atenolol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 255 29122-68-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • atenolol
  • (RS)-Atenolol
  • (+/-)-Atenolol
  • betablok
A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
  • Molecular weight: 266.34
  • Formula: C14H22N2O3
  • CLOGP: -0.11
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 84.58
  • ALOGS: -2.79
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 26.50 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 94 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 12.50 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 56 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.95 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.94 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6.10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK2,PDK4,PRKDC,SIK2,STK33,TEK,TGFBR1 28
kinase-selectivity-class CDK4,EIF2AK3 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.869 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.007 % High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 19, 1981 FDA ALVOGEN IPCO SARL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 797.79 9.46 873 165445 82974 90379155
Pemphigus 562.75 9.46 7 166311 326857 90135272
Systemic lupus erythematosus 493.81 9.46 47 166271 361849 90100280
Hand deformity 461.97 9.46 19 166299 296343 90165786
Glossodynia 420.43 9.46 49 166269 321730 90140399
Pericarditis 418.78 9.46 18 166300 270133 90191996
Maternal exposure during pregnancy 386.39 9.46 93 166225 359970 90102159
Duodenal ulcer perforation 367.16 9.46 8 166310 221280 90240849
Wound 360.95 9.46 61 166257 302919 90159210
Folliculitis 340.56 9.46 7 166311 204346 90257783
Hypotension 317.04 9.46 1309 165009 324088 90138041
Cardiac failure congestive 308.75 9.46 607 165711 98087 90364042
Off label use 284.56 9.46 1054 165264 1101198 89360931
Muscle injury 283.23 9.46 9 166309 176645 90285484
Myocardial infarction 269.82 9.46 599 165719 105373 90356756
Discomfort 237.50 9.46 103 166215 274232 90187897
Cerebrovascular accident 228.92 9.46 618 165700 122915 90339214
Sleep disorder due to general medical condition, insomnia type 208.30 9.46 6 166312 128688 90333441
Sinus bradycardia 205.22 9.46 201 166117 16751 90445378
Syncope 202.51 9.46 619 165699 132044 90330085
Drug interaction 199.78 9.46 1019 165299 275434 90186695
Helicobacter infection 198.19 9.46 84 166234 226766 90235363
Coronary artery disease 196.31 9.46 274 166044 33349 90428780
Irritable bowel syndrome 194.15 9.46 69 166249 207379 90254750
Liver injury 186.88 9.46 42 166276 170525 90291604
Atrial fibrillation 181.60 9.46 599 165719 133012 90329117
General physical health deterioration 179.57 9.46 233 166085 354882 90107247
Blister 176.99 9.46 126 166192 254872 90207257
Intentional product use issue 170.10 9.46 93 166225 216799 90245330
Hyponatraemia 168.55 9.46 584 165734 132954 90329175
Completed suicide 165.71 9.46 614 165704 144444 90317685
Acute kidney injury 164.17 9.46 1078 165240 319309 90142820
Swelling 162.13 9.46 328 165990 418730 90043399
Stomatitis 159.71 9.46 161 166157 274537 90187592
Ill-defined disorder 159.04 9.46 70 166248 184821 90277308
Infection 156.37 9.46 265 166053 361829 90100300
Fall 154.89 9.46 1455 164863 480355 89981774
Fibromyalgia 153.84 9.46 94 166224 206175 90255954
Exposure during pregnancy 152.49 9.46 128 166190 238282 90223847
Infusion related reaction 151.38 9.46 338 165980 416442 90045687
Type 2 diabetes mellitus 151.05 9.46 93 166225 203151 90258978
Wheezing 150.83 9.46 129 166189 237951 90224178
Nasopharyngitis 150.45 9.46 327 165991 406777 90055352
Dehydration 148.33 9.46 728 165590 193719 90268410
Electric shock 146.93 9.46 69 166249 1653 90460476
Renal failure 146.68 9.46 551 165767 130456 90331673
Facet joint syndrome 144.66 9.46 9 166309 98380 90363749
Lip dry 143.30 9.46 11 166307 100944 90361185
Breast cancer stage III 140.21 9.46 3 166315 84444 90377685
Treatment failure 140.08 9.46 213 166105 303715 90158414
Drug intolerance 139.24 9.46 393 165925 447198 90014931
Psoriatic arthropathy 135.96 9.46 131 166187 228204 90233925
Lower respiratory tract infection 133.43 9.46 158 166160 250501 90211628
Product use in unapproved indication 132.72 9.46 260 166058 335976 90126153
Abdominal discomfort 132.20 9.46 442 165876 476886 89985243
Alopecia 132.00 9.46 466 165852 494605 89967524
Mobility decreased 129.29 9.46 162 166156 250572 90211557
Contraindicated product administered 126.83 9.46 247 166071 319892 90142237
Synovitis 125.02 9.46 261 166057 329491 90132638
Live birth 120.12 9.46 6 166312 79101 90383028
Hypertensive crisis 119.17 9.46 155 166163 17629 90444500
Asthma 119.16 9.46 162 166156 241998 90220131
Prescribed overdose 117.60 9.46 19 166299 97606 90364523
Heart rate decreased 116.99 9.46 285 166033 53220 90408909
Grip strength decreased 116.16 9.46 16 166302 92560 90369569
Autoimmune disorder 115.96 9.46 6 166312 76738 90385391
Haematocrit decreased 113.85 9.46 243 166075 41589 90420540
Drug ineffective 113.03 9.46 1826 164492 1382472 89079657
Hypersensitivity 110.75 9.46 444 165874 454233 90007896
Peripheral venous disease 108.93 9.46 13 166305 83908 90378221
Impaired healing 108.00 9.46 164 166154 234035 90228094
Wound infection 107.30 9.46 31 166287 106371 90355758
Blood pressure increased 102.98 9.46 667 165651 196550 90265579
Hepatic enzyme increased 102.60 9.46 330 165988 360406 90101723
Therapeutic product effect incomplete 100.22 9.46 125 166193 193771 90268358
Intervertebral discitis 98.45 9.46 75 166243 4445 90457684
Neovascularisation 96.64 9.46 51 166267 1579 90460550
Shock 94.81 9.46 181 166137 28597 90433532
Bursitis 94.02 9.46 63 166255 131591 90330538
Rheumatoid factor positive 93.69 9.46 106 166212 171544 90290585
Arthropathy 92.75 9.46 352 165966 365890 90096239
Blood creatinine increased 92.36 9.46 400 165918 100986 90361143
Haemoglobin decreased 91.54 9.46 559 165759 161397 90300732
Sinusitis 90.65 9.46 324 165994 342764 90119365
Joint range of motion decreased 90.22 9.46 70 166248 135573 90326556
Obesity 89.05 9.46 41 166277 105466 90356663
Red blood cell count decreased 88.94 9.46 235 166083 46116 90416013
Hyperkalaemia 88.88 9.46 292 166026 64672 90397457
Dizziness 87.17 9.46 1542 164776 587742 89874387
Loss of employment 86.68 9.46 59 166259 2928 90459201
Blood urea increased 86.63 9.46 180 166138 30233 90431896
Pyrexia 86.63 9.46 785 165533 659700 89802429
Blood glucose increased 86.16 9.46 375 165943 94871 90367258
Transient ischaemic attack 86.01 9.46 222 166096 42954 90419175
Gastrointestinal disorder 85.29 9.46 218 166100 256469 90205660
Acute myocardial infarction 85.13 9.46 194 166124 34696 90427433
International normalised ratio increased 83.88 9.46 233 166085 47083 90415046
Hypercholesterolaemia 82.40 9.46 41 166277 100851 90361278
Ulcer 81.53 9.46 184 166134 32698 90429431
Angina unstable 79.64 9.46 81 166237 7062 90455067
Demyelination 79.49 9.46 86 166232 8054 90454075
Sleep disorder 78.19 9.46 153 166165 197877 90264252
Night sweats 77.64 9.46 73 166245 128693 90333436
Feeling abnormal 77.36 9.46 549 165769 166686 90295443
Post-traumatic stress disorder 77.17 9.46 78 166240 6750 90455379
Blepharospasm 76.04 9.46 7 166311 55438 90406691
Product complaint 75.81 9.46 108 166210 13392 90448737
Hepatic steatosis 74.67 9.46 191 166127 36754 90425375
Myalgia 74.20 9.46 563 165755 174562 90287567
Product use issue 73.00 9.46 334 165984 329585 90132544
Therapeutic product effect decreased 72.05 9.46 264 166054 277307 90184822
Temperature intolerance 71.65 9.46 99 166219 11931 90450198
Blood pressure systolic increased 70.83 9.46 252 166066 58093 90404036
Diabetes mellitus 68.58 9.46 268 166050 64607 90397522
Onychomadesis 68.24 9.46 4 166314 45994 90416135
Myelosuppression 67.85 9.46 9 166309 53582 90408547
Blood glucose decreased 64.79 9.46 137 166181 23292 90438837
Bone erosion 64.57 9.46 10 166308 53011 90409118
Lung disorder 64.33 9.46 110 166208 149773 90312356
Liver function test increased 64.17 9.46 38 166280 84817 90377312
Hyperhidrosis 62.76 9.46 447 165871 135858 90326271
Lactic acidosis 61.29 9.46 218 166100 50245 90411884
Loss of consciousness 61.18 9.46 454 165864 139784 90322345
Palpitations 59.85 9.46 443 165875 136285 90325844
Hypokalaemia 58.06 9.46 426 165892 130690 90331439
Coordination abnormal 58.04 9.46 124 166194 21232 90440897
Hip arthroplasty 57.80 9.46 34 166284 76174 90385955
Injury 57.12 9.46 179 166139 197170 90264959
Granuloma skin 56.41 9.46 83 166235 10597 90451532
Joint swelling 56.38 9.46 621 165697 502679 89959450
Post cholecystectomy syndrome 56.34 9.46 29 166289 852 90461277
Femur fracture 55.90 9.46 199 166119 45883 90416246
Blood cholesterol increased 55.85 9.46 195 166123 207817 90254312
Lower limb fracture 55.10 9.46 45 166273 84968 90377161
Anuria 54.84 9.46 98 166220 14720 90447409
Sinus arrest 54.36 9.46 39 166279 2107 90460022
Rhabdomyolysis 53.57 9.46 211 166107 51045 90411084
Taste disorder 53.37 9.46 23 166295 61523 90400606
Frustration tolerance decreased 53.18 9.46 69 166249 7827 90454302
Pregnancy 52.52 9.46 24 166294 62023 90400106
Balance disorder 51.65 9.46 330 165988 96750 90365379
Hyperlipidaemia 51.08 9.46 123 166195 22793 90439336
Exposure via ingestion 51.04 9.46 41 166277 2626 90459503
Coronary arterial stent insertion 50.86 9.46 42 166276 2798 90459331
Cardiomegaly 50.41 9.46 109 166209 18816 90443313
C-reactive protein abnormal 49.81 9.46 99 166219 127330 90334799
Nail disorder 49.76 9.46 23 166295 59044 90403085
Breath sounds abnormal 49.73 9.46 96 166222 15290 90446839
Blood parathyroid hormone decreased 49.39 9.46 84 166234 12132 90449997
Knee arthroplasty 49.15 9.46 48 166270 83134 90378995
Device expulsion 49.14 9.46 8 166310 40878 90421251
Blood immunoglobulin A increased 48.70 9.46 30 166288 1253 90460876
Atrioventricular block first degree 47.66 9.46 68 166250 8443 90453686
Asthenia 47.52 9.46 1299 165019 532452 89929677
Gait inability 47.38 9.46 126 166192 146330 90315799
Urinary tract infection 46.93 9.46 805 165513 304827 90157302
Coeliac disease 46.84 9.46 12 166306 44598 90417531
Weight increased 46.65 9.46 516 165802 417411 90044718
Melaena 46.33 9.46 155 166163 34642 90427487
Carbuncle 45.60 9.46 30 166288 1406 90460723
Overdose 45.47 9.46 466 165852 157243 90304886
Blood pressure inadequately controlled 44.46 9.46 56 166262 6168 90455961
Atrioventricular block complete 44.43 9.46 71 166247 9740 90452389
Ventricular hypertrophy 44.42 9.46 42 166276 3349 90458780
Lipase increased 44.39 9.46 76 166242 11035 90451094
Panniculitis 44.05 9.46 88 166230 14370 90447759
Basal cell carcinoma 43.81 9.46 148 166170 33241 90428888
Alanine aminotransferase increased 43.32 9.46 368 165950 117970 90344159
Nausea 43.12 9.46 2468 163850 1107848 89354281
Paradoxical drug reaction 42.98 9.46 53 166265 5713 90456416
Colitis ulcerative 42.80 9.46 29 166289 60237 90401892
Rash 42.59 9.46 1124 165194 794976 89667153
Blood pressure decreased 42.59 9.46 259 166059 74636 90387493
Vision blurred 42.52 9.46 347 165971 109946 90352183
Epilepsy 42.45 9.46 53 166265 82153 90379976
Lethargy 42.24 9.46 228 166090 62911 90399218
Skin necrosis 42.22 9.46 95 166223 16846 90445283
Vitamin B12 deficiency 42.20 9.46 60 166258 7426 90454703
Condition aggravated 42.03 9.46 805 165513 594740 89867389
Vulvovaginal burning sensation 41.59 9.46 36 166282 2559 90459570
Skin ulcer 41.40 9.46 192 166126 49883 90412246
Laryngitis 40.87 9.46 21 166297 50732 90411397
Angina pectoris 40.75 9.46 161 166157 38999 90423130
Hypoglycaemia 40.65 9.46 243 166075 69605 90392524
Haemodialysis 40.57 9.46 64 166254 8683 90453446
Aspartate aminotransferase 40.49 9.46 22 166296 723 90461406
Progressive multifocal leukoencephalopathy 40.37 9.46 89 166229 15566 90446563
Multiple fractures 40.32 9.46 67 166251 9495 90452634
Arrhythmia 40.06 9.46 169 166149 42163 90419966
Hypomagnesaemia 40.06 9.46 150 166168 35438 90426691
Road traffic accident 40.04 9.46 86 166232 107540 90354589
Neoplasm skin 39.42 9.46 38 166280 3104 90459025
Body height decreased 39.17 9.46 75 166243 11874 90450255
Granulocyte count increased 39.14 9.46 28 166290 1506 90460623
Vitamin B12 increased 39.11 9.46 30 166288 1796 90460333
Coronary artery occlusion 38.87 9.46 62 166256 8492 90453637
Incorrect route of product administration 37.81 9.46 23 166295 50603 90411526
Rheumatoid factor increased 37.74 9.46 33 166285 2378 90459751
Aspartate aminotransferase increased 37.62 9.46 320 165998 102617 90359512
Atrioventricular block 37.48 9.46 62 166256 8753 90453376
Onychomycosis 37.47 9.46 11 166307 37365 90424764
Rectal polyp 37.18 9.46 24 166294 1089 90461040
Overweight 37.10 9.46 50 166268 5884 90456245
Fibrosis 36.99 9.46 50 166268 5902 90456227
Arteriosclerosis 36.66 9.46 69 166249 10784 90451345
Drug resistance 36.50 9.46 6 166312 30443 90431686
Cough 36.28 9.46 910 165408 368052 90094077
Urticaria 36.12 9.46 383 165935 312351 90149778
Metabolic acidosis 35.86 9.46 199 166119 55477 90406652
Depressed level of consciousness 35.43 9.46 242 166076 72542 90389587
Poisoning 35.35 9.46 83 166235 15134 90446995
Inflammation 35.32 9.46 188 166130 178404 90283725
Blood pressure diastolic decreased 35.28 9.46 119 166199 26707 90435422
Frequent bowel movements 34.64 9.46 32 166286 56903 90405226
Rhinalgia 34.55 9.46 32 166286 2486 90459643
Pulmonary oedema 34.24 9.46 213 166105 61867 90400262
Product substitution issue 34.23 9.46 91 166227 17917 90444212
Somnolence 34.01 9.46 556 165762 208528 90253601
Glomerular filtration rate increased 33.87 9.46 29 166289 2031 90460098
Sleep disorder due to a general medical condition 33.87 9.46 20 166298 44718 90417411
Chest pain 33.72 9.46 796 165522 318849 90143280
Hypercalcaemia 33.42 9.46 138 166180 34102 90428027
Blood sodium decreased 33.28 9.46 119 166199 27494 90434635
Erdheim-Chester disease 33.00 9.46 10 166308 65 90462064
Premature delivery 32.80 9.46 15 166303 38747 90423382
Cardiac failure 32.73 9.46 326 165992 109170 90352959
Jaundice 32.49 9.46 132 166186 32385 90429744
Presyncope 32.48 9.46 130 166188 31675 90430454
Hepatic cirrhosis 32.43 9.46 41 166277 63212 90398917
Sciatica 32.20 9.46 88 166230 101294 90360835
Vertigo 32.15 9.46 229 166089 69582 90392547
Respiratory depression 31.96 9.46 81 166237 15494 90446635
Epistaxis 31.83 9.46 266 166052 84859 90377270
Dysphagia 31.52 9.46 330 165988 111948 90350181
Emotional distress 31.37 9.46 142 166176 36520 90425609
Change of bowel habit 31.30 9.46 29 166289 2254 90459875
Pain 31.18 9.46 1503 164815 994838 89467291
Febrile neutropenia 31.13 9.46 167 166151 158182 90303947
Multiple sclerosis 31.05 9.46 117 166201 27723 90434406
Ventricular fibrillation 30.89 9.46 75 166243 13969 90448160
Dilatation atrial 30.78 9.46 27 166291 1954 90460175
Cardiac arrest 30.68 9.46 311 166007 104624 90357505
Throat irritation 30.67 9.46 173 166145 48522 90413607
Fear 30.59 9.46 83 166235 16539 90445590
Vulvovaginal pruritus 30.24 9.46 37 166281 3956 90458173
Fear of eating 29.90 9.46 15 166303 417 90461712
Hypothalamo-pituitary disorder 29.71 9.46 28 166290 2224 90459905
Oedema peripheral 29.60 9.46 650 165668 257265 90204864
Pancreatitis acute 29.45 9.46 127 166191 31988 90430141
Cardiac disorder 29.43 9.46 192 166126 56680 90405449
Joint noise 29.23 9.46 42 166276 5248 90456881
Monoclonal immunoglobulin present 29.16 9.46 27 166291 2097 90460032
Diarrhoea 28.75 9.46 2046 164272 937144 89524985
Chronic kidney disease 28.17 9.46 173 166145 50018 90412111
Blood potassium increased 28.13 9.46 93 166225 20656 90441473
Depressed mood 28.12 9.46 173 166145 50049 90412080
BRASH syndrome 27.98 9.46 25 166293 1854 90460275
Gallbladder disorder 27.97 9.46 90 166228 19713 90442416
Haemorrhoids 27.96 9.46 110 166208 26592 90435537
Maternal exposure timing unspecified 27.93 9.46 4 166314 22479 90439650
Lupus-like syndrome 27.93 9.46 29 166289 48817 90413312
Blood alkaline phosphatase increased 27.80 9.46 167 166151 47912 90414217
Duodenal ulcer 27.75 9.46 57 166261 9495 90452634
Bradyarrhythmia 27.60 9.46 28 166290 2433 90459696
Myocardial ischaemia 27.48 9.46 71 166247 13743 90448386
Renal cyst 27.26 9.46 68 166250 12882 90449247
Musculoskeletal stiffness 27.09 9.46 382 165936 296150 90165979
Hospitalisation 26.93 9.46 132 166186 127968 90334161
Vitamin D deficiency 26.83 9.46 82 166236 17474 90444655
Renal artery stenosis 26.70 9.46 26 166292 2151 90459978
Nodal rhythm 26.69 9.46 24 166294 1794 90460335
Ear infection 26.59 9.46 55 166263 69720 90392409
Back pain 26.24 9.46 765 165553 316410 90145719
Contusion 26.11 9.46 315 166003 250901 90211228
Liver function test abnormal 25.91 9.46 171 166147 50674 90411455
Therapy non-responder 25.87 9.46 146 166172 136558 90325571
Sinus node dysfunction 25.66 9.46 40 166278 5372 90456757
Blood creatine phosphokinase increased 25.62 9.46 127 166191 33896 90428233
Blood pressure fluctuation 25.35 9.46 174 166144 52239 90409890
Walking aid user 25.33 9.46 17 166301 35489 90426640
Oedema 25.31 9.46 240 166078 200055 90262074
Gastrointestinal haemorrhage 25.21 9.46 265 166053 89983 90372146
Lacunar infarction 25.11 9.46 31 166287 3346 90458783
Coronary artery bypass 25.03 9.46 26 166292 2323 90459806
Phaeochromocytoma 24.89 9.46 15 166303 602 90461527
Pulmonary embolism 24.77 9.46 357 165961 130463 90331666
Entropion 24.76 9.46 9 166309 109 90462020
Carotid artery stenosis 24.70 9.46 39 166279 5295 90456834
Urinary incontinence 24.68 9.46 135 166183 37431 90424698
Laryngotracheal oedema 24.64 9.46 7 166311 35 90462094
Blood triglycerides increased 24.62 9.46 68 166250 13693 90448436
Blood pressure immeasurable 24.52 9.46 21 166297 1471 90460658
Dyslipidaemia 24.43 9.46 56 166262 10051 90452078
Confusion postoperative 24.37 9.46 11 166307 240 90461889
Inappropriate antidiuretic hormone secretion 24.31 9.46 85 166233 19420 90442709
COVID-19 24.13 9.46 196 166122 168647 90293482
Bone disorder 24.01 9.46 95 166223 23025 90439104
Blood potassium decreased 24.01 9.46 160 166158 47567 90414562
Device dislocation 23.94 9.46 14 166304 31468 90430661
Mitral valve incompetence 23.76 9.46 93 166225 22431 90439698
Unresponsive to stimuli 23.72 9.46 135 166183 37986 90424143
Migraine 23.69 9.46 229 166089 190163 90271966
Skin neoplasm excision 23.59 9.46 22 166296 1724 90460405
Rheumatoid nodule 23.53 9.46 86 166232 20080 90442049
Drug dispensed to wrong patient 23.49 9.46 12 166306 347 90461782
Cholelithiasis 23.46 9.46 171 166147 52335 90409794
Nephropathy 23.25 9.46 52 166266 9183 90452946
Peripheral coldness 23.24 9.46 67 166251 13825 90448304
Upper respiratory tract infection 23.24 9.46 139 166179 128179 90333950
Circulatory collapse 23.23 9.46 99 166219 24805 90437324
Malignant neoplasm progression 23.12 9.46 109 166209 106761 90355368
Tremor 22.96 9.46 402 165916 152771 90309358
Foetal exposure during pregnancy 22.93 9.46 27 166291 42948 90419181
Disorientation 22.87 9.46 149 166169 43965 90418164
Diverticulum 22.81 9.46 61 166257 12052 90450077
Kidney small 22.59 9.46 10 166308 208 90461921
Illness anxiety disorder 22.55 9.46 9 166309 143 90461986
Rectosigmoid cancer 22.50 9.46 10 166308 210 90461919
Purple glove syndrome 22.41 9.46 10 166308 212 90461917
Intestinal ischaemia 22.34 9.46 50 166268 8833 90453296
Stoma site haemorrhage 22.33 9.46 19 166299 1319 90460810
Angioedema 22.30 9.46 199 166119 64677 90397452
Peripheral swelling 22.08 9.46 583 165735 412523 90049606
Urine odour abnormal 21.96 9.46 44 166274 7200 90454929
Hot flush 21.77 9.46 185 166133 59303 90402826
Ageusia 21.75 9.46 72 166246 16004 90446125
Dysgeusia 21.69 9.46 168 166150 52392 90409737
Bronchiectasis 21.61 9.46 7 166311 22323 90439806
Nervousness 21.45 9.46 121 166197 33935 90428194
Rash pruritic 21.38 9.46 238 166080 81976 90380153
Adverse drug reaction 21.35 9.46 126 166192 116575 90345554
Atrioventricular block second degree 21.24 9.46 33 166285 4419 90457710
Miosis 21.24 9.46 51 166267 9433 90452696
Hip fracture 21.15 9.46 118 166200 32959 90429170
Coronary artery stenosis 21.01 9.46 36 166282 5230 90456899
Anhedonia 20.96 9.46 57 166261 11374 90450755
Hallucination, visual 20.93 9.46 91 166227 23001 90439128
Arteriosclerosis coronary artery 20.82 9.46 51 166267 9552 90452577
Respiratory disorder 20.77 9.46 56 166262 64760 90397369
Cerebral haematoma 20.75 9.46 32 166286 4257 90457872
Skull fracture 20.70 9.46 18 166300 1287 90460842
Hypoaesthesia 20.53 9.46 430 165888 313780 90148349
Female genital tract fistula 20.38 9.46 4 166314 17864 90444265
Extrapyramidal disorder 20.28 9.46 71 166247 16232 90445897
Cyanosis 20.25 9.46 80 166238 19375 90442754
Mental status changes postoperative 20.25 9.46 9 166309 189 90461940
Phaeochromocytoma crisis 20.23 9.46 11 166307 362 90461767
Adverse reaction 20.17 9.46 15 166303 29697 90432432
Cerebral haemorrhage 20.02 9.46 120 166198 34402 90427727
Wrist deformity 19.82 9.46 27 166291 3211 90458918
Anaemia 19.65 9.46 813 165505 351989 90110140
Swelling face 19.59 9.46 232 166086 81120 90381009
Memory impairment 19.48 9.46 250 166068 196994 90265135
Red blood cell sedimentation rate abnormal 19.41 9.46 92 166226 24112 90438017
Bundle branch block left 19.41 9.46 44 166274 7841 90454288
Gingival hypertrophy 19.34 9.46 22 166296 2178 90459951
Polyp 19.20 9.46 43 166275 7601 90454528
Cytokine release syndrome 19.15 9.46 14 166304 27959 90434170
Deafness 19.11 9.46 87 166231 22427 90439702
Sinus arrhythmia 19.08 9.46 18 166300 1431 90460698
Thyroid atrophy 19.06 9.46 10 166308 306 90461823
Throat clearing 19.04 9.46 29 166289 3818 90458311
Blood uric acid increased 18.97 9.46 43 166275 7661 90454468
Dactylitis 18.89 9.46 29 166289 3844 90458285
Retinal vein thrombosis 18.86 9.46 12 166306 531 90461598
Blood chloride decreased 18.70 9.46 38 166280 6281 90455848
Glycosylated haemoglobin increased 18.70 9.46 67 166251 15495 90446634
Laryngeal pain 18.67 9.46 31 166287 4391 90457738
Pain in extremity 18.65 9.46 1008 165310 449521 90012608
Abortion spontaneous 18.64 9.46 45 166273 54011 90408118
Sopor 18.56 9.46 92 166226 24552 90437577
Burning sensation 18.52 9.46 188 166130 63264 90398865
Musculoskeletal discomfort 18.48 9.46 82 166236 20909 90441220
Coma scale normal 18.45 9.46 4 166314 4 90462125
Ultrasound kidney abnormal 18.40 9.46 6 166312 51 90462078
Delirium 18.39 9.46 114 166204 104245 90357884
Hyperglycaemia 18.38 9.46 158 166160 50812 90411317
Infusion site reaction 18.37 9.46 6 166312 19033 90443096
Proctalgia 18.27 9.46 44 166274 8154 90453975
Ulcer haemorrhage 18.24 9.46 13 166305 26308 90435821
Limb discomfort 18.19 9.46 126 166192 37934 90424195
Increased appetite 18.02 9.46 55 166263 11710 90450419
Muscle spasticity 18.00 9.46 23 166295 35299 90426830
Dysuria 17.99 9.46 129 166189 39272 90422857
Pseudopolyposis 17.94 9.46 5 166313 23 90462106
Injection site discomfort 17.91 9.46 36 166282 5904 90456225
Electrocardiogram QRS complex abnormal 17.88 9.46 9 166309 252 90461877
Rash pustular 17.72 9.46 43 166275 8006 90454123
Resorption bone increased 17.72 9.46 16 166302 1203 90460926
Cardiac flutter 17.58 9.46 31 166287 4607 90457522
Dysphonia 17.50 9.46 185 166133 62899 90399230
Purpura senile 17.50 9.46 12 166306 603 90461526
Cardiogenic shock 17.49 9.46 90 166228 24378 90437751
Immunodeficiency 17.40 9.46 33 166285 43201 90418928
Cytomegalovirus infection 17.34 9.46 14 166304 26588 90435541
Intentional product misuse 17.33 9.46 95 166223 89509 90372620
Vaginal discharge 17.31 9.46 7 166311 19457 90442672
Furuncle 17.30 9.46 41 166277 7520 90454609
Temperature regulation disorder 17.19 9.46 3 166315 14576 90447553
Food allergy 17.12 9.46 13 166305 25465 90436664
Rash vesicular 17.10 9.46 6 166312 18191 90443938
Cataract 17.09 9.46 205 166113 71887 90390242
Torsade de pointes 17.09 9.46 64 166254 15118 90447011
Visceral congestion 17.09 9.46 10 166308 380 90461749
Injection site reaction 17.06 9.46 99 166219 91981 90370148
Peak expiratory flow rate decreased 17.03 9.46 12 166306 630 90461499
Neurofibrosarcoma 17.02 9.46 8 166310 192 90461937
Intracranial haematoma 16.85 9.46 10 166308 390 90461739
Blood pressure systolic decreased 16.77 9.46 46 166272 9224 90452905
Renal injury 16.75 9.46 49 166269 10194 90451935
Ventricular extrasystoles 16.74 9.46 58 166260 13192 90448937
Product residue present 16.68 9.46 29 166289 4262 90457867
Visual acuity reduced 16.66 9.46 86 166232 23324 90438805
Colon cancer 16.61 9.46 51 166267 10893 90451236
Osteoarthritis 16.52 9.46 256 166062 195474 90266655
Spinal disorder 16.42 9.46 53 166265 11626 90450503
Cystocele 16.39 9.46 17 166301 1517 90460612
Lung diffusion test decreased 16.38 9.46 13 166305 818 90461311
Cholecystitis acute 16.36 9.46 46 166272 9358 90452771
Laryngospasm 16.31 9.46 25 166293 3308 90458821
Pancreatitis 16.31 9.46 198 166120 69628 90392501
Nephrogenic systemic fibrosis 16.28 9.46 28 166290 4080 90458049
Intramedullary rod insertion 16.25 9.46 20 166298 2152 90459977
Forced vital capacity decreased 16.22 9.46 15 166303 1163 90460966
Toxicity to various agents 16.17 9.46 664 165654 287182 90174947
High density lipoprotein decreased 16.06 9.46 22 166296 2629 90459500
Acute coronary syndrome 16.05 9.46 50 166268 10763 90451366
Pernicious anaemia 16.04 9.46 13 166305 843 90461286
Neutrophil count decreased 16.04 9.46 72 166246 71460 90390669
Cytopenia 15.98 9.46 6 166312 17443 90444686
Intestinal haemorrhage 15.93 9.46 29 166289 4418 90457711
Back injury 15.93 9.46 39 166279 46583 90415546
Heart rate irregular 15.80 9.46 87 166231 24181 90437948
Vulvovaginal discomfort 15.77 9.46 22 166296 2675 90459454
Breast calcifications 15.76 9.46 16 166302 1392 90460737
Weight decreased 15.71 9.46 850 165468 379060 90083069
Gastric ulcer 15.65 9.46 95 166223 27353 90434776
Intervertebral disc degeneration 15.60 9.46 68 166250 17206 90444923
Purpura 15.57 9.46 61 166257 14717 90447412
Contrast media reaction 15.45 9.46 15 166303 1236 90460893
Depression 15.45 9.46 687 165631 299914 90162215
Cerebral ischaemia 15.37 9.46 38 166280 7158 90454971
General symptom 15.29 9.46 4 166314 14664 90447465
Renal tubular acidosis 15.23 9.46 20 166298 2295 90459834
Dysstasia 15.11 9.46 88 166230 24964 90437165
Adenocarcinoma of colon 15.10 9.46 22 166296 2784 90459345
Skin disorder 14.97 9.46 117 166201 36589 90425540
Supraventricular extrasystoles 14.84 9.46 31 166287 5226 90456903
Blood catecholamines decreased 14.80 9.46 4 166314 16 90462113
Ischaemic stroke 14.79 9.46 80 166238 22086 90440043
Head injury 14.76 9.46 103 166215 31085 90431044
Blood osmolarity decreased 14.76 9.46 13 166305 946 90461183
Glomerulonephritis acute 14.71 9.46 6 166312 101 90462028
Electrolyte imbalance 14.71 9.46 84 166234 23661 90438468
Gastric ulcer haemorrhage 14.62 9.46 31 166287 5280 90456849
Full blood count decreased 14.61 9.46 99 166219 29590 90432539
Haemorrhagic vasculitis 14.61 9.46 6 166312 103 90462026
Hypothermia 14.60 9.46 62 166256 15513 90446616
Aspartate aminotransferase abnormal 14.59 9.46 21 166297 2628 90459501
Haemorrhoidal haemorrhage 14.57 9.46 31 166287 5292 90456837
Renal impairment 14.50 9.46 273 166045 105148 90356981
Electrocardiogram ST-T change 14.46 9.46 13 166305 972 90461157
Osteonecrosis 14.44 9.46 90 166228 26151 90435978
Extrasystoles 14.41 9.46 32 166286 5625 90456504
Prothrombin time prolonged 14.34 9.46 45 166273 9727 90452402
Cerebellar haematoma 14.29 9.46 9 166309 391 90461738
Needle issue 14.27 9.46 57 166261 13877 90448252
Fasting 14.25 9.46 4 166314 19 90462110
Orthostatic hypotension 14.22 9.46 128 166190 41699 90420430
Tinnitus 14.20 9.46 131 166187 42971 90419158
Impaired quality of life 14.09 9.46 13 166305 23131 90438998
Drug abuse 13.97 9.46 91 166227 82256 90379873
Urine glucose/creatinine ratio increased 13.94 9.46 7 166311 195 90461934
Haematotoxicity 13.89 9.46 3 166315 12532 90449597
Diastolic dysfunction 13.88 9.46 37 166281 7296 90454833
Cardiac valve disease 13.87 9.46 28 166290 4607 90457522
Autoimmune nephritis 13.85 9.46 9 166309 413 90461716
Disease progression 13.85 9.46 203 166115 156412 90305717
Pharyngeal oedema 13.83 9.46 56 166262 13715 90448414
Postoperative wound infection 13.81 9.46 55 166263 13371 90448758
Cardiac neoplasm unspecified 13.80 9.46 5 166313 60 90462069
Thyrotoxic crisis 13.80 9.46 14 166304 1217 90460912
Neuropathy peripheral 13.78 9.46 339 165979 136631 90325498
Aortic aneurysm 13.78 9.46 27 166291 4348 90457781
Peau d'orange 13.77 9.46 6 166312 120 90462009
Supraventricular tachycardia 13.77 9.46 63 166255 16273 90445856
Limb injury 13.72 9.46 102 166216 31406 90430723
Nasal discomfort 13.70 9.46 31 166287 5517 90456612
Microgenia 13.61 9.46 4 166314 23 90462106
Nasal dryness 13.57 9.46 31 166287 5552 90456577
Vertigo positional 13.53 9.46 23 166295 3321 90458808
Tarsal tunnel syndrome 13.51 9.46 10 166308 567 90461562
Staring 13.51 9.46 16 166302 1654 90460475
Bone infarction 13.51 9.46 9 166309 431 90461698
International normalised ratio decreased 13.50 9.46 28 166290 4696 90457433
Monoclonal B-cell lymphocytosis 13.50 9.46 7 166311 209 90461920
Monocyte count increased 13.45 9.46 42 166276 9055 90453074
Drug eruption 13.42 9.46 111 166207 35296 90426833
Halo vision 13.38 9.46 9 166309 438 90461691
Dermatitis 13.37 9.46 78 166240 22142 90439987
Cutaneous lupus erythematosus 13.35 9.46 22 166296 3096 90459033
Pollakiuria 13.34 9.46 105 166213 32900 90429229
Hypophagia 13.27 9.46 112 166206 35825 90426304
Yawning 13.11 9.46 13 166305 1099 90461030
Device difficult to use 13.03 9.46 8 166310 17517 90444612
Cardiac stress test abnormal 13.02 9.46 10 166308 600 90461529
Ear pain 12.99 9.46 58 166260 57644 90404485
Continuous haemodiafiltration 12.97 9.46 12 166306 931 90461198
IIIrd nerve paresis 12.80 9.46 6 166312 143 90461986
Spinal osteoarthritis 12.70 9.46 69 166249 19079 90443050
Rheumatoid arthritis 12.70 9.46 540 165778 362074 90100055
Insulin-like growth factor increased 12.64 9.46 12 166306 962 90461167
Gilbert's syndrome 12.62 9.46 3 166315 6 90462123
Hypocalcaemia 12.59 9.46 126 166192 42242 90419887
Low density lipoprotein increased 12.58 9.46 38 166280 8047 90454082
COVID-19 pneumonia 12.57 9.46 9 166309 18168 90443961
Economic problem 12.53 9.46 22 166296 3259 90458870
White blood cells urine positive 12.52 9.46 33 166285 6465 90455664
Dysdiadochokinesis 12.47 9.46 6 166312 152 90461977
Paranasal sinus discomfort 12.44 9.46 32 166286 6178 90455951
Plasma cell myeloma 12.41 9.46 122 166196 40706 90421423
Mental status changes 12.38 9.46 131 166187 44548 90417581
Vascular access site pain 12.37 9.46 9 166309 497 90461632
Mass 12.34 9.46 59 166259 15518 90446611
Coma scale abnormal 12.33 9.46 30 166288 5596 90456533
Renal artery fibromuscular dysplasia 12.31 9.46 3 166315 7 90462122
Hypersensitivity vasculitis 12.30 9.46 25 166293 4134 90457995
Hiatus hernia 12.15 9.46 84 166234 25277 90436852
Hypertension 12.14 9.46 986 165332 456546 90005583
Infusion site pain 12.12 9.46 11 166307 19727 90442402
Coma 12.12 9.46 194 166124 72438 90389691
Skin cancer 12.04 9.46 53 166265 13466 90448663
Pericardial haemorrhage 12.02 9.46 16 166302 1860 90460269
Product substitution error 11.97 9.46 4 166314 37 90462092
Electrocardiogram QT prolonged 11.89 9.46 193 166125 72263 90389866
Concussion 11.86 9.46 46 166272 11045 90451084
Injection site extravasation 11.85 9.46 40 166278 8979 90453150
Anxiety 11.81 9.46 688 165630 309084 90153045
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.80 9.46 24 166294 3969 90458160
Thyroid disorder 11.74 9.46 64 166254 17721 90444408
Peripheral vascular disorder 11.72 9.46 32 166286 6399 90455730
Muscle atrophy 11.70 9.46 38 166280 8363 90453766
Drug hypersensitivity 11.70 9.46 714 165604 462895 89999234
Haemophagocytic lymphohistiocytosis 11.58 9.46 7 166311 15452 90446677
Movement disorder 11.56 9.46 92 166226 28927 90433202
Female sexual arousal disorder 11.52 9.46 4 166314 42 90462087
Abdominal pain 11.51 9.46 859 165459 394862 90067267
Swollen tongue 11.48 9.46 132 166186 45824 90416305
Dyspnoea 11.46 9.46 1812 164506 879143 89582986
Adrenal insufficiency 11.45 9.46 94 166224 29827 90432302
Nodal arrhythmia 11.40 9.46 13 166305 1290 90460839
Ischaemia 11.35 9.46 28 166290 5267 90456862
Hypersomnia 11.33 9.46 73 166245 21458 90440671
Procedural pain 11.32 9.46 28 166290 33332 90428797
Hypertrophic cardiomyopathy 11.31 9.46 17 166301 2211 90459918
Mediastinal haemorrhage 11.31 9.46 3 166315 11 90462118
Dystrophic calcification 11.30 9.46 6 166312 188 90461941
Metabolic alkalosis 11.29 9.46 22 166296 3527 90458602
Nasal polyps 11.28 9.46 3 166315 10877 90451252
Colorectal adenocarcinoma 11.25 9.46 6 166312 190 90461939
International normalised ratio abnormal 11.23 9.46 23 166295 3822 90458307
Cerebral atrophy 11.21 9.46 29 166289 5617 90456512
Tubular breast carcinoma 11.19 9.46 4 166314 46 90462083
Azotaemia 11.17 9.46 28 166290 5320 90456809
Potentiating drug interaction 11.16 9.46 29 166289 5633 90456496
Central nervous system inflammation 11.10 9.46 6 166312 195 90461934
Pneumocystis jirovecii pneumonia 11.09 9.46 14 166304 21602 90440527
Foetal death 11.08 9.46 13 166305 20710 90441419
Respiration abnormal 11.07 9.46 36 166282 7927 90454202
Sensitisation 11.07 9.46 24 166294 4151 90457978
Saliva discolouration 11.04 9.46 4 166314 48 90462081
Blood urine 10.99 9.46 8 166310 442 90461687
Speech disorder 10.97 9.46 130 166188 45455 90416674
Chorioretinal disorder 10.95 9.46 5 166313 112 90462017
Quadriparesis 10.93 9.46 18 166300 2531 90459598
Post procedural complication 10.92 9.46 66 166252 18976 90443153
Gastritis 10.91 9.46 121 166197 41632 90420497
Low turnover osteopathy 10.90 9.46 24 166294 4194 90457935
Malaise 10.83 9.46 1231 165087 584755 89877374
Ventricular tachycardia 10.77 9.46 80 166238 24628 90437501
Hair growth abnormal 10.75 9.46 22 166296 3654 90458475
Vascular calcification 10.74 9.46 10 166308 782 90461347
Hypertransaminasaemia 10.73 9.46 8 166310 15817 90446312
Malabsorption 10.70 9.46 27 166291 5151 90456978
Abnormal dreams 10.69 9.46 45 166273 11212 90450917
Gout 10.68 9.46 60 166258 16799 90445330
Petechiae 10.63 9.46 57 166261 15684 90446445
Pustular psoriasis 10.63 9.46 11 166307 18545 90443584
Ischaemic cardiomyopathy 10.61 9.46 18 166300 2595 90459534
Cataract operation 10.58 9.46 30 166288 6133 90455996
Vasculitic rash 10.57 9.46 13 166305 1397 90460732
Ear, nose and throat examination abnormal 10.56 9.46 3 166315 15 90462114
Ventricular dysfunction 10.53 9.46 22 166296 3709 90458420
Hypovolaemia 10.52 9.46 48 166270 12383 90449746
Vitreous detachment 10.48 9.46 17 166301 2361 90459768
Accelerated hypertension 10.47 9.46 8 166310 476 90461653
Infective pulmonary exacerbation of cystic fibrosis 10.35 9.46 3 166315 10276 90451853
Vertebral lateral recess stenosis 10.33 9.46 7 166311 345 90461784
Weight loss poor 10.32 9.46 13 166305 1432 90460697
Cardio-respiratory arrest 10.29 9.46 168 166150 62972 90399157
Bone sequestrum 10.26 9.46 13 166305 1440 90460689
Lung neoplasm malignant 10.25 9.46 78 166240 24195 90437934
Pruritus 10.24 9.46 855 165463 540670 89921459
HIV-associated neurocognitive disorder 10.17 9.46 5 166313 133 90461996
Bone hyperpigmentation 10.10 9.46 3 166315 18 90462111
Lung infiltration 10.09 9.46 55 166263 15227 90446902
Female orgasmic disorder 10.05 9.46 4 166314 63 90462066
Osteoarthropathy 10.05 9.46 7 166311 361 90461768
Hypokinesia 10.04 9.46 56 166262 15641 90446488
Oesophagitis 10.03 9.46 60 166258 17189 90444940
Haemorrhage 10.01 9.46 181 166137 69188 90392941
Blood osmolarity increased 10.01 9.46 7 166311 363 90461766
Pulmonary thrombosis 10.00 9.46 40 166278 9742 90452387
Ecchymosis 10.00 9.46 47 166271 12276 90449853
Parathyroid hyperplasia 10.00 9.46 5 166313 138 90461991
Flatulence 9.97 9.46 118 166200 41249 90420880
Electrocardiogram PR prolongation 9.94 9.46 10 166308 860 90461269
Hepatitis acute 9.94 9.46 43 166275 10844 90451285
Coagulopathy 9.92 9.46 75 166243 23214 90438915
Stridor 9.91 9.46 25 166293 4768 90457361
Macular degeneration 9.91 9.46 36 166282 37934 90424195
Non-cardiac chest pain 9.91 9.46 31 166287 6690 90455439
Ligamentum flavum hypertrophy 9.89 9.46 7 166311 370 90461759
Urine abnormality 9.89 9.46 34 166284 7703 90454426
Postmortem blood drug level abnormal 9.84 9.46 6 166312 246 90461883
Urethritis noninfective 9.83 9.46 3 166315 20 90462109
Heavy menstrual bleeding 9.82 9.46 14 166304 20516 90441613
Lichen planus 9.75 9.46 18 166300 2773 90459356
Pickwickian syndrome 9.68 9.46 7 166311 383 90461746
No adverse event 9.67 9.46 79 166239 67903 90394226
Electrocardiogram abnormal 9.65 9.46 41 166277 10257 90451872
Therapy partial responder 9.61 9.46 16 166302 22027 90440102
Haemorrhagic stroke 9.61 9.46 30 166288 6466 90455663
Tricuspid valve incompetence 9.60 9.46 58 166260 16673 90445456
Foot deformity 9.58 9.46 67 166251 59584 90402545
Skin laceration 9.54 9.46 81 166237 25954 90436175
Rhythm idioventricular 9.54 9.46 7 166311 392 90461737
Gingival pain 9.50 9.46 39 166279 9613 90452516

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 604.12 10.53 877 101457 84607 42434394
Off label use 454.55 10.53 521 101813 637814 41881187
Myocardial infarction 335.63 10.53 845 101489 123164 42395837
Completed suicide 289.31 10.53 684 101650 95781 42423220
Sinus bradycardia 212.49 10.53 218 102116 14635 42504366
Coronary artery disease 200.53 10.53 416 101918 53304 42465697
Hypotension 178.73 10.53 1143 101191 256488 42262513
Product use in unapproved indication 164.09 10.53 122 102212 184334 42334667
Syncope 147.46 10.53 549 101785 98857 42420144
Cardiac failure congestive 143.39 10.53 492 101842 85110 42433891
Drug ineffective 137.11 10.53 920 101414 629277 41889724
Febrile neutropenia 117.24 10.53 165 102169 185538 42333463
COVID-19 100.08 10.53 79 102255 115869 42403132
Cerebrovascular accident 98.48 10.53 478 101856 96682 42422319
Angina unstable 94.91 10.53 127 102207 11321 42507680
Chest pain 93.37 10.53 614 101720 138916 42380085
Acute myocardial infarction 88.49 10.53 324 102010 57841 42461160
Angina pectoris 85.47 10.53 221 102113 32675 42486326
Condition aggravated 85.18 10.53 330 102004 260424 42258577
Rhabdomyolysis 81.32 10.53 387 101947 77632 42441369
Drug abuse 81.20 10.53 79 102255 104692 42414309
Dizziness 71.15 10.53 912 101422 248342 42270659
Death 69.66 10.53 760 101574 470425 42048576
Hyperkalaemia 69.09 10.53 378 101956 80080 42438921
Neutropenia 68.59 10.53 247 102087 199184 42319817
Intentional product use issue 68.45 10.53 44 102290 71789 42447212
Acute kidney injury 67.51 10.53 1247 101087 366090 42152911
Pyrexia 67.18 10.53 614 101720 393428 42125573
Orthostatic hypotension 62.28 10.53 188 102146 30382 42488619
Myelosuppression 62.22 10.53 11 102323 40450 42478551
Injury 59.08 10.53 151 102183 22165 42496836
Myocardial ischaemia 57.58 10.53 130 102204 17632 42501369
IgM nephropathy 57.34 10.53 19 102315 126 42518875
Foetal exposure during pregnancy 57.19 10.53 21 102313 47290 42471711
Coronary artery occlusion 56.95 10.53 98 102236 10899 42508102
Myalgia 54.91 10.53 407 101927 95673 42423328
Therapeutic product effect incomplete 54.36 10.53 54 102280 70885 42448116
Cytokine release syndrome 53.42 10.53 20 102314 44507 42474494
Atrioventricular block first degree 52.26 10.53 71 102263 6420 42512581
Coronary artery bypass 52.08 10.53 61 102273 4749 42514252
Treatment failure 51.13 10.53 45 102289 62579 42456422
Coronary arterial stent insertion 49.03 10.53 54 102280 3931 42515070
Confusional state 48.92 10.53 616 101718 166981 42352020
Drug ineffective for unapproved indication 45.74 10.53 27 102307 46136 42472865
Asthenia 44.65 10.53 933 101401 279860 42239141
Blood pressure inadequately controlled 40.84 10.53 42 102292 2826 42516175
Circulatory collapse 39.64 10.53 136 102198 23500 42495501
Emotional distress 39.63 10.53 106 102228 15987 42503014
International normalised ratio increased 39.13 10.53 223 102111 47945 42471056
Drug resistance 38.45 10.53 17 102317 34231 42484770
Coordination abnormal 38.15 10.53 69 102265 7981 42511020
Sinus node dysfunction 37.78 10.53 52 102282 4760 42514241
Atrioventricular block complete 37.76 10.53 84 102250 11280 42507721
Loss of consciousness 36.29 10.53 360 101974 91994 42427007
Inappropriate schedule of product administration 36.18 10.53 114 102220 95788 42423213
Blood creatine phosphokinase increased 36.17 10.53 219 102115 48119 42470882
Hospitalisation 35.96 10.53 78 102256 74252 42444749
Drug intolerance 34.45 10.53 90 102244 80334 42438667
Atrioventricular block 34.14 10.53 73 102261 9542 42509459
Coronary artery stenosis 33.68 10.53 76 102258 10303 42508698
Blood glucose increased 32.79 10.53 295 102039 73404 42445597
Cardiac arrest 32.37 10.53 403 101931 108917 42410084
Shock 32.18 10.53 147 102187 28974 42490027
Product dose omission issue 31.95 10.53 228 102106 154137 42364864
Fear 30.91 10.53 76 102258 10889 42508112
Malignant spinal cord compression 30.83 10.53 12 102322 133 42518868
Anhedonia 30.65 10.53 61 102273 7579 42511422
Pneumonia 30.33 10.53 777 101557 421372 42097629
Electrocardiogram J wave 30.15 10.53 9 102325 40 42518961
Product complaint 29.31 10.53 52 102282 5925 42513076
Atrial fibrillation 29.13 10.53 484 101850 139109 42379892
Wrong drug 29.12 10.53 12 102322 156 42518845
Palpitations 28.89 10.53 215 102119 50582 42468419
Metabolic acidosis 28.66 10.53 218 102116 51640 42467361
Plasmapheresis 28.37 10.53 16 102318 429 42518572
Sepsis 28.32 10.53 324 102010 199010 42319991
Lethargy 28.12 10.53 201 102133 46689 42472312
Paraplegia 27.98 10.53 37 102297 3260 42515741
Paroxysmal atrioventricular block 27.78 10.53 6 102328 3 42518998
Pacemaker generated rhythm 26.99 10.53 9 102325 61 42518940
Renal failure 26.99 10.53 490 101844 143236 42375765
Pulmonary oedema 26.72 10.53 219 102115 53053 42465948
Nodal arrhythmia 26.69 10.53 20 102314 879 42518122
Diverticulum 26.48 10.53 57 102277 7484 42511517
Vasculitic rash 26.47 10.53 21 102313 1005 42517996
Disease progression 26.07 10.53 220 102114 143436 42375565
Transient ischaemic attack 25.97 10.53 154 102180 33585 42485416
General physical health deterioration 25.95 10.53 235 102099 151011 42367990
Asthma 25.72 10.53 71 102263 62243 42456758
Mucosal inflammation 24.55 10.53 51 102283 49323 42469678
Product use issue 24.43 10.53 98 102236 76653 42442348
Drop attacks 24.18 10.53 16 102318 575 42518426
Therapy partial responder 24.00 10.53 9 102325 20012 42498989
Heart rate decreased 23.92 10.53 160 102174 36372 42482629
Oedema peripheral 23.84 10.53 459 101875 135617 42383384
Hypovolaemia 23.73 10.53 71 102263 11414 42507587
Encapsulating peritoneal sclerosis 23.67 10.53 16 102318 596 42518405
Acute coronary syndrome 23.60 10.53 84 102250 14781 42504220
Renal injury 22.68 10.53 73 102261 12207 42506794
Swelling face 22.66 10.53 128 102206 27426 42491575
Presyncope 22.54 10.53 110 102224 22277 42496724
Leukopenia 22.21 10.53 98 102236 74648 42444353
Haemophagocytic lymphohistiocytosis 22.17 10.53 8 102326 18214 42500787
Dehydration 22.12 10.53 470 101864 141297 42377704
Neutrophil count decreased 22.11 10.53 78 102256 63337 42455664
Blood creatinine increased 22.06 10.53 379 101955 109624 42409377
Erectile dysfunction 22.00 10.53 118 102216 24795 42494206
Diabetic neuropathy 21.86 10.53 39 102295 4463 42514538
Infusion related reaction 21.74 10.53 74 102260 60732 42458269
Hypertension 21.64 10.53 540 101794 166664 42352337
Hypoglycaemia 21.44 10.53 229 102105 59625 42459376
Hepatitis 21.26 10.53 125 102209 27175 42491826
Drug interaction 21.14 10.53 812 101522 266187 42252814
Blood pressure increased 21.10 10.53 353 101981 101575 42417426
Graft versus host disease 21.03 10.53 3 102331 12922 42506079
COVID-19 pneumonia 20.91 10.53 13 102321 21600 42497401
Fall 20.70 10.53 722 101612 233798 42285203
Incorrect route of product administration 20.40 10.53 17 102317 24288 42494713
Antiacetylcholine receptor antibody positive 20.14 10.53 8 102326 94 42518907
Hypertensive crisis 20.06 10.53 62 102272 10144 42508857
Ventricular hypertrophy 19.98 10.53 39 102295 4777 42514224
Hyperglycaemia 19.60 10.53 182 102152 45677 42473324
Iron binding capacity total increased 19.53 10.53 6 102328 30 42518971
Tongue oedema 19.15 10.53 31 102303 3279 42515722
Cytomegalovirus infection 19.08 10.53 30 102304 32276 42486725
Guillain-Barre syndrome 19.07 10.53 49 102285 7214 42511787
Sleep disorder due to a general medical condition 19.07 10.53 9 102325 17444 42501557
Lactic acidosis 19.03 10.53 179 102155 45082 42473919
Cardio-respiratory arrest 19.02 10.53 220 102114 58416 42460585
Optic ischaemic neuropathy 18.86 10.53 28 102306 2747 42516254
Rheumatoid arthritis 18.54 10.53 47 102287 42393 42476608
Contraindicated product administered 18.49 10.53 20 102314 25252 42493749
Intentional product misuse 18.48 10.53 81 102253 61819 42457182
Potentiating drug interaction 18.41 10.53 45 102289 6423 42512578
Hyponatraemia 18.36 10.53 344 101990 101118 42417883
Anion gap abnormal 18.29 10.53 12 102322 425 42518576
Allergy to animal 18.05 10.53 13 102321 537 42518464
Influenza 17.58 10.53 83 102251 62092 42456909
End stage renal disease 17.39 10.53 9 102325 16549 42502452
Angioedema 17.36 10.53 167 102167 42310 42476691
Vascular graft 17.29 10.53 20 102314 1536 42517465
Dyskinesia oesophageal 17.25 10.53 6 102328 47 42518954
Cerebral haematoma 17.01 10.53 40 102294 5570 42513431
Hypomagnesaemia 17.01 10.53 122 102212 28366 42490635
Neurotoxicity 16.99 10.53 19 102315 23632 42495369
Pulse absent 16.94 10.53 43 102291 6284 42512717
Illness 16.87 10.53 21 102313 24909 42494092
C-reactive protein increased 16.74 10.53 87 102247 63473 42455528
Obstructive airways disorder 16.60 10.53 21 102313 24738 42494263
Anuria 16.49 10.53 63 102271 11469 42507532
Ultrasound Doppler abnormal 16.49 10.53 4 102330 6 42518995
Nasopharyngitis 16.44 10.53 126 102208 83870 42435131
Haemodialysis 16.31 10.53 58 102276 10202 42508799
Atrioventricular block second degree 16.28 10.53 33 102301 4154 42514847
Electrocardiogram QRS complex prolonged 16.03 10.53 40 102294 5783 42513218
Gastric ulcer 15.79 10.53 86 102248 18176 42500825
Toxic epidermal necrolysis 15.65 10.53 25 102309 26725 42492276
Thrombotic microangiopathy 15.58 10.53 8 102326 14774 42504227
Appendicitis 15.43 10.53 16 102318 20597 42498404
Abdominal compartment syndrome 15.40 10.53 16 102318 1089 42517912
Nail pigmentation 15.40 10.53 7 102327 117 42518884
Retinal infarction 15.29 10.53 7 102327 119 42518882
Hypophagia 15.27 10.53 114 102220 26842 42492159
Blood pressure immeasurable 15.17 10.53 15 102319 963 42518038
Abnormal dreams 15.12 10.53 49 102285 8222 42510779
Ischaemic cardiomyopathy 15.10 10.53 42 102292 6480 42512521
Immune reconstitution inflammatory syndrome 15.07 10.53 3 102331 10140 42508861
Cardiogenic shock 15.00 10.53 141 102193 35499 42483502
Mitral valve incompetence 14.49 10.53 78 102256 16411 42502590
Azotaemia 14.48 10.53 39 102295 5905 42513096
Malignant neoplasm progression 14.30 10.53 179 102155 108221 42410780
Melaena 14.23 10.53 149 102185 38597 42480404
Hiatus hernia 14.13 10.53 49 102285 8511 42510490
Sinoatrial block 14.09 10.53 11 102323 514 42518487
Blood cholesterol increased 13.98 10.53 111 102223 26630 42492371
Neuropathy peripheral 13.88 10.53 167 102167 101686 42417315
Haemorrhagic stroke 13.66 10.53 44 102290 7358 42511643
Electrocardiogram QRS complex shortened 13.65 10.53 8 102326 231 42518770
Anxiety 13.62 10.53 377 101957 118183 42400818
Ventricular dysfunction 13.54 10.53 32 102302 4471 42514530
Pseudomonas infection 13.53 10.53 11 102323 15912 42503089
Blood urea increased 13.44 10.53 129 102205 32664 42486337
Aspergillus infection 13.39 10.53 11 102323 15826 42503175
Infection 13.34 10.53 189 102145 111879 42407122
Sleep apnoea syndrome 13.17 10.53 93 102241 21515 42497486
Neuralgia 13.17 10.53 26 102308 25621 42493380
Hypertransaminasaemia 13.16 10.53 3 102331 9224 42509777
Full blood count abnormal 13.12 10.53 33 102301 29843 42489158
Duodenitis 13.08 10.53 36 102298 5520 42513481
Peripheral vascular disorder 13.07 10.53 35 102299 5282 42513719
Pseudodementia 13.03 10.53 3 102331 3 42518998
Retinal disorder 12.89 10.53 15 102319 1160 42517841
Hepatic function abnormal 12.79 10.53 72 102262 51495 42467506
Pericardial haemorrhage 12.56 10.53 27 102307 3542 42515459
Nitritoid reaction 12.55 10.53 4 102330 23 42518978
Bronchopulmonary aspergillosis 12.49 10.53 17 102317 19412 42499589
Clostridium difficile infection 12.49 10.53 22 102312 22637 42496364
Product substitution issue 12.48 10.53 57 102277 11233 42507768
Hyperlactacidaemia 12.41 10.53 31 102303 4485 42514516
Bronchiectasis 12.38 10.53 15 102319 18004 42500997
Gastritis 12.30 10.53 99 102235 23848 42495153
No adverse event 12.30 10.53 50 102284 38971 42480030
Productive cough 12.26 10.53 73 102261 51494 42467507
Coronary artery restenosis 12.23 10.53 13 102321 909 42518092
Ventricular extrasystoles 12.22 10.53 64 102270 13326 42505675
Artery dissection 12.13 10.53 8 102326 286 42518715
Drug dependence 12.11 10.53 33 102301 29061 42489940
Food aversion 12.04 10.53 10 102324 511 42518490
Akathisia 12.03 10.53 5 102329 10446 42508555
Nodal rhythm 11.99 10.53 17 102317 1600 42517401
Retinal thickening 11.94 10.53 9 102325 399 42518602
Abscess 11.91 10.53 10 102324 14238 42504763
Dupuytren's contracture 11.82 10.53 3 102331 6 42518995
Impaired quality of life 11.79 10.53 10 102324 14167 42504834
Syringe issue 11.77 10.53 3 102331 8553 42510448
Immune effector cell-associated neurotoxicity syndrome 11.77 10.53 4 102330 9457 42509544
Renal tubular disorder 11.75 10.53 32 102302 4877 42514124
Synovitis 11.75 10.53 12 102322 15555 42503446
Device leakage 11.71 10.53 5 102329 10280 42508721
Pneumocystis jirovecii pneumonia 11.70 10.53 27 102307 25154 42493847
Pulmonary alveolar haemorrhage 11.67 10.53 11 102323 14805 42504196
Spermatozoa progressive motility abnormal 11.65 10.53 4 102330 30 42518971
Carotid artery stenosis 11.61 10.53 34 102300 5402 42513599
Altered state of consciousness 11.58 10.53 34 102300 29225 42489776
Cytopenia 11.57 10.53 15 102319 17482 42501519
Non-small cell lung cancer stage IIIB 11.54 10.53 4 102330 31 42518970
Haematotoxicity 11.49 10.53 6 102328 10979 42508022
Cardiac disorder 11.45 10.53 173 102161 48759 42470242
Premature baby 11.44 10.53 24 102310 23129 42495872
Crystal urine 11.37 10.53 5 102329 77 42518924
Pulmonary valve incompetence 11.36 10.53 14 102320 1149 42517852
Metabolic encephalopathy 11.31 10.53 33 102301 5232 42513769
Temporal lobe epilepsy 11.25 10.53 7 102327 226 42518775
Gravitational oedema 11.24 10.53 11 102323 697 42518304
Therapeutic product effect decreased 11.22 10.53 52 102282 39098 42479903
Labile hypertension 11.14 10.53 5 102329 81 42518920
International normalised ratio decreased 11.14 10.53 30 102304 4542 42514459
Therapy interrupted 11.04 10.53 23 102311 22227 42496774
Coronary artery reocclusion 11.03 10.53 5 102329 83 42518918
Haemodilution 11.01 10.53 4 102330 36 42518965
Drug hypersensitivity 11.00 10.53 170 102164 99219 42419782
Sinus arrhythmia 10.99 10.53 12 102322 865 42518136
Vocal cord polypectomy 10.97 10.53 3 102331 9 42518992
Pancreatitis 10.92 10.53 155 102179 43113 42475888
Myocarditis 10.79 10.53 18 102316 18920 42500081
Joint range of motion decreased 10.79 10.53 42 102292 7711 42511290
Brain oedema 10.79 10.53 14 102320 16313 42502688
Anticoagulation drug level above therapeutic 10.78 10.53 21 102313 2569 42516432
Dilatation atrial 10.76 10.53 19 102315 2156 42516845
Therapeutic response shortened 10.75 10.53 10 102324 13544 42505457
Itching scar 10.73 10.53 4 102330 39 42518962
Cardiomegaly 10.71 10.53 73 102261 16693 42502308
Epilepsy 10.66 10.53 30 102304 26141 42492860
Hydrocele male infected 10.64 10.53 4 102330 40 42518961
Pituitary tumour recurrent 10.62 10.53 5 102329 91 42518910
Poisoning 10.61 10.53 66 102268 14633 42504368
Laryngeal pain 10.60 10.53 21 102313 2601 42516400
Arteriosclerosis coronary artery 10.58 10.53 79 102255 18598 42500403
Liver disorder 10.58 10.53 54 102280 39590 42479411
Gastritis erosive 10.54 10.53 37 102297 6466 42512535

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 1351.33 9.88 1610 219656 153907 110214126
Myocardial infarction 600.86 9.88 1242 220024 190841 110177192
Off label use 582.34 9.88 1346 219920 1498839 108869194
Completed suicide 514.69 9.88 1346 219920 241035 110126998
Hypotension 486.85 9.88 2206 219060 521643 109846390
Cardiac failure congestive 446.03 9.88 954 220312 150046 110217987
Coronary artery disease 398.24 9.88 597 220669 71093 110296940
Pemphigus 393.90 9.88 7 221259 214563 110153470
Sinus bradycardia 377.80 9.88 375 220891 29108 110338925
Systemic lupus erythematosus 367.64 9.88 40 221226 254298 110113735
Hand deformity 365.38 9.88 17 221249 218489 110149544
Pericarditis 336.53 9.88 27 221239 219087 110148946
Maternal exposure during pregnancy 328.53 9.88 57 221209 254826 110113207
Syncope 308.42 9.88 999 220267 201537 110166496
Cerebrovascular accident 306.28 9.88 927 220339 180357 110187676
Duodenal ulcer perforation 303.14 9.88 12 221254 177688 110190345
Folliculitis 287.08 9.88 11 221255 167642 110200391
Glossodynia 276.74 9.88 54 221212 221950 110146083
Acute kidney injury 259.07 9.88 2162 219104 633268 109734765
Wound 253.27 9.88 77 221189 234360 110133673
Product use in unapproved indication 249.81 9.88 317 220949 447060 109920973
Muscle injury 245.40 9.88 8 221258 140799 110227234
Intentional product use issue 214.71 9.88 114 221152 247792 110120241
Drug interaction 204.78 9.88 1704 219562 498479 109869554
Sleep disorder due to general medical condition, insomnia type 174.06 9.88 9 221257 105634 110262399
Atrial fibrillation 171.80 9.88 910 220356 228732 110139301
Discomfort 169.96 9.88 110 221156 214597 110153436
Irritable bowel syndrome 168.41 9.88 59 221207 164156 110203877
Fibromyalgia 167.55 9.88 66 221200 170843 110197190
Acute myocardial infarction 167.17 9.88 455 220811 83322 110284711
Hyperkalaemia 164.32 9.88 621 220645 135175 110232858
General physical health deterioration 164.28 9.88 381 220885 424914 109943119
Facet joint syndrome 163.57 9.88 7 221259 96821 110271212
Nasopharyngitis 159.91 9.88 344 220922 394017 109974016
Angina unstable 158.96 9.88 180 221086 16252 110351781
Lip dry 154.55 9.88 12 221254 100071 110267962
Stomatitis 154.37 9.88 188 221078 270054 110097979
Hyponatraemia 154.34 9.88 850 220416 216803 110151230
Rhabdomyolysis 152.68 9.88 559 220707 119842 110248191
Renal failure 148.25 9.88 866 220400 225708 110142325
Drug ineffective 144.96 9.88 2158 219108 1518382 108849651
Asthma 143.08 9.88 174 221092 250117 110117916
Infection 142.67 9.88 321 220945 361879 110006154
Hypertensive crisis 142.54 9.88 208 221058 24164 110343869
Helicobacter infection 141.48 9.88 95 221171 181782 110186251
Pyrexia 141.11 9.88 1136 220130 897129 109470904
Electric shock 134.41 9.88 68 221198 1760 110366273
Ill-defined disorder 133.05 9.88 74 221192 156779 110211254
Febrile neutropenia 131.15 9.88 273 220993 316494 110051539
Wheezing 131.08 9.88 192 221074 255038 110112995
Blister 127.93 9.88 160 221106 227216 110140817
Exposure during pregnancy 126.83 9.88 90 221176 167334 110200699
Psoriatic arthropathy 126.59 9.88 124 221142 196637 110171396
Fall 126.55 9.88 1799 219467 601683 109766350
Shock 126.44 9.88 310 220956 53278 110314755
Therapeutic product effect incomplete 125.39 9.88 158 221108 223647 110144386
Live birth 124.56 9.88 3 221263 69481 110298552
Myelosuppression 123.93 9.88 20 221246 94320 110273713
Dehydration 122.16 9.88 967 220299 278544 110089489
Angina pectoris 121.95 9.88 336 220930 61959 110306074
International normalised ratio increased 121.27 9.88 416 220850 86356 110281677
Drug intolerance 120.14 9.88 414 220852 406098 109961935
Infusion related reaction 118.95 9.88 379 220887 380783 109987250
Swelling 116.72 9.88 339 220927 350702 110017331
Treatment failure 115.53 9.88 238 221028 276996 110091037
Peripheral venous disease 114.70 9.88 16 221250 84101 110283932
Dizziness 110.13 9.88 1985 219281 696208 109671825
Heart rate decreased 109.81 9.88 390 220876 82366 110285667
Wound infection 109.10 9.88 29 221237 96436 110271597
Grip strength decreased 107.58 9.88 16 221250 80158 110287875
Liver injury 107.33 9.88 86 221180 150327 110217706
Coronary arterial stent insertion 106.47 9.88 91 221175 5824 110362209
Deep vein thrombosis postoperative 104.63 9.88 3 221263 59288 110308745
Lower respiratory tract infection 103.59 9.88 206 221060 242900 110125133
Transient ischaemic attack 102.19 9.88 321 220945 63661 110304372
Atrioventricular block first degree 100.55 9.88 133 221133 14092 110353941
Sinusitis 100.45 9.88 284 220982 296404 110071629
Myalgia 98.04 9.88 771 220495 221610 110146423
Hypersensitivity 96.81 9.88 447 220819 403551 109964482
Bursitis 95.59 9.88 72 221194 129846 110238187
Condition aggravated 95.33 9.88 975 220291 733861 109634172
Synovitis 95.29 9.88 259 221007 273833 110094200
Blood creatinine increased 93.05 9.88 656 220610 182233 110185800
Type 2 diabetes mellitus 92.27 9.88 132 221134 177100 110190933
Lactic acidosis 91.21 9.88 398 220868 92413 110275620
Impaired healing 90.60 9.88 159 221107 196558 110171475
Coordination abnormal 88.16 9.88 171 221095 25057 110342976
Haematocrit decreased 88.07 9.88 312 220954 65805 110302228
Autoimmune disorder 88.01 9.88 13 221253 65470 110302563
Chest pain 86.93 9.88 1142 220124 375233 109992800
Neovascularisation 86.80 9.88 50 221216 1687 110366346
Night sweats 85.52 9.88 85 221181 133898 110234135
Loss of consciousness 84.55 9.88 677 220589 195629 110172404
Blood glucose increased 84.39 9.88 503 220763 131993 110236040
Alopecia 81.90 9.88 413 220853 364340 110003693
COVID-19 81.89 9.88 236 221030 244824 110123209
Coronary artery occlusion 81.41 9.88 127 221139 15645 110352388
Atrioventricular block complete 81.29 9.88 145 221121 19937 110348096
Lung disorder 80.69 9.88 148 221118 179899 110188134
Myocardial ischaemia 79.16 9.88 169 221097 26515 110341518
Loss of employment 78.32 9.88 60 221206 3284 110364749
Sleep disorder 78.19 9.88 176 221090 198468 110169565
Abdominal discomfort 75.36 9.88 470 220796 393388 109974645
Onychomadesis 74.87 9.88 4 221262 45659 110322374
Adjustment disorder with depressed mood 74.69 9.88 3 221263 43880 110324153
Obesity 74.56 9.88 70 221196 113281 110254752
Blood pressure increased 74.55 9.88 818 220448 257555 110110478
Metabolic acidosis 74.33 9.88 395 220871 99349 110268684
Mobility decreased 72.67 9.88 238 221028 237184 110130849
Intervertebral discitis 71.78 9.88 79 221187 6911 110361122
Orthostatic hypotension 71.23 9.88 292 220974 65957 110302076
Blood pressure inadequately controlled 71.10 9.88 82 221184 7551 110360482
Cardiac arrest 70.28 9.88 651 220615 196102 110171931
Taste disorder 69.63 9.88 22 221244 65365 110302668
Blood urea increased 68.66 9.88 254 221012 54703 110313330
Contraindicated product administered 68.54 9.88 260 221006 248007 110120026
Circulatory collapse 68.01 9.88 215 221051 42778 110325255
Lethargy 67.98 9.88 368 220898 93208 110274825
Prescribed overdose 67.75 9.88 46 221220 87535 110280498
Hepatic enzyme increased 67.18 9.88 372 220894 320520 110047513
Post-traumatic stress disorder 66.79 9.88 74 221192 6522 110361511
Drug abuse 66.76 9.88 161 221105 177250 110190783
Liver function test increased 66.52 9.88 48 221218 88500 110279533
C-reactive protein abnormal 66.12 9.88 98 221168 129597 110238436
Product complaint 65.94 9.88 108 221158 13864 110354169
Hypoglycaemia 65.32 9.88 427 220839 115677 110252356
Demyelination 64.86 9.88 87 221179 9342 110358691
Atrioventricular block 64.68 9.88 119 221147 16758 110351275
Nail disorder 64.41 9.88 18 221248 57917 110310116
Anuria 63.02 9.88 146 221120 24195 110343838
Blood creatine phosphokinase increased 62.60 9.88 301 220965 72776 110295257
Asthenia 62.10 9.88 1811 219455 687188 109680845
Therapeutic product effect decreased 61.69 9.88 265 221001 244051 110123982
Palpitations 61.57 9.88 536 220730 158676 110209357
Overdose 61.49 9.88 727 220539 233067 110134966
Ventricular hypertrophy 61.16 9.88 73 221193 6972 110361061
Hypokalaemia 60.36 9.88 594 220672 181854 110186179
Hypomagnesaemia 60.16 9.88 260 221006 60110 110307923
Rheumatoid factor positive 60.06 9.88 107 221159 131533 110236500
IgM nephropathy 59.99 9.88 19 221247 132 110367901
Cytokine release syndrome 59.85 9.88 33 221233 70273 110297760
Coronary artery bypass 59.83 9.88 67 221199 5975 110362058
Pulmonary oedema 58.96 9.88 374 220892 100285 110267748
Emotional distress 58.33 9.88 210 221056 44637 110323396
Melaena 58.03 9.88 282 220984 68475 110299558
Epilepsy 57.93 9.88 69 221197 100140 110267893
Neutropenia 57.13 9.88 477 220789 374143 109993890
Exposure via ingestion 56.70 9.88 59 221207 4841 110363192
Drug resistance 56.51 9.88 21 221245 56353 110311680
Joint range of motion decreased 55.60 9.88 99 221167 121733 110246300
Poisoning 55.00 9.88 155 221111 28950 110339083
Blood glucose decreased 54.70 9.88 156 221110 29332 110338701
Haemodialysis 54.62 9.88 114 221152 17605 110350428
Sinus arrest 54.41 9.88 54 221212 4188 110363845
Hypercholesterolaemia 54.18 9.88 61 221205 90776 110277257
Sinus node dysfunction 54.05 9.88 78 221188 8969 110359064
Sleep disorder due to a general medical condition 52.93 9.88 19 221247 52093 110315940
Blood pressure systolic increased 52.15 9.88 314 220952 82677 110285356
Post cholecystectomy syndrome 52.07 9.88 28 221238 824 110367209
Coronary artery stenosis 51.46 9.88 96 221170 13662 110354371
Gastrointestinal disorder 51.44 9.88 279 220987 241673 110126360
Frequent bowel movements 50.69 9.88 41 221225 71349 110296684
Bone erosion 50.46 9.88 15 221251 46356 110321677
Red blood cell count decreased 50.44 9.88 263 221003 65660 110302373
Incorrect route of product administration 50.42 9.88 33 221233 64028 110304005
Lower limb fracture 50.18 9.88 46 221220 75302 110292731
Hyperhidrosis 49.94 9.88 584 220682 186714 110181319
Weight increased 49.80 9.88 568 220698 419076 109948957
Ulcer 48.71 9.88 193 221073 42923 110325110
C-reactive protein 48.67 9.88 3 221263 30328 110337705
Inflammation 48.52 9.88 210 221056 193028 110175005
Pregnancy 47.96 9.88 21 221245 51046 110316987
Haemoglobin decreased 47.86 9.88 731 220535 247996 110120037
Presyncope 47.53 9.88 209 221057 48678 110319355
Colitis ulcerative 47.19 9.88 51 221215 77312 110290721
Hepatic steatosis 46.90 9.88 208 221058 48623 110319410
Temperature intolerance 46.85 9.88 93 221173 13857 110354176
Cardiomegaly 46.37 9.88 146 221120 28984 110339049
Fear 46.28 9.88 126 221140 23067 110344966
Diverticulum 45.67 9.88 98 221168 15428 110352605
Product use issue 45.67 9.88 401 220865 311294 110056739
Joint swelling 45.55 9.88 618 220648 442227 109925806
Cardiogenic shock 45.43 9.88 231 221035 57107 110310926
Coeliac disease 45.15 9.88 15 221251 43172 110324861
Granuloma skin 45.07 9.88 81 221185 11202 110356831
Arthropathy 44.77 9.88 364 220902 287158 110080875
Hyperlipidaemia 44.21 9.88 165 221101 35683 110332350
Hospitalisation 44.17 9.88 142 221124 142351 110225682
Product substitution issue 43.76 9.88 123 221143 22938 110345095
Blood potassium increased 43.50 9.88 156 221110 33093 110334940
Cardiac disorder 43.18 9.88 281 220985 75999 110292034
Hyperglycaemia 41.96 9.88 303 220963 84787 110283246
Cytomegalovirus infection 41.57 9.88 29 221237 54415 110313618
Anhedonia 41.55 9.88 94 221172 15334 110352699
Rectal polyp 41.36 9.88 30 221236 1510 110366523
Onychomycosis 40.96 9.88 13 221253 38518 110329515
Frustration tolerance decreased 40.54 9.88 67 221199 8664 110359369
Carbuncle 40.36 9.88 29 221237 1438 110366595
Vulvovaginal burning sensation 39.65 9.88 33 221233 2036 110365997
Device expulsion 39.57 9.88 7 221259 30884 110337149
Laryngitis 38.96 9.88 18 221248 42393 110325640
Acute coronary syndrome 38.80 9.88 118 221148 22994 110345039
Renal injury 38.68 9.88 103 221163 18610 110349423
Blood immunoglobulin A increased 38.63 9.88 29 221237 1539 110366494
Cerebral haematoma 38.29 9.88 69 221197 9563 110358470
Blood pressure decreased 38.19 9.88 375 220891 114716 110253317
Blood parathyroid hormone decreased 37.79 9.88 82 221184 13007 110355026
Glomerular filtration rate increased 37.22 9.88 31 221235 1914 110366119
Blood pressure immeasurable 37.08 9.88 34 221232 2389 110365644
Multiple fractures 36.76 9.88 65 221201 8875 110359158
Intentional product misuse 36.14 9.88 140 221126 132764 110235269
Hypertension 35.11 9.88 1299 219967 508785 109859248
Neutrophil count decreased 35.11 9.88 124 221142 120817 110247216
Hip arthroplasty 34.93 9.88 36 221230 55777 110312256
Feeling abnormal 34.70 9.88 531 220735 180180 110187853
Aspergillus infection 34.62 9.88 5 221261 25611 110342422
Ear infection 34.37 9.88 45 221221 62687 110305346
Fear of eating 34.10 9.88 18 221248 510 110367523
Diabetes mellitus 34.05 9.88 326 220940 99055 110268978
Mucosal inflammation 34.02 9.88 90 221176 96051 110271982
Inappropriate schedule of product administration 33.94 9.88 253 221013 203384 110164649
Hypovolaemia 33.92 9.88 108 221158 21566 110346467
Vitamin B12 increased 33.74 9.88 30 221236 2025 110366008
Potentiating drug interaction 33.68 9.88 73 221193 11570 110356463
Dilatation atrial 33.58 9.88 40 221226 3812 110364221
Mitral valve incompetence 33.56 9.88 144 221122 33185 110334848
Panniculitis 33.47 9.88 87 221179 15495 110352538
Aspartate aminotransferase 33.38 9.88 22 221244 947 110367086
Vasculitic rash 33.24 9.88 31 221235 2226 110365807
Epistaxis 33.20 9.88 403 220863 129969 110238064
Knee arthroplasty 33.17 9.88 49 221217 64899 110303134
Atrioventricular block second degree 33.02 9.88 59 221207 8122 110359911
BRASH syndrome 33.02 9.88 39 221227 3684 110364349
Diabetic neuropathy 32.89 9.88 54 221212 6945 110361088
Oedema peripheral 32.64 9.88 875 220391 327785 110040248
Road traffic accident 32.61 9.88 108 221158 107290 110260743
Body height decreased 32.61 9.88 68 221198 10495 110357538
Rheumatoid factor increased 32.34 9.88 32 221234 2473 110365560
COVID-19 pneumonia 32.25 9.88 17 221249 37126 110330907
Peripheral coldness 31.44 9.88 95 221171 18445 110349588
Erectile dysfunction 31.39 9.88 95 221171 18461 110349572
Malignant spinal cord compression 31.38 9.88 12 221254 154 110367879
Bronchiectasis 31.25 9.88 17 221249 36476 110331557
Gastric ulcer 31.23 9.88 160 221106 39667 110328366
Cardio-respiratory arrest 31.23 9.88 362 220904 115474 110252559
Hypophagia 31.10 9.88 196 221070 52430 110315603
Femur fracture 31.03 9.88 173 221093 44296 110323737
Neoplasm skin 30.82 9.88 35 221231 3169 110364864
Skin necrosis 30.80 9.88 104 221162 21408 110346625
Granulocyte count increased 30.68 9.88 28 221238 1955 110366078
Nodal rhythm 30.59 9.88 36 221230 3387 110364646
Change of bowel habit 30.46 9.88 33 221233 2836 110365197
Carotid artery stenosis 30.21 9.88 61 221205 9202 110358831
Migraine 30.18 9.88 210 221056 171442 110196591
Confusional state 29.97 9.88 1184 220082 467496 109900537
Haemorrhoids 29.88 9.88 146 221120 35526 110332507
Angioedema 29.84 9.88 315 220951 98185 110269848
Vulvovaginal pruritus 29.72 9.88 35 221231 3296 110364737
Gait inability 29.67 9.88 156 221110 136220 110231813
Haemophagocytic lymphohistiocytosis 29.60 9.88 13 221253 31546 110336487
Basal cell carcinoma 29.54 9.88 173 221093 45097 110322936
Overweight 29.21 9.88 49 221217 6415 110361618
Muscle spasticity 28.95 9.88 18 221248 35897 110332136
Urticaria 28.92 9.88 456 220810 318401 110049632
Lacunar infarction 28.87 9.88 48 221218 6238 110361795
Pacemaker generated rhythm 28.12 9.88 9 221257 65 110367968
Drug hypersensitivity 27.98 9.88 693 220573 453397 109914636
Vitamin B12 deficiency 27.90 9.88 62 221204 9993 110358040
Arrhythmia 27.81 9.88 236 221030 69339 110298694
International normalised ratio decreased 27.77 9.88 55 221211 8181 110359852
Duodenal ulcer 27.64 9.88 94 221172 19420 110348613
Balance disorder 27.41 9.88 355 220911 116205 110251828
Multiple sclerosis 27.41 9.88 113 221153 25585 110342448
Graft versus host disease 27.04 9.88 3 221263 18803 110349230
Product dose omission issue 26.94 9.88 467 220799 321315 110046718
Premature delivery 26.62 9.88 14 221252 30618 110337415
Monoclonal immunoglobulin present 26.59 9.88 29 221237 2511 110365522
Pneumonia 26.55 9.88 1459 219807 875255 109492778
Pancreatitis acute 26.54 9.88 209 221057 60065 110307968
Disease progression 26.36 9.88 337 220929 243697 110124336
Laryngospasm 26.08 9.88 39 221227 4629 110363404
Liver function test abnormal 26.05 9.88 231 221035 68719 110299314
Depressed level of consciousness 26.00 9.88 341 220925 111937 110256096
Bradyarrhythmia 25.84 9.88 40 221226 4894 110363139
Electrocardiogram J wave 25.73 9.88 9 221257 88 110367945
Pericardial haemorrhage 25.53 9.88 41 221225 5176 110362857
Therapy partial responder 25.43 9.88 22 221244 37039 110330994
Vaginal discharge 25.39 9.88 3 221263 17905 110350128
Vascular graft 25.33 9.88 26 221240 2099 110365934
Tongue oedema 25.31 9.88 53 221213 8203 110359830
Cerebral haemorrhage 25.24 9.88 219 221047 64749 110303284
Intracranial haematoma 25.20 9.88 19 221247 1015 110367018
Urinary tract infection 25.17 9.88 842 220424 325440 110042593
Vision blurred 25.11 9.88 380 220886 128642 110239391
Drug ineffective for unapproved indication 25.06 9.88 113 221153 102725 110265308
Renal artery stenosis 25.05 9.88 34 221232 3692 110364341
Swelling face 24.65 9.88 288 220978 92033 110276000
Malignant neoplasm progression 24.49 9.88 227 221039 174340 110193693
Musculoskeletal stiffness 24.43 9.88 403 220863 279419 110088614
Blood cholesterol increased 24.35 9.88 244 221022 184541 110183492
Plasmapheresis 24.32 9.88 17 221249 807 110367226
Cardiac valve disease 24.26 9.88 45 221221 6376 110361657
Arteriosclerosis 24.16 9.88 106 221160 24661 110343372
Injection site reaction 24.10 9.88 94 221172 88976 110279057
Abnormal dreams 24.08 9.88 68 221198 12712 110355321
Entropion 24.08 9.88 9 221257 108 110367925
Ischaemic cardiomyopathy 24.06 9.88 51 221215 7960 110360073
Gastrointestinal haemorrhage 24.04 9.88 465 220801 165053 110202980
Laryngeal pain 24 9.88 43 221223 5932 110362101
Therapy non-responder 23.63 9.88 201 221065 157106 110210927
Sciatica 23.44 9.88 100 221166 92299 110275734
Respiratory arrest 23.43 9.88 198 221068 58101 110309932
Arteriosclerosis coronary artery 23.37 9.88 106 221160 25012 110343021
Unresponsive to stimuli 23.23 9.88 212 221054 63578 110304455
Hypocalcaemia 23.18 9.88 216 221050 65150 110302883
Blood triglycerides increased 23.04 9.88 102 221164 23824 110344209
Cytomegalovirus viraemia 22.81 9.88 4 221262 17760 110350273
Device dislocation 22.77 9.88 18 221248 31686 110336347
Renal cyst 22.70 9.88 84 221182 18088 110349945
Gingival hypertrophy 22.53 9.88 35 221231 4296 110363737
Walking aid user 22.48 9.88 11 221255 25064 110342969
Memory impairment 22.39 9.88 269 220997 196675 110171358
Azotaemia 22.37 9.88 57 221209 10028 110358005
Hypothalamo-pituitary disorder 22.29 9.88 28 221238 2818 110365215
Adverse drug reaction 22.27 9.88 122 221144 105437 110262596
Pulse absent 22.18 9.88 61 221205 11231 110356802
Death 22.07 9.88 1158 220108 697711 109670322
Blood pressure diastolic decreased 22.05 9.88 135 221131 35750 110332283
Toxicity to various agents 22.03 9.88 1174 220092 479381 109888652
Vertigo 21.88 9.88 268 220998 86602 110281431
Dyslipidaemia 21.82 9.88 76 221190 15889 110352144
Cytopenia 21.75 9.88 17 221249 30099 110337934
Peripheral vascular disorder 21.72 9.88 51 221215 8525 110359508
Hiatus hernia 21.71 9.88 111 221155 27495 110340538
Urinary incontinence 21.68 9.88 169 221097 48418 110319615
Rash 21.67 9.88 1384 219882 819580 109548453
Phaeochromocytoma 21.65 9.88 16 221250 829 110367204
Jaundice 21.64 9.88 197 221069 59039 110308994
Drop attacks 21.63 9.88 18 221248 1110 110366923
Dyskinesia oesophageal 21.58 9.88 7 221259 53 110367980
Paroxysmal atrioventricular block 21.49 9.88 6 221260 25 110368008
High density lipoprotein decreased 21.44 9.88 40 221226 5693 110362340
Sinus arrhythmia 21.38 9.88 24 221242 2146 110365887
Drug use disorder 21.27 9.88 5 221261 18069 110349964
Nodal arrhythmia 21.25 9.88 24 221242 2160 110365873
Hypertransaminasaemia 21.21 9.88 11 221255 24244 110343789
Retinal vein thrombosis 21.11 9.88 15 221251 731 110367302
Guillain-Barre syndrome 21.07 9.88 58 221208 10686 110357347
Upper respiratory tract infection 21.01 9.88 165 221101 131163 110236870
Haemorrhagic stroke 20.94 9.88 68 221198 13721 110354312
Haematotoxicity 20.88 9.88 8 221258 21074 110346959
Bundle branch block right 20.86 9.88 63 221203 12228 110355805
Rhinalgia 20.78 9.88 32 221234 3897 110364136
Glycosylated haemoglobin increased 20.74 9.88 98 221168 23521 110344512
Skin neoplasm excision 20.68 9.88 23 221243 2035 110365998
Female genital tract fistula 20.61 9.88 4 221262 16515 110351518
Purpura 20.56 9.88 100 221166 24288 110343745
Pain 20.47 9.88 1639 219627 953316 109414717
Supraventricular extrasystoles 20.43 9.88 48 221218 8025 110360008
Pruritus 20.42 9.88 953 220313 580607 109787426
Blood sodium decreased 20.38 9.88 139 221127 38180 110329853
Blood alkaline phosphatase increased 20.16 9.88 224 221042 70711 110297322
Bronchopulmonary aspergillosis 20.16 9.88 18 221248 29845 110338188
Iron deficiency 20.06 9.88 6 221260 18470 110349563
Fibrosis 19.96 9.88 46 221220 7596 110360437
Wrong drug 19.95 9.88 12 221254 439 110367594
Dialysis 19.93 9.88 85 221181 19534 110348499
Ventricular extrasystoles 19.92 9.88 94 221172 22547 110345486
Alanine aminotransferase increased 19.90 9.88 495 220771 183278 110184755
Breath sounds abnormal 19.88 9.88 102 221164 25302 110342731
Gastritis 19.82 9.88 179 221087 53520 110314513
Dysphagia 19.81 9.88 424 220842 153176 110214857
Haematemesis 19.80 9.88 193 221073 58915 110309118
Adverse reaction 19.78 9.88 18 221248 29576 110338457
Urine odour abnormal 19.77 9.88 45 221221 7370 110360663
Blood urine 19.74 9.88 16 221250 951 110367082
Infective pulmonary exacerbation of cystic fibrosis 19.69 9.88 3 221263 14768 110353265
Optic ischaemic neuropathy 19.49 9.88 32 221234 4115 110363918
Confusion postoperative 19.48 9.88 11 221255 357 110367676
Hypothermia 19.48 9.88 104 221162 26198 110341835
Osteoarthritis 19.42 9.88 253 221013 182370 110185663
Joint noise 19.38 9.88 36 221230 5107 110362926
Deafness 19.36 9.88 105 221161 26604 110341429
Proctitis 19.30 9.88 5 221261 16922 110351111
Blood pressure systolic decreased 19.26 9.88 65 221201 13376 110354657
Paradoxical drug reaction 19.25 9.88 53 221213 9764 110358269
Depressed mood 19.14 9.88 196 221070 60613 110307420
Visual acuity reduced 19.12 9.88 120 221146 32053 110335980
Renal impairment 19.06 9.88 503 220763 187942 110180091
Chronic kidney disease 19.06 9.88 235 221031 76056 110291977
Post transplant lymphoproliferative disorder 19.02 9.88 4 221262 15609 110352424
Purple glove syndrome 18.83 9.88 10 221256 287 110367746
Skull fracture 18.80 9.88 22 221244 2058 110365975
Encapsulating peritoneal sclerosis 18.78 9.88 15 221251 873 110367160
Coronary artery restenosis 18.77 9.88 17 221249 1175 110366858
Pathogen resistance 18.72 9.88 6 221260 17666 110350367
Progressive multifocal leukoencephalopathy 18.70 9.88 99 221167 24857 110343176
Hypoaesthesia 18.68 9.88 482 220784 313741 110054292
Coma scale abnormal 18.57 9.88 52 221214 9674 110358359
Thyroid atrophy 18.51 9.88 10 221256 297 110367736
Dyspnoea 18.45 9.88 2505 218761 1104367 109263666
Rheumatoid nodule 18.40 9.88 85 221181 20211 110347822
Continuous haemodiafiltration 18.38 9.88 21 221245 1914 110366119
Laryngotracheal oedema 18.32 9.88 6 221260 47 110367986
Bundle branch block left 18.18 9.88 62 221204 12826 110355207
Coma scale normal 18.10 9.88 4 221262 4 110368029
Subdural haematoma 18.08 9.88 130 221136 36324 110331709
Hip fracture 17.81 9.88 126 221140 35025 110333008
Leukopenia 17.77 9.88 201 221065 148590 110219443
Cold sweat 17.62 9.88 89 221177 21942 110346091
Pneumocystis jirovecii pneumonia 17.52 9.88 37 221229 42698 110325335
Postoperative wound infection 17.38 9.88 70 221196 15683 110352350
Ventricular dysfunction 17.24 9.88 43 221223 7468 110360565
Bone disorder 17.22 9.88 86 221180 21106 110346927
Furuncle 17.20 9.88 47 221219 8621 110359412
Rectosigmoid cancer 17.13 9.88 10 221256 346 110367687
Mental status changes 17.12 9.88 230 221036 75892 110292141
Ankylosing spondylitis 17.08 9.88 5 221261 15607 110352426
Infusion site reaction 17.04 9.88 7 221259 17675 110350358
Ischaemic stroke 17.04 9.88 141 221125 41122 110326911
Cholelithiasis 17.00 9.88 198 221068 63224 110304809
Paraplegia 16.95 9.88 38 221228 6162 110361871
Illness anxiety disorder 16.86 9.88 9 221257 261 110367772
Unevaluable event 16.82 9.88 187 221079 59040 110308993
Liver disorder 16.66 9.88 193 221073 142050 110225983
Infusion site pain 16.62 9.88 7 221259 17412 110350621
Nephropathy 16.62 9.88 62 221204 13405 110354628
Nephrogenic systemic fibrosis 16.58 9.88 35 221231 5448 110362585
Coronary artery thrombosis 16.57 9.88 26 221240 3218 110364815
Low density lipoprotein increased 16.56 9.88 53 221213 10613 110357420
Oral candidiasis 16.53 9.88 41 221225 44719 110323314
Ear pain 16.52 9.88 53 221213 53173 110314860
Disorientation 16.51 9.88 215 221051 70456 110297577
Hypercalcaemia 16.45 9.88 154 221112 46503 110321530
Duodenitis 16.43 9.88 48 221218 9148 110358885
Female orgasmic disorder 16.41 9.88 5 221261 30 110368003
Inappropriate antidiuretic hormone secretion 16.37 9.88 120 221146 33731 110334302
Neurotoxicity 16.11 9.88 38 221228 42169 110325864
Phaeochromocytoma crisis 16.10 9.88 11 221255 503 110367530
Mental status changes postoperative 16.03 9.88 8 221258 201 110367832
Impaired quality of life 15.97 9.88 22 221244 29995 110338038
Chromaturia 15.91 9.88 107 221159 29253 110338780
Polyp 15.87 9.88 50 221216 9930 110358103
Sinoatrial block 15.81 9.88 17 221249 1448 110366585
Retinal thickening 15.69 9.88 9 221257 301 110367732
Hallucination, visual 15.64 9.88 134 221132 39471 110328562
Respiratory tract infection 15.53 9.88 82 221184 71535 110296498
Wrist deformity 15.52 9.88 25 221241 3164 110364869
Tricuspid valve incompetence 15.43 9.88 91 221175 23782 110344251
Peripheral swelling 15.41 9.88 656 220610 403378 109964655
Barrett's oesophagus 15.36 9.88 12 221254 676 110367357
Breast calcifications 15.36 9.88 14 221252 976 110367057
Medical diet 15.34 9.88 4 221262 12 110368021
Vertigo positional 15.33 9.88 28 221238 3920 110364113
Hepatic function abnormal 15.32 9.88 110 221156 89185 110278848
Spinal disorder 15.32 9.88 55 221211 11673 110356360
Therapy interrupted 15.19 9.88 50 221216 49772 110318261
Peak expiratory flow rate decreased 15.18 9.88 12 221254 688 110367345
Throat irritation 15.17 9.88 169 221097 53383 110314650
Depression 15.08 9.88 778 220488 316557 110051476
Post procedural complication 14.96 9.88 98 221168 26560 110341473
Hypogammaglobulinaemia 14.92 9.88 11 221255 20065 110347968
Blood catecholamines decreased 14.88 9.88 4 221262 14 110368019
Coronary artery surgery 14.87 9.88 7 221259 154 110367879
Back injury 14.85 9.88 47 221219 47352 110320681
Stoma site haemorrhage 14.80 9.88 21 221245 2377 110365656
Gallbladder disorder 14.80 9.88 82 221184 20947 110347086
Nervousness 14.72 9.88 125 221141 36726 110331307
Prothrombin time prolonged 14.71 9.88 71 221195 17190 110350843
Burning sensation 14.70 9.88 207 221059 69005 110299028
BK virus infection 14.70 9.88 4 221262 13102 110354931
Somnolence 14.70 9.88 732 220534 296717 110071316
Throat clearing 14.69 9.88 29 221237 4304 110363729
Productive cough 14.62 9.88 152 221114 114153 110253880
Refusal of treatment by patient 14.58 9.88 47 221219 9447 110358586
Faeces discoloured 14.55 9.88 117 221149 33831 110334202
Petechiae 14.50 9.88 88 221178 23229 110344804
Lymphocyte count decreased 14.49 9.88 62 221204 57181 110310852
Electrocardiogram QRS complex prolonged 14.47 9.88 58 221208 12963 110355070
Drug dispensed to wrong patient 14.46 9.88 12 221254 737 110367296
Extrasystoles 14.46 9.88 43 221223 8275 110359758
Hepatitis acute 14.44 9.88 75 221191 18691 110349342
Dactylitis 14.42 9.88 28 221238 4105 110363928
Cerebral ischaemia 14.33 9.88 55 221211 12049 110355984
Purpura senile 14.33 9.88 11 221255 604 110367429
Red blood cell sedimentation rate abnormal 14.31 9.88 91 221175 24418 110343615
Skin ulcer 14.19 9.88 192 221074 63453 110304580
Neurofibrosarcoma 14.16 9.88 8 221258 260 110367773
Dementia Alzheimer's type 14.15 9.88 13 221253 916 110367117
Cyanosis 14.14 9.88 105 221161 29636 110338397
Pernicious anaemia 14.12 9.88 12 221254 762 110367271
Appendicitis 14.03 9.88 22 221244 28442 110339591
Dry mouth 14.02 9.88 299 220967 199649 110168384
Toxic epidermal necrolysis 14.02 9.88 62 221204 56665 110311368
Immunodeficiency 14.01 9.88 36 221230 38802 110329231
Cerebrovascular disorder 14.01 9.88 26 221240 3685 110364348
Limb discomfort 13.98 9.88 134 221132 40720 110327313
Antiacetylcholine receptor antibody positive 13.83 9.88 8 221258 272 110367761
Adenocarcinoma of colon 13.83 9.88 35 221231 6133 110361900
Aspartate aminotransferase increased 13.70 9.88 418 220848 159518 110208515
Renal vascular thrombosis 13.60 9.88 6 221260 113 110367920
Halo vision 13.57 9.88 11 221255 654 110367379
Adrenal insufficiency 13.52 9.88 137 221129 42253 110325780
Food allergy 13.49 9.88 12 221254 19936 110348097
Renal tubular disorder 13.49 9.88 39 221227 7390 110360643
Rash pruritic 13.39 9.88 273 220993 97796 110270237
Anion gap abnormal 13.32 9.88 12 221254 824 110367209
Cardiac stress test abnormal 13.32 9.88 12 221254 824 110367209
Enterocolitis 13.30 9.88 11 221255 18938 110349095
Rheumatoid arthritis 13.27 9.88 478 220788 299135 110068898
Head injury 13.23 9.88 138 221128 42879 110325154
Cystitis haemorrhagic 13.19 9.88 4 221262 12205 110355828
Tarsal tunnel syndrome 13.19 9.88 10 221256 539 110367494
Heart rate abnormal 13.14 9.88 38 221228 7200 110360833
Vitreous detachment 13.12 9.88 21 221245 2644 110365389
Device difficult to use 13.10 9.88 11 221255 18794 110349239
Lupus-like syndrome 13.09 9.88 40 221226 40752 110327281
Hot flush 13.04 9.88 195 221071 65841 110302192
Thrombotic microangiopathy 13.01 9.88 24 221242 29125 110338908
Haemorrhagic vasculitis 12.96 9.88 6 221260 127 110367906
Gastric ulcer haemorrhage 12.90 9.88 47 221219 10047 110357986
Pharyngeal oedema 12.88 9.88 66 221200 16362 110351671
Cystocele 12.77 9.88 13 221253 1039 110366994
Iatrogenic injury 12.76 9.88 16 221250 1607 110366426
Hepatic cirrhosis 12.75 9.88 81 221185 67545 110300488
Skin laceration 12.71 9.88 113 221153 33640 110334393
Hyperlactacidaemia 12.70 9.88 41 221225 8245 110359788
No adverse event 12.65 9.88 91 221175 73748 110294285
Cutaneous lupus erythematosus 12.62 9.88 24 221242 3464 110364569
Intracardiac thrombus 12.62 9.88 27 221239 4241 110363792
Nitritoid reaction 12.60 9.88 4 221262 28 110368005
Rebound effect 12.53 9.88 7 221259 14799 110353234
Weight loss poor 12.49 9.88 15 221251 1442 110366591
Labile hypertension 12.41 9.88 10 221256 589 110367444
Spermatozoa progressive motility abnormal 12.37 9.88 4 221262 30 110368003
Coronary artery reocclusion 12.27 9.88 6 221260 144 110367889
Exaggerated startle response 12.25 9.88 4 221262 31 110368002
Vulvovaginal discomfort 12.23 9.88 18 221248 2106 110365927
Cardiac flutter 12.22 9.88 32 221234 5725 110362308
Gastritis erosive 12.20 9.88 52 221214 11948 110356085
Injury 12.16 9.88 266 221000 176999 110191034
Cough 12.13 9.88 1077 220189 460564 109907469
Influenza 12.11 9.88 252 221014 168849 110199184
Extrapyramidal disorder 12.11 9.88 99 221167 28768 110339265
Drug dose omission by device 12.08 9.88 7 221259 14509 110353524
Genitourinary symptom 12.08 9.88 8 221258 347 110367686
Respiratory syncytial virus infection 12.04 9.88 7 221259 14477 110353556
Pemphigoid 12.02 9.88 74 221192 19633 110348400
Refusal of treatment by relative 12.02 9.88 11 221255 771 110367262
Cardioactive drug level increased 11.99 9.88 25 221241 3857 110364176
Dysphonia 11.95 9.88 216 221050 75713 110292320
Cerebellar haematoma 11.92 9.88 10 221256 624 110367409
Diabetes mellitus inadequate control 11.90 9.88 101 221165 29674 110338359
Hallucination, auditory 11.88 9.88 92 221174 26305 110341728
Rash pustular 11.83 9.88 54 221212 12775 110355258
Tremor 11.78 9.88 506 220760 201726 110166307
Nasal discomfort 11.76 9.88 33 221233 6148 110361885
Product dose omission in error 11.75 9.88 18 221248 23494 110344539
Musculoskeletal discomfort 11.71 9.88 84 221182 23454 110344579
Lid lag 11.70 9.88 6 221260 160 110367873
Dysgeusia 11.69 9.88 201 221065 69784 110298249
Device leakage 11.66 9.88 9 221257 16039 110351994
Sputum discoloured 11.62 9.88 24 221242 27921 110340112
Sepsis 11.56 9.88 536 220730 326810 110041223
Ulcer haemorrhage 11.55 9.88 17 221249 22554 110345479
Acidosis 11.55 9.88 81 221185 22450 110345583
Vitamin D deficiency 11.53 9.88 70 221196 18482 110349551
Electrocardiogram T wave inversion 11.47 9.88 31 221235 5649 110362384
Torsade de pointes 11.44 9.88 81 221185 22519 110345514
Nail pigmentation 11.40 9.88 8 221258 382 110367651
Stridor 11.38 9.88 35 221231 6860 110361173
Ischaemia 11.36 9.88 42 221224 9041 110358992
Intestinal ischaemia 11.32 9.88 63 221203 16116 110351917
Vocal cord polypectomy 11.27 9.88 3 221263 10 110368023
Back pain 11.25 9.88 875 220391 370121 109997912
Adenovirus infection 11.18 9.88 4 221262 10990 110357043
Electrocardiogram PR prolongation 11.17 9.88 16 221250 1827 110366206
Dilatation ventricular 11.17 9.88 25 221241 4050 110363983
Cardiac output decreased 11.15 9.88 17 221249 2052 110365981
Dystrophic calcification 11.15 9.88 6 221260 177 110367856
Sopor 11.12 9.88 117 221149 36429 110331604
Bladder disorder 11.12 9.88 48 221218 11089 110356944
Immune effector cell-associated neurotoxicity syndrome 11.12 9.88 8 221258 14774 110353259
Bone hyperpigmentation 11.10 9.88 4 221262 43 110367990
Pneumonia fungal 11.08 9.88 8 221258 14746 110353287
Amyotrophic lateral sclerosis 11.02 9.88 17 221249 2074 110365959
Peau d'orange 11.01 9.88 7 221259 283 110367750
Product dispensing error 11.01 9.88 63 221203 16282 110351751
Pituitary tumour recurrent 10.99 9.88 6 221260 182 110367851
Pulmonary mass 10.99 9.88 38 221228 37263 110330770
Alcohol use 10.97 9.88 25 221241 4097 110363936
Keratoacanthoma 10.95 9.88 14 221252 1434 110366599
Mixed dementia 10.95 9.88 7 221259 286 110367747
Left ventricular hypertrophy 10.94 9.88 54 221212 13190 110354843
Facial bones fracture 10.93 9.88 28 221238 4943 110363090
Rash vesicular 10.93 9.88 8 221258 14644 110353389
Muscle atrophy 10.92 9.88 54 221212 13200 110354833
Product prescribing issue 10.86 9.88 6 221260 12766 110355267
Sensitisation 10.86 9.88 25 221241 4126 110363907
Full blood count decreased 10.84 9.88 105 221161 31994 110336039
Rotator cuff syndrome 10.84 9.88 64 221202 16730 110351303
Rhinovirus infection 10.83 9.88 5 221261 11784 110356249
Gravitational oedema 10.81 9.88 16 221250 1882 110366151
Respiratory disorder 10.81 9.88 91 221175 71291 110296742
Spinal shock 10.78 9.88 4 221262 47 110367986
Blood potassium decreased 10.76 9.88 160 221106 53954 110314079
Blood osmolarity decreased 10.73 9.88 14 221252 1464 110366569
Colitis microscopic 10.64 9.88 54 221212 13340 110354693
Abdominal compartment syndrome 10.63 9.88 16 221250 1911 110366122
Haemorrhoidal haemorrhage 10.61 9.88 38 221228 8055 110359978
Clostridium difficile infection 10.58 9.88 61 221205 52068 110315965
Medication error 10.58 9.88 281 220985 105085 110262948
Polyneuropathy 10.56 9.88 31 221235 31981 110336052
Itching scar 10.55 9.88 4 221262 50 110367983
Sickle cell anaemia with crisis 10.55 9.88 3 221263 9542 110358491
Ecchymosis 10.51 9.88 65 221201 17273 110350760
Thyrotoxic periodic paralysis 10.48 9.88 6 221260 200 110367833
Injection site discomfort 10.43 9.88 34 221232 6873 110361160
Vascular access site pain 10.40 9.88 9 221257 586 110367447
Substance abuse 10.39 9.88 6 221260 12457 110355576
Artery dissection 10.36 9.88 8 221258 443 110367590
Forced vital capacity decreased 10.36 9.88 16 221250 1954 110366079
Resorption bone increased 10.32 9.88 14 221252 1520 110366513
Fibromuscular dysplasia 10.28 9.88 7 221259 318 110367715
Increased appetite 10.27 9.88 58 221208 14919 110353114
Pituitary haemorrhage 10.27 9.88 7 221259 319 110367714
Osteonecrosis 10.26 9.88 108 221158 33633 110334400
Carotid artery disease 10.24 9.88 17 221249 2206 110365827
Retinal infarction 10.24 9.88 6 221260 209 110367824
Foot deformity 10.24 9.88 56 221210 48424 110319609
Drug effective for unapproved indication 10.23 9.88 8 221258 14159 110353874
Non-cardiac chest pain 10.22 9.88 44 221222 10154 110357879
Cerebral infarction 10.21 9.88 153 221113 51685 110316348
Contusion 10.17 9.88 373 220893 232988 110135045
Anxiety 10.16 9.88 812 220454 344266 110023767
Bone infarction 10.15 9.88 9 221257 605 110367428
Monocyte count increased 10.14 9.88 53 221213 13240 110354793
Full blood count abnormal 10.13 9.88 68 221198 55984 110312049
Aortic aneurysm 10.13 9.88 43 221223 9861 110358172
Drug level above therapeutic 10.12 9.88 48 221218 11540 110356493
Nasal polyps 10.12 9.88 7 221259 13193 110354840
Stress cardiomyopathy 10.11 9.88 10 221256 15796 110352237
Systolic hypertension 10.08 9.88 11 221255 953 110367080
Atrial flutter 10.07 9.88 83 221183 24179 110343854
Pseudopolyposis 10.04 9.88 5 221261 125 110367908
Bronchial hyperreactivity 10.00 9.88 22 221244 3522 110364511
Prinzmetal angina 9.99 9.88 17 221249 2252 110365781
Renal tubular necrosis 9.96 9.88 99 221167 30376 110337657
Impaired work ability 9.91 9.88 24 221242 26395 110341638
Cardiac neoplasm unspecified 9.90 9.88 5 221261 129 110367904
Hallucinations, mixed 9.89 9.88 39 221227 8654 110359379

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07CB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07CB53 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07DB01 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, THIAZIDES AND OTHER DIURETICS
Beta blocking agents, selective, thiazides and other diuretics
ATC C07FB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35530 ฮฒ-adrenergic antagonist
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:66991 sympatholytic agent
CHEBI has role CHEBI:78298 environmental contaminant
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D013565 Sympatholytics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists

Related Drugs by ATC class:

C07AB Beta blocking agents, selective 13 drugs
acebutololbetaxololbevantololbisoprololceliprololepanololesatenololesmolollandiololmetoprololnebivololpractolol show all 13 →
C07BB Beta blocking agents, selective, and thiazides 5 drugs
acebutololbevantololbisoprololmetoprololnebivolol
C07CB Beta blocking agents, selective, and other diuretics 1 drug
metoprolol
C07FB Beta blocking agents and calcium channel blockers 6 drugs
amlodipinebisoprololfelodipinemetoprololnebivololnifedipine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Angina pectoris indication 194828000
Chronic heart failure off-label use 48447003
Atrial fibrillation off-label use 49436004 DOID:0060224
Thyrotoxicosis off-label use 90739004 DOID:7997
Mitral valve prolapse off-label use 409712001
Diastolic heart failure off-label use 418304008 DOID:9775
Essential tremor off-label use 609558009 DOID:4990
Pheochromocytoma Adjunct Therapy off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Migraine Prevention off-label use
Anuria contraindication 2472002 DOID:2983
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Complete atrioventricular block contraindication 27885002
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hypochloremic alkalosis contraindication 70134007
Oliguria contraindication 83128009
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Asthma contraindication 195967001 DOID:2841
Acute pancreatitis contraindication 197456007 DOID:2913
Raynaud's phenomenon contraindication 266261006
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
First Degree Atrioventricular Heart Block contraindication
Acutely Decompensated HF Requiring Parenteral Inotropic Therapy contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.92 acidic
pKa2 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.30 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Kd 5.80 WOMBAT-PK
Adenosine receptor A3 GPCR IC50 8.75 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 5.93 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.62 CHEMBL
Urease Enzyme IC50 4.19 CHEMBL

External reference:

IDSource
4018460 VUID
N0000146784 NUI
D00235 KEGG_DRUG
1202 RXNORM
C0004147 UMLSCUI
CHEBI:2904 CHEBI
2TN PDB_CHEM_ID
CHEMBL24 ChEMBL_ID
DB00335 DRUGBANK_ID
D001262 MESH_DESCRIPTOR_UI
2249 PUBCHEM_CID
548 IUPHAR_LIGAND_ID
3801 INN_ID
50VV3VW0TI UNII
353 MMSL
4225 MMSL
d00004 MMSL
4018460 VANDF
001855 NDDF
387506000 SNOMEDCT_US
87652004 SNOMEDCT_US
50VV3VW0TI INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0752 TABLET 50 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0753 TABLET 100 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0787 TABLET 25 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0218 TABLET 25 mg ORAL ANDA 20 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0231 TABLET 50 mg ORAL ANDA 20 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0757 TABLET 100 mg ORAL ANDA 20 sections
Atenolol and Chlorthalidone HUMAN PRESCRIPTION DRUG LABEL 2 0591-5782 TABLET 50 mg ORAL ANDA 17 sections
Atenolol and Chlorthalidone HUMAN PRESCRIPTION DRUG LABEL 2 0591-5783 TABLET 100 mg ORAL ANDA 17 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8372 TABLET 25 mg ORAL ANDA 13 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8373 TABLET 50 mg ORAL ANDA 13 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7187 TABLET 25 mg ORAL ANDA 20 sections
ATENOLOL AND CHLORTHALIDONE HUMAN PRESCRIPTION DRUG LABEL 2 10135-733 TABLET 50 mg ORAL ANDA 21 sections
ATENOLOL AND CHLORTHALIDONE HUMAN PRESCRIPTION DRUG LABEL 2 10135-734 TABLET 100 mg ORAL ANDA 21 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-031 TABLET 50 mg ORAL ANDA 18 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-126 TABLET 25 mg ORAL ANDA 18 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-127 TABLET 50 mg ORAL ANDA 17 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-134 TABLET 25 mg ORAL ANDA 17 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-167 TABLET 25 mg ORAL ANDA 18 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-171 TABLET 100 mg ORAL ANDA 17 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-586 TABLET 50 mg ORAL ANDA 18 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 12634-436 TABLET 50 mg ORAL ANDA 17 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 12634-604 TABLET 25 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 12634-605 TABLET 100 mg ORAL ANDA 18 sections
Atenolol Human Prescription Drug Label 1 13107-168 TABLET 25 mg ORAL ANDA 22 sections
Atenolol Human Prescription Drug Label 1 13107-169 TABLET 50 mg ORAL ANDA 22 sections
Atenolol Human Prescription Drug Label 1 13107-170 TABLET 100 mg ORAL ANDA 22 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 16590-256 TABLET 25 mg ORAL ANDA 11 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 16590-257 TABLET 50 mg ORAL ANDA 11 sections
Atenolol and Chlorthalidone HUMAN PRESCRIPTION DRUG LABEL 2 16714-936 TABLET 50 mg ORAL ANDA 16 sections
Atenolol and Chlorthalidone HUMAN PRESCRIPTION DRUG LABEL 2 16714-937 TABLET 100 mg ORAL ANDA 16 sections