Stem definition | Drug id | CAS RN |
---|---|---|
beta-adrenoreceptor antagonists | 255 | 29122-68-7 |
Dose | Unit | Route |
---|---|---|
75 | mg | O |
75 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 26.50 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 94 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 12.50 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 56 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.95 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.94 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 6.10 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 19, 1981 | FDA | ALVOGEN IPCO SARL |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Bradycardia | 650.85 | 9.69 | 834 | 149487 | 72393 | 63266308 |
Pemphigus | 403.91 | 9.69 | 6 | 150315 | 183720 | 63154981 |
Systemic lupus erythematosus | 340.06 | 9.69 | 46 | 150275 | 208872 | 63129829 |
Hand deformity | 317.86 | 9.69 | 14 | 150307 | 159443 | 63179258 |
Maternal exposure during pregnancy | 286.21 | 9.69 | 83 | 150238 | 219979 | 63118722 |
Glossodynia | 284.95 | 9.69 | 42 | 150279 | 178834 | 63159867 |
Off label use | 255.23 | 9.69 | 787 | 149534 | 673675 | 62665026 |
Pericarditis | 245.38 | 9.69 | 17 | 150304 | 131562 | 63207139 |
Wound | 215.13 | 9.69 | 60 | 150261 | 163203 | 63175498 |
Hypotension | 208.44 | 9.69 | 1228 | 149093 | 271376 | 63067325 |
Cardiac failure congestive | 204.58 | 9.69 | 580 | 149741 | 91853 | 63246848 |
Drug ineffective | 204.38 | 9.69 | 1545 | 148776 | 1043220 | 62295481 |
Myocardial infarction | 180.79 | 9.69 | 584 | 149737 | 99309 | 63239392 |
Duodenal ulcer perforation | 172.61 | 9.69 | 8 | 150313 | 87201 | 63251500 |
Discomfort | 168.79 | 9.69 | 93 | 150228 | 167281 | 63171420 |
Cerebrovascular accident | 168.62 | 9.69 | 601 | 149720 | 107423 | 63231278 |
Sinus bradycardia | 162.16 | 9.69 | 186 | 150135 | 14365 | 63324336 |
Drug intolerance | 148.77 | 9.69 | 318 | 150003 | 308343 | 63030358 |
Treatment failure | 146.48 | 9.69 | 153 | 150168 | 198890 | 63139811 |
Contraindicated product administered | 144.27 | 9.69 | 182 | 150139 | 217466 | 63121235 |
Folliculitis | 140.63 | 9.69 | 6 | 150315 | 70311 | 63268390 |
Coronary artery disease | 139.24 | 9.69 | 264 | 150057 | 32113 | 63306588 |
Alopecia | 136.52 | 9.69 | 381 | 149940 | 337155 | 63001546 |
Syncope | 135.41 | 9.69 | 594 | 149727 | 116791 | 63221910 |
Atrial fibrillation | 121.69 | 9.69 | 573 | 149748 | 116063 | 63222638 |
Muscle injury | 120.19 | 9.69 | 9 | 150312 | 65336 | 63273365 |
Drug interaction | 117.53 | 9.69 | 936 | 149385 | 228195 | 63110506 |
Hyponatraemia | 116.21 | 9.69 | 549 | 149772 | 111351 | 63227350 |
Infusion related reaction | 115.72 | 9.69 | 256 | 150065 | 245265 | 63093436 |
Electric shock | 114.55 | 9.69 | 58 | 150263 | 1262 | 63337439 |
Swelling | 113.41 | 9.69 | 308 | 150013 | 275070 | 63063631 |
Synovitis | 113.06 | 9.69 | 167 | 150154 | 186751 | 63151950 |
Exposure during pregnancy | 112.81 | 9.69 | 121 | 150200 | 155426 | 63183275 |
Abdominal discomfort | 110.14 | 9.69 | 390 | 149931 | 320495 | 63018206 |
Infection | 107.13 | 9.69 | 240 | 150081 | 228933 | 63109768 |
Product use in unapproved indication | 106.36 | 9.69 | 162 | 150159 | 178918 | 63159783 |
Therapeutic product effect incomplete | 105.16 | 9.69 | 85 | 150236 | 124971 | 63213730 |
Acute kidney injury | 104.98 | 9.69 | 1018 | 149303 | 262397 | 63076304 |
Arthropathy | 104.84 | 9.69 | 252 | 150069 | 234540 | 63104161 |
Intentional product use issue | 103.76 | 9.69 | 90 | 150231 | 127802 | 63210899 |
Sleep disorder due to general medical condition, insomnia type | 102.64 | 9.69 | 5 | 150316 | 52212 | 63286489 |
Nasopharyngitis | 101.25 | 9.69 | 289 | 150032 | 253968 | 63084733 |
Hypertensive crisis | 99.50 | 9.69 | 150 | 150171 | 15136 | 63323565 |
Hepatic enzyme increased | 97.77 | 9.69 | 208 | 150113 | 202120 | 63136581 |
Therapeutic product effect decreased | 96.38 | 9.69 | 195 | 150126 | 192992 | 63145709 |
Hypersensitivity | 93.70 | 9.69 | 366 | 149955 | 292319 | 63046382 |
Dehydration | 90.94 | 9.69 | 712 | 149609 | 172642 | 63166059 |
General physical health deterioration | 89.23 | 9.69 | 217 | 150104 | 201185 | 63137516 |
Blister | 82.42 | 9.69 | 112 | 150209 | 129702 | 63208999 |
Intervertebral discitis | 79.66 | 9.69 | 64 | 150257 | 3164 | 63335537 |
Shock | 79.12 | 9.69 | 173 | 150148 | 23290 | 63315411 |
Heart rate decreased | 78.45 | 9.69 | 262 | 150059 | 45298 | 63293403 |
Dizziness | 78.03 | 9.69 | 1440 | 148881 | 428485 | 62910216 |
Rheumatoid factor positive | 77.91 | 9.69 | 52 | 150269 | 84354 | 63254347 |
Renal failure | 77.78 | 9.69 | 511 | 149810 | 117141 | 63221560 |
Haematocrit decreased | 77.55 | 9.69 | 237 | 150084 | 39103 | 63299598 |
Product use issue | 76.95 | 9.69 | 266 | 150055 | 220254 | 63118447 |
Fall | 70.08 | 9.69 | 1311 | 149010 | 391023 | 62947678 |
Pyrexia | 66.51 | 9.69 | 753 | 149568 | 469725 | 62868976 |
Ill-defined disorder | 63.35 | 9.69 | 60 | 150261 | 81695 | 63257006 |
Angina unstable | 63.24 | 9.69 | 81 | 150240 | 7014 | 63331687 |
Hyperkalaemia | 62.99 | 9.69 | 275 | 150046 | 53928 | 63284773 |
Neovascularisation | 62.42 | 9.69 | 37 | 150284 | 1108 | 63337593 |
Acute myocardial infarction | 61.89 | 9.69 | 192 | 150129 | 31932 | 63306769 |
Stomatitis | 61.79 | 9.69 | 149 | 150172 | 138576 | 63200125 |
Gastrointestinal disorder | 61.64 | 9.69 | 137 | 150184 | 131102 | 63207599 |
Device expulsion | 60.96 | 9.69 | 6 | 150315 | 34916 | 63303785 |
Sinusitis | 60.06 | 9.69 | 304 | 150017 | 226349 | 63112352 |
Product complaint | 58.25 | 9.69 | 107 | 150214 | 12702 | 63325999 |
Coordination abnormal | 57.60 | 9.69 | 111 | 150210 | 13662 | 63325039 |
Demyelination | 57.01 | 9.69 | 76 | 150245 | 6844 | 63331857 |
Pain | 56.74 | 9.69 | 1329 | 148992 | 739299 | 62599402 |
Blood pressure increased | 56.66 | 9.69 | 610 | 149711 | 161452 | 63177249 |
Post-traumatic stress disorder | 56.62 | 9.69 | 66 | 150255 | 5185 | 63333516 |
Completed suicide | 56.47 | 9.69 | 560 | 149761 | 145113 | 63193588 |
Loss of employment | 56.46 | 9.69 | 45 | 150276 | 2199 | 63336502 |
Helicobacter infection | 55.96 | 9.69 | 83 | 150238 | 92702 | 63245999 |
Blood urea increased | 54.90 | 9.69 | 162 | 150159 | 26217 | 63312484 |
Irritable bowel syndrome | 54.45 | 9.69 | 69 | 150252 | 82343 | 63256358 |
Blood creatinine increased | 52.95 | 9.69 | 373 | 149948 | 87471 | 63251230 |
Temperature intolerance | 52.80 | 9.69 | 84 | 150237 | 8880 | 63329821 |
International normalised ratio increased | 52.02 | 9.69 | 233 | 150088 | 46192 | 63292509 |
Lower respiratory tract infection | 51.43 | 9.69 | 152 | 150169 | 132155 | 63206546 |
Liver injury | 51.02 | 9.69 | 41 | 150280 | 60479 | 63278222 |
Asthma | 50.71 | 9.69 | 145 | 150176 | 127416 | 63211285 |
Haemoglobin decreased | 50.57 | 9.69 | 547 | 149774 | 144938 | 63193763 |
Red blood cell count decreased | 50.15 | 9.69 | 210 | 150111 | 40435 | 63298266 |
Blood glucose increased | 49.52 | 9.69 | 354 | 149967 | 83402 | 63255299 |
Live birth | 48.67 | 9.69 | 3 | 150318 | 25627 | 63313074 |
Psoriatic arthropathy | 48.55 | 9.69 | 89 | 150232 | 91431 | 63247270 |
Atrioventricular block first degree | 48.23 | 9.69 | 72 | 150249 | 7201 | 63331500 |
Rash | 47.00 | 9.69 | 992 | 149329 | 559879 | 62778822 |
Overdose | 46.85 | 9.69 | 447 | 149874 | 114631 | 63224070 |
Joint swelling | 45.61 | 9.69 | 526 | 149795 | 327140 | 63011561 |
Asthenia | 44.79 | 9.69 | 1207 | 149114 | 382397 | 62956304 |
Chest pain | 44.67 | 9.69 | 739 | 149582 | 215220 | 63123481 |
Frustration tolerance decreased | 44.67 | 9.69 | 68 | 150253 | 6920 | 63331781 |
Blood pressure inadequately controlled | 44.63 | 9.69 | 57 | 150264 | 4921 | 63333780 |
Transient ischaemic attack | 44.21 | 9.69 | 192 | 150129 | 37561 | 63301140 |
Blood pressure systolic increased | 43.09 | 9.69 | 224 | 150097 | 47173 | 63291528 |
Loss of consciousness | 42.85 | 9.69 | 448 | 149873 | 117673 | 63221028 |
Sinus arrest | 42.57 | 9.69 | 36 | 150285 | 1913 | 63336788 |
Hip arthroplasty | 41.79 | 9.69 | 31 | 150290 | 47615 | 63291086 |
Coronary arterial stent insertion | 39.98 | 9.69 | 41 | 150280 | 2788 | 63335913 |
Feeling abnormal | 39.34 | 9.69 | 530 | 149791 | 147862 | 63190839 |
Blood glucose decreased | 39.23 | 9.69 | 124 | 150197 | 20828 | 63317873 |
Myalgia | 39.12 | 9.69 | 524 | 149797 | 146005 | 63192696 |
Exposure via ingestion | 39.03 | 9.69 | 41 | 150280 | 2868 | 63335833 |
Mobility decreased | 39.03 | 9.69 | 151 | 150170 | 121008 | 63217693 |
Condition aggravated | 38.94 | 9.69 | 694 | 149627 | 401523 | 62937178 |
Hyperhidrosis | 38.65 | 9.69 | 408 | 149913 | 107428 | 63231273 |
Knee arthroplasty | 38.35 | 9.69 | 43 | 150278 | 54163 | 63284538 |
Palpitations | 38.25 | 9.69 | 422 | 149899 | 112348 | 63226353 |
Drug resistance | 37.38 | 9.69 | 5 | 150316 | 22928 | 63315773 |
Prescribed overdose | 37.36 | 9.69 | 17 | 150304 | 34136 | 63304565 |
Lactic acidosis | 36.94 | 9.69 | 184 | 150137 | 38103 | 63300598 |
Hypokalaemia | 36.85 | 9.69 | 392 | 149929 | 103412 | 63235289 |
Lipase increased | 36.85 | 9.69 | 76 | 150245 | 9824 | 63328877 |
Ventricular hypertrophy | 36.73 | 9.69 | 43 | 150278 | 3393 | 63335308 |
Fibromyalgia | 36.09 | 9.69 | 86 | 150235 | 80334 | 63258367 |
Rectal polyp | 35.87 | 9.69 | 27 | 150294 | 1212 | 63337489 |
COVID-19 | 35.13 | 9.69 | 143 | 150178 | 112960 | 63225741 |
Oedema peripheral | 35.03 | 9.69 | 637 | 149684 | 188874 | 63149827 |
Wheezing | 34.89 | 9.69 | 113 | 150208 | 95482 | 63243219 |
Premature delivery | 34.84 | 9.69 | 14 | 150307 | 30267 | 63308434 |
Angina pectoris | 34.48 | 9.69 | 152 | 150169 | 29926 | 63308775 |
Post cholecystectomy syndrome | 34.37 | 9.69 | 18 | 150303 | 421 | 63338280 |
Pregnancy | 33.57 | 9.69 | 23 | 150298 | 36813 | 63301888 |
Hyperlipidaemia | 33.20 | 9.69 | 112 | 150209 | 19459 | 63319242 |
Diabetes mellitus | 33.05 | 9.69 | 236 | 150085 | 55574 | 63283127 |
Anuria | 33.01 | 9.69 | 84 | 150237 | 12467 | 63326234 |
Febrile neutropenia | 33.00 | 9.69 | 156 | 150165 | 118293 | 63220408 |
Femur fracture | 32.36 | 9.69 | 189 | 150132 | 41567 | 63297134 |
Depression | 32.06 | 9.69 | 648 | 149673 | 195844 | 63142857 |
Rhabdomyolysis | 30.93 | 9.69 | 194 | 150127 | 43757 | 63294944 |
Melaena | 30.77 | 9.69 | 148 | 150173 | 30217 | 63308484 |
Myelosuppression | 30.66 | 9.69 | 9 | 150312 | 23694 | 63315007 |
Vulvovaginal burning sensation | 30.60 | 9.69 | 31 | 150290 | 2078 | 63336623 |
Blood immunoglobulin A increased | 29.54 | 9.69 | 20 | 150301 | 758 | 63337943 |
Coronary artery occlusion | 29.46 | 9.69 | 62 | 150259 | 8129 | 63330572 |
Hospitalisation | 29.39 | 9.69 | 103 | 150218 | 84978 | 63253723 |
Arteriosclerosis | 29.26 | 9.69 | 70 | 150251 | 9996 | 63328705 |
Atrioventricular block complete | 29.15 | 9.69 | 62 | 150259 | 8189 | 63330512 |
Haemodialysis | 29.07 | 9.69 | 65 | 150256 | 8882 | 63329819 |
Aspartate aminotransferase | 28.85 | 9.69 | 16 | 150305 | 421 | 63338280 |
Malignant neoplasm progression | 28.64 | 9.69 | 99 | 150222 | 82022 | 63256679 |
Ulcer | 28.47 | 9.69 | 130 | 150191 | 25977 | 63312724 |
Device dislocation | 27.80 | 9.69 | 13 | 150308 | 25692 | 63313009 |
Fear of eating | 27.67 | 9.69 | 15 | 150306 | 377 | 63338324 |
Poisoning | 27.43 | 9.69 | 83 | 150238 | 13617 | 63325084 |
Abortion spontaneous | 26.75 | 9.69 | 44 | 150277 | 47151 | 63291550 |
Musculoskeletal stiffness | 26.58 | 9.69 | 294 | 150027 | 184324 | 63154377 |
Foetal exposure during pregnancy | 26.51 | 9.69 | 22 | 150299 | 31940 | 63306761 |
Drug abuse | 26.26 | 9.69 | 86 | 150235 | 72432 | 63266269 |
Multiple fractures | 26.21 | 9.69 | 61 | 150260 | 8557 | 63330144 |
Blood pressure decreased | 25.68 | 9.69 | 251 | 150070 | 64771 | 63273930 |
Cardiomegaly | 24.93 | 9.69 | 95 | 150226 | 17519 | 63321182 |
Dilatation atrial | 24.84 | 9.69 | 27 | 150294 | 1964 | 63336737 |
Duodenal ulcer | 24.81 | 9.69 | 56 | 150265 | 7700 | 63331001 |
Arrhythmia | 24.78 | 9.69 | 165 | 150156 | 37975 | 63300726 |
Metabolic acidosis | 24.64 | 9.69 | 187 | 150134 | 44882 | 63293819 |
Paradoxical drug reaction | 24.58 | 9.69 | 39 | 150282 | 4113 | 63334588 |
Change of bowel habit | 24.38 | 9.69 | 28 | 150293 | 2165 | 63336536 |
Atrioventricular block | 24.22 | 9.69 | 55 | 150266 | 7592 | 63331109 |
Vision blurred | 24.21 | 9.69 | 328 | 149993 | 91596 | 63247105 |
Rhinalgia | 24.11 | 9.69 | 24 | 150297 | 1575 | 63337126 |
Incorrect route of product administration | 23.89 | 9.69 | 18 | 150303 | 27434 | 63311267 |
Balance disorder | 23.81 | 9.69 | 305 | 150016 | 84117 | 63254584 |
Hypoglycaemia | 23.78 | 9.69 | 232 | 150089 | 59833 | 63278868 |
Blood pressure immeasurable | 23.37 | 9.69 | 21 | 150300 | 1211 | 63337490 |
Autoimmune disorder | 23.19 | 9.69 | 6 | 150315 | 17171 | 63321530 |
Rectosigmoid cancer | 23.11 | 9.69 | 10 | 150311 | 150 | 63338551 |
Product dose omission issue | 23.04 | 9.69 | 403 | 149918 | 233910 | 63104791 |
Blood sodium decreased | 23.00 | 9.69 | 116 | 150205 | 24136 | 63314565 |
Type 2 diabetes mellitus | 22.95 | 9.69 | 76 | 150245 | 63792 | 63274909 |
Vulvovaginal pruritus | 22.80 | 9.69 | 33 | 150288 | 3210 | 63335491 |
Granulocyte count increased | 22.75 | 9.69 | 18 | 150303 | 870 | 63337831 |
Progressive multifocal leukoencephalopathy | 22.68 | 9.69 | 75 | 150246 | 12896 | 63325805 |
Glomerular filtration rate increased | 22.58 | 9.69 | 18 | 150303 | 880 | 63337821 |
Impaired quality of life | 22.48 | 9.69 | 3 | 150318 | 13780 | 63324921 |
Nodal rhythm | 22.38 | 9.69 | 24 | 150297 | 1719 | 63336982 |
Death | 22.22 | 9.69 | 696 | 149625 | 373685 | 62965016 |
Rheumatoid arthritis | 22.04 | 9.69 | 446 | 149875 | 253373 | 63085328 |
Lethargy | 22.02 | 9.69 | 216 | 150105 | 55791 | 63282910 |
Confusion postoperative | 21.91 | 9.69 | 11 | 150310 | 235 | 63338466 |
Drug dispensed to wrong patient | 21.84 | 9.69 | 12 | 150309 | 310 | 63338391 |
Monoclonal B-cell lymphocytosis | 21.68 | 9.69 | 7 | 150314 | 43 | 63338658 |
Phaeochromocytoma crisis | 21.61 | 9.69 | 11 | 150310 | 242 | 63338459 |
Inappropriate antidiuretic hormone secretion | 21.56 | 9.69 | 83 | 150238 | 15379 | 63323322 |
Angioedema | 21.37 | 9.69 | 190 | 150131 | 47775 | 63290926 |
Phaeochromocytoma | 21.29 | 9.69 | 14 | 150307 | 505 | 63338196 |
Hypertension | 20.91 | 9.69 | 834 | 149487 | 278469 | 63060232 |
Hepatic steatosis | 20.87 | 9.69 | 128 | 150193 | 28641 | 63310060 |
Fear | 20.66 | 9.69 | 83 | 150238 | 15683 | 63323018 |
Blood potassium increased | 20.59 | 9.69 | 92 | 150229 | 18217 | 63320484 |
Ventricular fibrillation | 20.20 | 9.69 | 68 | 150253 | 11799 | 63326902 |
BRASH syndrome | 20.09 | 9.69 | 13 | 150308 | 456 | 63338245 |
Jaundice | 19.89 | 9.69 | 128 | 150193 | 29123 | 63309578 |
Sinus node dysfunction | 19.89 | 9.69 | 38 | 150283 | 4647 | 63334054 |
Pulmonary oedema | 19.83 | 9.69 | 208 | 150113 | 54665 | 63284036 |
Lacunar infarction | 19.68 | 9.69 | 31 | 150290 | 3249 | 63335452 |
Pancreatitis | 19.68 | 9.69 | 190 | 150131 | 48865 | 63289836 |
Myocardial ischaemia | 19.57 | 9.69 | 71 | 150250 | 12788 | 63325913 |
Coronary artery bypass | 19.49 | 9.69 | 26 | 150295 | 2343 | 63336358 |
Skull fracture | 19.47 | 9.69 | 18 | 150303 | 1077 | 63337624 |
Dry mouth | 19.36 | 9.69 | 275 | 150046 | 77588 | 63261113 |
Bronchiectasis | 19.34 | 9.69 | 7 | 150314 | 16135 | 63322566 |
Anxiety | 19.28 | 9.69 | 662 | 149659 | 216879 | 63121822 |
Product substitution issue | 19.22 | 9.69 | 82 | 150239 | 15914 | 63322787 |
Bone erosion | 19.10 | 9.69 | 9 | 150312 | 17708 | 63320993 |
Disease progression | 19.08 | 9.69 | 192 | 150129 | 122566 | 63216135 |
Vitamin B12 increased | 19.02 | 9.69 | 18 | 150303 | 1110 | 63337591 |
Neutrophil count decreased | 19.00 | 9.69 | 69 | 150252 | 56337 | 63282364 |
Laryngotracheal oedema | 18.99 | 9.69 | 6 | 150315 | 34 | 63338667 |
Emotional distress | 18.90 | 9.69 | 137 | 150184 | 32412 | 63306289 |
Throat irritation | 18.81 | 9.69 | 153 | 150168 | 37494 | 63301207 |
Cardiogenic shock | 18.60 | 9.69 | 88 | 150233 | 17844 | 63320857 |
Disability | 18.28 | 9.69 | 89 | 150232 | 18258 | 63320443 |
Impaired healing | 18.25 | 9.69 | 155 | 150166 | 102387 | 63236314 |
Depressed level of consciousness | 18.24 | 9.69 | 226 | 150095 | 61852 | 63276849 |
Device difficult to use | 18.20 | 9.69 | 4 | 150317 | 12792 | 63325909 |
Mental status changes postoperative | 17.98 | 9.69 | 9 | 150312 | 191 | 63338510 |
Presyncope | 17.93 | 9.69 | 120 | 150201 | 27665 | 63311036 |
Cytomegalovirus infection | 17.90 | 9.69 | 14 | 150307 | 20938 | 63317763 |
Rheumatoid factor increased | 17.90 | 9.69 | 22 | 150299 | 1827 | 63336874 |
Stoma site haemorrhage | 17.88 | 9.69 | 17 | 150304 | 1054 | 63337647 |
Renal tubular acidosis | 17.80 | 9.69 | 21 | 150300 | 1671 | 63337030 |
Illness anxiety disorder | 17.69 | 9.69 | 8 | 150313 | 134 | 63338567 |
Grip strength decreased | 17.68 | 9.69 | 16 | 150305 | 22271 | 63316430 |
Purple glove syndrome | 17.44 | 9.69 | 9 | 150312 | 204 | 63338497 |
Coma scale normal | 17.43 | 9.69 | 4 | 150317 | 4 | 63338697 |
Carotid artery stenosis | 17.29 | 9.69 | 38 | 150283 | 5132 | 63333569 |
Fatigue | 17.22 | 9.69 | 1841 | 148480 | 886187 | 62452514 |
Muscular weakness | 17.21 | 9.69 | 395 | 149926 | 121958 | 63216743 |
Neutropenia | 17.19 | 9.69 | 301 | 150020 | 174704 | 63163997 |
Coronary artery stenosis | 17.17 | 9.69 | 36 | 150285 | 4708 | 63333993 |
Productive cough | 17.16 | 9.69 | 84 | 150237 | 63124 | 63275577 |
Blood pressure diastolic decreased | 17.09 | 9.69 | 102 | 150219 | 22604 | 63316097 |
Bradyarrhythmia | 17.07 | 9.69 | 23 | 150298 | 2092 | 63336609 |
Urine odour abnormal | 17.05 | 9.69 | 43 | 150278 | 6346 | 63332355 |
Pseudopolyposis | 17.05 | 9.69 | 5 | 150316 | 21 | 63338680 |
Cerebral haematoma | 17.04 | 9.69 | 31 | 150290 | 3652 | 63335049 |
Urinary incontinence | 17.03 | 9.69 | 132 | 150189 | 31882 | 63306819 |
Total lung capacity increased | 16.96 | 9.69 | 24 | 150297 | 2286 | 63336415 |
Red blood cell sedimentation rate abnormal | 16.95 | 9.69 | 92 | 150229 | 19690 | 63319011 |
Atrioventricular block second degree | 16.93 | 9.69 | 32 | 150289 | 3882 | 63334819 |
Rectal haemorrhage | 16.85 | 9.69 | 184 | 150137 | 48846 | 63289855 |
Dysphagia | 16.78 | 9.69 | 299 | 150022 | 88286 | 63250415 |
Hallucination, visual | 16.71 | 9.69 | 90 | 150231 | 19208 | 63319493 |
Vitamin B12 deficiency | 16.64 | 9.69 | 38 | 150283 | 5265 | 63333436 |
Neurofibrosarcoma | 16.59 | 9.69 | 8 | 150313 | 156 | 63338545 |
Blood triglycerides increased | 16.57 | 9.69 | 66 | 150255 | 12422 | 63326279 |
Liver function test increased | 16.44 | 9.69 | 33 | 150288 | 32778 | 63305923 |
Gingival hypertrophy | 16.37 | 9.69 | 20 | 150301 | 1651 | 63337050 |
Electrocardiogram QRS complex abnormal | 16.33 | 9.69 | 9 | 150312 | 234 | 63338467 |
Cardiac disorder | 16.24 | 9.69 | 188 | 150133 | 50628 | 63288073 |
Pancreatitis acute | 16.15 | 9.69 | 115 | 150206 | 27051 | 63311650 |
Hypomagnesaemia | 16.14 | 9.69 | 120 | 150201 | 28617 | 63310084 |
Limb discomfort | 16.07 | 9.69 | 123 | 150198 | 29593 | 63309108 |
Visceral congestion | 16 | 9.69 | 10 | 150311 | 330 | 63338371 |
Therapy interrupted | 15.96 | 9.69 | 33 | 150288 | 32422 | 63306279 |
Therapy partial responder | 15.85 | 9.69 | 3 | 150318 | 10655 | 63328046 |
Renal artery stenosis | 15.78 | 9.69 | 21 | 150300 | 1888 | 63336813 |
Gallbladder disorder | 15.73 | 9.69 | 87 | 150234 | 18755 | 63319946 |
Purpura senile | 15.70 | 9.69 | 12 | 150309 | 551 | 63338150 |
Unresponsive to stimuli | 15.60 | 9.69 | 135 | 150186 | 33681 | 63305020 |
Multiple sclerosis | 15.57 | 9.69 | 105 | 150216 | 24267 | 63314434 |
Vertigo | 15.49 | 9.69 | 213 | 150108 | 59674 | 63279027 |
Lung diffusion test decreased | 15.47 | 9.69 | 13 | 150308 | 685 | 63338016 |
Injection site discomfort | 15.45 | 9.69 | 34 | 150287 | 4596 | 63334105 |
Resorption bone increased | 15.41 | 9.69 | 17 | 150304 | 1257 | 63337444 |
Blood creatine phosphokinase increased | 15.38 | 9.69 | 124 | 150197 | 30306 | 63308395 |
Depressed mood | 15.31 | 9.69 | 154 | 150167 | 40037 | 63298664 |
Bundle branch block left | 15.31 | 9.69 | 44 | 150277 | 7015 | 63331686 |
Furuncle | 15.29 | 9.69 | 42 | 150279 | 6524 | 63332177 |
Breast cancer stage III | 15.28 | 9.69 | 3 | 150318 | 10383 | 63328318 |
Adrenal insufficiency | 15.14 | 9.69 | 83 | 150238 | 17832 | 63320869 |
High density lipoprotein decreased | 15.14 | 9.69 | 22 | 150299 | 2148 | 63336553 |
Sleep disorder due to a general medical condition | 15.09 | 9.69 | 5 | 150316 | 12183 | 63326518 |
Sinus arrhythmia | 15.03 | 9.69 | 18 | 150303 | 1455 | 63337246 |
Bone disorder | 14.92 | 9.69 | 94 | 150227 | 21232 | 63317469 |
Cardiac flutter | 14.72 | 9.69 | 31 | 150290 | 4065 | 63334636 |
Epistaxis | 14.69 | 9.69 | 248 | 150073 | 72477 | 63266224 |
Cystocele | 14.56 | 9.69 | 16 | 150305 | 1178 | 63337523 |
Peak expiratory flow rate decreased | 14.53 | 9.69 | 12 | 150309 | 617 | 63338084 |
Polyp | 14.48 | 9.69 | 41 | 150280 | 6480 | 63332221 |
Blood chloride decreased | 14.48 | 9.69 | 37 | 150284 | 5505 | 63333196 |
Weight increased | 14.46 | 9.69 | 489 | 149832 | 260303 | 63078398 |
Haemorrhagic vasculitis | 14.44 | 9.69 | 6 | 150315 | 81 | 63338620 |
Cardiac stress test abnormal | 14.40 | 9.69 | 12 | 150309 | 625 | 63338076 |
Joint noise | 14.37 | 9.69 | 32 | 150289 | 4360 | 63334341 |
Peripheral coldness | 14.34 | 9.69 | 62 | 150259 | 12103 | 63326598 |
Pain in extremity | 14.31 | 9.69 | 939 | 149382 | 330547 | 63008154 |
Circulatory collapse | 14.30 | 9.69 | 95 | 150226 | 21843 | 63316858 |
Intracranial haematoma | 14.29 | 9.69 | 10 | 150311 | 400 | 63338301 |
Joint range of motion decreased | 14.29 | 9.69 | 35 | 150286 | 32393 | 63306308 |
Arteriosclerosis coronary artery | 14.27 | 9.69 | 48 | 150273 | 8325 | 63330376 |
Blood catecholamines decreased | 14.21 | 9.69 | 4 | 150317 | 14 | 63338687 |
Forced vital capacity decreased | 14.11 | 9.69 | 15 | 150306 | 1064 | 63337637 |
Mitral valve incompetence | 14.10 | 9.69 | 87 | 150234 | 19507 | 63319194 |
Chronic kidney disease | 14.08 | 9.69 | 167 | 150154 | 45231 | 63293470 |
Diverticulum | 14.05 | 9.69 | 61 | 150260 | 11930 | 63326771 |
C-reactive protein increased | 14.02 | 9.69 | 308 | 150013 | 94399 | 63244302 |
Cyanosis | 14.00 | 9.69 | 78 | 150243 | 16857 | 63321844 |
Ageusia | 13.97 | 9.69 | 67 | 150254 | 13661 | 63325040 |
Lymphocyte count decreased | 13.86 | 9.69 | 32 | 150289 | 30225 | 63308476 |
Drug hypersensitivity | 13.82 | 9.69 | 598 | 149723 | 310089 | 63028612 |
Intestinal ischaemia | 13.80 | 9.69 | 44 | 150277 | 7424 | 63331277 |
Malaise | 13.70 | 9.69 | 1153 | 149168 | 414801 | 62923900 |
Increased appetite | 13.68 | 9.69 | 52 | 150269 | 9578 | 63329123 |
Breast calcifications | 13.67 | 9.69 | 16 | 150305 | 1262 | 63337439 |
Glomerulonephritis acute | 13.57 | 9.69 | 6 | 150315 | 95 | 63338606 |
Adverse drug reaction | 13.52 | 9.69 | 122 | 150199 | 79592 | 63259109 |
Hepatic function abnormal | 13.48 | 9.69 | 44 | 150277 | 37098 | 63301603 |
Microgenia | 13.42 | 9.69 | 4 | 150317 | 18 | 63338683 |
Tenosynovitis | 13.41 | 9.69 | 8 | 150313 | 13787 | 63324914 |
Confusional state | 13.35 | 9.69 | 686 | 149635 | 235694 | 63103007 |
Urinary tract infection | 13.33 | 9.69 | 760 | 149561 | 263924 | 63074777 |
Fasting | 13.24 | 9.69 | 4 | 150317 | 19 | 63338682 |
Haematotoxicity | 13.20 | 9.69 | 3 | 150318 | 9373 | 63329328 |
Peripheral swelling | 13.08 | 9.69 | 506 | 149815 | 265436 | 63073265 |
Optic disc haemorrhage | 13.03 | 9.69 | 6 | 150315 | 105 | 63338596 |
Product residue present | 13.03 | 9.69 | 29 | 150292 | 3950 | 63334751 |
Swelling face | 13.02 | 9.69 | 217 | 150104 | 63258 | 63275443 |
Anhedonia | 12.99 | 9.69 | 56 | 150265 | 10918 | 63327783 |
Colon cancer | 12.94 | 9.69 | 52 | 150269 | 9826 | 63328875 |
Thyrotoxic crisis | 12.94 | 9.69 | 13 | 150308 | 863 | 63337838 |
Laryngeal pain | 12.77 | 9.69 | 31 | 150290 | 4467 | 63334234 |
Cardiac arrest | 12.77 | 9.69 | 298 | 150023 | 92247 | 63246454 |
Heavy menstrual bleeding | 12.68 | 9.69 | 14 | 150307 | 17759 | 63320942 |
Caesarean section | 12.61 | 9.69 | 13 | 150308 | 17019 | 63321682 |
Respiratory depression | 12.59 | 9.69 | 65 | 150256 | 13650 | 63325051 |
Dysphonia | 12.58 | 9.69 | 170 | 150151 | 47444 | 63291257 |
Intestinal haemorrhage | 12.55 | 9.69 | 28 | 150293 | 3819 | 63334882 |
Ischaemic stroke | 12.47 | 9.69 | 79 | 150242 | 17878 | 63320823 |
Lip dry | 12.40 | 9.69 | 11 | 150310 | 15459 | 63323242 |
Mucosal inflammation | 12.37 | 9.69 | 63 | 150258 | 46865 | 63291836 |
Supraventricular extrasystoles | 12.37 | 9.69 | 31 | 150290 | 4558 | 63334143 |
Yawning | 12.36 | 9.69 | 14 | 150307 | 1066 | 63337635 |
Cytopenia | 12.34 | 9.69 | 6 | 150315 | 11595 | 63327106 |
Product substitution error | 12.33 | 9.69 | 4 | 150317 | 25 | 63338676 |
Cerebellar haematoma | 12.31 | 9.69 | 9 | 150312 | 386 | 63338315 |
Muscle spasms | 12.31 | 9.69 | 469 | 149852 | 155681 | 63183020 |
Blood osmolarity decreased | 12.31 | 9.69 | 13 | 150308 | 915 | 63337786 |
Colorectal adenocarcinoma | 12.31 | 9.69 | 6 | 150315 | 120 | 63338581 |
Vitamin D deficiency | 12.17 | 9.69 | 65 | 150256 | 13827 | 63324874 |
Laryngospasm | 12.17 | 9.69 | 24 | 150297 | 3004 | 63335697 |
Hyperglycaemia | 12.11 | 9.69 | 152 | 150169 | 41715 | 63296986 |
Hepatotoxicity | 12.02 | 9.69 | 46 | 150275 | 36995 | 63301706 |
Dysdiadochokinesis | 12.00 | 9.69 | 6 | 150315 | 127 | 63338574 |
Dystrophic calcification | 11.96 | 9.69 | 6 | 150315 | 128 | 63338573 |
Contrast media reaction | 11.90 | 9.69 | 14 | 150307 | 1111 | 63337590 |
Cerebral ischaemia | 11.85 | 9.69 | 39 | 150282 | 6689 | 63332012 |
Diastolic dysfunction | 11.84 | 9.69 | 38 | 150283 | 6433 | 63332268 |
Musculoskeletal discomfort | 11.83 | 9.69 | 78 | 150243 | 17889 | 63320812 |
Renal injury | 11.82 | 9.69 | 49 | 150272 | 9390 | 63329311 |
Autoimmune nephritis | 11.78 | 9.69 | 9 | 150312 | 413 | 63338288 |
Dysuria | 11.77 | 9.69 | 127 | 150194 | 33611 | 63305090 |
Rash pustular | 11.76 | 9.69 | 41 | 150280 | 7241 | 63331460 |
Disorientation | 11.74 | 9.69 | 144 | 150177 | 39308 | 63299393 |
Muscle spasticity | 11.73 | 9.69 | 21 | 150300 | 21773 | 63316928 |
Gastrointestinal haemorrhage | 11.70 | 9.69 | 263 | 150058 | 80913 | 63257788 |
Cardiac neoplasm unspecified | 11.68 | 9.69 | 5 | 150316 | 73 | 63338628 |
Upper respiratory tract infection | 11.66 | 9.69 | 131 | 150190 | 81916 | 63256785 |
Postoperative wound infection | 11.62 | 9.69 | 54 | 150267 | 10871 | 63327830 |
Renal artery fibromuscular dysplasia | 11.55 | 9.69 | 3 | 150318 | 7 | 63338694 |
Gilbert's syndrome | 11.55 | 9.69 | 3 | 150318 | 7 | 63338694 |
Sputum discoloured | 11.52 | 9.69 | 13 | 150308 | 16334 | 63322367 |
Night sweats | 11.52 | 9.69 | 68 | 150253 | 48746 | 63289955 |
Cutaneous lupus erythematosus | 11.51 | 9.69 | 22 | 150299 | 2690 | 63336011 |
Entropion | 11.50 | 9.69 | 5 | 150316 | 76 | 63338625 |
Blood potassium decreased | 11.49 | 9.69 | 151 | 150170 | 41875 | 63296826 |
Adenocarcinoma of colon | 11.49 | 9.69 | 21 | 150300 | 2483 | 63336218 |
IIIrd nerve paresis | 11.43 | 9.69 | 6 | 150315 | 141 | 63338560 |
Pneumocystis jirovecii pneumonia | 11.34 | 9.69 | 14 | 150307 | 16900 | 63321801 |
Peau d'orange | 11.32 | 9.69 | 6 | 150315 | 144 | 63338557 |
Tarsal tunnel syndrome | 11.32 | 9.69 | 10 | 150311 | 564 | 63338137 |
Intramedullary rod insertion | 11.29 | 9.69 | 19 | 150302 | 2104 | 63336597 |
Interstitial lung disease | 11.28 | 9.69 | 93 | 150228 | 61815 | 63276886 |
Peripheral venous disease | 11.25 | 9.69 | 12 | 150309 | 15465 | 63323236 |
Gestational diabetes | 11.21 | 9.69 | 3 | 150318 | 8393 | 63330308 |
Premature labour | 11.14 | 9.69 | 8 | 150313 | 12496 | 63326205 |
Pulmonary arterial hypertension | 11.06 | 9.69 | 23 | 150298 | 22554 | 63316147 |
Haemorrhoids | 11.06 | 9.69 | 90 | 150231 | 22060 | 63316641 |
Gastric ulcer haemorrhage | 11.04 | 9.69 | 31 | 150290 | 4877 | 63333824 |
Extrasystoles | 11.03 | 9.69 | 32 | 150289 | 5128 | 63333573 |
Electrocardiogram ST-T change | 10.91 | 9.69 | 13 | 150308 | 1045 | 63337656 |
Saliva discolouration | 10.88 | 9.69 | 4 | 150317 | 38 | 63338663 |
Ventricular dysfunction | 10.87 | 9.69 | 22 | 150299 | 2806 | 63335895 |
Transplant rejection | 10.84 | 9.69 | 6 | 150315 | 10774 | 63327927 |
Swollen tongue | 10.79 | 9.69 | 128 | 150193 | 34672 | 63304029 |
Blood alkaline phosphatase increased | 10.77 | 9.69 | 152 | 150169 | 42815 | 63295886 |
Mediastinal haemorrhage | 10.77 | 9.69 | 3 | 150318 | 10 | 63338691 |
Vertigo positional | 10.75 | 9.69 | 22 | 150299 | 2827 | 63335874 |
Torsade de pointes | 10.71 | 9.69 | 61 | 150260 | 13290 | 63325411 |
Cardiac valve disease | 10.71 | 9.69 | 28 | 150293 | 4224 | 63334477 |
Weight decreased | 10.70 | 9.69 | 777 | 149544 | 276021 | 63062680 |
Miosis | 10.69 | 9.69 | 40 | 150281 | 7313 | 63331388 |
Retinal vein thrombosis | 10.60 | 9.69 | 9 | 150312 | 481 | 63338220 |
Quadriparesis | 10.58 | 9.69 | 18 | 150303 | 2011 | 63336690 |
Nervousness | 10.53 | 9.69 | 116 | 150205 | 30863 | 63307838 |
Rhythm idioventricular | 10.49 | 9.69 | 7 | 150314 | 259 | 63338442 |
Ventricular extrasystoles | 10.46 | 9.69 | 55 | 150266 | 11632 | 63327069 |
Low density lipoprotein increased | 10.45 | 9.69 | 36 | 150285 | 6321 | 63332380 |
Intentional product misuse | 10.43 | 9.69 | 93 | 150228 | 60824 | 63277877 |
Proctalgia | 10.39 | 9.69 | 35 | 150286 | 6075 | 63332626 |
Nasal dryness | 10.37 | 9.69 | 29 | 150292 | 4552 | 63334149 |
Nausea | 10.28 | 9.69 | 2229 | 148092 | 852242 | 62486459 |
Female sexual arousal disorder | 10.28 | 9.69 | 4 | 150317 | 45 | 63338656 |
Blood uric acid increased | 10.26 | 9.69 | 32 | 150289 | 5335 | 63333366 |
Ear infection | 10.25 | 9.69 | 51 | 150270 | 38162 | 63300539 |
Gout | 10.24 | 9.69 | 60 | 150261 | 13211 | 63325490 |
Tubular breast carcinoma | 10.20 | 9.69 | 4 | 150317 | 46 | 63338655 |
Vascular access site pain | 10.12 | 9.69 | 5 | 150316 | 103 | 63338598 |
Gastric ulcer | 10.09 | 9.69 | 94 | 150227 | 23943 | 63314758 |
Breath sounds abnormal | 10.07 | 9.69 | 52 | 150269 | 10921 | 63327780 |
Concussion | 10.06 | 9.69 | 46 | 150275 | 9198 | 63329503 |
Supraventricular tachycardia | 10.04 | 9.69 | 63 | 150258 | 14208 | 63324493 |
Respiratory disorder | 10.00 | 9.69 | 53 | 150268 | 39029 | 63299672 |
Nodal arrhythmia | 9.93 | 9.69 | 13 | 150308 | 1150 | 63337551 |
Chorioretinal disorder | 9.87 | 9.69 | 5 | 150316 | 109 | 63338592 |
Azotaemia | 9.82 | 9.69 | 28 | 150293 | 4443 | 63334258 |
Ear, nose and throat examination abnormal | 9.81 | 9.69 | 3 | 150318 | 15 | 63338686 |
Halo vision | 9.79 | 9.69 | 8 | 150313 | 405 | 63338296 |
Stridor | 9.76 | 9.69 | 24 | 150297 | 3486 | 63335215 |
Somnolence | 9.76 | 9.69 | 517 | 149804 | 178168 | 63160533 |
Vulvovaginal discomfort | 9.74 | 9.69 | 19 | 150302 | 2359 | 63336342 |
Continuous haemodiafiltration | 9.74 | 9.69 | 12 | 150309 | 999 | 63337702 |
International normalised ratio decreased | 9.71 | 9.69 | 28 | 150293 | 4473 | 63334228 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Bradycardia | 520.03 | 10.27 | 824 | 95632 | 74594 | 34785881 |
Off label use | 322.87 | 10.27 | 412 | 96044 | 419112 | 34441363 |
Myocardial infarction | 268.94 | 10.27 | 839 | 95617 | 120246 | 34740229 |
Completed suicide | 203.94 | 10.27 | 665 | 95791 | 97503 | 34762972 |
Coronary artery disease | 194.62 | 10.27 | 419 | 96037 | 47886 | 34812589 |
Sinus bradycardia | 181.88 | 10.27 | 201 | 96255 | 12762 | 34847713 |
Syncope | 123.60 | 10.27 | 540 | 95916 | 90911 | 34769564 |
Hypotension | 122.03 | 10.27 | 1035 | 95421 | 220614 | 34639861 |
Product use in unapproved indication | 119.16 | 10.27 | 90 | 96366 | 117409 | 34743066 |
Cardiac failure congestive | 110.46 | 10.27 | 489 | 95967 | 82781 | 34777694 |
Drug abuse | 99.06 | 10.27 | 77 | 96379 | 99019 | 34761456 |
Cerebrovascular accident | 86.53 | 10.27 | 462 | 95994 | 84349 | 34776126 |
Drug ineffective | 85.87 | 10.27 | 827 | 95629 | 455924 | 34404551 |
Febrile neutropenia | 84.85 | 10.27 | 155 | 96301 | 136694 | 34723781 |
Death | 82.93 | 10.27 | 702 | 95754 | 397347 | 34463128 |
Angina unstable | 82.42 | 10.27 | 129 | 96327 | 11524 | 34848951 |
Rhabdomyolysis | 74.12 | 10.27 | 378 | 96078 | 67785 | 34792690 |
COVID-19 | 74.07 | 10.27 | 63 | 96393 | 77487 | 34782988 |
Chest pain | 73.35 | 10.27 | 599 | 95857 | 126163 | 34734312 |
Acute myocardial infarction | 72.35 | 10.27 | 317 | 96139 | 53402 | 34807073 |
Intentional product use issue | 71.32 | 10.27 | 38 | 96418 | 59778 | 34800697 |
Angina pectoris | 70.97 | 10.27 | 219 | 96237 | 31144 | 34829331 |
Pyrexia | 70.31 | 10.27 | 585 | 95871 | 332428 | 34528047 |
Neutropenia | 57.51 | 10.27 | 230 | 96226 | 156548 | 34703927 |
Condition aggravated | 57.43 | 10.27 | 304 | 96152 | 191892 | 34668583 |
Hyperkalaemia | 56.41 | 10.27 | 356 | 96100 | 69033 | 34791442 |
IgM nephropathy | 55.67 | 10.27 | 19 | 96437 | 119 | 34860356 |
Orthostatic hypotension | 53.17 | 10.27 | 175 | 96281 | 25744 | 34834731 |
Injury | 52.05 | 10.27 | 150 | 96306 | 20537 | 34839938 |
Foetal exposure during pregnancy | 51.98 | 10.27 | 20 | 96436 | 38081 | 34822394 |
Dizziness | 50.84 | 10.27 | 866 | 95590 | 217655 | 34642820 |
Acute kidney injury | 48.36 | 10.27 | 1141 | 95315 | 303847 | 34556628 |
Coronary artery occlusion | 47.48 | 10.27 | 98 | 96358 | 10864 | 34849611 |
Atrioventricular block first degree | 46.68 | 10.27 | 70 | 96386 | 6022 | 34854453 |
Myocardial ischaemia | 45.52 | 10.27 | 128 | 96328 | 17280 | 34843195 |
Coronary artery bypass | 44.42 | 10.27 | 61 | 96395 | 4841 | 34855634 |
Treatment failure | 43.28 | 10.27 | 39 | 96417 | 46658 | 34813817 |
Myalgia | 43.09 | 10.27 | 387 | 96069 | 83723 | 34776752 |
Coronary arterial stent insertion | 42.99 | 10.27 | 55 | 96401 | 4074 | 34856401 |
Confusional state | 40.17 | 10.27 | 589 | 95867 | 143571 | 34716904 |
Therapeutic product effect incomplete | 39.25 | 10.27 | 49 | 96407 | 50492 | 34809983 |
Blood pressure inadequately controlled | 38.87 | 10.27 | 42 | 96414 | 2598 | 34857877 |
Drug resistance | 36.39 | 10.27 | 13 | 96443 | 25914 | 34834561 |
Palpitations | 36.19 | 10.27 | 211 | 96245 | 39775 | 34820700 |
Pneumonia | 36.19 | 10.27 | 745 | 95711 | 361882 | 34498593 |
Atrioventricular block | 36 | 10.27 | 73 | 96383 | 7990 | 34852485 |
Wrong drug | 35.46 | 10.27 | 12 | 96444 | 73 | 34860402 |
Emotional distress | 34.98 | 10.27 | 106 | 96350 | 14920 | 34845555 |
Sinus node dysfunction | 34.25 | 10.27 | 50 | 96406 | 4199 | 34856276 |
Asthenia | 34.18 | 10.27 | 902 | 95554 | 244349 | 34616126 |
Coordination abnormal | 33.88 | 10.27 | 69 | 96387 | 7575 | 34852900 |
Atrioventricular block complete | 31.01 | 10.27 | 75 | 96381 | 9244 | 34851231 |
Sepsis | 30.91 | 10.27 | 302 | 96154 | 166259 | 34694216 |
Plasmapheresis | 30.77 | 10.27 | 16 | 96440 | 314 | 34860161 |
Hospitalisation | 30.50 | 10.27 | 70 | 96386 | 56832 | 34803643 |
General physical health deterioration | 28.95 | 10.27 | 221 | 96235 | 128048 | 34732427 |
Coronary artery stenosis | 28.44 | 10.27 | 74 | 96382 | 9542 | 34850933 |
Malignant spinal cord compression | 28.29 | 10.27 | 12 | 96444 | 145 | 34860330 |
Transient ischaemic attack | 27.83 | 10.27 | 150 | 96306 | 27463 | 34833012 |
Product use issue | 27.65 | 10.27 | 86 | 96370 | 63130 | 34797345 |
Paraplegia | 27.55 | 10.27 | 37 | 96419 | 2874 | 34857601 |
Drug intolerance | 27.53 | 10.27 | 79 | 96377 | 59491 | 34800984 |
Infusion related reaction | 27.06 | 10.27 | 67 | 96389 | 52990 | 34807485 |
Paroxysmal atrioventricular block | 26.95 | 10.27 | 6 | 96450 | 3 | 34860472 |
Shock | 26.89 | 10.27 | 135 | 96321 | 24044 | 34836431 |
Cytokine release syndrome | 26.58 | 10.27 | 15 | 96441 | 22862 | 34837613 |
Contraindicated product administered | 26.56 | 10.27 | 13 | 96443 | 21468 | 34839007 |
Fear | 26.39 | 10.27 | 76 | 96380 | 10400 | 34850075 |
Pacemaker generated rhythm | 25.77 | 10.27 | 9 | 96447 | 61 | 34860414 |
International normalised ratio increased | 25.38 | 10.27 | 220 | 96236 | 47107 | 34813368 |
Anhedonia | 25.19 | 10.27 | 61 | 96395 | 7524 | 34852951 |
Myelosuppression | 24.84 | 10.27 | 11 | 96445 | 19254 | 34841221 |
Nodal arrhythmia | 24.64 | 10.27 | 20 | 96436 | 858 | 34859617 |
Product dose omission issue | 23.93 | 10.27 | 213 | 96243 | 119498 | 34740977 |
Loss of consciousness | 23.88 | 10.27 | 340 | 96116 | 82327 | 34778148 |
Mucosal inflammation | 23.67 | 10.27 | 44 | 96412 | 38578 | 34821897 |
Swelling face | 23.61 | 10.27 | 126 | 96330 | 22979 | 34837496 |
Product complaint | 23.58 | 10.27 | 51 | 96405 | 5839 | 34854636 |
Blood glucose increased | 23.27 | 10.27 | 284 | 96172 | 66434 | 34794041 |
Vasculitic rash | 23.10 | 10.27 | 20 | 96436 | 939 | 34859536 |
Haemophagocytic lymphohistiocytosis | 23.04 | 10.27 | 4 | 96452 | 12969 | 34847506 |
Blood creatine phosphokinase increased | 22.75 | 10.27 | 206 | 96250 | 44651 | 34815824 |
Antiacetylcholine receptor antibody positive | 22.56 | 10.27 | 8 | 96448 | 57 | 34860418 |
Circulatory collapse | 22.37 | 10.27 | 116 | 96340 | 20922 | 34839553 |
Drop attacks | 22.37 | 10.27 | 16 | 96440 | 567 | 34859908 |
Encapsulating peritoneal sclerosis | 22.22 | 10.27 | 16 | 96440 | 573 | 34859902 |
Diverticulum | 22.11 | 10.27 | 56 | 96400 | 7103 | 34853372 |
Optic ischaemic neuropathy | 22.10 | 10.27 | 28 | 96428 | 2054 | 34858421 |
Drug ineffective for unapproved indication | 21.74 | 10.27 | 20 | 96436 | 23695 | 34836780 |
Hypovolaemia | 21.36 | 10.27 | 65 | 96391 | 9169 | 34851306 |
Metabolic acidosis | 21.35 | 10.27 | 199 | 96257 | 43481 | 34816994 |
Leukopenia | 21.29 | 10.27 | 95 | 96361 | 62761 | 34797714 |
Lethargy | 20.93 | 10.27 | 189 | 96267 | 40933 | 34819542 |
Renal injury | 20.68 | 10.27 | 73 | 96383 | 11122 | 34849353 |
Pulmonary oedema | 20.52 | 10.27 | 211 | 96245 | 47318 | 34813157 |
Rheumatoid arthritis | 20.52 | 10.27 | 47 | 96409 | 38191 | 34822284 |
Neutrophil count decreased | 19.97 | 10.27 | 73 | 96383 | 51031 | 34809444 |
Pulmonary fibrosis | 19.96 | 10.27 | 102 | 96354 | 18294 | 34842181 |
Diabetic neuropathy | 19.94 | 10.27 | 39 | 96417 | 4158 | 34856317 |
Allergy to animal | 19.90 | 10.27 | 13 | 96443 | 396 | 34860079 |
COVID-19 pneumonia | 19.89 | 10.27 | 11 | 96445 | 16956 | 34843519 |
Presyncope | 19.52 | 10.27 | 104 | 96352 | 18955 | 34841520 |
C-reactive protein increased | 19.40 | 10.27 | 80 | 96376 | 54018 | 34806457 |
Arteriosclerosis coronary artery | 19.39 | 10.27 | 77 | 96379 | 12408 | 34848067 |
Hypertension | 19.29 | 10.27 | 503 | 95953 | 135940 | 34724535 |
Oedema peripheral | 19.12 | 10.27 | 449 | 96007 | 119363 | 34741112 |
Heart rate decreased | 18.85 | 10.27 | 151 | 96305 | 31594 | 34828881 |
Drug interaction | 18.77 | 10.27 | 782 | 95674 | 225164 | 34635311 |
Erectile dysfunction | 18.73 | 10.27 | 109 | 96347 | 20528 | 34839947 |
Renal failure | 18.66 | 10.27 | 482 | 95974 | 130075 | 34730400 |
Ventricular hypertrophy | 18.57 | 10.27 | 40 | 96416 | 4567 | 34855908 |
Cardiac arrest | 18.42 | 10.27 | 370 | 96086 | 95789 | 34764686 |
Inappropriate schedule of product administration | 18.30 | 10.27 | 99 | 96357 | 62197 | 34798278 |
Tongue oedema | 18.24 | 10.27 | 31 | 96425 | 2966 | 34857509 |
Guillain-Barre syndrome | 18.17 | 10.27 | 47 | 96409 | 6040 | 34854435 |
Hyperlactacidaemia | 18.09 | 10.27 | 31 | 96425 | 2985 | 34857490 |
Hyponatraemia | 17.83 | 10.27 | 324 | 96132 | 82367 | 34778108 |
Cytomegalovirus infection | 17.64 | 10.27 | 28 | 96428 | 26107 | 34834368 |
Iron binding capacity total increased | 17.52 | 10.27 | 6 | 96450 | 38 | 34860437 |
Acute coronary syndrome | 17.51 | 10.27 | 79 | 96377 | 13466 | 34847009 |
Atrial fibrillation | 17.24 | 10.27 | 451 | 96005 | 121942 | 34738533 |
Blood cholesterol increased | 17.05 | 10.27 | 106 | 96350 | 20437 | 34840038 |
Hypertensive crisis | 16.98 | 10.27 | 58 | 96398 | 8693 | 34851782 |
Dyskinesia oesophageal | 16.01 | 10.27 | 6 | 96450 | 51 | 34860424 |
Abdominal compartment syndrome | 15.52 | 10.27 | 16 | 96440 | 937 | 34859538 |
Blood creatinine increased | 15.48 | 10.27 | 357 | 96099 | 94619 | 34765856 |
Vascular graft | 15.42 | 10.27 | 20 | 96436 | 1502 | 34858973 |
Cerebral haematoma | 15.20 | 10.27 | 37 | 96419 | 4578 | 34855897 |
Therapy partial responder | 14.97 | 10.27 | 4 | 96452 | 9612 | 34850863 |
Immune reconstitution inflammatory syndrome | 14.91 | 10.27 | 3 | 96453 | 8756 | 34851719 |
Vertigo | 14.90 | 10.27 | 121 | 96335 | 25415 | 34835060 |
Toxic epidermal necrolysis | 14.79 | 10.27 | 23 | 96433 | 21623 | 34838852 |
Nail pigmentation | 14.75 | 10.27 | 7 | 96449 | 112 | 34860363 |
Hypophagia | 14.66 | 10.27 | 115 | 96341 | 23907 | 34836568 |
Fall | 14.60 | 10.27 | 692 | 95764 | 202193 | 34658282 |
Neurotoxicity | 14.47 | 10.27 | 17 | 96439 | 17993 | 34842482 |
Atrioventricular block second degree | 14.26 | 10.27 | 32 | 96424 | 3756 | 34856719 |
Nasopharyngitis | 14.19 | 10.27 | 124 | 96332 | 69844 | 34790631 |
Anxiety | 14.18 | 10.27 | 367 | 96089 | 99061 | 34761414 |
Hyperglycaemia | 14.17 | 10.27 | 169 | 96287 | 39311 | 34821164 |
Hyperlipidaemia | 14.01 | 10.27 | 78 | 96378 | 14451 | 34846024 |
Influenza | 14.00 | 10.27 | 80 | 96376 | 49586 | 34810889 |
Disease progression | 13.91 | 10.27 | 212 | 96244 | 107865 | 34752610 |
Retinal infarction | 13.91 | 10.27 | 7 | 96449 | 128 | 34860347 |
Electrocardiogram QRS complex prolonged | 13.80 | 10.27 | 37 | 96419 | 4857 | 34855618 |
Blood pressure increased | 13.69 | 10.27 | 329 | 96127 | 87773 | 34772702 |
Drug dependence | 13.62 | 10.27 | 29 | 96427 | 24188 | 34836287 |
Ventricular dysfunction | 13.61 | 10.27 | 32 | 96424 | 3873 | 34856602 |
Pulse absent | 13.57 | 10.27 | 41 | 96415 | 5762 | 34854713 |
Angioedema | 13.42 | 10.27 | 160 | 96296 | 37214 | 34823261 |
Therapeutic product effect decreased | 13.33 | 10.27 | 50 | 96406 | 34693 | 34825782 |
Anuria | 13.00 | 10.27 | 60 | 96396 | 10325 | 34850150 |
Ischaemic cardiomyopathy | 12.97 | 10.27 | 43 | 96413 | 6346 | 34854129 |
Asthma | 12.96 | 10.27 | 67 | 96389 | 42589 | 34817886 |
Abnormal dreams | 12.80 | 10.27 | 48 | 96408 | 7530 | 34852945 |
Synovitis | 12.73 | 10.27 | 12 | 96444 | 14054 | 34846421 |
Poisoning | 12.71 | 10.27 | 67 | 96389 | 12159 | 34848316 |
Pseudodementia | 12.62 | 10.27 | 3 | 96453 | 3 | 34860472 |
Food aversion | 12.52 | 10.27 | 10 | 96446 | 419 | 34860056 |
Dehydration | 12.46 | 10.27 | 457 | 95999 | 129512 | 34730963 |
Pulmonary valve incompetence | 12.46 | 10.27 | 14 | 96442 | 905 | 34859570 |
Hypoglycaemia | 12.45 | 10.27 | 216 | 96240 | 54424 | 34806051 |
Blood pressure immeasurable | 12.41 | 10.27 | 14 | 96442 | 909 | 34859566 |
Thrombotic microangiopathy | 12.31 | 10.27 | 7 | 96449 | 10623 | 34849852 |
Hepatic function abnormal | 12.21 | 10.27 | 72 | 96384 | 44291 | 34816184 |
Cardiac failure | 12.08 | 10.27 | 178 | 96278 | 91070 | 34769405 |
Intentional product misuse | 12.05 | 10.27 | 75 | 96381 | 45536 | 34814939 |
Myocarditis | 12.00 | 10.27 | 12 | 96444 | 13670 | 34846805 |
Hypomagnesaemia | 11.93 | 10.27 | 102 | 96354 | 21749 | 34838726 |
Malignant neoplasm progression | 11.92 | 10.27 | 171 | 96285 | 87875 | 34772600 |
Gastric ulcer | 11.91 | 10.27 | 79 | 96377 | 15571 | 34844904 |
Pseudomonas infection | 11.88 | 10.27 | 10 | 96446 | 12372 | 34848103 |
Itching scar | 11.87 | 10.27 | 4 | 96452 | 24 | 34860451 |
Nitritoid reaction | 11.87 | 10.27 | 4 | 96452 | 24 | 34860451 |
Infection | 11.81 | 10.27 | 178 | 96278 | 90737 | 34769738 |
Nodal rhythm | 11.66 | 10.27 | 17 | 96439 | 1426 | 34859049 |
Bronchopulmonary aspergillosis | 11.60 | 10.27 | 14 | 96442 | 14645 | 34845830 |
Dupuytren's contracture | 11.41 | 10.27 | 3 | 96453 | 6 | 34860469 |
Cardio-respiratory arrest | 11.36 | 10.27 | 215 | 96241 | 55058 | 34805417 |
Non-small cell lung cancer stage IIIB | 11.34 | 10.27 | 4 | 96452 | 28 | 34860447 |
Aldolase increased | 11.33 | 10.27 | 5 | 96451 | 67 | 34860408 |
Duodenitis | 11.18 | 10.27 | 34 | 96422 | 4794 | 34855681 |
Haemodialysis | 11.16 | 10.27 | 58 | 96398 | 10468 | 34850007 |
Tachypnoea | 11.16 | 10.27 | 21 | 96435 | 18331 | 34842144 |
Mitral valve incompetence | 11.11 | 10.27 | 75 | 96381 | 14868 | 34845607 |
Spermatozoa progressive motility decreased | 11.01 | 10.27 | 6 | 96450 | 130 | 34860345 |
Spermatozoa progressive motility abnormal | 10.99 | 10.27 | 4 | 96452 | 31 | 34860444 |
Renal arteriosclerosis | 10.96 | 10.27 | 7 | 96449 | 205 | 34860270 |
Bladder irritation | 10.94 | 10.27 | 5 | 96451 | 73 | 34860402 |
Sinoatrial block | 10.93 | 10.27 | 10 | 96446 | 505 | 34859970 |
Abscess | 10.79 | 10.27 | 10 | 96446 | 11807 | 34848668 |
Pneumocystis jirovecii pneumonia | 10.76 | 10.27 | 24 | 96432 | 19686 | 34840789 |
Crystal urine | 10.70 | 10.27 | 5 | 96451 | 77 | 34860398 |
Primary hyperaldosteronism | 10.70 | 10.27 | 5 | 96451 | 77 | 34860398 |
Epididymitis | 10.67 | 10.27 | 22 | 96434 | 2437 | 34858038 |
Premature baby | 10.64 | 10.27 | 24 | 96432 | 19609 | 34840866 |
Illness | 10.62 | 10.27 | 13 | 96443 | 13516 | 34846959 |
Labile hypertension | 10.59 | 10.27 | 5 | 96451 | 79 | 34860396 |
Blood pressure fluctuation | 10.58 | 10.27 | 35 | 96421 | 25214 | 34835261 |
Ultrasound Doppler abnormal | 10.55 | 10.27 | 3 | 96453 | 9 | 34860466 |
Colitis | 10.53 | 10.27 | 61 | 96395 | 37689 | 34822786 |
Seizure | 10.52 | 10.27 | 215 | 96241 | 104642 | 34755833 |
Drug reaction with eosinophilia and systemic symptoms | 10.52 | 10.27 | 51 | 96405 | 32961 | 34827514 |
Thyrotoxic periodic paralysis | 10.50 | 10.27 | 6 | 96450 | 143 | 34860332 |
Anticoagulation drug level above therapeutic | 10.46 | 10.27 | 20 | 96436 | 2096 | 34858379 |
Aspergillus infection | 10.46 | 10.27 | 11 | 96445 | 12243 | 34848232 |
Carotid artery stenosis | 10.39 | 10.27 | 34 | 96422 | 4985 | 34855490 |
Gravitational oedema | 10.33 | 10.27 | 11 | 96445 | 669 | 34859806 |
Clostridium difficile infection | 10.32 | 10.27 | 23 | 96433 | 18875 | 34841600 |
Peripheral vascular disorder | 10.32 | 10.27 | 34 | 96422 | 5002 | 34855473 |
QRS axis abnormal | 10.31 | 10.27 | 15 | 96441 | 1256 | 34859219 |
Product substitution issue | 10.28 | 10.27 | 55 | 96401 | 10040 | 34850435 |
Ocular myasthenia | 10.28 | 10.27 | 7 | 96449 | 229 | 34860246 |
Cardiac valve disease | 10.27 | 10.27 | 25 | 96431 | 3093 | 34857382 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Bradycardia | 1090.16 | 9.64 | 1517 | 199353 | 134040 | 79409478 |
Off label use | 472.97 | 9.64 | 988 | 199882 | 906227 | 78637291 |
Myocardial infarction | 429.03 | 9.64 | 1224 | 199646 | 182905 | 79360613 |
Coronary artery disease | 328.69 | 9.64 | 591 | 200279 | 64883 | 79478635 |
Cardiac failure congestive | 306.02 | 9.64 | 920 | 199950 | 141482 | 79402036 |
Sinus bradycardia | 302.19 | 9.64 | 345 | 200525 | 24902 | 79518616 |
Hypotension | 299.23 | 9.64 | 2015 | 198855 | 438302 | 79105216 |
Completed suicide | 267.77 | 9.64 | 1277 | 199593 | 244490 | 79299028 |
Cerebrovascular accident | 242.58 | 9.64 | 901 | 199969 | 154391 | 79389127 |
Pemphigus | 222.59 | 9.64 | 6 | 200864 | 99576 | 79443942 |
Syncope | 222.59 | 9.64 | 969 | 199901 | 178480 | 79365038 |
Hand deformity | 212.93 | 9.64 | 12 | 200858 | 103907 | 79439611 |
Maternal exposure during pregnancy | 188.32 | 9.64 | 55 | 200815 | 136483 | 79407035 |
Systemic lupus erythematosus | 184.06 | 9.64 | 40 | 200830 | 121109 | 79422409 |
Product use in unapproved indication | 183.63 | 9.64 | 216 | 200654 | 250143 | 79293375 |
Pericarditis | 178.91 | 9.64 | 25 | 200845 | 104211 | 79439307 |
Drug ineffective | 166.04 | 9.64 | 1834 | 199036 | 1079079 | 78464439 |
Acute kidney injury | 154.06 | 9.64 | 1990 | 198880 | 517414 | 79026104 |
Intentional product use issue | 149.03 | 9.64 | 100 | 200770 | 152012 | 79391506 |
Glossodynia | 134.69 | 9.64 | 46 | 200824 | 103291 | 79440227 |
Pyrexia | 131.34 | 9.64 | 1087 | 199783 | 677622 | 78865896 |
Angina unstable | 128.16 | 9.64 | 182 | 200688 | 16345 | 79527173 |
Drug interaction | 125.21 | 9.64 | 1596 | 199274 | 413587 | 79129931 |
Duodenal ulcer perforation | 123.26 | 9.64 | 12 | 200858 | 66199 | 79477319 |
Acute myocardial infarction | 121.05 | 9.64 | 448 | 200422 | 76588 | 79466930 |
Febrile neutropenia | 119.26 | 9.64 | 252 | 200618 | 230747 | 79312771 |
Hypertensive crisis | 119.23 | 9.64 | 199 | 200671 | 20571 | 79522947 |
Hyperkalaemia | 115.50 | 9.64 | 582 | 200288 | 113816 | 79429702 |
Wound | 114.30 | 9.64 | 76 | 200794 | 116103 | 79427415 |
Therapeutic product effect incomplete | 111.73 | 9.64 | 115 | 200755 | 141530 | 79401988 |
Hyponatraemia | 110.44 | 9.64 | 797 | 200073 | 177051 | 79366467 |
Rhabdomyolysis | 110.03 | 9.64 | 533 | 200337 | 102598 | 79440920 |
Nasopharyngitis | 108.97 | 9.64 | 305 | 200565 | 253576 | 79289942 |
Discomfort | 107.24 | 9.64 | 95 | 200775 | 125522 | 79417996 |
Drug abuse | 105.25 | 9.64 | 154 | 200716 | 162537 | 79380981 |
Drug intolerance | 103.50 | 9.64 | 331 | 200539 | 263788 | 79279730 |
Folliculitis | 103.19 | 9.64 | 10 | 200860 | 55370 | 79488148 |
Shock | 102.68 | 9.64 | 291 | 200579 | 43257 | 79500261 |
Electric shock | 102.60 | 9.64 | 56 | 200814 | 1338 | 79542180 |
Angina pectoris | 102.43 | 9.64 | 325 | 200545 | 51407 | 79492111 |
Atrial fibrillation | 101.89 | 9.64 | 849 | 200021 | 197037 | 79346481 |
General physical health deterioration | 101.64 | 9.64 | 354 | 200516 | 274884 | 79268634 |
Infection | 99.62 | 9.64 | 296 | 200574 | 241416 | 79302102 |
Treatment failure | 97.51 | 9.64 | 175 | 200695 | 170311 | 79373207 |
Atrioventricular block first degree | 94.57 | 9.64 | 136 | 200734 | 12355 | 79531163 |
Dizziness | 93.08 | 9.64 | 1851 | 199019 | 524590 | 79018928 |
Muscle injury | 92.54 | 9.64 | 8 | 200862 | 48553 | 79494965 |
Infusion related reaction | 90.57 | 9.64 | 288 | 200582 | 229949 | 79313569 |
Coordination abnormal | 87.76 | 9.64 | 157 | 200713 | 17155 | 79526363 |
Coronary arterial stent insertion | 86.94 | 9.64 | 91 | 200779 | 5953 | 79537565 |
COVID-19 | 83.89 | 9.64 | 169 | 200701 | 157505 | 79386013 |
Condition aggravated | 81.44 | 9.64 | 838 | 200032 | 500286 | 79043232 |
Sleep disorder due to general medical condition, insomnia type | 80.79 | 9.64 | 8 | 200862 | 43548 | 79499970 |
Renal failure | 80.05 | 9.64 | 816 | 200054 | 200152 | 79343366 |
Chest pain | 79.86 | 9.64 | 1073 | 199797 | 281231 | 79262287 |
Hypersensitivity | 77.49 | 9.64 | 368 | 200502 | 261871 | 79281647 |
Exposure during pregnancy | 76.52 | 9.64 | 85 | 200785 | 101047 | 79442471 |
Synovitis | 74.82 | 9.64 | 168 | 200702 | 150566 | 79392952 |
International normalised ratio increased | 73.19 | 9.64 | 413 | 200457 | 84308 | 79459210 |
Heart rate decreased | 71.83 | 9.64 | 359 | 200511 | 69957 | 79473561 |
Blood pressure inadequately controlled | 71.53 | 9.64 | 83 | 200787 | 6094 | 79537424 |
Therapeutic product effect decreased | 70.91 | 9.64 | 196 | 200674 | 163667 | 79379851 |
Dehydration | 70.45 | 9.64 | 944 | 199926 | 247243 | 79296275 |
Neutropenia | 69.95 | 9.64 | 431 | 200439 | 287279 | 79256239 |
Contraindicated product administered | 69.24 | 9.64 | 187 | 200683 | 157351 | 79386167 |
Stomatitis | 68.49 | 9.64 | 169 | 200701 | 146588 | 79396930 |
Sinusitis | 68.46 | 9.64 | 257 | 200613 | 195244 | 79348274 |
Alopecia | 68.14 | 9.64 | 325 | 200545 | 231030 | 79312488 |
Transient ischaemic attack | 67.88 | 9.64 | 288 | 200582 | 52407 | 79491111 |
Coronary artery occlusion | 62.92 | 9.64 | 127 | 200743 | 15188 | 79528330 |
Fall | 61.34 | 9.64 | 1635 | 199235 | 485994 | 79057524 |
Blister | 60.24 | 9.64 | 132 | 200738 | 119344 | 79424174 |
Asthenia | 59.67 | 9.64 | 1699 | 199171 | 509990 | 79033528 |
Asthma | 59.63 | 9.64 | 160 | 200710 | 134935 | 79408583 |
Intervertebral discitis | 59.50 | 9.64 | 67 | 200803 | 4761 | 79538757 |
Hepatic enzyme increased | 58.27 | 9.64 | 249 | 200621 | 182361 | 79361157 |
Drug resistance | 58.18 | 9.64 | 17 | 200853 | 42196 | 79501322 |
Myalgia | 57.67 | 9.64 | 718 | 200152 | 184923 | 79358595 |
Confusional state | 57.38 | 9.64 | 1122 | 199748 | 316875 | 79226643 |
IgM nephropathy | 57.37 | 9.64 | 19 | 200851 | 119 | 79543399 |
Haematocrit decreased | 57.05 | 9.64 | 305 | 200565 | 61007 | 79482511 |
Myocardial ischaemia | 56.75 | 9.64 | 167 | 200703 | 25352 | 79518166 |
Swelling | 56.18 | 9.64 | 318 | 200552 | 216393 | 79327125 |
Atrioventricular block complete | 55.87 | 9.64 | 127 | 200743 | 16483 | 79527035 |
Neovascularisation | 55.00 | 9.64 | 36 | 200834 | 1209 | 79542309 |
Loss of consciousness | 53.21 | 9.64 | 652 | 200218 | 167291 | 79376227 |
Death | 52.50 | 9.64 | 1059 | 199811 | 565455 | 78978063 |
Atrioventricular block | 52.48 | 9.64 | 112 | 200758 | 13929 | 79529589 |
Myelosuppression | 52.39 | 9.64 | 18 | 200852 | 40278 | 79503240 |
Ventricular hypertrophy | 51.73 | 9.64 | 75 | 200795 | 6863 | 79536655 |
Blood creatinine increased | 51.32 | 9.64 | 607 | 200263 | 154450 | 79389068 |
Post-traumatic stress disorder | 50.61 | 9.64 | 62 | 200808 | 4819 | 79538699 |
Product complaint | 49.34 | 9.64 | 106 | 200764 | 13243 | 79530275 |
Blood glucose increased | 49.22 | 9.64 | 474 | 200396 | 114501 | 79429017 |
Lactic acidosis | 48.75 | 9.64 | 324 | 200546 | 70035 | 79473483 |
Loss of employment | 48.48 | 9.64 | 45 | 200825 | 2542 | 79540976 |
Palpitations | 47.97 | 9.64 | 509 | 200361 | 126101 | 79417417 |
Metabolic acidosis | 47.85 | 9.64 | 364 | 200506 | 82165 | 79461353 |
Poisoning | 47.51 | 9.64 | 156 | 200714 | 25116 | 79518402 |
Coronary artery bypass | 47.36 | 9.64 | 67 | 200803 | 5995 | 79537523 |
Orthostatic hypotension | 46.67 | 9.64 | 271 | 200599 | 55893 | 79487625 |
Product use issue | 45.59 | 9.64 | 325 | 200545 | 209497 | 79334021 |
Demyelination | 44.89 | 9.64 | 76 | 200794 | 7947 | 79535571 |
Device expulsion | 44.84 | 9.64 | 6 | 200864 | 25855 | 79517663 |
Sinus node dysfunction | 44.48 | 9.64 | 74 | 200796 | 7627 | 79535891 |
Pneumonia | 43.97 | 9.64 | 1297 | 199573 | 658949 | 78884569 |
Abdominal discomfort | 43.69 | 9.64 | 412 | 200458 | 250315 | 79293203 |
Cytomegalovirus infection | 43.15 | 9.64 | 27 | 200843 | 42617 | 79500901 |
Exposure via ingestion | 43.13 | 9.64 | 59 | 200811 | 5115 | 79538403 |
Hypertension | 42.76 | 9.64 | 1114 | 199756 | 329878 | 79213640 |
Arthropathy | 42.66 | 9.64 | 266 | 200604 | 176845 | 79366673 |
Rheumatoid factor positive | 42.36 | 9.64 | 53 | 200817 | 59786 | 79483732 |
Irritable bowel syndrome | 42.13 | 9.64 | 57 | 200813 | 62184 | 79481334 |
Ill-defined disorder | 41.95 | 9.64 | 63 | 200807 | 65812 | 79477706 |
Coronary artery stenosis | 41.49 | 9.64 | 95 | 200775 | 12389 | 79531129 |
Fibromyalgia | 41.49 | 9.64 | 61 | 200809 | 64279 | 79479239 |
Emotional distress | 41.48 | 9.64 | 205 | 200665 | 39764 | 79503754 |
Mucosal inflammation | 41.05 | 9.64 | 80 | 200790 | 75500 | 79468018 |
Sinus arrest | 40.82 | 9.64 | 48 | 200822 | 3574 | 79539944 |
Hyperlipidaemia | 40.34 | 9.64 | 151 | 200719 | 25942 | 79517576 |
Psoriatic arthropathy | 40.29 | 9.64 | 85 | 200785 | 77914 | 79465604 |
Overdose | 40.26 | 9.64 | 670 | 200200 | 183536 | 79359982 |
Anuria | 39.94 | 9.64 | 130 | 200740 | 20833 | 79522685 |
Hospitalisation | 39.80 | 9.64 | 114 | 200756 | 94122 | 79449396 |
Rectal polyp | 39.06 | 9.64 | 33 | 200837 | 1644 | 79541874 |
Product dose omission issue | 38.87 | 9.64 | 417 | 200453 | 247120 | 79296398 |
Blood pressure increased | 38.50 | 9.64 | 747 | 200123 | 210613 | 79332905 |
Blood urea increased | 38.34 | 9.64 | 232 | 200638 | 48558 | 79494960 |
Lethargy | 38.24 | 9.64 | 342 | 200528 | 80950 | 79462568 |
Neutrophil count decreased | 37.99 | 9.64 | 116 | 200754 | 93843 | 79449675 |
Hypokalaemia | 37.63 | 9.64 | 540 | 200330 | 143500 | 79400018 |
Circulatory collapse | 37.54 | 9.64 | 191 | 200679 | 37477 | 79506041 |
Haemodialysis | 36.74 | 9.64 | 115 | 200755 | 18053 | 79525465 |
Pulmonary oedema | 35.89 | 9.64 | 360 | 200510 | 87894 | 79455624 |
Temperature intolerance | 35.80 | 9.64 | 77 | 200793 | 9628 | 79533890 |
Hypoglycaemia | 35.52 | 9.64 | 402 | 200468 | 101192 | 79442326 |
Frustration tolerance decreased | 35.45 | 9.64 | 66 | 200804 | 7436 | 79536082 |
Oedema peripheral | 34.29 | 9.64 | 855 | 200015 | 251433 | 79292085 |
Blood potassium increased | 33.90 | 9.64 | 155 | 200715 | 29120 | 79514398 |
Blood pressure systolic increased | 33.16 | 9.64 | 285 | 200585 | 66701 | 79476817 |
Blood creatine phosphokinase increased | 33.14 | 9.64 | 282 | 200588 | 65808 | 79477710 |
Fear | 32.97 | 9.64 | 126 | 200744 | 21860 | 79521658 |
Melaena | 32.77 | 9.64 | 264 | 200606 | 60626 | 79482892 |
Diverticulum | 32.66 | 9.64 | 97 | 200773 | 14799 | 79528719 |
Blood pressure immeasurable | 32.65 | 9.64 | 33 | 200837 | 2071 | 79541447 |
Joint swelling | 32.21 | 9.64 | 522 | 200348 | 288124 | 79255394 |
Cytokine release syndrome | 32.21 | 9.64 | 26 | 200844 | 35972 | 79507546 |
Fear of eating | 32.07 | 9.64 | 18 | 200852 | 455 | 79543063 |
Aspergillus infection | 31.93 | 9.64 | 5 | 200865 | 19156 | 79524362 |
Depression | 31.66 | 9.64 | 742 | 200128 | 216048 | 79327470 |
Cerebral haematoma | 31.61 | 9.64 | 65 | 200805 | 7877 | 79535641 |
Cardiac arrest | 31.25 | 9.64 | 608 | 200262 | 171488 | 79372030 |
Lower respiratory tract infection | 31.15 | 9.64 | 194 | 200676 | 129026 | 79414492 |
Wheezing | 30.86 | 9.64 | 170 | 200700 | 116494 | 79427024 |
Renal injury | 30.49 | 9.64 | 103 | 200767 | 16824 | 79526694 |
Presyncope | 30.24 | 9.64 | 192 | 200678 | 40862 | 79502656 |
Vulvovaginal burning sensation | 30.05 | 9.64 | 28 | 200842 | 1589 | 79541929 |
Anhedonia | 29.85 | 9.64 | 94 | 200776 | 14804 | 79528714 |
Haemophagocytic lymphohistiocytosis | 29.72 | 9.64 | 9 | 200861 | 21828 | 79521690 |
Post cholecystectomy syndrome | 29.55 | 9.64 | 16 | 200854 | 376 | 79543142 |
Hypomagnesaemia | 29.52 | 9.64 | 211 | 200659 | 46700 | 79496818 |
Product substitution issue | 29.49 | 9.64 | 115 | 200755 | 20141 | 79523377 |
Malignant neoplasm progression | 29.35 | 9.64 | 211 | 200659 | 135779 | 79407739 |
Pain | 29.24 | 9.64 | 1462 | 199408 | 702340 | 78841178 |
Malignant spinal cord compression | 29.20 | 9.64 | 12 | 200858 | 147 | 79543371 |
Cardiac disorder | 28.58 | 9.64 | 272 | 200598 | 65485 | 79478033 |
Cardiogenic shock | 28.42 | 9.64 | 192 | 200678 | 41722 | 79501796 |
Device dislocation | 28.33 | 9.64 | 15 | 200855 | 25955 | 79517563 |
Vasculitic rash | 28.10 | 9.64 | 31 | 200839 | 2153 | 79541365 |
Therapy partial responder | 27.97 | 9.64 | 5 | 200865 | 17392 | 79526126 |
Arteriosclerosis | 27.78 | 9.64 | 105 | 200765 | 18122 | 79525396 |
Intentional product misuse | 27.23 | 9.64 | 135 | 200735 | 95030 | 79448488 |
Knee arthroplasty | 26.92 | 9.64 | 42 | 200828 | 43206 | 79500312 |
COVID-19 pneumonia | 26.87 | 9.64 | 20 | 200850 | 28829 | 79514689 |
Hyperglycaemia | 26.74 | 9.64 | 283 | 200587 | 70052 | 79473466 |
Gastrointestinal disorder | 26.67 | 9.64 | 189 | 200681 | 122016 | 79421502 |
Arteriosclerosis coronary artery | 26.63 | 9.64 | 102 | 200768 | 17714 | 79525804 |
Multiple fractures | 26.59 | 9.64 | 61 | 200809 | 7965 | 79535553 |
Nodal rhythm | 26.51 | 9.64 | 36 | 200834 | 3099 | 79540419 |
Premature delivery | 26.43 | 9.64 | 13 | 200857 | 23454 | 79520064 |
Pacemaker generated rhythm | 26.20 | 9.64 | 9 | 200861 | 64 | 79543454 |
Angioedema | 26.18 | 9.64 | 300 | 200570 | 75735 | 79467783 |
Blood glucose decreased | 26.12 | 9.64 | 133 | 200737 | 26101 | 79517417 |
Dilatation atrial | 26.12 | 9.64 | 39 | 200831 | 3665 | 79539853 |
Diabetic neuropathy | 26.08 | 9.64 | 52 | 200818 | 6164 | 79537354 |
Atrioventricular block second degree | 25.82 | 9.64 | 57 | 200813 | 7255 | 79536263 |
Incorrect route of product administration | 25.71 | 9.64 | 30 | 200840 | 34899 | 79508619 |
Disease progression | 25.65 | 9.64 | 319 | 200551 | 184043 | 79359475 |
Hypovolaemia | 25.40 | 9.64 | 100 | 200770 | 17591 | 79525927 |
Hyperhidrosis | 25.11 | 9.64 | 528 | 200342 | 150964 | 79392554 |
Red blood cell count decreased | 25.04 | 9.64 | 238 | 200632 | 57275 | 79486243 |
Hip arthroplasty | 24.96 | 9.64 | 32 | 200838 | 35724 | 79507794 |
Cardiomegaly | 24.45 | 9.64 | 131 | 200739 | 26221 | 79517297 |
Inappropriate schedule of product administration | 24.37 | 9.64 | 217 | 200653 | 133411 | 79410107 |
Sepsis | 24.18 | 9.64 | 506 | 200364 | 268922 | 79274596 |
Rash | 24.07 | 9.64 | 1201 | 199669 | 577157 | 78966361 |
Lacunar infarction | 24.00 | 9.64 | 49 | 200821 | 5908 | 79537610 |
Plasmapheresis | 23.98 | 9.64 | 17 | 200853 | 652 | 79542866 |
Duodenal ulcer | 23.88 | 9.64 | 93 | 200777 | 16276 | 79527242 |
Change of bowel habit | 23.84 | 9.64 | 32 | 200838 | 2725 | 79540793 |
Productive cough | 23.75 | 9.64 | 128 | 200742 | 88203 | 79455315 |
Erectile dysfunction | 23.62 | 9.64 | 86 | 200784 | 14578 | 79528940 |
Vulvovaginal pruritus | 23.44 | 9.64 | 31 | 200839 | 2602 | 79540916 |
Lymphocyte count decreased | 23.21 | 9.64 | 53 | 200817 | 47236 | 79496282 |
Acute coronary syndrome | 23.08 | 9.64 | 110 | 200760 | 21023 | 79522495 |
Intracranial haematoma | 22.94 | 9.64 | 19 | 200851 | 921 | 79542597 |
Weight increased | 22.87 | 9.64 | 528 | 200342 | 276858 | 79266660 |
Helicobacter infection | 22.87 | 9.64 | 94 | 200776 | 69610 | 79473908 |
Laryngospasm | 22.54 | 9.64 | 38 | 200832 | 3959 | 79539559 |
Drug hypersensitivity | 22.45 | 9.64 | 577 | 200293 | 298339 | 79245179 |
Tongue oedema | 22.38 | 9.64 | 53 | 200817 | 7064 | 79536454 |
Confusion postoperative | 22.33 | 9.64 | 11 | 200859 | 211 | 79543307 |
Carotid artery stenosis | 22.10 | 9.64 | 60 | 200810 | 8698 | 79534820 |
Wrong drug | 22.09 | 9.64 | 12 | 200858 | 284 | 79543234 |
Pregnancy | 22.08 | 9.64 | 21 | 200849 | 26830 | 79516688 |
Gingival hypertrophy | 22.03 | 9.64 | 33 | 200837 | 3109 | 79540409 |
Antiacetylcholine receptor antibody positive | 21.95 | 9.64 | 8 | 200862 | 69 | 79543449 |
Therapy interrupted | 21.93 | 9.64 | 28 | 200842 | 31313 | 79512205 |
Peripheral coldness | 21.91 | 9.64 | 89 | 200781 | 15881 | 79527637 |
Cardiac valve disease | 21.69 | 9.64 | 46 | 200824 | 5695 | 79537823 |
Paroxysmal atrioventricular block | 21.40 | 9.64 | 6 | 200864 | 19 | 79543499 |
Vascular graft | 21.39 | 9.64 | 26 | 200844 | 2005 | 79541513 |
Bronchopulmonary aspergillosis | 21.36 | 9.64 | 15 | 200855 | 22279 | 79521239 |
Aspartate aminotransferase | 21.33 | 9.64 | 15 | 200855 | 568 | 79542950 |
Hepatic function abnormal | 21.32 | 9.64 | 103 | 200767 | 73004 | 79470514 |
Mitral valve incompetence | 21.29 | 9.64 | 134 | 200736 | 28431 | 79515087 |
High density lipoprotein decreased | 20.81 | 9.64 | 40 | 200830 | 4615 | 79538903 |
Neurotoxicity | 20.80 | 9.64 | 31 | 200839 | 32487 | 79511031 |
Ulcer | 20.74 | 9.64 | 138 | 200732 | 29834 | 79513684 |
Blood pressure decreased | 20.70 | 9.64 | 359 | 200511 | 99107 | 79444411 |
Leukopenia | 20.47 | 9.64 | 191 | 200679 | 116322 | 79427196 |
Bronchiectasis | 20.24 | 9.64 | 16 | 200854 | 22370 | 79521148 |
Blood immunoglobulin A increased | 20.18 | 9.64 | 18 | 200852 | 965 | 79542553 |
Disability | 20.09 | 9.64 | 91 | 200779 | 17029 | 79526489 |
International normalised ratio decreased | 20.08 | 9.64 | 55 | 200815 | 8015 | 79535503 |
Musculoskeletal stiffness | 20.00 | 9.64 | 315 | 200555 | 174693 | 79368825 |
Liver function test increased | 19.99 | 9.64 | 44 | 200826 | 39729 | 79503789 |
Cytomegalovirus viraemia | 19.94 | 9.64 | 4 | 200866 | 12817 | 79530701 |
Gastric ulcer | 19.90 | 9.64 | 150 | 200720 | 33755 | 79509763 |
Medication error | 19.81 | 9.64 | 262 | 200608 | 68380 | 79475138 |
Swelling face | 19.81 | 9.64 | 270 | 200600 | 70942 | 79472576 |
BRASH syndrome | 19.66 | 9.64 | 18 | 200852 | 999 | 79542519 |
Dyskinesia oesophageal | 19.56 | 9.64 | 7 | 200863 | 57 | 79543461 |
Phaeochromocytoma | 19.52 | 9.64 | 15 | 200855 | 652 | 79542866 |
Hypophagia | 19.39 | 9.64 | 187 | 200683 | 45180 | 79498338 |
Pathogen resistance | 19.36 | 9.64 | 6 | 200864 | 14336 | 79529182 |
Diabetes mellitus | 19.33 | 9.64 | 291 | 200579 | 78099 | 79465419 |
Grip strength decreased | 19.31 | 9.64 | 16 | 200854 | 21853 | 79521665 |
Optic ischaemic neuropathy | 19.22 | 9.64 | 30 | 200840 | 2931 | 79540587 |
Drop attacks | 19.09 | 9.64 | 18 | 200852 | 1037 | 79542481 |
Skull fracture | 19.09 | 9.64 | 23 | 200847 | 1757 | 79541761 |
Femur fracture | 18.89 | 9.64 | 164 | 200706 | 38488 | 79505030 |
Rheumatoid arthritis | 18.85 | 9.64 | 391 | 200479 | 208079 | 79335439 |
Nodal arrhythmia | 18.72 | 9.64 | 24 | 200846 | 1954 | 79541564 |
Ischaemic cardiomyopathy | 18.70 | 9.64 | 52 | 200818 | 7643 | 79535875 |
Muscle spasticity | 18.61 | 9.64 | 16 | 200854 | 21459 | 79522059 |
Anxiety | 18.51 | 9.64 | 784 | 200086 | 247728 | 79295790 |
Haemoglobin decreased | 18.46 | 9.64 | 709 | 200161 | 221410 | 79322108 |
Abnormal dreams | 18.45 | 9.64 | 67 | 200803 | 11345 | 79532173 |
Haematotoxicity | 18.40 | 9.64 | 8 | 200862 | 15511 | 79528007 |
Renal artery stenosis | 18.19 | 9.64 | 32 | 200838 | 3450 | 79540068 |
Phaeochromocytoma crisis | 18.03 | 9.64 | 11 | 200859 | 326 | 79543192 |
Pneumocystis jirovecii pneumonia | 18.01 | 9.64 | 34 | 200836 | 32474 | 79511044 |
Bradyarrhythmia | 17.77 | 9.64 | 35 | 200835 | 4111 | 79539407 |
Impaired quality of life | 17.73 | 9.64 | 7 | 200863 | 14379 | 79529139 |
Sleep disorder due to a general medical condition | 17.51 | 9.64 | 7 | 200863 | 14270 | 79529248 |
Sinus arrhythmia | 17.50 | 9.64 | 24 | 200846 | 2086 | 79541432 |
Deep vein thrombosis postoperative | 17.48 | 9.64 | 3 | 200867 | 10749 | 79532769 |
Guillain-Barre syndrome | 17.44 | 9.64 | 56 | 200814 | 8909 | 79534609 |
Prescribed overdose | 17.37 | 9.64 | 44 | 200826 | 37839 | 79505679 |
Device difficult to use | 17.36 | 9.64 | 6 | 200864 | 13379 | 79530139 |
Blood urine | 17.23 | 9.64 | 16 | 200854 | 904 | 79542614 |
Coma scale normal | 17.18 | 9.64 | 4 | 200866 | 4 | 79543514 |
Rectosigmoid cancer | 17.12 | 9.64 | 10 | 200860 | 273 | 79543245 |
Glomerular filtration rate increased | 17.00 | 9.64 | 18 | 200852 | 1193 | 79542325 |
Post transplant lymphoproliferative disorder | 16.97 | 9.64 | 4 | 200866 | 11460 | 79532058 |
Ventricular dysfunction | 16.97 | 9.64 | 43 | 200827 | 5980 | 79537538 |
Pulse absent | 16.91 | 9.64 | 60 | 200810 | 10043 | 79533475 |
Hyperlactacidaemia | 16.88 | 9.64 | 41 | 200829 | 5554 | 79537964 |
Supraventricular extrasystoles | 16.77 | 9.64 | 47 | 200823 | 6940 | 79536578 |
Laryngeal pain | 16.55 | 9.64 | 43 | 200827 | 6071 | 79537447 |
Arrhythmia | 16.51 | 9.64 | 231 | 200639 | 61041 | 79482477 |
Pruritus | 16.49 | 9.64 | 819 | 200051 | 393829 | 79149689 |
Encapsulating peritoneal sclerosis | 16.33 | 9.64 | 15 | 200855 | 836 | 79542682 |
Paraplegia | 16.29 | 9.64 | 38 | 200832 | 5015 | 79538503 |
Influenza | 16.29 | 9.64 | 229 | 200641 | 129377 | 79414141 |
Hiatus hernia | 15.93 | 9.64 | 107 | 200763 | 23205 | 79520313 |
Total lung capacity increased | 15.92 | 9.64 | 24 | 200846 | 2274 | 79541244 |
Blood triglycerides increased | 15.87 | 9.64 | 99 | 200771 | 20941 | 79522577 |
Ear infection | 15.78 | 9.64 | 40 | 200830 | 34392 | 79509126 |
Vertigo | 15.72 | 9.64 | 253 | 200617 | 68829 | 79474689 |
Cytopenia | 15.56 | 9.64 | 17 | 200853 | 20366 | 79523152 |
Oral candidiasis | 15.54 | 9.64 | 32 | 200838 | 29596 | 79513922 |
Tenosynovitis | 15.53 | 9.64 | 10 | 200860 | 15544 | 79527974 |
Peripheral vascular disorder | 15.48 | 9.64 | 50 | 200820 | 7980 | 79535538 |
Furuncle | 15.44 | 9.64 | 48 | 200822 | 7506 | 79536012 |
Female orgasmic disorder | 15.42 | 9.64 | 5 | 200865 | 29 | 79543489 |
Rhinalgia | 15.39 | 9.64 | 24 | 200846 | 2343 | 79541175 |
Rectal haemorrhage | 15.38 | 9.64 | 274 | 200596 | 76026 | 79467492 |
Potentiating drug interaction | 15.30 | 9.64 | 53 | 200817 | 8766 | 79534752 |
Vitamin B12 increased | 15.23 | 9.64 | 17 | 200853 | 1196 | 79542322 |
Mental status changes postoperative | 15.21 | 9.64 | 8 | 200862 | 177 | 79543341 |
Epistaxis | 15.15 | 9.64 | 378 | 200492 | 111137 | 79432381 |
Haemorrhoids | 14.98 | 9.64 | 125 | 200745 | 29003 | 79514515 |
Urethral repair | 14.96 | 9.64 | 3 | 200867 | 0 | 79543518 |
Cardiac stress test abnormal | 14.89 | 9.64 | 14 | 200856 | 804 | 79542714 |
Purple glove syndrome | 14.86 | 9.64 | 9 | 200861 | 263 | 79543255 |
Urine odour abnormal | 14.86 | 9.64 | 42 | 200828 | 6231 | 79537287 |
Autoimmune disorder | 14.86 | 9.64 | 12 | 200858 | 16600 | 79526918 |
Urinary incontinence | 14.80 | 9.64 | 163 | 200707 | 40746 | 79502772 |
Haemorrhagic stroke | 14.71 | 9.64 | 61 | 200809 | 10985 | 79532533 |
Toxic epidermal necrolysis | 14.70 | 9.64 | 60 | 200810 | 44521 | 79498997 |
Liver injury | 14.69 | 9.64 | 83 | 200787 | 56531 | 79486987 |
Feeling abnormal | 14.64 | 9.64 | 514 | 200356 | 158685 | 79384833 |
Bone erosion | 14.63 | 9.64 | 14 | 200856 | 17833 | 79525685 |
Respiratory tract infection | 14.55 | 9.64 | 68 | 200802 | 48621 | 79494897 |
Unresponsive to stimuli | 14.50 | 9.64 | 209 | 200661 | 55579 | 79487939 |
Granulocyte count increased | 14.43 | 9.64 | 17 | 200853 | 1268 | 79542250 |
Lid lag | 14.42 | 9.64 | 6 | 200864 | 76 | 79543442 |
Ischaemic stroke | 14.37 | 9.64 | 137 | 200733 | 32994 | 79510524 |
Polyp | 14.31 | 9.64 | 49 | 200821 | 8058 | 79535460 |
Infusion site pain | 14.31 | 9.64 | 9 | 200861 | 14167 | 79529351 |
Vertigo positional | 14.14 | 9.64 | 28 | 200842 | 3302 | 79540216 |
Bundle branch block left | 14.11 | 9.64 | 62 | 200808 | 11451 | 79532067 |
Rheumatoid factor increased | 14.04 | 9.64 | 20 | 200850 | 1801 | 79541717 |
Breast calcifications | 13.99 | 9.64 | 14 | 200856 | 868 | 79542650 |
Coronary artery restenosis | 13.97 | 9.64 | 17 | 200853 | 1312 | 79542206 |
Blood catecholamines decreased | 13.97 | 9.64 | 4 | 200866 | 14 | 79543504 |
Continuous haemodiafiltration | 13.89 | 9.64 | 21 | 200849 | 1995 | 79541523 |
Multiple sclerosis | 13.89 | 9.64 | 100 | 200770 | 22182 | 79521336 |
Adjustment disorder with depressed mood | 13.79 | 9.64 | 3 | 200867 | 9083 | 79534435 |
Tricuspid valve incompetence | 13.79 | 9.64 | 91 | 200779 | 19621 | 79523897 |
Neurofibrosarcoma | 13.78 | 9.64 | 8 | 200862 | 216 | 79543302 |
Upper respiratory tract infection | 13.73 | 9.64 | 155 | 200715 | 91013 | 79452505 |
Clostridium difficile infection | 13.73 | 9.64 | 58 | 200812 | 42627 | 79500891 |
Azotaemia | 13.73 | 9.64 | 49 | 200821 | 8227 | 79535291 |
Inappropriate antidiuretic hormone secretion | 13.57 | 9.64 | 113 | 200757 | 26200 | 79517318 |
Hepatitis acute | 13.57 | 9.64 | 76 | 200794 | 15466 | 79528052 |
Purpura senile | 13.53 | 9.64 | 11 | 200859 | 519 | 79542999 |
Laryngotracheal oedema | 13.53 | 9.64 | 5 | 200865 | 45 | 79543473 |
White blood cell count decreased | 13.46 | 9.64 | 366 | 200504 | 187922 | 79355596 |
Iron deficiency | 13.44 | 9.64 | 5 | 200865 | 10649 | 79532869 |
Low density lipoprotein increased | 13.41 | 9.64 | 50 | 200820 | 8572 | 79534946 |
Ankylosing spondylitis | 13.39 | 9.64 | 7 | 200863 | 12198 | 79531320 |
Bundle branch block right | 13.35 | 9.64 | 60 | 200810 | 11191 | 79532327 |
Stoma site haemorrhage | 13.26 | 9.64 | 20 | 200850 | 1896 | 79541622 |
Coma scale abnormal | 13.23 | 9.64 | 50 | 200820 | 8628 | 79534890 |
Pancytopenia | 13.23 | 9.64 | 317 | 200553 | 165428 | 79378090 |
Idiopathic interstitial pneumonia | 13.21 | 9.64 | 8 | 200862 | 234 | 79543284 |
Ventricular extrasystoles | 13.20 | 9.64 | 90 | 200780 | 19614 | 79523904 |
Blood sodium decreased | 13.20 | 9.64 | 135 | 200735 | 33120 | 79510398 |
Coronary artery thrombosis | 13.05 | 9.64 | 26 | 200844 | 3080 | 79540438 |
Peak expiratory flow rate decreased | 13.03 | 9.64 | 12 | 200858 | 671 | 79542847 |
Retinal vein thrombosis | 13.00 | 9.64 | 12 | 200858 | 673 | 79542845 |
Herpes zoster | 12.96 | 9.64 | 161 | 200709 | 92922 | 79450596 |
Haemorrhagic vasculitis | 12.83 | 9.64 | 6 | 200864 | 102 | 79543416 |
Lip dry | 12.75 | 9.64 | 12 | 200858 | 15406 | 79528112 |
Sputum discoloured | 12.71 | 9.64 | 22 | 200848 | 21721 | 79521797 |
Drug dispensed to wrong patient | 12.69 | 9.64 | 12 | 200858 | 694 | 79542824 |
Illness anxiety disorder | 12.65 | 9.64 | 8 | 200862 | 253 | 79543265 |
Neuroleptic malignant syndrome | 12.64 | 9.64 | 32 | 200838 | 27527 | 79515991 |
Hallucination, visual | 12.58 | 9.64 | 132 | 200738 | 32597 | 79510921 |
Acute myeloid leukaemia | 12.57 | 9.64 | 38 | 200832 | 30847 | 79512671 |
Respiratory syncytial virus infection | 12.57 | 9.64 | 4 | 200866 | 9398 | 79534120 |
Haematemesis | 12.49 | 9.64 | 193 | 200677 | 52071 | 79491447 |
Conjunctivitis | 12.47 | 9.64 | 29 | 200841 | 25686 | 79517832 |
Genitourinary symptom | 12.43 | 9.64 | 8 | 200862 | 261 | 79543257 |
Inflammation | 12.37 | 9.64 | 164 | 200706 | 93589 | 79449929 |
Enterocolitis | 12.35 | 9.64 | 11 | 200859 | 14501 | 79529017 |
Cerebral haemorrhage | 12.30 | 9.64 | 209 | 200661 | 57464 | 79486054 |
Spermatozoa progressive motility decreased | 12.26 | 9.64 | 5 | 200865 | 60 | 79543458 |
Duodenitis | 12.23 | 9.64 | 46 | 200824 | 7921 | 79535597 |
Appendicitis | 12.19 | 9.64 | 21 | 200849 | 20773 | 79522745 |
Wrong technique in product usage process | 12.17 | 9.64 | 123 | 200747 | 73752 | 79469766 |
Sinoatrial block | 12.17 | 9.64 | 16 | 200854 | 1335 | 79542183 |
Vitreous detachment | 12.11 | 9.64 | 21 | 200849 | 2238 | 79541280 |
Cystitis haemorrhagic | 12.09 | 9.64 | 4 | 200866 | 9168 | 79534350 |
Coronary artery surgery | 12.09 | 9.64 | 7 | 200863 | 188 | 79543330 |
Swollen tongue | 12.08 | 9.64 | 162 | 200708 | 42408 | 79501110 |
Depressed level of consciousness | 12.07 | 9.64 | 324 | 200546 | 96328 | 79447190 |
Impaired healing | 12.06 | 9.64 | 152 | 200718 | 87503 | 79456015 |
Hypogammaglobulinaemia | 12.03 | 9.64 | 9 | 200861 | 12942 | 79530576 |
Mobility decreased | 11.99 | 9.64 | 226 | 200644 | 121949 | 79421569 |
Adrenal insufficiency | 11.96 | 9.64 | 117 | 200753 | 28370 | 79515148 |
Limb discomfort | 11.94 | 9.64 | 131 | 200739 | 32719 | 79510799 |
Red blood cell sedimentation rate abnormal | 11.89 | 9.64 | 92 | 200778 | 20871 | 79522647 |
Myocarditis | 11.80 | 9.64 | 23 | 200847 | 21710 | 79521808 |
Cystocele | 11.73 | 9.64 | 12 | 200858 | 764 | 79542754 |
Postoperative wound infection | 11.73 | 9.64 | 64 | 200806 | 12897 | 79530621 |
Muscular weakness | 11.72 | 9.64 | 506 | 200364 | 160223 | 79383295 |
Hepatic steatosis | 11.72 | 9.64 | 146 | 200724 | 37592 | 79505926 |
Cold sweat | 11.70 | 9.64 | 84 | 200786 | 18615 | 79524903 |
Facet joint syndrome | 11.65 | 9.64 | 7 | 200863 | 11295 | 79532223 |
Night sweats | 11.64 | 9.64 | 80 | 200790 | 52015 | 79491503 |
Substance abuse | 11.60 | 9.64 | 6 | 200864 | 10520 | 79532998 |
Dialysis | 11.59 | 9.64 | 83 | 200787 | 18379 | 79525139 |
Nitritoid reaction | 11.58 | 9.64 | 4 | 200866 | 29 | 79543489 |
Vision blurred | 11.56 | 9.64 | 349 | 200521 | 105549 | 79437969 |
Drug dependence | 11.56 | 9.64 | 58 | 200812 | 40711 | 79502807 |
Abortion spontaneous | 11.52 | 9.64 | 37 | 200833 | 29470 | 79514048 |
Entropion | 11.51 | 9.64 | 5 | 200865 | 71 | 79543447 |
Pneumonia fungal | 11.48 | 9.64 | 7 | 200863 | 11203 | 79532315 |
Bone disorder | 11.47 | 9.64 | 85 | 200785 | 19028 | 79524490 |
Acne | 11.40 | 9.64 | 33 | 200837 | 27157 | 79516361 |
Dystrophic calcification | 11.40 | 9.64 | 6 | 200864 | 133 | 79543385 |
Tarsal tunnel syndrome | 11.37 | 9.64 | 10 | 200860 | 526 | 79542992 |
Myositis | 11.36 | 9.64 | 85 | 200785 | 19083 | 79524435 |
Peripheral venous disease | 11.35 | 9.64 | 14 | 200856 | 15895 | 79527623 |
Spermatozoa progressive motility abnormal | 11.35 | 9.64 | 4 | 200866 | 31 | 79543487 |
Injection site reaction | 11.34 | 9.64 | 86 | 200784 | 54699 | 79488819 |
BK virus infection | 11.33 | 9.64 | 4 | 200866 | 8800 | 79534718 |
Barrett's oesophagus | 11.31 | 9.64 | 12 | 200858 | 797 | 79542721 |
Hallucination, auditory | 11.28 | 9.64 | 90 | 200780 | 20603 | 79522915 |
Cutaneous lupus erythematosus | 11.28 | 9.64 | 24 | 200846 | 2979 | 79540539 |
Sickle cell anaemia with crisis | 11.27 | 9.64 | 3 | 200867 | 7919 | 79535599 |
Labile hypertension | 11.17 | 9.64 | 10 | 200860 | 539 | 79542979 |
Multiple sclerosis relapse | 11.13 | 9.64 | 70 | 200800 | 46463 | 79497055 |
Heart rate abnormal | 11.04 | 9.64 | 37 | 200833 | 6020 | 79537498 |
Gastritis | 11.00 | 9.64 | 176 | 200694 | 47817 | 79495701 |
Nail pigmentation | 10.90 | 9.64 | 8 | 200862 | 324 | 79543194 |
Wound infection | 10.89 | 9.64 | 28 | 200842 | 23963 | 79519555 |
Itching scar | 10.83 | 9.64 | 4 | 200866 | 36 | 79543482 |
Medical diet | 10.82 | 9.64 | 3 | 200867 | 9 | 79543509 |
Systolic hypertension | 10.80 | 9.64 | 11 | 200859 | 697 | 79542821 |
Spinal shock | 10.73 | 9.64 | 4 | 200866 | 37 | 79543481 |
Injection site discomfort | 10.72 | 9.64 | 33 | 200837 | 5133 | 79538385 |
Extrasystoles | 10.70 | 9.64 | 42 | 200828 | 7377 | 79536141 |
Pancreatitis acute | 10.67 | 9.64 | 180 | 200690 | 49424 | 79494094 |
Dementia Alzheimer's type | 10.66 | 9.64 | 13 | 200857 | 1006 | 79542512 |
Cerebral ischaemia | 10.62 | 9.64 | 56 | 200814 | 11139 | 79532379 |
Cardiac flutter | 10.61 | 9.64 | 32 | 200838 | 4922 | 79538596 |
Adenovirus infection | 10.59 | 9.64 | 4 | 200866 | 8443 | 79535075 |
Balance disorder | 10.58 | 9.64 | 325 | 200545 | 98532 | 79444986 |
Prinzmetal angina | 10.57 | 9.64 | 17 | 200853 | 1703 | 79541815 |
Thyrotoxic periodic paralysis | 10.57 | 9.64 | 6 | 200864 | 155 | 79543363 |
Pericardial haemorrhage | 10.56 | 9.64 | 30 | 200840 | 4465 | 79539053 |
Stridor | 10.55 | 9.64 | 34 | 200836 | 5419 | 79538099 |
Jaundice | 10.54 | 9.64 | 191 | 200679 | 53158 | 79490360 |
Fibromuscular dysplasia | 10.54 | 9.64 | 7 | 200863 | 241 | 79543277 |
Iatrogenic injury | 10.53 | 9.64 | 16 | 200854 | 1527 | 79541991 |
Intentional self-injury | 10.46 | 9.64 | 44 | 200826 | 32375 | 79511143 |
Altered state of consciousness | 10.45 | 9.64 | 66 | 200804 | 43756 | 79499762 |
Thrombotic microangiopathy | 10.39 | 9.64 | 22 | 200848 | 20147 | 79523371 |
Cyanosis | 10.37 | 9.64 | 103 | 200767 | 25079 | 79518439 |
Heavy menstrual bleeding | 10.35 | 9.64 | 12 | 200858 | 13999 | 79529519 |
Gamma-glutamyltransferase abnormal | 10.32 | 9.64 | 10 | 200860 | 596 | 79542922 |
Coronary artery reocclusion | 10.30 | 9.64 | 6 | 200864 | 163 | 79543355 |
Vaginal discharge | 10.29 | 9.64 | 3 | 200867 | 7460 | 79536058 |
Bone hyperpigmentation | 10.28 | 9.64 | 4 | 200866 | 42 | 79543476 |
Pulmonary mass | 10.26 | 9.64 | 38 | 200832 | 28996 | 79514522 |
Foot deformity | 10.25 | 9.64 | 29 | 200841 | 24045 | 79519473 |
Lung disorder | 10.24 | 9.64 | 142 | 200728 | 80415 | 79463103 |
Exaggerated startle response | 10.20 | 9.64 | 4 | 200866 | 43 | 79543475 |
Halo vision | 10.17 | 9.64 | 10 | 200860 | 607 | 79542911 |
Pseudopolyposis | 10.15 | 9.64 | 5 | 200865 | 96 | 79543422 |
Chronic kidney disease | 10.13 | 9.64 | 228 | 200642 | 65926 | 79477592 |
Liver function test abnormal | 10.12 | 9.64 | 223 | 200647 | 64252 | 79479266 |
Abdominal compartment syndrome | 10.11 | 9.64 | 16 | 200854 | 1581 | 79541937 |
Refusal of treatment by relative | 10.11 | 9.64 | 11 | 200859 | 752 | 79542766 |
Immune reconstitution inflammatory syndrome | 10.07 | 9.64 | 12 | 200858 | 13829 | 79529689 |
Faeces discoloured | 10.06 | 9.64 | 115 | 200755 | 29012 | 79514506 |
Cerebrovascular disorder | 9.97 | 9.64 | 26 | 200844 | 3679 | 79539839 |
Venous recanalisation | 9.97 | 9.64 | 3 | 200867 | 13 | 79543505 |
Refusal of treatment by patient | 9.96 | 9.64 | 47 | 200823 | 8944 | 79534574 |
Hypocalcaemia | 9.96 | 9.64 | 179 | 200691 | 49745 | 79493773 |
Cerebellar haematoma | 9.92 | 9.64 | 10 | 200860 | 626 | 79542892 |
Amyotrophic lateral sclerosis | 9.90 | 9.64 | 17 | 200853 | 1798 | 79541720 |
Hydronephrosis | 9.89 | 9.64 | 18 | 200852 | 17436 | 79526082 |
Gastric ulcer haemorrhage | 9.87 | 9.64 | 47 | 200823 | 8980 | 79534538 |
Joint effusion | 9.84 | 9.64 | 19 | 200851 | 17995 | 79525523 |
Ocular myasthenia | 9.81 | 9.64 | 8 | 200862 | 379 | 79543139 |
Vocal cord polypectomy | 9.79 | 9.64 | 3 | 200867 | 14 | 79543504 |
Ear pain | 9.76 | 9.64 | 46 | 200824 | 32823 | 79510695 |
Injection site swelling | 9.75 | 9.64 | 74 | 200796 | 47058 | 79496460 |
Cardiac output decreased | 9.74 | 9.64 | 17 | 200853 | 1821 | 79541697 |
Sensitisation | 9.71 | 9.64 | 24 | 200846 | 3287 | 79540231 |
Colorectal adenocarcinoma | 9.69 | 9.64 | 8 | 200862 | 386 | 79543132 |
Vitamin B12 deficiency | 9.65 | 9.64 | 40 | 200830 | 7201 | 79536317 |
Resorption bone increased | 9.65 | 9.64 | 15 | 200855 | 1460 | 79542058 |
None
Source | Code | Description |
---|---|---|
ATC | C07AB03 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, selective |
ATC | C07BB03 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND THIAZIDES Beta blocking agents, selective, and thiazides |
ATC | C07CB03 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND OTHER DIURETICS Beta blocking agents, selective, and other diuretics |
ATC | C07CB53 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND OTHER DIURETICS Beta blocking agents, selective, and other diuretics |
ATC | C07DB01 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, THIAZIDES AND OTHER DIURETICS Beta blocking agents, selective, thiazides and other diuretics |
ATC | C07FB03 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
FDA MoA | N0000000161 | Adrenergic beta-Antagonists |
FDA EPC | N0000175556 | beta-Adrenergic Blocker |
CHEBI has role | CHEBI:35530 | beta-adrenergic blockers |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
CHEBI has role | CHEBI:66991 | sympatholytic drug |
CHEBI has role | CHEBI:78298 | environmental contaminants |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D058671 | Adrenergic beta-1 Receptor Antagonists |
MeSH PA | D000319 | Adrenergic beta-Antagonists |
MeSH PA | D000889 | Anti-Arrhythmia Agents |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D013565 | Sympatholytics |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Myocardial infarction | indication | 22298006 | DOID:5844 |
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Angina pectoris | indication | 194828000 | |
Chronic heart failure | off-label use | 48447003 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Thyrotoxicosis | off-label use | 90739004 | DOID:7997 |
Mitral valve prolapse | off-label use | 409712001 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Essential tremor | off-label use | 609558009 | DOID:4990 |
Pheochromocytoma Adjunct Therapy | off-label use | ||
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation | off-label use | ||
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia | off-label use | ||
Migraine Prevention | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Psoriasis | contraindication | 9014002 | DOID:8893 |
Hypercholesterolemia | contraindication | 13644009 | |
Complete atrioventricular block | contraindication | 27885002 | |
Depressive disorder | contraindication | 35489007 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Anaphylaxis | contraindication | 39579001 | |
Hypokalemia | contraindication | 43339004 | |
Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
Diabetes mellitus type 1 | contraindication | 46635009 | DOID:9744 |
Sinus bradycardia | contraindication | 49710005 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Oliguria | contraindication | 83128009 | |
Cardiogenic shock | contraindication | 89138009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Raynaud's phenomenon | contraindication | 266261006 | |
Pregnancy, function | contraindication | 289908002 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
First Degree Atrioventricular Heart Block | contraindication | ||
Acutely Decompensated HF Requiring Parenteral Inotropic Therapy | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.92 | acidic |
pKa2 | 9.19 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.30 | WOMBAT-PK | CHEMBL | |||
Beta-2 adrenergic receptor | GPCR | Kd | 5.80 | WOMBAT-PK | |||||
Adenosine receptor A3 | GPCR | IC50 | 8.75 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Kd | 5.93 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Kd | 7.62 | CHEMBL | |||||
Urease | Enzyme | IC50 | 4.19 | CHEMBL |
ID | Source |
---|---|
4018460 | VUID |
N0000146784 | NUI |
D00235 | KEGG_DRUG |
1202 | RXNORM |
C0004147 | UMLSCUI |
CHEBI:55352 | CHEBI |
2TN | PDB_CHEM_ID |
CHEMBL24 | ChEMBL_ID |
DB00335 | DRUGBANK_ID |
D001262 | MESH_DESCRIPTOR_UI |
2249 | PUBCHEM_CID |
548 | IUPHAR_LIGAND_ID |
3801 | INN_ID |
50VV3VW0TI | UNII |
353 | MMSL |
4225 | MMSL |
d00004 | MMSL |
387506000 | SNOMEDCT_US |
87652004 | SNOMEDCT_US |
4018460 | VANDF |
001855 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0752 | TABLET | 50 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0752 | TABLET | 50 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0752 | TABLET | 50 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0753 | TABLET | 100 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0753 | TABLET | 100 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0753 | TABLET | 100 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0787 | TABLET | 25 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0787 | TABLET | 25 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0787 | TABLET | 25 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0218 | TABLET | 25 mg | ORAL | ANDA | 19 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0218 | TABLET | 25 mg | ORAL | ANDA | 19 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0231 | TABLET | 50 mg | ORAL | ANDA | 19 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0231 | TABLET | 50 mg | ORAL | ANDA | 19 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0757 | TABLET | 100 mg | ORAL | ANDA | 19 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0757 | TABLET | 100 mg | ORAL | ANDA | 19 sections |
Atenolol and Chlorthalidone | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0591-5782 | TABLET | 50 mg | ORAL | ANDA | 18 sections |
Atenolol and Chlorthalidone | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0591-5783 | TABLET | 100 mg | ORAL | ANDA | 18 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8026 | TABLET | 25 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8027 | TABLET | 50 mg | ORAL | ANDA | 24 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8372 | TABLET | 25 mg | ORAL | ANDA | 13 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8372 | TABLET | 25 mg | ORAL | ANDA | 13 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8373 | TABLET | 50 mg | ORAL | ANDA | 13 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8373 | TABLET | 50 mg | ORAL | ANDA | 13 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7187 | TABLET | 25 mg | ORAL | ANDA | 19 sections |
ATENOLOL AND CHLORTHALIDONE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10135-733 | TABLET | 50 mg | ORAL | ANDA | 21 sections |
ATENOLOL AND CHLORTHALIDONE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10135-734 | TABLET | 100 mg | ORAL | ANDA | 21 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-031 | TABLET | 50 mg | ORAL | ANDA | 18 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-126 | TABLET | 25 mg | ORAL | ANDA | 18 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-127 | TABLET | 50 mg | ORAL | ANDA | 17 sections |
Atenolol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-134 | TABLET | 25 mg | ORAL | ANDA | 17 sections |