chlorhexidine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
597 55-56-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chlorhexidine hydrochloride
  • chlorhexidine
  • chlorohex
  • chlorohexidine
  • chlorhexidine gluconate
A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
  • Molecular weight: 505.45
  • Formula: C22H30Cl2N10
  • CLOGP: 4.81
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 10
  • TPSA: 167.58
  • ALOGS: -4.29
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 17, 1976 FDA MOLNLYCKE HLTH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3092.40 12.26 1720 34875 144200 46505267
Toxicity to various agents 1776.66 12.26 1402 35193 210364 46439103
Drug abuse 676.77 12.26 487 36108 62921 46586546
Intentional overdose 641.45 12.26 476 36119 64468 46584999
Cardio-respiratory arrest 605.11 12.26 445 36150 59424 46590043
Suicide attempt 398.01 12.26 336 36259 54700 46594767
Overdose 390.44 12.26 439 36156 101540 46547927
Alcohol interaction 329.49 12.26 108 36487 2337 46647130
Lower respiratory tract infection 257.83 12.26 264 36331 54825 46594642
Muscle spasticity 256.69 12.26 141 36454 11299 46638168
Muscle injury 224.07 12.26 98 36497 4768 46644699
Folliculitis 204.33 12.26 99 36496 6104 46643363
Ear pain 195.74 12.26 152 36443 21940 46627527
Suspected suicide 195.74 12.26 88 36507 4573 46644894
Alcohol poisoning 188.96 12.26 70 36525 2198 46647269
Body temperature increased 175.85 12.26 150 36445 24711 46624756
Alcohol use 159.08 12.26 63 36532 2379 46647088
Respiratory disorder 155.97 12.26 146 36449 27154 46622313
Sleep disorder due to general medical condition, insomnia type 155.68 12.26 78 36517 5171 46644296
Night sweats 150.45 12.26 143 36452 27107 46622360
Respiratory arrest 143.70 12.26 154 36441 33662 46615805
Intentional product misuse 137.54 12.26 177 36418 46951 46602516
Drug ineffective 134.50 12.26 203 36392 677635 45971832
Alcohol abuse 127.53 12.26 52 36543 2120 46647347
Irritable bowel syndrome 119.54 12.26 101 36494 16414 46633053
Application site rash 112.41 12.26 50 36545 2532 46646935
Ill-defined disorder 103.25 12.26 116 36479 26711 46622756
Cardiac arrest 101.55 12.26 221 36374 90178 46559289
Peripheral swelling 95.01 12.26 306 36289 157765 46491702
Sinusitis 93.73 12.26 268 36327 129500 46519967
Chemical burn 88.16 12.26 25 36570 324 46649143
Postoperative wound infection 81.38 12.26 62 36533 8691 46640776
Coma 78.86 12.26 154 36441 58195 46591272
Impaired healing 75.91 12.26 117 36478 36626 46612841
Blister 73.14 12.26 128 36467 44503 46604964
Somnolence 68.35 12.26 273 36322 156248 46493219
Nausea 68.18 12.26 293 36302 687161 45962306
Pruritus 65.74 12.26 368 36227 241984 46407483
Urticaria 65.21 12.26 222 36373 117670 46531797
Joint swelling 64.17 12.26 279 36316 165794 46483673
Blood alcohol increased 61.99 12.26 23 36572 725 46648742
Product dose omission issue 57.77 12.26 30 36565 168490 46480977
Rheumatoid arthritis 56.53 12.26 63 36532 240152 46409315
Fall 55.37 12.26 109 36486 328988 46320479
Alcoholism 54.36 12.26 29 36566 2189 46647278
Cough 49.28 12.26 65 36530 230184 46419283
Exposure to toxic agent 48.43 12.26 26 36569 1988 46647479
Poisoning deliberate 48.37 12.26 44 36551 7882 46641585
Ejection fraction 48.32 12.26 18 36577 574 46648893
Product package associated injury 46.94 12.26 9 36586 14 46649453
Administration site rash 45.63 12.26 11 36584 71 46649396
Dermatitis contact 45.52 12.26 43 36552 8080 46641387
Insomnia 44.35 12.26 250 36345 164674 46484793
Substance abuse 44.30 12.26 32 36563 4135 46645332
Stomatitis 43.49 12.26 135 36460 68162 46581305
Mydriasis 42.94 12.26 47 36548 10506 46638961
Victim of sexual abuse 42.32 12.26 16 36579 532 46648935
Dizziness 42.18 12.26 132 36463 340282 46309185
Injection site pain 39.90 12.26 17 36578 107135 46542332
Urticaria thermal 39.08 12.26 10 36585 85 46649382
Condition aggravated 38.77 12.26 84 36511 244968 46404499
Postmortem blood drug level abnormal 38.26 12.26 13 36582 315 46649152
Aggression 38.25 12.26 66 36529 22678 46626789
Cardiac failure congestive 35.05 12.26 14 36581 91736 46557731
Myocardial infarction 33.94 12.26 17 36578 97511 46551956
Gastrointestinal disorder 33.61 12.26 113 36482 59463 46590004
General physical health deterioration 33.58 12.26 25 36570 115744 46533723
Psoriasis 33.47 12.26 10 36585 78594 46570873
Application site erythema 33.46 12.26 29 36566 4875 46644592
Anaemia 33.21 12.26 97 36498 255682 46393785
Asthma 31.79 12.26 16 36579 91526 46557941
Off label use 31.58 12.26 172 36423 379669 46269798
Loss of personal independence in daily activities 31.18 12.26 4 36591 57179 46592288
Intentional self-injury 30.48 12.26 62 36533 24104 46625363
Loss of consciousness 30.35 12.26 166 36429 108072 46541395
Asthenopia 30.27 12.26 19 36576 1947 46647520
Dehydration 30.23 12.26 49 36546 159491 46489976
Occupational exposure to product 29.99 12.26 18 36577 1703 46647764
Osteonecrosis of jaw 29.75 12.26 76 36519 34326 46615141
Malaise 29.19 12.26 147 36448 331085 46318382
Burkholderia test positive 29.08 12.26 8 36587 92 46649375
Chest pain 29.07 12.26 59 36536 176265 46473202
Allergy to chemicals 29.04 12.26 14 36581 853 46648614
Gastrointestinal toxicity 28.32 12.26 25 36570 4306 46645161
Duodenal ulcer perforation 28.08 12.26 34 36561 8468 46640999
Cerebrovascular accident 27.80 12.26 23 36572 101016 46548451
Fatigue 27.66 12.26 325 36270 608372 46041095
Cytokine release syndrome 27.58 12.26 29 36566 6194 46643273
Anaphylactic reaction 27.57 12.26 98 36497 53014 46596453
Catheter site injury 27.20 12.26 7 36588 61 46649406
Muscle spasms 27.09 12.26 34 36561 123079 46526388
Somnambulism 26.96 12.26 26 36569 5011 46644456
Interstitial lung disease 26.63 12.26 5 36590 53944 46595523
Wound secretion 26.58 12.26 23 36572 3857 46645610
Decreased appetite 26.26 12.26 72 36523 193764 46455703
Death 26.08 12.26 388 36207 335160 46314307
Catheter site erythema 26.06 12.26 23 36572 3960 46645507
Bronchitis 25.77 12.26 27 36568 105952 46543515
Rash 25.32 12.26 406 36189 356106 46293361
Feeling abnormal 25.03 12.26 37 36558 125023 46524444
Catheter site rash 24.72 12.26 12 36583 742 46648725
Burkholderia infection 24.61 12.26 4 36591 0 46649467
Drug use disorder 24.60 12.26 19 36576 2716 46646751
Sinus tachycardia 24.35 12.26 53 36542 21596 46627871
Incorrect route of product administration 24.28 12.26 45 36550 16338 46633129
Application site irritation 24.11 12.26 16 36579 1803 46647664
Application site pruritus 23.94 12.26 22 36573 3991 46645476
Homicide 23.89 12.26 10 36585 436 46649031
Inappropriate schedule of product administration 23.12 12.26 11 36584 65002 46584465
Alopecia 23.00 12.26 59 36536 162355 46487112
Application site dermatitis 22.98 12.26 8 36587 209 46649258
Pulmonary toxicity 22.84 12.26 23 36572 4670 46644797
Agitation 22.82 12.26 95 36500 55320 46594147
Corneal defect 22.37 12.26 4 36591 3 46649464
Gait disturbance 21.96 12.26 51 36544 145212 46504255
Weight decreased 21.89 12.26 88 36507 210761 46438706
Chemical submission 21.81 12.26 8 36587 244 46649223
Abdominal pain upper 21.72 12.26 191 36404 145114 46504353
Injection site erythema 21.67 12.26 16 36579 74411 46575056
Drug dependence 21.56 12.26 48 36547 19853 46629614
Burkholderia cepacia complex infection 21.54 12.26 7 36588 147 46649320
Dysmetropsia 21.36 12.26 6 36589 75 46649392
Contraindicated product administered 21.33 12.26 121 36474 79826 46569641
Drug withdrawal syndrome 21.14 12.26 58 36537 27326 46622141
Leukopenia 20.81 12.26 14 36581 68329 46581138
Upper respiratory tract infection 20.76 12.26 12 36583 63544 46585923
Protein C increased 20.67 12.26 7 36588 168 46649299
Pyogenic granuloma 20.40 12.26 8 36587 294 46649173
Hepatotoxicity 20.34 12.26 54 36541 24955 46624512
Poisoning 20.19 12.26 38 36557 13956 46635511
Liver injury 20.12 12.26 41 36554 15960 46633507
Catheter site inflammation 19.85 12.26 10 36585 670 46648797
Pneumonia 19.83 12.26 194 36401 376126 46273341
Haemoglobin decreased 19.71 12.26 45 36550 128904 46520563
Myocarditis 19.39 12.26 27 36568 7712 46641755
Migraine 19.19 12.26 16 36579 70010 46579457
Substance dependence 18.91 12.26 7 36588 219 46649248
Application site hypersensitivity 18.91 12.26 7 36588 219 46649248
Product contamination microbial 18.82 12.26 7 36588 222 46649245
Renal failure 18.72 12.26 38 36557 113556 46535911
Diabetes mellitus 18.53 12.26 8 36587 50057 46599410
Arthritis 18.45 12.26 20 36575 77296 46572171
Helicobacter infection 18.36 12.26 33 36562 11703 46637764
Electrocardiogram QRS complex prolonged 18.34 12.26 22 36573 5427 46644040
Suicidal ideation 18.23 12.26 90 36505 56292 46593175
Tachycardia 18.15 12.26 137 36458 99485 46549982
Cardiac disorder 17.92 12.26 6 36589 43852 46605615
Blood glucose increased 17.90 12.26 18 36577 71995 46577472
Injury corneal 17.76 12.26 5 36590 63 46649404
Hypoaesthesia 17.75 12.26 42 36553 118827 46530640
Induced abortion failed 17.70 12.26 7 36588 263 46649204
Alcoholic 17.62 12.26 5 36590 65 46649402
Cystitis noninfective 17.61 12.26 10 36585 853 46648614
Therapeutic product effect decreased 17.61 12.26 118 36477 82483 46566984
Application site vesicles 17.32 12.26 12 36583 1452 46648015
Influenza 17.29 12.26 27 36568 89243 46560224
Hypersensitivity 17.27 12.26 187 36408 150134 46499333
Influenza like illness 17.25 12.26 12 36583 57558 46591909
Blood pressure increased 17.18 12.26 47 36548 126619 46522848
Injection site reaction 17.16 12.26 8 36587 47841 46601626
Accidental death 17.06 12.26 13 36582 1822 46647645
Confusional state 17.04 12.26 196 36399 159696 46489771
Cardiac ventricular thrombosis 16.98 12.26 8 36587 463 46649004
Congenital umbilical hernia 16.86 12.26 8 36587 470 46648997
Multiple sclerosis relapse 16.80 12.26 6 36589 42119 46607348
Fibromyalgia 16.72 12.26 4 36591 36459 46613008
Back pain 16.72 12.26 244 36351 209795 46439672
Accidental exposure to product 16.62 12.26 45 36550 21036 46628431
Diverticulitis 16.44 12.26 3 36592 33036 46616431
Lip injury 16.43 12.26 9 36586 716 46648751
Application site necrosis 16.38 12.26 3 36592 3 46649464
Extradural abscess 16.34 12.26 9 36586 724 46648743
Rhinovirus infection 16.21 12.26 17 36578 3619 46645848
Therapeutic product effect incomplete 15.75 12.26 23 36572 78130 46571337
Asphyxia 15.51 12.26 20 36575 5306 46644161
Pain in extremity 15.50 12.26 129 36466 258551 46390916
Urinary tract infection 15.50 12.26 105 36490 220161 46429306
Treatment failure 15.45 12.26 31 36564 93056 46556411
Constipation 15.45 12.26 77 36518 174020 46475447
Gastrointestinal haemorrhage 15.37 12.26 23 36572 77350 46572117
Recalled product administered 15.01 12.26 6 36589 232 46649235
Circulatory collapse 14.93 12.26 44 36551 21580 46627887
Transmission of an infectious agent via product 14.88 12.26 5 36590 117 46649350
Psoriatic arthropathy 14.82 12.26 5 36590 36374 46613093
Neutropenic sepsis 14.81 12.26 31 36564 12293 46637174
Parathyroid hyperplasia 14.68 12.26 5 36590 122 46649345
Hypertension 14.62 12.26 92 36503 196264 46453203
Dyspnoea 14.59 12.26 301 36294 515247 46134220
Electrocardiogram QT prolonged 14.56 12.26 79 36516 51246 46598221
Oedema peripheral 14.54 12.26 70 36525 159636 46489831
Platelet count decreased 14.41 12.26 36 36559 99988 46549479
Pancytopenia 14.40 12.26 28 36567 85030 46564437
Musculoskeletal stiffness 14.33 12.26 35 36560 97958 46551509
Myalgia 14.31 12.26 49 36546 123039 46526428
Breast cancer 14.29 12.26 9 36586 45509 46603958
Arthralgia 14.15 12.26 201 36394 364402 46285065
Catheter site pruritus 14.10 12.26 12 36583 1967 46647500
Catheter site vesicles 14.09 12.26 6 36589 273 46649194
Pulmonary oedema 14.06 12.26 78 36517 51027 46598440
Toxicologic test abnormal 14.00 12.26 8 36587 691 46648776
Abdominal discomfort 13.91 12.26 66 36529 151099 46498368
Infection 13.89 12.26 163 36432 133429 46516038
Purulent discharge 13.85 12.26 18 36577 4812 46644655
Oropharyngeal pain 13.83 12.26 23 36572 74145 46575322
Genital rash 13.79 12.26 7 36588 477 46648990
Polymenorrhagia 13.69 12.26 4 36591 58 46649409
Thrombocytopenia 13.65 12.26 52 36543 126529 46522938
Parvimonas micra infection 13.64 12.26 3 36592 12 46649455
Application site reaction 13.58 12.26 8 36587 731 46648736
Neck pain 13.54 12.26 14 36581 55292 46594175
No adverse event 13.44 12.26 5 36590 34226 46615241
Productive cough 13.39 12.26 12 36583 50703 46598764
Wrong technique in product usage process 13.07 12.26 14 36581 54408 46595059
Mobility decreased 13.04 12.26 17 36578 60577 46588890
Derealisation 12.97 12.26 8 36587 795 46648672
White blood cell count decreased 12.83 12.26 45 36550 112186 46537281
Shock 12.82 12.26 42 36553 21803 46627664
Blood pressure fluctuation 12.73 12.26 4 36591 30444 46619023
Hyponatraemia 12.71 12.26 39 36556 101293 46548174
Syncope 12.68 12.26 41 36554 104762 46544705
Aspiration 12.67 12.26 25 36570 9506 46639961
Alcohol withdrawal syndrome 12.66 12.26 8 36587 829 46648638
Chronic obstructive pulmonary disease 12.58 12.26 16 36579 57617 46591850
Cardiac death 12.56 12.26 7 36588 576 46648891
Metastases to bone 12.49 12.26 36 36559 17440 46632027
Blood cholesterol increased 12.44 12.26 8 36587 40005 46609462
Hyperlipasaemia 12.33 12.26 7 36588 597 46648870

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2346.58 13.00 1239 25892 80833 29844514
Completed suicide 2314.46 13.00 1310 25821 98182 29827165
Toxicity to various agents 2131.84 13.00 1537 25594 175646 29749701
Intentional overdose 595.61 13.00 404 26727 41077 29884270
Cardio-respiratory arrest 489.55 13.00 409 26722 56897 29868450
Alcohol abuse 472.36 13.00 179 26952 5174 29920173
Overdose 418.09 13.00 445 26686 83892 29841455
Suicide attempt 392.36 13.00 299 26832 36398 29888949
Alcohol interaction 363.66 13.00 124 27007 2618 29922729
Intentional product misuse 339.07 13.00 268 26863 34399 29890948
Alcohol poisoning 214.72 13.00 92 27039 3672 29921675
Suspected suicide 213.01 13.00 87 27044 3074 29922273
Substance abuse 201.32 13.00 107 27024 6933 29918414
Drug dependence 151.13 13.00 137 26994 21158 29904189
Alcohol use 148.22 13.00 71 27060 3684 29921663
Anaphylactic reaction 130.02 13.00 143 26988 27839 29897508
Drug ineffective 126.90 13.00 76 27055 340311 29585036
Recalled product administered 111.15 13.00 32 27099 376 29924971
Burkholderia test positive 107.42 13.00 32 27099 427 29924920
Respiratory arrest 103.44 13.00 130 27001 29128 29896219
Poisoning deliberate 95.33 13.00 62 27069 5842 29919505
Asphyxia 95.11 13.00 60 27071 5365 29919982
Incorrect route of product administration 92.67 13.00 79 27052 11236 29914111
Burkholderia infection 91.86 13.00 21 27110 87 29925260
Aggression 89.87 13.00 137 26994 36770 29888577
Coma 88.58 13.00 143 26988 40306 29885041
Blood alcohol increased 85.22 13.00 32 27099 899 29924448
Cardiac arrest 82.87 13.00 227 26904 92623 29832724
Respiratory depression 77.67 13.00 72 27059 11431 29913916
Product contamination microbial 76.41 13.00 27 27104 635 29924712
Intentional product use issue 71.96 13.00 123 27008 36317 29889030
Recalled product 58.01 13.00 19 27112 352 29924995
Alcohol withdrawal syndrome 55.87 13.00 28 27103 1603 29923744
Intentional self-injury 55.75 13.00 65 27066 13467 29911880
Poisoning 52.54 13.00 58 27073 11324 29914023
Drug withdrawal syndrome 51.71 13.00 76 27055 19733 29905614
Fatigue 51.71 13.00 136 26995 320537 29604810
Suicidal ideation 50.26 13.00 105 27026 36009 29889338
Burkholderia cepacia complex infection 48.51 13.00 14 27117 166 29925181
Diarrhoea 45.69 13.00 153 26978 333950 29591397
Chemical burn of skin 45.07 13.00 10 27121 35 29925312
Accidental death 41.54 13.00 25 27106 2054 29923293
Off label use 41.45 13.00 104 27027 249186 29676161
Sopor 39.07 13.00 49 27082 10942 29914405
Road traffic accident 38.22 13.00 61 27070 17010 29908337
Ex-drug abuser 37.70 13.00 12 27119 202 29925145
Myocardial infarction 37.64 13.00 35 27096 125590 29799757
Interstitial lung disease 37.63 13.00 5 27126 60192 29865155
Alcoholism 36.80 13.00 28 27103 3386 29921961
Drug screen positive 36.55 13.00 31 27100 4376 29920971
Alcohol intolerance 36.23 13.00 14 27117 426 29924921
Pneumonia 36.18 13.00 168 26963 334138 29591209
Sputum culture positive 35.50 13.00 22 27109 1905 29923442
Amnesia 35.34 13.00 72 27059 24249 29901098
Anaemia 35.15 13.00 86 27045 207906 29717441
Chemical burn 34.25 13.00 11 27120 191 29925156
Tachycardia 32.00 13.00 142 26989 73597 29851750
Acanthamoeba keratitis 31.80 13.00 9 27122 99 29925248
Medication error 31.56 13.00 63 27068 20909 29904438
Nausea 31.06 13.00 151 26980 296806 29628541
General physical health deterioration 30.94 13.00 27 27104 99917 29825430
Disease progression 30.79 13.00 17 27114 79857 29845490
Allergy to chemicals 30.65 13.00 8 27123 63 29925284
Cough 30.04 13.00 42 27089 125600 29799747
Arthralgia 29.94 13.00 48 27083 135743 29789604
Hepatic fibrosis 29.31 13.00 25 27106 3555 29921792
Product dose omission issue 29.29 13.00 24 27107 91607 29833740
Exposure to toxic agent 29.08 13.00 16 27115 1109 29924238
Asthenia 29.04 13.00 103 27028 221187 29704160
Application site vesicles 28.96 13.00 13 27118 580 29924767
Malignant neoplasm progression 28.42 13.00 15 27116 72272 29853075
Suspected transmission of an infectious agent via product 28.35 13.00 12 27119 464 29924883
Physical assault 27.96 13.00 16 27115 1197 29924150
Application site rash 27.71 13.00 14 27117 815 29924532
Homicide 27.38 13.00 15 27116 1031 29924316
Drug abuser 26.75 13.00 26 27105 4375 29920972
Miosis 26.58 13.00 34 27097 7742 29917605
Dyspnoea 26.55 13.00 185 26946 333110 29592237
Decreased appetite 26.08 13.00 61 27070 149849 29775498
Foetal alcohol syndrome 25.90 13.00 9 27122 201 29925146
Osteonecrosis of jaw 25.73 13.00 54 27077 18564 29906783
Dermatitis contact 25.31 13.00 22 27109 3209 29922138
Condition aggravated 24.87 13.00 55 27076 137811 29787536
White blood cell count decreased 24.41 13.00 24 27107 83923 29841424
Sensitisation 23.71 13.00 8 27123 163 29925184
Cardiac failure congestive 23.56 13.00 25 27106 84382 29840965
Weight increased 23.47 13.00 20 27111 74893 29850454
Accident 23.20 13.00 22 27109 3591 29921756
Dysarthria 22.75 13.00 70 27061 30420 29894927
Culture positive 22.50 13.00 12 27119 782 29924565
Depressed level of consciousness 21.66 13.00 80 27051 38142 29887205
Impaired driving ability 21.47 13.00 18 27113 2500 29922847
Weight decreased 21.31 13.00 68 27063 150853 29774494
Drug use disorder 21.28 13.00 20 27111 3228 29922119
Somnolence 21.10 13.00 155 26976 96608 29828739
Oedema peripheral 20.96 13.00 40 27091 105792 29819555
Pain in extremity 20.68 13.00 43 27088 110178 29815169
Agitation 20.41 13.00 100 27031 53973 29871374
Gun shot wound 20.37 13.00 13 27118 1185 29924162
Musculoskeletal stiffness 20.14 13.00 4 27127 35877 29889470
Back pain 20.12 13.00 39 27092 102557 29822790
Capillary nail refill test abnormal 19.80 13.00 5 27126 34 29925313
Dextrocardia 19.60 13.00 7 27124 170 29925177
Paranoia 19.58 13.00 34 27097 10154 29915193
Peripheral swelling 19.50 13.00 16 27115 61058 29864289
Shock 19.46 13.00 55 27076 22804 29902543
Dehydration 19.36 13.00 53 27078 123486 29801861
Catheter site rash 18.59 13.00 7 27124 198 29925149
Hepatic haematoma 18.57 13.00 9 27122 479 29924868
Therapeutic product effect incomplete 18.52 13.00 4 27127 33830 29891517
Drug intolerance 18.39 13.00 9 27122 45282 29880065
Asthma 18.38 13.00 5 27126 36169 29889178
Product use in unapproved indication 18.24 13.00 24 27107 73669 29851678
Joint swelling 18.07 13.00 10 27121 46936 29878411
Cerebrovascular accident 17.92 13.00 30 27101 83447 29841900
Cardiac failure 17.89 13.00 30 27101 83388 29841959
Renal failure 17.58 13.00 59 27072 128907 29796440
Catheter site discharge 17.48 13.00 9 27122 545 29924802
Myalgia 16.97 13.00 27 27104 76640 29848707
Pulseless electrical activity 16.52 13.00 24 27107 6163 29919184
Haemoglobin decreased 16.38 13.00 51 27080 114047 29811300
Pulmonary oedema 16.36 13.00 81 27050 43894 29881453
Product contamination 16.15 13.00 9 27122 640 29924707
Metabolic acidosis 16.13 13.00 72 27059 37389 29887958
Alcoholic liver disease 16.02 13.00 9 27122 650 29924697
Product package associated injury 15.95 13.00 3 27128 3 29925344
Somnambulism 15.91 13.00 17 27114 3197 29922150
Nasopharyngitis 15.79 13.00 18 27113 58831 29866516
Pyrexia 15.69 13.00 181 26950 294308 29631039
Unresponsive to stimuli 15.56 13.00 56 27075 26363 29898984
Hypotension 15.35 13.00 261 26870 200304 29725043
Application site irritation 15.31 13.00 9 27122 708 29924639
Blood glucose increased 15.26 13.00 20 27111 61510 29863837
Mydriasis 15.21 13.00 23 27108 6120 29919227
Abnormal behaviour 14.83 13.00 54 27077 25569 29899778
Loss of consciousness 14.46 13.00 122 27009 79253 29846094
Catheter site irritation 14.42 13.00 5 27126 111 29925236
Bladder discomfort 14.42 13.00 5 27126 111 29925236
Suicidal behaviour 14.30 13.00 11 27120 1351 29923996
Cluster headache 14.29 13.00 8 27123 574 29924773
Pulmonary embolism 14.21 13.00 31 27100 78104 29847243
Platelet count decreased 14.15 13.00 49 27082 106080 29819267
Product preparation error 14.14 13.00 12 27119 1694 29923653
Dizziness 14.12 13.00 111 27020 194798 29730549
Chemical poisoning 14.01 13.00 5 27126 121 29925226
Toxicologic test abnormal 13.90 13.00 8 27123 605 29924742
Death 13.81 13.00 422 26709 356861 29568486
Infusion related reaction 13.74 13.00 10 27121 40554 29884793
Skin abrasion 13.70 13.00 22 27109 6164 29919183
Pneumonitis 13.57 13.00 4 27127 27450 29897897
Disturbance in social behaviour 13.55 13.00 11 27120 1460 29923887
Anion gap 13.51 13.00 8 27123 638 29924709
Application site reaction 13.40 13.00 7 27124 437 29924910
Drug diversion 13.29 13.00 9 27122 907 29924440
Renal impairment 13.26 13.00 36 27095 84148 29841199
Non-cardiogenic pulmonary oedema 13.03 13.00 8 27123 681 29924666

Pharmacologic Action:

SourceCodeDescription
ATC A01AB03 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Antiinfectives and antiseptics for local oral treatment
ATC B05CA02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Antiinfectives
ATC D08AC02 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Biguanides and amidines
ATC D09AA12 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA05 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
ATC S01AX09 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Other antiinfectives
ATC S02AA09 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
ATC S03AA04 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
ANTIINFECTIVES
Antiinfectives
ATC D08AC52 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Biguanides and amidines
FDA PE N0000008478 Decreased Cell Wall Integrity
CHEBI has role CHEBI:33282 antibacterials
CHEBI has role CHEBI:35441 anti-infective drugs
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003879 Dermatologic Agents
MeSH PA D003358 Cosmetics
MeSH PA D004202 Disinfectants
MeSH PA D009067 Mouthwashes

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Gingivitis indication 66383009 DOID:3087
Mouth Infection Prevention indication
Denture stomatitis off-label use 69254008 DOID:11875
Aphthous ulcer of mouth off-label use 426965005 DOID:9663
Dental Plaque Prevention off-label use
Periodontitis contraindication 41565005 DOID:824
Open wound contraindication 125643001
Front Tooth Fillings contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.17 Basic
pKa2 10.57 Basic
pKa3 3.32 Basic
pKa4 2.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3.15%;70% (1.6ML) PREVANTICS SWABSTICK PROF DSPLS N021524 June 3, 2005 OTC SWAB TOPICAL Feb. 14, 2021 DRUG FACTS LABELING CHANGES UNDER THE DIRECTIONS HEADING TO REVISE THE STATED PREPARATION TIME OF A DRY SITE FROM 120 SECONDS SCRUBBING AND 90 SECONDS DRYING TO 30 SECONDS SCRUBBING AND 30 SECONDS DRYING
3.15%;70% (1ML) PREVANTICS SWAB PROF DSPLS N021524 June 3, 2005 OTC SWAB TOPICAL Feb. 14, 2021 DRUG FACTS LABELING CHANGES UNDER THE DIRECTIONS HEADING TO REVISE THE STATED PREPARATION TIME OF A DRY SITE FROM 120 SECONDS SCRUBBING AND 90 SECONDS DRYING TO 30 SECONDS SCRUBBING AND 30 SECONDS DRYING
3.15%;70% (5.1ML) PREVANTICS MAXI SWABSTICK PROF DSPLS N021524 June 3, 2005 OTC SWAB TOPICAL Feb. 14, 2021 DRUG FACTS LABELING CHANGES UNDER THE DIRECTIONS HEADING TO REVISE THE STATED PREPARATION TIME OF A DRY SITE FROM 120 SECONDS SCRUBBING AND 90 SECONDS DRYING TO 30 SECONDS SCRUBBING AND 30 SECONDS DRYING
2%;70% SOLUPREP 3M HEALTH CARE N208288 Aug. 8, 2018 OTC SOLUTION TOPICAL Aug. 8, 2021 NEW PRODUCT
2% READYPREP CHG MEDLINE INDUSTRIES N207964 Nov. 20, 2018 OTC CLOTH TOPICAL Nov. 20, 2021 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 22 member 3 Transporter IC50 6.39 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 6.68 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 6.40 CHEMBL
Matrix metalloproteinase-9 Enzyme IC50 5.12 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 6.30 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 6.15 CHEMBL
72 kDa type IV collagenase Enzyme IC50 5.12 CHEMBL
Trypanothione reductase Enzyme Ki 5.70 CHEMBL
CAAX prenyl protease 2 Unclassified AC50 5.24 CHEMBL

External reference:

IDSource
D00858 KEGG_DRUG
18472-51-0 SECONDARY_CAS_RN
4019393 VANDF
4019673 VANDF
C0008196 UMLSCUI
CHEBI:3614 CHEBI
CHEMBL790 ChEMBL_ID
CHEMBL1628 ChEMBL_ID
CHEMBL4297088 ChEMBL_ID
CHEMBL1484251 ChEMBL_ID
DB00878 DRUGBANK_ID
D002710 MESH_DESCRIPTOR_UI
C010882 MESH_SUPPLEMENTAL_RECORD_UI
9552079 PUBCHEM_CID
500 INN_ID
R4KO0DY52L UNII
20791 RXNORM
4411 MMSL
6085 MMSL
003177 NDDF
003674 NDDF
003723 NDDF
108895000 SNOMEDCT_US
373568007 SNOMEDCT_US
767425002 SNOMEDCT_US
96316004 SNOMEDCT_US
96318003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Chlorhexidine Gluconate 0.12% Oral Rinse HUMAN PRESCRIPTION DRUG LABEL 1 0116-0003 LIQUID 1.20 [iU] BUCCAL ANDA 18 sections
Chlorhexidine Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 0116-0101 LIQUID 0.12 mg ORAL ANDA 17 sections
Cardinal Health Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0113 SOLUTION 2 g TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0115 LIQUID 4 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0137 LIQUID 4 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0161 LIQUID 4 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0162 LIQUID 4 mg TOPICAL NDA 14 sections
Chlorhexidine Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 0116-0175 RINSE 1.20 mg ORAL ANDA 17 sections
BETASEPT HUMAN PRESCRIPTION DRUG LABEL 1 0116-0200 SOLUTION 0.04 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0228 LIQUID 4 mg TOPICAL NDA 15 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0237 LIQUID 4 mg TOPICAL NDA 14 sections
Denti-Care Denti-RinseChlorhexidine Gluconate Oral Rinse HUMAN PRESCRIPTION DRUG LABEL 1 0116-0244 LIQUID 1.20 mg DENTAL ANDA 13 sections
Chlorhexidine Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 0116-0301 RINSE 1.20 mg ORAL ANDA 19 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0401 LIQUID 4 mg TOPICAL NDA 14 sections
ANTISEPTIC SKIN CLEANSER HUMAN PRESCRIPTION DRUG LABEL 1 0116-0407 SOLUTION 4 g TOPICAL NDA 15 sections
BD E-Z Scrub HUMAN OTC DRUG LABEL 1 0116-0505 SOLUTION 40 g TOPICAL NDA 14 sections
BD E-Z Scrub HUMAN OTC DRUG LABEL 1 0116-0506 SOLUTION 20 mg TOPICAL NDA 14 sections
Peridex HUMAN PRESCRIPTION DRUG LABEL 1 0116-0620 RINSE 1.20 mg ORAL NDA 21 sections
Scrub CareExidine-2 CHG HUMAN OTC DRUG LABEL 1 0116-0722 SOLUTION 2 mg TOPICAL NDA 14 sections
Antiseptic Skin Cleanser HUMAN OTC DRUG LABEL 1 0116-0767 LIQUID 4 g TOPICAL NDA 13 sections
NUPRO Chlorhexidine Gluconate HUMAN PRESCRIPTION DRUG LABEL 1 0116-0800 RINSE 1.20 mg ORAL ANDA 20 sections
DYNULL-HEX2 HUMAN OTC DRUG LABEL 1 0116-1021 LIQUID 2 g TOPICAL NDA 13 sections
DYNULL-HEX2 HUMAN OTC DRUG LABEL 1 0116-1021 LIQUID 2 g TOPICAL NDA 13 sections
Dyna-Hex 2 HUMAN OTC DRUG LABEL 1 0116-1022 SOLUTION 20 mg TOPICAL NDA 14 sections
DYNULL-HEX 4 HUMAN OTC DRUG LABEL 1 0116-1060 LIQUID 4 g TOPICAL NDA 14 sections
ANTISEPTIC SKIN CLEANSER HUMAN OTC DRUG LABEL 1 0116-1061 SOLUTION 4 g TOPICAL NDA 13 sections
ANTISEPTIC SKIN CLEANSER HUMAN OTC DRUG LABEL 1 0116-1061 SOLUTION 4 g TOPICAL NDA 13 sections
ANTISEPTIC SKIN CLEANSER HUMAN OTC DRUG LABEL 1 0116-1061 SOLUTION 4 g TOPICAL NDA 13 sections
Bactoshield CHG HUMAN OTC DRUG LABEL 1 0116-1322 SOLUTION 20 mg TOPICAL NDA 16 sections
Bactoshield CHG HUMAN OTC DRUG LABEL 1 0116-1344 SOLUTION 40 mg TOPICAL NDA 15 sections