bacitracin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
281 1405-87-4

Description:

MoleculeDescription

Synonyms:

  • bacitracin
  • baciguent
  • bacillichin
  • bacilliquin
  • bacitracin zinc
  • bacitracin methylene disalicylate
A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)
  • Molecular weight: 5648.77
  • Formula: C261H406N68O64S4
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 530.87
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 29, 1948 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 405.02 17.78 215 2459 250795 50351655
Lymphatic disorder 28.63 17.78 6 2668 349 50602101

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 45.87 18.47 41 2422 68365 29503699
Renal injury 20.65 18.47 12 2451 10190 29561874

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 207.92 16.74 153 4272 237662 64256645
Lymphatic disorder 27.77 16.74 6 4419 310 64493997
Renal injury 23.23 16.74 14 4411 15415 64478892
Unevaluable event 22.17 16.74 22 4403 50467 64443840
Anaphylactic reaction 21.48 16.74 25 4400 68639 64425668
Tachypnoea 18.46 16.74 15 4410 26556 64467751
Mental status changes 17.05 16.74 21 4404 61141 64433166

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D06AX05 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
ANTIBIOTICS FOR TOPICAL USE
Other antibiotics for topical use
ATC J01XX10 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Other antibacterials
ATC R02AB04 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antibiotics
FDA PE N0000008479 Decreased Cell Wall Synthesis & Repair
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:176497 geroprotectors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Keratitis indication 5888003 DOID:4677
Blepharoconjunctivitis indication 68659002 DOID:2456
Corneal abrasion indication 85848002
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Superficial Ocular Infection indication
Minor Bacterial Skin Infections indication
Dacryocystitis off-label use 85777005 DOID:9938
Corneal ulcer off-label use 91514001 DOID:8463
Bacterial conjunctivitis off-label use 128350005 DOID:9700
Meibomianitis off-label use 309779001
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Bacterial septicemia contraindication 10001005 DOID:0040085
Shock contraindication 27942005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Tuberculosis of eye contraindication 49107007
Diabetes mellitus contraindication 73211009 DOID:9351
Third degree burn injury contraindication 80247002
Decreased respiratory function contraindication 80954004
Oliguria contraindication 83128009
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Open wound contraindication 125643001
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Telangiectasia disorder contraindication 247479008
Injury of eye region contraindication 282752000
Pregnancy, function contraindication 289908002
Viral eye infection contraindication 312132001
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Vaccinia keratitis contraindication 397552005
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Necrotic enteritis caused or complicated by Clostridium species Indication
Cattle To increase rate of weight gain Indication
Cattle To improve feed efficiency Indication
Cattle To increases egg production Indication
Chickens Necrotic enteritis caused or complicated by Clostridium species Indication
Chickens To increase rate of weight gain Indication
Chickens Improves feed efficiency during the first seven months of production Indication
Chickens Increases egg productionduring the first seven months of production Indication
Pheasants To increase rate of weight gain Indication
Pheasants To improve feed efficiency Indication
Quail To increase rate of weight gain Indication
Quail To improve feed efficiency Indication
Swine Enteritis caused by Clostridium perfringens Indication
Swine Swine dysentery associated with Treponema hyodysenteriae Indication
Swine To increase rate of weight gain Indication
Swine To improve feed efficiency Indication
Turkeys Enteritis Indication
Turkeys To increase rate of weight gain Indication
Turkeys To improve feed efficiency Indication

🐶 Veterinary products

ProductApplicantIngredients
Amprol HI-E Plus Huvepharma EOOD 3
Albac / Deccox, Broiler Finisher Medicated Zoetis Inc. 2
BMD 30 Granular A, BMD 50 Granular A, BMD 30, BMD 50, BMD 60 Zoetis Inc. 1
Baciferm - 10, Baciferm - 25, Baciferm - 40, Baciferm - 50 Zoetis Inc. 1
Coban plus Baciferm Elanco US Inc. 2
Coban plus BMD Elanco US Inc. 2
Coyden 25 with Bacitracin Zinc Huvepharma EOOD 2
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment Dechra, Ltd. 4
Bac-Neo-Poly Ophthalmic Ointment, Vetropolycin Ophthalmic Ointment Dechra, Ltd. 3
Entromycin Powder Zoetis Inc. 2
Mycitracin Sterile Ophthalmic Ointment Zoetis Inc. 3
Soluble Fortracin Concentrate Zoetis Inc. 1
Baciferm Soluble 50 Zoetis Inc. 1
BMD Soluble Zoetis Inc. 1
Cortisporin Veterinary Ophthalmic Ointment Intervet Inc. 4
Neosporin Ophthalmic Ointment Intervet Inc. 3
Robenz Plus Zn Bacitracin Zoetis Inc. 2
Bac MD / Robenz Zoetis Inc. 2
Nicarbazin / Bacitracin Premix Phibro Animal Health Corp. 2
Albac 50 Type A Medicated Article Zoetis Inc. 1
BMD and Coyden 25 Huvepharma EOOD 2
Avatec / Fortracin Premix Zoetis Inc. 2
Baciferm / Amprol HI-E Premix Zoetis Inc. 3
Albac / Coban Zoetis Inc. 2
Bio-Cox / BMD Zoetis Inc. 2
Coban / BMD Zoetis Inc. 2
Baciferm / Bio-Cox Zoetis Inc. 2
BMD / Stenorol Huvepharma EOOD 2
BMD / Monteban Zoetis Inc. 2
Baciferm / Albac, Baciferm / Monteban Zoetis Inc. 2
BMD / Stenorol Huvepharma EOOD 2
BMD / Maxiban Elanco US Inc. 3
BMD / Coban Elanco US Inc. 2
BMD and ChlorMax Zoetis Inc. 2
Aviax / BMD Phibro Animal Health Corp. 2
Avatec / Baciferm Zoetis Inc. 2
BMD / Zoamix Zoetis Inc. 2
BMD / Ivomec Premix for Swine Boehringer lngelheim Animal Health USA Inc. 2
BMD / Deccox Zoetis Inc. 2
Avatec / Baciferm Zoetis Inc. 2
BMD / Maxiban Zoetis Inc. 3
BMD and Zoamix Zoetis Inc. 2
Bio-Cox / BMD Zoetis Inc. 2
Pennitracin MD 50G Pharmgate Inc. 1
BMD / Coban Zoetis Inc. 2
BMD / Safe-Guard Zoetis Inc. 2
Nicarb / Baciferm Phibro Animal Health Corp. 2
Clinacox and BMD Elanco US Inc. 2
BMD / Robenz Zoetis Inc. 2
Amprol / BMD Zoetis Inc. 2
Avatec / BMD Zoetis Inc. 2
Avatec / Albac Zoetis Inc. 2
Clinacox and BMD Elanco US Inc. 2
Nicarb 25% plus BMD Zoetis Inc. 2
Pennitracin MD and Maxiban Pharmgate Inc. 3
Pennitracin MD and Coban Pharmgate Inc. 2
BMD / Sacox Huvepharma EOOD 2
Baciferm / Sacox Huvepharma EOOD 2
BMD / Nicarmix 25 Planalquimica Industrial Ltda. 2
Albac / Bio-Cox Zoetis Inc. 2
Albac / Amprol Hi-E Zoetis Inc. 3
Albac / Sacox Zoetis Inc. 2
Albac / Robenz Zoetis Inc. 2
Albac / Deccox Zoetis Inc. 2
Albac / Coyden 25 Zoetis Inc. 2
Albac 50 Type A Medicated Article Zoetis Inc. 1
BMD-25, -30, -40, -50, -60, or -75 / Aureomycin -50, -70, -80, -90 or -100 Zoetis Inc. 2
BMD Pennchlor Pharmgate Inc. 2
Albac 50 plus Nicarb Zoetis Inc. 2
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Ophthalmic Ointment Akorn Animal Health Inc. 3
ZoaShield and BMD Elanco US Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Epidermal growth factor receptor Kinase IC50 5.27 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 5.72 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 5.87 DRUG MATRIX
Undecaprenyl-diphosphatase Unclassified IC50 5.25 CHEMBL

External reference:

IDSource
4017493 VUID
N0000145879 NUI
D00128 KEGG_DRUG
1405-89-6 SECONDARY_CAS_RN
11417 RXNORM
C0004599 UMLSCUI
CHEBI:28669 CHEBI
CHEMBL1200558 ChEMBL_ID
CHEMBL2096639 ChEMBL_ID
D001414 MESH_DESCRIPTOR_UI
DB00626 DRUGBANK_ID
1167 INN_ID
55852-84-1 SECONDARY_CAS_RN
58H6RWO52I UNII
10909430 PUBCHEM_CID
4241 MMSL
4242 MMSL
4917 MMSL
6046 MMSL
7622 MMSL
d01115 MMSL
002798 NDDF
002799 NDDF
4017493 VANDF
4018101 VANDF
CHEMBL2108831 ChEMBL_ID
31707003 SNOMEDCT_US
370330005 SNOMEDCT_US
5220000 SNOMEDCT_US
96009006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Good Sense First Aid Antibiotic HUMAN OTC DRUG LABEL 3 0113-0084 OINTMENT 400 [USPU] TOPICAL OTC monograph final 13 sections
Good Sense Triple Antibioticand Pain Relief HUMAN OTC DRUG LABEL 4 0113-0679 OINTMENT 500 [USPU] TOPICAL OTC monograph final 13 sections
basic care first aid antibiotic HUMAN OTC DRUG LABEL 3 0113-0701 OINTMENT 400 [USPU] TOPICAL OTC monograph final 13 sections
good sense triple antibiotic HUMAN OTC DRUG LABEL 4 0113-1140 OINTMENT 500 [USPU] TOPICAL OTC monograph final 13 sections
Basic Care First Aid Antibiotic Plus Pain Relief HUMAN OTC DRUG LABEL 4 0113-7679 OINTMENT 500 [USPU] TOPICAL OTC monograph final 13 sections
Bacitracin Zinc and Polymyxin B Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0168-0273 OINTMENT 500 1 OPHTHALMIC ANDA 17 sections
Kaiser PermanenteDouble antibiotic HUMAN OTC DRUG LABEL 2 0179-8707 OINTMENT 500 [USPU] TOPICAL OTC monograph final 14 sections
AntibioticMaximum Strength HUMAN OTC DRUG LABEL 3 0363-0018 OINTMENT 500 [iU] TOPICAL OTC monograph final 13 sections
Bacitracin HUMAN OTC DRUG LABEL 1 0363-0075 OINTMENT 500 [USPU] TOPICAL OTC monograph final 14 sections
Triple Antibiotic with Pain ReliefMaximum Strength HUMAN OTC DRUG LABEL 4 0363-0123 OINTMENT 500 [USPU] TOPICAL OTC MONOGRAPH FINAL 13 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-0179 OINTMENT 400 [iU] TOPICAL OTC monograph final 13 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 400 [USPU] TOPICAL OTC monograph final 15 sections
triple antibiotic HUMAN OTC DRUG LABEL 3 0363-0539 OINTMENT 400 [USPU] TOPICAL OTC monograph final 15 sections
First Aid Antibiotic HUMAN OTC DRUG LABEL 4 0363-0841 OINTMENT 500 [USPU] TOPICAL OTC monograph final 13 sections
Walgreens Triple Antibiotic HUMAN OTC DRUG LABEL 3 0363-2016 OINTMENT 400 [iU] TOPICAL OTC MONOGRAPH FINAL 14 sections
Walgreens Bacitracin Zinc HUMAN OTC DRUG LABEL 1 0363-2075 OINTMENT 500 [USPU] TOPICAL OTC MONOGRAPH FINAL 14 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 4 0363-2900 OINTMENT 500 [iU] TOPICAL OTC monograph final 13 sections
Walgreens Maximum Strength Triple Antibiotic With Pain Relief HUMAN OTC DRUG LABEL 4 0363-7872 OINTMENT 500 [USPU] TOPICAL OTC monograph final 11 sections
Walgreens Wal-Sporin First Aid Antibiotic HUMAN OTC DRUG LABEL 2 0363-8821 OINTMENT 500 [USPU] TOPICAL OTC monograph final 12 sections
Triple Antibiotic Plus Pain Relief HUMAN OTC DRUG LABEL 4 0363-8888 OINTMENT 500 [USPU] TOPICAL OTC MONOGRAPH FINAL 14 sections
Schein Triple Antibiotic HUMAN OTC DRUG LABEL 3 0404-0360 OINTMENT 400 [iU] TOPICAL OTC monograph final 8 sections
Schein Bacitracin HUMAN OTC DRUG LABEL 1 0404-0400 OINTMENT 500 [iU] TOPICAL OTC monograph final 8 sections
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc HUMAN PRESCRIPTION DRUG LABEL 3 0404-7194 OINTMENT 400 [USPU] OPHTHALMIC ANDA 19 sections
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 4 0404-7195 OINTMENT 400 [USPU] OPHTHALMIC ANDA 19 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0472-0179 OINTMENT 400 [iU] TOPICAL OTC monograph final 14 sections
Bacitracin Zinc HUMAN OTC DRUG LABEL 1 0472-1105 OINTMENT 500 [USPU] TOPICAL OTC monograph final 14 sections
North Triple Antibiotic HUMAN OTC DRUG LABEL 3 0498-0740 OINTMENT 400 [iU] TOPICAL OTC monograph final 13 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 3 0498-0750 OINTMENT 400 [iU] TOPICAL OTC monograph final 13 sections
Double Antibiotic HUMAN OTC DRUG LABEL 2 0536-1174 OINTMENT 500 [USPU] TOPICAL OTC MONOGRAPH FINAL 14 sections
Bacitracin HUMAN OTC DRUG LABEL 1 0536-1256 OINTMENT 500 U TOPICAL OTC monograph final 13 sections