levamlodipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 4099 103129-82-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levamlodipine malate
  • levamlodipine besylate
  • (S)-amlodipine
  • levamlodipine
  • levoamlodipine
  • l-Amlodipine
used to treat angina and hypertension
  • Molecular weight: 408.88
  • Formula: C20H25ClN2O5
  • CLOGP: 3.43
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.88
  • ALOGS: -4.74
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood urea increased 47.09 35.41 16 509 48774 79695089
Neutrophil count increased 46.32 35.41 14 511 29382 79714481
Lymphocyte count decreased 43.64 35.41 15 510 47274 79696589

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA17 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.0 Basic
pKa2 1.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
736178-83-9 SECONDARY_CAS_RN
150566-71-5 SECONDARY_CAS_RN
D08941 KEGG_DRUG
4039729 VANDF
C2717539 UMLSCUI
6UB PDB_CHEM_ID
CHEMBL2111097 ChEMBL_ID
CHEMBL2107350 ChEMBL_ID
DB09237 DRUGBANK_ID
C542574 MESH_SUPPLEMENTAL_RECORD_UI
C000711385 MESH_SUPPLEMENTAL_RECORD_UI
8835 INN_ID
0P6NLP6806 UNII
9822750 PUBCHEM_CID
2376944 RXNORM
360548 MMSL
d08466 MMSL
018248 NDDF
1217308000 SNOMEDCT_US
1217324004 SNOMEDCT_US
1217325003 SNOMEDCT_US

Pharmaceutical products:

None