delapril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 798 83435-66-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CV-3317
  • delapril
  • alindapril
  • indalapril
  • Molecular weight: 452.55
  • Formula: C26H32N2O5
  • CLOGP: 2.45
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -4.93
  • ROTB: 12

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA12 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA12 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
ATC C09BB12 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.12 acidic
pKa2 5.46 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR Ki 9.97 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Angiotensin-converting enzyme Enzyme IC50 6.92 SCIENTIFIC LITERATURE

External reference:

IDSource
50A464U6E7 UNII
83398-08-7 SECONDARY_CAS_RN
698093003 SNOMEDCT_US
008159 NDDF
CHEMBL589583 ChEMBL_ID
CHEBI:135735 CHEBI
5797 INN_ID
C047759 MESH_SUPPLEMENTAL_RECORD_UI
DB13312 DRUGBANK_ID
5362116 PUBCHEM_CID

Pharmaceutical products:

None