cilnidipine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 642 132203-70-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • FRC-8653
  • cilnidipine
  • cinaldipine
  • cinalong
has excitatory & inhibitory action on the Ca+ channels in the rabbit basilar artery; structure given in first source; RN given is for (+-) isomer
  • Molecular weight: 492.53
  • Formula: C27H28N2O7
  • CLOGP: 5.54
  • LIPINSKI: 1
  • HAC: 9
  • HDO: 1
  • TPSA: 117
  • ALOGS: -5.94
  • ROTB: 12

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Renal impairment 55.76 29.75 28 916 74344 46610774
Hepatic function abnormal 48.06 29.75 20 924 34401 46650717

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral infarction 55.69 29.67 27 1492 26346 29924613
Hyperkinetic heart syndrome 48.72 29.67 8 1511 124 29950835
Interstitial lung disease 44.17 29.67 31 1488 60166 29890793
Hepatic function abnormal 43.94 29.67 27 1492 41918 29909041
Renal impairment 36.98 29.67 32 1487 84152 29866807
Echocardiogram abnormal 35.04 29.67 8 1511 724 29950235
Stress cardiomyopathy 33.78 29.67 9 1510 1540 29949419

Pharmacologic Action:

SourceCodeDescription
ATC C08CA14 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:35554 cardiovascular drugs
CHEBI has role CHEBI:35674 antihypertensive
CHEBI has role CHEBI:38215 calcium channel blockers

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.67 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Voltage-dependent N-type calcium channel subunit alpha-1B Unclassified BLOCKER IC50 6.70 IUPHAR

External reference:

IDSource
D01173 KEGG_DRUG
C0378675 UMLSCUI
CHEBI:31399 CHEBI
CHEMBL452076 ChEMBL_ID
DB09232 DRUGBANK_ID
C065927 MESH_SUPPLEMENTAL_RECORD_UI
5282138 PUBCHEM_CID
7767 IUPHAR_LIGAND_ID
6880 INN_ID
97T5AZ1JIP UNII
010899 NDDF

Pharmaceutical products:

None