fusidic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1261	6990-06-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: silver fusidate fusidic acid flucidin fucithalmic fusidinic acid ramycin sodium fusidate fusidic acid sodium fusidic acid sodium salt	An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis. Molecular weight: 516.72 Formula: C31H48O6 CLOGP: 7.28 LIPINSKI: 2 HAC: 6 HDO: 3 TPSA: 104.06 ALOGS: -5 ROTB: 6

Molecule

Description

Molfile Inchi Smiles

Synonyms:

silver fusidate
fusidic acid
flucidin
fucithalmic
fusidinic acid
ramycin
sodium fusidate
fusidic acid sodium
fusidic acid sodium salt

An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.

Molecular weight: 516.72
Formula: C31H48O6
CLOGP: 7.28
LIPINSKI: 2
HAC: 6
HDO: 3
TPSA: 104.06
ALOGS: -5
ROTB: 6

Drug dosage:

Dose	Unit	Route
1.50	g	O
1.50	g	P

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	91 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	50 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

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Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Eczema herpeticum	50.73	24.46	8	1945	161	63486908
Biliary sepsis	48.61	24.46	10	1943	921	63486148
Monocytosis	41.13	24.46	8	1945	554	63486515
Rash maculo-papular	38.37	24.46	19	1934	31877	63455192
Rhabdomyolysis	38.05	24.46	21	1932	43930	63443139
Scab	35.28	24.46	12	1941	7751	63479318
Hyperlipasaemia	33.39	24.46	7	1946	706	63486363
Ulcerative keratitis	33.24	24.46	9	1944	2701	63484368
Vulvovaginal inflammation	32.26	24.46	7	1946	832	63486237
Exposure to SARS-CoV-2	32.08	24.46	8	1945	1743	63485326

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rhabdomyolysis	194.68	29.13	82	1450	68081	34887318
Drug interaction	60.68	29.13	61	1471	225885	34729514
Chromaturia	56.73	29.13	22	1510	14498	34940901
Labelled drug-drug interaction medication error	52.62	29.13	21	1511	14918	34940481
Myalgia	41.11	29.13	32	1500	84078	34871321

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rhabdomyolysis	224.96	20.54	104	3501	103027	79637756
Drug interaction	64.31	20.54	86	3519	415097	79325686
Labelled drug-drug interaction medication error	51.22	20.54	25	3580	27625	79713158
Eczema herpeticum	49.27	20.54	9	3596	299	79740484
Rash maculo-papular	41.88	20.54	28	3577	56050	79684733
Biliary sepsis	39.27	20.54	10	3595	1607	79739176
Scab	37.20	20.54	15	3590	10557	79730226
Cholestasis	34.13	20.54	24	3581	52085	79688698
Monocytosis	33.27	20.54	8	3597	1016	79739767
Chromaturia	32.50	20.54	18	3587	25728	79715055

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	D06AX01	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use
ATC	D09AA02	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	J01XC01	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Steroid antibacterials
ATC	S01AA13	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics
CHEBI has role	CHEBI:48001	protein synthesis inhibitors
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77194	ATP:pantothenate 4-phosphotransferase inhibitor
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D004791	Enzyme Inhibitors

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Trachoma	indication	2576002	DOID:11265
Listeriosis	indication	4241002	DOID:11573
Septicemia due to Escherichia coli	indication	9323009
Bacterial septicemia	indication	10001005	DOID:0040085
Infection due to Pseudomonas aeruginosa	indication	11218009
Inhalational anthrax	indication	11389007
Actinomycotic infection	indication	11817007	DOID:8478
Folliculitis	indication	13600006	DOID:4409
Gonorrhea	indication	15628003	DOID:7551
Pneumococcal infectious disease	indication	16814004

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.75	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN	IC50	4.28	CHEMBL
Bile salt export pump	Transporter	O95342	ABCBB_HUMAN	IC50	4.94	CHEMBL
Bile salt export pump	Transporter		ABCBB_RAT	IC50	4.76	CHEMBL

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External reference:

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ID	Source
FUA	PDB_CHEM_ID
003486	NDDF
003488	NDDF
10815	IUPHAR_LIGAND_ID
1431	INN_ID
202636	RXNORM
3000226	PUBCHEM_CID
387530003	SNOMEDCT_US
395876005	SNOMEDCT_US
59XE10C19C	UNII

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Pharmaceutical products:

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