gramicidin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
naturally occurring antibiotics (undefined group) 4794 1405-97-6

Description:

MoleculeDescription

Synonyms:

  • gramicidin
  • gramicidins
  • gramoderm
  • gramicidin D
  • gramicidine
  • gramicidin Dubos
A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.
  • Molecular weight: 9354.60
  • Formula: C491H701N97O87
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 548.99
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 3, 1968 FDA MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 117.59 44.84 21 175 7184 46678682
Drug ineffective 45.51 44.84 30 166 677808 46008058

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC R02AB30 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antibiotics
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Blepharoconjunctivitis indication 68659002 DOID:2456
Bacterial conjunctivitis indication 128350005 DOID:9700
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Superficial Ocular Infection indication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosine-protein kinase Lck Kinase IC50 5.96 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.48 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 6.11 DRUG MATRIX
Endothelin-1 receptor GPCR Ki 5.74 DRUG MATRIX
Melanocortin receptor 4 GPCR Ki 5.50 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.72 DRUG MATRIX
Substance-K receptor GPCR Ki 5.82 DRUG MATRIX
Bacterial cell membrane Cell membrane MEMBRANE PERMEABILIZER UNKNOWN DRUG LABEL
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 5.29 DRUG MATRIX

External reference:

IDSource
D04369 KEGG_DRUG
4018774 VUID
N0000147077 NUI
4018774 VANDF
C0018165 UMLSCUI
CHEBI:5530 CHEBI
CHEMBL1201469 ChEMBL_ID
CHEMBL557217 ChEMBL_ID
DB00027 DRUGBANK_ID
D006096 MESH_DESCRIPTOR_UI
2025 INN_ID
5IE62321P4 UNII
16130140 PUBCHEM_CID
5011 RXNORM
4800 MMSL
002801 NDDF
004423 NDDF
387524003 SNOMEDCT_US
91479004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Neomycin and Polymyxin B Sulfates and Gramicidin HUMAN PRESCRIPTION DRUG LABEL 3 21695-528 SOLUTION/ DROPS 0.03 mg OPHTHALMIC ANDA 19 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN HUMAN PRESCRIPTION DRUG LABEL 3 24208-790 SOLUTION/ DROPS 0.03 mg OPHTHALMIC ANDA 19 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN HUMAN PRESCRIPTION DRUG LABEL 3 50090-0247 SOLUTION/ DROPS 0.03 mg OPHTHALMIC ANDA 18 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN HUMAN PRESCRIPTION DRUG LABEL 3 54868-6253 SOLUTION/ DROPS 0.03 mg OPHTHALMIC ANDA 18 sections
NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN HUMAN PRESCRIPTION DRUG LABEL 3 55045-1194 SOLUTION/ DROPS 0.03 mg OPHTHALMIC ANDA 18 sections