atenolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 255 29122-68-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • atenolol
  • (RS)-Atenolol
  • (+/-)-Atenolol
  • betablok
A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
  • Molecular weight: 266.34
  • Formula: C14H22N2O3
  • CLOGP: -0.11
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 84.58
  • ALOGS: -2.79
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 24.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 94 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 12.50 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 56 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.95 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.94 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 19, 1981 FDA ALVOGEN IPCO SARL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 1856.11 32.07 428 3333 9553 2344771
Completed suicide 1423.87 32.07 403 3358 20631 2333693
Hypotension 1161.04 32.07 381 3380 32055 2322269
Toxicity to various agents 780.97 32.07 285 3476 32469 2321855
Overdose 704.54 32.07 233 3528 19674 2334650
Syncope 594.23 32.07 197 3564 16678 2337646
Sinus bradycardia 465.92 32.07 105 3656 2011 2352313
Drug interaction 440.89 32.07 183 3578 28980 2325344
Loss of consciousness 328.24 32.07 131 3630 18636 2335688
Shock 319.10 32.07 88 3673 3916 2350408
Suicide attempt 307.32 32.07 109 3652 11173 2343151
Fall 302.54 32.07 164 3597 46935 2307389
Dizziness 295.12 32.07 174 3587 58491 2295833
Cardiac arrest 274.03 32.07 108 3653 14822 2339502
Intentional overdose 240.02 32.07 91 3670 11230 2343094
Poisoning 238.57 32.07 65 3696 2755 2351569
Malaise 238.33 32.07 149 3612 55436 2298888
Acute kidney injury 234.83 32.07 117 3644 28005 2326319
Heart rate decreased 230.36 32.07 67 3694 3609 2350715
Orthostatic hypotension 223.36 32.07 62 3699 2817 2351507
Asthenia 219.34 32.07 133 3628 46793 2307531
Drug hypersensitivity 214.91 32.07 131 3630 46512 2307812
Somnolence 208.70 32.07 102 3659 23383 2330941
Hypertension 205.46 32.07 106 3655 27255 2327069
Vomiting 183.74 32.07 140 3621 71462 2282862
Dyspnoea 180.51 32.07 144 3617 78589 2275735
Nausea 177.83 32.07 166 3595 112023 2242301
Hyperkalaemia 175.72 32.07 61 3700 5832 2348492
Blood pressure increased 172.74 32.07 81 3680 16905 2337419
Exposure via ingestion 167.20 32.07 38 3723 750 2353574
Medication error 154.43 32.07 56 3705 6075 2348249
Hypokalaemia 150.53 32.07 64 3697 10590 2343734
Blood pressure decreased 145.63 32.07 60 3701 9176 2345148
Palpitations 141.57 32.07 70 3691 16386 2337938
Hypoglycaemia 140.68 32.07 57 3704 8350 2345974
Depressed level of consciousness 139.18 32.07 55 3706 7549 2346775
Atrial fibrillation 137.87 32.07 65 3696 13703 2340621
Coma 136.58 32.07 57 3704 8999 2345325
Hypertensive crisis 136.34 32.07 41 3720 2472 2351852
Tachycardia 135.83 32.07 68 3693 16341 2337983
Respiratory arrest 131.95 32.07 50 3711 6128 2348196
Presyncope 127.49 32.07 43 3718 3760 2350564
Renal failure 126.48 32.07 66 3695 17283 2337041
Atrioventricular block complete 126.07 32.07 34 3727 1380 2352944
Sinus arrest 122.85 32.07 25 3736 284 2354040
Headache 119.56 32.07 115 3646 80064 2274260
Blood creatinine increased 118.72 32.07 54 3707 10479 2343845
Drug ineffective 107.04 32.07 121 3640 101503 2252821
Lactic acidosis 106.13 32.07 41 3720 5289 2349035
Cardio-respiratory arrest 103.40 32.07 47 3714 9099 2345225
Therapy non-responder 102.33 32.07 45 3716 8059 2346265
Product complaint 101.49 32.07 38 3723 4500 2349824
Accidental overdose 98.91 32.07 36 3725 3936 2350388
Confusional state 95.64 32.07 62 3699 24282 2330042
Cardiogenic shock 94.78 32.07 31 3730 2460 2351864
Abdominal pain 93.88 32.07 70 3691 34304 2320020
Oedema peripheral 92.07 32.07 60 3701 23703 2330621
Circulatory collapse 89.97 32.07 33 3728 3687 2350637
Diarrhoea 88.68 32.07 100 3661 83464 2270860
Feeling abnormal 87.60 32.07 58 3703 23523 2330801
Anxiety 87.40 32.07 63 3698 29296 2325028
Vertigo 86.83 32.07 42 3719 9342 2344982
Anaemia 84.32 32.07 66 3695 34726 2319598
Nodal rhythm 84.14 32.07 19 3742 363 2353961
Hyponatraemia 83.84 32.07 46 3715 13279 2341045
Depression 76.11 32.07 57 3704 28075 2326249
Electrocardiogram QT prolonged 75.39 32.07 36 3725 7778 2346546
Atrioventricular block 75.33 32.07 22 3739 1195 2353129
Stoma site haemorrhage 74.98 32.07 14 3747 97 2354227
Condition aggravated 73.89 32.07 59 3702 31920 2322404
Atrioventricular block second degree 73.33 32.07 19 3742 658 2353666
Intestinal ischaemia 73.21 32.07 21 3740 1070 2353254
Drug dispensed to wrong patient 72.71 32.07 12 3749 35 2354289
Pulmonary oedema 71.27 32.07 34 3727 7329 2346995
Respiratory distress 69.66 32.07 30 3731 5099 2349225
Blood urea increased 69.14 32.07 27 3734 3578 2350746
Hypothermia 66.91 32.07 23 3738 2125 2352199
Sopor 66.45 32.07 27 3734 3968 2350356
Haemoglobin decreased 65.81 32.07 44 3717 18107 2336217
Chest pain 65.16 32.07 52 3709 28085 2326239
Lethargy 62.91 32.07 33 3728 8697 2345627
Abdominal pain upper 62.48 32.07 46 3715 22054 2332270
Atrioventricular block first degree 62.15 32.07 18 3743 949 2353375
Arrhythmia 61.90 32.07 29 3732 5999 2348325
Decreased appetite 61.84 32.07 51 3710 28840 2325484
Unresponsive to stimuli 61.27 32.07 27 3734 4849 2349475
Drug reaction with eosinophilia and systemic symptoms 61.19 32.07 28 3733 5490 2348834
Haematocrit decreased 61.09 32.07 26 3735 4292 2350032
Rash 60.86 32.07 70 3691 59488 2294836
Hepatitis 60.52 32.07 29 3732 6308 2348016
Dehydration 59.88 32.07 45 3716 22250 2332074
Exposure during pregnancy 59.22 32.07 47 3714 25172 2329152
Metabolic acidosis 58.96 32.07 28 3733 5970 2348354
Blood pressure inadequately controlled 58.94 32.07 17 3744 883 2353441
Ventricular fibrillation 58.71 32.07 21 3740 2180 2352144
Tremor 58.38 32.07 43 3718 20618 2333706
Paraesthesia 58.02 32.07 44 3717 22044 2332280
Pemphigoid 57.47 32.07 17 3744 965 2353359
Hyperhidrosis 57.37 32.07 38 3723 15384 2338940
Cough 55.80 32.07 51 3710 33066 2321258
Ventricular tachycardia 55.80 32.07 22 3739 2989 2351335
Fatigue 55.60 32.07 80 3681 84793 2269531
Bradyphrenia 55.59 32.07 17 3744 1082 2353242
Insomnia 54.09 32.07 45 3716 25742 2328582
Product substitution issue 53.95 32.07 25 3736 5044 2349280
Drug abuse 53.06 32.07 33 3728 11993 2342331
Pruritus 52.99 32.07 56 3705 43284 2311040
Cardiac failure 52.89 32.07 33 3728 12061 2342263
Coma scale abnormal 51.56 32.07 15 3746 803 2353521
Blood potassium increased 51.30 32.07 19 3742 2177 2352147
Electrocardiogram repolarisation abnormality 51.08 32.07 11 3750 167 2354157
Purpura senile 50.28 32.07 8 3753 17 2354307
Head injury 49.58 32.07 22 3739 4012 2350312
Alopecia 49.50 32.07 40 3721 21961 2332363
Melaena 49.21 32.07 22 3739 4084 2350240
Epistaxis 48.69 32.07 29 3732 9750 2344574
Monoclonal B-cell lymphocytosis 48.19 32.07 7 3754 5 2354319
Cerebrovascular accident 48.18 32.07 38 3723 20148 2334176
Bradyarrhythmia 48.09 32.07 12 3749 356 2353968
Blood lactic acid increased 46.62 32.07 14 3747 837 2353487
Haemodynamic instability 46.16 32.07 15 3746 1164 2353160
Cerebral ischaemia 46.02 32.07 15 3746 1175 2353149
Red blood cell count decreased 45.27 32.07 21 3740 4245 2350079
Pallor 44.68 32.07 20 3741 3722 2350602
Tinnitus 44.52 32.07 22 3739 5113 2349211
Gait disturbance 44.49 32.07 38 3723 22507 2331817
Intentional product misuse 44.30 32.07 27 3734 9462 2344862
Pneumonia 43.80 32.07 54 3707 49242 2305082
Anuria 43.41 32.07 16 3745 1808 2352516
Maternal exposure during pregnancy 42.11 32.07 31 3730 14832 2339492
Poisoning deliberate 41.99 32.07 14 3747 1177 2353147
Interstitial lung disease 41.07 32.07 24 3737 7788 2346536
Sinus arrhythmia 40.66 32.07 10 3751 279 2354045
Heart rate increased 40.40 32.07 27 3734 11078 2343246
Tarsal tunnel syndrome 39.26 32.07 7 3754 36 2354288
Foetal growth restriction 38.60 32.07 13 3748 1127 2353197
Pain in extremity 38.41 32.07 47 3714 42493 2311831
Blood cholesterol increased 38.27 32.07 20 3741 5221 2349103
Vision blurred 38.00 32.07 29 3732 14639 2339685
Renal impairment 37.83 32.07 25 3736 10067 2344257
C-reactive protein increased 37.67 32.07 21 3740 6234 2348090
Acute respiratory distress syndrome 37.42 32.07 17 3744 3275 2351049
Jaundice 37.34 32.07 20 3741 5488 2348836
Angina pectoris 37.31 32.07 18 3743 3969 2350355
Dizziness postural 36.79 32.07 12 3749 942 2353382
Intentional self-injury 36.72 32.07 18 3743 4109 2350215
Hypokinesia 36.69 32.07 14 3747 1740 2352584
Electrocardiogram QRS complex abnormal 36.17 32.07 7 3754 60 2354264
Illness anxiety disorder 36.17 32.07 7 3754 60 2354264
Burning sensation 35.83 32.07 22 3739 7806 2346518
Panic attack 34.44 32.07 17 3744 3939 2350385
Blood pressure immeasurable 34.25 32.07 9 3752 329 2353995
Diabetes mellitus 34.14 32.07 21 3740 7474 2346850
Hyperventilation 33.81 32.07 12 3749 1217 2353107
Hallucination, auditory 33.67 32.07 14 3747 2178 2352146
Weight decreased 33.45 32.07 36 3725 28335 2325989
Agitation 33.45 32.07 24 3737 11027 2343297
Blood glucose increased 33.38 32.07 25 3736 12265 2342059
Suicidal ideation 33.38 32.07 24 3737 11063 2343261
Muscular weakness 33.30 32.07 27 3734 14870 2339454
Concussion 33.21 32.07 11 3750 906 2353418
Death 33.15 32.07 62 3699 81406 2272918
Oligohydramnios 32.71 32.07 11 3750 949 2353375
Alanine aminotransferase increased 32.57 32.07 26 3735 14006 2340318
Bronchospasm 32.43 32.07 15 3746 3009 2351315
Colon cancer 32.31 32.07 13 3748 1860 2352464
Pulseless electrical activity 32.11 32.07 11 3750 1004 2353320

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 2210.59 35.75 539 2975 9995 1733272
Completed suicide 1696.09 35.75 479 3035 15833 1727434
Hypotension 966.62 35.75 363 3151 29291 1713976
Toxicity to various agents 649.16 35.75 272 3242 28869 1714398
Syncope 567.10 35.75 203 3311 13966 1729301
Sinus bradycardia 497.20 35.75 118 3396 1815 1741452
Dizziness 325.42 35.75 179 3335 34182 1709085
Hyperkalaemia 294.35 35.75 110 3404 8437 1734830
Overdose 285.02 35.75 130 3384 16571 1726696
Acute kidney injury 273.86 35.75 161 3353 34783 1708484
Drug interaction 270.70 35.75 148 3366 27810 1715457
Intentional overdose 221.84 35.75 87 3427 7583 1735684
Cardiac arrest 210.21 35.75 104 3410 15826 1727441
Orthostatic hypotension 206.23 35.75 67 3447 3364 1739903
Shock 185.83 35.75 65 3449 4096 1739171
Atrioventricular block first degree 178.46 35.75 45 3469 891 1742376
Presyncope 171.53 35.75 55 3459 2643 1740624
Poisoning 170.80 35.75 54 3460 2478 1740789
Hypertension 165.98 35.75 95 3419 19353 1723914
Circulatory collapse 165.75 35.75 57 3457 3410 1739857
Fall 165.63 35.75 107 3407 27107 1716160
Dyspnoea 161.14 35.75 136 3378 51923 1691344
Blood pressure increased 149.97 35.75 73 3441 10680 1732587
Loss of consciousness 144.04 35.75 79 3435 14796 1728471
Heart rate decreased 137.41 35.75 47 3467 2762 1740505
Cardio-respiratory arrest 132.28 35.75 64 3450 9229 1734038
Atrioventricular block complete 127.29 35.75 38 3476 1433 1741834
Interstitial lung disease 126.72 35.75 63 3451 9633 1733634
Atrioventricular block 125.53 35.75 37 3477 1334 1741933
Malaise 120.54 35.75 91 3423 29474 1713793
Palpitations 118.78 35.75 54 3460 6760 1736507
Suicide attempt 114.65 35.75 54 3460 7327 1735940
Confusional state 113.09 35.75 77 3437 21201 1722066
Asthenia 103.63 35.75 89 3425 34581 1708686
Vertigo 103.06 35.75 43 3471 4370 1738897
Pulmonary fibrosis 99.86 35.75 36 3478 2468 1740799
Lactic acidosis 96.84 35.75 43 3471 5086 1738181
Sinus node dysfunction 96.61 35.75 26 3488 668 1742599
Electrocardiogram QRS complex prolonged 93.77 35.75 26 3488 749 1742518
Renal failure 91.30 35.75 66 3448 19951 1723316
Pulmonary oedema 86.58 35.75 43 3471 6543 1736724
Drug ineffective 86.57 35.75 107 3407 63694 1679573
Atrial fibrillation 83.32 35.75 56 3458 15055 1728212
Hypokalaemia 81.96 35.75 41 3473 6333 1736934
Chest pain 80.33 35.75 61 3453 19853 1723414
Lethargy 77.33 35.75 41 3473 7143 1736124
Nodal arrhythmia 76.57 35.75 17 3497 188 1743079
Metabolic acidosis 73.15 35.75 36 3478 5366 1737901
Drug hypersensitivity 71.46 35.75 51 3463 15084 1728183
Cardiogenic shock 71.33 35.75 28 3486 2426 1740841
Rhabdomyolysis 68.14 35.75 44 3470 11046 1732221
Hyperhidrosis 68.13 35.75 46 3468 12442 1730825
Respiratory arrest 67.60 35.75 35 3479 5804 1737463
Hypoglycaemia 65.86 35.75 39 3475 8399 1734868
Atrioventricular block second degree 61.92 35.75 18 3496 616 1742651
Anticoagulation drug level above therapeutic 61.36 35.75 15 3499 259 1743008
Encapsulating peritoneal sclerosis 61.07 35.75 13 3501 116 1743151
Electrocardiogram QT prolonged 60.65 35.75 32 3482 5513 1737754
Cardiac failure 56.11 35.75 41 3473 12561 1730706
Dehydration 55.99 35.75 47 3467 17611 1725656
Hyponatraemia 53.52 35.75 35 3479 8965 1734302
Depressed level of consciousness 52.82 35.75 31 3483 6561 1736706
Erectile dysfunction 52.17 35.75 27 3487 4470 1738797
Exposure via ingestion 52.07 35.75 16 3498 664 1742603
Vomiting 51.32 35.75 64 3450 38251 1705016
Hyperlactacidaemia 51.19 35.75 14 3500 382 1742885
Arrhythmia 50.07 35.75 29 3485 5987 1737280
Vasoplegia syndrome 50.06 35.75 12 3502 190 1743077
Hepatitis acute 49.81 35.75 18 3496 1239 1742028
Hepatitis 49.70 35.75 27 3487 4928 1738339
Hypoglycaemia neonatal 49.57 35.75 13 3501 301 1742966
Angioedema 48.90 35.75 34 3480 9630 1733637
Drop attacks 48.79 35.75 11 3503 131 1743136
Blood pressure decreased 48.57 35.75 31 3483 7615 1735652
Somnolence 47.86 35.75 42 3472 16697 1726570
Foetal growth restriction 47.78 35.75 15 3499 669 1742598
Coordination abnormal 46.75 35.75 18 3496 1479 1741788
Hypertensive crisis 46.40 35.75 18 3496 1509 1741758
Coma scale abnormal 45.47 35.75 14 3500 585 1742682
Pallor 43.98 35.75 22 3492 3389 1739878
Cold sweat 43.87 35.75 18 3496 1748 1741519
Lichenoid keratosis 41.87 35.75 12 3502 390 1742877
General physical health deterioration 41.72 35.75 35 3479 13083 1730184
Fatigue 41.51 35.75 67 3447 50714 1692553
Blood pressure systolic increased 41.07 35.75 17 3497 1688 1741579
Drug level increased 39.04 35.75 19 3495 2758 1740509
Paroxysmal atrioventricular block 38.30 35.75 6 3508 5 1743262
Paraesthesia 37.67 35.75 30 3484 10421 1732846
Chest discomfort 37.55 35.75 26 3488 7305 1735962
Nail pigmentation 37.47 35.75 7 3507 29 1743238
Renal impairment 37.40 35.75 32 3482 12282 1730985
Wheezing 37.17 35.75 21 3493 4132 1739135
Angina pectoris 36.03 35.75 22 3492 4996 1738271

Pharmacologic Action:

SourceCodeDescription
ATC C07AB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07CB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07CB53 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07DB01 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, THIAZIDES AND OTHER DIURETICS
Beta blocking agents, selective, thiazides and other diuretics
ATC C07FB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D013565 Sympatholytics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Angina pectoris indication 194828000
Chronic heart failure off-label use 48447003
Atrial fibrillation off-label use 49436004 DOID:0060224
Thyrotoxicosis off-label use 90739004 DOID:7997
Mitral valve prolapse off-label use 409712001
Diastolic heart failure off-label use 418304008 DOID:9775
Essential tremor off-label use 609558009 DOID:4990
Pheochromocytoma Adjunct Therapy off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Migraine Prevention off-label use
Anuria contraindication 2472002 DOID:2983
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Complete atrioventricular block contraindication 27885002
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hypochloremic alkalosis contraindication 70134007
Oliguria contraindication 83128009
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Asthma contraindication 195967001 DOID:2841
Acute pancreatitis contraindication 197456007 DOID:2913
Raynaud's phenomenon contraindication 266261006
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
First Degree Atrioventricular Heart Block contraindication
Acutely Decompensated HF Requiring Parenteral Inotropic Therapy contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.92 acidic
pKa2 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.30 WOMBAT-PK CHEMBL
Adenosine receptor A3 GPCR IC50 8.75 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 5.80 WOMBAT-PK
Beta-2 adrenergic receptor GPCR Kd 5.93 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.62 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL

External reference:

IDSource
D001262 MESH_DESCRIPTOR_UI
4018460 VUID
N0000146784 NUI
C0004147 UMLSCUI
D00235 KEGG_DRUG
50VV3VW0TI UNII
3801 INN_ID
87652004 SNOMEDCT_US
353 MMSL
1202 RXNORM
387506000 SNOMEDCT_US
4225 MMSL
d00004 MMSL
4018460 VANDF
001855 NDDF
CHEBI:55352 CHEBI
CHEMBL24 ChEMBL_ID
DB00335 DRUGBANK_ID
2TN PDB_CHEM_ID
548 IUPHAR_LIGAND_ID
2249 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0752 TABLET 50 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0753 TABLET 100 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0787 TABLET 25 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0218 TABLET 25 mg ORAL ANDA 11 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0231 TABLET 50 mg ORAL ANDA 11 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0757 TABLET 100 mg ORAL ANDA 11 sections
Atenolol and Chlorthalidone HUMAN PRESCRIPTION DRUG LABEL 2 0591-5782 TABLET 50 mg ORAL ANDA 12 sections
Atenolol and Chlorthalidone HUMAN PRESCRIPTION DRUG LABEL 2 0591-5783 TABLET 100 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-3532 TABLET 50 mg ORAL ANDA 11 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-3533 TABLET 100 mg ORAL ANDA 11 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-3544 TABLET 25 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8026 TABLET 25 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8027 TABLET 50 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0781-1078 TABLET 25 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0781-1506 TABLET 50 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0781-1507 TABLET 100 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-031 TABLET 50 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-126 TABLET 25 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-127 TABLET 50 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-134 TABLET 25 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-167 TABLET 25 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-171 TABLET 100 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-586 TABLET 50 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 12634-436 TABLET 50 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 12634-604 TABLET 25 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 12634-605 TABLET 100 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 13107-168 TABLET 25 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 13107-169 TABLET 50 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 13107-170 TABLET 100 mg ORAL ANDA 12 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 16571-430 TABLET 25 mg ORAL ANDA 12 sections