Stem definition | Drug id | CAS RN |
---|---|---|
281 | 1405-87-4 |
Molecule | Description |
---|---|
Synonyms:
|
A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)
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None
None
Date | Agency | Company | Orphan |
---|---|---|---|
July 29, 1948 | FDA | PHARMACIA AND UPJOHN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 967.44 | 16.74 | 449 | 3602 | 243376 | 46438635 |
Rash | 56.19 | 16.74 | 106 | 3945 | 356406 | 46325605 |
Vulval cancer stage III | 40.67 | 16.74 | 6 | 4045 | 23 | 46681988 |
Lymphatic disorder | 25.80 | 16.74 | 6 | 4045 | 341 | 46681670 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 121.03 | 17.62 | 80 | 3053 | 68439 | 29880906 |
Dermatitis contact | 34.81 | 17.62 | 13 | 3120 | 3218 | 29946127 |
Source | Code | Description |
---|---|---|
ATC | D06AX05 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use |
ATC | J01XX10 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Other antibacterials |
ATC | R02AB04 | RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antibiotics |
FDA PE | N0000008479 | Decreased Cell Wall Synthesis & Repair |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000891 | Anti-Infective Agents, Local |
CHEBI has role | CHEBI:33282 | antibacterials |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Keratitis | indication | 5888003 | DOID:4677 |
Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
Corneal abrasion | indication | 85848002 | |
Infective blepharitis | indication | 312219000 | |
Bacterial keratitis | indication | 314557000 | |
Superficial Ocular Infection | indication | ||
Minor Bacterial Skin Infections | indication | ||
Dacryocystitis | off-label use | 85777005 | DOID:9938 |
Corneal ulcer | off-label use | 91514001 | DOID:8463 |
Bacterial conjunctivitis | off-label use | 128350005 | DOID:9700 |
Meibomianitis | off-label use | 309779001 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Herpes simplex keratitis | contraindication | 9389005 | |
Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
Shock | contraindication | 27942005 | |
Herpes simplex dendritic keratitis | contraindication | 29943008 | |
Fungal infection of eye | contraindication | 31194008 | |
Severe myopia | contraindication | 34187009 | |
Tuberculosis of eye | contraindication | 49107007 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Third degree burn injury | contraindication | 80247002 | |
Decreased respiratory function | contraindication | 80954004 | |
Oliguria | contraindication | 83128009 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Krukenberg spindle | contraindication | 85430004 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Open wound | contraindication | 125643001 | |
Eye infection | contraindication | 128351009 | |
Seizure disorder | contraindication | 128613002 | |
Bacterial infection of eye | contraindication | 128984004 | |
Heart block | contraindication | 233916004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Telangiectasia disorder | contraindication | 247479008 | |
Injury of eye region | contraindication | 282752000 | |
Pregnancy, function | contraindication | 289908002 | |
Viral eye infection | contraindication | 312132001 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Vaccinia keratitis | contraindication | 397552005 | |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 | |
Denuded skin | contraindication | 418242004 |
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor | Kinase | IC50 | 5.27 | DRUG MATRIX | |||||
Tyrosine-protein kinase Lck | Kinase | IC50 | 5.72 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.87 | DRUG MATRIX |
ID | Source |
---|---|
58H6RWO52I | UNII |
4017493 | VUID |
N0000145879 | NUI |
D00128 | KEGG_DRUG |
1405-89-6 | SECONDARY_CAS_RN |
4017493 | VANDF |
4018101 | VANDF |
C0718794 | UMLSCUI |
CHEBI:28669 | CHEBI |
CHEMBL1200558 | ChEMBL_ID |
CHEMBL2096639 | ChEMBL_ID |
DB00626 | DRUGBANK_ID |
D001414 | MESH_DESCRIPTOR_UI |
10909430 | PUBCHEM_CID |
1167 | INN_ID |
11417 | RXNORM |
4241 | MMSL |
4242 | MMSL |
4917 | MMSL |
6046 | MMSL |
7622 | MMSL |
d01115 | MMSL |
002798 | NDDF |
002799 | NDDF |
31707003 | SNOMEDCT_US |
370330005 | SNOMEDCT_US |
5220000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Good Sense First Aid Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0113-0084 | OINTMENT | 400 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Good Sense Triple Antibioticand Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-0679 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 13 sections |
basic care first aid antibiotic | HUMAN OTC DRUG LABEL | 3 | 0113-0701 | OINTMENT | 400 [USPU] | TOPICAL | OTC monograph final | 13 sections |
good sense triple antibiotic | HUMAN OTC DRUG LABEL | 4 | 0113-1140 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Basic Care First Aid Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-7679 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Bacitracin Zinc | HUMAN OTC DRUG LABEL | 1 | 0168-0011 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 9 sections |
Double Antibiotic | HUMAN OTC DRUG LABEL | 2 | 0168-0021 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 12 sections |
Bacitracin Zinc | HUMAN OTC DRUG LABEL | 1 | 0168-0111 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 9 sections |
Bacitracin Zinc and Polymyxin B Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0168-0273 | OINTMENT | 500 1 | OPHTHALMIC | ANDA | 17 sections |
KAISER PERMANENTEBacitracin Zinc | HUMAN OTC DRUG LABEL | 1 | 0179-8012 | OINTMENT | 500 [iU] | TOPICAL | OTC monograph final | 14 sections |
Kaiser PermanenteDouble antibiotic | HUMAN OTC DRUG LABEL | 2 | 0179-8707 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 14 sections |
AntibioticMaximum Strength | HUMAN OTC DRUG LABEL | 3 | 0363-0018 | OINTMENT | 500 [iU] | TOPICAL | OTC monograph final | 13 sections |
Bacitracin | HUMAN OTC DRUG LABEL | 1 | 0363-0075 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 14 sections |
Triple Antibiotic with Pain ReliefMaximum Strength | HUMAN OTC DRUG LABEL | 4 | 0363-0123 | OINTMENT | 500 [USPU] | TOPICAL | OTC MONOGRAPH FINULLL | 13 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0179 | OINTMENT | 400 [iU] | TOPICAL | OTC MONOGRAPH FINULLL | 13 sections |
triple antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-0539 | OINTMENT | 400 [USPU] | TOPICAL | OTC monograph final | 13 sections |
First Aid Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-0841 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 13 sections |
Walgreens Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0363-2016 | OINTMENT | 400 [iU] | TOPICAL | OTC MONOGRAPH FINULLL | 14 sections |
Walgreens Bacitracin Zinc | HUMAN OTC DRUG LABEL | 1 | 0363-2075 | OINTMENT | 500 [USPU] | TOPICAL | OTC MONOGRAPH FINULLL | 14 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-2900 | OINTMENT | 500 [iU] | TOPICAL | OTC monograph final | 13 sections |
Walgreens Maximum Strength Triple Antibiotic With Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-7872 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 11 sections |
Walgreens Wal-Sporin First Aid Antibiotic | HUMAN OTC DRUG LABEL | 2 | 0363-8821 | OINTMENT | 500 [USPU] | TOPICAL | OTC monograph final | 12 sections |
Triple Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-8888 | OINTMENT | 500 [USPU] | TOPICAL | OTC MONOGRAPH FINULLL | 14 sections |
Schein Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0404-0360 | OINTMENT | 400 [iU] | TOPICAL | OTC monograph final | 8 sections |
Schein Bacitracin | HUMAN OTC DRUG LABEL | 1 | 0404-0400 | OINTMENT | 500 [iU] | TOPICAL | OTC monograph final | 8 sections |
Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0404-7194 | OINTMENT | 400 [USPU] | OPHTHALMIC | ANDA | 19 sections |
Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0404-7195 | OINTMENT | 400 [USPU] | OPHTHALMIC | ANDA | 19 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0472-0179 | OINTMENT | 400 [iU] | TOPICAL | OTC MONOGRAPH FINULLL | 14 sections |
Bacitracin Zinc | HUMAN OTC DRUG LABEL | 1 | 0472-1105 | OINTMENT | 500 [USPU] | TOPICAL | OTC MONOGRAPH FINULLL | 14 sections |
North Triple Antibiotic | HUMAN OTC DRUG LABEL | 3 | 0498-0740 | OINTMENT | 400 [iU] | TOPICAL | OTC monograph final | 13 sections |