Stem definition | Drug id | CAS RN |
---|---|---|
angiotensin II receptor antagonists, antihypertensive (non-peptidic) | 2806 | 137862-53-4 |
Dose | Unit | Route |
---|---|---|
80 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.18 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 13 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 10.50 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 23 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.49 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 9.50 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 22, 2000 | PMDA | Ciba-Geigy Japan | |
Dec. 23, 1996 | FDA | ||
Nov. 19, 2015 | EMA | Novartis Europharm Limited |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Blood pressure inadequately controlled | 376.61 | 9.70 | 187 | 111608 | 4193 | 50489136 |
Blood pressure increased | 322.34 | 9.70 | 826 | 110969 | 132306 | 50361023 |
Pemphigus | 222.97 | 9.70 | 10 | 111785 | 120156 | 50373173 |
Hyponatraemia | 214.67 | 9.70 | 579 | 111216 | 95560 | 50397769 |
Macular degeneration | 209.04 | 9.70 | 205 | 111590 | 14183 | 50479146 |
Off label use | 201.05 | 9.70 | 472 | 111323 | 473954 | 50019375 |
Glossodynia | 187.20 | 9.70 | 19 | 111776 | 115550 | 50377779 |
Systemic lupus erythematosus | 184.94 | 9.70 | 42 | 111753 | 140580 | 50352749 |
Myocardial infarction | 182.73 | 9.70 | 520 | 111275 | 88507 | 50404822 |
Hand deformity | 174.57 | 9.70 | 12 | 111783 | 100187 | 50393142 |
Cardiac failure congestive | 162.69 | 9.70 | 482 | 111313 | 83900 | 50409429 |
Hyperkalaemia | 157.36 | 9.70 | 336 | 111459 | 47753 | 50445576 |
Oligohydramnios | 155.53 | 9.70 | 117 | 111678 | 5633 | 50487696 |
Completed suicide | 150.01 | 9.70 | 52 | 111743 | 131837 | 50361492 |
Oedema peripheral | 139.61 | 9.70 | 704 | 111091 | 157257 | 50336072 |
Infusion related reaction | 136.36 | 9.70 | 105 | 111690 | 169452 | 50323877 |
Cerebral infarction | 132.96 | 9.70 | 199 | 111596 | 21405 | 50471924 |
Coronary artery disease | 124.08 | 9.70 | 230 | 111565 | 29496 | 50463833 |
Acute kidney injury | 123.20 | 9.70 | 894 | 110901 | 227164 | 50266165 |
Dizziness | 119.50 | 9.70 | 1229 | 110566 | 345140 | 50148189 |
Maternal exposure during pregnancy | 118.54 | 9.70 | 107 | 111688 | 159671 | 50333658 |
Alopecia | 117.50 | 9.70 | 227 | 111568 | 244820 | 50248509 |
Product use issue | 113.41 | 9.70 | 98 | 111697 | 149377 | 50343952 |
Contraindicated product administered | 112.60 | 9.70 | 98 | 111697 | 148860 | 50344469 |
Pericarditis | 110.70 | 9.70 | 20 | 111775 | 78669 | 50414660 |
Wound | 108.32 | 9.70 | 49 | 111746 | 105745 | 50387584 |
Hypertensive crisis | 103.00 | 9.70 | 136 | 111659 | 13018 | 50480311 |
Arthropathy | 101.02 | 9.70 | 120 | 111675 | 157786 | 50335543 |
Blood creatinine increased | 97.23 | 9.70 | 379 | 111416 | 75781 | 50417548 |
Therapeutic product effect decreased | 95.18 | 9.70 | 96 | 111699 | 135954 | 50357375 |
Colitis microscopic | 94.89 | 9.70 | 93 | 111702 | 6427 | 50486902 |
Renal failure | 93.95 | 9.70 | 475 | 111320 | 106158 | 50387171 |
Glaucoma | 92.99 | 9.70 | 142 | 111653 | 15544 | 50477785 |
Blood glucose increased | 91.91 | 9.70 | 356 | 111439 | 70968 | 50422361 |
Diabetes mellitus | 90.59 | 9.70 | 276 | 111519 | 48757 | 50444572 |
Pain | 89.67 | 9.70 | 833 | 110962 | 578070 | 49915259 |
Cerebrovascular accident | 89.27 | 9.70 | 430 | 111365 | 94250 | 50399079 |
Toxicity to various agents | 86.06 | 9.70 | 216 | 111579 | 212283 | 50281046 |
Syncope | 83.94 | 9.70 | 449 | 111346 | 102553 | 50390776 |
Treatment failure | 83.41 | 9.70 | 109 | 111686 | 137528 | 50355801 |
Hypotension | 82.22 | 9.70 | 838 | 110957 | 234631 | 50258698 |
Joint swelling | 81.36 | 9.70 | 274 | 111521 | 245012 | 50248317 |
Duodenal ulcer perforation | 80.79 | 9.70 | 5 | 111790 | 45606 | 50447723 |
Rash | 77.71 | 9.70 | 607 | 111188 | 436864 | 50056465 |
Atrial fibrillation | 76.52 | 9.70 | 434 | 111361 | 101311 | 50392018 |
Thyroid disorder | 74.07 | 9.70 | 114 | 111681 | 12563 | 50480766 |
Drug ineffective | 70.60 | 9.70 | 1332 | 110463 | 818001 | 49675328 |
Discomfort | 68.61 | 9.70 | 83 | 111712 | 108297 | 50385032 |
Swelling | 68.22 | 9.70 | 222 | 111573 | 200650 | 50292679 |
Cardiac failure | 67.14 | 9.70 | 339 | 111456 | 75701 | 50417628 |
Blood pressure decreased | 66.35 | 9.70 | 272 | 111523 | 55637 | 50437692 |
Product use in unapproved indication | 65.87 | 9.70 | 96 | 111699 | 115723 | 50377606 |
Angina pectoris | 63.74 | 9.70 | 163 | 111632 | 26025 | 50467304 |
Folliculitis | 62.07 | 9.70 | 7 | 111788 | 39218 | 50454111 |
Blood urea increased | 61.82 | 9.70 | 151 | 111644 | 23434 | 50469895 |
Drug intolerance | 59.61 | 9.70 | 265 | 111530 | 218839 | 50274490 |
Bronchial haemorrhage | 59.40 | 9.70 | 27 | 111768 | 493 | 50492836 |
Helicobacter infection | 59.29 | 9.70 | 18 | 111777 | 49684 | 50443645 |
Muscle injury | 57.79 | 9.70 | 7 | 111788 | 37104 | 50456225 |
Diabetes mellitus inadequate control | 57.74 | 9.70 | 104 | 111691 | 13041 | 50480288 |
Bronchial neoplasm | 57.54 | 9.70 | 25 | 111770 | 408 | 50492921 |
Synovitis | 56.49 | 9.70 | 118 | 111677 | 123747 | 50369582 |
Rheumatoid factor positive | 56.06 | 9.70 | 20 | 111775 | 49839 | 50443490 |
Fall | 55.41 | 9.70 | 1043 | 110752 | 333889 | 50159440 |
Condition aggravated | 54.14 | 9.70 | 409 | 111386 | 296649 | 50196680 |
Infection | 54.08 | 9.70 | 198 | 111597 | 172756 | 50320573 |
Exposure during pregnancy | 51.32 | 9.70 | 120 | 111675 | 120895 | 50372434 |
Rheumatoid arthritis | 50.95 | 9.70 | 252 | 111543 | 202298 | 50291031 |
Nasal turbinate hypertrophy | 50.00 | 9.70 | 26 | 111769 | 644 | 50492685 |
Hypertension | 49.97 | 9.70 | 698 | 111097 | 210505 | 50282824 |
Diverticulitis | 49.76 | 9.70 | 174 | 111621 | 33008 | 50460321 |
Fatigue | 48.95 | 9.70 | 1191 | 110604 | 706410 | 49786919 |
Blood pressure diastolic decreased | 46.73 | 9.70 | 110 | 111685 | 16671 | 50476658 |
Hyperuricaemia | 45.61 | 9.70 | 54 | 111741 | 4626 | 50488703 |
Intentional product use issue | 45.47 | 9.70 | 62 | 111733 | 76856 | 50416473 |
Total lung capacity increased | 45.24 | 9.70 | 25 | 111770 | 702 | 50492627 |
Product prescribing error | 44.47 | 9.70 | 124 | 111671 | 20837 | 50472492 |
Renal impairment | 44.47 | 9.70 | 303 | 111492 | 75358 | 50417971 |
Death | 44.43 | 9.70 | 482 | 111313 | 324897 | 50168432 |
Diverticulum intestinal | 44.39 | 9.70 | 60 | 111735 | 5873 | 50487456 |
Bronchial disorder | 44.34 | 9.70 | 29 | 111766 | 1113 | 50492216 |
Blister | 43.64 | 9.70 | 76 | 111719 | 85342 | 50407987 |
Abortion spontaneous | 43.28 | 9.70 | 19 | 111776 | 41753 | 50451576 |
Labile hypertension | 43.14 | 9.70 | 21 | 111774 | 450 | 50492879 |
Fear of disease | 42.78 | 9.70 | 26 | 111769 | 876 | 50492453 |
Haematoma | 42.35 | 9.70 | 156 | 111639 | 30354 | 50462975 |
Mitral valve incompetence | 41.75 | 9.70 | 108 | 111687 | 17363 | 50475966 |
Endometrial ablation | 41.25 | 9.70 | 25 | 111770 | 838 | 50492491 |
Drug abuse | 40.95 | 9.70 | 43 | 111752 | 59803 | 50433526 |
Asthenia | 40.82 | 9.70 | 957 | 110838 | 318085 | 50175244 |
Drug hypersensitivity | 40.04 | 9.70 | 358 | 111437 | 250652 | 50242677 |
Cardiovascular disorder | 40.04 | 9.70 | 78 | 111717 | 10376 | 50482953 |
Transient ischaemic attack | 40.03 | 9.70 | 159 | 111636 | 32051 | 50461278 |
Product dose omission issue | 40.01 | 9.70 | 240 | 111555 | 183598 | 50309731 |
Obstructive airways disorder | 38.69 | 9.70 | 98 | 111697 | 15554 | 50477775 |
Forced expiratory volume decreased | 38.43 | 9.70 | 48 | 111747 | 4346 | 50488983 |
Neutropenia | 38.40 | 9.70 | 182 | 111613 | 147783 | 50345546 |
Febrile neutropenia | 38.16 | 9.70 | 101 | 111694 | 97566 | 50395763 |
Arthralgia | 37.91 | 9.70 | 712 | 111083 | 437990 | 50055339 |
Blood uric acid increased | 36.97 | 9.70 | 44 | 111751 | 3790 | 50489539 |
Dehydration | 36.90 | 9.70 | 506 | 111289 | 151943 | 50341386 |
Tachyarrhythmia | 36.16 | 9.70 | 45 | 111750 | 4060 | 50489269 |
Pulmonary hypoplasia | 36.13 | 9.70 | 16 | 111779 | 274 | 50493055 |
Chest pain | 36.10 | 9.70 | 570 | 111225 | 176312 | 50317017 |
Acute myocardial infarction | 35.97 | 9.70 | 144 | 111651 | 29129 | 50464200 |
Rhonchi | 35.63 | 9.70 | 34 | 111761 | 2273 | 50491056 |
Cardiomegaly | 35.49 | 9.70 | 96 | 111699 | 15849 | 50477480 |
Chronic kidney disease | 34.87 | 9.70 | 177 | 111618 | 39594 | 50453735 |
Pregnancy | 34.76 | 9.70 | 11 | 111784 | 29566 | 50463763 |
Angioedema | 34.67 | 9.70 | 170 | 111625 | 37506 | 50455823 |
Skin reaction | 34.60 | 9.70 | 78 | 111717 | 11490 | 50481839 |
Sinusitis | 34.36 | 9.70 | 228 | 111567 | 170330 | 50322999 |
Abdominal discomfort | 34.10 | 9.70 | 337 | 111458 | 231304 | 50262025 |
Asthma | 34.04 | 9.70 | 324 | 111471 | 89013 | 50404316 |
Lymphatic fistula | 33.99 | 9.70 | 21 | 111774 | 729 | 50492600 |
Femoral hernia incarcerated | 33.71 | 9.70 | 21 | 111774 | 740 | 50492589 |
Musculoskeletal stiffness | 32.77 | 9.70 | 159 | 111636 | 128322 | 50365007 |
Pancreatic steatosis | 32.24 | 9.70 | 22 | 111773 | 907 | 50492422 |
Brain stem stroke | 32.03 | 9.70 | 14 | 111781 | 232 | 50493097 |
Blood sodium decreased | 31.80 | 9.70 | 111 | 111684 | 21036 | 50472293 |
Lower respiratory tract infection | 31.74 | 9.70 | 106 | 111689 | 95095 | 50398234 |
Blood pressure abnormal | 31.70 | 9.70 | 80 | 111715 | 12667 | 50480662 |
Product impurity | 31.46 | 9.70 | 9 | 111786 | 37 | 50493292 |
Ill-defined disorder | 31.35 | 9.70 | 45 | 111750 | 54609 | 50438720 |
Arrhythmia | 30.85 | 9.70 | 150 | 111645 | 32982 | 50460347 |
Angina unstable | 30.66 | 9.70 | 54 | 111741 | 6652 | 50486677 |
Anaemia | 30.65 | 9.70 | 752 | 111043 | 251704 | 50241625 |
Blood lactate dehydrogenase increased | 30.56 | 9.70 | 104 | 111691 | 19458 | 50473871 |
Vascular resistance pulmonary decreased | 30.17 | 9.70 | 10 | 111785 | 73 | 50493256 |
Arterial haemorrhage | 30.03 | 9.70 | 26 | 111769 | 1531 | 50491798 |
Psoriatic arthropathy | 29.77 | 9.70 | 36 | 111759 | 46996 | 50446333 |
Hip arthroplasty | 29.74 | 9.70 | 15 | 111780 | 30414 | 50462915 |
Nervousness | 29.29 | 9.70 | 130 | 111665 | 27521 | 50465808 |
Adverse drug reaction | 29.25 | 9.70 | 48 | 111747 | 55174 | 50438155 |
COVID-19 | 29.23 | 9.70 | 36 | 111759 | 46626 | 50446703 |
Blood pressure systolic increased | 29.16 | 9.70 | 155 | 111640 | 35294 | 50458035 |
Venous pressure jugular increased | 29.10 | 9.70 | 17 | 111778 | 532 | 50492797 |
Recalled product administered | 29.06 | 9.70 | 16 | 111779 | 446 | 50492883 |
Intentional overdose | 28.94 | 9.70 | 59 | 111736 | 62445 | 50430884 |
Migraine | 28.53 | 9.70 | 79 | 111716 | 75201 | 50418128 |
Hypochromic anaemia | 28.12 | 9.70 | 26 | 111769 | 1670 | 50491659 |
Hepatic enzyme increased | 27.98 | 9.70 | 183 | 111612 | 137197 | 50356132 |
Irritable bowel syndrome | 27.91 | 9.70 | 44 | 111751 | 51397 | 50441932 |
Injection site reaction | 27.91 | 9.70 | 42 | 111753 | 49990 | 50443339 |
Tricuspid valve incompetence | 27.54 | 9.70 | 76 | 111719 | 12694 | 50480635 |
Injection site pain | 27.39 | 9.70 | 139 | 111656 | 110885 | 50382444 |
Bradycardia | 27.25 | 9.70 | 239 | 111556 | 64187 | 50429142 |
Antinuclear antibody negative | 27.18 | 9.70 | 12 | 111783 | 204 | 50493125 |
Altered state of consciousness | 27.10 | 9.70 | 108 | 111687 | 21802 | 50471527 |
Breast cancer | 26.54 | 9.70 | 174 | 111621 | 42716 | 50450613 |
Gastrointestinal disorder | 26.40 | 9.70 | 113 | 111682 | 94343 | 50398986 |
Hypokalaemia | 26.38 | 9.70 | 304 | 111491 | 87688 | 50405641 |
Wound infection pseudomonas | 26.07 | 9.70 | 22 | 111773 | 1251 | 50492078 |
Disease progression | 26.00 | 9.70 | 116 | 111679 | 95750 | 50397579 |
Product contamination chemical | 25.59 | 9.70 | 5 | 111790 | 0 | 50493329 |
Blood potassium increased | 25.46 | 9.70 | 87 | 111708 | 16311 | 50477018 |
Thrombotic stroke | 25.46 | 9.70 | 15 | 111780 | 477 | 50492852 |
Left-to-right cardiac shunt | 25.42 | 9.70 | 10 | 111785 | 125 | 50493204 |
Hospitalisation | 25.23 | 9.70 | 72 | 111723 | 67865 | 50425464 |
Impaired healing | 25.16 | 9.70 | 75 | 111720 | 69711 | 50423618 |
Lymphocyte stimulation test positive | 25.07 | 9.70 | 15 | 111780 | 491 | 50492838 |
Blood creatine phosphokinase increased | 25.00 | 9.70 | 120 | 111675 | 26247 | 50467082 |
Product odour abnormal | 24.96 | 9.70 | 20 | 111775 | 1057 | 50492272 |
Coombs positive haemolytic anaemia | 24.85 | 9.70 | 13 | 111782 | 326 | 50493003 |
Hypertensive cardiomyopathy | 24.80 | 9.70 | 11 | 111784 | 189 | 50493140 |
Bundle branch block left | 24.49 | 9.70 | 47 | 111748 | 6183 | 50487146 |
Seroma | 24.47 | 9.70 | 25 | 111770 | 1816 | 50491513 |
Stomatitis | 24.36 | 9.70 | 128 | 111667 | 101216 | 50392113 |
Gastric ulcer haemorrhage | 24.36 | 9.70 | 39 | 111756 | 4445 | 50488884 |
Drug resistance | 24.29 | 9.70 | 6 | 111789 | 18983 | 50474346 |
Nasopharyngitis | 24.24 | 9.70 | 291 | 111504 | 192636 | 50300693 |
Atrioventricular block complete | 24.07 | 9.70 | 51 | 111744 | 7204 | 50486125 |
Hiatus hernia | 23.97 | 9.70 | 92 | 111703 | 18252 | 50475077 |
Peripheral swelling | 23.87 | 9.70 | 316 | 111479 | 205620 | 50287709 |
Sinus node dysfunction | 23.71 | 9.70 | 36 | 111759 | 3919 | 50489410 |
Aortic valve stenosis | 23.66 | 9.70 | 31 | 111764 | 2944 | 50490385 |
Hemiplegia | 23.47 | 9.70 | 51 | 111744 | 7330 | 50485999 |
Rhabdomyolysis | 23.34 | 9.70 | 157 | 111638 | 38870 | 50454459 |
Gamma-glutamyltransferase increased | 23.33 | 9.70 | 128 | 111667 | 29495 | 50463834 |
Renal cyst | 23.17 | 9.70 | 56 | 111739 | 8631 | 50484698 |
Dyschezia | 23.08 | 9.70 | 24 | 111771 | 1780 | 50491549 |
Metastatic bronchial carcinoma | 23.06 | 9.70 | 9 | 111786 | 110 | 50493219 |
Liver function test increased | 23.03 | 9.70 | 14 | 111781 | 25592 | 50467737 |
Spinal osteoarthritis | 22.97 | 9.70 | 76 | 111719 | 14016 | 50479313 |
Forced vital capacity decreased | 22.93 | 9.70 | 18 | 111777 | 923 | 50492406 |
Coronary artery stenosis | 22.88 | 9.70 | 37 | 111758 | 4252 | 50489077 |
Renal artery stenosis | 22.76 | 9.70 | 23 | 111772 | 1649 | 50491680 |
Basal ganglion degeneration | 22.60 | 9.70 | 13 | 111782 | 395 | 50492934 |
Concomitant disease progression | 22.29 | 9.70 | 25 | 111770 | 2020 | 50491309 |
Gastrointestinal haemorrhage | 22.28 | 9.70 | 254 | 111541 | 73067 | 50420262 |
Hypoglycaemia | 22.26 | 9.70 | 198 | 111597 | 53383 | 50439946 |
Ventricular extrasystoles | 22.10 | 9.70 | 62 | 111733 | 10454 | 50482875 |
Myocardial ischaemia | 22.03 | 9.70 | 66 | 111729 | 11547 | 50481782 |
Injection site erythema | 21.97 | 9.70 | 88 | 111707 | 74848 | 50418481 |
Coronary arterial stent insertion | 21.81 | 9.70 | 28 | 111767 | 2606 | 50490723 |
Acral lentiginous melanoma | 21.66 | 9.70 | 5 | 111790 | 6 | 50493323 |
Dementia Alzheimer's type | 21.44 | 9.70 | 18 | 111777 | 1016 | 50492313 |
Tissue infiltration | 21.37 | 9.70 | 14 | 111781 | 539 | 50492790 |
Live birth | 21.35 | 9.70 | 5 | 111790 | 16403 | 50476926 |
Frustration tolerance decreased | 21.32 | 9.70 | 42 | 111753 | 5632 | 50487697 |
Multiple sclerosis relapse | 21.24 | 9.70 | 39 | 111756 | 42925 | 50450404 |
Hypochloraemia | 21.23 | 9.70 | 22 | 111773 | 1625 | 50491704 |
Gastritis haemorrhagic | 21.21 | 9.70 | 20 | 111775 | 1317 | 50492012 |
Complex regional pain syndrome | 21.10 | 9.70 | 24 | 111771 | 1969 | 50491360 |
Ophthalmic vein thrombosis | 20.76 | 9.70 | 9 | 111786 | 146 | 50493183 |
Neonatal seizure | 20.70 | 9.70 | 12 | 111783 | 370 | 50492959 |
Pneumothorax traumatic | 20.33 | 9.70 | 9 | 111786 | 154 | 50493175 |
Hepatic cyst | 20.31 | 9.70 | 36 | 111759 | 4457 | 50488872 |
Herpes simplex reactivation | 20.27 | 9.70 | 12 | 111783 | 385 | 50492944 |
Faecaloma | 20.23 | 9.70 | 47 | 111748 | 7061 | 50486268 |
Impaired work ability | 20.22 | 9.70 | 3 | 111792 | 13637 | 50479692 |
Lung diffusion test decreased | 20.14 | 9.70 | 14 | 111781 | 595 | 50492734 |
Loss of consciousness | 20.04 | 9.70 | 333 | 111462 | 104020 | 50389309 |
Colon cancer | 20.02 | 9.70 | 53 | 111742 | 8638 | 50484691 |
Retrograde amnesia | 19.89 | 9.70 | 12 | 111783 | 399 | 50492930 |
Ear infection | 19.70 | 9.70 | 17 | 111778 | 25953 | 50467376 |
C-reactive protein increased | 19.63 | 9.70 | 229 | 111566 | 66245 | 50427084 |
Coronary artery occlusion | 19.62 | 9.70 | 48 | 111747 | 7455 | 50485874 |
Therapy interrupted | 19.59 | 9.70 | 10 | 111785 | 20142 | 50473187 |
Monocyte count abnormal | 19.52 | 9.70 | 9 | 111786 | 170 | 50493159 |
Psychotic disorder | 19.51 | 9.70 | 12 | 111783 | 21800 | 50471529 |
Cough | 19.47 | 9.70 | 683 | 111112 | 240581 | 50252748 |
Diabetic nephropathy | 19.30 | 9.70 | 19 | 111776 | 1320 | 50492009 |
Multiple injuries | 19.05 | 9.70 | 21 | 111774 | 1665 | 50491664 |
Suicidal ideation | 18.91 | 9.70 | 61 | 111734 | 55324 | 50438005 |
Nephrogenic anaemia | 18.85 | 9.70 | 21 | 111774 | 1684 | 50491645 |
Withdrawal hypertension | 18.67 | 9.70 | 8 | 111787 | 126 | 50493203 |
Hypertensive heart disease | 18.59 | 9.70 | 24 | 111771 | 2246 | 50491083 |
Ischaemic stroke | 18.44 | 9.70 | 77 | 111718 | 15871 | 50477458 |
Rectal prolapse | 18.42 | 9.70 | 21 | 111774 | 1728 | 50491601 |
Myalgia | 18.41 | 9.70 | 381 | 111414 | 123938 | 50369391 |
Lacunar infarction | 18.37 | 9.70 | 28 | 111767 | 3059 | 50490270 |
Peak expiratory flow rate decreased | 18.24 | 9.70 | 13 | 111782 | 575 | 50492754 |
Neutrophil function disorder | 18.22 | 9.70 | 5 | 111790 | 17 | 50493312 |
Cardiac failure chronic | 18.01 | 9.70 | 30 | 111765 | 3533 | 50489796 |
No adverse event | 17.95 | 9.70 | 29 | 111766 | 33549 | 50459780 |
Intestinal polyp | 17.77 | 9.70 | 17 | 111778 | 1140 | 50492189 |
Feeling abnormal | 17.74 | 9.70 | 382 | 111413 | 125110 | 50368219 |
Device dislocation | 17.73 | 9.70 | 13 | 111782 | 21533 | 50471796 |
Iron deficiency anaemia | 17.72 | 9.70 | 79 | 111716 | 16755 | 50476574 |
Cardiac failure acute | 17.69 | 9.70 | 49 | 111746 | 8201 | 50485128 |
Urine albumin/creatinine ratio increased | 17.68 | 9.70 | 9 | 111786 | 213 | 50493116 |
Monoplegia | 17.64 | 9.70 | 26 | 111769 | 2757 | 50490572 |
Cardiac pacemaker insertion | 17.46 | 9.70 | 30 | 111765 | 3623 | 50489706 |
Therapeutic drug monitoring analysis incorrectly performed | 17.45 | 9.70 | 8 | 111787 | 149 | 50493180 |
Stenosis | 17.45 | 9.70 | 17 | 111778 | 1166 | 50492163 |
Gastric cancer | 17.43 | 9.70 | 27 | 111768 | 2991 | 50490338 |
Interstitial lung disease | 17.43 | 9.70 | 187 | 111608 | 52989 | 50440340 |
Renin decreased | 17.35 | 9.70 | 7 | 111788 | 94 | 50493235 |
Inguinal hernia | 17.15 | 9.70 | 20 | 111775 | 1686 | 50491643 |
Glycosylated haemoglobin increased | 17.11 | 9.70 | 57 | 111738 | 10549 | 50482780 |
Uterine enlargement | 17.01 | 9.70 | 16 | 111779 | 1050 | 50492279 |
Aortic arteriosclerosis | 16.90 | 9.70 | 37 | 111758 | 5345 | 50487984 |
Hypertensive emergency | 16.85 | 9.70 | 19 | 111776 | 1544 | 50491785 |
Kyphosis | 16.85 | 9.70 | 23 | 111772 | 2272 | 50491057 |
Post-anoxic myoclonus | 16.85 | 9.70 | 5 | 111790 | 24 | 50493305 |
Transitional cell cancer of the renal pelvis and ureter | 16.82 | 9.70 | 4 | 111791 | 6 | 50493323 |
Hyponatraemic syndrome | 16.82 | 9.70 | 12 | 111783 | 532 | 50492797 |
Haemarthrosis | 16.77 | 9.70 | 26 | 111769 | 2882 | 50490447 |
Arteriosclerosis | 16.66 | 9.70 | 51 | 111744 | 9026 | 50484303 |
Infarction | 16.60 | 9.70 | 23 | 111772 | 2305 | 50491024 |
Loss of personal independence in daily activities | 16.54 | 9.70 | 89 | 111706 | 69961 | 50423368 |
Cardiac disorder | 16.42 | 9.70 | 156 | 111639 | 42823 | 50450506 |
Intentional product misuse | 16.29 | 9.70 | 51 | 111744 | 46683 | 50446646 |
Dyspnoea | 16.22 | 9.70 | 1412 | 110383 | 546196 | 49947133 |
Gout | 16.21 | 9.70 | 59 | 111736 | 11411 | 50481918 |
Ventricular hypertrophy | 16.16 | 9.70 | 27 | 111768 | 3188 | 50490141 |
Anaphylactic reaction | 16.14 | 9.70 | 63 | 111732 | 53992 | 50439337 |
Anaesthesia | 16.11 | 9.70 | 10 | 111785 | 350 | 50492979 |
Drug ineffective for unapproved indication | 16.06 | 9.70 | 14 | 111781 | 21267 | 50472062 |
Melaena | 16.02 | 9.70 | 108 | 111687 | 26756 | 50466573 |
Breast neoplasm | 15.96 | 9.70 | 17 | 111778 | 1296 | 50492033 |
Lipoedema | 15.93 | 9.70 | 9 | 111786 | 264 | 50493065 |
Fear | 15.86 | 9.70 | 69 | 111726 | 14480 | 50478849 |
Bronchitis | 15.67 | 9.70 | 320 | 111475 | 103839 | 50389490 |
Bone marrow failure | 15.59 | 9.70 | 23 | 111772 | 27601 | 50465728 |
Malaise | 15.43 | 9.70 | 897 | 110898 | 334635 | 50158694 |
Carotid artery disease | 15.40 | 9.70 | 18 | 111777 | 1521 | 50491808 |
Body height decreased | 15.38 | 9.70 | 49 | 111746 | 8859 | 50484470 |
Coronary artery bypass | 15.38 | 9.70 | 22 | 111773 | 2271 | 50491058 |
Intentional self-injury | 15.37 | 9.70 | 17 | 111778 | 23095 | 50470234 |
Diapedesis | 15.35 | 9.70 | 3 | 111792 | 0 | 50493329 |
Hypersensitivity | 15.34 | 9.70 | 360 | 111435 | 214801 | 50278528 |
Angiotensin converting enzyme inhibitor foetopathy | 15.27 | 9.70 | 5 | 111790 | 35 | 50493294 |
Multiple drug therapy | 15.12 | 9.70 | 20 | 111775 | 1917 | 50491412 |
Palpitations | 15.11 | 9.70 | 293 | 111502 | 94213 | 50399116 |
Nodal rhythm | 14.95 | 9.70 | 18 | 111777 | 1569 | 50491760 |
Gastrointestinal stromal tumour | 14.91 | 9.70 | 14 | 111781 | 917 | 50492412 |
Malignant neoplasm progression | 14.76 | 9.70 | 89 | 111706 | 68035 | 50425294 |
Brain contusion | 14.59 | 9.70 | 11 | 111784 | 531 | 50492798 |
Cranial sutures widening | 14.48 | 9.70 | 4 | 111791 | 14 | 50493315 |
Incorrect route of product administration | 14.43 | 9.70 | 12 | 111783 | 18654 | 50474675 |
Gingival ulceration | 14.41 | 9.70 | 13 | 111782 | 809 | 50492520 |
Mydriasis | 14.31 | 9.70 | 3 | 111792 | 10624 | 50482705 |
General physical health deterioration | 14.30 | 9.70 | 414 | 111381 | 142020 | 50351309 |
Pyometra | 14.27 | 9.70 | 6 | 111789 | 90 | 50493239 |
Blood pressure fluctuation | 14.17 | 9.70 | 131 | 111664 | 35692 | 50457637 |
Pyrexia | 14.16 | 9.70 | 691 | 111104 | 379512 | 50113817 |
Renal cell carcinoma | 14.12 | 9.70 | 25 | 111770 | 3092 | 50490237 |
Product contamination | 14.10 | 9.70 | 11 | 111784 | 559 | 50492770 |
Hyperlipidaemia | 14.06 | 9.70 | 76 | 111719 | 17414 | 50475915 |
Device issue | 14.06 | 9.70 | 14 | 111781 | 19958 | 50473371 |
Status epilepticus | 14.04 | 9.70 | 6 | 111789 | 13400 | 50479929 |
Subarachnoid haemorrhage | 14.04 | 9.70 | 54 | 111741 | 10722 | 50482607 |
Cataract | 13.98 | 9.70 | 163 | 111632 | 47137 | 50446192 |
Coronary angioplasty | 13.97 | 9.70 | 6 | 111789 | 95 | 50493234 |
Antiphospholipid syndrome | 13.96 | 9.70 | 17 | 111778 | 1500 | 50491829 |
Blood aldosterone increased | 13.89 | 9.70 | 7 | 111788 | 162 | 50493167 |
Visual acuity reduced | 13.88 | 9.70 | 84 | 111711 | 20055 | 50473274 |
Left ventricular hypertrophy | 13.75 | 9.70 | 32 | 111763 | 4813 | 50488516 |
Granuloma | 13.69 | 9.70 | 32 | 111763 | 4826 | 50488503 |
Hepatic function abnormal | 13.69 | 9.70 | 121 | 111674 | 32560 | 50460769 |
Bezold-Jarisch reflex | 13.69 | 9.70 | 4 | 111791 | 18 | 50493311 |
Mobility decreased | 13.62 | 9.70 | 112 | 111683 | 79836 | 50413493 |
Product taste abnormal | 13.59 | 9.70 | 18 | 111777 | 1727 | 50491602 |
Chronic obstructive pulmonary disease | 13.58 | 9.70 | 179 | 111616 | 53256 | 50440073 |
Injection site swelling | 13.58 | 9.70 | 47 | 111748 | 41726 | 50451603 |
Gastroenteritis | 13.53 | 9.70 | 93 | 111702 | 23188 | 50470141 |
Haematochezia | 13.42 | 9.70 | 141 | 111654 | 39741 | 50453588 |
Mouth ulceration | 13.36 | 9.70 | 26 | 111769 | 27998 | 50465331 |
Carpal tunnel syndrome | 13.30 | 9.70 | 73 | 111722 | 16820 | 50476509 |
Fabry's disease | 13.28 | 9.70 | 3 | 111792 | 3 | 50493326 |
Ulcer | 13.28 | 9.70 | 15 | 111780 | 20185 | 50473144 |
Renal neoplasm | 13.12 | 9.70 | 14 | 111781 | 1070 | 50492259 |
Diabetic retinopathy | 13.09 | 9.70 | 20 | 111775 | 2190 | 50491139 |
Merycism | 13.08 | 9.70 | 7 | 111788 | 184 | 50493145 |
Eructation | 13.06 | 9.70 | 40 | 111755 | 7081 | 50486248 |
Arrhythmogenic right ventricular dysplasia | 13.03 | 9.70 | 4 | 111791 | 22 | 50493307 |
Asthmatic crisis | 13.00 | 9.70 | 17 | 111778 | 1611 | 50491718 |
Urticaria chronic | 12.98 | 9.70 | 10 | 111785 | 499 | 50492830 |
Prosthesis implantation | 12.97 | 9.70 | 5 | 111790 | 59 | 50493270 |
Brain natriuretic peptide increased | 12.96 | 9.70 | 30 | 111765 | 4497 | 50488832 |
Renal cancer | 12.85 | 9.70 | 26 | 111769 | 3554 | 50489775 |
Myelosuppression | 12.71 | 9.70 | 7 | 111788 | 13510 | 50479819 |
Therapeutic product effect incomplete | 12.67 | 9.70 | 135 | 111660 | 91380 | 50401949 |
Skin texture abnormal | 12.67 | 9.70 | 9 | 111786 | 396 | 50492933 |
Respiration abnormal | 12.67 | 9.70 | 32 | 111763 | 5070 | 50488259 |
Pulmonary thrombosis | 12.59 | 9.70 | 41 | 111754 | 7500 | 50485829 |
Low density lipoprotein increased | 12.57 | 9.70 | 34 | 111761 | 5612 | 50487717 |
Swollen tongue | 12.51 | 9.70 | 107 | 111688 | 28523 | 50464806 |
Deafness | 12.49 | 9.70 | 68 | 111727 | 15623 | 50477706 |
Sedation | 12.45 | 9.70 | 31 | 111764 | 30579 | 50462750 |
Sinus arrest | 12.44 | 9.70 | 17 | 111778 | 1681 | 50491648 |
Ischaemic cardiomyopathy | 12.41 | 9.70 | 20 | 111775 | 2292 | 50491037 |
Stress cardiomyopathy | 12.38 | 9.70 | 42 | 111753 | 7845 | 50485484 |
Neutropenic sepsis | 12.35 | 9.70 | 8 | 111787 | 14139 | 50479190 |
Fixed eruption | 12.27 | 9.70 | 12 | 111783 | 827 | 50492502 |
Metastases to bone | 12.23 | 9.70 | 13 | 111782 | 17982 | 50475347 |
Bradycardia neonatal | 12.18 | 9.70 | 12 | 111783 | 834 | 50492495 |
Cytomegalovirus infection | 12.18 | 9.70 | 13 | 111782 | 17949 | 50475380 |
Cardiac myxoma | 12.16 | 9.70 | 7 | 111788 | 213 | 50493116 |
Postural tremor | 12.13 | 9.70 | 7 | 111788 | 214 | 50493115 |
Osteoarthritis | 12.11 | 9.70 | 216 | 111579 | 68390 | 50424939 |
Upper-airway cough syndrome | 12.10 | 9.70 | 44 | 111751 | 8506 | 50484823 |
Lymphostasis | 12.07 | 9.70 | 3 | 111792 | 6 | 50493323 |
Therapeutic drug monitoring analysis not performed | 12.06 | 9.70 | 11 | 111784 | 694 | 50492635 |
Marasmus | 12.00 | 9.70 | 9 | 111786 | 431 | 50492898 |
Groin pain | 11.95 | 9.70 | 45 | 111750 | 8846 | 50484483 |
Occult blood positive | 11.93 | 9.70 | 24 | 111771 | 3267 | 50490062 |
Blood sodium increased | 11.84 | 9.70 | 20 | 111775 | 2382 | 50490947 |
Ligament injury | 11.82 | 9.70 | 13 | 111782 | 1028 | 50492301 |
Movement disorder | 11.81 | 9.70 | 73 | 111722 | 17559 | 50475770 |
Hypertensive encephalopathy | 11.77 | 9.70 | 10 | 111785 | 574 | 50492755 |
Gastritis | 11.76 | 9.70 | 118 | 111677 | 32865 | 50460464 |
Heat illness | 11.67 | 9.70 | 6 | 111789 | 145 | 50493184 |
Hypercholesterolaemia | 11.63 | 9.70 | 54 | 111741 | 11649 | 50481680 |
Inflammatory marker increased | 11.63 | 9.70 | 33 | 111762 | 5601 | 50487728 |
Microalbuminuria | 11.57 | 9.70 | 8 | 111787 | 337 | 50492992 |
Multi-organ disorder | 11.46 | 9.70 | 14 | 111781 | 1239 | 50492090 |
Duodenal ulcer | 11.46 | 9.70 | 37 | 111758 | 6738 | 50486591 |
Hyperglycaemia | 11.46 | 9.70 | 127 | 111668 | 36278 | 50457051 |
Therapy non-responder | 11.40 | 9.70 | 66 | 111729 | 50956 | 50442373 |
Cutaneous lymphoma | 11.38 | 9.70 | 6 | 111789 | 153 | 50493176 |
Cardiogenic shock | 11.35 | 9.70 | 66 | 111729 | 15533 | 50477796 |
Affective disorder | 11.34 | 9.70 | 31 | 111764 | 5150 | 50488179 |
Coronary artery restenosis | 11.32 | 9.70 | 8 | 111787 | 349 | 50492980 |
Gastrointestinal cancer metastatic | 11.27 | 9.70 | 5 | 111790 | 86 | 50493243 |
Cerebral haemorrhage | 11.25 | 9.70 | 100 | 111695 | 26952 | 50466377 |
Product substitution issue | 11.24 | 9.70 | 61 | 111734 | 13996 | 50479333 |
Ear pain | 11.23 | 9.70 | 29 | 111766 | 28254 | 50465075 |
Perihepatic discomfort | 11.21 | 9.70 | 3 | 111792 | 9 | 50493320 |
Knee arthroplasty | 11.21 | 9.70 | 41 | 111754 | 35805 | 50457524 |
Seizure | 11.18 | 9.70 | 188 | 111607 | 117686 | 50375643 |
Dyspnoea exertional | 11.16 | 9.70 | 167 | 111628 | 51066 | 50442263 |
Erysipelas | 11.10 | 9.70 | 36 | 111759 | 6572 | 50486757 |
Disease recurrence | 11.06 | 9.70 | 17 | 111778 | 20064 | 50473265 |
Carotid artery stenosis | 11.05 | 9.70 | 29 | 111766 | 4702 | 50488627 |
Pollakiuria | 10.88 | 9.70 | 90 | 111705 | 23761 | 50469568 |
Therapy cessation | 10.85 | 9.70 | 26 | 111769 | 25985 | 50467344 |
Pulmonary oedema | 10.85 | 9.70 | 160 | 111635 | 48778 | 50444551 |
Hepatic cancer | 10.84 | 9.70 | 23 | 111772 | 3252 | 50490077 |
Cell marker increased | 10.76 | 9.70 | 7 | 111788 | 266 | 50493063 |
Infusion site pain | 10.76 | 9.70 | 7 | 111788 | 12339 | 50480990 |
Cerebral arteriosclerosis | 10.74 | 9.70 | 7 | 111788 | 267 | 50493062 |
Catheterisation cardiac | 10.73 | 9.70 | 26 | 111769 | 4014 | 50489315 |
Skin ulcer | 10.65 | 9.70 | 41 | 111754 | 35277 | 50458052 |
Atrioventricular block | 10.61 | 9.70 | 35 | 111760 | 6443 | 50486886 |
Eye haemorrhage | 10.59 | 9.70 | 38 | 111757 | 7297 | 50486032 |
Renal disorder | 10.59 | 9.70 | 100 | 111695 | 27405 | 50465924 |
Dementia | 10.57 | 9.70 | 66 | 111729 | 15931 | 50477398 |
Anuria | 10.53 | 9.70 | 51 | 111744 | 11193 | 50482136 |
Hot flush | 10.49 | 9.70 | 56 | 111739 | 44113 | 50449216 |
Overdose | 10.48 | 9.70 | 156 | 111639 | 99571 | 50393758 |
Ankle fracture | 10.47 | 9.70 | 65 | 111730 | 15657 | 50477672 |
Adverse reaction | 10.44 | 9.70 | 3 | 111792 | 8583 | 50484746 |
Lymphocyte count decreased | 10.42 | 9.70 | 27 | 111768 | 26280 | 50467049 |
Polyuria | 10.38 | 9.70 | 37 | 111758 | 7084 | 50486245 |
Parkinson's disease | 10.37 | 9.70 | 13 | 111782 | 1182 | 50492147 |
Duodenal polyp | 10.36 | 9.70 | 5 | 111790 | 105 | 50493224 |
Oedema | 10.35 | 9.70 | 215 | 111580 | 69966 | 50423363 |
Mood swings | 10.32 | 9.70 | 12 | 111783 | 15942 | 50477387 |
Cutaneous listeriosis | 10.32 | 9.70 | 4 | 111791 | 48 | 50493281 |
Neuropathy peripheral | 10.29 | 9.70 | 151 | 111644 | 96606 | 50396723 |
Panniculitis | 10.28 | 9.70 | 3 | 111792 | 8500 | 50484829 |
Blood chloride decreased | 10.18 | 9.70 | 29 | 111766 | 4932 | 50488397 |
Acute phosphate nephropathy | 10.18 | 9.70 | 3 | 111792 | 14 | 50493315 |
Mesothelioma malignant | 10.17 | 9.70 | 4 | 111791 | 50 | 50493279 |
Clostridium difficile infection | 10.16 | 9.70 | 26 | 111769 | 25413 | 50467916 |
Haemorrhage subcutaneous | 10.16 | 9.70 | 20 | 111775 | 2681 | 50490648 |
Large intestinal ulcer haemorrhage | 10.15 | 9.70 | 5 | 111790 | 110 | 50493219 |
Anxiety disorder | 10.14 | 9.70 | 24 | 111771 | 3649 | 50489680 |
Breath sounds abnormal | 10.11 | 9.70 | 39 | 111756 | 7753 | 50485576 |
Device related infection | 10.09 | 9.70 | 19 | 111776 | 20716 | 50472613 |
Renal artery stent placement | 10.07 | 9.70 | 5 | 111790 | 112 | 50493217 |
Liver disorder | 10.01 | 9.70 | 126 | 111669 | 37096 | 50456233 |
Eczema | 10.00 | 9.70 | 85 | 111710 | 22617 | 50470712 |
Meniere's disease | 9.93 | 9.70 | 6 | 111789 | 200 | 50493129 |
Dysaesthesia | 9.88 | 9.70 | 24 | 111771 | 3711 | 50489618 |
Caesarean section | 9.86 | 9.70 | 12 | 111783 | 15627 | 50477702 |
Brain stem haemorrhage | 9.86 | 9.70 | 10 | 111785 | 720 | 50492609 |
Carcinogenicity | 9.85 | 9.70 | 3 | 111792 | 16 | 50493313 |
Hydrothorax | 9.85 | 9.70 | 10 | 111785 | 721 | 50492608 |
Diverticulum | 9.84 | 9.70 | 48 | 111747 | 10566 | 50482763 |
Inappropriate antidiuretic hormone secretion | 9.82 | 9.70 | 56 | 111739 | 13087 | 50480242 |
Haematuria | 9.80 | 9.70 | 93 | 111702 | 25520 | 50467809 |
Gait disturbance | 9.79 | 9.70 | 415 | 111380 | 149590 | 50343739 |
Septic shock | 9.78 | 9.70 | 80 | 111715 | 57095 | 50436234 |
Varicose vein ruptured | 9.76 | 9.70 | 4 | 111791 | 56 | 50493273 |
Pigmentation disorder | 9.76 | 9.70 | 24 | 111771 | 3740 | 50489589 |
Invasive ductal breast carcinoma | 9.71 | 9.70 | 32 | 111763 | 5889 | 50487440 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 217.69 | 10.35 | 293 | 78876 | 300507 | 29194851 |
Blood pressure inadequately controlled | 209.54 | 10.35 | 110 | 79059 | 2276 | 29493082 |
Drug abuse | 179.82 | 10.35 | 8 | 79161 | 79875 | 29415483 |
Blood pressure increased | 171.84 | 10.35 | 510 | 78659 | 73293 | 29422065 |
Death | 129.52 | 10.35 | 476 | 78693 | 341608 | 29153750 |
Blood creatinine increased | 127.71 | 10.35 | 508 | 78661 | 84594 | 29410764 |
Cerebral infarction | 115.76 | 10.35 | 224 | 78945 | 24451 | 29470907 |
Toxicity to various agents | 111.77 | 10.35 | 183 | 78986 | 173478 | 29321880 |
Drug ineffective | 97.81 | 10.35 | 572 | 78597 | 362598 | 29132760 |
Hyperkalaemia | 97.34 | 10.35 | 373 | 78796 | 61019 | 29434339 |
Completed suicide | 95.46 | 10.35 | 62 | 79107 | 90184 | 29405174 |
Myocardial infarction | 87.81 | 10.35 | 550 | 78619 | 109746 | 29385612 |
Blood urea increased | 87.13 | 10.35 | 216 | 78953 | 27896 | 29467462 |
Cardiac failure | 72.44 | 10.35 | 410 | 78759 | 78877 | 29416481 |
Febrile neutropenia | 71.45 | 10.35 | 119 | 79050 | 112121 | 29383237 |
Hypertensive crisis | 69.39 | 10.35 | 95 | 79074 | 7753 | 29487605 |
Renal failure | 66.23 | 10.35 | 543 | 78626 | 118056 | 29377302 |
Neutropenia | 64.05 | 10.35 | 163 | 79006 | 131548 | 29363810 |
Dizziness | 60.92 | 10.35 | 775 | 78394 | 188909 | 29306449 |
Product use in unapproved indication | 59.17 | 10.35 | 88 | 79081 | 86787 | 29408571 |
Cerebrovascular accident | 58.35 | 10.35 | 379 | 78790 | 76532 | 29418826 |
Fear of disease | 55.60 | 10.35 | 22 | 79147 | 227 | 29495131 |
Syncope | 52.85 | 10.35 | 386 | 78783 | 80985 | 29414373 |
Cardiac failure congestive | 52.47 | 10.35 | 368 | 78801 | 76213 | 29419145 |
Angina pectoris | 52.40 | 10.35 | 179 | 78990 | 27671 | 29467687 |
Product dose omission issue | 48.61 | 10.35 | 117 | 79052 | 96266 | 29399092 |
Angioedema | 48.17 | 10.35 | 191 | 78978 | 31724 | 29463634 |
Acute myocardial infarction | 46.55 | 10.35 | 254 | 78915 | 48184 | 29447174 |
Treatment failure | 45.38 | 10.35 | 21 | 79148 | 36918 | 29458440 |
Renal impairment | 44.61 | 10.35 | 371 | 78798 | 80962 | 29414396 |
Interstitial lung disease | 43.49 | 10.35 | 284 | 78885 | 57434 | 29437924 |
Sepsis | 40.75 | 10.35 | 220 | 78949 | 142462 | 29352896 |
Hospitalisation | 40.49 | 10.35 | 38 | 79131 | 45950 | 29449408 |
Blood pressure diastolic decreased | 39.54 | 10.35 | 69 | 79100 | 6953 | 29488405 |
Blood lactic acid | 39.33 | 10.35 | 19 | 79150 | 327 | 29495031 |
Blood creatine phosphokinase increased | 38.29 | 10.35 | 212 | 78957 | 40432 | 29454926 |
Eosinophilic colitis | 38.14 | 10.35 | 16 | 79153 | 194 | 29495164 |
Coronary artery disease | 37.38 | 10.35 | 224 | 78945 | 43966 | 29451392 |
Cardiac failure chronic | 37.01 | 10.35 | 64 | 79105 | 6403 | 29488955 |
Oxygen saturation increased | 36.47 | 10.35 | 17 | 79152 | 269 | 29495089 |
Blood pressure decreased | 35.62 | 10.35 | 226 | 78943 | 45251 | 29450107 |
Lymphocyte stimulation test positive | 34.04 | 10.35 | 22 | 79147 | 679 | 29494679 |
Bundle branch block left | 33.90 | 10.35 | 55 | 79114 | 5222 | 29490136 |
Product impurity | 33.67 | 10.35 | 10 | 79159 | 38 | 29495320 |
Aortic aneurysm | 33.58 | 10.35 | 60 | 79109 | 6160 | 29489198 |
Product use issue | 33.20 | 10.35 | 54 | 79115 | 51390 | 29443968 |
Intentional product use issue | 33.05 | 10.35 | 39 | 79130 | 42459 | 29452899 |
Gamma-glutamyltransferase increased | 32.60 | 10.35 | 150 | 79019 | 26587 | 29468771 |
Arrhythmia | 31.98 | 10.35 | 167 | 79002 | 31146 | 29464212 |
Blood glucose increased | 31.76 | 10.35 | 268 | 78901 | 58716 | 29436642 |
Brain natriuretic peptide abnormal | 31.60 | 10.35 | 16 | 79153 | 306 | 29495052 |
Fractured coccyx | 31.49 | 10.35 | 13 | 79156 | 151 | 29495207 |
Sinus arrest | 31.26 | 10.35 | 28 | 79141 | 1419 | 29493939 |
Glomerular filtration rate decreased | 31.20 | 10.35 | 83 | 79086 | 11183 | 29484175 |
Hemiplegia | 31.07 | 10.35 | 60 | 79109 | 6534 | 29488824 |
Arteriosclerosis | 30.92 | 10.35 | 78 | 79091 | 10178 | 29485180 |
Drug dependence | 30.70 | 10.35 | 9 | 79160 | 20972 | 29474386 |
Infusion related reaction | 30.30 | 10.35 | 44 | 79125 | 43842 | 29451516 |
Disease progression | 30.13 | 10.35 | 115 | 79054 | 81801 | 29413557 |
Mitral valve incompetence | 30.05 | 10.35 | 91 | 79078 | 13202 | 29482156 |
Atrial fibrillation | 29.83 | 10.35 | 422 | 78747 | 105224 | 29390134 |
Diabetes mellitus | 29.39 | 10.35 | 195 | 78974 | 39636 | 29455722 |
N-terminal prohormone brain natriuretic peptide abnormal | 29.07 | 10.35 | 13 | 79156 | 186 | 29495172 |
Cerebral haemorrhage | 28.98 | 10.35 | 163 | 79006 | 31263 | 29464095 |
Lymphocyte count abnormal | 28.79 | 10.35 | 19 | 79150 | 608 | 29494750 |
Hyponatraemia | 28.70 | 10.35 | 292 | 78877 | 67341 | 29428017 |
Pulmonary arterial pressure abnormal | 28.63 | 10.35 | 13 | 79156 | 193 | 29495165 |
Hypotension | 28.49 | 10.35 | 701 | 78468 | 193653 | 29301705 |
Blood potassium increased | 28.29 | 10.35 | 95 | 79074 | 14556 | 29480802 |
Pancreatic neoplasm | 28.15 | 10.35 | 21 | 79148 | 820 | 29494538 |
Acute kidney injury | 27.85 | 10.35 | 917 | 78252 | 264350 | 29231008 |
Left ventricular dilatation | 27.64 | 10.35 | 19 | 79150 | 651 | 29494707 |
Clostridium difficile infection | 27.44 | 10.35 | 5 | 79164 | 16136 | 29479222 |
Conduction disorder | 27.34 | 10.35 | 29 | 79140 | 1811 | 29493547 |
Cell marker increased | 27.33 | 10.35 | 16 | 79153 | 412 | 29494946 |
Blood triglycerides increased | 27.28 | 10.35 | 86 | 79083 | 12748 | 29482610 |
Aggression | 27.22 | 10.35 | 33 | 79136 | 35508 | 29459850 |
Shock | 26.78 | 10.35 | 121 | 79048 | 21283 | 29474075 |
Pulmonary valve stenosis congenital | 26.62 | 10.35 | 11 | 79158 | 128 | 29495230 |
Oedema peripheral | 26.62 | 10.35 | 407 | 78762 | 103150 | 29392208 |
Blood uric acid increased | 26.59 | 10.35 | 52 | 79117 | 5716 | 29489642 |
Thrombocytopenia | 26.06 | 10.35 | 233 | 78936 | 134590 | 29360768 |
Painful respiration | 25.93 | 10.35 | 23 | 79146 | 1151 | 29494207 |
Blood cholesterol increased | 25.71 | 10.35 | 96 | 79073 | 15499 | 29479859 |
Gastric cancer | 25.56 | 10.35 | 46 | 79123 | 4748 | 29490610 |
Blood thyroid stimulating hormone abnormal | 25.47 | 10.35 | 13 | 79156 | 253 | 29495105 |
Suicidal ideation | 24.77 | 10.35 | 34 | 79135 | 34682 | 29460676 |
Intentional overdose | 24.34 | 10.35 | 41 | 79128 | 38487 | 29456871 |
Lung diffusion disorder | 24.12 | 10.35 | 9 | 79160 | 78 | 29495280 |
Pneumonia | 24.09 | 10.35 | 663 | 78506 | 319509 | 29175849 |
Cerebellar ischaemia | 24.08 | 10.35 | 10 | 79159 | 118 | 29495240 |
Colon cancer | 23.89 | 10.35 | 59 | 79110 | 7596 | 29487762 |
Breast discomfort | 23.70 | 10.35 | 6 | 79163 | 10 | 29495348 |
Electrocardiogram QRS complex abnormal | 23.68 | 10.35 | 13 | 79156 | 295 | 29495063 |
Urine albumin/creatinine ratio increased | 23.29 | 10.35 | 10 | 79159 | 129 | 29495229 |
Walking aid user | 23.24 | 10.35 | 24 | 79145 | 1453 | 29493905 |
Orthostatic intolerance | 23.21 | 10.35 | 17 | 79152 | 645 | 29494713 |
Intentional self-injury | 23.14 | 10.35 | 3 | 79166 | 12458 | 29482900 |
Microalbuminuria | 23.07 | 10.35 | 17 | 79152 | 651 | 29494707 |
Agitation | 23.01 | 10.35 | 66 | 79103 | 51238 | 29444120 |
Sedation | 22.80 | 10.35 | 9 | 79160 | 17396 | 29477962 |
Bradycardia | 22.64 | 10.35 | 272 | 78897 | 65357 | 29430001 |
Mucosal inflammation | 22.48 | 10.35 | 31 | 79138 | 31564 | 29463794 |
Pemphigoid | 22.17 | 10.35 | 57 | 79112 | 7524 | 29487834 |
COVID-19 | 22.13 | 10.35 | 39 | 79130 | 35975 | 29459383 |
Chronic kidney disease | 22.06 | 10.35 | 170 | 78999 | 36246 | 29459112 |
Melaena | 22.02 | 10.35 | 151 | 79018 | 31025 | 29464333 |
Atrioventricular block | 21.99 | 10.35 | 54 | 79115 | 6928 | 29488430 |
Type 2 diabetes mellitus | 21.89 | 10.35 | 83 | 79086 | 13498 | 29481860 |
Myocardial ischaemia | 21.87 | 10.35 | 93 | 79076 | 15935 | 29479423 |
Chronic pigmented purpura | 21.84 | 10.35 | 9 | 79160 | 104 | 29495254 |
Idiopathic pulmonary fibrosis | 21.70 | 10.35 | 34 | 79135 | 3134 | 29492224 |
Goitre | 21.58 | 10.35 | 23 | 79146 | 1444 | 29493914 |
Foetal exposure during pregnancy | 21.43 | 10.35 | 36 | 79133 | 33831 | 29461527 |
Hyperglycaemia | 21.29 | 10.35 | 161 | 79008 | 34126 | 29461232 |
Pancytopenia | 21.17 | 10.35 | 133 | 79036 | 83035 | 29412323 |
Subacute hepatic failure | 20.99 | 10.35 | 8 | 79161 | 74 | 29495284 |
Condition aggravated | 20.94 | 10.35 | 271 | 78898 | 146024 | 29349334 |
Renal artery stenosis | 20.85 | 10.35 | 26 | 79143 | 1935 | 29493423 |
Gastritis erosive | 20.60 | 10.35 | 45 | 79124 | 5348 | 29490010 |
Aortic valve incompetence | 20.50 | 10.35 | 43 | 79126 | 4970 | 29490388 |
Adrenal adenoma | 20.46 | 10.35 | 12 | 79157 | 310 | 29495048 |
Hyperuricaemia | 20.35 | 10.35 | 52 | 79117 | 6837 | 29488521 |
Chest injury | 20.26 | 10.35 | 22 | 79147 | 1411 | 29493947 |
Blood lactate dehydrogenase increased | 19.99 | 10.35 | 103 | 79066 | 19106 | 29476252 |
Drug resistance | 19.91 | 10.35 | 17 | 79152 | 21523 | 29473835 |
Pulmonary hypoplasia | 19.78 | 10.35 | 13 | 79156 | 413 | 29494945 |
Lateropulsion | 19.70 | 10.35 | 4 | 79165 | 0 | 29495358 |
Ventricular hypokinesia | 19.66 | 10.35 | 40 | 79129 | 4525 | 29490833 |
Vomiting | 19.63 | 10.35 | 426 | 78743 | 211834 | 29283524 |
Deep vein thrombosis | 19.57 | 10.35 | 83 | 79086 | 57316 | 29438042 |
Prostate cancer | 19.45 | 10.35 | 126 | 79043 | 25401 | 29469957 |
Sprue-like enteropathy | 19.40 | 10.35 | 13 | 79156 | 427 | 29494931 |
Gouty arthritis | 19.34 | 10.35 | 18 | 79151 | 959 | 29494399 |
Synovitis | 19.33 | 10.35 | 3 | 79166 | 10887 | 29484471 |
Patent ductus arteriosus | 19.26 | 10.35 | 32 | 79137 | 3099 | 29492259 |
Rhythm idioventricular | 19.23 | 10.35 | 11 | 79158 | 271 | 29495087 |
Dyslipidaemia | 19.22 | 10.35 | 47 | 79122 | 6014 | 29489344 |
Drug ineffective for unapproved indication | 19.21 | 10.35 | 7 | 79162 | 14207 | 29481151 |
Status epilepticus | 19.10 | 10.35 | 3 | 79166 | 10791 | 29484567 |
Drug intolerance | 19.04 | 10.35 | 66 | 79103 | 48313 | 29447045 |
Coronary arterial stent insertion | 19.03 | 10.35 | 36 | 79133 | 3861 | 29491497 |
Cardiac failure acute | 19.00 | 10.35 | 61 | 79108 | 9131 | 29486227 |
Pyonephrosis | 18.73 | 10.35 | 7 | 79162 | 61 | 29495297 |
Coronary artery restenosis | 18.65 | 10.35 | 18 | 79151 | 1004 | 29494354 |
Hypoparathyroidism | 18.52 | 10.35 | 13 | 79156 | 461 | 29494897 |
Ventricular extrasystoles | 18.16 | 10.35 | 66 | 79103 | 10516 | 29484842 |
Angioplasty | 17.98 | 10.35 | 17 | 79152 | 924 | 29494434 |
Vertigo | 17.96 | 10.35 | 110 | 79059 | 21751 | 29473607 |
Malignant neoplasm progression | 17.83 | 10.35 | 120 | 79049 | 73739 | 29421619 |
Transient ischaemic attack | 17.82 | 10.35 | 115 | 79054 | 23155 | 29472203 |
Coronary artery stenosis | 17.81 | 10.35 | 57 | 79112 | 8516 | 29486842 |
Psychotic disorder | 17.70 | 10.35 | 17 | 79152 | 20337 | 29475021 |
Lacunar infarction | 17.59 | 10.35 | 29 | 79140 | 2790 | 29492568 |
Oscillopsia | 17.44 | 10.35 | 6 | 79163 | 40 | 29495318 |
Osteoarthritis | 17.42 | 10.35 | 95 | 79074 | 18008 | 29477350 |
Pyrexia | 17.37 | 10.35 | 613 | 78556 | 287009 | 29208349 |
Neuropathy peripheral | 17.35 | 10.35 | 115 | 79054 | 70912 | 29424446 |
Hypertrophic osteoarthropathy | 17.29 | 10.35 | 7 | 79162 | 77 | 29495281 |
Brain stem infarction | 17.13 | 10.35 | 18 | 79151 | 1112 | 29494246 |
Bundle branch block right | 17.12 | 10.35 | 48 | 79121 | 6669 | 29488689 |
Quality of life decreased | 17.01 | 10.35 | 31 | 79138 | 3231 | 29492127 |
Blood pressure abnormal | 16.79 | 10.35 | 48 | 79121 | 6742 | 29488616 |
Intentional product misuse | 16.73 | 10.35 | 43 | 79126 | 34618 | 29460740 |
Urticaria chronic | 16.39 | 10.35 | 7 | 79162 | 89 | 29495269 |
Merycism | 16.29 | 10.35 | 6 | 79163 | 50 | 29495308 |
Retinopathy | 16.28 | 10.35 | 22 | 79147 | 1773 | 29493585 |
Nephrogenic anaemia | 16.02 | 10.35 | 23 | 79146 | 1962 | 29493396 |
Liver function test increased | 15.81 | 10.35 | 6 | 79163 | 11879 | 29483479 |
Chest pain | 15.81 | 10.35 | 402 | 78767 | 111571 | 29383787 |
Leukopenia | 15.79 | 10.35 | 85 | 79084 | 55118 | 29440240 |
Periarthritis calcarea | 15.79 | 10.35 | 6 | 79163 | 55 | 29495303 |
Cardiac vein perforation | 15.74 | 10.35 | 5 | 79164 | 25 | 29495333 |
Peripheral arterial occlusive disease | 15.71 | 10.35 | 39 | 79130 | 5037 | 29490321 |
Surfactant protein increased | 15.68 | 10.35 | 4 | 79165 | 7 | 29495351 |
Articular calcification | 15.51 | 10.35 | 6 | 79163 | 58 | 29495300 |
Neurotoxicity | 15.48 | 10.35 | 10 | 79159 | 14603 | 29480755 |
Bile duct cancer | 15.47 | 10.35 | 13 | 79156 | 604 | 29494754 |
Pericardial haemorrhage | 15.47 | 10.35 | 28 | 79141 | 2903 | 29492455 |
Disease recurrence | 15.40 | 10.35 | 12 | 79157 | 15902 | 29479456 |
Diabetic nephropathy | 15.35 | 10.35 | 22 | 79147 | 1873 | 29493485 |
Blood pressure systolic increased | 15.28 | 10.35 | 87 | 79082 | 16758 | 29478600 |
Erectile dysfunction | 15.03 | 10.35 | 91 | 79078 | 17918 | 29477440 |
Seizure | 15.03 | 10.35 | 168 | 79001 | 92955 | 29402403 |
Myelosuppression | 14.94 | 10.35 | 7 | 79162 | 12220 | 29483138 |
Septic shock | 14.92 | 10.35 | 102 | 79067 | 62458 | 29432900 |
Cardiac pacemaker insertion | 14.80 | 10.35 | 25 | 79144 | 2454 | 29492904 |
Angina unstable | 14.79 | 10.35 | 63 | 79106 | 10802 | 29484556 |
Blepharochalasis | 14.78 | 10.35 | 3 | 79166 | 0 | 29495358 |
Renal dysplasia | 14.75 | 10.35 | 8 | 79161 | 177 | 29495181 |
Acquired C1 inhibitor deficiency | 14.72 | 10.35 | 4 | 79165 | 10 | 29495348 |
Loss of consciousness | 14.62 | 10.35 | 279 | 78890 | 73777 | 29421581 |
Dyspnoea | 14.56 | 10.35 | 1038 | 78131 | 325694 | 29169664 |
Atrial thrombosis | 14.51 | 10.35 | 22 | 79147 | 1971 | 29493387 |
Myoglobin blood increased | 14.49 | 10.35 | 22 | 79147 | 1973 | 29493385 |
Fear | 14.43 | 10.35 | 57 | 79112 | 9447 | 29485911 |
Generalised tonic-clonic seizure | 14.41 | 10.35 | 18 | 79151 | 19121 | 29476237 |
Cytomegalovirus infection | 14.39 | 10.35 | 25 | 79144 | 23190 | 29472168 |
Abnormal behaviour | 14.25 | 10.35 | 25 | 79144 | 23102 | 29472256 |
Ischaemic stroke | 14.15 | 10.35 | 82 | 79087 | 15895 | 29479463 |
Nausea | 14.09 | 10.35 | 632 | 78537 | 288623 | 29206735 |
Immature granulocyte count increased | 14.00 | 10.35 | 6 | 79163 | 77 | 29495281 |
Rheumatoid arthritis | 13.95 | 10.35 | 42 | 79127 | 32110 | 29463248 |
Product substitution issue | 13.92 | 10.35 | 55 | 79114 | 9117 | 29486241 |
Chest discomfort | 13.90 | 10.35 | 186 | 78983 | 45797 | 29449561 |
Glycosylated haemoglobin increased | 13.88 | 10.35 | 56 | 79113 | 9370 | 29485988 |
Abdominal tenderness | 13.81 | 10.35 | 30 | 79139 | 3552 | 29491806 |
Bursitis | 13.79 | 10.35 | 36 | 79133 | 4796 | 29490562 |
Serotonin syndrome | 13.69 | 10.35 | 16 | 79153 | 17496 | 29477862 |
Adrenal cyst | 13.66 | 10.35 | 6 | 79163 | 82 | 29495276 |
Hypertensive heart disease | 13.59 | 10.35 | 22 | 79147 | 2085 | 29493273 |
Diabetic retinopathy | 13.57 | 10.35 | 19 | 79150 | 1583 | 29493775 |
Carotid artery stenosis | 13.48 | 10.35 | 34 | 79135 | 4435 | 29490923 |
Malabsorption | 13.47 | 10.35 | 21 | 79148 | 1927 | 29493431 |
Colitis | 13.43 | 10.35 | 41 | 79128 | 31207 | 29464151 |
Therapeutic product effect incomplete | 13.29 | 10.35 | 57 | 79112 | 39248 | 29456110 |
Small intestine carcinoma | 13.28 | 10.35 | 11 | 79158 | 501 | 29494857 |
Chest wall haematoma | 13.28 | 10.35 | 7 | 79162 | 146 | 29495212 |
Lipid metabolism disorder | 13.18 | 10.35 | 9 | 79160 | 305 | 29495053 |
Eyelid ptosis congenital | 13.10 | 10.35 | 6 | 79163 | 91 | 29495267 |
Rales | 13.02 | 10.35 | 47 | 79122 | 7463 | 29487895 |
Ejection fraction decreased | 12.87 | 10.35 | 80 | 79089 | 15898 | 29479460 |
Dystonia | 12.84 | 10.35 | 5 | 79164 | 9744 | 29485614 |
Legionella test positive | 12.71 | 10.35 | 3 | 79166 | 3 | 29495355 |
Constipation | 12.69 | 10.35 | 222 | 78947 | 113938 | 29381420 |
Bacteraemia | 12.66 | 10.35 | 15 | 79154 | 16308 | 29479050 |
Hypocapnia | 12.63 | 10.35 | 7 | 79162 | 162 | 29495196 |
Ejection fraction abnormal | 12.61 | 10.35 | 13 | 79156 | 785 | 29494573 |
Graft versus host disease | 12.58 | 10.35 | 5 | 79164 | 9623 | 29485735 |
Atrioventricular block first degree | 12.58 | 10.35 | 37 | 79132 | 5282 | 29490076 |
Malignant melanoma | 12.57 | 10.35 | 45 | 79124 | 7116 | 29488242 |
Coronary artery occlusion | 12.57 | 10.35 | 57 | 79112 | 10037 | 29485321 |
Tricuspid valve incompetence | 12.47 | 10.35 | 50 | 79119 | 8344 | 29487014 |
Neutropenic sepsis | 12.46 | 10.35 | 8 | 79161 | 11719 | 29483639 |
Hepatic calcification | 12.44 | 10.35 | 9 | 79160 | 335 | 29495023 |
Costal cartilage fracture | 12.43 | 10.35 | 8 | 79161 | 245 | 29495113 |
Cholangiocarcinoma | 12.42 | 10.35 | 14 | 79155 | 936 | 29494422 |
Protein urine present | 12.41 | 10.35 | 34 | 79135 | 4660 | 29490698 |
Renal cell carcinoma | 12.40 | 10.35 | 34 | 79135 | 4662 | 29490696 |
Blood pressure systolic decreased | 12.39 | 10.35 | 30 | 79139 | 3814 | 29491544 |
Pulmonary embolism | 12.37 | 10.35 | 138 | 79031 | 76396 | 29418962 |
Tachycardia | 12.33 | 10.35 | 129 | 79040 | 72281 | 29423077 |
Cardiovascular disorder | 12.31 | 10.35 | 52 | 79117 | 8883 | 29486475 |
Erythema multiforme | 12.30 | 10.35 | 47 | 79122 | 7670 | 29487688 |
Therapy non-responder | 12.28 | 10.35 | 42 | 79127 | 30869 | 29464489 |
Extrasystoles | 12.16 | 10.35 | 28 | 79141 | 3446 | 29491912 |
Adrenomegaly | 12.14 | 10.35 | 9 | 79160 | 348 | 29495010 |
Atrioventricular block complete | 12.12 | 10.35 | 48 | 79121 | 7963 | 29487395 |
Respiratory depression | 12.10 | 10.35 | 11 | 79158 | 13512 | 29481846 |
Abdominal compartment syndrome | 12.07 | 10.35 | 13 | 79156 | 826 | 29494532 |
Palpitations | 12.06 | 10.35 | 137 | 79032 | 32467 | 29462891 |
Extrapyramidal disorder | 12.05 | 10.35 | 7 | 79162 | 10824 | 29484534 |
Oedema neonatal | 11.98 | 10.35 | 4 | 79165 | 24 | 29495334 |
Thrombotic stroke | 11.98 | 10.35 | 8 | 79161 | 261 | 29495097 |
Lower respiratory tract infection | 11.95 | 10.35 | 34 | 79135 | 26468 | 29468890 |
Loss of personal independence in daily activities | 11.94 | 10.35 | 32 | 79137 | 25408 | 29469950 |
Choroidal detachment | 11.92 | 10.35 | 9 | 79160 | 358 | 29495000 |
Malaise | 11.76 | 10.35 | 531 | 78638 | 159071 | 29336287 |
Primary hyperaldosteronism | 11.75 | 10.35 | 5 | 79164 | 63 | 29495295 |
Osteitis deformans | 11.71 | 10.35 | 4 | 79165 | 26 | 29495332 |
Hepatic cancer | 11.71 | 10.35 | 41 | 79128 | 6415 | 29488943 |
Nodal rhythm | 11.70 | 10.35 | 16 | 79153 | 1304 | 29494054 |
Influenza | 11.69 | 10.35 | 65 | 79104 | 41816 | 29453542 |
Electrocardiogram ST segment depression | 11.69 | 10.35 | 21 | 79148 | 2164 | 29493194 |
Coronary angioplasty | 11.68 | 10.35 | 9 | 79160 | 369 | 29494989 |
Genital candidiasis | 11.68 | 10.35 | 5 | 79164 | 64 | 29495294 |
Dyspnoea exertional | 11.61 | 10.35 | 149 | 79020 | 36341 | 29459017 |
Dyslalia | 11.59 | 10.35 | 10 | 79159 | 482 | 29494876 |
Metamyelocyte count increased | 11.51 | 10.35 | 9 | 79160 | 377 | 29494981 |
Pancreatitis chronic | 11.51 | 10.35 | 20 | 79149 | 2008 | 29493350 |
Miscarriage of partner | 11.50 | 10.35 | 3 | 79166 | 6 | 29495352 |
Lymphocyte count | 11.47 | 10.35 | 5 | 79164 | 67 | 29495291 |
Ventricular hypertrophy | 11.39 | 10.35 | 31 | 79138 | 4233 | 29491125 |
Neuromyopathy | 11.34 | 10.35 | 13 | 79156 | 886 | 29494472 |
pH body fluid increased | 11.28 | 10.35 | 5 | 79164 | 70 | 29495288 |
Ischaemic cardiomyopathy | 11.27 | 10.35 | 37 | 79132 | 5601 | 29489757 |
Plasma cell myeloma | 11.26 | 10.35 | 56 | 79113 | 37059 | 29458299 |
Hallucination | 11.11 | 10.35 | 72 | 79097 | 44640 | 29450718 |
Carcinoid tumour | 11.06 | 10.35 | 7 | 79162 | 208 | 29495150 |
Bladder cancer | 11.02 | 10.35 | 55 | 79114 | 10072 | 29485286 |
Cardiac valve sclerosis | 10.97 | 10.35 | 5 | 79164 | 75 | 29495283 |
Renal cyst | 10.88 | 10.35 | 46 | 79123 | 7861 | 29487497 |
Emotional distress | 10.84 | 10.35 | 69 | 79100 | 13826 | 29481532 |
Feeling cold | 10.78 | 10.35 | 51 | 79118 | 9140 | 29486218 |
Small intestinal haemorrhage | 10.78 | 10.35 | 19 | 79150 | 1930 | 29493428 |
Candida infection | 10.77 | 10.35 | 15 | 79154 | 15210 | 29480148 |
Acute coronary syndrome | 10.75 | 10.35 | 63 | 79106 | 12262 | 29483096 |
Hepatitis E antibody positive | 10.74 | 10.35 | 6 | 79163 | 141 | 29495217 |
Renal failure neonatal | 10.73 | 10.35 | 5 | 79164 | 79 | 29495279 |
Hepatic function abnormal | 10.73 | 10.35 | 156 | 79013 | 39103 | 29456255 |
Joint stiffness | 10.71 | 10.35 | 6 | 79163 | 9467 | 29485891 |
Adverse drug reaction | 10.69 | 10.35 | 31 | 79138 | 23989 | 29471369 |
Bronchitis | 10.68 | 10.35 | 148 | 79021 | 36720 | 29458638 |
Aortic aneurysm rupture | 10.68 | 10.35 | 13 | 79156 | 944 | 29494414 |
Hypercholesterolaemia | 10.66 | 10.35 | 43 | 79126 | 7195 | 29488163 |
Hypocalvaria | 10.64 | 10.35 | 3 | 79166 | 9 | 29495349 |
Product residue present | 10.64 | 10.35 | 22 | 79147 | 2517 | 29492841 |
Post streptococcal glomerulonephritis | 10.59 | 10.35 | 4 | 79165 | 36 | 29495322 |
Concomitant disease progression | 10.54 | 10.35 | 21 | 79148 | 2340 | 29493018 |
Aneurysm | 10.45 | 10.35 | 17 | 79152 | 1617 | 29493741 |
Blood zinc decreased | 10.41 | 10.35 | 3 | 79166 | 10 | 29495348 |
Injection site pain | 10.40 | 10.35 | 48 | 79121 | 32398 | 29462960 |
Eczema | 10.38 | 10.35 | 68 | 79101 | 13758 | 29481600 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Blood pressure inadequately controlled | 304.52 | 9.76 | 175 | 144955 | 5209 | 64348393 |
Off label use | 287.31 | 9.76 | 624 | 144506 | 632182 | 63721420 |
Blood pressure increased | 232.45 | 9.76 | 884 | 144246 | 171668 | 64181934 |
Completed suicide | 230.93 | 9.76 | 108 | 145022 | 224306 | 64129296 |
Hyperkalaemia | 225.53 | 9.76 | 616 | 144514 | 100513 | 64253089 |
Cardiac failure congestive | 221.57 | 9.76 | 722 | 144408 | 129858 | 64223744 |
Myocardial infarction | 213.91 | 9.76 | 838 | 144292 | 164983 | 64188619 |
Hyponatraemia | 201.42 | 9.76 | 762 | 144368 | 147577 | 64206025 |
Cerebral infarction | 176.45 | 9.76 | 325 | 144805 | 40719 | 64312883 |
Drug abuse | 164.29 | 9.76 | 47 | 145083 | 132327 | 64221275 |
Toxicity to various agents | 156.72 | 9.76 | 368 | 144762 | 363145 | 63990457 |
Coronary artery disease | 153.96 | 9.76 | 387 | 144743 | 60046 | 64293556 |
Drug ineffective | 141.79 | 9.76 | 1211 | 143919 | 839036 | 63514566 |
Hypertensive crisis | 139.16 | 9.76 | 188 | 144942 | 18060 | 64335542 |
Acute kidney injury | 135.41 | 9.76 | 1575 | 143555 | 447665 | 63905937 |
Blood creatinine increased | 128.20 | 9.76 | 625 | 144505 | 135157 | 64218445 |
Renal failure | 128.04 | 9.76 | 772 | 144358 | 180916 | 64172686 |
Death | 127.93 | 9.76 | 605 | 144525 | 482100 | 63871502 |
Syncope | 117.63 | 9.76 | 680 | 144450 | 156955 | 64196647 |
Hand deformity | 116.35 | 9.76 | 6 | 145124 | 62765 | 64290837 |
Oedema peripheral | 106.63 | 9.76 | 824 | 144306 | 209493 | 64144109 |
Febrile neutropenia | 104.33 | 9.76 | 163 | 144967 | 187494 | 64166108 |
Infusion related reaction | 103.23 | 9.76 | 131 | 144999 | 164336 | 64189266 |
Dizziness | 95.98 | 9.76 | 1428 | 143702 | 428735 | 63924867 |
Systemic lupus erythematosus | 95.46 | 9.76 | 28 | 145102 | 77584 | 64276018 |
Product use in unapproved indication | 94.80 | 9.76 | 157 | 144973 | 176461 | 64177141 |
Cardiac failure | 92.27 | 9.76 | 561 | 144569 | 131812 | 64221790 |
Product use issue | 91.97 | 9.76 | 124 | 145006 | 151591 | 64202011 |
Glossodynia | 90.00 | 9.76 | 18 | 145112 | 64678 | 64288924 |
Pemphigus | 84.21 | 9.76 | 17 | 145113 | 60684 | 64292918 |
Atrial fibrillation | 83.74 | 9.76 | 665 | 144465 | 170424 | 64183178 |
Acute myocardial infarction | 83.10 | 9.76 | 344 | 144786 | 69374 | 64284228 |
Blood urea increased | 82.92 | 9.76 | 253 | 144877 | 43900 | 64309702 |
Hypotension | 82.32 | 9.76 | 1258 | 143872 | 379716 | 63973886 |
Cerebrovascular accident | 82.32 | 9.76 | 561 | 144569 | 137022 | 64216580 |
Colitis microscopic | 79.90 | 9.76 | 91 | 145039 | 7341 | 64346261 |
Angina pectoris | 78.83 | 9.76 | 252 | 144878 | 44829 | 64308773 |
Renal impairment | 78.09 | 9.76 | 546 | 144584 | 134471 | 64219131 |
Blood glucose increased | 75.68 | 9.76 | 427 | 144703 | 97646 | 64255956 |
Alopecia | 74.29 | 9.76 | 164 | 144966 | 165526 | 64188076 |
Pericarditis | 72.53 | 9.76 | 25 | 145105 | 62491 | 64291111 |
Oligohydramnios | 69.34 | 9.76 | 57 | 145073 | 3067 | 64350535 |
Mitral valve incompetence | 66.54 | 9.76 | 165 | 144965 | 25373 | 64328229 |
Neutropenia | 66.48 | 9.76 | 295 | 144835 | 239329 | 64114273 |
Angioedema | 65.95 | 9.76 | 295 | 144835 | 61526 | 64292076 |
Joint swelling | 63.53 | 9.76 | 259 | 144871 | 215123 | 64138479 |
Treatment failure | 62.51 | 9.76 | 104 | 145026 | 116712 | 64236890 |
Condition aggravated | 62.34 | 9.76 | 537 | 144593 | 371889 | 63981713 |
Arthropathy | 61.72 | 9.76 | 111 | 145019 | 120856 | 64232746 |
Bundle branch block left | 61.25 | 9.76 | 93 | 145037 | 9941 | 64343661 |
Maternal exposure during pregnancy | 60.52 | 9.76 | 76 | 145054 | 95808 | 64257794 |
Cardiac failure chronic | 58.34 | 9.76 | 86 | 145044 | 8955 | 64344647 |
Bronchial neoplasm | 56.55 | 9.76 | 25 | 145105 | 418 | 64353184 |
Duodenal ulcer perforation | 56.55 | 9.76 | 6 | 145124 | 34619 | 64318983 |
Intentional product use issue | 54.73 | 9.76 | 81 | 145049 | 95283 | 64258319 |
Nasal turbinate hypertrophy | 53.31 | 9.76 | 26 | 145104 | 549 | 64353053 |
Wound | 53.26 | 9.76 | 56 | 145074 | 76421 | 64277181 |
Bradycardia | 53.23 | 9.76 | 451 | 144679 | 117768 | 64235834 |
Interstitial lung disease | 52.88 | 9.76 | 389 | 144741 | 97343 | 64256259 |
Pain | 52.52 | 9.76 | 903 | 144227 | 552608 | 63800994 |
Labile hypertension | 52.09 | 9.76 | 25 | 145105 | 509 | 64353093 |
Therapeutic product effect decreased | 51.83 | 9.76 | 114 | 145016 | 115237 | 64238365 |
Product dose omission issue | 51.47 | 9.76 | 244 | 144886 | 194503 | 64159099 |
Blood creatine phosphokinase increased | 51.29 | 9.76 | 264 | 144866 | 58294 | 64295308 |
Product prescribing error | 50.98 | 9.76 | 185 | 144945 | 35084 | 64318518 |
Intentional overdose | 50.07 | 9.76 | 78 | 145052 | 89866 | 64263736 |
Product impurity | 49.29 | 9.76 | 15 | 145115 | 78 | 64353524 |
Drug intolerance | 47.67 | 9.76 | 239 | 144891 | 187753 | 64165849 |
Anaemia | 46.90 | 9.76 | 1149 | 143981 | 377531 | 63976071 |
Glaucoma | 46.21 | 9.76 | 109 | 145021 | 16239 | 64337363 |
Exposure during pregnancy | 45.53 | 9.76 | 65 | 145065 | 77610 | 64275992 |
Total lung capacity increased | 45.43 | 9.76 | 25 | 145105 | 683 | 64352919 |
Angina unstable | 44.67 | 9.76 | 104 | 145026 | 15363 | 64338239 |
Diabetes mellitus inadequate control | 44.63 | 9.76 | 127 | 145003 | 21194 | 64332408 |
Rheumatoid arthritis | 44.49 | 9.76 | 204 | 144926 | 164090 | 64189512 |
Chest pain | 44.41 | 9.76 | 762 | 144368 | 235218 | 64118384 |
Sleep disorder due to general medical condition, insomnia type | 44.35 | 9.76 | 4 | 145126 | 26266 | 64327336 |
Melaena | 43.19 | 9.76 | 236 | 144894 | 53312 | 64300290 |
Endometrial ablation | 42.55 | 9.76 | 25 | 145105 | 776 | 64352826 |
Sinus arrest | 42.31 | 9.76 | 43 | 145087 | 3047 | 64350555 |
Thyroid disorder | 42.18 | 9.76 | 86 | 145044 | 11606 | 64341996 |
Contraindicated product administered | 41.83 | 9.76 | 115 | 145015 | 107714 | 64245888 |
Blood pressure decreased | 41.55 | 9.76 | 334 | 144796 | 85865 | 64267737 |
Synovitis | 41.25 | 9.76 | 102 | 145028 | 98988 | 64254614 |
Hospitalisation | 41.12 | 9.76 | 66 | 145064 | 75141 | 64278461 |
Blood lactate dehydrogenase increased | 40.81 | 9.76 | 165 | 144965 | 32913 | 64320689 |
Transient ischaemic attack | 40.66 | 9.76 | 202 | 144928 | 43980 | 64309622 |
Helicobacter infection | 40.12 | 9.76 | 18 | 145112 | 38344 | 64315258 |
Chronic kidney disease | 40.02 | 9.76 | 245 | 144885 | 57674 | 64295928 |
Obstructive airways disorder | 39.07 | 9.76 | 128 | 145002 | 23057 | 64330545 |
Arteriosclerosis | 38.67 | 9.76 | 100 | 145030 | 15777 | 64337825 |
Folliculitis | 38.57 | 9.76 | 10 | 145120 | 30067 | 64323535 |
Infection | 38.28 | 9.76 | 251 | 144879 | 184629 | 64168973 |
Coronary arterial stent insertion | 37.97 | 9.76 | 55 | 145075 | 5637 | 64347965 |
Gamma-glutamyltransferase increased | 37.92 | 9.76 | 212 | 144918 | 48298 | 64305304 |
Asthenia | 37.48 | 9.76 | 1243 | 143887 | 426801 | 63926801 |
Bronchial haemorrhage | 37.43 | 9.76 | 27 | 145103 | 1195 | 64352407 |
Blood lactic acid | 37.21 | 9.76 | 19 | 145111 | 444 | 64353158 |
Forced expiratory volume decreased | 36.86 | 9.76 | 60 | 145070 | 6807 | 64346795 |
Disease progression | 36.55 | 9.76 | 179 | 144951 | 141501 | 64212101 |
Blood potassium increased | 36.47 | 9.76 | 135 | 144995 | 25845 | 64327757 |
Tricuspid valve incompetence | 36.29 | 9.76 | 102 | 145028 | 16901 | 64336701 |
Swelling | 36.03 | 9.76 | 212 | 144918 | 160006 | 64193596 |
Ischaemic stroke | 35.96 | 9.76 | 145 | 144985 | 28890 | 64324712 |
Foetal disorder | 35.95 | 9.76 | 13 | 145117 | 124 | 64353478 |
Rash | 35.80 | 9.76 | 773 | 144357 | 457776 | 63895826 |
Diverticulitis | 35.14 | 9.76 | 176 | 144954 | 38442 | 64315160 |
Cerebral haemorrhage | 34.60 | 9.76 | 215 | 144915 | 50875 | 64302727 |
N-terminal prohormone brain natriuretic peptide abnormal | 34.59 | 9.76 | 15 | 145115 | 239 | 64353363 |
Myocardial ischaemia | 34.48 | 9.76 | 123 | 145007 | 23128 | 64330474 |
Injection site pain | 34.07 | 9.76 | 132 | 144998 | 111276 | 64242326 |
Cardiac failure acute | 33.87 | 9.76 | 97 | 145033 | 16247 | 64337355 |
Aortic aneurysm | 33.83 | 9.76 | 61 | 145069 | 7513 | 64346089 |
Arrhythmia | 33.50 | 9.76 | 219 | 144911 | 52725 | 64300877 |
Diverticulum intestinal | 33.45 | 9.76 | 60 | 145070 | 7360 | 64346242 |
Lymphatic fistula | 33.43 | 9.76 | 21 | 145109 | 737 | 64352865 |
Femoral hernia incarcerated | 33.35 | 9.76 | 21 | 145109 | 740 | 64352862 |
Drug hypersensitivity | 33.33 | 9.76 | 358 | 144772 | 237457 | 64116145 |
Suicidal ideation | 33.09 | 9.76 | 62 | 145068 | 66480 | 64287122 |
Abortion spontaneous | 32.93 | 9.76 | 8 | 145122 | 25135 | 64328467 |
Drug resistance | 32.93 | 9.76 | 19 | 145111 | 35083 | 64318519 |
Fear of disease | 32.40 | 9.76 | 22 | 145108 | 883 | 64352719 |
Psoriatic arthropathy | 32.08 | 9.76 | 30 | 145100 | 43251 | 64310351 |
Intentional product misuse | 32.02 | 9.76 | 72 | 145058 | 72223 | 64281379 |
Arthralgia | 31.84 | 9.76 | 755 | 144375 | 441505 | 63912097 |
Hyperglycaemia | 31.46 | 9.76 | 240 | 144890 | 60728 | 64292874 |
Atrioventricular block complete | 31.27 | 9.76 | 87 | 145043 | 14331 | 64339271 |
COVID-19 | 31.25 | 9.76 | 62 | 145068 | 65078 | 64288524 |
Rheumatoid factor positive | 31.25 | 9.76 | 20 | 145110 | 34918 | 64318684 |
Dyspnoea | 31.02 | 9.76 | 1942 | 143188 | 716732 | 63636870 |
Eosinophilic colitis | 30.83 | 9.76 | 16 | 145114 | 387 | 64353215 |
Cardiovascular disorder | 30.75 | 9.76 | 92 | 145038 | 15789 | 64337813 |
Lymphocyte stimulation test positive | 30.64 | 9.76 | 23 | 145107 | 1083 | 64352519 |
Rhabdomyolysis | 30.38 | 9.76 | 328 | 144802 | 91398 | 64262204 |
Pancreatic steatosis | 30.26 | 9.76 | 22 | 145108 | 986 | 64352616 |
Pancreatic neoplasm | 30.02 | 9.76 | 25 | 145105 | 1370 | 64352232 |
Bronchial disorder | 30.00 | 9.76 | 30 | 145100 | 2085 | 64351517 |
Dehydration | 29.94 | 9.76 | 668 | 144462 | 216095 | 64137507 |
Thrombotic stroke | 29.86 | 9.76 | 19 | 145111 | 682 | 64352920 |
Hemiplegia | 29.65 | 9.76 | 79 | 145051 | 12689 | 64340913 |
Coronary artery stenosis | 29.65 | 9.76 | 73 | 145057 | 11175 | 64342427 |
Vascular resistance pulmonary decreased | 29.64 | 9.76 | 10 | 145120 | 76 | 64353526 |
Diabetic retinopathy | 29.24 | 9.76 | 34 | 145096 | 2805 | 64350797 |
Pemphigoid | 28.80 | 9.76 | 79 | 145051 | 12907 | 64340695 |
Liver function test increased | 28.71 | 9.76 | 17 | 145113 | 30953 | 64322649 |
Bronchitis | 28.58 | 9.76 | 372 | 144758 | 108371 | 64245231 |
Atrioventricular block | 28.57 | 9.76 | 75 | 145055 | 11940 | 64341662 |
Rhonchi | 28.43 | 9.76 | 37 | 145093 | 3426 | 64350176 |
Hypertension | 28.35 | 9.76 | 774 | 144356 | 258487 | 64095115 |
Cardiomegaly | 28.31 | 9.76 | 117 | 145013 | 23567 | 64330035 |
Muscle injury | 28.28 | 9.76 | 12 | 145118 | 26425 | 64327177 |
Blood uric acid increased | 28.22 | 9.76 | 59 | 145071 | 8104 | 64345498 |
Status epilepticus | 28.17 | 9.76 | 7 | 145123 | 21656 | 64331946 |
Fall | 28.14 | 9.76 | 1176 | 143954 | 415650 | 63937952 |
Renal artery stenosis | 28.01 | 9.76 | 34 | 145096 | 2935 | 64350667 |
Haematoma | 27.87 | 9.76 | 189 | 144941 | 46061 | 64307541 |
Oxygen saturation increased | 27.51 | 9.76 | 16 | 145114 | 487 | 64353115 |
Coronary artery occlusion | 27.40 | 9.76 | 81 | 145049 | 13810 | 64339792 |
Stomatitis | 27.39 | 9.76 | 140 | 144990 | 109465 | 64244137 |
Coronary artery restenosis | 27.33 | 9.76 | 23 | 145107 | 1279 | 64352323 |
Discomfort | 27.26 | 9.76 | 92 | 145038 | 80786 | 64272816 |
Device dislocation | 27.23 | 9.76 | 7 | 145123 | 21171 | 64332431 |
Left ventricular dilatation | 27.20 | 9.76 | 20 | 145110 | 912 | 64352690 |
Left-to-right cardiac shunt | 27.06 | 9.76 | 10 | 145120 | 102 | 64353500 |
Disease recurrence | 26.89 | 9.76 | 19 | 145111 | 31491 | 64322111 |
Ischaemic cardiomyopathy | 26.72 | 9.76 | 52 | 145078 | 6786 | 64346816 |
Pregnancy | 26.63 | 9.76 | 7 | 145123 | 20858 | 64332744 |
Renal cyst | 26.43 | 9.76 | 75 | 145055 | 12495 | 64341107 |
Hypoglycaemia | 26.41 | 9.76 | 314 | 144816 | 89578 | 64264024 |
Cell marker increased | 26.36 | 9.76 | 17 | 145113 | 625 | 64352977 |
Drug ineffective for unapproved indication | 26.27 | 9.76 | 19 | 145111 | 31114 | 64322488 |
Tachyarrhythmia | 26.24 | 9.76 | 48 | 145082 | 5978 | 64347624 |
Sedation | 26.01 | 9.76 | 33 | 145097 | 41429 | 64312173 |
Diabetes mellitus | 26.00 | 9.76 | 246 | 144884 | 66228 | 64287374 |
Hip arthroplasty | 25.71 | 9.76 | 8 | 145122 | 21343 | 64332259 |
Blood pressure systolic increased | 25.69 | 9.76 | 195 | 144935 | 49258 | 64304344 |
Psychotic disorder | 25.59 | 9.76 | 24 | 145106 | 34554 | 64319048 |
Intentional self-injury | 25.47 | 9.76 | 17 | 145113 | 29027 | 64324575 |
Injection site reaction | 25.46 | 9.76 | 41 | 145089 | 46623 | 64306979 |
Dyslipidaemia | 25.45 | 9.76 | 61 | 145069 | 9181 | 64344421 |
Blister | 25.35 | 9.76 | 95 | 145035 | 80872 | 64272730 |
Brain natriuretic peptide abnormal | 25.24 | 9.76 | 17 | 145113 | 673 | 64352929 |
Myelosuppression | 25.20 | 9.76 | 11 | 145119 | 23819 | 64329783 |
Blood sodium decreased | 25.17 | 9.76 | 132 | 144998 | 29350 | 64324252 |
Arterial haemorrhage | 25.15 | 9.76 | 28 | 145102 | 2203 | 64351399 |
Cytomegalovirus infection | 25.05 | 9.76 | 28 | 145102 | 37171 | 64316431 |
Drug dependence | 24.79 | 9.76 | 23 | 145107 | 33289 | 64320313 |
Ventricular hypertrophy | 24.79 | 9.76 | 49 | 145081 | 6467 | 64347135 |
Lower respiratory tract infection | 24.71 | 9.76 | 119 | 145011 | 94495 | 64259107 |
Clostridium difficile infection | 24.60 | 9.76 | 27 | 145103 | 36136 | 64317466 |
Brain stem stroke | 24.47 | 9.76 | 14 | 145116 | 413 | 64353189 |
Idiopathic pulmonary fibrosis | 24.30 | 9.76 | 36 | 145094 | 3764 | 64349838 |
Haematochezia | 24.18 | 9.76 | 242 | 144888 | 66131 | 64287471 |
Wound infection pseudomonas | 24.09 | 9.76 | 23 | 145107 | 1510 | 64352092 |
Lacunar infarction | 24.01 | 9.76 | 44 | 145086 | 5488 | 64348114 |
Colon cancer | 23.91 | 9.76 | 73 | 145057 | 12666 | 64340936 |
Gastric cancer | 23.71 | 9.76 | 48 | 145082 | 6445 | 64347157 |
Coronary angioplasty | 23.66 | 9.76 | 13 | 145117 | 354 | 64353248 |
Sinusitis | 23.65 | 9.76 | 212 | 144918 | 145716 | 64207886 |
Glomerular filtration rate decreased | 23.64 | 9.76 | 97 | 145033 | 19475 | 64334127 |
Hyperuricaemia | 23.61 | 9.76 | 63 | 145067 | 10128 | 64343474 |
Hypokalaemia | 23.39 | 9.76 | 395 | 144735 | 121508 | 64232094 |
Orthostatic intolerance | 23.26 | 9.76 | 23 | 145107 | 1577 | 64352025 |
Hepatic function abnormal | 23.19 | 9.76 | 234 | 144896 | 64079 | 64289523 |
Musculoskeletal stiffness | 23.16 | 9.76 | 172 | 144958 | 123034 | 64230568 |
Pyrexia | 23.05 | 9.76 | 1025 | 144105 | 557619 | 63795983 |
Ventricular extrasystoles | 22.88 | 9.76 | 89 | 145041 | 17440 | 64336162 |
Lung diffusion disorder | 22.76 | 9.76 | 9 | 145121 | 112 | 64353490 |
Monoplegia | 22.57 | 9.76 | 33 | 145097 | 3410 | 64350192 |
Nodal rhythm | 22.50 | 9.76 | 30 | 145100 | 2844 | 64350758 |
Shock | 22.29 | 9.76 | 155 | 144975 | 38085 | 64315517 |
Chronic pigmented purpura | 22.21 | 9.76 | 10 | 145120 | 175 | 64353427 |
Hypochromic anaemia | 22.15 | 9.76 | 27 | 145103 | 2341 | 64351261 |
Renal cell carcinoma | 22.14 | 9.76 | 45 | 145085 | 6059 | 64347543 |
Adverse drug reaction | 22.04 | 9.76 | 43 | 145087 | 45421 | 64308181 |
Eructation | 21.47 | 9.76 | 57 | 145073 | 9134 | 64344468 |
Hypertensive heart disease | 21.46 | 9.76 | 34 | 145096 | 3770 | 64349832 |
Septic shock | 21.38 | 9.76 | 144 | 144986 | 105293 | 64248309 |
Electrocardiogram QRS complex abnormal | 21.11 | 9.76 | 14 | 145116 | 540 | 64353062 |
Graft versus host disease | 21.07 | 9.76 | 3 | 145127 | 13810 | 64339792 |
Bone marrow failure | 21.03 | 9.76 | 48 | 145082 | 47904 | 64305698 |
Blood aldosterone increased | 20.64 | 9.76 | 10 | 145120 | 208 | 64353394 |
Adrenomegaly | 20.58 | 9.76 | 12 | 145118 | 367 | 64353235 |
Gastrointestinal disorder | 20.53 | 9.76 | 118 | 145012 | 89591 | 64264011 |
Lateropulsion | 20.40 | 9.76 | 4 | 145126 | 0 | 64353602 |
Bundle branch block right | 20.37 | 9.76 | 60 | 145070 | 10209 | 64343393 |
Device issue | 20.21 | 9.76 | 13 | 145117 | 22635 | 64330967 |
Respiratory arrest | 20.17 | 9.76 | 57 | 145073 | 52928 | 64300674 |
Inguinal hernia | 20.07 | 9.76 | 41 | 145089 | 5540 | 64348062 |
General physical health deterioration | 20.03 | 9.76 | 602 | 144528 | 203823 | 64149779 |
Therapy interrupted | 20.03 | 9.76 | 10 | 145120 | 20026 | 64333576 |
Prostate cancer | 20.02 | 9.76 | 93 | 145037 | 19702 | 64333900 |
Vertigo | 19.99 | 9.76 | 212 | 144918 | 58799 | 64294803 |
Chest injury | 19.98 | 9.76 | 26 | 145104 | 2407 | 64351195 |
Migraine | 19.98 | 9.76 | 73 | 145057 | 62604 | 64290998 |
Retrograde amnesia | 19.96 | 9.76 | 13 | 145117 | 486 | 64353116 |
Venous pressure jugular increased | 19.94 | 9.76 | 19 | 145111 | 1244 | 64352358 |
Neutropenic sepsis | 19.90 | 9.76 | 14 | 145116 | 23258 | 64330344 |
Loss of consciousness | 19.78 | 9.76 | 455 | 144675 | 147910 | 64205692 |
Atrial thrombosis | 19.72 | 9.76 | 29 | 145101 | 3013 | 64350589 |
Impaired work ability | 19.63 | 9.76 | 5 | 145125 | 15214 | 64338388 |
Gastric ulcer haemorrhage | 19.53 | 9.76 | 51 | 145079 | 8092 | 64345510 |
Hepatic cyst | 19.45 | 9.76 | 39 | 145091 | 5201 | 64348401 |
Rhythm idioventricular | 19.41 | 9.76 | 13 | 145117 | 510 | 64353092 |
Neuropathy peripheral | 19.36 | 9.76 | 170 | 144960 | 117355 | 64236247 |
Carotid artery stenosis | 19.32 | 9.76 | 50 | 145080 | 7891 | 64345711 |
Decreased appetite | 19.27 | 9.76 | 795 | 144335 | 280494 | 64073108 |
Adrenal adenoma | 19.21 | 9.76 | 17 | 145113 | 1012 | 64352590 |
Carotid artery disease | 19.16 | 9.76 | 24 | 145106 | 2139 | 64351463 |
Neurotoxicity | 19.15 | 9.76 | 20 | 145110 | 27384 | 64326218 |
Cardio-respiratory arrest | 19.15 | 9.76 | 136 | 144994 | 98257 | 64255345 |
Low density lipoprotein increased | 19.11 | 9.76 | 49 | 145081 | 7691 | 64345911 |
Malabsorption | 19.08 | 9.76 | 35 | 145095 | 4368 | 64349234 |
Glycosylated haemoglobin increased | 19.04 | 9.76 | 79 | 145051 | 15940 | 64337662 |
Thrombocytopenia | 18.98 | 9.76 | 372 | 144758 | 223429 | 64130173 |
Gastritis erosive | 18.97 | 9.76 | 56 | 145074 | 9539 | 64344063 |
Skin reaction | 18.88 | 9.76 | 66 | 145064 | 12286 | 64341316 |
Product substitution issue | 18.87 | 9.76 | 85 | 145045 | 17776 | 64335826 |
Conduction disorder | 18.81 | 9.76 | 28 | 145102 | 2940 | 64350662 |
Forced vital capacity decreased | 18.79 | 9.76 | 20 | 145110 | 1496 | 64352106 |
Pulmonary arterial pressure abnormal | 18.69 | 9.76 | 14 | 145116 | 657 | 64352945 |
Sepsis | 18.60 | 9.76 | 386 | 144744 | 229955 | 64123647 |
Injection site erythema | 18.51 | 9.76 | 89 | 145041 | 70711 | 64282891 |
Fatigue | 18.44 | 9.76 | 1443 | 143687 | 747287 | 63606315 |
Brain contusion | 18.36 | 9.76 | 18 | 145112 | 1221 | 64352381 |
Rectal prolapse | 18.33 | 9.76 | 21 | 145109 | 1705 | 64351897 |
Cytopenia | 18.27 | 9.76 | 6 | 145124 | 15465 | 64338137 |
Multiple sclerosis relapse | 18.18 | 9.76 | 41 | 145089 | 41094 | 64312508 |
Concomitant disease progression | 18.14 | 9.76 | 29 | 145101 | 3240 | 64350362 |
C-reactive protein increased | 18.01 | 9.76 | 307 | 144823 | 94602 | 64259000 |
Ventricular hypokinesia | 17.97 | 9.76 | 48 | 145082 | 7721 | 64345881 |
Blood triglycerides increased | 17.89 | 9.76 | 87 | 145043 | 18779 | 64334823 |
Ophthalmic vein thrombosis | 17.87 | 9.76 | 9 | 145121 | 204 | 64353398 |
Lipid metabolism disorder | 17.73 | 9.76 | 10 | 145120 | 287 | 64353315 |
Fear | 17.70 | 9.76 | 91 | 145039 | 20080 | 64333522 |
Pyonephrosis | 17.64 | 9.76 | 7 | 145123 | 88 | 64353514 |
Irritable bowel syndrome | 17.55 | 9.76 | 36 | 145094 | 37333 | 64316269 |
Product odour abnormal | 17.55 | 9.76 | 17 | 145113 | 1136 | 64352466 |
Blood thyroid stimulating hormone abnormal | 17.38 | 9.76 | 14 | 145116 | 732 | 64352870 |
Mucosal inflammation | 17.35 | 9.76 | 77 | 145053 | 62507 | 64291095 |
Asthma | 17.34 | 9.76 | 306 | 144824 | 94919 | 64258683 |
Peak expiratory flow rate decreased | 17.26 | 9.76 | 13 | 145117 | 615 | 64352987 |
Basal ganglion degeneration | 17.24 | 9.76 | 11 | 145119 | 397 | 64353205 |
Neutrophil function disorder | 17.11 | 9.76 | 5 | 145125 | 22 | 64353580 |
Aortic arteriosclerosis | 17.10 | 9.76 | 46 | 145084 | 7430 | 64346172 |
Gastrointestinal haemorrhage | 17.09 | 9.76 | 404 | 144726 | 131908 | 64221694 |
Impaired healing | 17.01 | 9.76 | 74 | 145056 | 60399 | 64293203 |
Infective pulmonary exacerbation of cystic fibrosis | 17.00 | 9.76 | 3 | 145127 | 11793 | 64341809 |
Pneumothorax traumatic | 17.00 | 9.76 | 9 | 145121 | 227 | 64353375 |
Seroma | 16.95 | 9.76 | 22 | 145108 | 2032 | 64351570 |
Transplant rejection | 16.93 | 9.76 | 9 | 145121 | 17392 | 64336210 |
Aortic valve stenosis | 16.89 | 9.76 | 34 | 145096 | 4546 | 64349056 |
Myalgia | 16.88 | 9.76 | 472 | 144658 | 158145 | 64195457 |
Haemorrhage subcutaneous | 16.84 | 9.76 | 33 | 145097 | 4328 | 64349274 |
Pericardial haemorrhage | 16.83 | 9.76 | 32 | 145098 | 4104 | 64349498 |
Uterine enlargement | 16.81 | 9.76 | 14 | 145116 | 767 | 64352835 |
Periarthritis calcarea | 16.80 | 9.76 | 6 | 145124 | 55 | 64353547 |
Hiatus hernia | 16.80 | 9.76 | 89 | 145041 | 19868 | 64333734 |
Sinus node dysfunction | 16.62 | 9.76 | 43 | 145087 | 6785 | 64346817 |
Cardiac vein perforation | 16.59 | 9.76 | 5 | 145125 | 25 | 64353577 |
Post-anoxic myoclonus | 16.59 | 9.76 | 5 | 145125 | 25 | 64353577 |
Seizure | 16.49 | 9.76 | 270 | 144860 | 166622 | 64186980 |
Neoplasm progression | 16.40 | 9.76 | 43 | 145087 | 40921 | 64312681 |
Gout | 16.35 | 9.76 | 93 | 145037 | 21320 | 64332282 |
Renin decreased | 16.29 | 9.76 | 7 | 145123 | 109 | 64353493 |
Immune reconstitution inflammatory syndrome | 16.27 | 9.76 | 4 | 145126 | 12466 | 64341136 |
Malignant melanoma | 16.26 | 9.76 | 65 | 145065 | 12899 | 64340703 |
Blood pressure abnormal | 16.24 | 9.76 | 70 | 145060 | 14365 | 64339237 |
Toxic skin eruption | 16.23 | 9.76 | 86 | 145044 | 19198 | 64334404 |
Hepatic cancer | 16.21 | 9.76 | 45 | 145085 | 7403 | 64346199 |
Pancytopenia | 16.16 | 9.76 | 226 | 144904 | 143083 | 64210519 |
Hypercholesterolaemia | 16.12 | 9.76 | 73 | 145057 | 15300 | 64338302 |
Product monitoring error | 16.11 | 9.76 | 37 | 145093 | 5417 | 64348185 |
Dyspnoea exertional | 16.05 | 9.76 | 244 | 144886 | 73486 | 64280116 |
Blood alkaline phosphatase increased | 15.83 | 9.76 | 195 | 144935 | 56084 | 64297518 |
Dementia Alzheimer's type | 15.81 | 9.76 | 15 | 145115 | 977 | 64352625 |
Therapeutic drug monitoring analysis incorrectly performed | 15.78 | 9.76 | 8 | 145122 | 184 | 64353418 |
Cardiac myxoma | 15.78 | 9.76 | 7 | 145123 | 118 | 64353484 |
Nausea | 15.72 | 9.76 | 1539 | 143591 | 784261 | 63569341 |
Tissue infiltration | 15.69 | 9.76 | 12 | 145118 | 581 | 64353021 |
Altered state of consciousness | 15.69 | 9.76 | 142 | 144988 | 37760 | 64315842 |
Hypertrophic osteoarthropathy | 15.68 | 9.76 | 7 | 145123 | 120 | 64353482 |
Gouty arthritis | 15.61 | 9.76 | 17 | 145113 | 1305 | 64352297 |
Coronary artery bypass | 15.60 | 9.76 | 38 | 145092 | 5777 | 64347825 |
Erectile dysfunction | 15.58 | 9.76 | 63 | 145067 | 12564 | 64341038 |
Microalbuminuria | 15.57 | 9.76 | 14 | 145116 | 851 | 64352751 |
Pigmentation disorder | 15.56 | 9.76 | 33 | 145097 | 4579 | 64349023 |
Aggression | 15.30 | 9.76 | 53 | 145077 | 46179 | 64307423 |
Renal injury | 15.24 | 9.76 | 72 | 145058 | 15357 | 64338245 |
Hypertensive emergency | 15.19 | 9.76 | 22 | 145108 | 2254 | 64351348 |
Acute hepatic failure | 15.15 | 9.76 | 22 | 145108 | 26090 | 64327512 |
Pyometra | 15.15 | 9.76 | 6 | 145124 | 75 | 64353527 |
Somnolence | 15.07 | 9.76 | 346 | 144784 | 203299 | 64150303 |
Aortic valve incompetence | 15.05 | 9.76 | 47 | 145083 | 8254 | 64345348 |
Goitre | 14.98 | 9.76 | 34 | 145096 | 4939 | 64348663 |
Subacute hepatic failure | 14.93 | 9.76 | 8 | 145122 | 207 | 64353395 |
Mydriasis | 14.78 | 9.76 | 8 | 145122 | 15304 | 64338298 |
Merycism | 14.76 | 9.76 | 8 | 145122 | 212 | 64353390 |
Myoglobin blood increased | 14.74 | 9.76 | 24 | 145106 | 2723 | 64350879 |
Acquired C1 inhibitor deficiency | 14.64 | 9.76 | 4 | 145126 | 13 | 64353589 |
Left ventricular dysfunction | 14.54 | 9.76 | 76 | 145054 | 16878 | 64336724 |
Haemophagocytic lymphohistiocytosis | 14.53 | 9.76 | 11 | 145119 | 17598 | 64336004 |
Nephrotic syndrome | 14.52 | 9.76 | 51 | 145079 | 9516 | 64344086 |
Hyperlipidaemia | 14.51 | 9.76 | 95 | 145035 | 22881 | 64330721 |
Acral lentiginous melanoma | 14.49 | 9.76 | 5 | 145125 | 41 | 64353561 |
Adrenal cyst | 14.35 | 9.76 | 6 | 145124 | 87 | 64353515 |
Hypercreatininaemia | 14.30 | 9.76 | 13 | 145117 | 802 | 64352800 |
Progressive multifocal leukoencephalopathy | 14.28 | 9.76 | 12 | 145118 | 18220 | 64335382 |
Metastatic bronchial carcinoma | 14.26 | 9.76 | 8 | 145122 | 227 | 64353375 |
Fractured coccyx | 14.25 | 9.76 | 14 | 145116 | 952 | 64352650 |
Malignant neoplasm progression | 14.19 | 9.76 | 174 | 144956 | 112697 | 64240905 |
Diverticulum intestinal haemorrhagic | 14.19 | 9.76 | 26 | 145104 | 3243 | 64350359 |
Loss of personal independence in daily activities | 14.17 | 9.76 | 100 | 145030 | 72354 | 64281248 |
Abdominal tenderness | 14.16 | 9.76 | 50 | 145080 | 9355 | 64344247 |
Diastolic dysfunction | 14.07 | 9.76 | 48 | 145082 | 8827 | 64344775 |
Painful respiration | 14 | 9.76 | 25 | 145105 | 3056 | 64350546 |
Duodenal ulcer | 14.00 | 9.76 | 67 | 145063 | 14368 | 64339234 |
Therapy partial responder | 13.94 | 9.76 | 3 | 145127 | 10245 | 64343357 |
Macular degeneration | 13.94 | 9.76 | 36 | 145094 | 5674 | 64347928 |
Articular calcification | 13.93 | 9.76 | 6 | 145124 | 94 | 64353508 |
Nephrogenic anaemia | 13.87 | 9.76 | 26 | 145104 | 3299 | 64350303 |
Hypochloraemia | 13.87 | 9.76 | 20 | 145110 | 2041 | 64351561 |
Carotid artery occlusion | 13.85 | 9.76 | 29 | 145101 | 3988 | 64349614 |
Mouth ulceration | 13.81 | 9.76 | 33 | 145097 | 32411 | 64321191 |
Surfactant protein increased | 13.80 | 9.76 | 4 | 145126 | 17 | 64353585 |
Abdominal discomfort | 13.71 | 9.76 | 309 | 144821 | 182013 | 64171589 |
Staphylococcal infection | 13.66 | 9.76 | 63 | 145067 | 50615 | 64302987 |
Costal cartilage fracture | 13.65 | 9.76 | 8 | 145122 | 247 | 64353355 |
Accidental exposure to product | 13.61 | 9.76 | 24 | 145106 | 26340 | 64327262 |
Anhedonia | 13.57 | 9.76 | 64 | 145066 | 13642 | 64339960 |
Rhinitis | 13.52 | 9.76 | 54 | 145076 | 10711 | 64342891 |
Venoocclusive liver disease | 13.49 | 9.76 | 3 | 145127 | 10012 | 64343590 |
Lung diffusion test decreased | 13.46 | 9.76 | 15 | 145115 | 1181 | 64352421 |
Hepatic calcification | 13.39 | 9.76 | 9 | 145121 | 355 | 64353247 |
Anaphylactic reaction | 13.31 | 9.76 | 95 | 145035 | 68569 | 64285033 |
Extrasystoles | 13.30 | 9.76 | 39 | 145091 | 6619 | 64346983 |
Miscarriage of partner | 13.22 | 9.76 | 3 | 145127 | 3 | 64353599 |
Faecaloma | 13.19 | 9.76 | 50 | 145080 | 9678 | 64343924 |
Azotaemia | 13.17 | 9.76 | 42 | 145088 | 7460 | 64346142 |
Recalled product administered | 13.15 | 9.76 | 12 | 145118 | 744 | 64352858 |
Blood cholesterol increased | 13.03 | 9.76 | 171 | 144959 | 49895 | 64303707 |
Cerebral arteriosclerosis | 13.00 | 9.76 | 12 | 145118 | 755 | 64352847 |
Kyphosis | 12.97 | 9.76 | 21 | 145109 | 2372 | 64351230 |
Dystonia | 12.92 | 9.76 | 14 | 145116 | 18851 | 64334751 |
Iron deficiency anaemia | 12.92 | 9.76 | 89 | 145041 | 21800 | 64331802 |
Hepatic enzyme increased | 12.91 | 9.76 | 210 | 144920 | 129733 | 64223869 |
Transitional cell cancer of the renal pelvis and ureter | 12.88 | 9.76 | 5 | 145125 | 59 | 64353543 |
Cognitive disorder | 12.85 | 9.76 | 72 | 145058 | 55015 | 64298587 |
Epstein-Barr virus infection | 12.84 | 9.76 | 6 | 145124 | 12482 | 64341120 |
Bezold-Jarisch reflex | 12.67 | 9.76 | 4 | 145126 | 24 | 64353578 |
Nasopharyngitis | 12.65 | 9.76 | 340 | 144790 | 195733 | 64157869 |
Erythema multiforme | 12.52 | 9.76 | 69 | 145061 | 15632 | 64337970 |
Premature delivery | 12.51 | 9.76 | 14 | 145116 | 18575 | 64335027 |
Emotional distress | 12.46 | 9.76 | 130 | 145000 | 35908 | 64317694 |
Urticaria | 12.44 | 9.76 | 245 | 144885 | 147072 | 64206530 |
Arrhythmogenic right ventricular dysplasia | 12.40 | 9.76 | 4 | 145126 | 26 | 64353576 |
Peripheral swelling | 12.39 | 9.76 | 367 | 144763 | 208786 | 64144816 |
Therapy non-responder | 12.38 | 9.76 | 92 | 145038 | 65807 | 64287795 |
Device related infection | 12.37 | 9.76 | 32 | 145098 | 30594 | 64323008 |
Infusion site pain | 12.33 | 9.76 | 4 | 145126 | 10393 | 64343209 |
Anaesthesia | 12.25 | 9.76 | 9 | 145121 | 410 | 64353192 |
Bladder cancer | 12.18 | 9.76 | 53 | 145077 | 10921 | 64342681 |
Liver disorder | 12.17 | 9.76 | 178 | 144952 | 53173 | 64300429 |
Immunodeficiency | 12.16 | 9.76 | 11 | 145119 | 16113 | 64337489 |
Live birth | 12.12 | 9.76 | 5 | 145125 | 11199 | 64342403 |
Electrocardiogram ST segment depression | 12.12 | 9.76 | 29 | 145101 | 4360 | 64349242 |
Metastases to bone | 12.07 | 9.76 | 17 | 145113 | 20418 | 64333184 |
Actinic keratosis | 12.03 | 9.76 | 32 | 145098 | 5133 | 64348469 |
Renal artery stent placement | 12.02 | 9.76 | 4 | 145126 | 29 | 64353573 |
Prerenal failure | 11.98 | 9.76 | 24 | 145106 | 3198 | 64350404 |
Oedema | 11.95 | 9.76 | 281 | 144849 | 91654 | 64261948 |
Gait disturbance | 11.87 | 9.76 | 487 | 144643 | 171668 | 64181934 |
Withdrawal hypertension | 11.83 | 9.76 | 8 | 145122 | 319 | 64353283 |
Hypersensitivity | 11.81 | 9.76 | 344 | 144786 | 196108 | 64157494 |
Chronic obstructive pulmonary disease | 11.78 | 9.76 | 225 | 144905 | 70823 | 64282779 |
Haemangioma | 11.75 | 9.76 | 20 | 145110 | 2354 | 64351248 |
Sprue-like enteropathy | 11.75 | 9.76 | 13 | 145117 | 1016 | 64352586 |
Neutrophil count decreased | 11.70 | 9.76 | 114 | 145016 | 77082 | 64276520 |
Chronic leukaemia | 11.70 | 9.76 | 3 | 145127 | 7 | 64353595 |
Hepatitis E antibody positive | 11.68 | 9.76 | 6 | 145124 | 142 | 64353460 |
Putamen haemorrhage | 11.66 | 9.76 | 9 | 145121 | 442 | 64353160 |
Aortic valve sclerosis | 11.63 | 9.76 | 16 | 145114 | 1563 | 64352039 |
Eczema | 11.62 | 9.76 | 110 | 145020 | 29610 | 64323992 |
Therapy cessation | 11.61 | 9.76 | 36 | 145094 | 32453 | 64321149 |
Multiple injuries | 11.59 | 9.76 | 24 | 145106 | 3275 | 64350327 |
Right ventricular failure | 11.58 | 9.76 | 19 | 145111 | 21452 | 64332150 |
Basal ganglia haemorrhage | 11.51 | 9.76 | 15 | 145115 | 1391 | 64352211 |
Cytomegalovirus viraemia | 11.45 | 9.76 | 5 | 145125 | 10823 | 64342779 |
Cerebellar ischaemia | 11.42 | 9.76 | 6 | 145124 | 149 | 64353453 |
Frustration tolerance decreased | 11.40 | 9.76 | 35 | 145095 | 6090 | 64347512 |
Injection site swelling | 11.39 | 9.76 | 51 | 145079 | 41302 | 64312300 |
Acute phosphate nephropathy | 11.37 | 9.76 | 4 | 145126 | 35 | 64353567 |
Joint stiffness | 11.36 | 9.76 | 33 | 145097 | 30371 | 64323231 |
Osteoarthritis | 11.34 | 9.76 | 203 | 144927 | 63133 | 64290469 |
Activated partial thromboplastin time prolonged | 11.34 | 9.76 | 58 | 145072 | 12773 | 64340829 |
Pulmonary oedema | 11.33 | 9.76 | 244 | 144886 | 78430 | 64275172 |
Stenosis | 11.33 | 9.76 | 17 | 145113 | 1798 | 64351804 |
Incorrect route of product administration | 11.32 | 9.76 | 22 | 145108 | 23276 | 64330326 |
Panniculitis | 11.29 | 9.76 | 3 | 145127 | 8876 | 64344726 |
Sudden cardiac death | 11.28 | 9.76 | 29 | 145101 | 4558 | 64349044 |
Peripheral vascular disorder | 11.27 | 9.76 | 39 | 145091 | 7222 | 64346380 |
Brain stem infarction | 11.27 | 9.76 | 17 | 145113 | 1806 | 64351796 |
Body height decreased | 11.23 | 9.76 | 40 | 145090 | 7514 | 64346088 |
Multiple drug therapy | 11.17 | 9.76 | 19 | 145111 | 2235 | 64351367 |
Perihepatic discomfort | 11.16 | 9.76 | 3 | 145127 | 9 | 64353593 |
Hepatobiliary cancer | 11.16 | 9.76 | 3 | 145127 | 9 | 64353593 |
Bronchopulmonary aspergillosis | 11.15 | 9.76 | 16 | 145114 | 19069 | 64334533 |
Hyponatraemic syndrome | 11.15 | 9.76 | 11 | 145119 | 752 | 64352850 |
Low density lipoprotein decreased | 11.13 | 9.76 | 13 | 145117 | 1077 | 64352525 |
Fibromyalgia | 11.13 | 9.76 | 42 | 145088 | 35689 | 64317913 |
Anuria | 11.13 | 9.76 | 77 | 145053 | 18887 | 64334715 |
Acute coronary syndrome | 11.09 | 9.76 | 78 | 145052 | 19232 | 64334370 |
Cutaneous lymphoma | 11.08 | 9.76 | 7 | 145123 | 248 | 64353354 |
Hypoxia | 11.04 | 9.76 | 136 | 144994 | 88013 | 64265589 |
Large intestine polyp | 11.02 | 9.76 | 51 | 145079 | 10786 | 64342816 |
Metamyelocyte count increased | 10.97 | 9.76 | 10 | 145120 | 619 | 64352983 |
Arteriosclerosis coronary artery | 10.92 | 9.76 | 66 | 145064 | 15463 | 64338139 |
Hepatitis E virus test positive | 10.87 | 9.76 | 6 | 145124 | 165 | 64353437 |
Suspected suicide | 10.86 | 9.76 | 3 | 145127 | 8651 | 64344951 |
Renal neoplasm | 10.86 | 9.76 | 16 | 145114 | 1665 | 64351937 |
Mood swings | 10.86 | 9.76 | 14 | 145116 | 17454 | 64336148 |
Aortic dissection | 10.84 | 9.76 | 24 | 145106 | 3428 | 64350174 |
Angioplasty | 10.83 | 9.76 | 16 | 145114 | 1669 | 64351933 |
Orthopnoea | 10.82 | 9.76 | 45 | 145085 | 9089 | 64344513 |
Blood chloride decreased | 10.80 | 9.76 | 39 | 145091 | 7377 | 64346225 |
Exercise tolerance decreased | 10.77 | 9.76 | 40 | 145090 | 7670 | 64345932 |
Infarction | 10.75 | 9.76 | 26 | 145104 | 3934 | 64349668 |
Post streptococcal glomerulonephritis | 10.72 | 9.76 | 4 | 145126 | 42 | 64353560 |
Chest wall haematoma | 10.69 | 9.76 | 8 | 145122 | 375 | 64353227 |
Rash maculo-papular | 10.68 | 9.76 | 62 | 145068 | 46964 | 64306638 |
Small intestine carcinoma | 10.62 | 9.76 | 11 | 145119 | 797 | 64352805 |
Left ventricular hypertrophy | 10.62 | 9.76 | 46 | 145084 | 9460 | 64344142 |
Ear infection | 10.61 | 9.76 | 23 | 145107 | 23381 | 64330221 |
Subdural haematoma | 10.56 | 9.76 | 103 | 145027 | 27951 | 64325651 |
Protein urine present | 10.51 | 9.76 | 44 | 145086 | 8912 | 64344690 |
Oscillopsia | 10.46 | 9.76 | 6 | 145124 | 178 | 64353424 |
Haematocrit decreased | 10.44 | 9.76 | 177 | 144953 | 54478 | 64299124 |
Skin texture abnormal | 10.43 | 9.76 | 8 | 145122 | 389 | 64353213 |
Haemodialysis | 10.41 | 9.76 | 70 | 145060 | 17007 | 64336595 |
Peripheral arterial occlusive disease | 10.39 | 9.76 | 37 | 145093 | 6950 | 64346652 |
Blood phosphorus abnormal | 10.37 | 9.76 | 7 | 145123 | 278 | 64353324 |
Brain stem haemorrhage | 10.36 | 9.76 | 15 | 145115 | 1536 | 64352066 |
Laryngeal haemorrhage | 10.32 | 9.76 | 4 | 145126 | 47 | 64353555 |
Subarachnoid haemorrhage | 10.31 | 9.76 | 74 | 145056 | 18364 | 64335238 |
Aspergillus infection | 10.31 | 9.76 | 13 | 145117 | 16366 | 64337236 |
Leukopenia | 10.26 | 9.76 | 163 | 144967 | 101079 | 64252523 |
Cutaneous listeriosis | 10.24 | 9.76 | 4 | 145126 | 48 | 64353554 |
Choroidal detachment | 10.21 | 9.76 | 9 | 145121 | 533 | 64353069 |
Bacteraemia | 10.21 | 9.76 | 29 | 145101 | 26882 | 64326720 |
Liver function test abnormal | 10.19 | 9.76 | 85 | 145045 | 59316 | 64294286 |
Cardiac valve sclerosis | 10.19 | 9.76 | 5 | 145125 | 107 | 64353495 |
Diabetic nephropathy | 10.15 | 9.76 | 20 | 145110 | 2634 | 64350968 |
Incision site oedema | 10.13 | 9.76 | 3 | 145127 | 14 | 64353588 |
Hallucination, auditory | 10.10 | 9.76 | 14 | 145116 | 16925 | 64336677 |
Grip strength decreased | 10.10 | 9.76 | 7 | 145123 | 11717 | 64341885 |
Sleep disorder due to a general medical condition | 10.07 | 9.76 | 3 | 145127 | 8231 | 64345371 |
Lipoedema | 10.05 | 9.76 | 6 | 145124 | 192 | 64353410 |
Cholangiocarcinoma | 9.98 | 9.76 | 17 | 145113 | 2001 | 64351601 |
Aspartate aminotransferase increased | 9.97 | 9.76 | 346 | 144784 | 119442 | 64234160 |
No adverse event | 9.96 | 9.76 | 32 | 145098 | 28529 | 64325073 |
Gastrointestinal stromal tumour | 9.95 | 9.76 | 14 | 145116 | 1397 | 64352205 |
Eosinophil count increased | 9.94 | 9.76 | 60 | 145070 | 14052 | 64339550 |
Product complaint | 9.85 | 9.76 | 53 | 145077 | 11901 | 64341701 |
Labelled drug-drug interaction medication error | 9.83 | 9.76 | 84 | 145046 | 21978 | 64331624 |
Reaction to colouring | 9.80 | 9.76 | 3 | 145127 | 16 | 64353586 |
Hypoparathyroidism | 9.77 | 9.76 | 11 | 145119 | 876 | 64352726 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Renal failure | 38.31 | 28.83 | 19 | 294 | 254 | 84111 |
Source | Code | Description |
---|---|---|
ATC | C09CA03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN Angiotensin II receptor blockers (ARBs), plain |
ATC | C09DA03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and diuretics |
ATC | C09DB01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB08 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX02 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX05 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C10BX10 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA MoA | N0000000070 | Angiotensin 2 Receptor Antagonists |
FDA EPC | N0000175561 | Angiotensin 2 Receptor Blocker |
MeSH PA | D047228 | Angiotensin II Type 1 Receptor Blockers |
MeSH PA | D057911 | Angiotensin Receptor Antagonists |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:61016 | angiotensin receptor antagonists |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Left ventricular cardiac dysfunction | indication | 429589006 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Diabetic renal disease | off-label use | 127013003 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Nondiabetic Proteinuric Nephropathy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Obstruction of bile duct | contraindication | 30144000 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Azotemia | contraindication | 445009001 | |
Severe Aortic Valve Stenosis | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.8 | acidic |
pKa2 | 4.44 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
24MG;26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 8796331 | Jan. 14, 2023 | TREATMENT OF HEART FAILURE |
49MG;51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 8796331 | Jan. 14, 2023 | TREATMENT OF HEART FAILURE |
97MG;103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 8796331 | Jan. 14, 2023 | TREATMENT OF HEART FAILURE |
24MG;26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9388134 | Nov. 8, 2026 | TREATMENT OF HEART FAILURE |
49MG;51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9388134 | Nov. 8, 2026 | TREATMENT OF HEART FAILURE |
97MG;103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9388134 | Nov. 8, 2026 | TREATMENT OF HEART FAILURE |
EQ 5MG BASE;80MG | BYVALSON | ALLERGAN | N206302 | June 3, 2016 | DISCN | TABLET | ORAL | 7838552 | Oct. 4, 2027 | METHOD OF TREATING HYPERTENSION |
24MG;26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 11135192 | Aug. 22, 2033 | TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION |
24MG;26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9517226 | Aug. 22, 2033 | TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION |
24MG;26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9937143 | Aug. 22, 2033 | TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION |
49MG;51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 11135192 | Aug. 22, 2033 | TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION |
49MG;51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9517226 | Aug. 22, 2033 | TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION |
49MG;51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9937143 | Aug. 22, 2033 | TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION |
97MG;103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 11135192 | Aug. 22, 2033 | TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION |
97MG;103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9517226 | Aug. 22, 2033 | TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION |
97MG;103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9937143 | Aug. 22, 2033 | TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION |
24MG;26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 11058667 | May 9, 2036 | TREATING CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION IN PATIENTS NOT TAKING AN ACE INHIBITOR OR AN ARB OR PREVIOUSLY TAKING LOW DOSES OF THESE AGENTS, BY TITRATING UP FROM HALF THE USUALLY RECOMMENDED STARTING DOSE |
49MG;51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 11058667 | May 9, 2036 | TREATING CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION IN PATIENTS NOT TAKING AN ACE INHIBITOR OR AN ARB OR PREVIOUSLY TAKING LOW DOSES OF THESE AGENTS, BY TITRATING UP FROM HALF THE USUALLY RECOMMENDED STARTING DOSE |
97MG;103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 11058667 | May 9, 2036 | TREATING CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION IN PATIENTS NOT TAKING AN ACE INHIBITOR OR AN ARB OR PREVIOUSLY TAKING LOW DOSES OF THESE AGENTS, BY TITRATING UP FROM HALF THE USUALLY RECOMMENDED STARTING DOSE |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
24MG;26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Oct. 1, 2022 | NEW PATIENT POPULATION |
49MG;51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Oct. 1, 2022 | NEW PATIENT POPULATION |
97MG;103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Oct. 1, 2022 | NEW PATIENT POPULATION |
24MG;26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | April 1, 2023 | PEDIATRIC EXCLUSIVITY |
49MG;51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | April 1, 2023 | PEDIATRIC EXCLUSIVITY |
97MG;103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | April 1, 2023 | PEDIATRIC EXCLUSIVITY |
24MG;26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Feb. 16, 2024 | LABELING REVISIONS RELATED TO CLINICAL STUDIES |
49MG;51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Feb. 16, 2024 | LABELING REVISIONS RELATED TO CLINICAL STUDIES |
97MG;103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Feb. 16, 2024 | LABELING REVISIONS RELATED TO CLINICAL STUDIES |
160MG | DIOVAN | NOVARTIS | N021283 | July 18, 2001 | RX | TABLET | ORAL | April 19, 2024 | NEW PATIENT POPULATION |
40MG | DIOVAN | NOVARTIS | N021283 | Aug. 14, 2002 | RX | TABLET | ORAL | April 19, 2024 | NEW PATIENT POPULATION |
80MG | DIOVAN | NOVARTIS | N021283 | July 18, 2001 | RX | TABLET | ORAL | April 19, 2024 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Type-1 angiotensin II receptor | GPCR | ANTAGONIST | Ki | 5.33 | CHEMBL | CHEMBL | |||
Platelet glycoprotein VI | Unclassified | Kd | 4 | CHEMBL | |||||
Type-1B angiotensin II receptor | GPCR | IC50 | 8.72 | CHEMBL | |||||
Type-1A angiotensin II receptor | GPCR | IC50 | 8.47 | CHEMBL | |||||
Angiotensin II receptor (AT-1) type-1 | GPCR | IC50 | 8.57 | CHEMBL |
ID | Source |
---|---|
D00400 | KEGG_DRUG |
4020986 | VANDF |
C0216784 | UMLSCUI |
CHEBI:9927 | CHEBI |
U35 | PDB_CHEM_ID |
CHEMBL1069 | ChEMBL_ID |
D000068756 | MESH_DESCRIPTOR_UI |
DB00177 | DRUGBANK_ID |
3937 | IUPHAR_LIGAND_ID |
7016 | INN_ID |
80M03YXJ7I | UNII |
60846 | PUBCHEM_CID |
216652 | RXNORM |
53010 | MMSL |
5663 | MMSL |
8844 | MMSL |
d04113 | MMSL |
006279 | NDDF |
108581009 | SNOMEDCT_US |
386876001 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0314 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0314 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0315 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0315 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0358 | TABLET | 80 mg | ORAL | NDA | 33 sections |
Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0358 | TABLET | 80 mg | ORAL | NDA | 33 sections |
Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0359 | TABLET | 160 mg | ORAL | NDA | 33 sections |
Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0359 | TABLET | 160 mg | ORAL | NDA | 33 sections |
Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0360 | TABLET | 320 mg | ORAL | NDA | 33 sections |
Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0360 | TABLET | 320 mg | ORAL | NDA | 33 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0383 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0383 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0423 | TABLET | 40 mg | ORAL | NDA | 33 sections |
Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0423 | TABLET | 40 mg | ORAL | NDA | 33 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0471 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0471 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0472 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 31 sections |
Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0472 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0488 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0488 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0489 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0489 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0490 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0490 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0491 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0491 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0559 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0559 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0560 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0560 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 31 sections |