis acute	16.07	11.13	8	45864	33556	42541907
Melaena	16.05	11.13	11	45861	38735	42536728
Wrong product administered	15.96	11.13	26	45846	6200	42569263
Body temperature increased	15.74	11.13	53	45819	20305	42555158
Hypophosphataemia	15.73	11.13	54	45818	20891	42554572
Catecholamine crisis	15.71	11.13	5	45867	70	42575393
Myalgia	15.69	11.13	52	45820	96028	42479435
Drug-induced liver injury	15.68	11.13	11	45861	38262	42537201
Swelling	15.66	11.13	107	45765	54778	42520685
Pneumocystis jirovecii pneumonia	15.45	11.13	4	45868	25177	42550286
Hyperaesthesia	15.45	11.13	25	45847	5927	42569536
Anal sphincter atony	15.19	11.13	6	45866	162	42575301
Vitreous disorder	15.13	11.13	6	45866	164	42575299
Cardiotoxicity	15.05	11.13	28	45844	7417	42568046
Cardiac failure congestive	14.91	11.13	45	45827	85557	42489906
Ventricular asystole	14.86	11.13	7	45865	293	42575170
Haematochezia	14.85	11.13	25	45847	58411	42517052
Diabetic ketoacidosis	14.83	11.13	3	45869	22364	42553099
Bacteroides infection	14.76	11.13	16	45856	2571	42572892
Torsade de pointes	14.55	11.13	30	45842	8564	42566899
Completed suicide	14.55	11.13	54	45818	96411	42479052
Appendicitis	14.49	11.13	52	45820	20561	42554902
Pulse absent	14.33	11.13	25	45847	6302	42569161
Vitreous floaters	14.16	11.13	20	45852	4210	42571253
Delayed recovery from anaesthesia	14.11	11.13	11	45861	1158	42574305
Electrocardiogram T wave amplitude increased	13.97	11.13	5	45867	102	42575361
Macroglossia	13.96	11.13	8	45864	504	42574959
Frequent bowel movements	13.93	11.13	3	45869	21404	42554059
Phaeochromocytoma crisis	13.88	11.13	5	45867	104	42575359
Hepatitis	13.86	11.13	6	45866	27294	42548169
Hypoaesthesia oral	13.71	11.13	21	45851	4752	42570711
Abdominal discomfort	13.51	11.13	39	45833	75216	42500247
Product contamination microbial	13.51	11.13	9	45863	741	42574722
Therapy non-responder	13.47	11.13	101	45771	53258	42522205
White blood cell count decreased	13.46	11.13	67	45805	110329	42465134
Blood uric acid increased	13.39	11.13	42	45830	15505	42559958
Procedural hypotension	13.34	11.13	10	45862	993	42574470
Myokymia	13.33	11.13	5	45867	117	42575346
Procedural pain	13.30	11.13	23	45849	5756	42569707
Ophthalmoplegia	13.25	11.13	14	45858	2186	42573277
Postictal state	13.19	11.13	10	45862	1010	42574453
Ventricular arrhythmia	13.18	11.13	24	45848	6255	42569208
Haemoglobin decreased	13.14	11.13	86	45786	132385	42443078
Upper respiratory tract infection	13.11	11.13	84	45788	42089	42533374
Asthma	12.95	11.13	30	45842	62284	42513179
Weight increased	12.90	11.13	66	45806	107917	42467546
Oxygen saturation decreased	12.87	11.13	116	45756	64571	42510892
Encephalomalacia	12.84	11.13	10	45862	1051	42574412
Treatment noncompliance	12.77	11.13	13	45859	37659	42537804
Oesophageal obstruction	12.76	11.13	8	45864	594	42574869
Drug hypersensitivity	12.66	11.13	163	45709	99226	42476237
Malignant neoplasm progression	12.53	11.13	67	45805	108333	42467130
Erythema	12.45	11.13	175	45697	108618	42466845
Brain hypoxia	12.34	11.13	8	45864	629	42574834
Mean arterial pressure increased	12.32	11.13	4	45868	60	42575403
Chills	12.29	11.13	155	45717	93911	42481552
Pancreatic enzymes increased	12.17	11.13	9	45863	876	42574587
Total lung capacity decreased	12.13	11.13	17	45855	3553	42571910
Retinal vasculitis	12.05	11.13	8	45864	655	42574808
Hepatotoxicity	12.05	11.13	6	45866	25161	42550302
Illness	12.04	11.13	56	45816	24874	42550589
Infusion site pruritus	11.96	11.13	10	45862	1163	42574300
Haemorrhoids	11.91	11.13	43	45829	17054	42558409
Lung opacity	11.86	11.13	22	45850	5815	42569648
Kidney congestion	11.86	11.13	7	45865	466	42574997
Pulmonary fibrosis	11.84	11.13	7	45865	26674	42548789
Asthenia	11.81	11.13	222	45650	280571	42294892
Respiratory acidosis	11.80	11.13	23	45849	6308	42569155
Disability	11.60	11.13	22	45850	5911	42569552
Thrombocytopenia	11.59	11.13	140	45732	190139	42385324
Blood pressure systolic increased	11.51	11.13	8	45864	27960	42547503
Post herpetic neuralgia	11.43	11.13	10	45862	1236	42574227
Anaemia	11.35	11.13	223	45649	280055	42295408
Open globe injury	11.30	11.13	4	45868	79	42575384
Myotonic dystrophy	11.24	11.13	5	45867	183	42575280
Therapeutic product effect incomplete	11.17	11.13	39	45833	70900	42504563
Dyspepsia	11.15	11.13	17	45855	41335	42534128

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Local anaesthetic systemic toxicity	1364.53	9.65	402	100178	5135	110483584
Anaphylactic reaction	530.79	9.65	585	99995	113715	110375004
Anaphylactic shock	505.05	9.65	400	100180	51146	110437573
Cardiac arrest	418.77	9.65	688	99892	196065	110292654
Toxic anterior segment syndrome	324.00	9.65	121	100459	3333	110485386
Methaemoglobinaemia	291.91	9.65	150	100430	9018	110479701
Maternal exposure during delivery	291.58	9.65	113	100467	3452	110485267
Hypotension	261.80	9.65	1055	99525	522794	109965925
Anaesthetic complication	231.48	9.65	96	100484	3510	110485209
Synovitis	204.24	9.65	11	100569	274081	110214638
Generalised tonic-clonic seizure	200.41	9.65	248	100332	54432	110434287
Toxicity to various agents	196.29	9.65	911	99669	479644	110009075
Bradycardia	185.53	9.65	426	100154	155091	110333628
Kounis syndrome	171.64	9.65	91	100489	5834	110482885
Hand deformity	168.49	9.65	7	100573	218499	110270220
Inspiratory capacity decreased	159.56	9.65	67	100513	2528	110486191
Systemic lupus erythematosus	157.78	9.65	22	100558	254316	110234403
Fear	153.77	9.65	144	100436	23049	110465670
Helicobacter infection	150.52	9.65	3	100577	181874	110306845
Ventricular tachycardia	144.77	9.65	202	100378	49807	110438912
Pemphigus	144.43	9.65	14	100566	214556	110274163
Ventricular fibrillation	144.40	9.65	183	100397	41130	110447589
Hepatic enzyme increased	143.68	9.65	56	100524	320836	110167883
Pericarditis	143.10	9.65	16	100564	219098	110269621
Joint swelling	142.78	9.65	116	100464	442729	110045990
Anti-cyclic citrullinated peptide antibody positive	139.74	9.65	6	100574	181978	110306741
Duodenal ulcer perforation	135.98	9.65	6	100574	177694	110311025
Glossodynia	133.54	9.65	21	100559	221983	110266736
Renal injury	129.50	9.65	119	100461	18594	110470125
Unresponsive to stimuli	128.73	9.65	218	100362	63572	110425147
Emotional distress	128.11	9.65	180	100400	44667	110444052
Contraindicated product administered	127.61	9.65	34	100546	248233	110240486
Seizure	121.96	9.65	460	100120	220725	110267994
Arthropathy	114.86	9.65	59	100521	287463	110201256
Anhedonia	114.40	9.65	102	100478	15326	110473393
Stress cardiomyopathy	110.32	9.65	101	100479	15705	110473014
General physical health deterioration	107.92	9.65	137	100443	425158	110063561
Anaesthetic complication neurological	107.26	9.65	39	100541	994	110487725
Unevaluable event	104.72	9.65	191	100389	59036	110429683
Folliculitis	102.79	9.65	15	100565	167638	110321081
Pulseless electrical activity	101.52	9.65	99	100481	16658	110472061
Drug ineffective for unapproved indication	99.49	9.65	260	100320	102578	110386141
Mobility decreased	94.40	9.65	49	100531	237373	110251346
Tachycardia	94.03	9.65	432	100148	226213	110262506
Rheumatoid factor positive	92.91	9.65	7	100573	131633	110357086
Wound	92.30	9.65	49	100531	234388	110254331
Type 2 diabetes mellitus	91.58	9.65	24	100556	177208	110311511
Muscle injury	90.13	9.65	11	100569	140796	110347923
Abdominal discomfort	88.82	9.65	138	100442	393720	110094999
Psoriatic arthropathy	88.59	9.65	34	100546	196727	110291992
Rheumatic fever	88.01	9.65	6	100574	122573	110366146
Status epilepticus	84.70	9.65	123	100457	31448	110457271
Procedural hypotension	82.69	9.65	42	100538	2463	110486256
Mental status changes	82.55	9.65	201	100379	75921	110412798
Apnoea	81.54	9.65	80	100500	13559	110475160
Liver injury	80.36	9.65	19	100561	150394	110338325
Insurance issue	80.36	9.65	71	100509	10541	110478178
Rheumatoid arthritis	77.55	9.65	95	100485	299518	110189201
Therapeutic product effect decreased	76.21	9.65	66	100514	244250	110244469
Cardiogenic shock	76.12	9.65	164	100416	57174	110431545
Corneal oedema	76.05	9.65	43	100537	3130	110485589
Facet joint syndrome	74.96	9.65	3	100577	96825	110391894
Neurotoxicity	73.20	9.65	135	100445	42072	110446647
Sinus tachycardia	73.04	9.65	139	100441	44354	110444365
Stress	70.85	9.65	234	100346	105114	110383605
Pulse absent	70.83	9.65	68	100512	11224	110477495
Product adhesion issue	70.07	9.65	40	100540	2966	110485753
C-reactive protein abnormal	70.05	9.65	16	100564	129679	110359040
Infusion related reaction	69.53	9.65	152	100428	381010	110107709
Incorrect route of product administration	69.30	9.65	169	100411	63892	110424827
Bronchospasm	68.64	9.65	109	100471	30130	110458589
Impaired healing	67.84	9.65	48	100532	196669	110292050
Irritable bowel syndrome	66.60	9.65	33	100547	164182	110324537
Drug intolerance	65.53	9.65	173	100407	406339	110082380
Hypoxia	64.55	9.65	261	100319	129254	110359465
Alopecia	64.45	9.65	148	100432	364605	110124114
Lip dry	63.61	9.65	8	100572	100075	110388644
Sleep disorder due to general medical condition, insomnia type	63.49	9.65	10	100570	105633	110383086
Drug ineffective	63.45	9.65	1819	98761	1518721	108969998
Hyperthermia malignant	62.90	9.65	41	100539	3859	110484860
Cauda equina syndrome	62.62	9.65	33	100547	2089	110486630
Bursitis	60.93	9.65	21	100559	129897	110358822
Lagophthalmos	60.46	9.65	22	100558	562	110488157
Endophthalmitis	60.45	9.65	54	100526	8133	110480586
Myelosuppression	58.85	9.65	8	100572	94332	110394387
Hypercholesterolaemia	58.37	9.65	7	100573	90830	110397889
Infusion site pain	57.47	9.65	75	100505	17344	110471375
Obesity	57.32	9.65	16	100564	113335	110375384
Dermatitis contact	57.18	9.65	67	100513	13886	110474833
Inflammation	56.93	9.65	55	100525	193183	110295536
Sulphaemoglobinaemia	56.37	9.65	21	100559	574	110488145
Embolia cutis medicamentosa	56.33	9.65	24	100556	939	110487780
Ill-defined disorder	55.78	9.65	37	100543	156816	110331903
Extradural abscess	55.44	9.65	30	100550	2004	110486715
Haemodynamic instability	55.42	9.65	85	100495	22803	110465916
Peripheral venous disease	55.26	9.65	6	100574	84111	110404608
Respiratory depression	55.05	9.65	102	100478	31899	110456820
Swollen joint count increased	54.87	9.65	6	100574	83655	110405064
Arthralgia	53.88	9.65	452	100128	779180	109709539
Electrocardiogram ST segment elevation	53.41	9.65	53	100527	9107	110479612
Musculoskeletal stiffness	53.18	9.65	109	100471	279713	110209006
Type I hypersensitivity	52.91	9.65	45	100535	6348	110482371
Overdose	52.82	9.65	379	100201	233415	110255304
Infusion site bruising	52.75	9.65	36	100544	3658	110485061
Completed suicide	52.65	9.65	87	100493	242294	110246425
Blister	51.86	9.65	79	100501	227297	110261422
Infusion site swelling	51.85	9.65	54	100526	9823	110478896
Anterior chamber cell	50.87	9.65	24	100556	1197	110487522
Hypopyon	50.04	9.65	25	100555	1415	110487304
Trigemino-cardiac reflex	49.72	9.65	18	100562	453	110488266
Illness	49.54	9.65	176	100404	81995	110406724
Extradural haematoma	48.50	9.65	33	100547	3336	110485383
Infusion site erythema	48.30	9.65	57	100523	11902	110476817
Osteoarthritis	48.19	9.65	57	100523	182566	110306153
Fibromyalgia	47.66	9.65	51	100529	170858	110317861
Electrocardiogram QRS complex prolonged	47.60	9.65	59	100521	12962	110475757
Gait inability	47.38	9.65	33	100547	136343	110352376
Anal inflammation	47.15	9.65	29	100551	2467	110486252
Premature delivery	46.99	9.65	93	100487	30539	110458180
Systemic toxicity	46.47	9.65	16	100564	346	110488373
Infusion site extravasation	46.25	9.65	55	100525	11579	110477140
Liver disorder	46.10	9.65	37	100543	142206	110346513
C-reactive protein increased	45.69	9.65	80	100500	217839	110270880
Multiple organ dysfunction syndrome	44.71	9.65	263	100317	151447	110337272
Loss of consciousness	44.20	9.65	318	100262	195988	110292731
Abdominal pain upper	43.97	9.65	166	100414	348945	110139774
Spinal cord infarction	43.97	9.65	21	100559	1077	110487642
Circulatory collapse	43.94	9.65	111	100469	42882	110445837
Retinal artery occlusion	43.80	9.65	34	100546	4215	110484504
Infusion site pruritus	42.98	9.65	36	100544	4972	110483747
Lower respiratory tract infection	42.63	9.65	99	100481	243007	110245712
Proctalgia	42.18	9.65	56	100524	13166	110475553
Paraplegia	42.07	9.65	39	100541	6161	110482558
Aqueous fibrin	41.82	9.65	13	100567	201	110488518
Urinary tract infection	41.65	9.65	467	100113	325815	110162904
Interstitial lung disease	40.64	9.65	40	100540	139294	110349425
Vitritis	40.62	9.65	27	100553	2626	110486093
Anxiety	40.53	9.65	486	100094	344592	110144127
Ophthalmoplegia	40.11	9.65	30	100550	3520	110485199
Retinal vasculitis	39.20	9.65	24	100556	2025	110486694
Pulmonary fibrosis	39.16	9.65	22	100558	102020	110386699
Hepatitis	38.20	9.65	17	100563	90037	110398682
SARS-CoV-2 test negative	38.11	9.65	24	100556	2129	110486590
Joint range of motion decreased	37.86	9.65	33	100547	121799	110366920
Respiratory tract infection	37.82	9.65	147	100433	71470	110417249
Accidental overdose	37.43	9.65	118	100462	51716	110437003
Post procedural complication	37.40	9.65	78	100502	26580	110462139
Haemorrhoids	37.40	9.65	93	100487	35579	110453140
Mydriasis	37.33	9.65	70	100510	22087	110466632
Staphylococcal infection	37.29	9.65	144	100436	69800	110418919
Peripheral nerve injury	37.17	9.65	19	100561	1129	110487590
Colitis ulcerative	37.15	9.65	12	100568	77351	110411368
Fear of eating	37.11	9.65	15	100565	513	110488206
Adulterated product	37.06	9.65	19	100561	1136	110487583
Vasoplegia syndrome	36.49	9.65	34	100546	5405	110483314
Nail disorder	35.93	9.65	5	100575	57930	110430789
COVID-19	35.58	9.65	360	100220	244700	110244019
Respiratory tract infection bacterial	35.58	9.65	24	100556	2392	110486327
Drug-induced liver injury	35.56	9.65	34	100546	120033	110368686
Psoriasis	35.55	9.65	45	100535	139948	110348771
Hypoaesthesia oral	35.48	9.65	59	100521	16943	110471776
Febrile neutropenia	35.40	9.65	442	100138	316325	110172394
Seasonal allergy	35.36	9.65	64	100516	19658	110469061
Chemical burn	35.21	9.65	16	100564	732	110487987
Meningitis chemical	34.84	9.65	13	100567	357	110488362
Deep vein thrombosis postoperative	34.76	9.65	6	100574	59285	110429434
Brain oedema	34.65	9.65	83	100497	31015	110457704
Pulmonary oedema	34.65	9.65	182	100398	100477	110388242
Appendicolith	34.60	9.65	53	100527	14202	110474517
Grip strength decreased	34.22	9.65	15	100565	80159	110408560
Vascular malformation	33.91	9.65	16	100564	798	110487921
Infusion site haemorrhage	33.30	9.65	30	100550	4568	110484151
Tracheitis	32.52	9.65	20	100560	1701	110487018
Spinal epidural haematoma	32.48	9.65	20	100560	1705	110487014
Nystagmus	32.36	9.65	46	100534	11531	110477188
Paranasal cyst	32.32	9.65	16	100564	888	110487831
Spinal epidural haemorrhage	32.28	9.65	12	100568	326	110488393
Postoperative delirium	32.13	9.65	16	100564	899	110487820
Adverse event	32.00	9.65	31	100549	108778	110379941
Blood phosphorus increased	31.84	9.65	55	100525	16285	110472434
Cardiotoxicity	31.83	9.65	56	100524	16825	110471894
Lung disorder	31.82	9.65	73	100507	179974	110308745
Tryptase increased	31.68	9.65	16	100564	927	110487792
Analgesic therapy	31.57	9.65	36	100544	7248	110481471
Drug therapy	31.54	9.65	36	100544	7255	110481464
Ventricular extrasystoles	31.48	9.65	66	100514	22575	110466144
Wrong product administered	31.31	9.65	44	100536	10916	110477803
Neuralgia	31.09	9.65	106	100474	48372	110440347
Sinusitis	31.04	9.65	409	100171	296279	110192440
Frequent bowel movements	31.03	9.65	13	100567	71377	110417342
Upper respiratory tract infection	30.87	9.65	215	100365	131113	110357606
Sleep disorder therapy	30.82	9.65	36	100544	7435	110481284
Anal sphincter atony	30.67	9.65	13	100567	502	110488217
Condition aggravated	30.64	9.65	477	100103	734359	109754360
Gastrointestinal disorder	30.48	9.65	115	100465	241837	110246882
Hyperphosphataemia	30.44	9.65	54	100526	16327	110472392
Delayed recovery from anaesthesia	30.24	9.65	21	100559	2194	110486525
Oculocardiac reflex	30.04	9.65	9	100571	122	110488597
Prescribed underdose	29.76	9.65	11	100569	65163	110423556
Stridor	29.75	9.65	34	100546	6861	110481858
Paralysis	29.74	9.65	52	100528	15548	110473171
Corneal epithelium defect	29.26	9.65	15	100565	897	110487822
Blepharospasm	29.15	9.65	7	100573	54844	110433875
Arthritis	28.77	9.65	69	100511	167517	110321202
Incorrect drug administration rate	28.71	9.65	30	100550	5478	110483241
Purtscher retinopathy	28.67	9.65	10	100570	225	110488494
Coeliac disease	28.57	9.65	3	100577	43184	110445535
Asthenia	28.46	9.65	448	100132	688551	109800168
Accident	28.41	9.65	42	100538	10910	110477809
Lower limb fracture	27.84	9.65	17	100563	75331	110413388
Diabetes insipidus	27.68	9.65	32	100548	6538	110482181
Neuromuscular block prolonged	27.48	9.65	16	100564	1231	110487488
Infusion site mass	27.46	9.65	18	100562	1710	110487009
Musculoskeletal pain	27.15	9.65	81	100499	182942	110305777
Underdose	26.95	9.65	12	100568	63542	110425177
Negative pressure pulmonary oedema	26.87	9.65	13	100567	686	110488033
Weight increased	26.84	9.65	248	100332	419396	110069323
Wheezing	26.81	9.65	130	100450	255100	110233619
Myasthenia gravis	26.81	9.65	60	100520	21451	110467268
Blood pressure decreased	26.80	9.65	188	100392	114903	110373816
Upper airway obstruction	26.77	9.65	18	100562	1784	110486935
Product dose omission issue	26.68	9.65	426	100154	321356	110167363
Epidural haemorrhage	26.52	9.65	11	100569	402	110488317
Therapy partial responder	26.42	9.65	84	100496	36977	110451742
Respiratory arrest	26.31	9.65	114	100466	58185	110430534
Multiple allergies	26.19	9.65	43	100537	12220	110476499
Hypersensitivity	26.16	9.65	238	100342	403760	110084959
Neuromuscular blockade	26.10	9.65	13	100567	731	110487988
Onychomadesis	25.95	9.65	5	100575	45658	110443061
Otitis media	25.93	9.65	33	100547	7443	110481276
Procedural complication	25.90	9.65	35	100545	8370	110480349
Therapeutic product effect incomplete	25.90	9.65	110	100470	223695	110265024
Platelet aggregation inhibition	25.87	9.65	9	100571	201	110488518
Visual acuity reduced	25.81	9.65	76	100504	32097	110456622
Swelling	25.80	9.65	200	100380	350841	110137878
Respiratory distress	25.42	9.65	127	100453	68747	110419972
Punctate keratitis	25.36	9.65	15	100565	1189	110487530
Diarrhoea	25.30	9.65	817	99763	1138688	109350031
Infusion site urticaria	25.22	9.65	15	100565	1201	110487518
Blood cholesterol increased	25.15	9.65	85	100495	184700	110304019
Medical device site cellulitis	25.03	9.65	9	100571	222	110488497
Bursitis infective	24.99	9.65	16	100564	1460	110487259
Back pain	24.96	9.65	475	100105	370521	110118198
Trigeminal palsy	24.87	9.65	7	100573	75	110488644
Sepsis	24.79	9.65	427	100153	326919	110161800
Night sweats	24.76	9.65	53	100527	133930	110354789
Red blood cell sedimentation rate increased	24.58	9.65	21	100559	78281	110410438
Cyanosis	24.58	9.65	71	100509	29670	110459049
Prescribed overdose	24.56	9.65	26	100554	87555	110401164
Pneumocephalus	24.54	9.65	11	100569	487	110488232
Wound infection	24.50	9.65	31	100549	96434	110392285
Foetal heart rate abnormal	24.29	9.65	12	100568	663	110488056
Lupus-like syndrome	24.20	9.65	4	100576	40788	110447931
Body tinea	24.18	9.65	18	100562	2097	110486622
Spinal cord compression	24.11	9.65	32	100548	7520	110481199
Loss of personal independence in daily activities	24.02	9.65	64	100516	149956	110338763
Product contamination microbial	24.01	9.65	14	100566	1080	110487639
Brain stem syndrome	23.88	9.65	15	100565	1324	110487395
Parophthalmia	23.77	9.65	11	100569	525	110488194
Epidural analgesia	23.59	9.65	8	100572	165	110488554
Inadequate analgesia	23.55	9.65	26	100554	5051	110483668
Cytomegalovirus infection	23.53	9.65	10	100570	54434	110434285
Suicide attempt	23.49	9.65	36	100544	103358	110385361
Hypophosphataemia	23.47	9.65	75	100505	33107	110455612
Stomatitis	23.27	9.65	147	100433	270095	110218624
Procedure aborted	23.23	9.65	8	100572	173	110488546
Hyperaesthesia	22.93	9.65	45	100535	14682	110474037
Peripheral swelling	22.82	9.65	246	100334	403788	110084931
Myoclonus	22.81	9.65	74	100506	32924	110455795
Drug reaction with eosinophilia and systemic symptoms	22.32	9.65	25	100555	82070	110406649
Eyelid ptosis	22.32	9.65	42	100538	13285	110475434
Chills	22.17	9.65	268	100312	190312	110298407
Medical device site abscess	22.07	9.65	8	100572	202	110488517
Blindness	22.01	9.65	78	100502	36281	110452438
Spinal anaesthesia	21.96	9.65	7	100573	118	110488601
Airway peak pressure increased	21.83	9.65	11	100569	634	110488085
Torsade de pointes	21.70	9.65	57	100523	22543	110466176
Mean arterial pressure decreased	21.54	9.65	10	100570	481	110488238
Hip arthroplasty	21.46	9.65	12	100568	55801	110432918
Hepatic cirrhosis	21.40	9.65	18	100562	67608	110421111
Shock	21.35	9.65	101	100479	53487	110435232
Respiratory failure	21.33	9.65	294	100286	215038	110273681
Nerve root injury	21.17	9.65	6	100574	66	110488653
Macular ischaemia	21.00	9.65	8	100572	233	110488486
Knee arthroplasty	20.91	9.65	17	100563	64931	110423788
Mastoiditis	20.84	9.65	18	100562	2593	110486126
Infusion site discharge	20.80	9.65	16	100564	1957	110486762
Epilepsy	20.80	9.65	37	100543	100172	110388547
Bacterial infection	20.75	9.65	90	100490	45946	110442773
Miosis	20.66	9.65	55	100525	21928	110466791
Drug level increased	20.53	9.65	92	100488	47627	110441092
Decreased appetite	20.44	9.65	307	100273	475539	110013180
Tubulointerstitial nephritis	20.40	9.65	12	100568	54272	110434447
Haematochezia	20.28	9.65	47	100533	115477	110373242
Iron deficiency	20.25	9.65	49	100531	18427	110470292
Dyspepsia	20.21	9.65	97	100483	190868	110297851
Atonic urinary bladder	20.01	9.65	7	100573	159	110488560
Carbon dioxide decreased	19.89	9.65	23	100557	4701	110484018
Appendicitis	19.82	9.65	64	100516	28400	110460319
Cardio-respiratory arrest	19.70	9.65	176	100404	115660	110373059
Bundle branch block left	19.61	9.65	39	100541	12849	110475870
Product use issue	19.57	9.65	185	100395	311510	110177209
Behaviour disorder	19.49	9.65	33	100547	9614	110479105
Tenderness	19.44	9.65	65	100515	29372	110459347
Tachypnoea	19.30	9.65	79	100501	39316	110449403
Leukopenia	19.20	9.65	70	100510	148721	110339998
Pancreatitis acute	19.12	9.65	16	100564	60258	110428461
Product preparation error	19.12	9.65	35	100545	10844	110477875
Intracranial hypotension	19.05	9.65	10	100570	628	110488091
Diplopia	18.96	9.65	82	100498	41812	110446907
Gastroenteritis viral	18.91	9.65	67	100513	31159	110457560
Respiratory tract infection viral	18.91	9.65	25	100555	5853	110482866
Restlessness	18.86	9.65	101	100479	56158	110432561
Skin infection	18.85	9.65	54	100526	22455	110466264
Tremor	18.78	9.65	273	100307	201959	110286760
Hepatotoxicity	18.71	9.65	18	100562	63382	110425337
Acute kidney injury	18.60	9.65	438	100142	634992	109853727
Sinus bradycardia	18.50	9.65	64	100516	29419	110459300
Vaginal abscess	18.44	9.65	9	100571	484	110488235
Pneumocystis jirovecii pneumonia	18.23	9.65	8	100572	42727	110445992
Vocal cord dysfunction	17.85	9.65	11	100569	939	110487780
Agitation	17.82	9.65	169	100411	112882	110375837
Seizure like phenomena	17.82	9.65	16	100564	2425	110486294
Agranulocytosis	17.69	9.65	18	100562	61742	110426977
Sleep disorder	17.64	9.65	107	100473	198537	110290182
Oxygen saturation decreased	17.49	9.65	219	100361	156763	110331956
Anaphylactoid shock	17.47	9.65	11	100569	975	110487744
Nail bed tenderness	17.40	9.65	8	100572	376	110488343
Renal failure	17.31	9.65	296	100284	226278	110262441
Anal skin tags	17.28	9.65	9	100571	556	110488163
Spinal meningeal cyst	17.24	9.65	6	100574	134	110488585
Bacteroides infection	17.22	9.65	17	100563	2902	110485817
Anterior chamber fibrin	17.22	9.65	7	100573	243	110488476
Quadriplegia	17.22	9.65	20	100560	4107	110484612
Economic problem	17.20	9.65	20	100560	4111	110484608
Cholestasis	17.16	9.65	20	100560	64498	110424221
Thrombocytopenia	17.15	9.65	219	100361	348666	110140053
Disease progression	17.01	9.65	141	100439	243893	110244826
Phrenic nerve paralysis	16.96	9.65	9	100571	578	110488141
Laryngospasm	16.82	9.65	21	100559	4647	110484072
Enterobacter pneumonia	16.70	9.65	9	100571	596	110488123
Heparin-induced thrombocytopenia	16.70	9.65	34	100546	11390	110477329
Bronchitis	16.62	9.65	217	100363	156815	110331904
Respiratory acidosis	16.60	9.65	38	100542	13788	110474931
Sensory loss	16.56	9.65	50	100530	21407	110467312
Foot deformity	16.48	9.65	12	100568	48468	110440251
Spinal cord injury	16.47	9.65	13	100567	1652	110487067
Vitamin D increased	16.34	9.65	10	100570	843	110487876
Injection site joint infection	16.29	9.65	5	100575	74	110488645
Hypoxic-ischaemic encephalopathy	16.23	9.65	29	100551	8818	110479901
Rash	16.23	9.65	597	99983	820367	109668352
Infection susceptibility increased	16.19	9.65	20	100560	4378	110484341
Hypercapnia	16.06	9.65	33	100547	11126	110477593
Pupillary reflex impaired	15.99	9.65	19	100561	3996	110484723
Intentional self-injury	15.97	9.65	7	100573	37422	110451297
Ventricular arrhythmia	15.92	9.65	31	100549	10056	110478663
Anaesthetic complication pulmonary	15.84	9.65	6	100574	172	110488547
Aortic stenosis	15.80	9.65	36	100544	13023	110475696
Spinal cord oedema	15.74	9.65	8	100572	470	110488249
Reperfusion arrhythmia	15.68	9.65	7	100573	307	110488412
Airway complication of anaesthesia	15.67	9.65	9	100571	675	110488044
Taste disorder	15.60	9.65	22	100558	65365	110423354
Streptococcal infection	15.44	9.65	32	100548	10858	110477861
Depressed level of consciousness	15.36	9.65	163	100417	112115	110376604
Insomnia	15.35	9.65	233	100347	360357	110128362
Infusion site discomfort	15.34	9.65	13	100567	1824	110486895
Total lung capacity decreased	15.26	9.65	25	100555	7089	110481630
Malaise	15.26	9.65	480	100100	671339	109817380
Vision blurred	15.24	9.65	182	100398	128840	110359879
Onychomycosis	15.23	9.65	8	100572	38523	110450196
Intentional product use issue	15.20	9.65	148	100432	247758	110240961
Implant site bruising	15.17	9.65	7	100573	332	110488387
Confusional state	15.15	9.65	318	100262	468362	110020357
Hepatic function abnormal	15.14	9.65	37	100543	89258	110399461
Orthostatic hypotension	15.11	9.65	23	100557	66226	110422493
Anal ulcer	15.11	9.65	13	100567	1863	110486856
Asthma	15.10	9.65	150	100430	250141	110238578
Catecholamine crisis	15.08	9.65	5	100575	96	110488623
Nasopharyngitis	15.07	9.65	260	100320	394101	110094618
Normal newborn	15.04	9.65	49	100531	21847	110466872
Cholestasis of pregnancy	14.99	9.65	11	100569	1254	110487465
Kidney congestion	14.97	9.65	8	100572	521	110488198
Viral infection	14.93	9.65	91	100489	53048	110435671
Ventricular tachyarrhythmia	14.91	9.65	8	100572	525	110488194
Ear infection	14.91	9.65	103	100477	62629	110426090
Ventricular hypokinesia	14.79	9.65	32	100548	11182	110477537
Product distribution issue	14.79	9.65	19	100561	4327	110484392
Familial periodic paralysis	14.78	9.65	7	100573	352	110488367
Left ventricle outflow tract obstruction	14.77	9.65	8	100572	535	110488184
Atrioventricular block complete	14.76	9.65	46	100534	20036	110468683
Application site alopecia	14.74	9.65	4	100576	37	110488682
Chorioretinopathy	14.73	9.65	14	100566	2281	110486438
Eyelid contusion	14.66	9.65	5	100575	105	110488614
Blood uric acid increased	14.63	9.65	48	100532	21481	110467238
Vascular stenosis	14.60	9.65	9	100571	769	110487950
Serotonin syndrome	14.58	9.65	98	100482	59055	110429664
Paraesthesia oral	14.55	9.65	65	100515	33606	110455113
Eclampsia	14.55	9.65	7	100573	365	110488354
Back injury	14.53	9.65	13	100567	47386	110441333
Retrograde amnesia	14.50	9.65	9	100571	778	110487941
Infusion site rash	14.49	9.65	14	100566	2329	110486390
Monoplegia	14.46	9.65	20	100560	4889	110483830
Erythema	14.41	9.65	357	100223	291090	110197629
Lethargy	14.31	9.65	139	100441	93437	110395282
Repetitive strain injury	14.30	9.65	6	100574	226	110488493
Apnoeic attack	14.24	9.65	9	100571	803	110487916
Nail bed inflammation	14.22	9.65	13	100567	2017	110486702
Vitreous disorder	14.22	9.65	7	100573	384	110488335
Infusion site streaking	14.15	9.65	8	100572	582	110488137
Application site pain	14.13	9.65	21	100559	5478	110483241
Administration site pain	14.05	9.65	9	100571	822	110487897
C-reactive protein	14.05	9.65	5	100575	30326	110458393
Heliotrope rash	14.01	9.65	6	100574	238	110488481
Spinal cord ischaemia	14.01	9.65	6	100574	238	110488481
Lung opacity	13.96	9.65	32	100548	11620	110477099
Kidney infection	13.89	9.65	53	100527	25546	110463173
Autoimmune disorder	13.75	9.65	24	100556	65459	110423260
Injury	13.69	9.65	232	100348	177033	110311686
Axillary nerve injury	13.65	9.65	4	100576	50	110488669
Exostosis	13.62	9.65	13	100567	45943	110442776
Ventricular asystole	13.60	9.65	7	100573	422	110488297
Air embolism	13.55	9.65	8	100572	632	110488087
Diabetic ketoacidosis	13.55	9.65	11	100569	42047	110446672
Irregular breathing	13.54	9.65	8	100572	633	110488086
Body dysmorphic disorder	13.51	9.65	7	100573	428	110488291
Harlequin syndrome	13.40	9.65	6	100574	265	110488454
Encephalomalacia	13.31	9.65	11	100569	1491	110487228
Treatment failure	13.26	9.65	175	100405	277059	110211660
Hepatocellular injury	13.15	9.65	16	100564	50626	110438093
Premature baby	13.14	9.65	19	100561	4836	110483883
Glossoptosis	13.11	9.65	6	100574	279	110488440
Nasal mucosal disorder	13.08	9.65	12	100568	1871	110486848
Atelectasis	13.06	9.65	67	100513	36645	110452074
Product administered at inappropriate site	13.02	9.65	20	100560	5373	110483346
Allergy to immunoglobulin therapy	13.02	9.65	5	100575	149	110488570
Tinnitus	13.00	9.65	97	100483	60443	110428276
Conjunctival oedema	12.97	9.65	11	100569	1545	110487174
Accelerated idioventricular rhythm	12.97	9.65	6	100574	286	110488433
Exophthalmos	12.97	9.65	13	100567	2260	110486459
Liver function test abnormal	12.96	9.65	27	100553	68923	110419796
Myokymia	12.95	9.65	5	100575	151	110488568
Oesophageal obstruction	12.93	9.65	10	100570	1233	110487486
Infective pulmonary exacerbation of cystic fibrosis	12.92	9.65	36	100544	14735	110473984
Procedural haemorrhage	12.92	9.65	20	100560	5407	110483312
Glucose tolerance impaired	12.89	9.65	28	100552	9809	110478910
Oxidative stress	12.86	9.65	4	100576	62	110488657
Spinal stroke	12.74	9.65	4	100576	64	110488655
Thrombosis	12.71	9.65	153	100427	108509	110380210
Brain herniation	12.51	9.65	26	100554	8837	110479882
Femoral nerve injury	12.46	9.65	4	100576	69	110488650
Cellulitis	12.45	9.65	172	100408	125844	110362875
Bone marrow failure	12.33	9.65	21	100559	57827	110430892
Abortion spontaneous	12.30	9.65	8	100572	34274	110454445
Calcinosis	12.20	9.65	14	100566	2838	110485881
Arthritis bacterial	12.19	9.65	29	100551	10791	110477928
Postictal state	12.18	9.65	13	100567	2433	110486286
Quadriparesis	12.13	9.65	18	100562	4689	110484030
Incontinence	12.13	9.65	38	100542	16597	110472122
Acute respiratory failure	12.11	9.65	113	100467	75147	110413572
Angioedema	12.10	9.65	140	100440	98360	110390359
Cystic fibrosis	12.06	9.65	18	100562	4713	110484006
Dystonia	12.06	9.65	51	100529	25754	110462965
Hypoaesthesia	12.05	9.65	207	100373	314016	110174703
Obstruction	12.05	9.65	20	100560	5732	110482987
Allodynia	12.05	9.65	12	100568	2071	110486648
Cytokine release syndrome	12.04	9.65	107	100473	70199	110418520
Opisthotonus	12.04	9.65	8	100572	778	110487941
Orbital infection	12.02	9.65	5	100575	184	110488535
Nerve block	12.01	9.65	8	100572	781	110487938
Allergy to arthropod sting	12.00	9.65	6	100574	340	110488379
Transferrin decreased	11.99	9.65	7	100573	541	110488178
Vitreous floaters	11.97	9.65	26	100554	9108	110479611
Infection	11.92	9.65	245	100335	361955	110126764
Blood pressure fluctuation	11.91	9.65	32	100548	74792	110413927
Memory impairment	11.89	9.65	118	100462	196826	110291893
Activated partial thromboplastin time prolonged	11.88	9.65	46	100534	22322	110466397
Myotonic dystrophy	11.78	9.65	5	100575	194	110488525
Hyperlipidaemia	11.77	9.65	64	100516	35784	110452935
Iron binding capacity total decreased	11.77	9.65	7	100573	560	110488159
Hypoventilation	11.75	9.65	24	100556	8057	110480662
Meningitis	11.73	9.65	30	100550	11672	110477047
Anticoagulant therapy	11.72	9.65	19	100561	5342	110483377
Encephalopathy	11.71	9.65	119	100461	80936	110407783
Retinal detachment	11.70	9.65	29	100551	11071	110477648
Acute pulmonary oedema	11.64	9.65	38	100542	16958	110471761
Sciatica	11.57	9.65	44	100536	92355	110396364
Arthritis fungal	11.49	9.65	5	100575	206	110488513
Intentional product misuse to child	11.47	9.65	5	100575	207	110488512
Antacid therapy	11.40	9.65	19	100561	5465	110483254
Procedural anxiety	11.38	9.65	8	100572	853	110487866
Laboratory test abnormal	11.36	9.65	14	100566	44065	110444654
End-tidal CO2 decreased	11.31	9.65	4	100576	94	110488625
Pancytopenia	11.28	9.65	129	100451	209484	110279235
Disease recurrence	11.26	9.65	24	100556	60760	110427959
Melaena	11.26	9.65	29	100551	68728	110419991
Victim of chemical submission	11.23	9.65	8	100572	871	110487848
Intraocular pressure fluctuation	11.23	9.65	4	100576	96	110488623
Weight decreased	11.21	9.65	332	100248	467725	110020994
Diplegia	11.14	9.65	12	100568	2269	110486450
Deafness bilateral	11.11	9.65	13	100567	2691	110486028
Uveitis	11.09	9.65	3	100577	21707	110467012
Intercepted medication error	10.98	9.65	9	100571	1207	110487512
Poor quality product administered	10.91	9.65	17	100563	4624	110484095
Anaesthetic complication cardiac	10.89	9.65	4	100576	105	110488614
Dermatitis diaper	10.83	9.65	6	100574	420	110488299
Deafness permanent	10.81	9.65	8	100572	923	110487796
Brugada syndrome	10.79	9.65	10	100570	1578	110487141
Amaurosis	10.79	9.65	10	100570	1579	110487140
Pruritus	10.79	9.65	426	100154	581134	109907585
Exposure during pregnancy	10.78	9.65	213	100367	167211	110321508
Lymphatic disorder	10.76	9.65	6	100574	425	110488294
Corneal opacity	10.75	9.65	9	100571	1242	110487477
Vasospasm	10.75	9.65	10	100570	1586	110487133
Prostate cancer	10.75	9.65	11	100569	37630	110451089
Lung neoplasm malignant	10.72	9.65	9	100571	33833	110454886
Ingrowing nail	10.69	9.65	14	100566	3248	110485471
Infusion site nodule	10.68	9.65	6	100574	431	110488288
Induration	10.68	9.65	12	100568	2377	110486342
Slow response to stimuli	10.67	9.65	11	100569	1977	110486742
Accidental exposure to product	10.67	9.65	80	100500	49928	110438791
Drug resistance	10.66	9.65	22	100558	56352	110432367
Sympathectomy	10.59	9.65	3	100577	33	110488686
Coccygectomy	10.59	9.65	3	100577	33	110488686
Varicose vein	10.56	9.65	21	100559	6919	110481800
Dysarthria	10.53	9.65	120	100460	84001	110404718
Injection site joint swelling	10.51	9.65	3	100577	34	110488685
Muscle strain	10.50	9.65	28	100552	11174	110477545
Mean arterial pressure increased	10.48	9.65	4	100576	117	110488602
Drug tolerance decreased	10.48	9.65	6	100574	27534	110461185
Electrocardiogram QT prolonged	10.47	9.65	148	100432	108812	110379907
Jaundice	10.47	9.65	24	100556	59212	110429507
Sinusitis bacterial	10.46	9.65	12	100568	2432	110486287
Foreign body sensation in eyes	10.45	9.65	14	100566	3320	110485399
Thyrotoxic crisis	10.43	9.65	11	100569	2029	110486690
Vascular resistance systemic decreased	10.39	9.65	5	100575	261	110488458
Fear of death	10.38	9.65	10	100570	1657	110487062
Pupil fixed	10.36	9.65	15	100565	3823	110484896
Blindness transient	10.26	9.65	19	100561	5937	110482782
Progressive multifocal leukoencephalopathy	10.14	9.65	5	100575	24951	110463768
Incision site rash	10.13	9.65	3	100577	39	110488680
Haemorrhagic vasculitis	10.12	9.65	4	100576	129	110488590
Blood pressure systolic increased	10.09	9.65	40	100540	82951	110405768
Syringomyelia	10.04	9.65	5	100575	281	110488438
Brain injury	10.02	9.65	31	100549	13445	110475274
Poikiloderma	10.02	9.65	6	100574	486	110488233
Pneumonia mycoplasmal	10.01	9.65	10	100570	1731	110486988
Deafness neurosensory	10	9.65	25	100555	9594	110479125
Hypertonia	9.98	9.65	23	100557	8383	110480336
Injection site atrophy	9.95	9.65	6	100574	493	110488226
Accidental death	9.94	9.65	17	100563	4992	110483727
Gamma-glutamyltransferase increased	9.93	9.65	26	100554	61283	110427436
Device infusion issue	9.87	9.65	13	100567	3032	110485687
Tracheal deviation	9.85	9.65	5	100575	293	110488426
Corneal abrasion	9.83	9.65	9	100571	1400	110487319
Moraxella infection	9.82	9.65	7	100573	763	110487956
Application site erythema	9.80	9.65	18	100562	5592	110483127
Discomfort	9.74	9.65	137	100443	214570	110274149
Product prescribing error	9.74	9.65	20	100560	51311	110437408
Cancer pain	9.72	9.65	20	100560	6752	110481967
Physical disability	9.71	9.65	17	100563	5089	110483630
Neuroleptic malignant syndrome	9.67	9.65	10	100570	34049	110454670

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D06AX05	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use
ATC	J01XX10	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Other antibacterials
ATC	R02AB04	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antibiotics
ATC	S01AA32	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
FDA PE	N0000008479	Decreased Cell Wall Synthesis & Repair
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D000900	Anti-Bacterial Agents
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:176497	geroprotector
CHEBI has role	CHEBI:67079	anti-inflammatory agent

Related Drugs by ATC class:

D06AX Other antibiotics for topical use 12 drugs

amikacin chloramphenicol fusidic acid gentamicin mupirocin neomycin ozenoxacin retapamulin rifamycin rifaximin tyrothricin virginiamycin

J01XX Other antibacterials 12 drugs

clofoctol daptomycin fosfomycin gepotidacin lefamulin linezolid mandelic acid methenamine nitroxoline spectinomycin tedizolid phosphate xibornol

R02AB Antibiotics 4 drugs

fusafungine gramicidin neomycin tyrothricin

S01AA Antibiotics 27 drugs

amikacin ampicillin azidamfenicol azithromycin benzylpenicillin cefmenoxime cefuroxime chloramphenicol chlortetracycline dibekacin dihydrostreptomycin erythromycin show all 27 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Keratitis	indication	5888003	DOID:4677
Blepharoconjunctivitis	indication	68659002	DOID:2456
Corneal abrasion	indication	85848002
Infective blepharitis	indication	312219000
Bacterial keratitis	indication	314557000
Superficial Ocular Infection	indication
Minor Bacterial Skin Infections	indication
Dacryocystitis	off-label use	85777005	DOID:9938
Corneal ulcer	off-label use	91514001	DOID:8463
Bacterial conjunctivitis	off-label use	128350005	DOID:9700
Meibomianitis	off-label use	309779001
Ocular hypertension	contraindication	4210003	DOID:9282
Herpes simplex keratitis	contraindication	9389005
Bacterial septicemia	contraindication	10001005	DOID:0040085
Shock	contraindication	27942005
Herpes simplex dendritic keratitis	contraindication	29943008
Fungal infection of eye	contraindication	31194008
Severe myopia	contraindication	34187009
Tuberculosis of eye	contraindication	49107007
Diabetes mellitus	contraindication	73211009	DOID:9351
Third degree burn injury	contraindication	80247002
Decreased respiratory function	contraindication	80954004
Oliguria	contraindication	83128009
Open-angle glaucoma	contraindication	84494001	DOID:1067
Krukenberg spindle	contraindication	85430004
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Open wound	contraindication	125643001
Eye infection	contraindication	128351009
Seizure disorder	contraindication	128613002
Bacterial infection of eye	contraindication	128984004
Heart block	contraindication	233916004
Disease of liver	contraindication	235856003	DOID:409
Telangiectasia disorder	contraindication	247479008
Injury of eye region	contraindication	282752000
Pregnancy, function	contraindication	289908002
Viral eye infection	contraindication	312132001
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Vaccinia keratitis	contraindication	397552005
Atrophoderma	contraindication	399979006
Peripheral vascular disease	contraindication	400047006
Denuded skin	contraindication	418242004

🐶 Veterinary Drug Use

Species	Use	Relation
Cattle	Necrotic enteritis caused or complicated by Clostridium species	Indication
Cattle	To increase rate of weight gain	Indication
Cattle	To improve feed efficiency	Indication
Cattle	To increases egg production	Indication
Chickens	Necrotic enteritis caused or complicated by Clostridium species	Indication
Chickens	To increase rate of weight gain	Indication
Chickens	Improves feed efficiency during the first seven months of production	Indication
Chickens	Increases egg productionduring the first seven months of production	Indication
Pheasants	To increase rate of weight gain	Indication
Pheasants	To improve feed efficiency	Indication
Quail	To increase rate of weight gain	Indication
Quail	To improve feed efficiency	Indication
Swine	Enteritis caused by Clostridium perfringens	Indication
Swine	Swine dysentery associated with Treponema hyodysenteriae	Indication
Swine	To increase rate of weight gain	Indication
Swine	To improve feed efficiency	Indication
Turkeys	Enteritis	Indication
Turkeys	To increase rate of weight gain	Indication
Turkeys	To improve feed efficiency	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Amprol HI-E Plus	Huvepharma EOOD	3
Albac / Deccox, Broiler Finisher Medicated	Zoetis Inc.	2
BMD 30 Granular A, BMD 50 Granular A, BMD 30, BMD 50, BMD 60	Zoetis Inc.	1
Baciferm - 10, Baciferm - 25, Baciferm - 40, Baciferm - 50	Zoetis Inc.	1
Coban plus Baciferm	Elanco US Inc.	2
Coban plus BMD	Elanco US Inc.	2
Coyden 25 with Bacitracin Zinc	Huvepharma EOOD	2
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment	Dechra, Ltd.	4
Bac-Neo-Poly Ophthalmic Ointment, Vetropolycin Ophthalmic Ointment	Dechra, Ltd.	3
Entromycin Powder	Zoetis Inc.	2
Mycitracin Sterile Ophthalmic Ointment	Zoetis Inc.	3
Soluble Fortracin Concentrate	Zoetis Inc.	1
Baciferm Soluble 50	Zoetis Inc.	1
BMD Soluble	Zoetis Inc.	1
Cortisporin Veterinary Ophthalmic Ointment	Intervet Inc.	4
Neosporin Ophthalmic Ointment	Intervet Inc.	3
Robenz Plus Zn Bacitracin	Zoetis Inc.	2
Bac MD / Robenz	Zoetis Inc.	2
Nicarbazin / Bacitracin Premix	Phibro Animal Health Corp.	2
Albac 50 Type A Medicated Article	Zoetis Inc.	1
BMD and Coyden 25	Huvepharma EOOD	2
Avatec / Fortracin Premix	Zoetis Inc.	2
Baciferm / Amprol HI-E Premix	Zoetis Inc.	3
Albac / Coban	Zoetis Inc.	2
Bio-Cox / BMD	Zoetis Inc.	2
Coban / BMD	Zoetis Inc.	2
Baciferm / Bio-Cox	Zoetis Inc.	2
BMD / Stenorol	Huvepharma EOOD	2
BMD / Monteban	Zoetis Inc.	2
Baciferm / Albac, Baciferm / Monteban	Zoetis Inc.	2
BMD / Stenorol	Huvepharma EOOD	2
BMD / Maxiban	Elanco US Inc.	3
BMD / Coban	Elanco US Inc.	2
BMD and ChlorMax	Zoetis Inc.	2
Aviax / BMD	Phibro Animal Health Corp.	2
Avatec / Baciferm	Zoetis Inc.	2
BMD / Zoamix	Zoetis Inc.	2
BMD / Ivomec Premix for Swine	Boehringer lngelheim Animal Health USA Inc.	2
BMD / Deccox	Zoetis Inc.	2
Avatec / Baciferm	Zoetis Inc.	2
BMD / Maxiban	Zoetis Inc.	3
BMD and Zoamix	Zoetis Inc.	2
Bio-Cox / BMD	Zoetis Inc.	2
Pennitracin MD 50G	Pharmgate Inc.	1
BMD / Coban	Zoetis Inc.	2
BMD / Safe-Guard	Zoetis Inc.	2
Nicarb / Baciferm	Phibro Animal Health Corp.	2
Clinacox and BMD	Elanco US Inc.	2
BMD / Robenz	Zoetis Inc.	2
Amprol / BMD	Zoetis Inc.	2
Avatec / BMD	Zoetis Inc.	2
Avatec / Albac	Zoetis Inc.	2
Clinacox and BMD	Elanco US Inc.	2
Nicarb 25% plus BMD	Zoetis Inc.	2
Pennitracin MD and Maxiban	Pharmgate Inc.	3
Pennitracin MD and Coban	Pharmgate Inc.	2
BMD / Sacox	Huvepharma EOOD	2
Baciferm / Sacox	Huvepharma EOOD	2
BMD / Nicarmix 25	Planalquimica Industrial Ltda.	2
Albac / Bio-Cox	Zoetis Inc.	2
Albac / Amprol Hi-E	Zoetis Inc.	3
Albac / Sacox	Zoetis Inc.	2
Albac / Robenz	Zoetis Inc.	2
Albac / Deccox	Zoetis Inc.	2
Albac / Coyden 25	Zoetis Inc.	2
Albac 50 Type A Medicated Article	Zoetis Inc.	1
BMD-25, -30, -40, -50, -60, or -75 / Aureomycin -50, -70, -80, -90 or -100	Zoetis Inc.	2
BMD Pennchlor	Pharmgate Inc.	2
Albac 50 plus Nicarb	Zoetis Inc.	2
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment	Akorn Animal Health Inc.	3
ZoaShield and BMD	Elanco US Inc.	2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Epidermal growth factor receptor	Kinase	P00533	EGFR_HUMAN	IC50	5.27	DRUG MATRIX
Tyrosine-protein kinase Lck	Kinase	P06239	LCK_HUMAN	IC50	5.72	DRUG MATRIX
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT	Ki	5.87	DRUG MATRIX
Undecaprenyl-diphosphatase	Enzyme		UPPP_ECOLI	IC50	5.25	CHEMBL

External reference:

ID	Source
4017493	VUID
N0000145879	NUI
D00128	KEGG_DRUG
1405-89-6	SECONDARY_CAS_RN
11417	RXNORM
C0004599	UMLSCUI
CHEBI:28669	CHEBI
CHEMBL1200558	ChEMBL_ID
CHEMBL2096639	ChEMBL_ID
D001414	MESH_DESCRIPTOR_UI
DB00626	DRUGBANK_ID
1167	INN_ID
58H6RWO52I	UNII
10909430	PUBCHEM_CID
4241	MMSL
4242	MMSL
4917	MMSL
6046	MMSL
7622	MMSL
d01115	MMSL
CHEMBL2108831	ChEMBL_ID
55852-84-1	SECONDARY_CAS_RN
4017493	VANDF
4018101	VANDF
002798	NDDF
002799	NDDF
31707003	SNOMEDCT_US
370330005	SNOMEDCT_US
5220000	SNOMEDCT_US
96009006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Good Sense First Aid Antibiotic	HUMAN OTC DRUG LABEL	3	0113-0084	OINTMENT	400 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
Good Sense Triple Antibioticand Pain Relief	HUMAN OTC DRUG LABEL	4	0113-0679	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
good sense triple antibiotic	HUMAN OTC DRUG LABEL	4	0113-1140	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
Bacitracin Zinc and Polymyxin B Sulfate	HUMAN PRESCRIPTION DRUG LABEL	2	0168-0273	OINTMENT	500 1	OPHTHALMIC	ANDA	17 sections
AntibioticMaximum Strength	HUMAN OTC DRUG LABEL	3	0363-0018	OINTMENT	500 [iU]	TOPICAL	OTC Monograph Drug	13 sections
Bacitracin	HUMAN OTC DRUG LABEL	1	0363-0075	OINTMENT	500 [USPU]	TOPICAL	OTC monograph final	14 sections
Triple Antibiotic with Pain ReliefMaximum Strength	HUMAN OTC DRUG LABEL	4	0363-0123	OINTMENT	500 [USPU]	TOPICAL	OTC MONOGRAPH FINAL	13 sections
triple antibiotic	HUMAN OTC DRUG LABEL	3	0363-0539	OINTMENT	400 [USPU]	TOPICAL	OTC Monograph Drug	14 sections
First Aid Antibiotic	HUMAN OTC DRUG LABEL	4	0363-0841	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
ANTIBIOTICMaximum Strength	Human OTC Drug Label	3	0363-1331	OINTMENT	500 [iU]	TOPICAL	OTC Monograph Drug	13 sections
triple antibiotic	Human OTC Drug Label	3	0363-1332	OINTMENT	400 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Triple Antibiotic	HUMAN OTC DRUG LABEL	3	0363-2016	OINTMENT	400 [iU]	TOPICAL	OTC MONOGRAPH FINAL	14 sections
Walgreens Bacitracin Zinc	HUMAN OTC DRUG LABEL	1	0363-2075	OINTMENT	500 [USPU]	TOPICAL	OTC MONOGRAPH FINAL	14 sections
triple antibiotic pain relief	HUMAN OTC DRUG LABEL	4	0363-6790	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Maximum Strength Triple Antibiotic With Pain Relief	HUMAN OTC DRUG LABEL	4	0363-7872	OINTMENT	500 [USPU]	TOPICAL	OTC monograph final	11 sections
Walgreens Wal-Sporin First Aid Antibiotic	HUMAN OTC DRUG LABEL	2	0363-8821	OINTMENT	500 [USPU]	TOPICAL	OTC monograph final	12 sections
Triple Antibiotic Plus Pain Relief	HUMAN OTC DRUG LABEL	4	0363-8888	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	14 sections
Bacitracin Zinc, Neomycin Sulfate, and Polymyxin B Sulfate	HUMAN OTC DRUG LABEL	3	0404-0167	OINTMENT	400 [iU]	TOPICAL	OTC Monograph Drug	12 sections
Bacitracin Zinc	HUMAN OTC DRUG LABEL	1	0404-0170	OINTMENT	500 [iU]	TOPICAL	OTC Monograph Drug	14 sections
Bacitracin Zinc, Polymyxin B Sulfate, and Neomycin Sulfate	HUMAN OTC DRUG LABEL	3	0404-0171	OINTMENT	400 [iU]	TOPICAL	OTC Monograph Drug	12 sections
Bacitracin Zinc	HUMAN OTC DRUG LABEL	1	0404-0172	OINTMENT	500 [iU]	TOPICAL	OTC Monograph Drug	14 sections
Bacitracin	HUMAN OTC DRUG LABEL	1	0536-1256	OINTMENT	500 U	TOPICAL	OTC Monograph Drug	13 sections
Bacitracin Zinc	HUMAN OTC DRUG LABEL	1	0536-1263	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	13 sections
Triple Antibiotic	HUMAN OTC DRUG LABEL	3	0713-0268	OINTMENT	400 [USPU]	TOPICAL	OTC Monograph Drug	9 sections
Bacitracin	HUMAN OTC DRUG LABEL	1	0713-0280	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	9 sections
Triple Antibiotic Plus	HUMAN OTC DRUG LABEL	4	0713-0622	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	9 sections
Major Bacitracin	HUMAN OTC DRUG LABEL	1	0904-7023	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	14 sections
Major Bacitracin	HUMAN OTC DRUG LABEL	1	0904-7402	OINTMENT	500 [USPU]	TOPICAL	OTC Monograph Drug	14 sections
Major Triple Antibiotic	HUMAN OTC DRUG LABEL	3	0904-8805	OINTMENT	400 [USPU]	TOPICAL	OTC Monograph Drug	15 sections
triple antibiotic	HUMAN OTC DRUG LABEL	3	0924-5603	OINTMENT	400 [iU]	TOPICAL	OTC monograph final	11 sections

Ask DrugCentral

bacitracin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: