cetylpyridinium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 3083 7773-52-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cetylpyridinium
  • ceepryn
  • hexadecylpyridinium
  • cetylpyridinium chloride
Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.
  • Molecular weight: 304.54
  • Formula: C21H38N
  • CLOGP: 3.74
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.88
  • ALOGS: -7.72
  • ROTB: 15

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 60
kinase-selectivity-class AKT2,AKT3,AXL,CAMK2D,CDK4,EIF2AK3,EPHB4,GRK2,INSR,MAP2K6,MAPK10,MAPK12,MTOR,PDK4,PLK1,PLK2,PLK3,PLK4,PRKCD,PTK2,SIK2,STK33,TEK,TTK 24
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Streptococcal sepsis 36.62 33.61 8 764 3576 90624099
Pseudomonal sepsis 35.17 33.61 8 764 4294 90623381

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Streptococcal sepsis 33.30 28.36 8 1001 5064 110583226
Varicose vein 30.81 28.36 8 1001 6932 110581358
Metastases to lymph nodes 28.83 28.36 9 1000 15023 110573267
Pseudomonal sepsis 28.71 28.36 8 1001 9038 110579252

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AB53 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Antiinfectives and antiseptics for local oral treatment
ATC B05CA01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Antiinfectives
ATC D08AJ03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D09AA07 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA06 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003902 Detergents
MeSH PA D013501 Surface-Active Agents
CHEBI has role CHEBI:35195 surfactant
CHEBI has role CHEBI:48218 antiseptic drug

Related Drugs by ATC class:

A01AB Antiinfectives and antiseptics for local oral treatment 22 drugs
amphotericin Bbenzoxonium chloridechlorhexidinechlortetracyclineclotrimazoledomiphendoxycyclinehexetidinehydrogen peroxidemepartricinmetronidazolemiconazole show all 22 →
B05CA Antiinfectives 8 drugs
chlorhexidineethacridinemandelic acidneomycinnitrofurazonenoxytiolinsulfamethizoletaurolidine
D08AJ Quaternary ammonium compounds 9 drugs
benzalkoniumbenzethoniumbenzoxonium chloridecetrimidecetrimoniumdecamethoxinedidecyldimethylammonium chloridedodeclonium bromideoctenidine
D09AA Medicated dressings with antiinfectives 11 drugs
aluminium chlorohydratebenzalkoniumchlorhexidineclioquinolframycetinfusidic acidiodoformnitrofurazonephenylmercuric nitratepovidone-iodinetriclosan
R02AA Antiseptics 15 drugs
ambazonebenzalkoniumbenzethoniumcetrimoniumchlorhexidinechlorquinaldoldequaliniumdichlorobenzyl alcoholeuflavinehexamidinehexylresorcinoloctenidine show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Local anesthesia indication 386761002
Mouth Irritation indication
Suppression of the Gag Reflex indication
Hypocupremia contraindication 19577007
Methemoglobinemia contraindication 38959009 DOID:10783
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Caspase-2 Enzyme EC50 4.68 CHEMBL
High affinity choline transporter 1 Transporter Ki 4.49 CHEMBL

External reference:

IDSource
4019671 VUID
N0000147763 NUI
D07666 KEGG_DRUG
6004-24-6 SECONDARY_CAS_RN
4019096 VANDF
4019671 VANDF
C0007906 UMLSCUI
CHEMBL305906 ChEMBL_ID
CHEMBL2003538 ChEMBL_ID
DB11073 DRUGBANK_ID
D002594 MESH_DESCRIPTOR_UI
2683 PUBCHEM_CID
14498 IUPHAR_LIGAND_ID
CUB7JI0JV3 UNII
2286 RXNORM
4401 MMSL
73038 MMSL
003144 NDDF
11719000 SNOMEDCT_US
387043006 SNOMEDCT_US
395927000 SNOMEDCT_US
CHEBI:32915 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oral-BAnti-Bacterial HUMAN OTC DRUG LABEL 1 0041-1420 LIQUID 500 ug DENTAL OTC monograph not final 13 sections
Parodontax Active Gum Health Clear Mint HUMAN OTC DRUG LABEL 1 0135-0650 MOUTHWASH 0.70 mg ORAL OTC Monograph Drug 12 sections
Parodontax Active Gum Health Mint HUMAN OTC DRUG LABEL 1 0135-0651 MOUTHWASH 70 mg ORAL OTC Monograph Drug 12 sections
Parodontax Active Gum Health Daily Mouthwash Breath Freshener HUMAN OTC DRUG LABEL 1 0135-0652 LIQUID 70 mg ORAL OTC Monograph Drug 12 sections
Parodontax Gum Strengthen and Protect HUMAN OTC DRUG LABEL 1 0135-0654 RINSE 0.70 mg ORAL OTC Monograph Drug 11 sections
Health HUMAN OTC DRUG LABEL 1 0363-0099 MOUTHWASH 0.70 mg ORAL OTC Monograph Drug 13 sections
Cetylpyridinium Chloride HUMAN OTC DRUG LABEL 1 0363-9542 LIQUID 0.50 mg ORAL OTC Monograph Drug 12 sections
TheraBreath Healthy Gums HUMAN OTC DRUG LABEL 1 10237-258 RINSE 0.01 mg ORAL OTC Monograph Drug 11 sections
Therabreath Plaque Control HUMAN OTC DRUG LABEL 1 10237-259 RINSE 0.02 mg ORAL OTC Monograph Drug 11 sections
Therabreath Deep Clean Fresh Mint HUMAN OTC DRUG LABEL 1 10237-261 RINSE 20 mg ORAL OTC Monograph Drug 11 sections
Antiseptic HUMAN OTC DRUG LABEL 1 11344-299 RINSE 0.70 mg ORAL OTC Monograph Drug 12 sections
Antigingivitis/Antiplaque HUMAN OTC DRUG LABEL 1 11344-900 MOUTHWASH 0.70 mg ORAL OTC Monograph Drug 12 sections
Antiseptic HUMAN OTC DRUG LABEL 1 11673-299 MOUTHWASH 0.70 mg ORAL OTC Monograph Drug 13 sections
Alcohol Free Antiseptic HUMAN OTC DRUG LABEL 1 11822-5761 MOUTHWASH 0.70 mg ORAL OTC Monograph Drug 12 sections
Mint HUMAN OTC DRUG LABEL 1 21130-299 MOUTHWASH 0.70 mg ORAL OTC Monograph Drug 10 sections
Roccos Old SchoolPeircing Armor HUMAN OTC DRUG LABEL 1 24488-011 SPRAY 0.03 mL TOPICAL OTC monograph not final 11 sections
Killfire mouth freshener HUMAN OTC DRUG LABEL 1 24765-134 SPRAY 0.05 g ORAL unapproved drug other 8 sections
AssuredOral Health Fresh Mint HUMAN OTC DRUG LABEL 1 33992-0320 RINSE 0.07 g ORAL OTC monograph not final 11 sections
Colgate Total Active Prevention Peppermint HUMAN OTC DRUG LABEL 1 35000-279 RINSE 15 mg DENTAL OTC MONOGRAPH DRUG 11 sections
Colgate Total Active Prevention Spearmint HUMAN OTC DRUG LABEL 1 35000-280 RINSE 15 mg DENTAL OTC MONOGRAPH DRUG 12 sections
Colgate Total Active Prevention Gum Health HUMAN OTC DRUG LABEL 1 35000-281 RINSE 15 mg DENTAL OTC MONOGRAPH DRUG 12 sections
Hello Clean Mintwith aloe vera HUMAN OTC DRUG LABEL 1 35000-510 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH DRUG 12 sections
Hello Extra Mintywith extra cooling HUMAN OTC DRUG LABEL 1 35000-511 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH DRUG 11 sections
Hello Peace Out Plaque peace out, plaque antigingivitis HUMAN OTC DRUG LABEL 1 35000-683 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH DRUG 12 sections
Hello Peace Out Plaque peace out, plaque antigingivitis HUMAN OTC DRUG LABEL 1 35000-683 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH DRUG 12 sections
Hello empower mint HUMAN OTC DRUG LABEL 1 35000-690 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH DRUG 12 sections
Hello empower mint HUMAN OTC DRUG LABEL 1 35000-690 MOUTHWASH 15 mg DENTAL OTC MONOGRAPH DRUG 12 sections
Colgate Total Advanced Pro-Shield Peppermint Blast HUMAN OTC DRUG LABEL 1 35000-720 RINSE 15 mg DENTAL OTC MONOGRAPH DRUG 12 sections
Colgate Total Advanced Gum Health Mouthwash HUMAN OTC DRUG LABEL 1 35000-723 RINSE 0.75 mg DENTAL OTC MONOGRAPH DRUG 12 sections
Colgate Total 12 Hr Pro-Shield Spearmint Surge HUMAN OTC DRUG LABEL 1 35000-731 RINSE 15 mg DENTAL OTC MONOGRAPH DRUG 12 sections