chlorhexidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
597 55-56-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chlorhexidine hydrochloride
  • chlorhexidine
  • chlorohex
  • chlorohexidine
  • chlorhexidine gluconate
  • chlorhexidine acetate
A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
  • Molecular weight: 505.45
  • Formula: C22H30Cl2N10
  • CLOGP: 4.81
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 10
  • TPSA: 167.58
  • ALOGS: -4.29
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 17, 1976 FDA MOLNLYCKE HLTH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2474.88 16.42 1974 97021 131859 56061213
Folliculitis 2216.29 16.42 1313 97682 53666 56139406
Muscle injury 2208.78 16.42 1289 97706 51211 56141861
Irritable bowel syndrome 2067.96 16.42 1361 97634 67097 56125975
Lower respiratory tract infection 2001.54 16.42 1637 97358 113157 56079915
Impaired healing 1695.29 16.42 1324 97671 85517 56107555
Sleep disorder due to general medical condition, insomnia type 1590.48 16.42 975 98020 42363 56150709
Blister 1500.65 16.42 1358 97637 107529 56085543
Ill-defined disorder 1373.88 16.42 1062 97933 67481 56125591
Stomatitis 1352.34 16.42 1343 97652 119467 56073605
Gastrointestinal disorder 1306.17 16.42 1277 97718 111425 56081647
Toxicity to various agents 1038.02 16.42 1598 97397 222966 55970106
Sinusitis 1033.35 16.42 1490 97505 196091 55996981
Peripheral swelling 960.47 16.42 1580 97415 233146 55959926
Helicobacter infection 909.81 16.42 863 98132 72405 56120667
Duodenal ulcer perforation 898.56 16.42 831 98164 67511 56125561
Therapeutic product effect decreased 847.76 16.42 1252 97743 168200 56024872
Confusional state 831.99 16.42 1387 97608 206768 55986304
Nasopharyngitis 783.05 16.42 1396 97599 219563 55973509
Pruritus 765.46 16.42 1704 97291 314919 55878153
Infection 757.42 16.42 1302 97693 198904 55994168
Joint swelling 697.10 16.42 1557 97438 288243 55904829
Drug abuse 674.06 16.42 707 98288 66903 56126169
Weight increased 652.41 16.42 1321 97674 228382 55964690
Hypersensitivity 651.94 16.42 1409 97586 254999 55938073
Swelling 649.33 16.42 1352 97643 238419 55954653
Pericarditis 646.58 16.42 874 98121 108049 56085023
Anti-cyclic citrullinated peptide antibody positive 587.89 16.42 793 98202 97807 56095265
Contusion 493.75 16.42 842 98153 127588 56065484
Discomfort 487.58 16.42 885 98110 140876 56052196
Nausea 450.40 16.42 411 98584 763767 55429305
Muscle spasticity 436.07 16.42 326 98669 19634 56173438
Hand deformity 429.02 16.42 813 98182 133679 56059393
Cardio-respiratory arrest 416.58 16.42 500 98495 54821 56138251
Ear pain 408.21 16.42 377 98618 30513 56162559
Hepatic enzyme increased 398.85 16.42 910 98085 170474 56022598
Night sweats 392.78 16.42 421 98574 40792 56152280
Wound 384.61 16.42 791 98204 138013 56055059
Synovitis 379.20 16.42 860 98135 160445 56032627
Intentional overdose 377.33 16.42 529 98466 67588 56125484
Glossodynia 371.97 16.42 825 98170 151633 56041439
Body temperature increased 371.58 16.42 375 98620 33867 56159205
Pemphigus 359.35 16.42 829 98166 156383 56036689
Fall 355.63 16.42 95 98900 357415 55835657
Rash 314.48 16.42 1699 97296 491348 55701724
Systemic lupus erythematosus 300.44 16.42 843 98152 179235 56013837
Alcohol interaction 299.44 16.42 123 98872 2210 56190862
Contraindicated product administered 297.12 16.42 858 98137 185428 56007644
Respiratory disorder 294.22 16.42 330 98665 33627 56159445
Arthropathy 288.71 16.42 890 98105 199385 55993687
Pyrexia 265.93 16.42 1442 97553 417331 55775741
Pneumonia 259.67 16.42 202 98793 406896 55786176
Malaise 254.93 16.42 167 98828 367693 55825379
Infusion related reaction 237.45 16.42 857 98138 208074 55984998
Product dose omission issue 232.70 16.42 40 98955 204713 55988359
Cough 231.56 16.42 84 98911 259877 55933195
Dizziness 226.95 16.42 197 98798 375943 55817129
Pain in extremity 225.75 16.42 121 98874 297310 55895762
Suspected suicide 223.49 16.42 132 98863 5334 56187738
Anaemia 208.65 16.42 105 98890 267406 55925666
Suicide attempt 188.28 16.42 353 98642 57483 56135589
Overdose 171.90 16.42 491 98504 105339 56087733
Dehydration 158.02 16.42 42 98953 158783 56034289
Urinary tract infection 151.00 16.42 121 98874 240392 55952680
Alcohol poisoning 148.64 16.42 70 98925 1765 56191307
Urticaria 147.96 16.42 574 98421 144102 56048970
Injection site pain 144.27 16.42 18 98977 117100 56075972
Acute kidney injury 142.72 16.42 128 98867 240635 55952437
Weight decreased 139.10 16.42 131 98864 240583 55952489
Therapeutic product effect incomplete 139.00 16.42 13 98982 106018 56087054
Off label use 136.45 16.42 511 98484 555669 55637403
Abdominal discomfort 136.38 16.42 894 98101 276380 55916692
Constipation 135.21 16.42 95 98900 201848 55991224
Sleep disorder 132.02 16.42 336 98659 67327 56125745
Feeling abnormal 129.76 16.42 37 98958 133565 56059507
Blood pressure increased 124.00 16.42 50 98945 145126 56047946
Haemoglobin decreased 123.34 16.42 41 98954 134096 56058976
Alcohol use 121.58 16.42 63 98932 1962 56191110
Psoriasis 119.82 16.42 12 98983 92680 56100392
Decreased appetite 118.97 16.42 126 98869 219105 55973967
Alopecia 118.48 16.42 902 98093 292556 55900516
Drug intolerance 118.35 16.42 834 98161 263984 55929088
Arthralgia 116.84 16.42 1371 97624 500298 55692774
Bronchitis 114.96 16.42 28 98967 112283 56080789
Insomnia 110.17 16.42 644 98351 191216 56001856
Condition aggravated 109.87 16.42 281 98714 344617 55848455
Myocardial infarction 107.97 16.42 17 98978 92853 56100219
Gait disturbance 107.76 16.42 78 98917 163243 56029829
Cerebrovascular accident 107.13 16.42 22 98973 99248 56093824
Cardiac failure congestive 106.77 16.42 14 98981 87706 56105366
Myalgia 105.57 16.42 50 98945 131975 56061097
Drug hypersensitivity 100.71 16.42 208 98787 274997 55918075
Loss of personal independence in daily activities 99.00 16.42 13 98982 81356 56111716
Arthritis 98.16 16.42 27 98968 99825 56093247
Syncope 97.85 16.42 34 98961 108165 56084907
Influenza 95.07 16.42 25 98970 95236 56097836
Alcohol abuse 94.70 16.42 53 98942 1931 56191141
White blood cell count decreased 94.34 16.42 52 98943 125938 56067134
Diarrhoea 93.95 16.42 698 98297 637809 55555263
Chills 93.20 16.42 32 98963 102572 56090500
Thrombocytopenia 92.57 16.42 63 98932 136161 56056911
Hyponatraemia 90.82 16.42 33 98962 102106 56090966
Platelet count decreased 90.24 16.42 37 98958 106346 56086726
Respiratory arrest 89.93 16.42 179 98816 30446 56162626
Renal failure 89.65 16.42 41 98954 110459 56082613
Maternal exposure timing unspecified 89.23 16.42 75 98920 5348 56187724
Neutropenia 89.06 16.42 88 98907 158079 56034993
Lip dry 88.36 16.42 97 98898 9643 56183429
Injection site erythema 86.01 16.42 16 98979 77432 56115640
Inappropriate schedule of product administration 84.91 16.42 21 98974 83366 56109706
Medication error 84.40 16.42 212 98783 42123 56150949
Hypertension 83.25 16.42 192 98803 244086 55948986
Upper respiratory tract infection 82.97 16.42 13 98982 71275 56121797
Gastrooesophageal reflux disease 79.09 16.42 24 98971 83233 56109839
Balance disorder 78.44 16.42 19 98976 76501 56116571
Pancytopenia 78.30 16.42 29 98966 88686 56104386
Pain 77.03 16.42 1612 97383 661572 55531500
Headache 76.58 16.42 623 98372 558421 55634651
Pulmonary embolism 76.24 16.42 47 98948 107077 56085995
COVID-19 76.23 16.42 19 98976 75039 56118033
Gastrointestinal haemorrhage 75.66 16.42 20 98975 75931 56117141
Migraine 75.56 16.42 29 98966 86768 56106304
Interstitial lung disease 74.76 16.42 7 98988 57056 56136016
Hyperhidrosis 74.64 16.42 36 98959 94052 56099020
Renal impairment 73.60 16.42 25 98970 80688 56112384
Tremor 73.33 16.42 63 98932 121026 56072046
Hypoaesthesia 72.66 16.42 85 98910 141406 56051666
Depression 71.15 16.42 130 98865 179987 56013085
Blood glucose increased 70.78 16.42 22 98973 75129 56117943
Erythema 70.52 16.42 103 98892 155836 56037236
Facet joint syndrome 69.97 16.42 72 98923 6645 56186427
Intentional product misuse 69.49 16.42 224 98771 51280 56141792
Atrial fibrillation 69.24 16.42 54 98941 108843 56084229
Dyspnoea 68.94 16.42 1441 97554 591136 55601936
Leukopenia 68.20 16.42 20 98975 70920 56122152
Oropharyngeal pain 68.09 16.42 31 98964 83757 56109315
Neck pain 67.74 16.42 13 98982 61542 56131530
Abdominal pain 67.05 16.42 232 98763 258573 55934499
Maternal exposure during pregnancy 66.74 16.42 565 98430 188988 56004084
Deep vein thrombosis postoperative 66.72 16.42 56 98939 3985 56189087
Productive cough 66.02 16.42 10 98985 56222 56136850
Diabetes mellitus 65.17 16.42 8 98987 52727 56140345
Fluid retention 64.92 16.42 9 98986 54069 56139003
Heart rate increased 64.33 16.42 33 98962 83240 56109832
Visual impairment 64.24 16.42 25 98970 74177 56118895
Chest discomfort 64.15 16.42 48 98947 98809 56094263
Vision blurred 63.88 16.42 33 98962 82910 56110162
Hypotension 63.26 16.42 227 98768 250281 55942791
Exposure to toxic agent 62.87 16.42 52 98943 3626 56189446
Palpitations 62.64 16.42 50 98945 99622 56093450
Wrong technique in product usage process 62.52 16.42 13 98982 58155 56134917
Incorrect dose administered 62.48 16.42 9 98986 52538 56140534
Injection site reaction 61.31 16.42 10 98985 53237 56139835
Anxiety 59.41 16.42 160 98835 193012 56000060
Drug interaction 59.19 16.42 181 98814 209574 55983498
Cardiac disorder 59.13 16.42 6 98989 45881 56147191
Abdominal distension 58.15 16.42 32 98963 77594 56115478
Asthma 57.62 16.42 68 98927 112702 56080370
Herpes zoster 57.26 16.42 31 98964 75858 56117214
Chest pain 57.02 16.42 159 98836 189638 56003434
Chronic obstructive pulmonary disease 55.53 16.42 16 98979 57399 56135673
Muscular weakness 55.52 16.42 61 98934 104391 56088681
Peripheral venous disease 55.32 16.42 78 98917 10001 56183071
Multiple sclerosis relapse 55.03 16.42 7 98988 44896 56148176
Therapeutic response decreased 54.26 16.42 13 98982 52745 56140327
Influenza like illness 53.70 16.42 20 98975 60968 56132104
Hyperkalaemia 53.38 16.42 12 98983 50853 56142219
Blood pressure fluctuation 52.73 16.42 5 98990 40355 56152717
Oedema peripheral 52.53 16.42 142 98853 171112 56021960
Red blood cell sedimentation rate increased 52.22 16.42 3 98992 36620 56156452
No adverse event 51.81 16.42 3 98992 36371 56156701
Thrombosis 51.47 16.42 20 98975 59407 56133665
Dyspepsia 51.05 16.42 43 98952 83428 56109644
Stress 50.74 16.42 20 98975 58890 56134182
Blood creatinine increased 50.67 16.42 40 98955 80151 56112921
Cardiac failure 50.56 16.42 42 98953 82051 56111021
Deep vein thrombosis 50.43 16.42 37 98958 76940 56116132
Malignant neoplasm progression 50.01 16.42 34 98961 73553 56119519
Postmortem blood drug level abnormal 49.75 16.42 20 98975 339 56192733
Angioedema 49.52 16.42 7 98988 41446 56151626
Sepsis 49.15 16.42 108 98887 139732 56053340
Blood alcohol increased 49.09 16.42 23 98972 573 56192499
Cystitis 48.67 16.42 13 98982 49025 56144047
Cataract 48.25 16.42 15 98980 51232 56141840
Abdominal pain upper 47.97 16.42 502 98493 177811 56015261
Dysphagia 47.96 16.42 44 98951 81903 56111169
Plasma cell myeloma 46.99 16.42 12 98983 46634 56146438
C-reactive protein increased 46.34 16.42 42 98953 78642 56114430
Injection site swelling 46.29 16.42 10 98985 43568 56149504
Bradycardia 46.13 16.42 31 98964 67473 56125599
Osteoporosis 45.95 16.42 17 98978 52035 56141037
Respiratory failure 44.73 16.42 61 98934 95001 56098071
Abortion spontaneous 44.57 16.42 11 98984 43742 56149330
Haematochezia 44.52 16.42 11 98984 43707 56149365
Pleural effusion 44.25 16.42 51 98944 85429 56107643
Nasal congestion 44.04 16.42 22 98973 56348 56136724
Chronic kidney disease 43.97 16.42 10 98985 42046 56151026
Injection site pruritus 43.78 16.42 10 98985 41921 56151151
Cognitive disorder 43.45 16.42 16 98979 49117 56143955
Oxygen saturation decreased 43.33 16.42 45 98950 79022 56114050
Intentional product use issue 43.19 16.42 312 98683 99421 56093651
Cellulitis 42.97 16.42 41 98954 74908 56118164
Throat irritation 42.83 16.42 4 98991 32679 56160393
Burning sensation 42.82 16.42 16 98979 48680 56144392
Muscle spasms 42.05 16.42 114 98881 137257 56055815
Vertigo 41.59 16.42 22 98973 54550 56138522
Septic shock 41.48 16.42 28 98967 60807 56132265
Pancreatitis 41.02 16.42 14 98981 45066 56148006
Substance abuse 40.93 16.42 45 98950 4480 56188592
Fungal infection 40.78 16.42 5 98990 32988 56160084
Urticaria thermal 40.53 16.42 16 98979 258 56192814
Dyspnoea exertional 40.30 16.42 23 98972 54666 56138406
Skin exfoliation 40.16 16.42 8 98987 36892 56156180
Neutrophil count decreased 39.60 16.42 19 98976 49803 56143269
Alcoholism 39.37 16.42 32 98963 2177 56190895
Breast cancer 38.24 16.42 19 98976 48814 56144258
Femur fracture 37.91 16.42 11 98984 39284 56153788
Rhinorrhoea 37.90 16.42 27 98968 57010 56136062
International normalised ratio increased 37.85 16.42 15 98980 44026 56149046
Renal disorder 37.81 16.42 4 98991 29601 56163471
Disease progression 37.13 16.42 81 98914 105092 56087980
Bone pain 37.13 16.42 21 98974 50164 56142908
Haemorrhage 37.08 16.42 27 98968 56370 56136702
Gastric disorder 36.57 16.42 7 98988 33203 56159869
Product quality issue 36.44 16.42 6 98989 31730 56161342
Haematocrit decreased 36.10 16.42 10 98985 36819 56156253
Exposure during pregnancy 35.41 16.42 122 98873 136220 56056852
Full blood count abnormal 35.32 16.42 3 98992 26459 56166613
Unevaluable event 35.21 16.42 20 98975 47667 56145405
Intestinal obstruction 35.16 16.42 4 98991 27967 56165105
Hepatic function abnormal 34.60 16.42 9 98986 34549 56158523
Memory impairment 34.57 16.42 62 98933 86495 56106577
Orthostatic hypotension 34.50 16.42 8 98987 33191 56159881
Drug ineffective for unapproved indication 34.06 16.42 3 98992 25690 56167382
Victim of sexual abuse 33.81 16.42 18 98977 593 56192479
Flatulence 33.60 16.42 7 98988 31281 56161791
Mobility decreased 33.51 16.42 78 98917 98913 56094159
Basal cell carcinoma 33.28 16.42 3 98992 25218 56167854
Transient ischaemic attack 33.13 16.42 9 98986 33568 56159504
Autoimmune disorder 33.12 16.42 58 98937 8951 56184121
Swelling face 32.93 16.42 30 98965 56039 56137033
Haematoma 32.71 16.42 8 98987 32011 56161061
Multiple sclerosis 32.50 16.42 5 98990 27797 56165275
Red blood cell count decreased 32.25 16.42 12 98983 36605 56156467
Joint stiffness 32.24 16.42 11 98984 35414 56157658
Gastroenteritis 31.96 16.42 3 98992 24409 56168663
Blood pressure decreased 31.91 16.42 34 98961 59016 56134056
Vaginal haemorrhage 31.46 16.42 4 98991 25669 56167403
Rash pruritic 31.06 16.42 28 98967 52566 56140506
Illness 30.92 16.42 11 98984 34500 56158572
Coronary artery disease 30.87 16.42 8 98987 30788 56162284
Hospitalisation 30.61 16.42 53 98942 74947 56118125
Pulmonary arterial hypertension 30.46 16.42 5 98990 26498 56166574
Pregnancy 30.45 16.42 127 98868 32906 56160166
Dysphonia 30.39 16.42 18 98977 41929 56151143
Full blood count decreased 30.22 16.42 3 98992 23346 56169726
Poisoning deliberate 30.21 16.42 59 98936 9894 56183178
Feeling hot 30.18 16.42 18 98977 41769 56151303
Rash maculo-papular 29.97 16.42 7 98988 28900 56164172
Sleep apnoea syndrome 29.76 16.42 5 98990 26056 56167016
Hypothyroidism 29.70 16.42 15 98980 38181 56154891
Drug-induced liver injury 29.18 16.42 12 98983 34450 56158622
Febrile neutropenia 29.08 16.42 92 98903 105453 56087619
Blood pressure systolic increased 28.92 16.42 18 98977 40818 56152254
Cardiac arrest 28.61 16.42 254 98741 86060 56107012
Burkholderia test positive 28.35 16.42 12 98983 233 56192839
Dyskinesia 28.35 16.42 8 98987 29100 56163972
Cerebral haemorrhage 27.61 16.42 8 98987 28598 56164474
Therapy cessation 27.49 16.42 7 98988 27257 56165815
Abdominal pain lower 27.35 16.42 4 98991 23088 56169984
Liver function test abnormal 27.34 16.42 24 98971 45647 56147425
Drug eruption 27.18 16.42 6 98989 25757 56167315
Incorrect route of product administration 27.18 16.42 91 98904 21238 56171834
Nephrolithiasis 27.08 16.42 16 98979 37319 56155753
Oral herpes 27.03 16.42 4 98991 22886 56170186
Joint injury 27.02 16.42 6 98989 25648 56167424
Eye swelling 27.01 16.42 3 98992 21373 56171699
Liver injury 26.96 16.42 145 98850 41703 56151369
Urinary retention 26.82 16.42 8 98987 28066 56165006
Acne 26.63 16.42 3 98992 21133 56171939
Lymphocyte count decreased 26.62 16.42 8 98987 27931 56165141
Swollen tongue 26.60 16.42 10 98985 30314 56162758
Disease recurrence 26.33 16.42 5 98990 23855 56169217
Blood calcium decreased 26.19 16.42 5 98990 23764 56169308
Haematemesis 26.05 16.42 9 98986 28749 56164323
Toxic epidermal necrolysis 25.68 16.42 4 98991 22038 56171034
Jaundice 25.67 16.42 8 98987 27286 56165786
C-reactive protein 25.62 16.42 24 98971 1975 56191097
Clostridium difficile infection 25.53 16.42 8 98987 27190 56165882
Neoplasm malignant 25.32 16.42 8 98987 27047 56166025
Ear infection 24.77 16.42 12 98983 31283 56161789
Skin ulcer 24.71 16.42 19 98976 38589 56154483
Limb discomfort 24.69 16.42 8 98987 26614 56166458
Ascites 24.64 16.42 18 98977 37526 56155546
Injury 24.62 16.42 185 98810 59666 56133406
Haemoptysis 24.60 16.42 8 98987 26552 56166520
Musculoskeletal stiffness 24.51 16.42 167 98828 155840 56037232
Dry skin 24.49 16.42 28 98967 47081 56145991
Stevens-Johnson syndrome 24.48 16.42 5 98990 22658 56170414
Gastric ulcer 24.33 16.42 5 98990 22558 56170514
Cerebral infarction 24.24 16.42 5 98990 22500 56170572
Ulcer 24.21 16.42 5 98990 22480 56170592
White blood cell count increased 23.93 16.42 26 98969 44733 56148339
Pulmonary hypertension 23.90 16.42 17 98978 35927 56157145
Limb injury 23.88 16.42 5 98990 22265 56170807
Dysstasia 23.75 16.42 3 98992 19351 56173721
Melaena 23.71 16.42 10 98985 28280 56164792
Sinus disorder 23.63 16.42 4 98991 20730 56172342
Dry eye 23.60 16.42 17 98978 35699 56157373
Aphasia 23.56 16.42 12 98983 30403 56162669
Alanine aminotransferase increased 23.51 16.42 85 98910 93577 56099495
Surgery 23.45 16.42 14 98981 32472 56160600
Angina pectoris 23.27 16.42 10 98985 27966 56165106
Adverse event 23.25 16.42 172 98823 55204 56137868
Therapy interrupted 23.24 16.42 8 98987 25617 56167455
Chemical submission 23.13 16.42 10 98985 205 56192867
Diplopia 23.06 16.42 4 98991 20365 56172707
Lymphadenopathy 22.95 16.42 17 98978 35191 56157881
Hepatocellular injury 22.83 16.42 9 98986 26505 56166567
Viral infection 22.74 16.42 14 98981 31932 56161140
Road traffic accident 22.41 16.42 103 98892 27824 56165248
Flushing 22.33 16.42 57 98938 70043 56123029
Gastritis 22.31 16.42 17 98978 34685 56158387
Cholelithiasis 22.14 16.42 22 98973 39442 56153630
Device issue 22.10 16.42 5 98990 21101 56171971
Hip fracture 21.87 16.42 10 98985 26963 56166109
Rash erythematous 21.75 16.42 20 98975 37201 56155871
Tinnitus 21.61 16.42 13 98982 30029 56163043
Blood urea increased 21.58 16.42 8 98987 24465 56168607
Respiratory tract infection 21.54 16.42 19 98976 36052 56157020
Kidney infection 21.52 16.42 5 98990 20720 56172352
Product prescribing error 21.45 16.42 7 98988 23179 56169893
Burkholderia infection 21.38 16.42 4 98991 0 56193072
Protein C increased 21.36 16.42 8 98987 111 56192961
Drug resistance 21.24 16.42 5 98990 20537 56172535
Movement disorder 21.23 16.42 4 98991 19194 56173878
Hypoacusis 21.17 16.42 6 98989 21762 56171310
Pallor 21.12 16.42 8 98987 24141 56168931
Eye disorder 21.11 16.42 5 98990 20447 56172625
Localised infection 20.96 16.42 11 98984 27401 56165671
Hemiparesis 20.76 16.42 6 98989 21484 56171588
Diabetic ketoacidosis 20.73 16.42 4 98991 18867 56174205
Bone marrow failure 20.69 16.42 12 98983 28274 56164798
Mydriasis 20.56 16.42 54 98941 11017 56182055
Gallbladder disorder 20.53 16.42 3 98992 17331 56175741
Throat tightness 20.31 16.42 7 98988 22400 56170672
Dementia 20.25 16.42 3 98992 17155 56175917
Neoplasm progression 20.18 16.42 16 98979 32000 56161072
Blood potassium decreased 20.08 16.42 23 98972 38649 56154423
Aspartate aminotransferase increased 20.05 16.42 76 98919 82526 56110546
Angiokeratoma 20.04 16.42 8 98987 133 56192939
Blindness 20.03 16.42 4 98991 18417 56174655
Injection site rash 19.94 16.42 3 98992 16955 56176117
Speech disorder 19.80 16.42 22 98973 37471 56155601
Hyperglycaemia 19.63 16.42 23 98972 38258 56154814
Product use in unapproved indication 19.60 16.42 156 98839 140666 56052406
Burkholderia cepacia complex infection 19.56 16.42 8 98987 142 56192930
Body temperature decreased 19.55 16.42 4 98991 18104 56174968
Pollakiuria 19.44 16.42 10 98985 25192 56167880
Fracture 19.41 16.42 4 98991 18014 56175058
Pancreatitis acute 19.33 16.42 10 98985 25114 56167958
Joint range of motion decreased 19.22 16.42 92 98903 25273 56167799
Foot deformity 19.06 16.42 9 98986 23816 56169256
Ejection fraction 18.99 16.42 19 98976 1696 56191376
Eye irritation 18.96 16.42 5 98990 19023 56174049
Mental disorder 18.76 16.42 9 98986 23595 56169477
Proteinuria 18.73 16.42 4 98991 17566 56175506
Blood sodium decreased 18.55 16.42 8 98987 22326 56170746
Prescribed overdose 18.46 16.42 83 98912 22213 56170859
Lung neoplasm malignant 18.46 16.42 4 98991 17392 56175680
Mouth ulceration 18.45 16.42 15 98980 29625 56163447
Drug use disorder 18.40 16.42 31 98964 4638 56188434
Palmar-plantar erythrodysaesthesia syndrome 18.39 16.42 7 98988 21058 56172014
Glaucoma 18.36 16.42 4 98991 17325 56175747
Multiple organ dysfunction syndrome 18.32 16.42 41 98954 52729 56140343
Neuropathy peripheral 18.29 16.42 106 98889 102787 56090285
Obstructive airways disorder 18.28 16.42 4 98991 17278 56175794
Hypoglycaemia 18.08 16.42 45 98950 55770 56137302
Upper gastrointestinal haemorrhage 17.94 16.42 4 98991 17050 56176022
Therapeutic response unexpected 17.92 16.42 4 98991 17040 56176032
Nervousness 17.67 16.42 15 98980 29000 56164072
Haematuria 17.63 16.42 13 98982 26974 56166098
Homicide 17.63 16.42 10 98985 374 56192698
Blood pressure diastolic decreased 17.58 16.42 6 98989 19317 56173755
Conjunctivitis 17.52 16.42 5 98990 18055 56175017
Asthenopia 17.35 16.42 20 98975 2097 56190975
Hot flush 17.31 16.42 35 98960 46691 56146381
Iron deficiency anaemia 17.31 16.42 5 98990 17914 56175158
Substance dependence 17.20 16.42 8 98987 196 56192876
Ankle fracture 16.95 16.42 4 98991 16399 56176673
Product contamination microbial 16.94 16.42 8 98987 203 56192869
Catheter site injury 16.88 16.42 7 98988 129 56192943
Musculoskeletal discomfort 16.82 16.42 4 98991 16314 56176758
Heavy menstrual bleeding 16.65 16.42 4 98991 16205 56176867
Colitis 16.64 16.42 30 98965 41781 56151291
Poisoning 16.62 16.42 55 98940 12758 56180314
Dysmetropsia 16.59 16.42 6 98989 75 56192997
Caesarean section 16.48 16.42 4 98991 16087 56176985
Pharyngitis 16.45 16.42 6 98989 18532 56174540

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 3898.46 14.05 1802 27827 85956 31581759
Completed suicide 3115.97 14.05 1568 28061 89946 31577769
Toxicity to various agents 2720.28 14.05 1822 27807 179665 31488050
Intentional overdose 666.28 14.05 438 29191 40951 31626764
Cardio-respiratory arrest 652.56 14.05 471 29158 51255 31616460
Alcohol abuse 520.98 14.05 186 29443 4378 31663337
Overdose 468.92 14.05 481 29148 84183 31583532
Alcohol interaction 464.90 14.05 151 29478 2638 31665077
Intentional product misuse 442.94 14.05 330 29299 37621 31630094
Suicide attempt 410.50 14.05 313 29316 36935 31630780
Suspected suicide 328.49 14.05 129 29500 3978 31663737
Alcohol poisoning 247.96 14.05 98 29531 3073 31664642
Substance abuse 239.12 14.05 122 29507 7036 31660679
Drug dependence 220.93 14.05 177 29452 22402 31645313
Alcohol use 157.63 14.05 71 29558 3096 31664619
Aggression 150.72 14.05 180 29449 37111 31630604
Drug ineffective 146.94 14.05 95 29534 395478 31272237
Respiratory depression 146.70 14.05 116 29513 14394 31653321
Coma 139.69 14.05 182 29447 40968 31626747
Respiratory arrest 139.13 14.05 146 29483 26111 31641604
Poisoning deliberate 138.37 14.05 86 29543 7258 31660457
Burkholderia test positive 137.10 14.05 47 29582 975 31666740
Asphyxia 130.77 14.05 76 29553 5675 31662040
Exposure to toxic agent 119.14 14.05 55 29574 2540 31665175
Cardiac arrest 106.42 14.05 248 29381 88814 31578901
Recalled product administered 103.98 14.05 32 29597 464 31667251
Blood alcohol increased 101.73 14.05 35 29594 734 31666981
Burkholderia infection 100.31 14.05 22 29607 69 31667646
Product contamination microbial 96.60 14.05 32 29597 595 31667120
Incorrect route of product administration 96.41 14.05 83 29546 11590 31656125
Intentional product use issue 85.35 14.05 160 29469 49187 31618528
Off label use 80.04 14.05 126 29503 347148 31320567
Anaphylactic reaction 72.52 14.05 112 29517 29441 31638274
Burkholderia cepacia complex infection 70.88 14.05 19 29610 162 31667553
Poisoning 66.43 14.05 64 29565 10327 31657388
Drug withdrawal syndrome 60.58 14.05 81 29548 18669 31649046
Suicidal ideation 60.40 14.05 116 29513 36290 31631425
Recalled product 59.49 14.05 19 29610 313 31667402
Alcohol withdrawal syndrome 59.22 14.05 28 29601 1365 31666350
Diarrhoea 58.84 14.05 154 29475 352255 31315460
Fatigue 57.09 14.05 145 29484 335061 31332654
Intentional self-injury 56.60 14.05 66 29563 13249 31654466
Miosis 55.19 14.05 53 29576 8517 31659198
Mydriasis 54.93 14.05 47 29582 6505 31661210
Substance use disorder 54.87 14.05 20 29609 499 31667216
Tachycardia 52.81 14.05 174 29455 76033 31591682
Drug use disorder 51.71 14.05 37 29592 3946 31663769
Dyspnoea 49.37 14.05 161 29468 343318 31324397
Pneumonia 45.57 14.05 161 29468 335151 31332564
Arthralgia 45.13 14.05 45 29584 151379 31516336
Amnesia 44.37 14.05 79 29550 23323 31644392
Alcohol intolerance 44.06 14.05 16 29613 395 31667320
General physical health deterioration 43.59 14.05 26 29603 113409 31554306
Road traffic accident 42.89 14.05 64 29565 16317 31651398
Alcoholism 42.81 14.05 31 29598 3368 31664347
Interstitial lung disease 42.79 14.05 4 29625 61399 31606316
Agitation 42.38 14.05 129 29500 54040 31613675
Disease progression 42.00 14.05 16 29613 90448 31577267
Accidental death 41.85 14.05 26 29603 2191 31665524
Drug screen positive 41.52 14.05 32 29597 3820 31663895
Anaemia 41.40 14.05 86 29543 213436 31454279
Ex-drug abuser 41.23 14.05 12 29617 142 31667573
Death 40.92 14.05 515 29114 360054 31307661
Rash 39.19 14.05 81 29548 201405 31466310
Depressed level of consciousness 39.12 14.05 101 29528 38500 31629215
Condition aggravated 39.09 14.05 58 29571 163951 31503764
Cough 37.99 14.05 42 29587 134772 31532943
Sputum culture positive 36.69 14.05 22 29607 1739 31665976
Malignant neoplasm progression 36.62 14.05 14 29615 78984 31588731
Sopor 35.93 14.05 49 29580 11503 31656212
Medication error 35.86 14.05 71 29558 22701 31645014
Oedema peripheral 35.85 14.05 30 29599 109809 31557906
Hepatic fibrosis 34.97 14.05 29 29600 3845 31663870
Pain in extremity 34.07 14.05 35 29594 116168 31551547
Pulmonary oedema 33.89 14.05 105 29524 44397 31623318
Joint swelling 33.47 14.05 5 29624 53426 31614289
Myocardial infarction 33.46 14.05 34 29595 113420 31554295
Product dose omission issue 33.05 14.05 30 29599 105556 31562159
Nausea 32.42 14.05 163 29466 307784 31359931
Acanthamoeba keratitis 31.60 14.05 9 29620 98 31667617
Osteonecrosis of jaw 31.56 14.05 57 29572 17014 31650701
Impaired driving ability 30.31 14.05 22 29607 2399 31665316
Respiratory tract infection bacterial 29.73 14.05 18 29611 1448 31666267
Physical assault 28.92 14.05 16 29613 1086 31666629
Foetal alcohol syndrome 28.90 14.05 9 29620 136 31667579
Drug abuser 28.85 14.05 26 29603 3854 31663861
Homicide 28.56 14.05 15 29614 917 31666798
Weight increased 27.87 14.05 22 29607 82925 31584790
Therapeutic product effect incomplete 27.57 14.05 4 29625 43692 31624023
Opiates positive 26.90 14.05 12 29617 511 31667204
Asthma 26.66 14.05 4 29625 42607 31625108
Chemical burn of skin 26.43 14.05 6 29623 23 31667692
Dysarthria 25.73 14.05 77 29552 31940 31635775
Dehydration 25.65 14.05 45 29584 119066 31548649
Loss of consciousness 25.55 14.05 141 29488 77214 31590501
Withdrawal syndrome 25.42 14.05 42 29587 11675 31656040
Pain 25.07 14.05 90 29539 186669 31481046
Suicidal behaviour 25.04 14.05 16 29613 1416 31666299
Weight decreased 25.00 14.05 72 29557 159880 31507835
Prostate cancer 24.78 14.05 3 29626 37598 31630117
Respiratory tract infection viral 24.53 14.05 18 29611 1996 31665719
Peripheral swelling 24.09 14.05 17 29612 67848 31599867
Decreased appetite 23.92 14.05 69 29560 153148 31514567
Haemoglobin decreased 23.87 14.05 43 29586 112632 31555083
Sensitisation 23.33 14.05 8 29621 166 31667549
Somnolence 23.30 14.05 166 29463 99279 31568436
Myocardial fibrosis 23.17 14.05 14 29615 1122 31666593
Culture positive 23.17 14.05 12 29617 713 31667002
Cardiac failure congestive 23.16 14.05 24 29605 79363 31588352
Haematochezia 22.72 14.05 5 29624 40459 31627256
White blood cell count decreased 22.71 14.05 29 29600 87369 31580346
Sensorimotor disorder 22.54 14.05 10 29619 420 31667295
Asthenia 22.46 14.05 121 29508 224634 31443081
Suspected transmission of an infectious agent via product 22.06 14.05 12 29617 788 31666927
Dextrocardia 21.99 14.05 7 29622 114 31667601
Pyrexia 21.65 14.05 181 29448 303659 31364056
Back pain 21.22 14.05 44 29585 109369 31558346
Gun shot wound 21.08 14.05 13 29616 1081 31666634
Renal impairment 21.07 14.05 30 29599 86319 31581396
Cardiac failure 20.83 14.05 30 29599 85923 31581792
Unresponsive to stimuli 20.68 14.05 62 29567 25738 31641977
Metabolic acidosis 20.30 14.05 82 29547 39495 31628220
Accidental poisoning 20.25 14.05 11 29618 720 31666995
Product use in unapproved indication 19.98 14.05 39 29590 99132 31568583
Capillary nail refill test abnormal 19.77 14.05 5 29624 33 31667682
Nasopharyngitis 19.74 14.05 18 29611 63227 31604488
Musculoskeletal stiffness 19.69 14.05 7 29622 41318 31626397
Renal failure 19.64 14.05 55 29574 123275 31544440
Substance-induced mood disorder 19.56 14.05 6 29623 86 31667629
Drug interaction 19.49 14.05 288 29341 208255 31459460
Delirium tremens 19.08 14.05 10 29619 609 31667106
Drug diversion 18.79 14.05 11 29618 832 31666883
Myalgia 18.69 14.05 27 29602 77231 31590484
Drug intolerance 18.51 14.05 13 29616 52020 31615695
Dizziness 18.38 14.05 110 29519 199037 31468678
Shock 17.76 14.05 54 29575 22591 31645124
Hypotension 17.73 14.05 279 29350 204339 31463376
Respiratory rate decreased 17.44 14.05 15 29614 2090 31665625
Blood glucose increased 17.22 14.05 19 29610 61064 31606651
Somnambulism 17.17 14.05 17 29612 2835 31664880
Alcoholic liver disease 17.10 14.05 9 29620 553 31667162
Deep vein thrombosis 17.00 14.05 19 29610 60717 31606998
Muscular weakness 16.70 14.05 22 29607 65426 31602289
Brain oedema 16.68 14.05 37 29592 12795 31654920
Sinus tachycardia 16.59 14.05 42 29587 15807 31651908
Respiratory acidosis 16.39 14.05 21 29608 4641 31663074
Pruritus 16.32 14.05 61 29568 125106 31542609
Cerebrovascular accident 16.23 14.05 31 29598 79453 31588262
Blood ethanol 16.15 14.05 5 29624 74 31667641
Abnormal behaviour 16.11 14.05 54 29575 23774 31643941
Accident 15.97 14.05 19 29610 3892 31663823
Haematuria 15.91 14.05 12 29617 46302 31621413
Constipation 15.80 14.05 61 29568 123930 31543785
Prescription drug used without a prescription 15.69 14.05 12 29617 1416 31666299
Alcoholic pancreatitis 15.52 14.05 6 29623 177 31667538
Chemical burn 15.49 14.05 6 29623 178 31667537
Chest discomfort 15.47 14.05 14 29615 49355 31618360
Blood ethanol increased 15.33 14.05 8 29621 483 31667232
Cytokine release syndrome 15.28 14.05 42 29587 16600 31651115
Psoriasis 14.93 14.05 13 29616 46706 31621009
Abdominal pain 14.88 14.05 78 29551 145874 31521841
Chemical poisoning 14.75 14.05 5 29624 100 31667615
Cluster headache 14.75 14.05 8 29621 522 31667193
Chest pain 14.61 14.05 58 29571 116899 31550816
Toxicologic test abnormal 14.49 14.05 8 29621 541 31667174
Psychiatric disorder prophylaxis 14.35 14.05 4 29625 40 31667675
Neutropenia 14.31 14.05 75 29554 140289 31527426
Mobility decreased 14.25 14.05 4 29625 27465 31640250

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5261.96 14.77 3482 94558 223653 70606751
Drug abuse 3742.55 14.77 2397 95643 144859 70685545
Toxicity to various agents 3353.11 14.77 3321 94719 378851 70451553
Muscle injury 1397.27 14.77 790 97250 37704 70792700
Folliculitis 1365.19 14.77 806 97234 41764 70788640
Irritable bowel syndrome 1332.16 14.77 846 97194 50004 70780400
Sleep disorder due to general medical condition, insomnia type 1231.47 14.77 709 97331 35023 70795381
Lower respiratory tract infection 1075.67 14.77 1027 97013 110886 70719518
Cardio-respiratory arrest 1036.67 14.77 960 97080 99717 70730687
Impaired healing 975.68 14.77 814 97226 73560 70756844
Helicobacter infection 929.08 14.77 702 97338 54954 70775450
Duodenal ulcer perforation 900.68 14.77 666 97374 50446 70779958
Blister 858.40 14.77 865 97175 99661 70730743
Intentional overdose 831.31 14.77 842 97198 97593 70732811
Stomatitis 737.46 14.77 898 97142 127613 70702791
Ill-defined disorder 711.15 14.77 596 97444 54145 70776259
Pericarditis 686.77 14.77 709 97331 83996 70746408
Anti-cyclic citrullinated peptide antibody positive 656.52 14.77 635 97405 69550 70760854
Gastrointestinal disorder 652.84 14.77 766 97274 104661 70725743
Pemphigus 624.90 14.77 668 97372 82368 70748036
Sinusitis 623.76 14.77 954 97086 168241 70662163
Alcohol interaction 613.72 14.77 234 97806 4419 70825985
Glossodynia 593.83 14.77 663 97377 85824 70744580
Hand deformity 581.86 14.77 656 97384 85826 70744578
Discomfort 577.58 14.77 720 97320 104716 70725688
Systemic lupus erythematosus 569.64 14.77 703 97337 101199 70729205
Wound 519.70 14.77 661 97379 98071 70732333
Suspected suicide 493.24 14.77 242 97798 8592 70821812
Therapeutic product effect decreased 481.82 14.77 774 97266 142244 70688160
Synovitis 470.80 14.77 725 97315 128503 70701901
Overdose 469.12 14.77 841 97199 168904 70661500
Peripheral swelling 443.78 14.77 997 97043 235566 70594838
Swelling 436.44 14.77 866 97174 187673 70642731
Hepatic enzyme increased 417.43 14.77 765 97275 156225 70674179
Alcohol abuse 403.70 14.77 178 97862 4929 70825475
Intentional product misuse 398.53 14.77 520 97520 79075 70751329
Arthropathy 393.61 14.77 727 97313 149330 70681074
Hypersensitivity 378.92 14.77 921 97119 228891 70601513
Joint swelling 362.59 14.77 962 97078 252249 70578155
Nasopharyngitis 361.50 14.77 886 97154 221320 70609084
Suicide attempt 339.70 14.77 481 97559 79029 70751375
Contraindicated product administered 337.76 14.77 640 97400 133972 70696432
Contusion 331.51 14.77 617 97423 127419 70702985
Confusional state 311.92 14.77 982 97058 283416 70546988
Pruritus 311.67 14.77 1117 96923 344443 70485961
Alcohol poisoning 306.33 14.77 140 97900 4225 70826179
Infection 303.79 14.77 803 97237 209982 70620422
Nausea 290.82 14.77 457 97583 851631 69978773
Weight increased 284.45 14.77 857 97183 241474 70588930
Alopecia 264.74 14.77 735 97305 197755 70632649
Muscle spasticity 246.49 14.77 210 97830 19479 70810925
Night sweats 241.60 14.77 300 97740 43384 70787020
Fall 239.77 14.77 160 97880 443936 70386468
Infusion related reaction 239.66 14.77 707 97333 196827 70633577
Abdominal discomfort 236.76 14.77 743 97297 213915 70616489
Pneumonia 227.50 14.77 295 97745 595937 70234467
Alcohol use 217.96 14.77 113 97927 4514 70825890
Respiratory arrest 216.69 14.77 317 97723 53616 70776788
Ear pain 209.07 14.77 223 97817 27376 70803028
Anaemia 207.60 14.77 153 97887 403270 70427134
Cough 201.54 14.77 99 97941 325278 70505126
Substance abuse 186.26 14.77 134 97906 9703 70820701
Pain in extremity 179.92 14.77 116 97924 327966 70502438
Off label use 178.93 14.77 486 97554 742574 70087830
Exposure to toxic agent 169.32 14.77 106 97934 6088 70824316
Product dose omission issue 168.58 14.77 46 97994 217422 70612982
Body temperature increased 159.80 14.77 234 97806 39600 70790804
Malaise 159.00 14.77 220 97820 432712 70397692
Drug intolerance 158.63 14.77 675 97365 225012 70605392
Dizziness 153.91 14.77 253 97787 463888 70366516
Dehydration 145.81 14.77 65 97975 226077 70604327
Maternal exposure during pregnancy 143.70 14.77 417 97623 114928 70715476
Poisoning deliberate 134.80 14.77 141 97899 16919 70813485
Drug dependence 133.72 14.77 208 97832 37113 70793291
Acute kidney injury 133.30 14.77 286 97754 474338 70356066
Weight decreased 132.77 14.77 140 97900 310348 70520056
Respiratory disorder 129.11 14.77 210 97830 38913 70791491
Blood alcohol increased 124.69 14.77 51 97989 1166 70829238
Therapeutic product effect incomplete 122.32 14.77 12 98028 119870 70710534
Rash 119.76 14.77 1153 96887 509409 70320995
Myocardial infarction 119.31 14.77 44 97996 171601 70658803
Incorrect route of product administration 117.09 14.77 163 97877 26329 70804075
Burkholderia test positive 116.94 14.77 40 98000 544 70829860
Interstitial lung disease 116.60 14.77 7 98033 104678 70725726
Maternal exposure timing unspecified 114.66 14.77 73 97967 4318 70826086
Haemoglobin decreased 114.49 14.77 71 97969 205088 70625316
Condition aggravated 114.04 14.77 265 97775 427370 70403034
Diarrhoea 108.86 14.77 637 97403 782704 70047700
Cardiac arrest 108.33 14.77 473 97567 159361 70671043
Burkholderia infection 108.27 14.77 25 98015 63 70830341
Constipation 106.57 14.77 115 97925 252323 70578081
Decreased appetite 103.84 14.77 163 97877 304617 70525787
Lip dry 103.75 14.77 95 97945 9690 70820714
Coma 102.99 14.77 320 97720 91524 70738880
Cardiac failure congestive 100.61 14.77 31 98009 135426 70694978
Product contamination microbial 99.90 14.77 40 98000 864 70829540
Injection site pain 96.68 14.77 22 98018 117597 70712807
Renal failure 95.42 14.77 73 97967 188997 70641407
White blood cell count decreased 94.75 14.77 59 97981 170082 70660322
Cerebrovascular accident 94.40 14.77 40 98000 143430 70686974
Recalled product administered 93.55 14.77 37 98003 773 70829631
Urinary tract infection 92.61 14.77 125 97915 248644 70581760
Myalgia 89.71 14.77 61 97979 167831 70662573
Blood pressure increased 86.27 14.77 80 97960 188437 70641967
Neutropenia 86.18 14.77 139 97901 257017 70573387
Facet joint syndrome 84.37 14.77 69 97971 6044 70824360
Renal impairment 84.26 14.77 47 97993 143890 70686514
Psoriasis 83.77 14.77 17 98023 98416 70731988
Asphyxia 82.64 14.77 86 97954 10256 70820148
Bronchitis 81.54 14.77 30 98010 117213 70713191
Pancytopenia 80.60 14.77 55 97985 151052 70679352
Aggression 80.47 14.77 195 97845 48251 70782153
Medication error 79.93 14.77 215 97825 56697 70773707
Gait disturbance 79.57 14.77 83 97957 185023 70645381
Intentional product use issue 79.44 14.77 353 97687 119789 70710615
Arthritis 77.25 14.77 20 98020 97960 70732444
Syncope 76.20 14.77 70 97970 165639 70664765
Chills 72.91 14.77 56 97984 144730 70685674
Inappropriate schedule of product administration 72.34 14.77 29 98011 107526 70722878
Pregnancy 72.22 14.77 123 97917 23658 70806746
Feeling abnormal 70.46 14.77 56 97984 142263 70688141
Headache 70.19 14.77 492 97548 579913 70250491
Productive cough 69.93 14.77 12 98028 78325 70752079
Loss of personal independence in daily activities 69.54 14.77 16 98024 84894 70745510
Malignant neoplasm progression 68.06 14.77 42 97998 121697 70708707
Deep vein thrombosis postoperative 67.97 14.77 49 97991 3558 70826846
Cardiac failure 67.95 14.77 59 97981 143482 70686922
Platelet count decreased 67.89 14.77 88 97952 178134 70652270
Thrombocytopenia 67.88 14.77 143 97897 238967 70591437
Urticaria 67.64 14.77 421 97619 162628 70667776
Rheumatoid arthritis 65.76 14.77 654 97386 291151 70539253
Blood glucose increased 65.70 14.77 30 98010 102952 70727452
Haematochezia 65.67 14.77 11 98029 73070 70757334
Blood pressure fluctuation 65.54 14.77 4 98036 59008 70771396
Injection site erythema 65.47 14.77 11 98029 72913 70757491
Substance use disorder 65.15 14.77 27 98013 639 70829765
Gastrointestinal haemorrhage 64.42 14.77 57 97983 137351 70693053
Hypertension 63.41 14.77 204 97836 295829 70534575
Respiratory depression 63.32 14.77 119 97921 24712 70805692
Influenza 62.50 14.77 40 98000 113660 70716744
Postmortem blood drug level abnormal 62.44 14.77 26 98014 623 70829781
Atrial fibrillation 61.40 14.77 100 97940 184248 70646156
Hyperkalaemia 60.67 14.77 36 98004 106555 70723849
Peripheral venous disease 60.03 14.77 74 97966 10613 70819791
Deep vein thrombosis 59.76 14.77 40 98000 111002 70719402
Muscular weakness 59.47 14.77 62 97978 138274 70692130
Hyponatraemia 58.98 14.77 81 97959 160006 70670398
Leukopenia 57.87 14.77 38 98002 106522 70723882
Neck pain 57.79 14.77 11 98029 66646 70763758
Poisoning 57.17 14.77 108 97932 22514 70807890
Oedema peripheral 57.03 14.77 146 97894 227945 70602459
Drug use disorder 56.72 14.77 63 97977 8088 70822316
Balance disorder 56.34 14.77 27 98013 90101 70740303
Abdominal pain 55.82 14.77 263 97777 341864 70488540
Vision blurred 55.60 14.77 31 98009 94953 70735451
Chronic obstructive pulmonary disease 55.46 14.77 19 98021 77622 70752782
Blood creatinine increased 55.08 14.77 70 97970 142931 70687473
Mydriasis 55.04 14.77 88 97952 16065 70814339
Migraine 54.59 14.77 16 98024 72222 70758182
Oropharyngeal pain 54.15 14.77 33 98007 96277 70734127
Diabetes mellitus 54.11 14.77 16 98024 71808 70758596
Abdominal distension 53.31 14.77 40 98000 104629 70725775
Cardiac disorder 53.25 14.77 9 98031 59406 70770998
Chest discomfort 53.18 14.77 56 97984 124325 70706079
Acute myocardial infarction 51.78 14.77 18 98022 72869 70757535
Liver injury 51.67 14.77 149 97891 40886 70789518
Alcoholism 50.76 14.77 45 97995 4400 70826004
Pulmonary embolism 50.55 14.77 86 97954 155781 70674623
Upper respiratory tract infection 49.17 14.77 24 98016 79250 70751154
Gastrooesophageal reflux disease 48.51 14.77 33 98007 90806 70739598
Dyspepsia 48.05 14.77 32 98008 89045 70741359
Asthma 47.70 14.77 58 97982 120735 70709669
Disease progression 47.62 14.77 90 97950 156582 70673822
Plasma cell myeloma 47.19 14.77 21 98019 73180 70757224
Recalled product 47.10 14.77 24 98016 924 70829480
Herpes zoster 46.82 14.77 30 98010 85205 70745199
Angioedema 46.38 14.77 17 98023 66593 70763811
Therapeutic response decreased 45.94 14.77 12 98028 58441 70771963
Sepsis 45.36 14.77 179 97861 244366 70586038
Pleural effusion 45.24 14.77 71 97969 132793 70697611
Influenza like illness 44.94 14.77 17 98023 65314 70765090
Osteoporosis 44.75 14.77 7 98033 48900 70781504
Chest pain 44.66 14.77 187 97853 251073 70579331
Haematuria 44.65 14.77 16 98024 63557 70766847
Erythema 44.48 14.77 135 97905 199428 70630976
Urticaria thermal 44.22 14.77 16 98024 259 70830145
Thrombosis 43.57 14.77 25 98015 75380 70755024
Haemoptysis 43.53 14.77 9 98031 51443 70778961
Fluid retention 42.76 14.77 17 98023 63368 70767036
Hypoaesthesia 42.73 14.77 93 97947 153646 70676758
Dysphagia 42.66 14.77 56 97984 112778 70717626
Road traffic accident 41.81 14.77 124 97916 34558 70795846
Chronic kidney disease 41.81 14.77 16 98024 61041 70769363
Alcohol withdrawal syndrome 41.70 14.77 28 98012 1813 70828591
Injection site reaction 41.61 14.77 9 98031 49843 70780561
Accidental death 41.54 14.77 38 98002 3870 70826534
Stress 41.51 14.77 21 98019 67945 70762459
Dyspnoea exertional 41.20 14.77 29 98011 78401 70752003
COVID-19 40.48 14.77 52 97988 105705 70724699
Skin exfoliation 40.13 14.77 9 98031 48617 70781787
International normalised ratio increased 39.65 14.77 32 98008 80694 70749710
C-reactive protein increased 39.62 14.77 57 97983 110460 70719944
Intestinal obstruction 39.29 14.77 4 98036 38821 70791583
Nasal congestion 39.06 14.77 21 98019 65651 70764753
Pyrexia 38.96 14.77 1106 96934 605846 70224558
Agranulocytosis 38.66 14.77 5 98035 40293 70790111
Drug hypersensitivity 38.65 14.77 209 97831 262250 70568154
Miosis 37.73 14.77 69 97971 14032 70816372
Injection site swelling 37.67 14.77 7 98033 43150 70787254
Incorrect dose administered 37.31 14.77 23 98017 66696 70763708
Rheumatoid factor positive 37.25 14.77 149 97891 48251 70782153
Palpitations 36.93 14.77 60 97980 110693 70719711
Visual impairment 36.75 14.77 34 98006 80216 70750188
Neutrophil count decreased 36.41 14.77 37 98003 83519 70746885
Drug ineffective 36.29 14.77 1006 97034 938746 69891658
Autoimmune disorder 36.19 14.77 52 97988 8644 70821760
Hepatic function abnormal 35.90 14.77 25 98015 67971 70762433
Drug eruption 35.36 14.77 6 98034 39490 70790914
Drug reaction with eosinophilia and systemic symptoms 35.32 14.77 18 98022 57995 70772409
Intentional self-injury 35.19 14.77 110 97930 31540 70798864
Rash maculo-papular 35.02 14.77 13 98027 50532 70779872
Depression 34.78 14.77 149 97891 198825 70631579
Product use in unapproved indication 34.68 14.77 158 97882 207320 70623084
Homicide 34.46 14.77 21 98019 1149 70829255
Angina pectoris 34.28 14.77 12 98028 48371 70782033
Cataract 34.27 14.77 17 98023 55628 70774776
Wrong technique in product usage process 34.03 14.77 27 98013 68671 70761733
Heart rate increased 34.01 14.77 59 97981 106089 70724315
Diverticulitis 33.89 14.77 8 98032 41726 70788678
Coronary artery disease 33.21 14.77 23 98017 62713 70767691
Orthostatic hypotension 33.11 14.77 15 98025 51728 70778676
Haematocrit decreased 33.05 14.77 19 98021 57239 70773165
Full blood count abnormal 33.00 14.77 4 98036 33874 70796530
Rhinorrhoea 32.98 14.77 26 98014 66345 70764059
Dysphonia 32.88 14.77 14 98026 50086 70780318
Septic shock 32.79 14.77 66 97974 112192 70718212
Basal cell carcinoma 32.77 14.77 4 98036 33694 70796710
Pain 31.94 14.77 1114 96926 627702 70202702
Burkholderia cepacia complex infection 31.79 14.77 13 98027 297 70830107
Cellulitis 31.68 14.77 55 97985 98873 70731531
Drug resistance 31.66 14.77 7 98033 38183 70792221
Blood pressure systolic increased 31.65 14.77 20 98020 57239 70773165
Multiple sclerosis relapse 31.65 14.77 10 98030 43007 70787397
Transient ischaemic attack 31.52 14.77 12 98028 45932 70784472
Toxic epidermal necrolysis 31.31 14.77 8 98032 39549 70790855
Acanthamoeba keratitis 31.24 14.77 10 98030 109 70830295
Febrile neutropenia 31.01 14.77 161 97879 204157 70626247
Opiates positive 30.62 14.77 18 98022 922 70829482
Red blood cell count decreased 30.55 14.77 17 98023 52144 70778260
Vertigo 30.55 14.77 25 98015 62618 70767786
General physical health deterioration 30.47 14.77 196 97844 235835 70594569
Insomnia 30.45 14.77 446 97594 217360 70613044
Cholestasis 30.44 14.77 14 98026 47858 70782546
Heart rate irregular 30.27 14.77 3 98037 29740 70800664
Throat irritation 30.23 14.77 6 98034 35298 70795106
Blood urea increased 29.86 14.77 13 98027 45896 70784508
Mobility decreased 29.70 14.77 61 97979 102938 70727466
Cytomegalovirus infection 29.68 14.77 9 98031 39749 70790655
Cystitis 29.43 14.77 14 98026 46927 70783477
Melaena 29.39 14.77 21 98019 56334 70774070
Ascites 29.33 14.77 30 98010 67517 70762887
Femur fracture 29.20 14.77 7 98033 36125 70794279
Respiratory failure 29.09 14.77 127 97913 168608 70661796
Injection site pruritus 29.05 14.77 9 98031 39201 70791203
Hyperhidrosis 28.61 14.77 90 97950 131496 70698908
Hepatocellular injury 28.51 14.77 14 98026 46077 70784327
Palmar-plantar erythrodysaesthesia syndrome 28.43 14.77 4 98036 30243 70800161
Anxiety 28.41 14.77 183 97857 220147 70610257
Cerebral infarction 28.26 14.77 12 98028 42997 70787407
Hypothyroidism 28.15 14.77 14 98026 45741 70784663
Haematoma 28.04 14.77 16 98024 48402 70782002
Gastric disorder 27.84 14.77 6 98034 33316 70797088
Limb discomfort 27.75 14.77 4 98036 29701 70800703
C-reactive protein 27.74 14.77 23 98017 2053 70828351
Renal disorder 27.67 14.77 9 98031 38000 70792404
Sleep disorder 27.45 14.77 178 97862 69694 70760710
Haemorrhage 27.39 14.77 46 97994 83769 70746635
Bone marrow failure 27.25 14.77 17 98023 48993 70781411
Bradycardia 27.25 14.77 85 97955 124530 70705874
Disease recurrence 27.20 14.77 9 98031 37594 70792810
Jaundice 27.02 14.77 18 98022 50090 70780314
Product prescribing error 27.02 14.77 10 98030 38942 70791462
Nephrolithiasis 26.89 14.77 16 98024 47307 70783097
Injury 26.73 14.77 168 97872 65077 70765327
Victim of sexual abuse 26.52 14.77 13 98027 460 70829944
Blood ethanol 26.07 14.77 9 98031 126 70830278
Pneumocystis jirovecii pneumonia 26.00 14.77 5 98035 30077 70800327
Abdominal pain lower 25.90 14.77 4 98036 28212 70802192
Diplopia 25.81 14.77 4 98036 28143 70802261
Lymphocyte count decreased 25.78 14.77 14 98026 43525 70786879
Oxygen saturation decreased 25.76 14.77 79 97961 116350 70714054
Cerebral haemorrhage 25.65 14.77 22 98018 53842 70776562
Gastroenteritis 25.31 14.77 6 98034 31207 70799197
Swelling face 25.28 14.77 30 98010 63134 70767270
Blood ethanol increased 25.19 14.77 14 98026 644 70829760
Ulcer 25.18 14.77 3 98037 25751 70804653
Sleep apnoea syndrome 25.17 14.77 7 98033 32706 70797698
Pneumonitis 25.15 14.77 23 98017 54574 70775830
Proteinuria 25.14 14.77 5 98035 29369 70801035
Bone pain 25.14 14.77 20 98020 50802 70779602
Dysstasia 24.46 14.77 3 98037 25176 70805228
Drug screen positive 24.42 14.77 35 98005 5805 70824599
Drug abuser 24.31 14.77 35 98005 5829 70824575
Body temperature decreased 24.29 14.77 5 98035 28667 70801737
Acne 24.22 14.77 3 98037 24986 70805418
Anaphylactic reaction 24.16 14.77 182 97858 74792 70755612
Neuropathy peripheral 24.07 14.77 92 97948 126804 70703600
Corneal defect 23.99 14.77 5 98035 6 70830398
Diabetic ketoacidosis 23.77 14.77 7 98033 31505 70798899
Chemical submission 23.73 14.77 10 98030 247 70830157
Asthenia 23.70 14.77 468 97572 457198 70373206
Pulmonary arterial hypertension 23.53 14.77 8 98032 32847 70797557
Amphetamines positive 23.51 14.77 10 98030 253 70830151
Burning sensation 23.50 14.77 23 98017 52847 70777557
Neoplasm progression 23.39 14.77 17 98023 45211 70785193
Urinary retention 23.17 14.77 23 98017 52497 70777907
Colitis ulcerative 23.04 14.77 9 98031 33914 70796490
Flatulence 23.01 14.77 12 98028 38169 70792235
Colitis 22.78 14.77 33 98007 63781 70766623
Electrocardiogram QRS complex prolonged 22.56 14.77 45 97995 9761 70820643
Ejection fraction 22.47 14.77 19 98021 1743 70828661
Postmortem blood drug level 22.44 14.77 10 98030 284 70830120
Gastric ulcer 22.32 14.77 8 98032 31782 70798622
Agitation 22.31 14.77 212 97828 93163 70737241
Joint injury 22.19 14.77 5 98035 26927 70803477
Pulmonary hypertension 22.16 14.77 19 98021 46517 70783887
Death 22.09 14.77 888 97152 509173 70321231
Rash pruritic 22.07 14.77 33 98007 62958 70767446
Alcohol intolerance 22.07 14.77 11 98029 404 70830000
Faeces discoloured 22.05 14.77 5 98035 26804 70803600
Adverse event 21.93 14.77 130 97910 49331 70781073
Myelodysplastic syndrome 21.77 14.77 7 98033 29778 70800626
Hypocalcaemia 21.75 14.77 18 98022 44841 70785563
Rectal haemorrhage 21.63 14.77 36 98004 65795 70764609
Lung neoplasm malignant 21.62 14.77 4 98036 24738 70805666
Joint range of motion decreased 21.55 14.77 82 97958 25944 70804460
Cognitive disorder 21.29 14.77 32 98008 60924 70769480
Joint stiffness 21.28 14.77 11 98029 35165 70795239
Subdural haematoma 21.22 14.77 7 98033 29291 70801113
Metastases to liver 20.94 14.77 5 98035 25873 70804531
Dementia 20.92 14.77 3 98037 22362 70808042
Movement disorder 20.87 14.77 4 98036 24125 70806279
Pancreatitis 20.84 14.77 34 98006 62634 70767770
Fungal infection 20.83 14.77 13 98027 37454 70792950
Lymphadenopathy 20.81 14.77 22 98018 48769 70781635
Limb injury 20.79 14.77 5 98035 25747 70804657
Asthenopia 20.75 14.77 20 98020 2176 70828228
Illness 20.68 14.77 9 98031 31782 70798622
Respiratory tract infection bacterial 20.66 14.77 18 98022 1719 70828685
Full blood count decreased 20.62 14.77 4 98036 23914 70806490
Neoplasm malignant 20.62 14.77 7 98033 28767 70801637
Feeling cold 20.57 14.77 5 98035 25565 70804839
Toxicologic test abnormal 20.49 14.77 16 98024 1311 70829093
Myelosuppression 20.47 14.77 8 98032 30137 70800267
Viral infection 20.42 14.77 14 98026 38377 70792027
Pulmonary fibrosis 20.36 14.77 11 98029 34299 70796105
Sputum culture positive 20.10 14.77 24 98016 3330 70827074
Substance dependence 20.05 14.77 11 98029 493 70829911
Protein C increased 19.90 14.77 7 98033 104 70830300
Therapy cessation 19.69 14.77 11 98029 33665 70796739
Arthralgia 19.67 14.77 867 97173 502523 70327881
Iron deficiency anaemia 19.59 14.77 4 98036 23068 70807336
Obstructive airways disorder 19.33 14.77 6 98034 26107 70804297
Skin ulcer 19.12 14.77 23 98017 48122 70782282
Hip arthroplasty 18.97 14.77 83 97957 27957 70802447
Blood pressure decreased 18.91 14.77 64 97976 91451 70738953
Device issue 18.75 14.77 5 98035 24020 70806384
Cystitis noninfective 18.72 14.77 15 98025 1276 70829128
Tremor 18.68 14.77 132 97908 155492 70674912
Injection site haemorrhage 18.66 14.77 6 98034 25521 70804883
White blood cell count increased 18.57 14.77 43 97997 69530 70760874
Suspected transmission of an infectious agent via product 18.50 14.77 14 98026 1095 70829309
Multiple organ dysfunction syndrome 18.50 14.77 82 97958 108433 70721971
Vaginal haemorrhage 18.42 14.77 3 98037 20349 70810055
Muscle spasms 18.33 14.77 131 97909 153915 70676489
Angiokeratoma 18.29 14.77 8 98032 217 70830187
Pulmonary oedema 18.28 14.77 184 97856 82094 70748310
Dry eye 18.22 14.77 11 98029 32271 70798133
Upper gastrointestinal haemorrhage 18.22 14.77 15 98025 37462 70792942
Breast cancer 18.16 14.77 12 98028 33537 70796867
Palmar erythema 18.13 14.77 17 98023 1786 70828618
Catheter site injury 18.07 14.77 7 98033 138 70830266
Underdose 18.06 14.77 9 98031 29374 70801030
Oral candidiasis 18 14.77 6 98034 24946 70805458
Swollen tongue 17.80 14.77 15 98025 37031 70793373
Localised infection 17.76 14.77 12 98028 33146 70797258
Myocardial fibrosis 17.58 14.77 16 98024 1619 70828785
Feeling hot 17.54 14.77 25 98015 48645 70781759
Blood calcium decreased 17.48 14.77 9 98031 28837 70801567
Eosinophilia 17.40 14.77 18 98022 40301 70790103
Dysmetropsia 17.32 14.77 6 98034 85 70830319
Alanine aminotransferase increased 17.26 14.77 126 97914 147354 70683050
Blood pressure diastolic decreased 17.25 14.77 7 98033 25773 70804631
Abdominal pain upper 17.21 14.77 369 97671 193233 70637171
Drug interaction 17.13 14.77 399 97641 381042 70449362
Gastritis 16.98 14.77 22 98018 44569 70785835
Blood sodium decreased 16.90 14.77 11 98029 30987 70799417
Drug ineffective for unapproved indication 16.86 14.77 17 98023 38521 70791883
Eye disorder 16.85 14.77 4 98036 20781 70809623
Delirium tremens 16.57 14.77 11 98029 699 70829705
Eye swelling 16.48 14.77 6 98034 23608 70806796
Abortion spontaneous 16.44 14.77 8 98032 26471 70803933
Cholelithiasis 16.39 14.77 25 98015 47315 70783089
Chromaturia 16.38 14.77 6 98034 23522 70806882
Hypophagia 16.36 14.77 20 98020 41550 70788854
Muscle rigidity 16.33 14.77 3 98037 18647 70811757
Capillary nail refill test abnormal 16.28 14.77 5 98035 47 70830357
Platelet count increased 16.24 14.77 4 98036 20269 70810135
Physical assault 16.22 14.77 15 98025 1549 70828855
Hospitalisation 16.22 14.77 59 97981 82509 70747895
Therapy interrupted 16.17 14.77 7 98033 24795 70805609
Cytokine release syndrome 16.16 14.77 76 97964 26391 70804013
Hyperthyroidism 16.02 14.77 4 98036 20087 70810317
Induced abortion failed 16 14.77 7 98033 190 70830214
Musculoskeletal stiffness 16.00 14.77 129 97911 147631 70682773
Hepatic fibrosis 15.93 14.77 30 98010 6237 70824167
Neuroleptic malignant syndrome 15.93 14.77 8 98032 25999 70804405
Blood potassium increased 15.87 14.77 9 98031 27317 70803087
Accidental poisoning 15.85 14.77 15 98025 1595 70828809
Polyneuropathy 15.71 14.77 5 98035 21410 70808994
Obesity 15.71 14.77 76 97964 26695 70803709
Lower limb fracture 15.70 14.77 55 97985 16717 70813687
Stevens-Johnson syndrome 15.53 14.77 16 98024 35891 70794513
Substance-induced mood disorder 15.46 14.77 6 98034 119 70830285
Dysgeusia 15.41 14.77 28 98012 49474 70780930
Catheter site rash 15.41 14.77 12 98028 979 70829425
Ischaemic stroke 15.40 14.77 12 98028 30808 70799596
Oesophagitis 15.40 14.77 6 98034 22646 70807758
Conjunctivitis 15.38 14.77 6 98034 22630 70807774
Aspergillus infection 15.38 14.77 3 98037 17865 70812539
Kidney infection 15.27 14.77 4 98036 19451 70810953
Anti-cyclic citrullinated peptide antibody 15.21 14.77 21 98019 3364 70827040
Hyperglycaemia 14.93 14.77 43 97997 64629 70765775
Flank pain 14.93 14.77 3 98037 17499 70812905
Extradural abscess 14.92 14.77 13 98027 1242 70829162
Haematemesis 14.84 14.77 28 98012 48769 70781635
Biliary sepsis 14.83 14.77 14 98026 1484 70828920
Pallor 14.81 14.77 21 98019 40953 70789451

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AB03 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Antiinfectives and antiseptics for local oral treatment
ATC B05CA02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Antiinfectives
ATC D08AC02 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Biguanides and amidines
ATC D08AC52 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Biguanides and amidines
ATC D09AA12 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA05 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
ATC S01AX09 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Other antiinfectives
ATC S02AA09 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA04 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
FDA PE N0000008478 Decreased Cell Wall Integrity
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003879 Dermatologic Agents
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:35441 antiinfective agents
MeSH PA D003358 Cosmetics
MeSH PA D004202 Disinfectants
MeSH PA D009067 Mouthwashes

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Gingivitis indication 66383009 DOID:3087
Mouth Infection Prevention indication
Denture stomatitis off-label use 69254008 DOID:11875
Aphthous ulcer of mouth off-label use 426965005 DOID:9663
Dental Plaque Prevention off-label use
Periodontitis contraindication 41565005 DOID:824
Open wound contraindication 125643001
Front Tooth Fillings contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Topical antiseptic for surface wounds Indication
Cattle Metritis Indication
Cattle Vaginitis Indication
Dogs Topical antiseptic for surface wounds Indication
Horses Topical antiseptic for surface wounds Indication
Horses Metritis Indication
Horses Vaginitis Indication

🐶 Veterinary products

ProductApplicantIngredients
Nolvasan Antiseptic Ointment Zoetis Inc. 1
Nolvasan Cap-Tabs Zoetis Inc. 1
Nolvasan Suspension Zoetis Inc. 1
Privasan Antiseptic Ointment First Priority Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.17 Basic
pKa2 10.57 Basic
pKa3 3.32 Basic
pKa4 2.72 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
2% CHLORHEXIDINE GLUCONATE SAGE PRODS N021669 April 25, 2005 OTC CLOTH TOPICAL 7595021 May 12, 2023 FOR THE PREPARATION OF SKIN PRIOR TO SURGERY; HELPS REDUCE BACTERIA THAT CAN POTENTIALLY CAUSE SKIN INFECTION
2% CHLORHEXIDINE GLUCONATE SAGE PRODS N021669 April 25, 2005 OTC CLOTH TOPICAL 7066916 Feb. 17, 2024 DISINFECTION OF PATIENT SKIN PRIOR TO AN INVASIVE PROCEDURE
2% CHLORHEXIDINE GLUCONATE SAGE PRODS N021669 April 25, 2005 OTC CLOTH TOPICAL 7717889 Feb. 27, 2025 FOR THE PREPARATION OF SKIN PRIOR TO SURGERY; HELPS REDUCE BACTERIA THAT CAN POTENTIALLY CAUSE SKIN INFECTION
2%;70% (10.5ML) CHLORAPREP WITH TINT BECTON DICKINSON CO N020832 April 3, 2006 OTC SPONGE TOPICAL 7422388 April 25, 2027 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (26ML) CHLORAPREP WITH TINT BECTON DICKINSON CO N020832 May 3, 2005 OTC SPONGE TOPICAL 7422388 April 25, 2027 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (3ML) CHLORAPREP WITH TINT BECTON DICKINSON CO N020832 Oct. 10, 2006 OTC SPONGE TOPICAL 7422388 April 25, 2027 USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2% CHLORHEXIDINE GLUCONATE SAGE PRODS N021669 April 25, 2005 OTC CLOTH TOPICAL 7935093 Oct. 2, 2027 FOR THE PREPARATION OF SKIN PRIOR TO SURGERY; HELPS REDUCE BACTERIA THAT CAN POTENTIALLY CAUSE SKIN INFECTION
2%;70% SOLUPREP 3M HEALTH CARE N208288 Aug. 8, 2018 OTC SOLUTION TOPICAL 8623935 July 26, 2029 FOR THE PREPARATION OF SKIN PRIOR TO SURGERY; HELPS REDUCE BACTERIA THAT CAN POTENTIALLY CAUSE SKIN INFECTION

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
72 kDa type IV collagenase Enzyme IC50 5.12 CHEMBL
Matrix metalloproteinase-9 Enzyme IC50 5.12 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 6.68 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 6.40 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 6.15 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 6.30 CHEMBL
Solute carrier family 22 member 3 Transporter IC50 6.39 CHEMBL
Synaptojanin-2 Enzyme IC50 5 CHEMBL
Trypanothione reductase Enzyme Ki 5.70 CHEMBL
CAAX prenyl protease 2 Enzyme AC50 5.24 CHEMBL

External reference:

IDSource
D00858 KEGG_DRUG
3697-42-5 SECONDARY_CAS_RN
18472-51-0 SECONDARY_CAS_RN
20791 RXNORM
4019393 VANDF
4019673 VANDF
C0008196 UMLSCUI
CHEBI:3614 CHEBI
CHEMBL790 ChEMBL_ID
CHEMBL1484251 ChEMBL_ID
CHEMBL4297088 ChEMBL_ID
CHEMBL1628 ChEMBL_ID
D002710 MESH_DESCRIPTOR_UI
DB00878 DRUGBANK_ID
C010882 MESH_SUPPLEMENTAL_RECORD_UI
500 INN_ID
R4KO0DY52L UNII
9552079 PUBCHEM_CID
4411 MMSL
6085 MMSL
003177 NDDF
003674 NDDF
003722 NDDF
003723 NDDF
108895000 SNOMEDCT_US
373568007 SNOMEDCT_US
96316004 SNOMEDCT_US
96317008 SNOMEDCT_US
96318003 SNOMEDCT_US
CHEMBL486819 ChEMBL_ID
56-95-1 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Chlorhexidine Gluconate 0.12% Oral Rinse HUMAN PRESCRIPTION DRUG LABEL 1 0116-0003 LIQUID 1.20 [iU] BUCCAL ANDA 18 sections
Chlorhexidine Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 0116-0101 LIQUID 0.12 mg ORAL ANDA 17 sections
Cardinal Health Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0113 SOLUTION 2 g TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0115 LIQUID 4 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0137 LIQUID 4 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0161 LIQUID 4 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0162 LIQUID 4 mg TOPICAL NDA 14 sections
Chlorhexidine Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 0116-0175 RINSE 1.20 mg ORAL ANDA 17 sections
BETASEPT HUMAN PRESCRIPTION DRUG LABEL 1 0116-0200 SOLUTION 0.04 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0228 LIQUID 4 mg TOPICAL NDA 15 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0237 LIQUID 4 mg TOPICAL NDA 14 sections
Denti-Care Denti-RinseChlorhexidine Gluconate Oral Rinse HUMAN PRESCRIPTION DRUG LABEL 1 0116-0244 LIQUID 1.20 mg DENTAL ANDA 13 sections
Chlorhexidine Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 0116-0301 RINSE 1.20 mg ORAL ANDA 19 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0401 LIQUID 4 mg TOPICAL NDA 14 sections
ANTISEPTIC SKIN CLEANSER HUMAN PRESCRIPTION DRUG LABEL 1 0116-0407 SOLUTION 4 g TOPICAL NDA 15 sections
BD E-Z Scrub HUMAN OTC DRUG LABEL 1 0116-0505 SOLUTION 40 g TOPICAL NDA 14 sections
BD E-Z Scrub HUMAN OTC DRUG LABEL 1 0116-0506 SOLUTION 20 mg TOPICAL NDA 14 sections
Peridex HUMAN PRESCRIPTION DRUG LABEL 1 0116-0620 RINSE 1.20 mg ORAL NDA 21 sections
Scrub CareExidine-2 CHG HUMAN OTC DRUG LABEL 1 0116-0722 SOLUTION 2 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0767 LIQUID 4 g TOPICAL NDA 13 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0767 LIQUID 4 g TOPICAL NDA 13 sections
NUPRO Chlorhexidine Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 0116-0800 RINSE 1.20 mg ORAL ANDA 20 sections
DYNA-HEX2 HUMAN OTC DRUG LABEL 1 0116-1021 LIQUID 2 g TOPICAL NDA 13 sections
DYNA-HEX2 HUMAN OTC DRUG LABEL 1 0116-1021 LIQUID 2 g TOPICAL NDA 13 sections
Dyna-Hex 2 HUMAN OTC DRUG LABEL 1 0116-1022 SOLUTION 20 mg TOPICAL NDA 14 sections
DYNA-HEX 4 HUMAN OTC DRUG LABEL 1 0116-1060 LIQUID 4 g TOPICAL NDA 14 sections
ANTISEPTIC SKIN CLEANSER HUMAN OTC DRUG LABEL 1 0116-1061 SOLUTION 4 g TOPICAL NDA 13 sections
ANTISEPTIC SKIN CLEANSER HUMAN OTC DRUG LABEL 1 0116-1061 SOLUTION 4 g TOPICAL NDA 13 sections
ANTISEPTIC SKIN CLEANSER HUMAN OTC DRUG LABEL 1 0116-1061 SOLUTION 4 g TOPICAL NDA 13 sections
Bactoshield CHG HUMAN OTC DRUG LABEL 1 0116-1322 SOLUTION 20 mg TOPICAL NDA 16 sections