arbekacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, kanamycin and bekanamycin derivatives (obtained from Streptomyces kanamyceticus) 235 51025-85-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • arbekacin
  • AHB-DKB
  • HABA-DKB
  • habekacin
  • Molecular weight: 552.63
  • Formula: C22H44N6O10
  • CLOGP: -3.64
  • LIPINSKI: 3
  • HAC: 16
  • HDO: 11
  • TPSA: 297.27
  • ALOGS: -1.13
  • ROTB: 10

Drug dosage:

DoseUnitRoute
0.20 g P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.28 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.46 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 18.30 17.59 3 3 28421 50576697

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01GB12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
AMINOGLYCOSIDE ANTIBACTERIALS
Other aminoglycosides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:48001 protein synthesis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.04 acidic
pKa2 12.98 acidic
pKa3 13.55 acidic
pKa4 13.58 acidic
pKa5 9.4 Basic
pKa6 8.7 Basic
pKa7 7.75 Basic
pKa8 7.15 Basic
pKa9 6.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07462 KEGG_DRUG
26397 RXNORM
C1148057 UMLSCUI
CHEBI:37922 CHEBI
84G PDB_CHEM_ID
CHEMBL426926 ChEMBL_ID
DB06696 DRUGBANK_ID
C031986 MESH_SUPPLEMENTAL_RECORD_UI
7345 IUPHAR_LIGAND_ID
5914 INN_ID
G7V6SLI20L UNII
68682 PUBCHEM_CID
007488 NDDF
725569009 SNOMEDCT_US

Pharmaceutical products:

None