valsartan Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin II receptor antagonists, antihypertensive (non-peptidic) | 2806 | 137862-53-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A tetrazole derivative and ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to treat HYPERTENSION.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 80 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.18 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 13 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 10.50 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 23 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.49 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.04 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 9.50 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 23, 1996 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypotension | 2498.54 | 23.16 | 886 | 10026 | 31550 | 2315623 |
| Dizziness | 1686.35 | 23.16 | 791 | 10121 | 57874 | 2289299 |
| Blood pressure increased | 1433.89 | 23.16 | 499 | 10413 | 16487 | 2330686 |
| Dyspnoea | 1219.52 | 23.16 | 702 | 10210 | 78031 | 2269142 |
| Malaise | 1133.01 | 23.16 | 595 | 10317 | 54990 | 2292183 |
| Cardiac failure | 1021.38 | 23.16 | 356 | 10556 | 11738 | 2335435 |
| Acute kidney injury | 987.57 | 23.16 | 438 | 10474 | 27684 | 2319489 |
| Cough | 912.88 | 23.16 | 436 | 10476 | 32681 | 2314492 |
| Hyperkalaemia | 903.93 | 23.16 | 273 | 10639 | 5620 | 2341553 |
| Hyponatraemia | 872.29 | 23.16 | 325 | 10587 | 13000 | 2334173 |
| Hypertension | 832.85 | 23.16 | 386 | 10526 | 26975 | 2320198 |
| Fall | 754.37 | 23.16 | 431 | 10481 | 46668 | 2300505 |
| Blood pressure decreased | 733.48 | 23.16 | 260 | 10652 | 8976 | 2338197 |
| Fatigue | 686.19 | 23.16 | 505 | 10407 | 84368 | 2262805 |
| Blood creatinine increased | 685.44 | 23.16 | 256 | 10656 | 10277 | 2336896 |
| Blood pressure inadequately controlled | 658.59 | 23.16 | 145 | 10767 | 755 | 2346418 |
| Angioedema | 604.83 | 23.16 | 220 | 10692 | 8176 | 2338997 |
| Oedema peripheral | 590.44 | 23.16 | 292 | 10620 | 23471 | 2323702 |
| Syncope | 530.73 | 23.16 | 244 | 10668 | 16631 | 2330542 |
| Feeling abnormal | 507.35 | 23.16 | 263 | 10649 | 23318 | 2323855 |
| Diabetes mellitus | 490.21 | 23.16 | 183 | 10729 | 7312 | 2339861 |
| Asthenia | 488.80 | 23.16 | 327 | 10585 | 46599 | 2300574 |
| Renal impairment | 478.15 | 23.16 | 195 | 10717 | 9897 | 2337276 |
| Death | 469.72 | 23.16 | 398 | 10514 | 81070 | 2266103 |
| Headache | 458.68 | 23.16 | 390 | 10522 | 79789 | 2267384 |
| Pruritus | 429.53 | 23.16 | 293 | 10619 | 43047 | 2304126 |
| Blood potassium increased | 429.49 | 23.16 | 123 | 10789 | 2073 | 2345100 |
| Atrial fibrillation | 423.00 | 23.16 | 196 | 10716 | 13572 | 2333601 |
| Renal failure | 406.16 | 23.16 | 205 | 10707 | 17144 | 2330029 |
| Drug ineffective | 403.45 | 23.16 | 403 | 10509 | 101221 | 2245952 |
| Wrong technique in product usage process | 378.31 | 23.16 | 204 | 10708 | 19544 | 2327629 |
| Chest pain | 363.82 | 23.16 | 225 | 10687 | 27912 | 2319261 |
| General physical health deterioration | 348.25 | 23.16 | 173 | 10739 | 13966 | 2333207 |
| Blood pressure fluctuation | 344.24 | 23.16 | 100 | 10812 | 1775 | 2345398 |
| Cerebrovascular accident | 341.12 | 23.16 | 192 | 10720 | 19994 | 2327179 |
| Product prescribing error | 339.54 | 23.16 | 110 | 10802 | 2850 | 2344323 |
| Nausea | 333.76 | 23.16 | 382 | 10530 | 111807 | 2235366 |
| Weight decreased | 331.96 | 23.16 | 213 | 10699 | 28158 | 2319015 |
| Gait disturbance | 326.60 | 23.16 | 194 | 10718 | 22351 | 2324822 |
| Weight increased | 323.03 | 23.16 | 192 | 10720 | 22145 | 2325028 |
| Blood urea increased | 310.52 | 23.16 | 108 | 10804 | 3497 | 2343676 |
| Dehydration | 307.74 | 23.16 | 186 | 10726 | 22109 | 2325064 |
| Rash | 303.89 | 23.16 | 272 | 10640 | 59286 | 2287887 |
| Myocardial infarction | 302.75 | 23.16 | 174 | 10738 | 18839 | 2328334 |
| Memory impairment | 288.50 | 23.16 | 148 | 10764 | 12775 | 2334398 |
| Peripheral swelling | 277.33 | 23.16 | 160 | 10752 | 17437 | 2329736 |
| Blood pressure diastolic decreased | 271.98 | 23.16 | 74 | 10838 | 1021 | 2346152 |
| Loss of consciousness | 270.38 | 23.16 | 161 | 10751 | 18606 | 2328567 |
| Angina pectoris | 266.45 | 23.16 | 99 | 10813 | 3888 | 2343285 |
| Diarrhoea | 263.96 | 23.16 | 294 | 10618 | 83270 | 2263903 |
| Blood glucose increased | 260.64 | 23.16 | 136 | 10776 | 12154 | 2335019 |
| Hypokalaemia | 252.27 | 23.16 | 127 | 10785 | 10527 | 2336646 |
| Pneumonia | 241.03 | 23.16 | 220 | 10692 | 49076 | 2298097 |
| Glomerular filtration rate decreased | 240.60 | 23.16 | 72 | 10840 | 1421 | 2345752 |
| Oligohydramnios | 239.00 | 23.16 | 65 | 10847 | 895 | 2346278 |
| Decreased appetite | 238.42 | 23.16 | 175 | 10737 | 28716 | 2318457 |
| Inappropriate schedule of product administration | 230.41 | 23.16 | 125 | 10787 | 12079 | 2335094 |
| Arrhythmia | 226.82 | 23.16 | 99 | 10813 | 5929 | 2341244 |
| Oedema | 219.41 | 23.16 | 114 | 10798 | 10089 | 2337084 |
| Vomiting | 219.11 | 23.16 | 248 | 10664 | 71354 | 2275819 |
| Palpitations | 218.43 | 23.16 | 134 | 10778 | 16322 | 2330851 |
| Blood pressure systolic increased | 216.61 | 23.16 | 74 | 10838 | 2265 | 2344908 |
| Pain in extremity | 204.18 | 23.16 | 188 | 10724 | 42352 | 2304821 |
| Fluid retention | 199.70 | 23.16 | 95 | 10817 | 6951 | 2340222 |
| Lip swelling | 197.18 | 23.16 | 84 | 10828 | 4737 | 2342436 |
| Contraindicated product administered | 194.46 | 23.16 | 73 | 10839 | 2948 | 2344225 |
| Asthma | 191.87 | 23.16 | 108 | 10804 | 11206 | 2335967 |
| Confusional state | 190.73 | 23.16 | 143 | 10769 | 24201 | 2322972 |
| Ejection fraction decreased | 188.75 | 23.16 | 70 | 10842 | 2731 | 2344442 |
| Insomnia | 187.77 | 23.16 | 145 | 10767 | 25642 | 2321531 |
| Cerebral infarction | 187.07 | 23.16 | 79 | 10833 | 4358 | 2342815 |
| No adverse event | 186.51 | 23.16 | 100 | 10812 | 9428 | 2337745 |
| Anaemia | 185.09 | 23.16 | 163 | 10749 | 34629 | 2312544 |
| Urinary tract infection | 183.16 | 23.16 | 152 | 10760 | 29790 | 2317383 |
| Pain | 181.85 | 23.16 | 210 | 10702 | 61647 | 2285526 |
| Orthostatic hypotension | 179.61 | 23.16 | 68 | 10844 | 2811 | 2344362 |
| Hypersensitivity | 179.07 | 23.16 | 136 | 10776 | 23457 | 2323716 |
| Cardiac disorder | 175.50 | 23.16 | 90 | 10822 | 7743 | 2339430 |
| Visual impairment | 174.76 | 23.16 | 103 | 10809 | 11652 | 2335521 |
| Drug intolerance | 172.59 | 23.16 | 108 | 10804 | 13609 | 2333564 |
| Heart rate increased | 169.54 | 23.16 | 99 | 10813 | 11006 | 2336167 |
| Abdominal discomfort | 167.46 | 23.16 | 116 | 10796 | 17340 | 2329833 |
| Swollen tongue | 166.70 | 23.16 | 77 | 10835 | 5266 | 2341907 |
| Cardiogenic shock | 163.25 | 23.16 | 61 | 10851 | 2430 | 2344743 |
| Blood pressure abnormal | 161.99 | 23.16 | 55 | 10857 | 1650 | 2345523 |
| Nervousness | 159.45 | 23.16 | 74 | 10838 | 5115 | 2342058 |
| Concomitant disease aggravated | 159.38 | 23.16 | 48 | 10864 | 968 | 2346205 |
| Swelling face | 156.55 | 23.16 | 89 | 10823 | 9404 | 2337769 |
| Chest discomfort | 154.27 | 23.16 | 103 | 10809 | 14492 | 2332681 |
| Renal disorder | 153.63 | 23.16 | 69 | 10843 | 4419 | 2342754 |
| Chronic kidney disease | 149.57 | 23.16 | 66 | 10846 | 4052 | 2343121 |
| Hypertensive crisis | 148.29 | 23.16 | 57 | 10855 | 2456 | 2344717 |
| Myalgia | 147.93 | 23.16 | 121 | 10791 | 23212 | 2323961 |
| Muscle spasms | 147.68 | 23.16 | 117 | 10795 | 21449 | 2325724 |
| Mitral valve incompetence | 147.48 | 23.16 | 57 | 10855 | 2493 | 2344680 |
| Heart rate decreased | 143.54 | 23.16 | 62 | 10850 | 3614 | 2343559 |
| Breast cancer | 140.58 | 23.16 | 83 | 10829 | 9412 | 2337761 |
| Cardiac failure chronic | 138.35 | 23.16 | 36 | 10876 | 413 | 2346760 |
| Nasopharyngitis | 134.83 | 23.16 | 112 | 10800 | 21944 | 2325229 |
| Tachycardia | 134.25 | 23.16 | 99 | 10813 | 16310 | 2330863 |
| C-reactive protein increased | 131.84 | 23.16 | 69 | 10843 | 6186 | 2340987 |
| Lymphatic fistula | 131.62 | 23.16 | 21 | 10891 | 2 | 2347171 |
| Bradycardia | 131.62 | 23.16 | 81 | 10831 | 9900 | 2337273 |
| Cardiac failure congestive | 131.40 | 23.16 | 97 | 10815 | 16004 | 2331169 |
| Anuria | 128.09 | 23.16 | 47 | 10865 | 1777 | 2345396 |
| Arthralgia | 127.99 | 23.16 | 165 | 10747 | 54120 | 2293053 |
| Femoral hernia incarcerated | 126.76 | 23.16 | 21 | 10891 | 8 | 2347165 |
| Somnolence | 126.69 | 23.16 | 111 | 10801 | 23374 | 2323799 |
| Left ventricular dysfunction | 125.69 | 23.16 | 42 | 10870 | 1198 | 2345975 |
| Blood sodium decreased | 123.37 | 23.16 | 53 | 10859 | 3047 | 2344126 |
| Interstitial lung disease | 122.79 | 23.16 | 71 | 10841 | 7741 | 2339432 |
| Gamma-glutamyltransferase increased | 121.93 | 23.16 | 63 | 10849 | 5499 | 2341674 |
| Blood potassium decreased | 121.83 | 23.16 | 62 | 10850 | 5243 | 2341930 |
| Pyrexia | 121.55 | 23.16 | 160 | 10752 | 53548 | 2293625 |
| Tricuspid valve incompetence | 121.22 | 23.16 | 44 | 10868 | 1612 | 2345561 |
| Back pain | 119.89 | 23.16 | 123 | 10789 | 31536 | 2315637 |
| Pancreatic steatosis | 119.76 | 23.16 | 22 | 10890 | 33 | 2347140 |
| Swelling | 112.51 | 23.16 | 89 | 10823 | 16261 | 2330912 |
| Abdominal pain upper | 110.33 | 23.16 | 100 | 10812 | 22000 | 2325173 |
| Coronary artery disease | 109.66 | 23.16 | 60 | 10852 | 5879 | 2341294 |
| Cataract | 107.19 | 23.16 | 59 | 10853 | 5849 | 2341324 |
| Hepatic cyst | 106.90 | 23.16 | 32 | 10880 | 631 | 2346542 |
| Erythema | 106.74 | 23.16 | 104 | 10808 | 25055 | 2322118 |
| Abdominal pain | 106.32 | 23.16 | 120 | 10792 | 34254 | 2312919 |
| Stress | 106.23 | 23.16 | 62 | 10850 | 6876 | 2340297 |
| Aspartate aminotransferase increased | 105.17 | 23.16 | 77 | 10835 | 12535 | 2334638 |
| Wound infection pseudomonas | 103.97 | 23.16 | 21 | 10891 | 65 | 2347108 |
| Anxiety | 103.84 | 23.16 | 110 | 10802 | 29249 | 2317924 |
| Dementia Alzheimer's type | 103.32 | 23.16 | 33 | 10879 | 813 | 2346360 |
| Urinary retention | 102.49 | 23.16 | 49 | 10863 | 3618 | 2343555 |
| Arterial haemorrhage | 101.96 | 23.16 | 24 | 10888 | 175 | 2346998 |
| Pollakiuria | 101.37 | 23.16 | 49 | 10863 | 3707 | 2343466 |
| Influenza | 100.97 | 23.16 | 76 | 10836 | 12902 | 2334271 |
| Chronic obstructive pulmonary disease | 99.87 | 23.16 | 60 | 10852 | 7017 | 2340156 |
| Blood cholesterol increased | 99.68 | 23.16 | 54 | 10858 | 5187 | 2341986 |
| Tachyarrhythmia | 99.17 | 23.16 | 30 | 10882 | 614 | 2346559 |
| Depression | 97.00 | 23.16 | 104 | 10808 | 28028 | 2319145 |
| Vision blurred | 96.97 | 23.16 | 78 | 10834 | 14590 | 2332583 |
| Gout | 96.67 | 23.16 | 36 | 10876 | 1419 | 2345754 |
| Aortic arteriosclerosis | 95.52 | 23.16 | 29 | 10883 | 601 | 2346572 |
| Condition aggravated | 94.41 | 23.16 | 109 | 10803 | 31870 | 2315303 |
| Inflammatory marker increased | 93.83 | 23.16 | 28 | 10884 | 546 | 2346627 |
| Aortic valve stenosis | 93.78 | 23.16 | 25 | 10887 | 317 | 2346856 |
| Alanine aminotransferase increased | 93.57 | 23.16 | 75 | 10837 | 13957 | 2333216 |
| Blood creatine phosphokinase increased | 92.37 | 23.16 | 51 | 10861 | 5085 | 2342088 |
| Cardiomegaly | 92.17 | 23.16 | 40 | 10872 | 2356 | 2344817 |
| Drug hypersensitivity | 91.89 | 23.16 | 130 | 10782 | 46513 | 2300660 |
| Tremor | 90.60 | 23.16 | 87 | 10825 | 20574 | 2326599 |
| Hemiplegia | 90.56 | 23.16 | 34 | 10878 | 1371 | 2345802 |
| Hypoacusis | 90.37 | 23.16 | 44 | 10868 | 3381 | 2343792 |
| Arthritis | 90.28 | 23.16 | 64 | 10848 | 9904 | 2337269 |
| Muscular weakness | 89.63 | 23.16 | 75 | 10837 | 14822 | 2332351 |
| Blood alkaline phosphatase increased | 88.51 | 23.16 | 54 | 10858 | 6491 | 2340682 |
| Hypoaesthesia | 88.41 | 23.16 | 85 | 10827 | 20130 | 2327043 |
| Glaucoma | 87.26 | 23.16 | 37 | 10875 | 2058 | 2345115 |
| Blood lactate dehydrogenase increased | 86.68 | 23.16 | 43 | 10869 | 3441 | 2343732 |
| Haematuria | 86.34 | 23.16 | 46 | 10866 | 4272 | 2342901 |
| Pleural effusion | 85.62 | 23.16 | 66 | 10846 | 11602 | 2335571 |
| Dementia | 84.72 | 23.16 | 39 | 10873 | 2642 | 2344531 |
| Weight fluctuation | 84.57 | 23.16 | 27 | 10885 | 664 | 2346509 |
| Speech disorder | 84.02 | 23.16 | 52 | 10860 | 6412 | 2340761 |
| Coma | 83.99 | 23.16 | 59 | 10853 | 8997 | 2338176 |
| Ventricular extrasystoles | 82.81 | 23.16 | 35 | 10877 | 1931 | 2345242 |
| Dysphagia | 82.31 | 23.16 | 67 | 10845 | 12738 | 2334435 |
| Drug interaction | 82.05 | 23.16 | 97 | 10815 | 29066 | 2318107 |
| Dyspepsia | 81.82 | 23.16 | 60 | 10852 | 9784 | 2337389 |
| Blood uric acid increased | 81.61 | 23.16 | 26 | 10886 | 635 | 2346538 |
| Diabetes mellitus inadequate control | 80.84 | 23.16 | 34 | 10878 | 1853 | 2345320 |
| Pulmonary oedema | 80.23 | 23.16 | 53 | 10859 | 7310 | 2339863 |
| Cardiovascular disorder | 79.91 | 23.16 | 36 | 10876 | 2319 | 2344854 |
| Seroma | 79.75 | 23.16 | 21 | 10891 | 253 | 2346920 |
| Haemarthrosis | 79.37 | 23.16 | 23 | 10889 | 403 | 2346770 |
| Infarction | 79.00 | 23.16 | 25 | 10887 | 597 | 2346576 |
| Urticaria | 78.91 | 23.16 | 87 | 10825 | 24174 | 2322999 |
| Glycosylated haemoglobin increased | 78.42 | 23.16 | 33 | 10879 | 1801 | 2345372 |
| Forced expiratory volume decreased | 78.00 | 23.16 | 24 | 10888 | 521 | 2346652 |
| N-terminal prohormone brain natriuretic peptide increased | 77.74 | 23.16 | 18 | 10894 | 121 | 2347052 |
| Faecaloma | 77.13 | 23.16 | 27 | 10885 | 888 | 2346285 |
| Diverticulum intestinal | 76.74 | 23.16 | 25 | 10887 | 657 | 2346516 |
| Pulmonary hypertension | 76.39 | 23.16 | 45 | 10867 | 5073 | 2342100 |
| Fear | 76.29 | 23.16 | 36 | 10876 | 2580 | 2344593 |
| Bronchitis | 76.26 | 23.16 | 66 | 10846 | 13648 | 2333525 |
| Dizziness postural | 76.03 | 23.16 | 27 | 10885 | 927 | 2346246 |
| Balance disorder | 75.62 | 23.16 | 57 | 10855 | 9690 | 2337483 |
| Rhabdomyolysis | 74.85 | 23.16 | 49 | 10863 | 6655 | 2340518 |
| Eructation | 74.46 | 23.16 | 28 | 10884 | 1134 | 2346039 |
| Blood pressure systolic decreased | 74.24 | 23.16 | 25 | 10887 | 730 | 2346443 |
| Neoplasm malignant | 73.98 | 23.16 | 44 | 10868 | 5049 | 2342124 |
| Depressed level of consciousness | 73.93 | 23.16 | 51 | 10861 | 7553 | 2339620 |
| Groin pain | 73.88 | 23.16 | 29 | 10883 | 1321 | 2345852 |
| Hypoglycaemia | 73.87 | 23.16 | 53 | 10859 | 8354 | 2338819 |
| Osteoarthritis | 73.27 | 23.16 | 49 | 10863 | 6897 | 2340276 |
| Transient ischaemic attack | 72.43 | 23.16 | 46 | 10866 | 5932 | 2341241 |
| Brain natriuretic peptide increased | 71.38 | 23.16 | 23 | 10889 | 583 | 2346590 |
| Vertigo | 70.86 | 23.16 | 54 | 10858 | 9330 | 2337843 |
| Maternal exposure during pregnancy | 69.74 | 23.16 | 65 | 10847 | 14798 | 2332375 |
| Heart rate irregular | 69.55 | 23.16 | 33 | 10879 | 2394 | 2344779 |
| Deafness | 69.16 | 23.16 | 34 | 10878 | 2667 | 2344506 |
| Cardiac failure acute | 68.90 | 23.16 | 26 | 10886 | 1063 | 2346110 |
| Product use in unapproved indication | 68.62 | 23.16 | 57 | 10855 | 11143 | 2336030 |
| Wound dehiscence | 68.03 | 23.16 | 23 | 10889 | 680 | 2346493 |
| Gait inability | 67.64 | 23.16 | 44 | 10868 | 5911 | 2341262 |
| Lower respiratory tract infection | 66.37 | 23.16 | 42 | 10870 | 5382 | 2341791 |
| Thrombotic stroke | 66.23 | 23.16 | 16 | 10896 | 132 | 2347041 |
| Suicide attempt | 66.19 | 23.16 | 56 | 10856 | 11226 | 2335947 |
| Tinnitus | 65.94 | 23.16 | 41 | 10871 | 5094 | 2342079 |
| Orthopnoea | 65.80 | 23.16 | 22 | 10890 | 628 | 2346545 |
| Urinary incontinence | 65.23 | 23.16 | 38 | 10874 | 4195 | 2342978 |
| Electrocardiogram QRS complex prolonged | 65.01 | 23.16 | 25 | 10887 | 1077 | 2346096 |
| Joint dislocation | 64.94 | 23.16 | 27 | 10885 | 1429 | 2345744 |
| Alopecia | 64.89 | 23.16 | 75 | 10837 | 21926 | 2325247 |
| Circulatory collapse | 64.31 | 23.16 | 36 | 10876 | 3684 | 2343489 |
| Head injury | 64.25 | 23.16 | 37 | 10875 | 3997 | 2343176 |
| Spinal pain | 63.57 | 23.16 | 26 | 10886 | 1319 | 2345854 |
| Dysstasia | 63.56 | 23.16 | 33 | 10879 | 2906 | 2344267 |
| Escherichia infection | 63.52 | 23.16 | 26 | 10886 | 1322 | 2345851 |
| Gastrointestinal haemorrhage | 63.44 | 23.16 | 57 | 10855 | 12378 | 2334795 |
| Total lung capacity increased | 63.37 | 23.16 | 11 | 10901 | 9 | 2347164 |
| Agitation | 63.09 | 23.16 | 54 | 10858 | 10997 | 2336176 |
| Joint swelling | 62.95 | 23.16 | 65 | 10847 | 16754 | 2330419 |
| Gastroenteritis | 62.30 | 23.16 | 33 | 10879 | 3027 | 2344146 |
| Limb discomfort | 61.98 | 23.16 | 34 | 10878 | 3345 | 2343828 |
| Dyspnoea exertional | 61.89 | 23.16 | 41 | 10871 | 5679 | 2341494 |
| Sudden death | 61.73 | 23.16 | 28 | 10884 | 1832 | 2345341 |
| Hyperglycaemia | 60.20 | 23.16 | 38 | 10874 | 4847 | 2342326 |
| Wheezing | 60.13 | 23.16 | 42 | 10870 | 6342 | 2340831 |
| Left ventricular hypertrophy | 60.01 | 23.16 | 21 | 10891 | 690 | 2346483 |
| Visual acuity reduced | 59.82 | 23.16 | 39 | 10873 | 5259 | 2341914 |
| Exposure during pregnancy | 59.81 | 23.16 | 77 | 10835 | 25142 | 2322031 |
| Labile hypertension | 59.24 | 23.16 | 13 | 10899 | 66 | 2347107 |
| Atrioventricular block complete | 58.97 | 23.16 | 25 | 10887 | 1389 | 2345784 |
| Haemoglobin decreased | 58.84 | 23.16 | 65 | 10847 | 18086 | 2329087 |
| Aplastic anaemia | 58.71 | 23.16 | 22 | 10890 | 882 | 2346291 |
| Hypochloraemia | 58.55 | 23.16 | 17 | 10895 | 300 | 2346873 |
| Presyncope | 58.23 | 23.16 | 34 | 10878 | 3769 | 2343404 |
| Toxicity to various agents | 58.18 | 23.16 | 87 | 10825 | 32667 | 2314506 |
| Osteopenia | 57.56 | 23.16 | 27 | 10885 | 1908 | 2345265 |
| Amnesia | 57.55 | 23.16 | 43 | 10869 | 7210 | 2339963 |
| Wound | 57.19 | 23.16 | 30 | 10882 | 2698 | 2344475 |
| Respiratory disorder | 56.61 | 23.16 | 34 | 10878 | 3970 | 2343203 |
| Polyuria | 56.38 | 23.16 | 23 | 10889 | 1159 | 2346014 |
| Device stimulation issue | 56.28 | 23.16 | 9 | 10903 | 1 | 2347172 |
| Apparent death | 56.23 | 23.16 | 17 | 10895 | 347 | 2346826 |
| Cerebral haemorrhage | 56.06 | 23.16 | 38 | 10874 | 5466 | 2341707 |
| Prescribed underdose | 55.93 | 23.16 | 27 | 10885 | 2035 | 2345138 |
| Accident | 55.92 | 23.16 | 21 | 10891 | 847 | 2346326 |
| Incorrect dose administered | 54.57 | 23.16 | 47 | 10865 | 9648 | 2337525 |
| Liver disorder | 53.07 | 23.16 | 39 | 10873 | 6375 | 2340798 |
| Postoperative wound infection | 52.73 | 23.16 | 22 | 10890 | 1174 | 2345999 |
| Hiatus hernia | 52.66 | 23.16 | 26 | 10886 | 2058 | 2345115 |
| Basilar artery occlusion | 52.61 | 23.16 | 10 | 10902 | 20 | 2347153 |
| Hepatic function abnormal | 52.58 | 23.16 | 38 | 10874 | 6054 | 2341119 |
| Gastritis | 52.40 | 23.16 | 34 | 10878 | 4547 | 2342626 |
| Renal artery stenosis | 52.29 | 23.16 | 15 | 10897 | 253 | 2346920 |
| Hip fracture | 51.52 | 23.16 | 34 | 10878 | 4678 | 2342495 |
| Constipation | 51.21 | 23.16 | 66 | 10846 | 21563 | 2325610 |
| Dysphonia | 51.09 | 23.16 | 38 | 10874 | 6326 | 2340847 |
| Movement disorder | 50.61 | 23.16 | 28 | 10884 | 2800 | 2344373 |
| Product dispensing error | 50.59 | 23.16 | 27 | 10885 | 2514 | 2344659 |
| Rales | 50.49 | 23.16 | 21 | 10891 | 1112 | 2346061 |
| Productive cough | 50.10 | 23.16 | 35 | 10877 | 5286 | 2341887 |
| Gastrointestinal disorder | 49.72 | 23.16 | 43 | 10869 | 8874 | 2338299 |
| Hyperhidrosis | 49.58 | 23.16 | 55 | 10857 | 15367 | 2331806 |
| Face oedema | 49.37 | 23.16 | 31 | 10881 | 3917 | 2343256 |
| Fibromyalgia | 49.20 | 23.16 | 29 | 10883 | 3271 | 2343902 |
| Dysarthria | 49.19 | 23.16 | 37 | 10875 | 6265 | 2340908 |
| Paraesthesia | 48.58 | 23.16 | 65 | 10847 | 22023 | 2325150 |
| Intentional overdose | 48.32 | 23.16 | 47 | 10865 | 11274 | 2335899 |
| Low density lipoprotein increased | 48.24 | 23.16 | 21 | 10891 | 1245 | 2345928 |
| Recalled product administered | 48.04 | 23.16 | 9 | 10903 | 16 | 2347157 |
| Pulmonary hypoplasia | 48.02 | 23.16 | 11 | 10901 | 70 | 2347103 |
| Abdominal distension | 47.80 | 23.16 | 45 | 10867 | 10366 | 2336807 |
| Altered state of consciousness | 47.49 | 23.16 | 30 | 10882 | 3830 | 2343343 |
| Eczema | 47.35 | 23.16 | 28 | 10884 | 3177 | 2343996 |
| Electrocardiogram abnormal | 46.98 | 23.16 | 21 | 10891 | 1327 | 2345846 |
| Blood glucose decreased | 46.97 | 23.16 | 28 | 10884 | 3224 | 2343949 |
| Thyroid disorder | 46.95 | 23.16 | 22 | 10890 | 1551 | 2345622 |
| Thrombosis | 46.80 | 23.16 | 42 | 10870 | 9102 | 2338071 |
| Lacunar infarction | 46.63 | 23.16 | 17 | 10895 | 630 | 2346543 |
| Disorientation | 46.63 | 23.16 | 36 | 10876 | 6336 | 2340837 |
| Obstructive airways disorder | 46.61 | 23.16 | 21 | 10891 | 1352 | 2345821 |
| Lethargy | 46.47 | 23.16 | 41 | 10871 | 8689 | 2338484 |
| Bundle branch block left | 46.43 | 23.16 | 19 | 10893 | 965 | 2346208 |
| Dry mouth | 46.43 | 23.16 | 40 | 10872 | 8213 | 2338960 |
| Generalised oedema | 46.35 | 23.16 | 25 | 10887 | 2378 | 2344795 |
| Drug-induced liver injury | 46.14 | 23.16 | 29 | 10883 | 3670 | 2343503 |
| Cardiac arrest | 45.86 | 23.16 | 52 | 10860 | 14878 | 2332295 |
| Atrioventricular block | 45.77 | 23.16 | 20 | 10892 | 1197 | 2345976 |
| Sinus node dysfunction | 45.47 | 23.16 | 17 | 10895 | 677 | 2346496 |
| Throat irritation | 44.84 | 23.16 | 32 | 10880 | 4998 | 2342175 |
| Respiratory failure | 44.79 | 23.16 | 49 | 10863 | 13479 | 2333694 |
| Dysuria | 44.46 | 23.16 | 29 | 10883 | 3912 | 2343261 |
| Surgery | 44.32 | 23.16 | 33 | 10879 | 5502 | 2341671 |
| Discomfort | 44.11 | 23.16 | 32 | 10880 | 5127 | 2342046 |
| Cardiac pacemaker insertion | 44.10 | 23.16 | 17 | 10895 | 737 | 2346436 |
| Eye swelling | 43.97 | 23.16 | 30 | 10882 | 4360 | 2342813 |
| Lower limb fracture | 43.95 | 23.16 | 23 | 10889 | 2058 | 2345115 |
| Underdose | 43.73 | 23.16 | 34 | 10878 | 6044 | 2341129 |
| Foetal exposure during pregnancy | 43.60 | 23.16 | 32 | 10880 | 5220 | 2341953 |
| Breast pain | 43.48 | 23.16 | 20 | 10892 | 1351 | 2345822 |
| Sleep apnoea syndrome | 43.48 | 23.16 | 23 | 10889 | 2103 | 2345070 |
| White blood cell count increased | 43.29 | 23.16 | 36 | 10876 | 7042 | 2340131 |
| Head discomfort | 42.91 | 23.16 | 21 | 10891 | 1630 | 2345543 |
| Arterial occlusive disease | 42.61 | 23.16 | 16 | 10896 | 645 | 2346528 |
| Nephropathy | 42.51 | 23.16 | 17 | 10895 | 813 | 2346360 |
| Hepatitis | 42.48 | 23.16 | 34 | 10878 | 6303 | 2340870 |
| Frustration tolerance decreased | 42.45 | 23.16 | 17 | 10895 | 816 | 2346357 |
| Myocardial ischaemia | 42.14 | 23.16 | 23 | 10889 | 2239 | 2344934 |
| Seizure | 42.02 | 23.16 | 64 | 10848 | 24402 | 2322771 |
| Metabolic acidosis | 41.96 | 23.16 | 33 | 10879 | 5965 | 2341208 |
| Arteriosclerosis | 41.92 | 23.16 | 20 | 10892 | 1468 | 2345705 |
| Acute pulmonary oedema | 41.87 | 23.16 | 19 | 10893 | 1244 | 2345929 |
| Urine output decreased | 41.53 | 23.16 | 20 | 10892 | 1499 | 2345674 |
| Choking | 41.29 | 23.16 | 20 | 10892 | 1518 | 2345655 |
| Aortic valve incompetence | 41.27 | 23.16 | 17 | 10895 | 878 | 2346295 |
| Creatinine renal clearance decreased | 40.89 | 23.16 | 17 | 10895 | 899 | 2346274 |
| Sinus bradycardia | 40.77 | 23.16 | 22 | 10890 | 2094 | 2345079 |
| Ophthalmic vein thrombosis | 40.30 | 23.16 | 8 | 10904 | 22 | 2347151 |
| Glucose tolerance impaired | 40.25 | 23.16 | 15 | 10897 | 592 | 2346581 |
| Acute myocardial infarction | 40.16 | 23.16 | 30 | 10882 | 5025 | 2342148 |
| Cardiomyopathy | 40.10 | 23.16 | 24 | 10888 | 2783 | 2344390 |
| Product substitution issue | 40.09 | 23.16 | 30 | 10882 | 5039 | 2342134 |
| Limb injury | 39.91 | 23.16 | 23 | 10889 | 2487 | 2344686 |
| Sleep disorder | 39.68 | 23.16 | 33 | 10879 | 6456 | 2340717 |
| Myelodysplastic syndrome | 39.49 | 23.16 | 23 | 10889 | 2537 | 2344636 |
| Depressed mood | 39.42 | 23.16 | 30 | 10882 | 5168 | 2342005 |
| Blindness | 39.29 | 23.16 | 26 | 10886 | 3592 | 2343581 |
| Eating disorder | 39.22 | 23.16 | 22 | 10890 | 2259 | 2344914 |
| General physical condition abnormal | 38.68 | 23.16 | 15 | 10897 | 661 | 2346512 |
| Cholelithiasis | 38.61 | 23.16 | 31 | 10881 | 5772 | 2341401 |
| Impaired healing | 38.35 | 23.16 | 30 | 10882 | 5381 | 2341792 |
| Ischaemic stroke | 38.32 | 23.16 | 25 | 10887 | 3372 | 2343801 |
| Brain stem stroke | 38.06 | 23.16 | 9 | 10903 | 67 | 2347106 |
| Joint injury | 37.98 | 23.16 | 22 | 10890 | 2402 | 2344771 |
| Parkinson's disease | 37.90 | 23.16 | 18 | 10894 | 1308 | 2345865 |
| Paralysis | 37.86 | 23.16 | 20 | 10892 | 1824 | 2345349 |
| Haematoma | 37.61 | 23.16 | 29 | 10883 | 5092 | 2342081 |
| Road traffic accident | 37.46 | 23.16 | 27 | 10885 | 4281 | 2342892 |
| Pulmonary thrombosis | 37.40 | 23.16 | 17 | 10895 | 1117 | 2346056 |
| Thrombocytopenia | 37.10 | 23.16 | 53 | 10859 | 19078 | 2328095 |
| Pulmonary congestion | 36.66 | 23.16 | 20 | 10892 | 1945 | 2345228 |
| Hyperuricaemia | 36.65 | 23.16 | 14 | 10898 | 592 | 2346581 |
| Lactic acidosis | 36.59 | 23.16 | 29 | 10883 | 5301 | 2341872 |
| Aphasia | 36.40 | 23.16 | 28 | 10884 | 4900 | 2342273 |
| Atrial flutter | 36.25 | 23.16 | 17 | 10895 | 1200 | 2345973 |
| Macular degeneration | 36.17 | 23.16 | 17 | 10895 | 1206 | 2345967 |
| Oral pain | 35.90 | 23.16 | 24 | 10888 | 3373 | 2343800 |
| Product colour issue | 35.86 | 23.16 | 11 | 10901 | 236 | 2346937 |
| Intervertebral disc protrusion | 35.83 | 23.16 | 23 | 10889 | 3018 | 2344155 |
| Premature labour | 35.37 | 23.16 | 20 | 10892 | 2086 | 2345087 |
| Labyrinthitis | 35.32 | 23.16 | 12 | 10900 | 360 | 2346813 |
| Haematocrit decreased | 35.14 | 23.16 | 26 | 10886 | 4292 | 2342881 |
| Product odour abnormal | 35.10 | 23.16 | 12 | 10900 | 367 | 2346806 |
| Musculoskeletal discomfort | 35.08 | 23.16 | 20 | 10892 | 2118 | 2345055 |
| Renal cancer | 35.00 | 23.16 | 14 | 10898 | 670 | 2346503 |
| Inflammation | 34.71 | 23.16 | 30 | 10882 | 6183 | 2340990 |
| Eye disorder | 34.64 | 23.16 | 23 | 10889 | 3196 | 2343977 |
| Osteoporosis | 34.63 | 23.16 | 26 | 10886 | 4388 | 2342785 |
| Blood bilirubin increased | 34.39 | 23.16 | 28 | 10884 | 5317 | 2341856 |
| Eosinophil count increased | 34.27 | 23.16 | 16 | 10896 | 1118 | 2346055 |
| Left ventricular failure | 34.19 | 23.16 | 14 | 10898 | 712 | 2346461 |
| Sepsis | 34.08 | 23.16 | 50 | 10862 | 18438 | 2328735 |
| Cholestasis | 33.92 | 23.16 | 24 | 10888 | 3697 | 2343476 |
| Infection | 33.58 | 23.16 | 49 | 10863 | 17980 | 2329193 |
| Hypovolaemia | 33.37 | 23.16 | 16 | 10896 | 1187 | 2345986 |
| Diabetic nephropathy | 32.72 | 23.16 | 10 | 10902 | 212 | 2346961 |
| Coronary artery stenosis | 32.53 | 23.16 | 14 | 10898 | 807 | 2346366 |
| Lipoedema | 32.50 | 23.16 | 7 | 10905 | 32 | 2347141 |
| Respiration abnormal | 32.48 | 23.16 | 13 | 10899 | 623 | 2346550 |
| Bladder spasm | 32.07 | 23.16 | 10 | 10902 | 227 | 2346946 |
| Ventricular fibrillation | 31.91 | 23.16 | 19 | 10893 | 2182 | 2344991 |
| Heart valve incompetence | 31.70 | 23.16 | 11 | 10901 | 352 | 2346821 |
| Hypercholesterolaemia | 31.67 | 23.16 | 17 | 10895 | 1601 | 2345572 |
| Lymphocyte stimulation test positive | 31.67 | 23.16 | 10 | 10902 | 237 | 2346936 |
| Gastric cancer | 31.55 | 23.16 | 13 | 10899 | 672 | 2346501 |
| Distributive shock | 31.21 | 23.16 | 8 | 10904 | 86 | 2347087 |
| Inappropriate antidiuretic hormone secretion | 31.07 | 23.16 | 19 | 10893 | 2290 | 2344883 |
| Platelet count decreased | 30.94 | 23.16 | 44 | 10868 | 15769 | 2331404 |
| Cardiac valve disease | 30.82 | 23.16 | 13 | 10899 | 713 | 2346460 |
| Sputum discoloured | 30.81 | 23.16 | 15 | 10897 | 1151 | 2346022 |
| Delirium | 30.77 | 23.16 | 26 | 10886 | 5197 | 2341976 |
| Normochromic normocytic anaemia | 30.72 | 23.16 | 13 | 10899 | 719 | 2346454 |
| Pharyngeal oedema | 30.62 | 23.16 | 22 | 10890 | 3471 | 2343702 |
| Hypokinesia | 30.38 | 23.16 | 17 | 10895 | 1737 | 2345436 |
| Facial paralysis | 30.26 | 23.16 | 19 | 10893 | 2400 | 2344773 |
| Anal incontinence | 30.22 | 23.16 | 17 | 10895 | 1755 | 2345418 |
| Cardio-respiratory arrest | 30.04 | 23.16 | 33 | 10879 | 9113 | 2338060 |
| Hepatic steatosis | 29.93 | 23.16 | 21 | 10891 | 3192 | 2343981 |
| Purpura | 29.88 | 23.16 | 17 | 10895 | 1793 | 2345380 |
| Cardiac myxoma | 29.86 | 23.16 | 7 | 10905 | 50 | 2347123 |
| Hepatic enzyme increased | 29.86 | 23.16 | 34 | 10878 | 9768 | 2337405 |
| Proteinuria | 29.79 | 23.16 | 20 | 10892 | 2830 | 2344343 |
| Malabsorption | 29.61 | 23.16 | 12 | 10900 | 594 | 2346579 |
| Normochromic anaemia | 29.60 | 23.16 | 6 | 10906 | 19 | 2347154 |
| Jaundice | 29.57 | 23.16 | 26 | 10886 | 5482 | 2341691 |
| Ejection fraction abnormal | 29.54 | 23.16 | 8 | 10904 | 108 | 2347065 |
| Sinus arrest | 29.47 | 23.16 | 10 | 10902 | 299 | 2346874 |
| Colon cancer | 29.34 | 23.16 | 17 | 10895 | 1856 | 2345317 |
| Respiratory distress | 29.13 | 23.16 | 25 | 10887 | 5104 | 2342069 |
| Blood sodium increased | 28.77 | 23.16 | 11 | 10901 | 466 | 2346707 |
| Cardiac murmur | 28.59 | 23.16 | 16 | 10896 | 1635 | 2345538 |
| Angina unstable | 28.56 | 23.16 | 15 | 10897 | 1351 | 2345822 |
| Gastrooesophageal reflux disease | 28.47 | 23.16 | 32 | 10880 | 9063 | 2338110 |
| Intracranial aneurysm | 28.33 | 23.16 | 12 | 10900 | 665 | 2346508 |
| Duodenal ulcer | 28.22 | 23.16 | 14 | 10898 | 1119 | 2346054 |
| Carpal tunnel syndrome | 28.11 | 23.16 | 17 | 10895 | 2008 | 2345165 |
| Lymphoedema | 28.08 | 23.16 | 14 | 10898 | 1131 | 2346042 |
| Incontinence | 27.68 | 23.16 | 15 | 10897 | 1439 | 2345734 |
| Spinal osteoarthritis | 27.66 | 23.16 | 16 | 10896 | 1741 | 2345432 |
| Dyslipidaemia | 27.19 | 23.16 | 12 | 10900 | 735 | 2346438 |
| Globulins increased | 27.16 | 23.16 | 7 | 10905 | 77 | 2347096 |
| Product use issue | 27.02 | 23.16 | 36 | 10876 | 12133 | 2335040 |
| Femur fracture | 26.93 | 23.16 | 27 | 10885 | 6712 | 2340461 |
| Lung disorder | 26.89 | 23.16 | 26 | 10886 | 6186 | 2340987 |
| Type 2 diabetes mellitus | 26.86 | 23.16 | 17 | 10895 | 2177 | 2344996 |
| Hypomagnesaemia | 26.82 | 23.16 | 18 | 10894 | 2546 | 2344627 |
| Post procedural complication | 26.80 | 23.16 | 19 | 10893 | 2935 | 2344238 |
| Urinary tract infection enterococcal | 26.75 | 23.16 | 9 | 10903 | 262 | 2346911 |
| Red blood cell count decreased | 26.71 | 23.16 | 22 | 10890 | 4244 | 2342929 |
| Electrocardiogram ST segment depression | 26.65 | 23.16 | 11 | 10901 | 571 | 2346602 |
| Haemorrhage | 26.60 | 23.16 | 34 | 10878 | 11005 | 2336168 |
| Acute coronary syndrome | 26.54 | 23.16 | 15 | 10897 | 1562 | 2345611 |
| Ankle fracture | 26.36 | 23.16 | 17 | 10895 | 2248 | 2344925 |
| Labelled drug-drug interaction medication error | 26.32 | 23.16 | 14 | 10898 | 1294 | 2345879 |
| Lung neoplasm malignant | 26.30 | 23.16 | 19 | 10893 | 3023 | 2344150 |
| Renal atrophy | 26.29 | 23.16 | 8 | 10904 | 167 | 2347006 |
| Pancreatitis | 26.27 | 23.16 | 29 | 10883 | 8050 | 2339123 |
| Red cell distribution width increased | 26.27 | 23.16 | 11 | 10901 | 592 | 2346581 |
| Azotaemia | 26.24 | 23.16 | 11 | 10901 | 594 | 2346579 |
| Agranulocytosis | 26.19 | 23.16 | 20 | 10892 | 3462 | 2343711 |
| Paraesthesia oral | 26.16 | 23.16 | 17 | 10895 | 2277 | 2344896 |
| Oxygen saturation decreased | 26.01 | 23.16 | 28 | 10884 | 7558 | 2339615 |
| Concomitant disease progression | 25.90 | 23.16 | 10 | 10902 | 435 | 2346738 |
| Upper limb fracture | 25.83 | 23.16 | 18 | 10894 | 2705 | 2344468 |
| Shock | 25.81 | 23.16 | 21 | 10891 | 3983 | 2343190 |
| Fracture | 25.79 | 23.16 | 18 | 10894 | 2713 | 2344460 |
| Contusion | 25.58 | 23.16 | 36 | 10876 | 12774 | 2334399 |
| Skin irritation | 25.57 | 23.16 | 14 | 10898 | 1371 | 2345802 |
| Endometrial cancer | 25.53 | 23.16 | 11 | 10901 | 636 | 2346537 |
| Premature baby | 25.42 | 23.16 | 19 | 10893 | 3185 | 2343988 |
| Electrocardiogram QT prolonged | 25.33 | 23.16 | 28 | 10884 | 7786 | 2339387 |
| Foetal growth restriction | 25.22 | 23.16 | 13 | 10899 | 1127 | 2346046 |
| Nocturia | 25.18 | 23.16 | 12 | 10900 | 878 | 2346295 |
| Stevens-Johnson syndrome | 24.67 | 23.16 | 21 | 10891 | 4238 | 2342935 |
| Blood chloride decreased | 24.60 | 23.16 | 11 | 10901 | 695 | 2346478 |
| Catheterisation cardiac | 24.56 | 23.16 | 11 | 10901 | 698 | 2346475 |
| Feeling hot | 24.51 | 23.16 | 26 | 10886 | 6902 | 2340271 |
| Angioplasty | 24.42 | 23.16 | 8 | 10904 | 214 | 2346959 |
| Rib fracture | 24.32 | 23.16 | 17 | 10895 | 2568 | 2344605 |
| Ventricular tachycardia | 24.21 | 23.16 | 18 | 10894 | 2993 | 2344180 |
| Body height decreased | 24.18 | 23.16 | 13 | 10899 | 1228 | 2345945 |
| Hemiparesis | 24.17 | 23.16 | 19 | 10893 | 3431 | 2343742 |
| Completed suicide | 24.13 | 23.16 | 46 | 10866 | 20988 | 2326185 |
| Multiple organ dysfunction syndrome | 24.11 | 23.16 | 27 | 10885 | 7614 | 2339559 |
| Eye pain | 24.10 | 23.16 | 22 | 10890 | 4869 | 2342304 |
| Eyelid oedema | 24.08 | 23.16 | 17 | 10895 | 2609 | 2344564 |
| Neck pain | 23.95 | 23.16 | 27 | 10885 | 7670 | 2339503 |
| Pulmonary embolism | 23.85 | 23.16 | 42 | 10870 | 18041 | 2329132 |
| Heart rate abnormal | 23.84 | 23.16 | 10 | 10902 | 541 | 2346632 |
| Hypophagia | 23.74 | 23.16 | 20 | 10892 | 3980 | 2343193 |
| Myelopathy | 23.73 | 23.16 | 9 | 10903 | 373 | 2346800 |
| Varicose vein | 23.70 | 23.16 | 11 | 10901 | 758 | 2346415 |
| Skin lesion | 23.63 | 23.16 | 20 | 10892 | 4005 | 2343168 |
| Blood glucose abnormal | 23.63 | 23.16 | 13 | 10899 | 1285 | 2345888 |
| Acidosis | 23.61 | 23.16 | 14 | 10898 | 1596 | 2345577 |
| Therapeutic drug monitoring analysis not performed | 23.56 | 23.16 | 5 | 10907 | 21 | 2347152 |
| Pigmentation disorder | 23.54 | 23.16 | 11 | 10901 | 770 | 2346403 |
| Thrombophlebitis | 23.44 | 23.16 | 11 | 10901 | 778 | 2346395 |
| Overdose | 23.42 | 23.16 | 44 | 10868 | 19863 | 2327310 |
| Ascites | 23.35 | 23.16 | 23 | 10889 | 5597 | 2341576 |
| Arthropathy | 23.34 | 23.16 | 26 | 10886 | 7290 | 2339883 |
| Faeces discoloured | 23.33 | 23.16 | 16 | 10896 | 2343 | 2344830 |
| Skin disorder | 23.31 | 23.16 | 19 | 10893 | 3612 | 2343561 |
| Dyspnoea at rest | 23.30 | 23.16 | 9 | 10903 | 392 | 2346781 |
| Flushing | 23.17 | 23.16 | 33 | 10879 | 11838 | 2335335 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypotension | 4254.95 | 31.69 | 1576 | 13142 | 28078 | 1703985 |
| Dizziness | 2080.05 | 31.69 | 994 | 13724 | 33367 | 1698696 |
| Cardiac failure | 1906.60 | 31.69 | 702 | 14016 | 11900 | 1720163 |
| Dyspnoea | 1574.62 | 31.69 | 950 | 13768 | 51109 | 1680954 |
| Blood creatinine increased | 1293.21 | 31.69 | 546 | 14172 | 13400 | 1718663 |
| Hyperkalaemia | 1064.12 | 31.69 | 414 | 14304 | 8133 | 1723930 |
| Acute kidney injury | 1028.51 | 31.69 | 629 | 14089 | 34315 | 1697748 |
| Blood pressure decreased | 1025.33 | 31.69 | 391 | 14327 | 7255 | 1724808 |
| Fatigue | 918.11 | 31.69 | 675 | 14043 | 50106 | 1681957 |
| Death | 912.30 | 31.69 | 843 | 13875 | 86600 | 1645463 |
| Cough | 875.54 | 31.69 | 461 | 14257 | 18736 | 1713327 |
| Renal failure | 779.49 | 31.69 | 433 | 14285 | 19584 | 1712479 |
| Blood pressure increased | 705.28 | 31.69 | 331 | 14387 | 10422 | 1721641 |
| Malaise | 676.29 | 31.69 | 455 | 14263 | 29110 | 1702953 |
| Blood potassium increased | 653.04 | 31.69 | 211 | 14507 | 2319 | 1729744 |
| Renal impairment | 650.77 | 31.69 | 327 | 14391 | 11987 | 1720076 |
| Syncope | 647.08 | 31.69 | 341 | 14377 | 13828 | 1718235 |
| Angioedema | 616.65 | 31.69 | 292 | 14426 | 9372 | 1722691 |
| Hypertension | 600.28 | 31.69 | 362 | 14356 | 19086 | 1712977 |
| Weight increased | 598.23 | 31.69 | 301 | 14417 | 11056 | 1721007 |
| Asthenia | 533.56 | 31.69 | 420 | 14298 | 34250 | 1697813 |
| Wrong technique in product usage process | 504.64 | 31.69 | 262 | 14456 | 10273 | 1721790 |
| Contraindicated product administered | 483.51 | 31.69 | 147 | 14571 | 1297 | 1730766 |
| Fall | 475.96 | 31.69 | 356 | 14362 | 26858 | 1705205 |
| Ejection fraction decreased | 470.23 | 31.69 | 160 | 14558 | 2085 | 1729978 |
| No adverse event | 468.72 | 31.69 | 200 | 14518 | 4982 | 1727081 |
| Blood urea increased | 463.38 | 31.69 | 193 | 14525 | 4518 | 1727545 |
| Product prescribing error | 436.11 | 31.69 | 154 | 14564 | 2256 | 1729807 |
| Oedema peripheral | 404.68 | 31.69 | 260 | 14458 | 15290 | 1716773 |
| Weight decreased | 398.26 | 31.69 | 298 | 14420 | 22455 | 1709608 |
| Inappropriate schedule of product administration | 387.32 | 31.69 | 196 | 14522 | 7263 | 1724800 |
| Pruritus | 373.02 | 31.69 | 289 | 14429 | 22933 | 1709130 |
| Chest pain | 371.27 | 31.69 | 271 | 14447 | 19643 | 1712420 |
| Atrial fibrillation | 364.57 | 31.69 | 241 | 14477 | 14870 | 1717193 |
| Feeling abnormal | 351.89 | 31.69 | 211 | 14507 | 10955 | 1721108 |
| Fluid retention | 344.26 | 31.69 | 147 | 14571 | 3662 | 1728401 |
| Loss of consciousness | 334.19 | 31.69 | 227 | 14491 | 14648 | 1717415 |
| Cardiac failure chronic | 332.68 | 31.69 | 92 | 14626 | 556 | 1731507 |
| Blood pressure inadequately controlled | 328.43 | 31.69 | 90 | 14628 | 523 | 1731540 |
| Diarrhoea | 326.26 | 31.69 | 391 | 14327 | 53461 | 1678602 |
| Blood glucose increased | 320.55 | 31.69 | 195 | 14523 | 10389 | 1721674 |
| Oedema | 304.51 | 31.69 | 163 | 14555 | 6785 | 1725278 |
| Prescribed underdose | 298.23 | 31.69 | 103 | 14615 | 1405 | 1730658 |
| Cerebrovascular accident | 292.39 | 31.69 | 225 | 14493 | 17641 | 1714422 |
| Peripheral swelling | 283.56 | 31.69 | 163 | 14555 | 7808 | 1724255 |
| Myocardial infarction | 283.54 | 31.69 | 264 | 14454 | 26910 | 1705153 |
| Blood pressure systolic decreased | 281.59 | 31.69 | 82 | 14636 | 612 | 1731451 |
| Ventricular tachycardia | 273.53 | 31.69 | 125 | 14593 | 3673 | 1728390 |
| Glomerular filtration rate decreased | 270.72 | 31.69 | 95 | 14623 | 1362 | 1730701 |
| Hyponatraemia | 270.34 | 31.69 | 165 | 14553 | 8835 | 1723228 |
| Diabetes mellitus | 261.11 | 31.69 | 147 | 14571 | 6761 | 1725302 |
| Rash | 248.79 | 31.69 | 290 | 14428 | 38403 | 1693660 |
| Hypoacusis | 247.05 | 31.69 | 103 | 14615 | 2410 | 1729653 |
| Blood pressure fluctuation | 245.50 | 31.69 | 86 | 14632 | 1226 | 1730837 |
| Orthostatic hypotension | 237.90 | 31.69 | 110 | 14608 | 3321 | 1728742 |
| Dehydration | 224.53 | 31.69 | 192 | 14526 | 17466 | 1714597 |
| Cardiogenic shock | 222.60 | 31.69 | 95 | 14623 | 2359 | 1729704 |
| Drug ineffective | 220.90 | 31.69 | 354 | 14364 | 63447 | 1668616 |
| Arrhythmia | 219.17 | 31.69 | 125 | 14593 | 5891 | 1726172 |
| Pulmonary oedema | 219.12 | 31.69 | 129 | 14589 | 6457 | 1725606 |
| Chronic kidney disease | 208.12 | 31.69 | 108 | 14610 | 4209 | 1727854 |
| Gait disturbance | 203.66 | 31.69 | 158 | 14560 | 12512 | 1719551 |
| Angina pectoris | 198.32 | 31.69 | 110 | 14608 | 4908 | 1727155 |
| Cerebral infarction | 197.19 | 31.69 | 111 | 14607 | 5098 | 1726965 |
| Nausea | 194.97 | 31.69 | 297 | 14421 | 50899 | 1681164 |
| Pneumonia | 194.61 | 31.69 | 281 | 14437 | 45901 | 1686162 |
| Heart rate decreased | 194.53 | 31.69 | 90 | 14628 | 2719 | 1729344 |
| Concomitant disease aggravated | 190.80 | 31.69 | 62 | 14656 | 691 | 1731372 |
| Mitral valve incompetence | 185.50 | 31.69 | 78 | 14640 | 1864 | 1730199 |
| Renal disorder | 184.92 | 31.69 | 98 | 14620 | 3988 | 1728075 |
| Cardiac disorder | 183.54 | 31.69 | 122 | 14596 | 7569 | 1724494 |
| Palpitations | 177.02 | 31.69 | 114 | 14604 | 6700 | 1725363 |
| C-reactive protein increased | 174.31 | 31.69 | 107 | 14611 | 5778 | 1726285 |
| Cardiac failure acute | 172.93 | 31.69 | 65 | 14653 | 1144 | 1730919 |
| Blood pressure abnormal | 172.27 | 31.69 | 63 | 14655 | 1023 | 1731040 |
| Haemoglobin decreased | 171.90 | 31.69 | 163 | 14555 | 16951 | 1715112 |
| Cardiac failure congestive | 171.88 | 31.69 | 155 | 14563 | 15115 | 1716948 |
| Lip swelling | 170.33 | 31.69 | 82 | 14636 | 2713 | 1729350 |
| Headache | 165.27 | 31.69 | 223 | 14495 | 34153 | 1697910 |
| Anaemia | 164.84 | 31.69 | 206 | 14512 | 29251 | 1702812 |
| Dizziness postural | 163.93 | 31.69 | 57 | 14661 | 793 | 1731270 |
| Chronic obstructive pulmonary disease | 163.08 | 31.69 | 103 | 14615 | 5850 | 1726213 |
| Blood pressure diastolic decreased | 162.99 | 31.69 | 55 | 14663 | 695 | 1731368 |
| Chest discomfort | 157.53 | 31.69 | 109 | 14609 | 7222 | 1724841 |
| Bradycardia | 155.53 | 31.69 | 125 | 14593 | 10409 | 1721654 |
| Hypokalaemia | 154.21 | 31.69 | 102 | 14616 | 6272 | 1725791 |
| Brain natriuretic peptide increased | 152.77 | 31.69 | 49 | 14669 | 522 | 1731541 |
| Gamma-glutamyltransferase increased | 151.75 | 31.69 | 93 | 14625 | 5005 | 1727058 |
| Swollen tongue | 146.16 | 31.69 | 74 | 14644 | 2734 | 1729329 |
| General physical health deterioration | 145.31 | 31.69 | 132 | 14586 | 12986 | 1719077 |
| Blood creatine phosphokinase increased | 143.44 | 31.69 | 111 | 14607 | 8745 | 1723318 |
| Blood uric acid increased | 143.40 | 31.69 | 54 | 14664 | 955 | 1731108 |
| Sudden death | 142.95 | 31.69 | 74 | 14644 | 2866 | 1729197 |
| Aspartate aminotransferase increased | 140.73 | 31.69 | 119 | 14599 | 10637 | 1721426 |
| Memory impairment | 140.65 | 31.69 | 98 | 14620 | 6565 | 1725498 |
| Insomnia | 139.15 | 31.69 | 142 | 14576 | 16134 | 1715929 |
| Cardiac arrest | 138.04 | 31.69 | 140 | 14578 | 15790 | 1716273 |
| Heart rate increased | 135.66 | 31.69 | 95 | 14623 | 6415 | 1725648 |
| Blood triglycerides increased | 133.81 | 31.69 | 68 | 14650 | 2532 | 1729531 |
| Product use in unapproved indication | 133.14 | 31.69 | 109 | 14609 | 9313 | 1722750 |
| Orthopnoea | 132.46 | 31.69 | 45 | 14673 | 581 | 1731482 |
| Pain in extremity | 129.39 | 31.69 | 145 | 14573 | 18327 | 1713736 |
| Tricuspid valve incompetence | 128.94 | 31.69 | 53 | 14665 | 1193 | 1730870 |
| Gout | 127.62 | 31.69 | 66 | 14652 | 2550 | 1729513 |
| Left ventricular hypertrophy | 126.19 | 31.69 | 47 | 14671 | 805 | 1731258 |
| Dyspnoea exertional | 124.06 | 31.69 | 76 | 14642 | 4085 | 1727978 |
| Pleural effusion | 123.41 | 31.69 | 112 | 14606 | 10998 | 1721065 |
| Alanine aminotransferase increased | 121.40 | 31.69 | 116 | 14602 | 12162 | 1719901 |
| Decreased appetite | 120.92 | 31.69 | 159 | 14559 | 23712 | 1708351 |
| Left ventricular dysfunction | 120.20 | 31.69 | 50 | 14668 | 1161 | 1730902 |
| Blood pressure systolic increased | 119.18 | 31.69 | 55 | 14663 | 1650 | 1730413 |
| Sudden cardiac death | 118.71 | 31.69 | 45 | 14673 | 811 | 1731252 |
| Acute myocardial infarction | 118.51 | 31.69 | 98 | 14620 | 8489 | 1723574 |
| Swelling face | 116.38 | 31.69 | 75 | 14643 | 4408 | 1727655 |
| N-terminal prohormone brain natriuretic peptide increased | 116.18 | 31.69 | 28 | 14690 | 87 | 1731976 |
| Drug intolerance | 116.01 | 31.69 | 84 | 14634 | 5978 | 1726085 |
| Myalgia | 114.95 | 31.69 | 126 | 14592 | 15532 | 1716531 |
| Haematocrit decreased | 114.67 | 31.69 | 73 | 14645 | 4200 | 1727863 |
| Nasopharyngitis | 113.31 | 31.69 | 102 | 14616 | 9908 | 1722155 |
| Somnolence | 113.12 | 31.69 | 129 | 14589 | 16610 | 1715453 |
| Interstitial lung disease | 112.12 | 31.69 | 100 | 14618 | 9596 | 1722467 |
| Blood sodium decreased | 112.02 | 31.69 | 58 | 14660 | 2246 | 1729817 |
| Visual impairment | 111.85 | 31.69 | 83 | 14635 | 6135 | 1725928 |
| Shock | 108.96 | 31.69 | 70 | 14648 | 4091 | 1727972 |
| Weight fluctuation | 103.50 | 31.69 | 35 | 14683 | 445 | 1731618 |
| Type 2 diabetes mellitus | 102.15 | 31.69 | 51 | 14667 | 1827 | 1730236 |
| Balance disorder | 98.79 | 31.69 | 75 | 14643 | 5737 | 1726326 |
| Vomiting | 98.61 | 31.69 | 187 | 14531 | 38128 | 1693935 |
| Blood creatine increased | 98.19 | 31.69 | 38 | 14680 | 726 | 1731337 |
| Glycosylated haemoglobin increased | 95.96 | 31.69 | 49 | 14669 | 1842 | 1730221 |
| Presyncope | 95.34 | 31.69 | 55 | 14663 | 2643 | 1729420 |
| Blood lactate dehydrogenase increased | 94.19 | 31.69 | 61 | 14657 | 3614 | 1728449 |
| Diastolic dysfunction | 93.29 | 31.69 | 33 | 14685 | 484 | 1731579 |
| Joint swelling | 92.88 | 31.69 | 75 | 14643 | 6278 | 1725785 |
| Heart rate irregular | 92.17 | 31.69 | 46 | 14672 | 1646 | 1730417 |
| Blood cholesterol increased | 92.06 | 31.69 | 56 | 14662 | 2970 | 1729093 |
| Underdose | 91.17 | 31.69 | 61 | 14657 | 3819 | 1728244 |
| Pollakiuria | 90.86 | 31.69 | 55 | 14663 | 2891 | 1729172 |
| Productive cough | 90.55 | 31.69 | 59 | 14659 | 3532 | 1728531 |
| Metabolic acidosis | 90.24 | 31.69 | 69 | 14649 | 5333 | 1726730 |
| Neoplasm malignant | 89.62 | 31.69 | 63 | 14655 | 4276 | 1727787 |
| Back pain | 87.70 | 31.69 | 113 | 14605 | 16500 | 1715563 |
| Device malfunction | 87.19 | 31.69 | 47 | 14671 | 1977 | 1730086 |
| Muscular weakness | 86.75 | 31.69 | 89 | 14629 | 10160 | 1721903 |
| Red blood cell count decreased | 86.72 | 31.69 | 58 | 14660 | 3628 | 1728435 |
| Vertigo | 86.36 | 31.69 | 62 | 14656 | 4351 | 1727712 |
| Ventricular extrasystoles | 86.32 | 31.69 | 46 | 14672 | 1890 | 1730173 |
| Hypoaesthesia | 86.15 | 31.69 | 87 | 14631 | 9748 | 1722315 |
| Cardiorenal syndrome | 85.78 | 31.69 | 21 | 14697 | 71 | 1731992 |
| Eosinophil count increased | 85.02 | 31.69 | 41 | 14677 | 1360 | 1730703 |
| Hypertensive crisis | 84.62 | 31.69 | 42 | 14676 | 1485 | 1730578 |
| Therapeutic response unexpected | 84.55 | 31.69 | 49 | 14669 | 2375 | 1729688 |
| Left atrial enlargement | 84.44 | 31.69 | 19 | 14699 | 39 | 1732024 |
| Acute pulmonary oedema | 84.24 | 31.69 | 39 | 14679 | 1178 | 1730885 |
| Ventricular fibrillation | 83.83 | 31.69 | 51 | 14667 | 2705 | 1729358 |
| Hemiplegia | 83.61 | 31.69 | 40 | 14678 | 1303 | 1730760 |
| Left ventricular dilatation | 81.71 | 31.69 | 19 | 14699 | 48 | 1732015 |
| Nephrogenic anaemia | 81.47 | 31.69 | 24 | 14694 | 187 | 1731876 |
| Hypertensive heart disease | 81.38 | 31.69 | 29 | 14689 | 435 | 1731628 |
| Cardiomegaly | 80.93 | 31.69 | 47 | 14671 | 2287 | 1729776 |
| Muscle spasms | 79.21 | 31.69 | 90 | 14628 | 11531 | 1720532 |
| Hypochromasia | 78.73 | 31.69 | 17 | 14701 | 26 | 1732037 |
| White blood cell count increased | 77.81 | 31.69 | 72 | 14646 | 7240 | 1724823 |
| Patent ductus arteriosus | 77.52 | 31.69 | 31 | 14687 | 648 | 1731415 |
| Urine output decreased | 77.49 | 31.69 | 39 | 14679 | 1421 | 1730642 |
| Urticaria | 77.06 | 31.69 | 91 | 14627 | 12150 | 1719913 |
| Swelling | 76.61 | 31.69 | 70 | 14648 | 6926 | 1725137 |
| Vision blurred | 76.50 | 31.69 | 76 | 14642 | 8347 | 1723716 |
| Hypoglycaemia | 76.39 | 31.69 | 76 | 14642 | 8362 | 1723701 |
| Arthralgia | 75.10 | 31.69 | 126 | 14592 | 23318 | 1708745 |
| Platelet count decreased | 74.37 | 31.69 | 104 | 14614 | 16419 | 1715644 |
| Brain natriuretic peptide abnormal | 74.01 | 31.69 | 15 | 14703 | 13 | 1732050 |
| Blood potassium decreased | 73.76 | 31.69 | 44 | 14674 | 2251 | 1729812 |
| Hyperglycaemia | 73.43 | 31.69 | 60 | 14658 | 5105 | 1726958 |
| Confusional state | 73.06 | 31.69 | 118 | 14600 | 21160 | 1710903 |
| Rhabdomyolysis | 72.39 | 31.69 | 84 | 14634 | 11006 | 1721057 |
| Pain | 72.10 | 31.69 | 133 | 14585 | 26524 | 1705539 |
| Hypervolaemia | 71.03 | 31.69 | 20 | 14698 | 130 | 1731933 |
| Abdominal pain | 70.83 | 31.69 | 117 | 14601 | 21373 | 1710690 |
| Left ventricular enlargement | 70.10 | 31.69 | 16 | 14702 | 36 | 1732027 |
| Abdominal pain upper | 69.60 | 31.69 | 82 | 14636 | 10919 | 1721144 |
| Depression | 69.26 | 31.69 | 101 | 14617 | 16568 | 1715495 |
| Apparent death | 69.14 | 31.69 | 23 | 14695 | 277 | 1731786 |
| Hypersensitivity | 67.99 | 31.69 | 79 | 14639 | 10365 | 1721698 |
| Ischaemic cardiomyopathy | 67.89 | 31.69 | 33 | 14685 | 1114 | 1730949 |
| Mitral valve thickening | 66.65 | 31.69 | 13 | 14705 | 7 | 1732056 |
| Ventricular arrhythmia | 66.05 | 31.69 | 28 | 14690 | 682 | 1731381 |
| Ventricular hypokinesia | 65.79 | 31.69 | 28 | 14690 | 689 | 1731374 |
| N-terminal prohormone brain natriuretic peptide abnormal | 65.72 | 31.69 | 12 | 14706 | 1 | 1732062 |
| Lethargy | 65.56 | 31.69 | 65 | 14653 | 7119 | 1724944 |
| Anuria | 65.40 | 31.69 | 38 | 14680 | 1850 | 1730213 |
| Blood alkaline phosphatase increased | 64.87 | 31.69 | 56 | 14662 | 5139 | 1726924 |
| Hepatic function abnormal | 64.55 | 31.69 | 64 | 14654 | 7010 | 1725053 |
| Hyperhidrosis | 64.40 | 31.69 | 84 | 14634 | 12404 | 1719659 |
| Condition aggravated | 64.19 | 31.69 | 111 | 14607 | 21039 | 1711024 |
| Pulmonary hypertension | 64.15 | 31.69 | 43 | 14675 | 2699 | 1729364 |
| Congestive cardiomyopathy | 63.85 | 31.69 | 32 | 14686 | 1155 | 1730908 |
| Ventricular hyperkinesia | 63.76 | 31.69 | 13 | 14705 | 12 | 1732051 |
| Speech disorder | 62.90 | 31.69 | 52 | 14666 | 4496 | 1727567 |
| Prostate cancer | 62.13 | 31.69 | 52 | 14666 | 4574 | 1727489 |
| Mean platelet volume increased | 61.90 | 31.69 | 15 | 14703 | 48 | 1732015 |
| Pharyngeal oedema | 61.89 | 31.69 | 35 | 14683 | 1618 | 1730445 |
| Right atrial enlargement | 61.83 | 31.69 | 13 | 14705 | 16 | 1732047 |
| Cardiomyopathy | 61.62 | 31.69 | 42 | 14676 | 2710 | 1729353 |
| Influenza | 61.33 | 31.69 | 61 | 14657 | 6706 | 1725357 |
| Blood glucose decreased | 60.57 | 31.69 | 39 | 14679 | 2286 | 1729777 |
| Myocardial ischaemia | 60.50 | 31.69 | 44 | 14674 | 3149 | 1728914 |
| Blood chloride increased | 60.05 | 31.69 | 21 | 14697 | 297 | 1731766 |
| Abdominal discomfort | 59.62 | 31.69 | 69 | 14649 | 9012 | 1723051 |
| Tachycardia | 59.08 | 31.69 | 81 | 14637 | 12547 | 1719516 |
| Liver disorder | 58.99 | 31.69 | 55 | 14663 | 5581 | 1726482 |
| Erythema | 58.97 | 31.69 | 86 | 14632 | 14102 | 1717961 |
| Bundle branch block left | 58.79 | 31.69 | 27 | 14691 | 800 | 1731263 |
| Bronchitis | 58.78 | 31.69 | 54 | 14664 | 5378 | 1726685 |
| Sepsis | 55.08 | 31.69 | 99 | 14619 | 19339 | 1712724 |
| Gastric cancer | 54.64 | 31.69 | 28 | 14690 | 1060 | 1731003 |
| Abdominal distension | 54.58 | 31.69 | 56 | 14662 | 6388 | 1725675 |
| Aortic aneurysm | 53.58 | 31.69 | 27 | 14691 | 986 | 1731077 |
| Fractured coccyx | 53.53 | 31.69 | 12 | 14706 | 24 | 1732039 |
| Eczema | 53.29 | 31.69 | 36 | 14682 | 2288 | 1729775 |
| Respiratory failure | 53.28 | 31.69 | 83 | 14635 | 14422 | 1717641 |
| Dementia Alzheimer's type | 53.22 | 31.69 | 23 | 14695 | 588 | 1731475 |
| Circulatory collapse | 52.93 | 31.69 | 42 | 14676 | 3425 | 1728638 |
| Renal artery stenosis | 52.51 | 31.69 | 18 | 14700 | 239 | 1731824 |
| Diabetic nephropathy | 52.24 | 31.69 | 19 | 14699 | 303 | 1731760 |
| Coronary artery disease | 51.96 | 31.69 | 67 | 14651 | 9779 | 1722284 |
| Dementia | 51.76 | 31.69 | 34 | 14684 | 2062 | 1730001 |
| Anxiety | 51.75 | 31.69 | 85 | 14633 | 15442 | 1716621 |
| Arterial occlusive disease | 50.84 | 31.69 | 24 | 14694 | 758 | 1731305 |
| Arteriosclerosis | 50.64 | 31.69 | 32 | 14686 | 1815 | 1730248 |
| Lymphocyte count decreased | 50.29 | 31.69 | 34 | 14684 | 2164 | 1729899 |
| Microalbuminuria | 50.24 | 31.69 | 15 | 14703 | 123 | 1731940 |
| Multiple organ dysfunction syndrome | 48.94 | 31.69 | 63 | 14655 | 9179 | 1722884 |
| Atrial septal defect | 48.81 | 31.69 | 28 | 14690 | 1330 | 1730733 |
| Pulmonary arterial pressure abnormal | 48.74 | 31.69 | 11 | 14707 | 23 | 1732040 |
| Oxygen saturation increased | 48.74 | 31.69 | 11 | 14707 | 23 | 1732040 |
| Dysphagia | 48.73 | 31.69 | 66 | 14652 | 10102 | 1721961 |
| Hyperuricaemia | 48.55 | 31.69 | 25 | 14693 | 956 | 1731107 |
| Aortic valve incompetence | 48.41 | 31.69 | 23 | 14695 | 737 | 1731326 |
| Sprue-like enteropathy | 48.26 | 31.69 | 12 | 14706 | 44 | 1732019 |
| Blood thyroid stimulating hormone abnormal | 47.84 | 31.69 | 12 | 14706 | 46 | 1732017 |
| Jugular vein distension | 47.64 | 31.69 | 14 | 14704 | 108 | 1731955 |
| Polyuria | 47.06 | 31.69 | 27 | 14691 | 1283 | 1730780 |
| Discomfort | 46.95 | 31.69 | 35 | 14683 | 2601 | 1729462 |
| Electrocardiogram QRS complex abnormal | 46.30 | 31.69 | 12 | 14706 | 54 | 1732009 |
| Lactic acidosis | 46.04 | 31.69 | 46 | 14672 | 5083 | 1726980 |
| Drug interaction | 45.99 | 31.69 | 114 | 14604 | 27844 | 1704219 |
| Premature baby | 45.68 | 31.69 | 36 | 14682 | 2906 | 1729157 |
| Disorientation | 45.36 | 31.69 | 47 | 14671 | 5422 | 1726641 |
| Lung neoplasm malignant | 45.32 | 31.69 | 37 | 14681 | 3142 | 1728921 |
| Pyrexia | 45.31 | 31.69 | 157 | 14561 | 46243 | 1685820 |
| High density lipoprotein decreased | 45.27 | 31.69 | 21 | 14697 | 637 | 1731426 |
| Paraesthesia oral | 45.05 | 31.69 | 22 | 14696 | 750 | 1731313 |
| Throat irritation | 44.65 | 31.69 | 29 | 14689 | 1725 | 1730338 |
| Ascites | 44.53 | 31.69 | 47 | 14671 | 5539 | 1726524 |
| Paraesthesia | 44.36 | 31.69 | 64 | 14654 | 10387 | 1721676 |
| Red cell distribution width increased | 44.32 | 31.69 | 18 | 14700 | 392 | 1731671 |
| Extrasystoles | 44.28 | 31.69 | 22 | 14696 | 779 | 1731284 |
| Amnesia | 44.15 | 31.69 | 44 | 14674 | 4847 | 1727216 |
| Peripheral arterial occlusive disease | 44.10 | 31.69 | 22 | 14696 | 786 | 1731277 |
| Dyspnoea paroxysmal nocturnal | 44.07 | 31.69 | 14 | 14704 | 144 | 1731919 |
| Device inappropriate shock delivery | 43.51 | 31.69 | 8 | 14710 | 1 | 1732062 |
| Rales | 43.51 | 31.69 | 23 | 14695 | 929 | 1731134 |
| Gait inability | 43.50 | 31.69 | 37 | 14681 | 3326 | 1728737 |
| Overdose | 43.44 | 31.69 | 82 | 14636 | 16619 | 1715444 |
| Head injury | 42.70 | 31.69 | 35 | 14683 | 2989 | 1729074 |
| Renal function test abnormal | 42.55 | 31.69 | 18 | 14700 | 436 | 1731627 |
| Stress | 42.48 | 31.69 | 33 | 14685 | 2608 | 1729455 |
| Limb discomfort | 42.26 | 31.69 | 26 | 14692 | 1406 | 1730657 |
| Cerebral haemorrhage | 41.70 | 31.69 | 48 | 14670 | 6229 | 1725834 |
| Jaundice | 41.36 | 31.69 | 47 | 14671 | 6015 | 1726048 |
| Weight loss poor | 41.33 | 31.69 | 11 | 14707 | 56 | 1732007 |
| Road traffic accident | 41.20 | 31.69 | 37 | 14681 | 3576 | 1728487 |
| Exercise tolerance decreased | 41.12 | 31.69 | 19 | 14699 | 571 | 1731492 |
| Dyslipidaemia | 40.76 | 31.69 | 21 | 14697 | 804 | 1731259 |
| Dysuria | 40.69 | 31.69 | 37 | 14681 | 3635 | 1728428 |
| Urinary retention | 40.55 | 31.69 | 44 | 14674 | 5351 | 1726712 |
| Wheezing | 40.54 | 31.69 | 39 | 14679 | 4114 | 1727949 |
| Hypovolaemia | 40.43 | 31.69 | 24 | 14694 | 1216 | 1730847 |
| Proteinuria | 40.33 | 31.69 | 33 | 14685 | 2811 | 1729252 |
| Benign prostatic hyperplasia | 40.29 | 31.69 | 25 | 14693 | 1373 | 1730690 |
| Infection | 40.28 | 31.69 | 67 | 14651 | 12293 | 1719770 |
| Infarction | 40.18 | 31.69 | 20 | 14698 | 711 | 1731352 |
| Lymphocyte stimulation test positive | 39.94 | 31.69 | 15 | 14703 | 263 | 1731800 |
| Coronary artery stenosis | 39.88 | 31.69 | 26 | 14692 | 1556 | 1730507 |
| Ejection fraction abnormal | 39.50 | 31.69 | 12 | 14706 | 105 | 1731958 |
| Sinus arrest | 39.41 | 31.69 | 16 | 14702 | 348 | 1731715 |
| Sleep disorder | 39.37 | 31.69 | 38 | 14680 | 4025 | 1728038 |
| Gouty arthritis | 39.28 | 31.69 | 14 | 14704 | 210 | 1731853 |
| Blood bilirubin increased | 38.77 | 31.69 | 46 | 14672 | 6164 | 1725899 |
| Goitre | 38.73 | 31.69 | 15 | 14703 | 287 | 1731776 |
| Blood iron decreased | 38.68 | 31.69 | 18 | 14700 | 550 | 1731513 |
| Dry mouth | 38.68 | 31.69 | 37 | 14681 | 3876 | 1728187 |
| Pseudomonal sepsis | 38.55 | 31.69 | 16 | 14702 | 369 | 1731694 |
| Hypokinesia | 38.41 | 31.69 | 23 | 14695 | 1184 | 1730879 |
| Pulmonary valve stenosis congenital | 38.23 | 31.69 | 10 | 14708 | 47 | 1732016 |
| Fluid overload | 38.20 | 31.69 | 28 | 14690 | 2027 | 1730036 |
| Atrioventricular block | 38.20 | 31.69 | 24 | 14694 | 1347 | 1730716 |
| Cardio-respiratory arrest | 38.11 | 31.69 | 56 | 14662 | 9237 | 1722826 |
| Chromaturia | 38.10 | 31.69 | 31 | 14687 | 2619 | 1729444 |
| Blood phosphorus increased | 38.07 | 31.69 | 16 | 14702 | 381 | 1731682 |
| Large intestine polyp | 37.60 | 31.69 | 21 | 14697 | 947 | 1731116 |
| Atrial flutter | 37.33 | 31.69 | 27 | 14691 | 1915 | 1730148 |
| Pancreatitis acute | 37.31 | 31.69 | 37 | 14681 | 4050 | 1728013 |
| Cold sweat | 37.29 | 31.69 | 26 | 14692 | 1740 | 1730323 |
| Pallor | 37.07 | 31.69 | 34 | 14684 | 3377 | 1728686 |
| Hepatocellular injury | 36.67 | 31.69 | 33 | 14685 | 3198 | 1728865 |
| Hepatic enzyme increased | 36.41 | 31.69 | 46 | 14672 | 6575 | 1725488 |
| Gastritis | 35.70 | 31.69 | 32 | 14686 | 3085 | 1728978 |
| Cell marker increased | 35.66 | 31.69 | 12 | 14706 | 150 | 1731913 |
| Electrocardiogram T wave inversion | 35.57 | 31.69 | 16 | 14702 | 451 | 1731612 |
| Obstructive airways disorder | 35.57 | 31.69 | 21 | 14697 | 1053 | 1731010 |
| Drug eruption | 35.42 | 31.69 | 31 | 14687 | 2895 | 1729168 |
| Superinfection | 35.16 | 31.69 | 14 | 14704 | 289 | 1731774 |
| Cerebral ischaemia | 35.14 | 31.69 | 21 | 14697 | 1077 | 1730986 |
| Sluggishness | 35.01 | 31.69 | 18 | 14700 | 686 | 1731377 |
| Deafness | 34.78 | 31.69 | 26 | 14692 | 1940 | 1730123 |
| Conduction disorder | 34.72 | 31.69 | 15 | 14703 | 383 | 1731680 |
| Dyspnoea at rest | 34.42 | 31.69 | 14 | 14704 | 306 | 1731757 |
| Gastrointestinal disorder | 34.42 | 31.69 | 38 | 14680 | 4710 | 1727353 |
| Pulmonary hypoplasia | 34.38 | 31.69 | 11 | 14707 | 116 | 1731947 |
| Urinary tract infection | 34.38 | 31.69 | 56 | 14662 | 10097 | 1721966 |
| Pemphigoid | 34.29 | 31.69 | 21 | 14697 | 1126 | 1730937 |
| Product substitution issue | 34.25 | 31.69 | 32 | 14686 | 3254 | 1728809 |
| Transient ischaemic attack | 34.14 | 31.69 | 38 | 14680 | 4753 | 1727310 |
| Colon cancer | 33.76 | 31.69 | 25 | 14693 | 1839 | 1730224 |
| Concomitant disease progression | 33.58 | 31.69 | 16 | 14702 | 516 | 1731547 |
| Orthostatic intolerance | 33.56 | 31.69 | 11 | 14707 | 126 | 1731937 |
| Gastroenteritis | 33.43 | 31.69 | 26 | 14692 | 2058 | 1730005 |
| Melaena | 33.20 | 31.69 | 39 | 14679 | 5171 | 1726892 |
| Hip fracture | 33.13 | 31.69 | 24 | 14694 | 1706 | 1730357 |
| Foetal exposure during pregnancy | 33.11 | 31.69 | 43 | 14675 | 6316 | 1725747 |
| Dyspepsia | 32.91 | 31.69 | 38 | 14680 | 4947 | 1727116 |
| Electrocardiogram ST segment elevation | 32.84 | 31.69 | 19 | 14699 | 917 | 1731146 |
| Red blood cell sedimentation rate increased | 32.65 | 31.69 | 20 | 14698 | 1073 | 1730990 |
| Hepatic failure | 32.44 | 31.69 | 41 | 14677 | 5862 | 1726201 |
| Dependence on oxygen therapy | 32.30 | 31.69 | 7 | 14711 | 11 | 1732052 |
| Left ventricular failure | 32.24 | 31.69 | 17 | 14701 | 683 | 1731380 |
| Pulmonary congestion | 32.22 | 31.69 | 24 | 14694 | 1781 | 1730282 |
| Actinic keratosis | 32.19 | 31.69 | 16 | 14702 | 567 | 1731496 |
| Gastrointestinal haemorrhage | 32.19 | 31.69 | 66 | 14652 | 14201 | 1717862 |
| General physical condition abnormal | 31.96 | 31.69 | 17 | 14701 | 695 | 1731368 |
| Heart rate abnormal | 31.93 | 31.69 | 13 | 14705 | 285 | 1731778 |
| Atrioventricular block complete | 31.86 | 31.69 | 22 | 14696 | 1449 | 1730614 |
| Serum ferritin increased | 31.74 | 31.69 | 18 | 14700 | 836 | 1731227 |
| Neck pain | 31.71 | 31.69 | 31 | 14687 | 3335 | 1728728 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C09CA03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN Angiotensin II receptor blockers (ARBs), plain |
| ATC | C09DA03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and diuretics |
| ATC | C09DB01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
| ATC | C09DB08 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
| ATC | C09DX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
| ATC | C09DX02 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
| ATC | C09DX04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
| ATC | C09DX05 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
| ATC | C10BX10 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS HMG CoA reductase inhibitors, other combinations |
| FDA MoA | N0000000070 | Angiotensin 2 Receptor Antagonists |
| FDA EPC | N0000175561 | Angiotensin 2 Receptor Blocker |
| MeSH PA | D047228 | Angiotensin II Type 1 Receptor Blockers |
| MeSH PA | D057911 | Angiotensin Receptor Antagonists |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:61016 | angiotensin receptor antagonist |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Chronic heart failure | indication | 48447003 | |
| Left ventricular cardiac dysfunction | indication | 429589006 | |
| Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
| Diabetic renal disease | off-label use | 127013003 | |
| Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
| Nondiabetic Proteinuric Nephropathy | off-label use | ||
| Anuria | contraindication | 2472002 | DOID:2983 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Hyperkalemia | contraindication | 14140009 | |
| Secondary angle-closure glaucoma | contraindication | 21571006 | |
| Hypovolemia | contraindication | 28560003 | |
| Obstruction of bile duct | contraindication | 30144000 | |
| Dehydration | contraindication | 34095006 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Angioedema | contraindication | 41291007 | DOID:1558 |
| Hypokalemia | contraindication | 43339004 | |
| Low blood pressure | contraindication | 45007003 | |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Sympathectomy | contraindication | 57071006 | |
| Acute nephropathy | contraindication | 58574008 | |
| Hepatic failure | contraindication | 59927004 | |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
| Hypochloremic alkalosis | contraindication | 70134007 | |
| Hepatic coma | contraindication | 72836002 | DOID:12550 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Hypomagnesemia | contraindication | 190855004 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Impaired renal function disorder | contraindication | 197663003 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Neonatal hyperbilirubinemia | contraindication | 281610001 | |
| Pregnancy, function | contraindication | 289908002 | |
| Renal artery stenosis | contraindication | 302233006 | |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Azotemia | contraindication | 445009001 | |
| Severe Aortic Valve Stenosis | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.8 | acidic |
| pKa2 | 4.44 | acidic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 8796331 | Jan. 14, 2023 | TREATMENT OF HEART FAILURE |
| 26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 8796331 | Jan. 14, 2023 | TREATMENT OF HEART FAILURE |
| 51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 8796331 | Jan. 14, 2023 | TREATMENT OF HEART FAILURE |
| 103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9388134 | Nov. 8, 2026 | TREATMENT OF HEART FAILURE |
| 26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9388134 | Nov. 8, 2026 | TREATMENT OF HEART FAILURE |
| 51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | 9388134 | Nov. 8, 2026 | TREATMENT OF HEART FAILURE |
| 80MG | BYVALSON | ALLERGAN | N206302 | June 3, 2016 | DISCN | TABLET | ORAL | 7838552 | Oct. 4, 2027 | METHOD OF TREATING HYPERTENSION |
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | July 7, 2020 | NEW CHEMICAL ENTITY |
| 26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | July 7, 2020 | NEW CHEMICAL ENTITY |
| 51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | July 7, 2020 | NEW CHEMICAL ENTITY |
| 103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Jan. 7, 2021 | PEDIATRIC EXCLUSIVITY |
| 26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Jan. 7, 2021 | PEDIATRIC EXCLUSIVITY |
| 51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Jan. 7, 2021 | PEDIATRIC EXCLUSIVITY |
| 103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Oct. 1, 2022 | NEW PATIENT POPULATION |
| 26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Oct. 1, 2022 | NEW PATIENT POPULATION |
| 51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | Oct. 1, 2022 | NEW PATIENT POPULATION |
| 103MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | April 1, 2023 | PEDIATRIC EXCLUSIVITY |
| 26MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | April 1, 2023 | PEDIATRIC EXCLUSIVITY |
| 51MG | ENTRESTO | NOVARTIS PHARMS CORP | N207620 | July 7, 2015 | RX | TABLET | ORAL | April 1, 2023 | PEDIATRIC EXCLUSIVITY |
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor | GPCR | ANTAGONIST | Ki | 5.33 | CHEMBL | CHEMBL | |||
| Type-1B angiotensin II receptor | GPCR | IC50 | 8.72 | CHEMBL | |||||
| Type-1A angiotensin II receptor | GPCR | IC50 | 8.47 | CHEMBL | |||||
| Angiotensin II receptor (AT-1) type-1 | GPCR | IC50 | 8.57 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D000068756 | MESH_DESCRIPTOR_UI |
| C0719949 | UMLSCUI |
| D00400 | KEGG_DRUG |
| 108581009 | SNOMEDCT_US |
| 4020986 | VANDF |
| 006279 | NDDF |
| d04113 | MMSL |
| 5663 | MMSL |
| 69749 | RXNORM |
| 386876001 | SNOMEDCT_US |
| 53010 | MMSL |
| 80M03YXJ7I | UNII |
| 7016 | INN_ID |
| CHEMBL1069 | ChEMBL_ID |
| DB00177 | DRUGBANK_ID |
| CHEBI:9927 | CHEBI |
| 60846 | PUBCHEM_CID |
| 3937 | IUPHAR_LIGAND_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0314 | TABLET, FILM COATED | 80 mg | ORAL | NDA | 18 sections |
| Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0315 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 18 sections |
| Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0358 | TABLET | 80 mg | ORAL | NDA | 18 sections |
| Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0359 | TABLET | 160 mg | ORAL | NDA | 18 sections |
| Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0360 | TABLET | 320 mg | ORAL | NDA | 18 sections |
| Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0383 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 18 sections |
| Diovan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0423 | TABLET | 40 mg | ORAL | NDA | 18 sections |
| Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0471 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 18 sections |
| Diovan HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0472 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 18 sections |
| Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0488 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 18 sections |
| Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0489 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 18 sections |
| Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0490 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 18 sections |
| Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0491 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 18 sections |
| Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0559 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 18 sections |
| Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0560 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 18 sections |
| Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0561 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 18 sections |
| Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0562 | TABLET, FILM COATED | 160 mg | ORAL | NDA | 18 sections |
| Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0563 | TABLET, FILM COATED | 320 mg | ORAL | NDA | 18 sections |
| ENTRESTO | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0659 | TABLET, FILM COATED | 26 mg | ORAL | NDA | 19 sections |
| ENTRESTO | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0696 | TABLET, FILM COATED | 103 mg | ORAL | NDA | 19 sections |
| ENTRESTO | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0777 | TABLET, FILM COATED | 51 mg | ORAL | NDA | 19 sections |
| AMLODIPINE AND VALSARTAN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1721 | TABLET, FILM COATED | 160 mg | ORAL | ANDA | 18 sections |
| AMLODIPINE AND VALSARTAN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1722 | TABLET, FILM COATED | 160 mg | ORAL | ANDA | 18 sections |
| AMLODIPINE AND VALSARTAN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1723 | TABLET, FILM COATED | 320 mg | ORAL | ANDA | 18 sections |
| AMLODIPINE AND VALSARTAN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1724 | TABLET, FILM COATED | 320 mg | ORAL | ANDA | 18 sections |
| Valsartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-5807 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 18 sections |
| Valsartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-5813 | TABLET, FILM COATED | 80 mg | ORAL | ANDA | 18 sections |
| Valsartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-5814 | TABLET, FILM COATED | 160 mg | ORAL | ANDA | 18 sections |
| Valsartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-5815 | TABLET, FILM COATED | 320 mg | ORAL | ANDA | 18 sections |
| Valsartan and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-6321 | TABLET, FILM COATED | 80 mg | ORAL | ANDA | 18 sections |