felodipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 1142 72509-76-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • felodipine
  • (RS)-Felodipine
  • (+/-)-Felodipine
  • flodil
  • dl-Felodipine
A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
  • Molecular weight: 384.25
  • Formula: C18H19Cl2NO4
  • CLOGP: 5.30
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 1
  • TPSA: 64.63
  • ALOGS: -4.73
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.87 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,PDK1,PDK4,PDPK1,PIK3CB,PIK3CG,PRKDC,TEK 20
kinase-selectivity-class AXL,BRAF,GRK2,PDK4,PIK3CB,PIK3CD 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
July 25, 1991 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 357.95 17.92 93 19272 3353 90605729
Palmoplantar keratoderma 356.34 17.92 93 19272 3414 90605668
Pruritus genital 332.18 17.92 93 19272 4465 90604617
Sleep terror 320.40 17.92 90 19275 4374 90604708
Carotid artery occlusion 310.33 17.92 95 19270 6247 90602835
Atrial tachycardia 294.26 17.92 90 19275 5900 90603182
Tension headache 282.32 17.92 92 19273 7417 90601665
Anosmia 257.87 17.92 92 19273 9756 90599326
Vasculitis 247.95 17.92 113 19252 22580 90586502
Immunisation 236.02 17.92 61 19304 2152 90606930
Muscle twitching 234.83 17.92 111 19254 24091 90584991
Facial pain 228.27 17.92 91 19274 13091 90595991
Pain of skin 220.69 17.92 94 19271 15988 90593094
Subarachnoid haemorrhage 220.65 17.92 97 19268 17807 90591275
Tinnitus 215.81 17.92 127 19238 42975 90566107
Ventricular tachycardia 196.71 17.92 99 19266 24609 90584473
Lip swelling 191.28 17.92 113 19252 38497 90570585
Hallucination 189.06 17.92 137 19228 65822 90543260
Blindness 175.73 17.92 94 19271 26474 90582608
Eye pruritus 173.40 17.92 96 19269 28931 90580151
Diplopia 166.15 17.92 93 19272 28621 90580461
Angioedema 164.07 17.92 125 19240 64751 90544331
Transient ischaemic attack 157.39 17.92 104 19261 43072 90566010
Disturbance in attention 146.82 17.92 103 19262 47006 90562076
Palpitations 116.86 17.92 145 19220 136583 90472499
Rash papular 115.23 17.92 65 19300 20290 90588792
Hyponatraemia 100.54 17.92 133 19232 133405 90475677
Cognitive disorder 98.30 17.92 96 19269 69311 90539771
Myocardial infarction 98.02 17.92 117 19248 105855 90503227
Dehydration 96.29 17.92 159 19206 194288 90414794
Intentional product misuse 87.96 17.92 102 19263 89502 90519580
Tachycardia 84.95 17.92 134 19231 157539 90451543
Blood creatine increased 83.40 17.92 37 19328 6930 90602152
Blood glucose increased 81.32 17.92 101 19264 95145 90513937
Hyperhidrosis 80.67 17.92 121 19244 136184 90472898
Dry skin 79.40 17.92 96 19269 87977 90521105
Heart rate increased 76.69 17.92 107 19258 112795 90496287
Drug ineffective 73.00 17.92 115 19250 1384183 89224899
Visual impairment 69.23 17.92 111 19254 132254 90476828
Infusion related reaction 67.05 17.92 6 19359 416774 90192308
COVID-19 66.61 17.92 125 19240 168718 90440364
Amnesia 66.59 17.92 98 19267 108407 90500675
Dizziness 65.53 17.92 274 19091 589010 90020072
Arthropathy 62.51 17.92 4 19361 366238 90242844
Hypopnoea 61.10 17.92 26 19339 4405 90604677
Drug intolerance 58.91 17.92 12 19353 447579 90161503
Maternal exposure during pregnancy 58.40 17.92 5 19360 360058 90249024
Catarrh 57.30 17.92 19 19346 1615 90607467
Migraine 53.95 17.92 123 19242 190269 90418813
Burns second degree 53.72 17.92 19 19346 1961 90607121
Drug interaction 52.87 17.92 154 19211 276299 90332783
Feeling abnormal 51.83 17.92 112 19253 167123 90441959
Steroid dependence 51.19 17.92 19 19346 2250 90606832
Contraindicated product administered 50.43 17.92 5 19360 320134 90288948
Medication error 48.42 17.92 74 19291 84578 90524504
Wound 47.03 17.92 5 19360 302975 90306107
Accidental overdose 45.52 17.92 42 19323 28231 90580851
Hepatic enzyme increased 44.78 17.92 11 19354 360725 90248357
Bradycardia 44.76 17.92 71 19294 83776 90525306
Therapeutic product effect decreased 44.60 17.92 4 19361 277567 90331515
Swollen tongue 44.54 17.92 52 19313 45904 90563178
Back pain 43.72 17.92 158 19207 317017 90292065
Infection 43.12 17.92 12 19353 362082 90247000
Nightmare 42.41 17.92 36 19329 21689 90587393
Discomfort 39.01 17.92 6 19359 274329 90334753
Dopamine transporter scintigraphy abnormal 38.96 17.92 8 19357 98 90608984
Treatment failure 38.24 17.92 9 19356 303919 90305163
Memory impairment 37.79 17.92 110 19255 197134 90411948
Hyperkalaemia 37.44 17.92 57 19308 64907 90544175
Swelling 36.78 17.92 22 19343 419036 90190046
Muscular weakness 35.59 17.92 111 19254 206555 90402527
Acute kidney injury 35.51 17.92 149 19216 320238 90288844
Serotonin syndrome 33.64 17.92 41 19324 37846 90571236
Rectal haemorrhage 32.27 17.92 61 19304 82683 90526399
Chest pain 31.11 17.92 143 19222 319502 90289580
Therapeutic product effect incomplete 30.59 17.92 3 19362 193893 90415189
Rheumatoid arthritis 30.48 17.92 20 19345 362594 90246488
Tubulointerstitial nephritis 30.28 17.92 32 19333 25311 90583771
Spider naevus 29.51 17.92 7 19358 172 90608910
Asthma 28.86 17.92 8 19357 242152 90366930
Type 2 diabetes mellitus 27.66 17.92 5 19360 203239 90405843
Sinusitis 27.40 17.92 20 19345 343068 90266014
Nasopharyngitis 27.34 17.92 28 19337 407076 90202006
Cardiac murmur 27.31 17.92 26 19339 18168 90590914
Anxiety 26.82 17.92 134 19231 309638 90299444
Musculoskeletal stiffness 26.81 17.92 15 19350 296517 90312565
Polyuria 26.80 17.92 20 19345 10020 90599062
Weight increased 26.67 17.92 30 19335 417897 90191185
Hyperreflexia 26.60 17.92 17 19348 6640 90602442
Parosmia 25.67 17.92 17 19348 7052 90602030
Hyperlactacidaemia 25.57 17.92 14 19351 4122 90604960
IIIrd nerve paresis 25.47 17.92 6 19359 143 90608939
Gingival pain 25.26 17.92 19 19346 9633 90599449
Ultrasound kidney abnormal 25.10 17.92 5 19360 52 90609030
Neonatal anuria 25.10 17.92 5 19360 52 90609030
Exposure during pregnancy 24.70 17.92 10 19355 238400 90370682
Psoriatic arthropathy 24.62 17.92 9 19356 228326 90380756
Injection site pain 24.23 17.92 4 19361 173695 90435387
Ill-defined disorder 24.20 17.92 5 19360 184886 90424196
Drug hypersensitivity 23.80 17.92 39 19326 463570 90145512
Retinal detachment 23.80 17.92 16 19349 6806 90602276
Clonus 23.77 17.92 15 19350 5735 90603347
Skin oedema 23.62 17.92 9 19356 1145 90607937
Malaise 23.47 17.92 209 19156 585777 90023305
Sinus bradycardia 23.15 17.92 23 19342 16929 90592153
Nodal rhythm 22.87 17.92 10 19355 1808 90607274
Blood cholesterol increased 22.76 17.92 8 19357 208004 90401078
Intentional overdose 22.64 17.92 57 19308 93777 90515305
Distributive shock 22.30 17.92 12 19353 3412 90605670
Iodine allergy 22.14 17.92 8 19357 878 90608204
Lethargy 21.53 17.92 44 19321 63095 90545987
Gingival hypertrophy 21.05 17.92 10 19355 2190 90606892
Capillary disorder 21.03 17.92 5 19360 124 90608958
Hypersensitivity 20.86 17.92 41 19324 454636 90154446
Stomatitis 20.68 17.92 17 19348 274681 90334401
Confusional state 20.50 17.92 147 19218 386058 90223024
Syncope 19.89 17.92 68 19297 132595 90476487
Rhinitis 19.62 17.92 19 19346 13553 90595529
Death 19.41 17.92 43 19322 456508 90152574
Inflammation 19.31 17.92 7 19358 178585 90430497
Injury 19.30 17.92 9 19356 197340 90411742
Multiple organ dysfunction syndrome 19.16 17.92 44 19321 68292 90540790
Parkinsonism 19.05 17.92 19 19346 14046 90595036
Incorrect product administration duration 18.95 17.92 22 19343 19300 90589782
Blister 18.92 17.92 16 19349 254982 90354100
Product use issue 18.61 17.92 26 19339 329893 90279189
Product dose omission issue 18.53 17.92 21 19344 291666 90317416
Hypotension 18.52 17.92 126 19239 325271 90283811
Right atrial enlargement 18.23 17.92 5 19360 222 90608860
Eczema 18.21 17.92 37 19328 52833 90556249

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 259.63 17.37 77 21974 1830 42597454
Migraine 250.96 17.37 159 21892 25255 42574029
Tinnitus 244.05 17.37 164 21887 28774 42570510
Palmoplantar keratoderma 238.57 17.37 75 21976 2179 42597105
Tension headache 230.78 17.37 81 21970 3333 42595951
Pruritus genital 226.95 17.37 75 21976 2564 42596720
Sleep terror 219.35 17.37 75 21976 2851 42596433
Atrial tachycardia 201.09 17.37 77 21974 4063 42595221
Carotid artery occlusion 200.12 17.37 77 21974 4117 42595167
Facial pain 198.95 17.37 77 21974 4183 42595101
Palpitations 195.09 17.37 181 21870 50616 42548668
Anosmia 184.43 17.37 77 21974 5099 42594185
Burns second degree 181.96 17.37 80 21971 6016 42593268
Catarrh 180.11 17.37 79 21972 5907 42593377
Gingival pain 177.29 17.37 87 21964 8407 42590877
Immunisation 172.14 17.37 51 22000 1207 42598077
Lip swelling 170.29 17.37 112 21939 18941 42580343
Steroid dependence 165.10 17.37 77 21974 6645 42592639
Hypopnoea 162.32 17.37 80 21971 7802 42591482
Parosmia 161.19 17.37 79 21972 7612 42591672
Pain of skin 157.49 17.37 79 21972 8001 42591283
Systemic lupus erythematosus 149.63 17.37 80 21971 9244 42590040
Angioedema 149.01 17.37 144 21907 42333 42556951
Swollen tongue 134.25 17.37 101 21950 21130 42578154
Cardiac murmur 133.76 17.37 83 21968 12692 42586592
Rhinitis 133.53 17.37 81 21970 11896 42587388
Eye pruritus 131.93 17.37 79 21972 11333 42587951
Pericarditis 127.39 17.37 82 21969 13362 42585922
Muscle twitching 124.51 17.37 77 21974 11703 42587581
Abdominal discomfort 124.36 17.37 173 21878 75082 42524202
Subarachnoid haemorrhage 124.28 17.37 83 21968 14389 42584895
Tubulointerstitial nephritis 118.32 17.37 111 21940 31437 42567847
Rash papular 114.28 17.37 73 21978 11738 42587546
Bronchiectasis 112.32 17.37 85 21966 17934 42581350
Impaired work ability 110.26 17.37 72 21979 12019 42587265
Vasculitis 106.40 17.37 83 21968 18311 42580973
Alcohol poisoning 104.98 17.37 59 21992 7515 42591769
Death 101.85 17.37 59 21992 471126 42128158
Blindness 101.57 17.37 80 21971 17898 42581386
Nightmare 101.53 17.37 92 21959 24920 42574364
Accidental overdose 95.49 17.37 94 21957 28236 42571048
Colitis ulcerative 94.14 17.37 90 21961 26085 42573199
Frequent bowel movements 91.35 17.37 81 21970 21326 42577958
Adverse drug reaction 90.33 17.37 104 21947 37330 42561954
Diplopia 88.95 17.37 78 21973 20238 42579046
Intentional product use issue 83.09 17.37 140 21911 71693 42527591
Impaired quality of life 82.05 17.37 64 21987 14113 42585171
Transient ischaemic attack 81.85 17.37 94 21957 33645 42565639
Vertigo 80.49 17.37 94 21957 34253 42565031
Rectal haemorrhage 80.34 17.37 113 21938 49493 42549791
Medication error 79.81 17.37 92 21959 33062 42566222
Alopecia 76.87 17.37 85 21966 29191 42570093
COVID-19 70.51 17.37 173 21878 115775 42483509
Amnesia 70.28 17.37 80 21971 28357 42570927
Ventricular tachycardia 69.76 17.37 82 21969 30078 42569206
Visual impairment 69.49 17.37 98 21953 43015 42556269
Dysgeusia 69.39 17.37 87 21964 34102 42565182
Dry skin 69.37 17.37 104 21947 48234 42551050
Disturbance in attention 68.74 17.37 81 21970 29785 42569499
Eczema 64.85 17.37 84 21967 34002 42565282
Cognitive disorder 61.59 17.37 82 21969 34090 42565194
Dizziness 59.67 17.37 271 21780 248983 42350301
Drug ineffective 56.46 17.37 155 21896 630042 41969242
Haematochezia 56.09 17.37 105 21946 58331 42540953
Arthritis 55.42 17.37 87 21964 41978 42557306
Muscular weakness 54.40 17.37 128 21923 83370 42515914
Febrile neutropenia 53.37 17.37 15 22036 185688 42413596
Hallucination 52.31 17.37 101 21950 57406 42541878
Myocardial infarction 50.58 17.37 160 21891 123849 42475435
Blood glucose increased 46.93 17.37 112 21939 73587 42525697
Stress 46.93 17.37 83 21968 44129 42555155
Memory impairment 46.65 17.37 89 21962 50133 42549151
Feeling abnormal 44.38 17.37 106 21945 69680 42529604
Pain 44.27 17.37 246 21805 244602 42354682
Heart rate increased 44.18 17.37 90 21961 53165 42546119
Chest pain 43.78 17.37 165 21886 139365 42459919
Peripheral swelling 41.98 17.37 122 21929 90148 42509136
Product dose omission issue 41.59 17.37 14 22037 154351 42444933
Cerebrovascular accident 41.11 17.37 127 21924 97033 42502251
Loss of personal independence in daily activities 41.09 17.37 84 21967 49732 42549552
Nail bed bleeding 39.30 17.37 13 22038 445 42598839
Confusional state 38.38 17.37 180 21871 167417 42431867
Pneumonia 35.34 17.37 107 21944 422042 42177242
Hyperhidrosis 33.47 17.37 113 21938 90399 42508885
Completed suicide 33.45 17.37 5 22046 96460 42502824
Disease progression 30.87 17.37 18 22033 143638 42455646
Abdominal pain upper 30.42 17.37 103 21948 82506 42516778
Off label use 29.83 17.37 201 21850 638134 41961150
Headache 27.08 17.37 214 21837 239155 42360129
Neutropenia 26.33 17.37 39 22012 199392 42399892
Deep vein thrombosis 24.93 17.37 92 21959 76865 42522419
Thrombocytopenia 24.36 17.37 38 22013 190241 42409043
Intentional product misuse 23.51 17.37 78 21973 61822 42537462
Septic shock 23.50 17.37 9 22042 91663 42507621
Leukopenia 23.47 17.37 5 22046 74741 42524543
Pain in extremity 23.08 17.37 145 21906 150459 42448825
Toxicity to various agents 22.98 17.37 53 21998 229083 42370201
Sepsis 22.60 17.37 43 22008 199291 42399993
Malignant neoplasm progression 21.34 17.37 15 22036 108385 42490899
Hospitalisation 21.33 17.37 6 22045 74324 42524960
Interstitial lung disease 21.32 17.37 7 22044 78455 42520829
Drug abuse 21.29 17.37 14 22037 104757 42494527
Tachycardia 20.55 17.37 105 21946 100982 42498302
Dehydration 20.19 17.37 134 21917 141633 42457651
Injection site pain 20.02 17.37 3 22048 57795 42541489
Daydreaming 20.00 17.37 9 22042 714 42598570
Insomnia 19.46 17.37 116 21935 118137 42481147
Scrotal oedema 19.02 17.37 12 22039 1887 42597397
Product use issue 18.91 17.37 8 22043 76743 42522541
Thrombosis 18.81 17.37 6 22045 68505 42530779
Syncope 18.65 17.37 101 21950 99305 42499979
International normalised ratio increased 18.56 17.37 61 21990 48107 42551177
Liver function test abnormal 18.25 17.37 47 22004 32344 42566940
Treatment failure 18.07 17.37 5 22046 62619 42536665
Orthostatic hypotension 17.89 17.37 45 22006 30525 42568759
Sleep inertia 17.61 17.37 4 22047 31 42599253
Pancytopenia 17.59 17.37 21 22030 117722 42481562
Depression 17.53 17.37 108 21943 111255 42488029

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 585.25 16.48 164 38191 4803 110546141
Palmoplantar keratoderma 563.14 16.48 162 38193 5225 110545719
Pruritus genital 532.55 16.48 162 38193 6360 110544584
Sleep terror 517.66 16.48 159 38196 6451 110544493
Tension headache 490.21 16.48 167 38188 9451 110541493
Carotid artery occlusion 487.19 16.48 166 38189 9399 110541545
Atrial tachycardia 474.20 16.48 161 38194 9017 110541927
Tinnitus 462.01 16.48 278 38077 60262 110490682
Anosmia 429.58 16.48 162 38193 12310 110538634
Facial pain 390.23 16.48 160 38195 15179 110535765
Immunisation 383.66 16.48 107 38248 3076 110547868
Pain of skin 368.12 16.48 166 38189 19863 110531081
Muscle twitching 350 16.48 182 38173 29753 110521191
Lip swelling 341.51 16.48 215 38140 50452 110500492
Vasculitis 335.34 16.48 188 38167 35685 110515259
Subarachnoid haemorrhage 322.86 16.48 172 38183 29530 110521414
Angioedema 302.52 16.48 260 38095 98240 110452704
Eye pruritus 296.15 16.48 168 38187 32607 110518337
Palpitations 277.45 16.48 308 38047 158904 110392040
Blindness 272.20 16.48 165 38190 36194 110514750
Catarrh 255.20 16.48 96 38259 7239 110543705
Burns second degree 253.85 16.48 97 38258 7636 110543308
Diplopia 245.88 16.48 163 38192 41731 110509213
Ventricular tachycardia 244.87 16.48 174 38181 49835 110501109
Hypopnoea 240.31 16.48 104 38251 11276 110539668
Transient ischaemic attack 238.41 16.48 189 38166 63793 110487151
Steroid dependence 234.83 16.48 94 38261 8375 110542569
Hallucination 233.77 16.48 228 38127 101204 110449740
Rash papular 218.72 16.48 130 38225 27509 110523435
Disturbance in attention 215.83 16.48 176 38179 61819 110489125
Gingival pain 208.11 16.48 104 38251 15632 110535312
Migraine 205.96 16.48 275 38080 171377 110379567
Parosmia 200.96 16.48 96 38259 13084 110537860
Cardiac murmur 167.11 16.48 105 38250 24523 110526421
Nightmare 162.60 16.48 123 38232 38740 110512204
Swollen tongue 160.65 16.48 147 38208 60215 110490729
Tubulointerstitial nephritis 155.90 16.48 138 38217 54146 110496798
Myocardial infarction 155.71 16.48 256 38099 191827 110359117
Accidental overdose 155.34 16.48 135 38220 51699 110499245
Rhinitis 155.18 16.48 97 38258 22448 110528496
Dry skin 155.15 16.48 189 38166 107464 110443480
Cognitive disorder 151.79 16.48 169 38186 87342 110463602
COVID-19 147.78 16.48 287 38068 244773 110306171
Blood glucose increased 140.40 16.48 200 38155 132296 110418648
Amnesia 132.71 16.48 173 38182 105235 110445709
Visual impairment 130.94 16.48 195 38160 134233 110416711
Bronchiectasis 125.71 16.48 103 38252 36390 110514554
Alcohol poisoning 123.36 16.48 61 38294 8959 110541985
Impaired work ability 118.06 16.48 87 38268 26332 110524612
Medication error 114.49 16.48 161 38194 105205 110445739
Heart rate increased 114.23 16.48 190 38165 143644 110407300
Rectal haemorrhage 111.25 16.48 170 38185 119663 110431281
Dehydration 111.19 16.48 277 38078 279234 110271710
Hyperhidrosis 109.99 16.48 217 38138 187081 110363863
Dizziness 104.09 16.48 498 37857 697695 109853249
Drug ineffective 101.11 16.48 238 38117 1520302 109030642
Intentional product misuse 100.79 16.48 172 38183 132732 110418212
Impaired quality of life 97.72 16.48 82 38273 29935 110521009
Feeling abnormal 96.16 16.48 201 38154 180510 110370434
Colitis ulcerative 95.85 16.48 126 38229 77237 110473707
Adverse drug reaction 92.73 16.48 146 38209 105413 110445531
Infusion related reaction 91.59 16.48 12 38343 381150 110169794
Frequent bowel movements 89.57 16.48 117 38238 71273 110479671
Tachycardia 89.46 16.48 224 38131 226421 110324523
Eczema 86.87 16.48 116 38239 72177 110478767
Drug intolerance 82.12 16.48 20 38335 406492 110144452
Dysgeusia 80.59 16.48 110 38245 69875 110481069
Muscular weakness 80.28 16.48 228 38127 248240 110302704
Vertigo 73.32 16.48 118 38237 86752 110464192
Death 70.77 16.48 83 38272 698786 109852158
Hyponatraemia 70.56 16.48 200 38155 217453 110333491
Intentional product use issue 70.10 16.48 217 38138 247689 110303255
Maternal exposure during pregnancy 69.13 16.48 5 38350 254878 110296066
Abdominal discomfort 69.06 16.48 295 38060 393563 110157381
Memory impairment 68.81 16.48 186 38169 196758 110354186
Chest pain 67.61 16.48 284 38071 376091 110174853
Arthropathy 64.57 16.48 11 38344 287511 110263433
Hepatic enzyme increased 64.38 16.48 16 38339 320876 110230068
Cerebrovascular accident 64.13 16.48 172 38183 181112 110369832
Therapeutic product effect incomplete 61.83 16.48 4 38351 223801 110327143
Contraindicated product administered 61.62 16.48 7 38348 248260 110302684
Haematochezia 58.53 16.48 126 38229 115398 110435546
Febrile neutropenia 57.63 16.48 19 38336 316748 110234196
Treatment failure 57.23 16.48 13 38342 277221 110273723
Blood creatine increased 56.16 16.48 40 38315 11481 110539463
Confusional state 55.59 16.48 314 38041 468366 110082578
Bradycardia 55.44 16.48 148 38207 155369 110395575
Impaired healing 52.93 16.48 4 38351 196713 110354231
Drug hypersensitivity 51.43 16.48 49 38306 454041 110096903
Product dose omission issue 50.82 16.48 24 38331 321758 110229186
Sinusitis 50.23 16.48 20 38335 296668 110254276
Infection 49.97 16.48 32 38323 362168 110188776
Swelling 49.84 16.48 30 38325 351011 110199933
Back pain 46.94 16.48 253 38102 370743 110180201
Nasopharyngitis 46.50 16.48 41 38314 394320 110156624
Helicobacter infection 45.45 16.48 5 38350 181872 110369072
Pericarditis 45.43 16.48 173 38182 218941 110332003
Therapeutic product effect decreased 43.83 16.48 15 38340 244301 110306643
Hyperkalaemia 43.22 16.48 124 38231 135672 110415272
Stomatitis 42.90 16.48 20 38335 270222 110280722
Wound 42.74 16.48 14 38341 234423 110316521
Stress 42.44 16.48 105 38250 105243 110445701
Fibromyalgia 41.95 16.48 5 38350 170904 110380040
Injection site pain 41.76 16.48 6 38349 177916 110373028
Blood cholesterol increased 41.63 16.48 7 38348 184778 110366166
Exposure during pregnancy 40.84 16.48 5 38350 167419 110383525
Syncope 39.61 16.48 157 38198 202379 110348565
Anxiety 39.43 16.48 229 38126 344849 110206095
Weight increased 39.12 16.48 53 38302 419591 110131353
Asthma 37.51 16.48 20 38335 250271 110300673
Deep vein thrombosis 37.25 16.48 120 38235 139767 110411177
Discomfort 37.12 16.48 14 38341 214693 110336251
Nail bed bleeding 36.43 16.48 13 38342 843 110550101
Ill-defined disorder 35.20 16.48 6 38349 156847 110394097
Product use issue 34.85 16.48 34 38321 311661 110239283
Scrotal oedema 34.30 16.48 15 38340 1666 110549278
Off label use 32.73 16.48 348 38007 1499837 109051107
Liver function test abnormal 32.41 16.48 73 38282 68877 110482067
Hypersensitivity 31.94 16.48 57 38298 403941 110147003
Bursitis 31.39 16.48 4 38351 129914 110421030
Joint range of motion decreased 31.34 16.48 3 38352 121829 110429115
Musculoskeletal stiffness 30.73 16.48 31 38324 279791 110271153
Gingival hypertrophy 30.72 16.48 19 38336 4312 110546632
Insomnia 30.58 16.48 222 38133 360368 110190576
Blister 30.12 16.48 21 38334 227355 110323589
Type 2 diabetes mellitus 29.90 16.48 12 38343 177220 110373724
Neutropenia 29.48 16.48 53 38302 374567 110176377
Peripheral swelling 29.40 16.48 240 38115 403794 110147150
Disease progression 29.20 16.48 25 38330 244009 110306935
Psoriatic arthropathy 29.07 16.48 16 38339 196745 110354199
Pulmonary embolism 28.97 16.48 149 38206 214325 110336619
Alopecia 28.91 16.48 221 38134 364532 110186412
Completed suicide 28.79 16.48 25 38330 242356 110308588
Rheumatoid arthritis 28.76 16.48 37 38318 299576 110251368
Abdominal pain upper 28.50 16.48 213 38142 348898 110202046
Musculoskeletal pain 28.35 16.48 14 38341 183009 110367935
Hospitalisation 26.88 16.48 8 38347 142485 110408459
Spider naevus 26.83 16.48 7 38348 155 110550789
Dyspnoea 25.44 16.48 531 37824 1106341 109444603
General physical health deterioration 25.41 16.48 70 38285 425225 110125719
Injury 25.35 16.48 15 38340 177250 110373694
Pneumonia 24.90 16.48 190 38165 876524 109674420
Adverse event 24.78 16.48 4 38351 108805 110442139
Neuropathy peripheral 24.49 16.48 16 38339 179261 110371683
Septic shock 24.47 16.48 12 38343 157516 110393428
Road traffic accident 24.34 16.48 4 38351 107394 110443550
Thrombocytopenia 24.31 16.48 53 38302 348832 110202112
Gastrointestinal disorder 24.14 16.48 29 38326 241923 110309021
Liver disorder 23.39 16.48 10 38345 142233 110408711
Wound infection 23.23 16.48 3 38352 96462 110454482
Mucosal inflammation 23.13 16.48 3 38352 96138 110454806
Hypertension 22.93 16.48 95 38260 509989 110040955
Drug ineffective for unapproved indication 22.93 16.48 4 38351 102834 110448110
International normalised ratio increased 22.70 16.48 74 38281 86698 110464246
Orthostatic hypotension 22.54 16.48 62 38293 66187 110484757
Therapeutic response decreased 20.98 16.48 4 38351 96495 110454449
Malignant neoplasm progression 20.73 16.48 18 38337 174549 110376395
Malaise 20.51 16.48 337 38018 671482 109879462
Lethargy 20.30 16.48 75 38280 93501 110457443
Pyrexia 20.30 16.48 430 37925 897835 109653109
Somnolence 20.19 16.48 174 38181 297275 110253669
Pruritus 20.14 16.48 298 38057 581262 109969682
Dyspepsia 20.01 16.48 22 38333 190943 110360001
Loss of personal independence in daily activities 19.40 16.48 103 38252 149917 110401027
Contusion 19.27 16.48 32 38323 233329 110317615
Daydreaming 19.07 16.48 9 38346 1193 110549751
Illness 18.75 16.48 3 38352 82168 110468776
Injection site erythema 18.29 16.48 5 38350 94171 110456773
Sleep inertia 18.20 16.48 4 38351 41 110550903
Penile oedema 18.02 16.48 6 38349 316 110550628
Sciatica 17.77 16.48 5 38350 92394 110458550
Polyuria 17.63 16.48 26 38329 17712 110533232
Sleep disorder 17.58 16.48 26 38329 198618 110352326
Skin oedema 17.38 16.48 10 38345 1989 110548955
Hypercholesterolaemia 17.31 16.48 5 38350 90832 110460112
Thrombosis 17.30 16.48 8 38347 108654 110442290
Faeces discoloured 17.15 16.48 37 38318 33911 110517033
Nodal rhythm 16.95 16.48 12 38343 3411 110547533
Therapy non-responder 16.62 16.48 18 38337 157289 110393655
Lung disorder 16.49 16.48 23 38332 180024 110370920

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07FB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C08CA02 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C09BB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
FDA CS M0006414 Dihydropyridines
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175421 Dihydropyridine Calcium Channel Blocker
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:38215 calcium channel blocker
CHEBI has role CHEBI:145947 antiatherosclerotic agent

Related Drugs by ATC class:

C07FB Beta blocking agents and calcium channel blockers 6 drugs
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C08CA Dihydropyridine derivatives 17 drugs
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C09BB ACE inhibitors and calcium channel blockers 13 drugs
amlodipinebenazeprildelaprilenalaprillercanidipinelisinoprilmanidipinenitrendipineperindoprilramipriltrandolaprilverapamil show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Prinzmetal angina off-label use 87343002
Angina pectoris off-label use 194828000
Raynaud's phenomenon off-label use 266261006
Hyperkalemia contraindication 14140009
Myocardial infarction contraindication 22298006 DOID:5844
Acute cerebrovascular insufficiency contraindication 29322000
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Aortic valve stenosis contraindication 60573004 DOID:1712
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Peripheral edema contraindication 271809000
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Hemodialysis with High-Flux Membrane contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.68 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER WOMBAT-PK CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel BLOCKER WOMBAT-PK CHEMBL
Bile acid receptor Nuclear hormone receptor IC50 5.30 CHEMBL
Aldehyde oxidase Enzyme IC50 6.52 WOMBAT-PK
Adenosine receptor A3 GPCR Ki 6.22 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 5.34 DRUG MATRIX
Cystic fibrosis transmembrane conductance regulator Ion channel ACTIVATOR Ki 8.40 IUPHAR
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.43 CHEMBL
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 5.17 WOMBAT-PK

External reference:

IDSource
4020159 VUID
N0000148116 NUI
D00319 KEGG_DRUG
4020159 VANDF
C0015772 UMLSCUI
CHEBI:585948 CHEBI
225 PDB_CHEM_ID
CHEMBL1480 ChEMBL_ID
DB01023 DRUGBANK_ID
D015736 MESH_DESCRIPTOR_UI
3333 PUBCHEM_CID
4190 IUPHAR_LIGAND_ID
4877 INN_ID
OL961R6O2C UNII
4316 RXNORM
4716 MMSL
62563 MMSL
d00231 MMSL
003602 NDDF
108535009 SNOMEDCT_US
386863007 SNOMEDCT_US
OL961R6O2C INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 0603-3581 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 22 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 0603-3582 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 22 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 0603-3583 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 22 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 13668-132 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 17 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 13668-133 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 17 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 13668-134 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 17 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-048 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-048 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-049 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-049 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-050 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-050 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 10 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 50090-1124 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 17 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 50090-2421 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 24 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 50090-4808 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 19 sections
Felodipine Human Prescription Drug Label 1 50090-5870 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 19 sections
Felopdipine HUMAN PRESCRIPTION DRUG LABEL 1 50090-7206 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 24 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 51407-087 TABLET, FILM COATED 2.50 mg ORAL ANDA 21 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 51407-088 TABLET, FILM COATED 5 mg ORAL ANDA 21 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 51407-089 TABLET, FILM COATED 10 mg ORAL ANDA 21 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 54868-0823 TABLET, FILM COATED 2.50 mg ORAL ANDA 24 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 54868-0826 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 24 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5197 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 24 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 55648-411 TABLET, FILM COATED, EXTENDED RELEASE 2.50 mg ORAL ANDA 11 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 55648-412 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 11 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 55648-414 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 11 sections
Felodipine Human Prescription Drug Label 1 57237-108 TABLET, FILM COATED, EXTENDED RELEASE 2.50 mg ORAL ANDA 19 sections
Felodipine Human Prescription Drug Label 1 57237-109 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 19 sections
Felodipine Human Prescription Drug Label 1 57237-110 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 19 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 61442-431 TABLET, FILM COATED 2.50 mg ORAL ANDA 21 sections