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ozenoxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, nalidixic acid derivatives | 5058 | 245765-41-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Ozenoxacin is a quinolone antimicrobial drug. The mechanism of action involves the inhibition of bacterial DNA replication enzymes, DNA gyrase A and topoisomerase IV. Ozenoxacin has been shown to be bactericidal against S. aureus and S. pyogenes organisms. Ozenoxacin is used as topical treatment for impetigo and other infectious dermatological conditions.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.627 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.881 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 80.538 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 7.482 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 7.840 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 17.550 | % | High | 1 |
| herg | hERG pIC50 | 4.668 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.950 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 7.379 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 6.760 | % | High | 1 |
| kinase-safety-class | ACVR2B,GRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CD,PIK3CG,PRKDC | 9 | |||
| kinase-selectivity-class | ACVR2B,AXL,DYRK1B,EIF2AK3,GRK2,MAP2K6,MAPK7,PIK3CB,PIK3CD,PIK3CG,PRKDC,TGFBR1 | 12 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 2.518 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 12.246 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 6.250 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 6.427 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 11.580 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 4.246 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 62.670 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 2.700 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 46.452 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 11, 2017 | FDA | FERRER INTERNACIONAL S.A. | |
| Sept. 28, 2015 | PMDA | Maruho Co., Ltd. |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D06AX14 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D059003 | Topoisomerase Inhibitors |
| FDA CS | M0023650 | Quinolones |
| FDA EPC | N0000175937 | Quinolone Antimicrobial |
| CHEBI has role | CHEBI:73336 | vulnerary |
Related Drugs by ATC class:
D06AX Other antibiotics for topical use 12 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Acne vulgaris | indication | 88616000 | |
| Superficial bacterial infection of skin | indication | 275441009 | |
| Staphylococcal infection of skin | indication | 402938009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.46 | acidic |
| pKa2 | 5.8 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 1% | XEPI | LNHC | N208945 | Dec. 11, 2017 | DISCN | CREAM | TOPICAL | 9399014 | Dec. 15, 2029 | TREATMENT OF IMPETIGO DUE TO STAPHYLOCOCCUS AUREUS OR STREPTOCOCCUS PYOGENES |
| 1% | XEPI | LNHC | N208945 | Dec. 11, 2017 | DISCN | CREAM | TOPICAL | 9180200 | Jan. 29, 2032 | TREATMENT OF IMPETIGO DUE TO STAPHYLOCOCCUS AUREUS OR STREPTOCOCCUS PYOGENES |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| V0LH498RFO | UNII |
| D09544 | KEGG_DRUG |
| 4037917 | VANDF |
| C2983945 | UMLSCUI |
| CHEBI:136050 | CHEBI |
| CHEMBL3990047 | ChEMBL_ID |
| 9863827 | PUBCHEM_CID |
| DB12924 | DRUGBANK_ID |
| 8788 | INN_ID |
| C000592413 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10841 | IUPHAR_LIGAND_ID |
| C464965 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1994739 | RXNORM |
| 267098 | MMSL |
| 33338 | MMSL |
| 017429 | NDDF |
| 763879001 | SNOMEDCT_US |
| 763887000 | SNOMEDCT_US |
Pharmaceutical products:
None