ethacridine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
acridine derivatives	3194	442-16-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ethacridine
etakridin
ethacridine lactate

A topically applied anti-infective agent.

Molecular weight: 253.31
Formula: C15H15N3O
CLOGP: 3.37
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 74.16
ALOGS: -3.58
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR1B,ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BLK,BMX,BRAF,BTK,CAMK2B,CAMK2D,CAMK2G,CDK1,CDK16,CDK19,CDK4,CDK5,CDK9,CHEK1,CLK4,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,ERBB4,FGFR1,FGFR4,FLT1,FLT3,FLT4,FYN,GAK,GRK1,GRK2,GRK3,GSK3A,GSK3B,IGF1R,IKBKB,INSR,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,LCK,LYN,MAP2K1,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP3K8,MAP4K1,MAP4K2,MAP4K3,MAP4K5,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MET,MINK1,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PIM3,PLK1,PRKCD,PRKDC,PTK2,SGK1,SIK2,SIK3,SRC,STK10,STK33,SYK,TEK,TGFBR1,TNIK,TTK,TYRO3,ULK1,ULK2,ZAP70	122
kinase-selectivity-class	ACVR2A,ALK,AURKA,AXL,BRAF,CAMK2D,CDK9,DDR1,DYRK1B,ERBB2,FLT3,GRK2,IKBKB,JAK1,MAP2K3,MAP2K6,MAP3K10,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAPK12,MAPK7,MARK4,PDK4,PRKCD,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1	34
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macrocephaly	24.83	23.24	5	10	113	113825

Pharmacologic Action:

Source	Code	Description
ATC	B05CA08	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Antiinfectives
ATC	D08AA01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Acridine derivatives
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local

Related Drugs by ATC class:

B05CA Antiinfectives 8 drugs

cetylpyridinium chlorhexidine mandelic acid neomycin nitrofurazone noxytiolin sulfamethizole taurolidine

D08AA Acridine derivatives 2 drugs

aminoacridine euflavine

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.96	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Telomerase reverse transcriptase	Enzyme	O14746	TERT_HUMAN		IC50	5.09		CHEMBL
Reverse transcriptase/RNaseH	Enzyme		Q72547_9HIV1		IC50	4.70		CHEMBL
Reverse transcriptase	Enzyme		Q9WKE8_9HIV1		IC50	4.70		CHEMBL

External reference:

ID	Source
N0000167269	NUI
D07924	KEGG_DRUG
6402-23-9	SECONDARY_CAS_RN
C0014960	UMLSCUI
CHEBI:135032	CHEBI
CHEMBL94007	ChEMBL_ID
DB13190	DRUGBANK_ID
CHEMBL2355915	ChEMBL_ID
D004975	MESH_DESCRIPTOR_UI
2017	PUBCHEM_CID
1783	INN_ID
WIX85M1A6R	UNII
4106	RXNORM
005540	NDDF
005541	NDDF
711320003	SNOMEDCT_US
715469007	SNOMEDCT_US

Pharmaceutical products:

None