cetylpyridinium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3083 7773-52-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cetylpyridinium
  • ceepryn
  • hexadecylpyridinium
  • cetylpyridinium chloride
Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.
  • Molecular weight: 304.54
  • Formula: C21H38N
  • CLOGP: 3.74
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.88
  • ALOGS: -7.72
  • ROTB: 15

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal toxicity 104.16 32.78 23 977 4308 46680754
Pulmonary toxicity 96.89 32.78 22 978 4671 46680391
C-reactive protein abnormal 67.91 32.78 23 977 21247 46663815
Joint injury 66.19 32.78 22 978 19187 46665875
Neoplasm malignant 65.66 32.78 23 977 23476 46661586
Hepatotoxicity 64.26 32.78 23 977 24986 46660076
Therapy non-responder 56.45 32.78 24 976 41128 46643934
Joint stiffness 48.02 32.78 19 981 27089 46657973
Musculoskeletal pain 44.27 32.78 24 976 70104 46614958
Musculoskeletal stiffness 36.82 32.78 24 976 97969 46587093
Treatment failure 35.46 32.78 23 977 93064 46591998
Drug hypersensitivity 35.34 32.78 34 966 243791 46441271

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC B05CA01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Antiinfectives
ATC D08AJ03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D09AA07 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA06 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003902 Detergents
MeSH PA D013501 Surface-Active Agents
CHEBI has role CHEBI:35195 surface active agent
CHEBI has role CHEBI:48218 antiseptics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Local anesthesia indication 386761002
Mouth Irritation indication
Suppression of the Gag Reflex indication
Hypocupremia contraindication 19577007
Methemoglobinemia contraindication 38959009 DOID:10783
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Caspase-2 Enzyme EC50 4.68 CHEMBL
High affinity choline transporter 1 Unclassified Ki 4.49 CHEMBL

External reference:

IDSource
4019671 VUID
N0000147763 NUI
D07666 KEGG_DRUG
6004-24-6 SECONDARY_CAS_RN
4019096 VANDF
4019671 VANDF
C0007906 UMLSCUI
CHEBI:32915 CHEBI
CHEMBL2003538 ChEMBL_ID
CHEMBL305906 ChEMBL_ID
CHEMBL34833 ChEMBL_ID
DB11073 DRUGBANK_ID
D002594 MESH_DESCRIPTOR_UI
2683 PUBCHEM_CID
CUB7JI0JV3 UNII
2286 RXNORM
4401 MMSL
73038 MMSL
003144 NDDF
11719000 SNOMEDCT_US
387043006 SNOMEDCT_US
395927000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oral-BAnti-Bacterial HUMAN OTC DRUG LABEL 1 0041-1420 LIQUID 500 ug DENTAL OTC monograph not final 13 sections
Antiseptic HUMAN OTC DRUG LABEL 1 0869-0299 RINSE 0.07 kg ORAL OTC monograph not final 11 sections
Orajle Anti-Bacterial Rinse for Bleeding Gums HUMAN OTC DRUG LABEL 1 10237-721 LIQUID 0.00 mL ORAL OTC monograph not final 6 sections
Antiseptic HUMAN OTC DRUG LABEL 1 11673-299 RINSE 0.07 kg ORAL OTC monograph not final 13 sections
Antiseptic HUMAN OTC DRUG LABEL 1 11673-299 RINSE 0.70 mg ORAL OTC monograph not final 13 sections
Alcohol Free Antiseptic HUMAN OTC DRUG LABEL 1 11822-5761 MOUTHWASH 0.70 mg ORAL OTC monograph not final 12 sections
Mint HUMAN OTC DRUG LABEL 1 21130-299 MOUTHWASH 0.70 mg ORAL OTC monograph not final 10 sections
Roccos Old SchoolPeircing Armor HUMAN OTC DRUG LABEL 1 24488-011 SPRAY 0.03 mL TOPICAL OTC monograph not final 11 sections
Alcohol Free Antiseptic HUMAN OTC DRUG LABEL 1 30142-299 MOUTHWASH 0.70 mg ORAL OTC monograph not final 11 sections
Multi-Action Antiseptic HUMAN OTC DRUG LABEL 1 33992-0299 RINSE 0.70 mg ORAL OTC monograph not final 12 sections
AssuredOral Health Fresh Mint HUMAN OTC DRUG LABEL 1 33992-0320 RINSE 0.07 g ORAL OTC monograph not final 11 sections
Total Advanced Health Fresh Mint HUMAN OTC DRUG LABEL 1 35000-390 RINSE 0.75 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Colgate Total Advanced Pro-Shield Peppermint Blast HUMAN OTC DRUG LABEL 1 35000-720 RINSE 15 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Colgate Total Advanced Gum Health Mouthwash HUMAN OTC DRUG LABEL 1 35000-723 RINSE 0.75 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Colgate Total 12 Hr Pro-Shield Spearmint Surge HUMAN OTC DRUG LABEL 1 35000-731 RINSE 15 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Colgate Zero Healthy Gums HUMAN OTC DRUG LABEL 1 35000-880 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Colgate Zero Fresh Breath HUMAN OTC DRUG LABEL 1 35000-882 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Colgate Swish Mild Mint HUMAN OTC DRUG LABEL 1 35000-889 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Colgate Swish Refreshing Mint HUMAN OTC DRUG LABEL 1 35000-890 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Colgate Swish Invigorating Mint HUMAN OTC DRUG LABEL 1 35000-891 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Colgate Simply Fresh Mint HUMAN OTC DRUG LABEL 1 35000-892 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH NOT FINULLL 12 sections
Emerald Mint Health HUMAN OTC DRUG LABEL 1 36800-015 MOUTHWASH 0.07 g ORAL OTC monograph not final 11 sections
Alcohol Free Antiseptic Oral HUMAN OTC DRUG LABEL 1 36800-223 RINSE 0.07 mg ORAL OTC monograph not final 10 sections
Antiseptic HUMAN OTC DRUG LABEL 1 36800-299 RINSE 0.70 mg ORAL OTC monograph not final 12 sections
FixodentGum Care HUMAN OTC DRUG LABEL 1 37000-169 RINSE 0.07 g ORAL OTC monograph not final 11 sections
Crest Pro-Health Multi-ProtectionRefreshing Clean Mint HUMAN OTC DRUG LABEL 1 37000-451 RINSE 0.01 g ORAL OTC monograph not final 11 sections
Crest Pro-Health HUMAN OTC DRUG LABEL 1 37000-452 RINSE 0.01 g ORAL OTC monograph not final 11 sections
Crest Pro-HealthIntense Clean Mint HUMAN OTC DRUG LABEL 1 37000-479 RINSE 0.05 g ORAL OTC monograph not final 11 sections
Crest Pro-HealthIntense Fresh Mint HUMAN OTC DRUG LABEL 1 37000-480 RINSE 0.05 g ORAL OTC monograph not final 11 sections
CrestGum Care HUMAN OTC DRUG LABEL 1 37000-576 RINSE 0.01 g ORAL OTC monograph not final 11 sections