valsartan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
angiotensin II receptor antagonists, antihypertensive (non-peptidic) 2806 137862-53-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • diovan
  • cardopan
  • valsartanin
  • valsartan
  • CGP 48933
  • CGP-48933
A tetrazole derivative and ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to treat HYPERTENSION. It has been approved in combination with sacubitril (under the name ENTRESTO) for the treatment of heart failure.
  • Molecular weight: 435.53
  • Formula: C24H29N5O3
  • CLOGP: 4.86
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 112.07
  • ALOGS: -4.28
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
80 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.18 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 13 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 10.50 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 23 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.49 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.04 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.50 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,MAPKAPK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,STK33,TEK 23
kinase-selectivity-class EIF2AK3,GRK2,MAP2K6 3
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.543 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
rat-kpuu-brain Rat brain Kpuu 0.005 % High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 22, 2000 PMDA Ciba-Geigy Japan
Dec. 23, 1996 FDA
Nov. 19, 2015 EMA Novartis Europharm Limited

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood pressure inadequately controlled 493.75 9.34 223 135976 6001 90486247
Blood pressure increased 478.13 9.34 970 135229 196247 90296001
Macular degeneration 465.95 9.34 415 135784 37555 90454693
Pemphigus 443.13 9.34 10 136189 326854 90165394
Hyponatraemia 409.20 9.34 726 135473 132812 90359436
Glossodynia 407.14 9.34 18 136181 321761 90170487
Hand deformity 390.70 9.34 12 136187 296350 90195898
Systemic lupus erythematosus 380.25 9.34 48 136151 361848 90130400
Acute kidney injury 352.95 9.34 1171 135028 319216 90173032
Cardiac failure congestive 334.27 9.34 561 135638 98133 90394115
Anti-cyclic citrullinated peptide antibody positive 313.68 9.34 9 136190 236424 90255824
Duodenal ulcer perforation 306.97 9.34 5 136194 221283 90270965
Pericarditis 293.21 9.34 32 136167 270119 90222129
Myocardial infarction 292.73 9.34 551 135648 105421 90386827
Wound 280.47 9.34 57 136142 302923 90189325
Folliculitis 273.97 9.34 7 136192 204346 90287902
Hyperkalaemia 267.75 9.34 404 135795 64560 90427688
Helicobacter infection 267.44 9.34 19 136180 226831 90265417
Oligohydramnios 265.83 9.34 154 136045 7047 90485201
Off label use 235.10 9.34 860 135339 1101392 89390856
Muscle injury 233.28 9.34 7 136192 176647 90315601
Maternal exposure during pregnancy 216.53 9.34 137 136062 359926 90132322
Thyroid disorder 207.52 9.34 189 136010 17596 90474652
Coronary artery disease 203.61 9.34 252 135947 33371 90458877
Alopecia 203.20 9.34 268 135931 494803 89997445
Arthropathy 199.56 9.34 155 136044 366087 90126161
Psoriatic arthropathy 199.10 9.34 49 136150 228286 90263962
Synovitis 194.79 9.34 128 136071 329624 90162624
Blood glucose increased 193.08 9.34 436 135763 94810 90397438
Hypotension 190.46 9.34 979 135220 324418 90167830
Oedema peripheral 181.24 9.34 818 135381 257097 90235151
Contraindicated product administered 180.15 9.34 131 136068 320008 90172240
Irritable bowel syndrome 177.99 9.34 46 136153 207402 90284846
Rheumatoid factor positive 172.50 9.34 26 136173 171624 90320624
Cerebral infarction 171.86 9.34 206 135993 26390 90465858
Renal failure 169.81 9.34 507 135692 130500 90361748
Discomfort 169.57 9.34 101 136098 274234 90218014
Treatment failure 166.32 9.34 128 136071 303800 90188448
Blister 166.07 9.34 88 136111 254910 90237338
Syncope 164.99 9.34 506 135693 132157 90360091
Blood creatinine increased 163.61 9.34 425 135774 100961 90391287
Therapeutic product effect decreased 159.53 9.34 111 136088 277460 90214788
Infusion related reaction 158.61 9.34 238 135961 416542 90075706
Joint swelling 156.68 9.34 326 135873 502974 89989274
Multi-organ disorder 156.23 9.34 73 136126 2127 90490121
Hypertensive crisis 154.91 9.34 161 136038 17623 90474625
Liver injury 153.83 9.34 34 136165 170533 90321715
Product use issue 153.01 9.34 162 136037 329757 90162491
Diabetes mellitus 152.09 9.34 315 135884 64560 90427688
Anaemia 151.73 9.34 978 135221 351824 90140424
Type 2 diabetes mellitus 151.31 9.34 58 136141 203186 90289062
Atrial fibrillation 150.04 9.34 492 135707 133119 90359129
Cardiac failure 148.81 9.34 431 135768 109065 90383183
Product use in unapproved indication 147.28 9.34 173 136026 336063 90156185
Swelling 144.75 9.34 255 135944 418803 90073445
Drug intolerance 139.20 9.34 290 135909 447301 90044947
Cerebrovascular accident 137.00 9.34 453 135746 123080 90369168
Hepatic enzyme increased 135.28 9.34 208 135991 360528 90131720
Impaired healing 132.79 9.34 95 136104 234104 90258144
Lip dry 129.73 9.34 5 136194 100950 90391298
Joint range of motion decreased 128.62 9.34 24 136175 135619 90356629
Ill-defined disorder 126.07 9.34 60 136139 184831 90307417
Facet joint syndrome 126.00 9.34 5 136194 98384 90393864
Gastrointestinal disorder 120.15 9.34 125 136074 256562 90235686
Dizziness 119.99 9.34 1383 134816 587901 89904347
Fibromyalgia 119.13 9.34 82 136117 206187 90286061
Intentional product use issue 119.05 9.34 91 136108 216801 90275447
Glaucoma 115.25 9.34 149 136050 20606 90471642
Fall 111.94 9.34 1161 135038 480649 90011599
Grip strength decreased 108.34 9.34 8 136191 92568 90399680
Stomatitis 108.21 9.34 153 136046 274545 90217703
Blood pressure decreased 107.77 9.34 301 135898 74594 90417654
Musculoskeletal stiffness 107.33 9.34 175 136024 296357 90195891
Infection 107.22 9.34 241 135958 361853 90130395
Diabetes mellitus inadequate control 106.68 9.34 136 136063 18548 90473700
Breast cancer stage III 105.79 9.34 5 136194 84442 90407806
Eye haemorrhage 104.95 9.34 101 136098 10079 90482169
Lower respiratory tract infection 103.38 9.34 135 136064 250524 90241724
Prescribed overdose 102.27 9.34 13 136186 97612 90394636
Rash 100.21 9.34 743 135456 795357 89696891
Live birth 98.09 9.34 5 136194 79102 90413146
Renal impairment 97.38 9.34 364 135835 105057 90387191
Colitis microscopic 97.14 9.34 101 136098 11058 90481190
Bradycardia 94.30 9.34 309 135890 83538 90408710
Deep vein thrombosis postoperative 92.75 9.34 3 136196 70806 90421442
Bursitis 92.41 9.34 41 136158 131613 90360635
Chronic sinusitis 92.36 9.34 144 136055 23658 90468590
Migraine 92.17 9.34 90 136109 190302 90301946
C-reactive protein abnormal 92.13 9.34 38 136161 127391 90364857
Bronchial haemorrhage 91.08 9.34 35 136164 618 90491630
Myalgia 90.14 9.34 509 135690 174616 90317632
Dehydration 89.03 9.34 548 135651 193899 90298349
Blood urea increased 88.75 9.34 162 136037 30251 90461997
Condition aggravated 88.33 9.34 529 135670 595016 89897232
Exposure during pregnancy 87.85 9.34 139 136060 238271 90253977
Pulmonary oedema 87.84 9.34 248 135951 61832 90430416
Diverticulum intestinal 87.33 9.34 87 136112 9055 90483193
Blood pressure systolic increased 85.43 9.34 236 135963 58109 90434139
Paraesthesia oral 85.34 9.34 163 136036 31496 90460752
Bronchial neoplasm 83.31 9.34 31 136168 499 90491749
Drug interaction 83.05 9.34 704 135495 275749 90216499
Injury 82.69 9.34 105 136094 197244 90295004
Mobility decreased 82.54 9.34 157 136042 250577 90241671
Sleep disorder 80.27 9.34 108 136091 197922 90294326
Mitral valve incompetence 80.16 9.34 131 136068 22393 90469855
Abdominal discomfort 80.03 9.34 407 135792 476921 90015327
Physical deconditioning 77.75 9.34 46 136153 2189 90490059
Haematochezia 77.65 9.34 259 135940 70654 90421594
Chronic kidney disease 76.46 9.34 206 135993 49985 90442263
Procedural pain 75.85 9.34 160 136039 33200 90459048
Sinusitis 75.79 9.34 263 135936 342825 90149423
Diverticulitis 75.52 9.34 192 136007 44995 90447253
Liver function test increased 74.32 9.34 18 136181 84837 90407411
Cardiovascular disorder 73.57 9.34 96 136103 13396 90478852
Angina pectoris 73.52 9.34 174 136025 38986 90453262
Rheumatoid arthritis 72.25 9.34 290 135909 362324 90129924
Tachyarrhythmia 72.14 9.34 62 136137 5344 90486904
Arrhythmia 70.88 9.34 180 136019 42152 90450096
Rhabdomyolysis 70.80 9.34 203 135996 51053 90441195
Vaginal flatulence 70.59 9.34 91 136108 12547 90479701
Gastrointestinal haemorrhage 69.96 9.34 295 135904 89953 90402295
Nasal turbinate hypertrophy 69.89 9.34 32 136167 889 90491359
Lymphatic fistula 69.71 9.34 37 136162 1424 90490824
Night sweats 69.39 9.34 55 136144 128711 90363537
Wound infection 68.80 9.34 37 136162 106365 90385883
Femoral hernia incarcerated 68.60 9.34 37 136162 1471 90490777
Completed suicide 68.56 9.34 70 136129 144988 90347260
Dislocation of vertebra 67.95 9.34 4 136195 55964 90436284
Product prescribing error 66.71 9.34 143 136056 30002 90462246
Adjustment disorder with depressed mood 66.13 9.34 5 136194 56748 90435500
Bronchial disorder 64.90 9.34 36 136163 1514 90490734
Malnutrition 64.78 9.34 107 136092 18451 90473797
Acute myocardial infarction 64.39 9.34 154 136045 34736 90457512
Blepharospasm 64.28 9.34 5 136194 55440 90436808
Peripheral venous disease 64.02 9.34 23 136176 83898 90408350
Nail disorder 64.01 9.34 7 136192 59060 90433188
Endometrial ablation 63.49 9.34 31 136168 998 90491250
Drug hypersensitivity 63.42 9.34 422 135777 463187 90029061
Asthmatic crisis 63.03 9.34 38 136161 1872 90490376
Pancreatic steatosis 62.96 9.34 36 136163 1606 90490642
Arterial haemorrhage 62.80 9.34 42 136157 2481 90489767
Hiatus hernia 62.80 9.34 126 136073 25235 90467013
Hypoglycaemia 62.68 9.34 239 135960 69609 90422639
Hepatic cyst 61.81 9.34 62 136137 6506 90485742
Prescribed underdose 61.75 9.34 18 136181 75001 90417247
Nasopharyngitis 61.66 9.34 359 135840 406745 90085503
Proctitis 61.56 9.34 94 136105 15165 90477083
Blood creatine phosphokinase increased 61.53 9.34 149 136050 33874 90458374
Pain 61.23 9.34 1092 135107 995249 89496999
Haematoma 61.23 9.34 162 136037 38886 90453362
Wound infection pseudomonas 61.02 9.34 38 136161 1985 90490263
Radiculopathy 61.01 9.34 104 136095 18401 90473847
Female genital tract fistula 59.67 9.34 101 136098 17767 90474481
Rhonchi 58.77 9.34 43 136156 2935 90489313
Pregnancy 58.76 9.34 11 136188 62036 90430212
Cardiomegaly 58.01 9.34 103 136096 18822 90473426
Hip arthroplasty 57.94 9.34 21 136178 76187 90416061
Tricuspid valve incompetence 57.78 9.34 96 136103 16635 90475613
Hypersensitivity 57.70 9.34 423 135776 454254 90037994
Autoimmune disorder 56.92 9.34 22 136177 76722 90415526
Blood pressure diastolic decreased 56.79 9.34 125 136074 26701 90465547
Therapy non-responder 55.95 9.34 74 136125 136630 90355618
Breast cancer 55.90 9.34 193 136006 53568 90438680
Pulmonary hypoplasia 55.43 9.34 21 136178 356 90491892
Cough 55.19 9.34 819 135380 368143 90124105
Urticaria 55.04 9.34 262 135937 312472 90179776
Blood cholesterol increased 54.79 9.34 147 136052 207865 90284383
Hypokalaemia 54.11 9.34 360 135839 130756 90361492
Hyperuricaemia 53.50 9.34 58 136141 6661 90485587
Adverse drug reaction 53.25 9.34 58 136141 116643 90375605
Transient ischaemic attack 52.06 9.34 163 136036 43013 90449235
Seroma 51.13 9.34 40 136159 3020 90489228
Onychomadesis 51.01 9.34 5 136194 45993 90446255
Road traffic accident 50.78 9.34 52 136147 107574 90384674
Pulmonary fibrosis 49.53 9.34 53 136146 107450 90384798
Aortic valve stenosis 49.34 9.34 45 136154 4195 90488053
Labile hypertension 49.09 9.34 21 136178 494 90491754
Angina unstable 48.91 9.34 57 136142 7086 90485162
Taste disorder 48.44 9.34 16 136183 61530 90430718
Loss of consciousness 47.97 9.34 368 135831 139870 90352378
Drug ineffective for unapproved indication 47.96 9.34 20 136179 66624 90425624
Lichen planopilaris 47.90 9.34 16 136183 184 90492064
Forced expiratory volume decreased 47.76 9.34 51 136148 5757 90486491
Adverse event 47.60 9.34 64 136135 117354 90374894
Vaginal discharge 47.36 9.34 96 136103 19368 90472880
Nervousness 47.15 9.34 135 136064 33921 90458327
Ventricular extrasystoles 47.06 9.34 77 136122 13173 90479075
Blood sodium decreased 46.84 9.34 118 136081 27495 90464753
Exercise tolerance decreased 46.36 9.34 57 136142 7494 90484754
Aortic arteriosclerosis 45.56 9.34 57 136142 7627 90484621
Ear infection 45.49 9.34 24 136175 69751 90422497
Obstructive airways disorder 45.40 9.34 112 136087 25757 90466491
Blood lactate dehydrogenase increased 45.23 9.34 112 136087 25820 90466428
Altered state of consciousness 44.63 9.34 126 136073 31406 90460842
Pericardial effusion 44.36 9.34 139 136060 36694 90455554
Hypochromic anaemia 44.33 9.34 32 136167 2139 90490109
Cardiac failure chronic 43.67 9.34 48 136151 5598 90486650
Injection site scab 43.62 9.34 21 136178 655 90491593
Faecaloma 43.13 9.34 65 136134 10366 90481882
Injection site reaction 42.86 9.34 45 136154 92035 90400213
Back injury 42.61 9.34 9 136190 46613 90445635
Arthralgia 42.58 9.34 870 135329 777652 89714596
Antinuclear antibody negative 42.30 9.34 16 136183 270 90491978
Obesity 42.27 9.34 58 136141 105449 90386799
Asthenia 42.17 9.34 1075 135124 532676 89959572
Renal artery stenosis 41.98 9.34 31 136168 2146 90490102
Blood pressure fluctuation 41.92 9.34 173 136026 52240 90440008
Haemarthrosis 41.88 9.34 40 136159 3954 90488294
Feeling abnormal 41.59 9.34 409 135790 166826 90325422
Breast cancer stage II 41.49 9.34 3 136196 35331 90456917
Bone erosion 41.35 9.34 14 136185 53007 90439241
Lower limb fracture 41.34 9.34 40 136159 84973 90407275
Myocardial ischaemia 40.83 9.34 74 136125 13740 90478508
Skin reaction 39.90 9.34 87 136112 18466 90473782
Blood potassium increased 39.82 9.34 93 136106 20656 90471592
Melaena 39.79 9.34 129 136070 34668 90457580
Chest pain 38.96 9.34 686 135513 318959 90173289
Blood pressure abnormal 38.74 9.34 89 136110 19556 90472692
Gamma-glutamyltransferase increased 38.37 9.34 135 136064 37817 90454431
Weight decreased 38.32 9.34 792 135407 379118 90113130
Haematuria 37.70 9.34 127 136072 34810 90457438
Angioedema 37.70 9.34 195 136004 64681 90427567
Product contamination 37.64 9.34 23 136176 1161 90491087
Wheezing 37.60 9.34 207 135992 237873 90254375
Lung disorder 37.18 9.34 109 136090 149774 90342474
Coombs positive haemolytic anaemia 37.10 9.34 17 136182 473 90491775
Eructation 36.99 9.34 62 136137 10820 90481428
Weight increased 36.84 9.34 426 135773 417501 90074747
Venous pressure jugular increased 36.79 9.34 18 136181 582 90491666
Blood uric acid increased 36.20 9.34 51 136148 7653 90484595
COVID-19 36.19 9.34 131 136068 168712 90323536
Anuria 35.95 9.34 73 136126 14745 90477503
Gastritis haemorrhagic 35.54 9.34 26 136173 1774 90490474
X-ray abnormal 35.41 9.34 12 136187 45412 90446836
Fear of disease 35.37 9.34 24 136175 1452 90490796
Fatigue 34.50 9.34 1402 134797 1152621 89339627
Dyspnoea exertional 34.48 9.34 206 135993 72082 90420166
Complex regional pain syndrome 34.48 9.34 30 136169 2629 90489619
Coronary artery stenosis 34.36 9.34 41 136158 5225 90487023
Vascular resistance pulmonary decreased 34.33 9.34 10 136189 70 90492178
Groin pain 34.30 9.34 64 136135 12149 90480099
Lymphocyte stimulation test positive 33.96 9.34 16 136183 475 90491773
Bundle branch block left 33.84 9.34 50 136149 7835 90484413
Postoperative wound infection 33.60 9.34 67 136132 13359 90478889
Adverse reaction 33.56 9.34 3 136196 29709 90462539
Confusional state 33.52 9.34 395 135804 385810 90106438
Atrioventricular block complete 33.48 9.34 56 136143 9755 90482493
Abortion spontaneous 33.22 9.34 20 136179 54036 90438212
Renal cyst 32.86 9.34 65 136134 12885 90479363
Spinal osteoarthritis 32.66 9.34 82 136117 19066 90473182
Gastric ulcer haemorrhage 32.46 9.34 40 136159 5271 90486977
Hypercholesterolaemia 32.45 9.34 64 136135 100828 90391420
Thrombotic stroke 32.24 9.34 16 136183 534 90491714
Musculoskeletal pain 32.17 9.34 140 136059 171111 90321137
Progressive bulbar palsy 32.09 9.34 9 136190 54 90492194
Peripheral swelling 31.94 9.34 433 135766 412673 90079575
Palpitations 31.40 9.34 329 135870 136399 90355849
Fear 31.35 9.34 74 136125 16548 90475700
Epilepsy 31.14 9.34 47 136152 82159 90410089
Interstitial lung disease 31.03 9.34 209 135990 76196 90416052
Hyperlipidaemia 30.91 9.34 90 136109 22826 90469422
Multiple drug therapy 30.88 9.34 45 136154 6964 90485284
Left ventricular hypertrophy 30.86 9.34 42 136157 6102 90486146
Coronary arterial stent insertion 30.84 9.34 29 136170 2811 90489437
Incorrect route of product administration 30.73 9.34 19 136180 50607 90441641
Sinus node dysfunction 30.27 9.34 39 136160 5373 90486875
Forced vital capacity decreased 30.26 9.34 20 136179 1158 90491090
Lacunar infarction 30.18 9.34 31 136168 3346 90488902
Joint stiffness 30.17 9.34 44 136155 77998 90414250
Brain stem stroke 30.09 9.34 14 136185 404 90491844
Iron deficiency anaemia 30.08 9.34 91 136108 23571 90468677
Product impurity 29.91 9.34 8 136191 39 90492209
Pulmonary hypertension 29.89 9.34 135 136064 42388 90449860
Hypoaesthesia 29.77 9.34 315 135884 313895 90178353
Hospitalisation 29.75 9.34 96 136103 128004 90364244
Haemoglobin decreased 29.69 9.34 373 135826 161583 90330665
Wound dehiscence 29.55 9.34 40 136159 5782 90486466
Colon cancer 29.07 9.34 56 136143 10888 90481360
Cardiac disorder 29.03 9.34 165 136034 56707 90435541
Loss of personal independence in daily activities 28.90 9.34 106 136093 135999 90356249
Hyperglycaemia 28.79 9.34 152 136047 50818 90441430
Rectal haemorrhage 28.77 9.34 218 135981 82526 90409722
Lupus-like syndrome 28.74 9.34 19 136180 48827 90443421
Concomitant disease progression 28.57 9.34 25 136174 2207 90490041
Urinary tract infection 28.49 9.34 630 135569 305002 90187246
Cerebral haemorrhage 28.43 9.34 115 136084 34407 90457841
Dysuria 28.38 9.34 126 136073 39275 90452973
Sleep disorder due to a general medical condition 28.27 9.34 16 136183 44722 90447526
Gastritis 28.19 9.34 131 136068 41622 90450626
Dementia Alzheimer's type 28.18 9.34 18 136181 983 90491265
Arteriosclerosis 28.17 9.34 55 136144 10798 90481450
Coronary artery occlusion 28.10 9.34 48 136151 8506 90483742
Inflammatory marker increased 28.05 9.34 50 136149 9164 90483084
Red blood cell sedimentation rate increased 27.78 9.34 51 136148 82544 90409704
Myelosuppression 27.49 9.34 24 136175 53567 90438681
Dry mouth 27.45 9.34 163 136036 183896 90308352
Product odour abnormal 27.26 9.34 21 136178 1550 90490698
Sciatica 27.17 9.34 71 136128 101311 90390937
Bronchitis 27.09 9.34 350 135849 152577 90339671
Toxicity to various agents 27.09 9.34 289 135910 287557 90204691
Dyschezia 26.88 9.34 27 136172 2838 90489410
Metabolic acidosis 26.77 9.34 159 136040 55517 90436731
Coeliac disease 26.73 9.34 17 136182 44593 90447655
Cardiac pacemaker insertion 26.62 9.34 33 136166 4374 90487874
Walking aid user 26.62 9.34 10 136189 35496 90456752
Knee arthroplasty 26.55 9.34 53 136146 83129 90409119
Recalled product administered 26.34 9.34 16 136183 799 90491449
Major depression 26.22 9.34 51 136148 9984 90482264
Multiple injuries 26.13 9.34 22 136177 1843 90490405
Dyspnoea 26.12 9.34 1594 134605 879361 89612887
Visual acuity reduced 26.06 9.34 86 136113 23324 90468924
Chronic obstructive pulmonary disease 25.94 9.34 195 136004 73634 90418614
Febrile neutropenia 25.92 9.34 136 136063 158213 90334035
Monocyte count abnormal 25.71 9.34 11 136188 259 90491989
Heart rate increased 25.61 9.34 271 135928 112631 90379617
Cardiogenic shock 25.57 9.34 88 136111 24380 90467868
Frustration tolerance decreased 25.53 9.34 44 136155 7852 90484396
Malaise 25.25 9.34 1099 135100 584887 89907361
Oral candidiasis 25.25 9.34 113 136086 35342 90456906
Platelet aggregation abnormal 25.24 9.34 6 136193 16 90492232
Left ventricular dysfunction 25.20 9.34 63 136136 14606 90477642
Disability 25.14 9.34 15 136184 40730 90451518
Hypochloraemia 25.13 9.34 25 136174 2597 90489651
Basal ganglion degeneration 25.05 9.34 12 136187 370 90491878
Hypertensive heart disease 24.99 9.34 25 136174 2615 90489633
Pollakiuria 24.88 9.34 107 136092 32898 90459350
Lactic acidosis 24.84 9.34 145 136054 50318 90441930
Granuloma 24.81 9.34 38 136161 6147 90486101
Ventricular hypertrophy 24.80 9.34 28 136171 3363 90488885
Emotional distress 24.73 9.34 115 136084 36547 90455701
Colitis 24.72 9.34 185 136014 69757 90422491
Exostosis 24.69 9.34 26 136173 53108 90439140
Circulatory collapse 24.67 9.34 88 136111 24816 90467432
Product substitution issue 24.55 9.34 71 136128 17937 90474311
Hypertensive cardiomyopathy 24.45 9.34 11 136188 293 90491955
Motor neurone disease 24.38 9.34 10 136189 211 90492037
Drug abuse 24.17 9.34 55 136144 82292 90409956
Therapy interrupted 23.87 9.34 24 136175 50084 90442164
Gastroenteritis 23.78 9.34 97 136102 29132 90463116
Acral lentiginous melanoma 23.58 9.34 5 136194 6 90492242
Renal cell carcinoma 23.53 9.34 29 136170 3822 90488426
Pneumothorax traumatic 23.47 9.34 9 136190 158 90492090
International normalised ratio increased 23.31 9.34 136 136063 47180 90445068
Speech disorder 23.10 9.34 132 136067 45453 90446795
Renin decreased 23.06 9.34 8 136191 104 90492144
Kyphosis 22.97 9.34 25 136174 2883 90489365
Hypertensive emergency 22.86 9.34 22 136177 2195 90490053
Gingival ulceration 22.73 9.34 16 136183 1028 90491220
Nephrogenic anaemia 22.70 9.34 23 136176 2443 90489805
Ischaemic stroke 22.54 9.34 79 136120 22087 90470161
Dementia 22.53 9.34 83 136116 23778 90468470
Rectal prolapse 22.44 9.34 22 136177 2245 90490003
Intentional product misuse 22.33 9.34 65 136134 89539 90402709
Haematemesis 22.17 9.34 105 136094 33621 90458627
Osteogenesis imperfecta 22.15 9.34 15 136184 905 90491343
Hepatic function abnormal 22.13 9.34 132 136067 46156 90446092
Serotonin syndrome 22.09 9.34 114 136085 37773 90454475
Left-to-right cardiac shunt 22.04 9.34 10 136189 272 90491976
Product contamination chemical 22.03 9.34 5 136194 10 90492238
BRASH syndrome 21.98 9.34 20 136179 1859 90490389
Glycosylated haemoglobin increased 21.84 9.34 62 136137 15500 90476748
Coronary artery bypass 21.79 9.34 22 136177 2327 90489921
Peak expiratory flow rate decreased 21.78 9.34 13 136186 629 90491619
Tremor 21.69 9.34 337 135862 152836 90339412
Disease progression 21.64 9.34 142 136057 156473 90335775
Gout 21.58 9.34 65 136134 16794 90475454
Metastatic bronchial carcinoma 21.55 9.34 9 136190 199 90492049
Monoplegia 21.38 9.34 27 136172 3647 90488601
Diabetic nephropathy 21.35 9.34 19 136180 1715 90490533
Wrong technique in product usage process 21.31 9.34 182 136017 71389 90420859
Intestinal polyp 21.15 9.34 18 136181 1531 90490717
Proteinuria 21.14 9.34 80 136119 23211 90469037
Lung diffusion test decreased 21.09 9.34 14 136185 817 90491431
Ankle fracture 21.06 9.34 73 136126 20297 90471951
Aspartate aminotransferase increased 21.01 9.34 242 135957 102695 90389553
Gastrointestinal stromal tumour 20.92 9.34 17 136182 1356 90490892
Atrioventricular block 20.88 9.34 43 136156 8772 90483476
Cranial sutures widening 20.86 9.34 5 136194 14 90492234
Retrograde amnesia 20.85 9.34 12 136187 542 90491706
Angiotensin converting enzyme inhibitor foetopathy 20.85 9.34 6 136193 40 90492208
Breast neoplasm 20.84 9.34 18 136181 1562 90490686
Anxiety disorder 20.82 9.34 31 136168 4891 90487357
Herpes simplex reactivation 20.76 9.34 15 136184 1004 90491244
Antiphospholipid syndrome 20.55 9.34 21 136178 2253 90489995
Hyponatraemic syndrome 20.46 9.34 12 136187 562 90491686
Inappropriate antidiuretic hormone secretion 20.25 9.34 70 136129 19435 90472813
Cardiac failure acute 20.25 9.34 51 136148 11878 90480370
Neutrophil function disorder 20.13 9.34 5 136194 17 90492231
Inguinal hernia 20.10 9.34 20 136179 2078 90490170
Anaesthesia 20.04 9.34 11 136188 453 90491795
Withdrawal hypertension 19.85 9.34 8 136191 161 90492087
Diverticulum 19.75 9.34 51 136148 12062 90480186
Neonatal seizure 19.65 9.34 12 136187 605 90491643
Glomerular filtration rate decreased 19.57 9.34 63 136136 16869 90475379
Sleep apnoea syndrome 19.55 9.34 97 136102 31650 90460598
Product dose omission issue 19.32 9.34 315 135884 291372 90200876
Renal neoplasm 19.24 9.34 17 136182 1520 90490728
Body height decreased 19.16 9.34 50 136149 11899 90480349
Infarction 18.91 9.34 23 136176 2990 90489258
Potentiating drug interaction 18.90 9.34 32 136167 5630 90486618
Azotaemia 18.89 9.34 31 136168 5317 90486931
Onychomycosis 18.86 9.34 17 136182 37359 90454889
Periodontitis 18.84 9.34 26 136173 3827 90488421
Brain contusion 18.83 9.34 12 136187 653 90491595
Brain natriuretic peptide increased 18.81 9.34 33 136166 5972 90486276
Blood aldosterone decreased 18.77 9.34 4 136195 5 90492243
Therapy partial responder 18.68 9.34 5 136194 22038 90470210
Nodal rhythm 18.67 9.34 18 136181 1800 90490448
Nocturia 18.63 9.34 45 136154 10210 90482038
Blood alkaline phosphatase increased 18.62 9.34 130 136069 47949 90444299
Basilar artery occlusion 18.55 9.34 8 136191 192 90492056
Contusion 18.44 9.34 266 135933 250950 90241298
Faeces discoloured 18.34 9.34 72 136127 21248 90471000
Laryngitis 18.29 9.34 30 136169 50723 90441525
Arrhythmogenic right ventricular dysplasia 18.27 9.34 5 136194 27 90492221
Vertebral artery occlusion 18.25 9.34 8 136191 200 90492048
Epistaxis 18.22 9.34 202 135997 84923 90407325
Tissue infiltration 18.17 9.34 13 136186 857 90491391
Peritonitis 18.15 9.34 68 136131 19637 90472611
Carotid artery disease 18.15 9.34 17 136182 1640 90490608
Ischaemic cardiomyopathy 18.14 9.34 21 136178 2592 90489656
Neutropenia 17.99 9.34 234 135965 224670 90267578
Productive cough 17.95 9.34 186 136013 76877 90415371
Blood sodium increased 17.91 9.34 23 136176 3159 90489089
Pulmonary thrombosis 17.86 9.34 43 136156 9739 90482509
Drug ineffective 17.82 9.34 1816 134383 1382482 89109766
Finger deformity 17.78 9.34 14 136185 32883 90459365
Bladder transitional cell carcinoma 17.72 9.34 13 136186 891 90491357
Gait inability 17.70 9.34 138 136061 146318 90345930
Post-anoxic myoclonus 17.69 9.34 5 136194 31 90492217
Haemodialysis 17.66 9.34 40 136159 8707 90483541
Carotid artery stenosis 17.61 9.34 30 136169 5304 90486944
Diabetic retinopathy 17.57 9.34 21 136178 2681 90489567
Renal disorder 17.49 9.34 107 136092 37752 90454496
Skin texture abnormal 17.43 9.34 11 136188 588 90491660
Affective disorder 17.28 9.34 37 136162 7756 90484492
Gastritis erosive 17.25 9.34 34 136165 6721 90485527
Polyuria 17.12 9.34 43 136156 9997 90482251
Impaired work ability 17.12 9.34 4 136195 19322 90472926
Lipoedema 17.11 9.34 9 136190 340 90491908
Ophthalmic vein thrombosis 17.06 9.34 9 136190 342 90491906
Uterine enlargement 17.06 9.34 15 136184 1333 90490915
Vertigo 16.98 9.34 170 136029 69641 90422607
Orthopnoea 16.97 9.34 34 136165 6801 90485447
Duodenal polyp 16.94 9.34 8 136191 239 90492009
Stress 16.90 9.34 192 136007 81203 90411045
Urticaria chronic 16.80 9.34 12 136187 789 90491459
Coronary angioplasty 16.76 9.34 6 136193 86 90492162
Respiration abnormal 16.73 9.34 37 136162 7926 90484322
Stenosis 16.61 9.34 18 136181 2066 90490182
Foot deformity 16.58 9.34 41 136158 59610 90432638
Renal atrophy 16.58 9.34 17 136182 1831 90490417
Diapedesis 16.51 9.34 3 136196 0 90492248
Congenital renal disorder 16.51 9.34 3 136196 0 90492248
Transitional cell cancer of the renal pelvis and ureter 16.48 9.34 4 136195 12 90492236
No adverse event 16.45 9.34 50 136149 67932 90424316
Drug resistance 16.40 9.34 13 136186 30436 90461812
Erythema 16.40 9.34 456 135743 228790 90263458
Femur fracture 16.35 9.34 122 136077 45960 90446288
Functional residual capacity increased 16.33 9.34 6 136193 93 90492155
Cataract 16.32 9.34 173 136026 71919 90420329
Nephrogenic systemic fibrosis 16.14 9.34 25 136174 4083 90488165
Sinus bradycardia 16.03 9.34 59 136140 16893 90475355
Intervertebral disc protrusion 15.97 9.34 82 136117 27114 90465134
Pyometra 15.88 9.34 6 136193 101 90492147
Periodontal disease 15.82 9.34 16 136183 1696 90490552
Gastric cancer 15.80 9.34 28 136171 5108 90487140
Large intestine polyp 15.80 9.34 40 136159 9346 90482902
Product taste abnormal 15.80 9.34 19 136180 2441 90489807
Tessellated fundus 15.78 9.34 5 136194 48 90492200
Erysipelas 15.68 9.34 39 136160 9013 90483235
Face oedema 15.62 9.34 73 136126 23245 90469003
Oesophageal food impaction 15.61 9.34 8 136191 286 90491962
Parkinson's disease 15.57 9.34 13 136186 1077 90491171
Deep vein thrombosis 15.52 9.34 208 135991 91412 90400836
Affect lability 15.49 9.34 4 136195 18059 90474189
Ligament injury 15.47 9.34 13 136186 1086 90491162
Sinus tachycardia 15.40 9.34 84 136115 28429 90463819
Heart rate decreased 15.37 9.34 135 136064 53370 90438878
Low density lipoprotein increased 15.25 9.34 36 136163 8049 90484199
Atrial flutter 15.23 9.34 43 136156 10715 90481533
Pruritus 15.22 9.34 662 135537 540863 89951385
Blood chloride decreased 15.17 9.34 31 136168 6288 90485960
Cerebral arteriosclerosis 15.14 9.34 8 136191 305 90491943
Occult blood positive 15.14 9.34 24 136175 3999 90488249
Renin increased 15.11 9.34 7 136192 200 90492048
Device dislocation 15.09 9.34 15 136184 31467 90460781
Blood aldosterone increased 15.04 9.34 7 136192 202 90492046
Acute phosphate nephropathy 15.04 9.34 4 136195 19 90492229
Chronic gastritis 15.03 9.34 23 136176 3718 90488530
Ear pain 15.01 9.34 41 136158 57661 90434587
Anaphylactic reaction 14.98 9.34 74 136125 87450 90404798
Gastric mucosa erythema 14.90 9.34 9 136190 445 90491803
Depressed level of consciousness 14.80 9.34 171 136028 72613 90419635
Peripheral vascular disorder 14.80 9.34 31 136168 6400 90485848
Ventricular septal defect 14.77 9.34 28 136171 5379 90486869
Hypothyroidism 14.72 9.34 133 136066 52994 90439254
Merycism 14.72 9.34 8 136191 323 90491925
Movement disorder 14.68 9.34 84 136115 28935 90463313
Carpal tunnel syndrome 14.65 9.34 73 136126 23855 90468393
Vascular calcification 14.65 9.34 11 136188 781 90491467
Coronary artery restenosis 14.63 9.34 8 136191 327 90491921
Therapeutic drug monitoring analysis incorrectly performed 14.50 9.34 8 136191 333 90491915
Sinus arrest 14.48 9.34 17 136182 2129 90490119
Fabry's disease 14.43 9.34 3 136196 3 90492245
Product administration error 14.37 9.34 78 136121 26345 90465903
Underdose 14.34 9.34 38 136161 53979 90438269
Duodenal ulcer 14.34 9.34 39 136160 9513 90482735
Ulcer 14.28 9.34 17 136182 32865 90459383
Inflammation 14.21 9.34 186 136013 178406 90313842
Injection site pain 14.16 9.34 180 136019 173519 90318729
Oesophageal achalasia 13.99 9.34 10 136189 658 90491590
Heliotrope rash 13.98 9.34 7 136192 238 90492010
Osteopenia 13.96 9.34 70 136129 22932 90469316
Catheterisation cardiac 13.95 9.34 26 136173 4930 90487318
Joint contracture 13.95 9.34 15 136184 1707 90490541
Normal newborn 13.86 9.34 9 136190 23353 90468895
Prothrombin time prolonged 13.78 9.34 39 136160 9733 90482515
Thyroxine decreased 13.77 9.34 10 136189 675 90491573
Upper-airway cough syndrome 13.75 9.34 52 136147 15083 90477165
Femoral neck fracture 13.62 9.34 40 136159 10193 90482055
Hepatic cirrhosis 13.60 9.34 49 136150 63204 90429044
Food allergy 13.57 9.34 11 136188 25467 90466781
Lymphocyte count abnormal 13.57 9.34 11 136188 874 90491374
Bradycardia neonatal 13.51 9.34 12 136187 1081 90491167
Blood glucose abnormal 13.50 9.34 38 136161 9454 90482794
Gastrointestinal cancer metastatic 13.46 9.34 5 136194 80 90492168
Subarachnoid haemorrhage 13.46 9.34 58 136141 17846 90474402
Haemorrhagic stroke 13.44 9.34 30 136169 6466 90485782
Normochromic normocytic anaemia 13.42 9.34 26 136173 5076 90487172
Peptic ulcer 13.31 9.34 27 136172 5448 90486800
Deafness 13.30 9.34 68 136131 22446 90469802
Ulcer haemorrhage 13.25 9.34 12 136187 26309 90465939
Airway remodelling 13.24 9.34 5 136194 84 90492164
Upper respiratory tract infection 13.23 9.34 126 136073 128192 90364056
Abdominal wound dehiscence 13.22 9.34 7 136192 268 90491980
Lymphostasis 13.22 9.34 3 136196 6 90492242
Blood pressure ambulatory abnormal 13.22 9.34 3 136196 6 90492242
Urine albumin/creatinine ratio increased 13.20 9.34 9 136190 549 90491699
Device issue 13.12 9.34 15 136184 29522 90462726
Splenomegaly 13.09 9.34 46 136153 12878 90479370
Oedema mouth 13.04 9.34 17 136182 2369 90489879
Prerenal failure 13.04 9.34 16 136183 2099 90490149
Cell marker increased 13.03 9.34 7 136192 276 90491972
Intervertebral disc degeneration 13.02 9.34 56 136143 17218 90475030
Cutaneous lymphoma 12.90 9.34 6 136193 173 90492075
Hypertensive encephalopathy 12.90 9.34 10 136189 745 90491503
Colitis ulcerative 12.89 9.34 143 136056 60123 90432125
Psoriasis 12.84 9.34 151 136048 147603 90344645
Cholelithiasis 12.84 9.34 128 136071 52378 90439870
Product complaint 12.78 9.34 47 136152 13453 90478795
Bone pain 12.77 9.34 146 136053 61837 90430411
Scar pain 12.76 9.34 7 136192 288 90491960
Ischaemia 12.74 9.34 26 136173 5269 90486979
Pemphigoid 12.71 9.34 36 136163 8990 90483258
Alanine aminotransferase increased 12.66 9.34 249 135950 118089 90374159
Hemiplegia 12.65 9.34 53 136146 16107 90476141
Rhinitis 12.63 9.34 47 136152 13525 90478723
Ovarian cancer 12.63 9.34 30 136169 6737 90485511
Immunodeficiency 12.58 9.34 29 136170 43205 90449043
Anti-neutrophil cytoplasmic antibody positive vasculitis 12.58 9.34 22 136177 3971 90488277
Subdural haematoma 12.57 9.34 54 136145 16591 90475657
Toxic skin eruption 12.56 9.34 52 136147 15722 90476526
Cardiac fibrillation 12.55 9.34 9 136190 595 90491653
Heat illness 12.54 9.34 7 136192 298 90491950
Total lung capacity increased 12.49 9.34 25 136174 4996 90487252
Meniere's disease 12.44 9.34 6 136193 188 90492060
Haemorrhage subcutaneous 12.42 9.34 20 136179 3376 90488872
Perihepatic discomfort 12.36 9.34 3 136196 9 90492239
Peritoneal haematoma 12.35 9.34 5 136194 102 90492146
Poikiloderma 12.27 9.34 7 136192 311 90491937
Cardiac myxoma 12.25 9.34 7 136192 312 90491936
Stress cardiomyopathy 12.23 9.34 46 136153 13309 90478939
Iron binding capacity total decreased 12.19 9.34 8 136191 458 90491790
Diastolic dysfunction 12.08 9.34 31 136168 7302 90484946
Nephrotic syndrome 12.07 9.34 31 136168 7308 90484940
Brain stem haemorrhage 12.05 9.34 10 136189 821 90491427
Prosthesis implantation 12.04 9.34 5 136194 109 90492139
Histiocytic necrotising lymphadenitis 11.97 9.34 4 136195 46 90492202
Bezold-Jarisch reflex 11.97 9.34 4 136195 46 90492202
Adenocarcinoma 11.93 9.34 19 136180 3177 90489071
Cholecystitis 11.90 9.34 54 136145 16986 90475262
Gingivitis 11.88 9.34 36 136163 9333 90482915
Abdominal pain 11.85 9.34 717 135482 395004 90097244
Brain neoplasm 11.84 9.34 24 136175 4840 90487408
Paraesthesia 11.83 9.34 286 135913 250040 90242208
Glomerulonephritis rapidly progressive 11.81 9.34 12 136187 1278 90490970
Invasive ductal breast carcinoma 11.81 9.34 32 136167 7786 90484462
Renal cancer 11.80 9.34 27 136172 5918 90486330
Large intestinal ulcer haemorrhage 11.79 9.34 5 136194 115 90492133
Cutaneous listeriosis 11.75 9.34 4 136195 49 90492199
Swollen tongue 11.71 9.34 113 136086 45843 90446405
Mental impairment 11.69 9.34 53 136146 16667 90475581
Stool analysis abnormal 11.67 9.34 4 136195 50 90492198
Therapeutic response decreased 11.58 9.34 83 136116 89646 90402602
Rotator cuff syndrome 11.53 9.34 51 136148 15868 90476380
Hypovolaemia 11.53 9.34 43 136156 12388 90479860
Blood potassium decreased 11.50 9.34 116 136083 47611 90444637
Hepatic cytolysis 11.40 9.34 18 136181 30898 90461350
Varicose vein ruptured 11.39 9.34 4 136195 54 90492194
Pancreatic carcinoma 11.39 9.34 33 136166 8344 90483904
Micturition urgency 11.39 9.34 40 136159 11193 90481055
Glomerulosclerosis 11.39 9.34 8 136191 512 90491736
Glucose tolerance impaired 11.39 9.34 32 136167 7953 90484295
Amyotrophic lateral sclerosis 11.37 9.34 12 136187 1336 90490912
Atypical mycobacterial lower respiratory tract infection 11.37 9.34 6 136193 228 90492020
Sputum purulent 11.34 9.34 12 136187 1340 90490908
Muscle atrophy 11.33 9.34 33 136166 8368 90483880
Mesothelioma malignant 11.26 9.34 4 136195 56 90492192
Idiopathic angioedema 11.26 9.34 4 136195 56 90492192
Death 11.24 9.34 566 135633 455985 90036263
Calcium ionised increased 11.23 9.34 6 136193 234 90492014
Haematocrit decreased 11.22 9.34 104 136095 41728 90450520
Sudden death 11.20 9.34 39 136160 10870 90481378
Liver iron concentration abnormal 11.13 9.34 4 136195 58 90492190
Hepatic mass 11.11 9.34 15 136184 2162 90490086
Pleural effusion 11.11 9.34 233 135966 111758 90380490
Gastric ulcer 11.09 9.34 75 136124 27373 90464875
Ankylosing spondylitis 11.09 9.34 3 136196 13130 90479118
Fracture pain 11.08 9.34 11 136188 1140 90491108
Intracranial aneurysm 11.07 9.34 22 136177 4376 90487872
Sensitivity to weather change 11.07 9.34 34 136165 8880 90483368
Pulmonary congestion 11.00 9.34 58 136141 19375 90472873
Laryngeal pain 10.98 9.34 22 136177 4400 90487848
Listeria sepsis 10.97 9.34 9 136190 727 90491521
Blood immunoglobulin E increased 10.97 9.34 22 136177 4403 90487845
Vasoplegia syndrome 10.88 9.34 17 136182 2797 90489451
Transferrin decreased 10.82 9.34 7 136192 391 90491857
Microalbuminuria 10.79 9.34 8 136191 557 90491691
Osteonecrosis 10.78 9.34 72 136127 26169 90466079
Psychotic disorder 10.76 9.34 19 136180 31211 90461037
Malignant hypertension 10.64 9.34 11 136188 1196 90491052
Hepatic cancer 10.62 9.34 23 136176 4858 90487390
Aortic valve sclerosis 10.62 9.34 11 136188 1199 90491049
Microangiopathy 10.61 9.34 13 136186 1702 90490546
Dysaesthesia 10.58 9.34 24 136175 5231 90487017
Sedation 10.56 9.34 37 136162 48134 90444114
Malignant peritoneal neoplasm 10.54 9.34 9 136190 769 90491479
Fixed eruption 10.52 9.34 13 136186 1717 90490531
Calcium metabolism disorder 10.47 9.34 5 136194 153 90492095
Arteriosclerosis coronary artery 10.44 9.34 35 136164 9568 90482680
Infective exacerbation of chronic obstructive airways disease 10.41 9.34 12 136187 1474 90490774
Carotid arteriosclerosis 10.39 9.34 11 136188 1229 90491019
Urine output decreased 10.39 9.34 42 136157 12561 90479687
Diverticulum intestinal haemorrhagic 10.34 9.34 13 136186 1748 90490500
Skin induration 10.32 9.34 18 136181 3244 90489004
Ventricular tachycardia 10.28 9.34 68 136131 24640 90467608
Retinal pigment epitheliopathy 10.27 9.34 6 136193 279 90491969
Shock haemorrhagic 10.25 9.34 41 136158 12204 90480044
Myelodysplastic syndrome 10.24 9.34 60 136139 20843 90471405
Status epilepticus 10.24 9.34 8 136191 18866 90473382
Hypersensitivity pneumonitis 10.24 9.34 20 136179 3928 90488320
Personality disorder 10.21 9.34 3 136196 12441 90479807
Degenerative bone disease 10.21 9.34 6 136193 282 90491966
Generalised oedema 10.20 9.34 56 136143 18997 90473251
Gait disturbance 10.19 9.34 484 135715 260012 90232236
Blood loss anaemia 10.19 9.34 36 136163 10104 90482144
Hydrothorax 10.18 9.34 10 136189 1023 90491225
Electrocardiogram ST segment depression 10.15 9.34 18 136181 3285 90488963
Marasmus 10.10 9.34 9 136190 814 90491434
Shock 10.10 9.34 76 136123 28702 90463546
Forearm fracture 10.08 9.34 8 136191 617 90491631
Disorientation 10.05 9.34 106 136093 44008 90448240
Pancreatic carcinoma metastatic 10.04 9.34 15 136184 2373 90489875
Mydriasis 10.03 9.34 5 136194 15007 90477241
Chest X-ray abnormal 9.99 9.34 23 136176 5059 90487189
Blood glucose fluctuation 9.99 9.34 23 136176 5060 90487188
Hepatic steatosis 9.99 9.34 92 136107 36853 90455395
Thyroid neoplasm 9.98 9.34 20 136179 4001 90488247
Aortic valve calcification 9.98 9.34 8 136191 626 90491622
Protein urine present 9.97 9.34 28 136171 6956 90485292
Intervertebral disc disorder 9.97 9.34 24 136175 5436 90486812
Intentional self-injury 9.96 9.34 18 136181 29316 90462932
Renal hypertension 9.96 9.34 5 136194 171 90492077
Haemorrhagic tumour necrosis 9.95 9.34 3 136196 24 90492224
Primary hyperaldosteronism 9.95 9.34 4 136195 80 90492168
Pelvic floor repair 9.95 9.34 3 136196 24 90492224
Blood parathyroid hormone decreased 9.93 9.34 3 136196 12213 90480035
Ectopic ACTH syndrome 9.91 9.34 5 136194 173 90492075
Aortic dissection 9.91 9.34 15 136184 2402 90489846
Pustular psoriasis 9.90 9.34 8 136191 18548 90473700
Urinary incontinence 9.88 9.34 93 136106 37473 90454775
Electrocardiogram abnormal 9.87 9.34 36 136163 10262 90481986
Fistula discharge 9.85 9.34 10 136189 1065 90491183
Unresponsive to stimuli 9.84 9.34 94 136105 38027 90454221
Cardio-respiratory distress 9.83 9.34 5 136194 176 90492072
PO2 decreased 9.81 9.34 12 136187 1569 90490679
Spondylolisthesis 9.80 9.34 20 136179 4055 90488193
Wrong patient 9.79 9.34 9 136190 848 90491400
Foetal death 9.79 9.34 10 136189 20713 90471535
Dyspnoea at rest 9.77 9.34 22 136177 4769 90487479
Therapeutic drug monitoring analysis not performed 9.77 9.34 11 136188 1318 90490930
Sciatic nerve neuropathy 9.72 9.34 7 136192 466 90491782
Subdural haemorrhage 9.69 9.34 18 136181 3405 90488843
Lichen planus 9.62 9.34 16 136183 2775 90489473
Vascular device infection 9.59 9.34 3 136196 11949 90480299
Product dose omission in error 9.56 9.34 10 136189 20493 90471755
Gastroduodenal haemorrhage 9.56 9.34 4 136195 89 90492159
Adenocarcinoma of colon 9.55 9.34 16 136183 2790 90489458
Postural tremor 9.55 9.34 7 136192 479 90491769
Joint destruction 9.54 9.34 4 136195 13283 90478965
Presyncope 9.53 9.34 81 136118 31724 90460524
Musculoskeletal discomfort 9.49 9.34 59 136140 20932 90471316
Breath sounds abnormal 9.46 9.34 47 136152 15339 90476909
Nephropathy 9.46 9.34 33 136166 9202 90483046
Hyperkinesia 9.46 9.34 13 136186 1906 90490342
Escherichia infection 9.39 9.34 48 136151 15847 90476401
Panniculitis 9.38 9.34 5 136194 14453 90477795
Injection site vesicles 9.38 9.34 20 136179 4180 90488068
Sudden cardiac death 9.36 9.34 14 136185 2218 90490030
Aphasia 9.35 9.34 102 136097 42710 90449538

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 368.91 10.52 526 93553 637809 41889447
Blood pressure inadequately controlled 230.66 10.52 117 93962 2751 42524505
Blood pressure increased 208.39 10.52 594 93485 101334 42425922
Drug ineffective 197.98 10.52 722 93357 629475 41897781
Drug abuse 165.02 10.52 19 94060 104752 42422504
Hyperkalaemia 156.77 10.52 461 93618 79997 42447259
Blood creatinine increased 149.64 10.52 558 93521 109445 42417811
Myocardial infarction 135.07 10.52 587 93492 123422 42403834
Cerebral infarction 125.09 10.52 237 93842 30932 42496324
Acute kidney injury 119.19 10.52 1286 92793 366051 42161205
Death 114.40 10.52 594 93485 470591 42056665
Cardiac failure 114.18 10.52 503 93576 106353 42420903
Blood urea increased 103.82 10.52 226 93853 32567 42494689
Febrile neutropenia 99.72 10.52 160 93919 185543 42341713
Renal failure 98.11 10.52 597 93482 143129 42384127
Dizziness 92.78 10.52 898 93181 248356 42278900
Product use in unapproved indication 91.63 10.52 167 93912 184289 42342967
Syncope 90.77 10.52 447 93632 98959 42428297
Toxicity to various agents 87.24 10.52 240 93839 228896 42298360
Renal impairment 81.06 10.52 467 93612 109761 42417495
Hypertensive crisis 77.65 10.52 104 93975 10102 42517154
Cardiac failure congestive 76.76 10.52 383 93696 85219 42442037
Cerebrovascular accident 74.97 10.52 417 93662 96743 42430513
Cardiac failure chronic 74.83 10.52 99 93980 9502 42517754
Nodular melanoma 72.70 10.52 24 94055 173 42527083
Angina pectoris 72.32 10.52 197 93882 32699 42494557
Neutropenia 71.41 10.52 215 93864 199216 42328040
Disease progression 71.37 10.52 130 93949 143526 42383730
Product dose omission issue 68.68 10.52 149 93930 154216 42373040
Acute myocardial infarction 65.28 10.52 278 93801 57887 42469369
Treatment failure 62.46 10.52 30 94049 62594 42464662
Condition aggravated 61.77 10.52 331 93748 260423 42266833
Angioedema 61.48 10.52 220 93859 42257 42484999
Hypotension 59.13 10.52 846 93233 256785 42270471
Glomerular filtration rate decreased 55.56 10.52 116 93963 16235 42511021
Mitral valve incompetence 54.89 10.52 116 93963 16373 42510883
Completed suicide 54.71 10.52 80 93999 96385 42430871
Drug ineffective for unapproved indication 54.49 10.52 17 94062 46146 42481110
Fear of disease 53.37 10.52 21 94058 263 42526993
Coronary artery disease 52.92 10.52 247 93832 53473 42473783
Blood creatine phosphokinase increased 52.67 10.52 229 93850 48109 42479147
Interstitial lung disease 52.25 10.52 324 93755 78138 42449118
BRASH syndrome 51.32 10.52 38 94041 1787 42525469
Myelosuppression 51.29 10.52 13 94066 40448 42486808
Hospitalisation 51.25 10.52 53 94026 74277 42452979
Eosinophilic colitis 51.20 10.52 21 94058 295 42526961
Sprue-like enteropathy 50.88 10.52 26 94053 621 42526635
Atrial fibrillation 46.08 10.52 491 93588 139102 42388154
Oedema peripheral 45.09 10.52 479 93600 135597 42391659
Chronic kidney disease 44.91 10.52 215 93864 47026 42480230
Blood lactic acid 42.83 10.52 19 94060 327 42526929
Blood pressure decreased 42.74 10.52 247 93832 58085 42469171
Lymphocyte stimulation test positive 42.59 10.52 23 94056 617 42526639
Product use issue 42.21 10.52 65 94014 76686 42450570
Blood potassium increased 40.72 10.52 111 93968 18425 42508831
Gamma-glutamyltransferase increased 39.33 10.52 159 93920 32338 42494918
Blood glucose increased 39.26 10.52 288 93791 73411 42453845
Aortic aneurysm 39.06 10.52 65 94014 7658 42519598
Bundle branch block left 38.95 10.52 59 94020 6417 42520839
Drug intolerance 38.83 10.52 74 94005 80350 42446906
Sedation 38.23 10.52 10 94069 30465 42496791
Sepsis 36.37 10.52 274 93805 199060 42328196
Cerebral haemorrhage 36.07 10.52 176 93903 38790 42488466
Arrhythmia 35.83 10.52 180 93899 40137 42487119
Drug dependence 35.64 10.52 10 94069 29084 42498172
Product impurity 35.38 10.52 10 94069 39 42527217
Oxygen saturation increased 35.32 10.52 16 94063 290 42526966
Adrenal adenoma 34.90 10.52 19 94060 518 42526738
Chronic pigmented purpura 34.80 10.52 13 94066 140 42527116
COVID-19 34.66 10.52 135 93944 115813 42411443
Peripheral arterial occlusive disease 33.84 10.52 57 94022 6781 42520475
Loss of personal independence in daily activities 33.79 10.52 36 94043 49780 42477476
Fractured coccyx 33.03 10.52 13 94066 163 42527093
Rhabdomyolysis 32.38 10.52 288 93791 77731 42449525
Lymphocyte count 32.37 10.52 14 94065 226 42527030
Type 2 diabetes mellitus 32.32 10.52 102 93977 18369 42508887
Blood pressure diastolic decreased 32.25 10.52 71 94008 10304 42516952
Hemiplegia 31.70 10.52 60 94019 7819 42519437
Brain natriuretic peptide abnormal 31.62 10.52 16 94063 374 42526882
Intentional product use issue 31.37 10.52 70 94009 71763 42455493
Pancreatic neoplasm 31.32 10.52 22 94057 952 42526304
Chest pain 31.05 10.52 456 93623 139074 42388182
Myocardial ischaemia 31.01 10.52 98 93981 17664 42509592
Blood pressure systolic decreased 30.80 10.52 46 94033 4941 42522315
Malignant neoplasm progression 30.64 10.52 129 93950 108271 42418985
Therapy partial responder 30.59 10.52 4 94075 20017 42507239
Left ventricular dilatation 30.38 10.52 21 94058 885 42526371
Hyponatraemia 30.31 10.52 350 93729 101112 42426144
Pemphigoid 29.65 10.52 73 94006 11394 42515862
Haemophagocytic lymphohistiocytosis 29.44 10.52 3 94076 18219 42509037
Clostridium difficile infection 29.26 10.52 7 94072 22652 42504604
N-terminal prohormone brain natriuretic peptide abnormal 29.08 10.52 13 94066 228 42527028
Cell marker increased 29.07 10.52 16 94063 446 42526810
Blood triglycerides increased 28.94 10.52 89 93990 15807 42511449
Periarthritis calcarea 28.76 10.52 10 94069 86 42527170
Chest injury 28.44 10.52 27 94052 1795 42525461
Infusion related reaction 28.43 10.52 57 94022 60749 42466507
Articular calcification 28.36 10.52 10 94069 90 42527166
Ventricular extrasystoles 28.24 10.52 79 94000 13311 42513945
Suicidal ideation 28.22 10.52 39 94040 48122 42479134
Foetal exposure during pregnancy 28.04 10.52 38 94041 47273 42479983
Gastritis erosive 28.02 10.52 51 94028 6452 42520804
Pulmonary valve stenosis congenital 28.01 10.52 11 94068 137 42527119
Cytopenia 27.96 10.52 3 94076 17494 42509762
Aggression 27.69 10.52 34 94045 44129 42483127
Thrombotic stroke 27.53 10.52 13 94066 260 42526996
Painful respiration 26.71 10.52 23 94056 1346 42525910
Colon cancer 26.49 10.52 63 94016 9618 42517638
Intentional product misuse 26.47 10.52 61 94018 61839 42465417
Therapeutic product effect incomplete 26.41 10.52 75 94004 70864 42456392
Coronary arterial stent insertion 26.41 10.52 38 94041 3947 42523309
Melaena 26.40 10.52 161 93918 38585 42488671
Cardiac failure acute 26.40 10.52 78 94001 13555 42513701
Sinus arrest 26.38 10.52 28 94051 2128 42525128
Orthostatic intolerance 26.22 10.52 19 94060 864 42526392
Conduction disorder 26.14 10.52 30 94049 2488 42524768
Lymphocyte count abnormal 26.05 10.52 28 94051 2159 42525097
Hyperglycaemia 26.03 10.52 182 93897 45677 42481579
Ejection fraction decreased 25.88 10.52 107 93972 21980 42505276
Gastric cancer 25.86 10.52 51 94028 6852 42520404
Loss of consciousness 25.56 10.52 314 93765 92040 42435216
Physical deconditioning 25.55 10.52 29 94050 2376 42524880
Dyslipidaemia 25.46 10.52 61 94018 9357 42517899
Aortic valve incompetence 25.28 10.52 49 94030 6499 42520757
Shock 25.16 10.52 129 93950 28992 42498264
Bradycardia 25.13 10.52 294 93785 85190 42442066
Mucosal inflammation 25.10 10.52 44 94035 49330 42477926
Hypoglycaemia 24.86 10.52 221 93858 59633 42467623
Pulmonary arterial pressure abnormal 24.83 10.52 13 94066 327 42526929
Psychotic disorder 24.82 10.52 17 94062 29191 42498065
Cerebellar ischaemia 24.67 10.52 10 94069 136 42527120
Goitre 24.61 10.52 25 94054 1805 42525451
Cytokine release syndrome 24.19 10.52 38 94041 44489 42482767
Arteriosclerosis 24.19 10.52 91 93988 17898 42509358
Microalbuminuria 24.13 10.52 18 94061 856 42526400
Status epilepticus 24.07 10.52 3 94076 15575 42511681
Drug resistance 24.07 10.52 24 94055 34224 42493032
Ejection fraction abnormal 23.74 10.52 21 94058 1274 42525982
Neuropathy peripheral 23.66 10.52 130 93949 101723 42425533
Breast discomfort 23.52 10.52 6 94073 14 42527242
Pancytopenia 23.32 10.52 158 93921 117585 42409671
Intentional self-injury 23.32 10.52 3 94076 15199 42512057
Coronary artery restenosis 23.27 10.52 18 94061 904 42526352
Glycosylated haemoglobin increased 23.20 10.52 72 94007 12852 42514404
Blood thyroid stimulating hormone abnormal 22.67 10.52 13 94066 393 42526863
Coronary artery stenosis 22.64 10.52 62 94017 10317 42516939
Liver function test increased 22.49 10.52 8 94071 19990 42507266
Presyncope 22.08 10.52 103 93976 22284 42504972
Tricuspid valve incompetence 21.91 10.52 64 94015 11049 42516207
Adrenal cyst 21.84 10.52 10 94069 186 42527070
Agitation 21.79 10.52 71 94008 64243 42463013
Hepatitis E antibody positive 21.78 10.52 11 94068 256 42527000
Synovitis 21.76 10.52 4 94075 15563 42511693
Merycism 21.76 10.52 8 94071 82 42527174
Angina unstable 21.69 10.52 65 94014 11383 42515873
Atrioventricular block 21.54 10.52 58 94021 9557 42517699
Renal artery stenosis 21.39 10.52 26 94053 2291 42524965
Patent ductus arteriosus 21.37 10.52 32 94047 3444 42523812
Lipoprotein (a) increased 21.25 10.52 12 94067 352 42526904
Pulmonary embolism 21.04 10.52 166 93913 119446 42407810
Electrocardiogram QRS complex abnormal 21.03 10.52 13 94066 452 42526804
Subacute hepatic failure 20.64 10.52 8 94071 96 42527160
Lateropulsion 20.47 10.52 4 94075 0 42527256
Appendicitis 20.36 10.52 10 94069 20603 42506653
Hepatitis E virus test positive 20.30 10.52 11 94068 297 42526959
Metabolic acidosis 20.27 10.52 189 93890 51669 42475587
Retinopathy 20.10 10.52 25 94054 2256 42525000
Renal cyst 19.97 10.52 58 94021 9981 42517275
Pulmonary hypoplasia 19.84 10.52 13 94066 501 42526755
Lung diffusion disorder 19.77 10.52 9 94070 165 42527091
Idiopathic pulmonary fibrosis 19.70 10.52 36 94043 4568 42522688
Vomiting 19.68 10.52 488 93591 289235 42238021
Fear 19.60 10.52 61 94018 10904 42516352
Post streptococcal glomerulonephritis 19.59 10.52 8 94071 111 42527145
Bacteraemia 19.45 10.52 16 94063 25024 42502232
Therapy non-responder 19.43 10.52 57 94022 53302 42473954
Bundle branch block right 19.28 10.52 50 94029 8056 42519200
Angioplasty 19.28 10.52 17 94062 1027 42526229
Quality of life decreased 19.27 10.52 39 94040 5337 42521919
Blood pressure abnormal 19.16 10.52 57 94022 9941 42517315
Nephrogenic anaemia 19.13 10.52 26 94053 2560 42524696
Deep vein thrombosis 19.11 10.52 96 93983 76861 42450395
Rhythm idioventricular 18.90 10.52 11 94068 342 42526914
Emotional distress 18.88 10.52 78 94001 16015 42511241
Diabetes mellitus 18.71 10.52 209 93870 59878 42467378
Immature granulocyte count increased 18.69 10.52 10 94069 263 42526993
Lacunar infarction 18.62 10.52 29 94050 3231 42524025
Atrioventricular block first degree 18.59 10.52 43 94036 6448 42520808
Renal failure neonatal 18.51 10.52 8 94071 129 42527127
Renal hypertrophy 18.45 10.52 6 94073 41 42527215
Protein urine present 18.37 10.52 40 94039 5761 42521495
Hyperuricaemia 18.32 10.52 54 94025 9370 42517886
Incorrect route of product administration 18.30 10.52 16 94063 24289 42502967
Septic shock 18.15 10.52 123 93956 91549 42435707
Thrombocytopenia 18.14 10.52 303 93776 189976 42337280
Hypertrophic osteoarthropathy 18.13 10.52 7 94072 83 42527173
Lower respiratory tract infection 18.11 10.52 40 94039 41166 42486090
Diabetic nephropathy 18.03 10.52 24 94055 2317 42524939
Ventricular hypokinesia 17.98 10.52 44 94035 6840 42520416
Erectile dysfunction 17.92 10.52 105 93974 24808 42502448
Carotid artery stenosis 17.81 10.52 38 94041 5398 42521858
Extrapyramidal disorder 17.72 10.52 7 94072 16405 42510851
Product substitution issue 17.65 10.52 60 94019 11230 42516026
Osteoarthritis 17.64 10.52 103 93976 24302 42502954
Brain stem infarction 17.58 10.52 18 94061 1312 42525944
Ischaemic stroke 17.50 10.52 96 93983 22137 42505119
Cardiovascular disorder 17.47 10.52 67 94012 13298 42513958
Ventricular hypertrophy 17.34 10.52 35 94044 4781 42522475
Gouty arthritis 16.94 10.52 17 94062 1210 42526046
Aneurysm 16.89 10.52 22 94057 2079 42525177
Generalised tonic-clonic seizure 16.86 10.52 20 94059 26359 42500897
Non-cardiogenic pulmonary oedema 16.82 10.52 15 94064 920 42526336
Coronary artery occlusion 16.80 10.52 58 94021 10939 42516317
Dyspnoea exertional 16.80 10.52 177 93902 49971 42477285
Adverse drug reaction 16.73 10.52 36 94043 37398 42489858
Cardiac vein perforation 16.69 10.52 5 94074 25 42527231
Pericardial haemorrhage 16.67 10.52 29 94050 3540 42523716
Electrocardiogram ST segment depression 16.55 10.52 25 94054 2712 42524544
Diastolic dysfunction 16.53 10.52 43 94036 6940 42520316
Sleep disorder due to a general medical condition 16.44 10.52 9 94070 17444 42509812
Transient ischaemic attack 16.36 10.52 129 93950 33610 42493646
Bile duct cancer 16.35 10.52 13 94066 680 42526576
Dyspnoea 16.34 10.52 1160 92919 441461 42085795
Inguinal hernia 16.32 10.52 50 94029 8862 42518394
Renal cell carcinoma 16.30 10.52 37 94042 5480 42521776
Blood lactate dehydrogenase increased 16.29 10.52 106 93973 25975 42501281
Pneumonia 16.26 10.52 764 93315 421385 42105871
Hypertensive heart disease 16.22 10.52 24 94055 2556 42524700
Injection site pain 16.19 10.52 69 94010 57729 42469527
Respiratory depression 16.01 10.52 11 94068 18857 42508399
Nightmare 15.95 10.52 19 94060 24993 42502263
Walking aid user 15.85 10.52 24 94055 2609 42524647
Hypoparathyroidism 15.83 10.52 13 94066 712 42526544
Myosclerosis 15.78 10.52 9 94070 269 42526987
Full blood count abnormal 15.76 10.52 26 94053 29850 42497406
Atrial thrombosis 15.75 10.52 23 94056 2421 42524835
Haematocrit decreased 15.59 10.52 131 93948 34777 42492479
Activated partial thromboplastin time shortened 15.56 10.52 11 94068 481 42526775
Surfactant protein increased 15.48 10.52 4 94075 10 42527246
Blepharochalasis 15.36 10.52 3 94076 0 42527256
Bursitis 15.35 10.52 39 94040 6205 42521051
Cytomegalovirus infection 15.34 10.52 30 94049 32276 42494980
Concomitant disease progression 15.33 10.52 23 94056 2480 42524776
Lactic acidosis 15.28 10.52 160 93919 45101 42482155
Ischaemic cardiomyopathy 15.28 10.52 40 94039 6482 42520774
Dyslalia 15.17 10.52 12 94067 623 42526633
Carotid arteriosclerosis 15.11 10.52 22 94057 2310 42524946
Hyperphosphataemia 14.97 10.52 5 94074 12999 42514257
Pyonephrosis 14.96 10.52 7 94072 137 42527119
Oedema 14.90 10.52 178 93901 51823 42475433
Osteochondrosis 14.90 10.52 17 94062 1401 42525855
Atrioventricular block complete 14.88 10.52 57 94022 11307 42515949
Graft versus host disease 14.83 10.52 5 94074 12920 42514336
Renal dysplasia 14.80 10.52 8 94071 215 42527041
Acquired C1 inhibitor deficiency 14.71 10.52 4 94075 13 42527243
Colitis 14.70 10.52 53 94026 46519 42480737
Superficial spreading melanoma stage I 14.69 10.52 5 94074 40 42527216
Nephrocalcinosis 14.68 10.52 13 94066 790 42526466
Urine albumin/creatinine ratio increased 14.67 10.52 11 94068 527 42526729
Cardiac pacemaker insertion 14.67 10.52 26 94053 3222 42524034
Allergic oedema 14.65 10.52 6 94073 84 42527172
Bronchitis 14.61 10.52 164 93915 47037 42480219
Dystonia 14.58 10.52 5 94074 12785 42514471
Orthopnoea 14.55 10.52 35 94044 5382 42521874
Hypophosphataemia 14.35 10.52 15 94064 20930 42506326
Urticaria chronic 14.34 10.52 7 94072 151 42527105
Transplant rejection 14.34 10.52 6 94073 13582 42513674
Eyelid ptosis congenital 14.21 10.52 6 94073 91 42527165
Diabetic retinopathy 14.15 10.52 20 94059 2043 42525213
Proteinuria 14.10 10.52 93 93986 22890 42504366
Miosis 14.09 10.52 6 94073 13440 42513816
Influenza 14.08 10.52 80 93999 62095 42465161
Costal cartilage fracture 14.06 10.52 8 94071 238 42527018
Neurotoxicity 14.01 10.52 19 94060 23632 42503624
Hepatic calcification 13.97 10.52 9 94070 337 42526919
Pancreatitis chronic 13.88 10.52 21 94058 2281 42524975
Intermittent claudication 13.85 10.52 22 94057 2493 42524763
Vertigo 13.84 10.52 126 93953 34221 42493035
Cytomegalovirus viraemia 13.81 10.52 3 94076 10374 42516882
Illness 13.81 10.52 21 94058 24909 42502347
Lip oedema 13.75 10.52 25 94054 3159 42524097
Drug use disorder 13.73 10.52 3 94076 10330 42516926
Disease recurrence 13.72 10.52 28 94051 29650 42497606
Venoocclusive liver disease 13.67 10.52 3 94076 10299 42516957
Pyrexia 13.64 10.52 721 93358 393321 42133935
Decreased appetite 13.56 10.52 538 93541 192599 42334657
Paranoia 13.56 10.52 7 94072 14019 42513237
Leukopenia 13.48 10.52 103 93976 74643 42452613
Carcinoid tumour 13.40 10.52 8 94071 261 42526995
Extrasystoles 13.30 10.52 29 94050 4180 42523076
Legionella test positive 13.28 10.52 3 94076 3 42527253
Haemangioma 13.26 10.52 19 94060 1966 42525290
Left ventricular hypertrophy 13.25 10.52 48 94031 9271 42517985
Stress urinary incontinence 13.23 10.52 6 94073 109 42527147
Lipid metabolism disorder 13.20 10.52 10 94069 487 42526769
Anhedonia 13.19 10.52 42 94037 7598 42519658
Product residue present 13.16 10.52 23 94056 2818 42524438
Nodal rhythm 13.11 10.52 17 94062 1600 42525656
Malignant melanoma 13.01 10.52 48 94031 9352 42517904
Oedema neonatal 12.89 10.52 4 94075 23 42527233
Frequent bowel movements 12.88 10.52 17 94062 21390 42505866
Accidental overdose 12.86 10.52 27 94052 28303 42498953
Hepatic function abnormal 12.85 10.52 172 93907 51395 42475861
Seizure 12.82 10.52 188 93891 120373 42406883
Thalamus haemorrhage 12.76 10.52 14 94065 1105 42526151
Chest discomfort 12.63 10.52 204 93875 63412 42463844
Neutropenic sepsis 12.62 10.52 10 94069 15936 42511320
Distributive shock 12.61 10.52 21 94058 2475 42524781
Coronary angioplasty 12.56 10.52 9 94070 402 42526854
Sacroiliac joint dysfunction 12.49 10.52 6 94073 125 42527131
Blood alkaline phosphatase increased 12.41 10.52 121 93958 33476 42493780
Bacterial infection 12.30 10.52 27 94052 27852 42499404
Acute coronary syndrome 12.25 10.52 65 94014 14800 42512456
Erythema multiforme 12.21 10.52 49 94030 9928 42517328
Pathogen resistance 12.17 10.52 5 94074 11445 42515811
Sense of oppression 12.16 10.52 10 94069 549 42526707
Adrenomegaly 12.12 10.52 9 94070 425 42526831
Tonic clonic movements 12.07 10.52 15 94064 1352 42525904
Miscarriage of partner 12.07 10.52 3 94076 6 42527250
Psoriatic arthropathy 12.02 10.52 23 94056 24944 42502312
Drug hypersensitivity 12.00 10.52 151 93928 99238 42428018
Hallucination 11.97 10.52 76 94003 57431 42469825
No adverse event 11.93 10.52 45 94034 38976 42488280
Renal embolism 11.91 10.52 6 94073 139 42527117
Left atrial enlargement 11.89 10.52 13 94066 1022 42526234
Abdominal tenderness 11.87 10.52 30 94049 4759 42522497
Hepatic cytolysis 11.84 10.52 26 94053 26818 42500438
Cold sweat 11.82 10.52 53 94026 11277 42515979
Injury 11.75 10.52 87 93992 22229 42505027
Hypoxia 11.74 10.52 98 93981 69688 42457568
Impaired work ability 11.74 10.52 6 94073 12085 42515171
Ocular icterus 11.72 10.52 23 94056 3078 42524178
Haemorrhage subcutaneous 11.72 10.52 21 94058 2625 42524631
Glomerulonephritis acute 11.71 10.52 6 94073 144 42527112
Low density lipoprotein increased 11.69 10.52 32 94047 5323 42521933
Blood creatinine 11.66 10.52 5 94074 79 42527177
Chest wall haematoma 11.65 10.52 7 94072 231 42527025
Manufacturing materials contamination 11.65 10.52 4 94075 33 42527223
Metamyelocyte count increased 11.52 10.52 9 94070 459 42526797
Abdominal distension 11.50 10.52 102 93977 71633 42455623
Blood pressure systolic increased 11.47 10.52 103 93976 27865 42499391
Lipase increased 11.46 10.52 50 94029 10516 42516740
Chondrocalcinosis pyrophosphate 11.39 10.52 12 94067 904 42526352
Abnormal behaviour 11.36 10.52 26 94053 26425 42500831
Papillary renal cell carcinoma 11.35 10.52 8 94071 348 42526908
Hypertension 11.33 10.52 464 93615 166740 42360516
Aspartate aminotransferase increased 11.31 10.52 236 93843 76927 42450329
Device issue 11.30 10.52 8 94071 13501 42513755
Anaemia 11.27 10.52 740 93339 279538 42247718
Product monitoring error 11.27 10.52 28 94051 4395 42522861
Aspergillus infection 11.24 10.52 11 94068 15826 42511430
Blood cholesterol increased 11.23 10.52 99 93980 26642 42500614
Abdominal compartment syndrome 11.19 10.52 13 94066 1092 42526164
Malaise 11.18 10.52 574 93505 211582 42315674
Neutrophil count decreased 11.15 10.52 88 93991 63327 42463929
Hot flush 11.13 10.52 86 93993 22265 42504991
Blood cholesterol decreased 11.12 10.52 13 94066 1100 42526156
Coordination abnormal 11.05 10.52 41 94038 8009 42519247
Nephropathy 11.04 10.52 37 94042 6874 42520382
Aortic aneurysm rupture 11.02 10.52 13 94066 1110 42526146
Lower respiratory tract inflammation 11.02 10.52 5 94074 91 42527165
Small intestinal haemorrhage 10.99 10.52 19 94060 2309 42524947
Hallucination, auditory 10.93 10.52 10 94069 14854 42512402
Neuromyopathy 10.92 10.52 13 94066 1121 42526135
Feeling cold 10.88 10.52 57 94022 12916 42514340
Pain 10.88 10.52 436 93643 244412 42282844
Genital candidiasis 10.87 10.52 5 94074 94 42527162
Peripheral vascular disorder 10.85 10.52 31 94048 5286 42521970
Creatinine urine increased 10.82 10.52 7 94072 264 42526992
Blast cells present 10.79 10.52 9 94070 504 42526752
Bronchoscopy 10.71 10.52 4 94075 43 42527213
Paralysis 10.70 10.52 37 94042 6983 42520273
Percutaneous coronary intervention 10.70 10.52 7 94072 269 42526987
Hypoventilation 10.68 10.52 25 94054 3777 42523479
Congenital inguinal hernia 10.62 10.52 6 94073 176 42527080
Pneumocystis jirovecii pneumonia 10.61 10.52 25 94054 25156 42502100
Anuria 10.60 10.52 52 94027 11480 42515776
Major depression 10.56 10.52 31 94048 5367 42521889
C-reactive protein increased 10.53 10.52 198 93881 63362 42463894

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 453.03 9.74 2138 177737 633292 109776132
Blood pressure inadequately controlled 419.23 9.74 218 179657 7415 110402009
Hyperkalaemia 413.29 9.74 770 179105 135026 110274398
Cardiac failure congestive 412.69 9.74 818 179057 150182 110259242
Off label use 387.75 9.74 1207 178668 1498978 108910446
Blood pressure increased 371.32 9.74 1091 178784 257282 110152142
Myocardial infarction 366.68 9.74 901 178974 191182 110218242
Hyponatraemia 358.75 9.74 966 178909 216687 110192737
Hand deformity 321.25 9.74 7 179868 218499 110190925
Glossodynia 289.44 9.74 18 179857 221986 110187438
Systemic lupus erythematosus 282.98 9.74 39 179836 254299 110155125
Pemphigus 272.12 9.74 20 179855 214550 110194874
Duodenal ulcer perforation 260.01 9.74 6 179869 177694 110231730
Anti-cyclic citrullinated peptide antibody positive 255.79 9.74 9 179866 181975 110227449
Syncope 232.77 9.74 792 179083 201744 110207680
Renal failure 232.06 9.74 853 179022 225721 110183703
Pericarditis 231.39 9.74 39 179836 219075 110190349
Coronary artery disease 226.15 9.74 413 179462 71277 110338147
Helicobacter infection 224.88 9.74 19 179856 181858 110227566
Cerebral infarction 222.79 9.74 343 179532 51495 110357929
Hypotension 219.56 9.74 1531 178344 522318 109887106
Folliculitis 214.37 9.74 15 179860 167638 110241786
Blood creatinine increased 208.23 9.74 713 179162 182176 110227248
Psoriatic arthropathy 207.80 9.74 35 179840 196726 110212698
Cardiac failure 203.68 9.74 720 179155 186906 110222518
Product use in unapproved indication 196.60 9.74 264 179611 447113 109962311
Wound 196.35 9.74 68 179807 234369 110175055
Hypertensive crisis 193.34 9.74 218 179657 24154 110385270
Maternal exposure during pregnancy 185.87 9.74 91 179784 254792 110154632
Muscle injury 181.77 9.74 12 179863 140795 110268629
Synovitis 178.03 9.74 113 179762 273979 110135445
Renal impairment 174.38 9.74 687 179188 187758 110221666
Alopecia 170.85 9.74 205 179670 364548 110044876
Atrial fibrillation 169.80 9.74 782 179093 228860 110180564
Arthropathy 163.99 9.74 136 179739 287386 110122038
Oedema peripheral 160.84 9.74 999 178876 327661 110081763
Treatment failure 160.77 9.74 129 179746 277105 110132319
Drug intolerance 155.26 9.74 264 179611 406248 110003176
Anaemia 155.16 9.74 1463 178412 545623 109863801
Irritable bowel syndrome 153.21 9.74 39 179836 164176 110245248
Drug ineffective 151.21 9.74 1665 178210 1518875 108890549
Blood glucose increased 151.16 9.74 517 179358 131979 110277445
Sleep disorder due to general medical condition, insomnia type 149.22 9.74 5 179870 105638 110303786
Fibromyalgia 144.08 9.74 49 179826 170860 110238564
Joint swelling 141.93 9.74 319 179556 442526 109966898
Thyroid disorder 141.84 9.74 156 179719 16813 110392611
Acute myocardial infarction 141.05 9.74 375 179500 83402 110326022
Facet joint syndrome 135.31 9.74 5 179870 96823 110312601
Rheumatoid factor positive 133.39 9.74 26 179849 131614 110277810
Cerebrovascular accident 132.24 9.74 615 179260 180669 110228755
Lip dry 130.75 9.74 8 179867 100075 110309349
Cardiac failure chronic 129.60 9.74 135 179740 13676 110395748
Blister 127.86 9.74 109 179766 227267 110182157
Multi-organ disorder 126.48 9.74 75 179800 3306 110406118
Product use issue 124.98 9.74 196 179679 311499 110097925
Blood urea increased 124.65 9.74 276 179599 54681 110354743
Bradycardia 119.68 9.74 536 179339 154981 110254443
Infusion related reaction 119.32 9.74 278 179597 380884 110028540
Mitral valve incompetence 119.30 9.74 203 179672 33126 110376298
Condition aggravated 119.26 9.74 704 179171 734132 109675292
Drug abuse 118.14 9.74 71 179804 177340 110232084
Intentional product use issue 117.45 9.74 138 179737 247768 110161656
Swelling 114.79 9.74 250 179625 350791 110058633
Rhabdomyolysis 113.00 9.74 441 179434 119960 110289464
Dizziness 111.23 9.74 1672 178203 696521 109712903
Oligohydramnios 110.11 9.74 73 179802 3921 110405503
Joint range of motion decreased 109.73 9.74 31 179844 121801 110287623
Therapeutic product effect decreased 107.39 9.74 144 179731 244172 110165252
Completed suicide 106.40 9.74 143 179732 242238 110167186
Stomatitis 105.43 9.74 173 179702 270069 110139355
Blood creatine phosphokinase increased 105.18 9.74 309 179566 72768 110336656
Lower respiratory tract infection 105.13 9.74 145 179730 242961 110166463
Impaired healing 102.64 9.74 101 179774 196616 110212808
Chronic kidney disease 101.71 9.74 314 179561 75977 110333447
Discomfort 101.18 9.74 120 179755 214587 110194837
Exposure during pregnancy 100.72 9.74 75 179800 167349 110242075
Contraindicated product administered 99.61 9.74 156 179719 248111 110161313
Musculoskeletal stiffness 97.61 9.74 192 179683 279630 110129794
Grip strength decreased 97.38 9.74 9 179866 80165 110329259
Gastrointestinal disorder 97.10 9.74 152 179723 241800 110167624
Drug interaction 95.82 9.74 1238 178637 498945 109910479
Febrile neutropenia 95.18 9.74 236 179639 316531 110092893
Angina pectoris 95.05 9.74 269 179606 62026 110347398
Eye haemorrhage 92.84 9.74 105 179770 11669 110397755
Macular degeneration 92.60 9.74 143 179732 21516 110387908
Live birth 92.46 9.74 5 179870 69479 110339945
Migraine 92.03 9.74 86 179789 171566 110237858
C-reactive protein abnormal 90.49 9.74 49 179826 129646 110279778
Liver injury 89.67 9.74 68 179807 150345 110259079
Hypoglycaemia 86.94 9.74 397 179478 115707 110293717
Interstitial lung disease 85.44 9.74 450 179425 138884 110270540
Ill-defined disorder 84.78 9.74 78 179797 156775 110252649
Diabetes mellitus inadequate control 84.51 9.74 164 179711 29611 110379813
Drug ineffective for unapproved indication 84.07 9.74 31 179844 102807 110306617
Hepatic enzyme increased 82.35 9.74 258 179617 320634 110088790
Bronchial neoplasm 80.58 9.74 31 179844 505 110408919
Dehydration 79.82 9.74 749 179126 278762 110130662
Deep vein thrombosis postoperative 79.73 9.74 4 179871 59287 110350137
Bursitis 79.69 9.74 57 179818 129861 110279563
Infection 79.02 9.74 312 179563 361888 110047536
Liver function test increased 78.87 9.74 23 179852 88525 110320899
Angioedema 78.41 9.74 343 179532 98157 110311267
Melaena 77.25 9.74 267 179608 68490 110340934
BRASH syndrome 76.86 9.74 57 179818 3666 110405758
Haematochezia 76.33 9.74 381 179494 115143 110294281
Pulmonary oedema 75.97 9.74 345 179530 100314 110309110
Blood pressure decreased 75.64 9.74 379 179496 114712 110294712
Bundle branch block left 74.12 9.74 98 179777 12790 110396634
Drug hypersensitivity 74.09 9.74 434 179441 453656 109955768
Nasal turbinate hypertrophy 73.31 9.74 33 179842 811 110408613
Night sweats 73.15 9.74 66 179809 133917 110275507
Colitis microscopic 72.68 9.74 99 179776 13295 110396129
Rheumatoid arthritis 72.64 9.74 247 179628 299366 110110058
Sinusitis 72.33 9.74 244 179631 296444 110112980
Paraesthesia oral 71.77 9.74 165 179710 33506 110375918
Nail disorder 71.73 9.74 6 179869 57929 110351495
Death 71.56 9.74 759 179116 698110 109711314
Angina unstable 70.97 9.74 109 179766 16323 110393101
Product prescribing error 70.96 9.74 214 179661 51117 110358307
Myalgia 70.68 9.74 610 179265 221771 110187653
Blepharospasm 69.83 9.74 5 179870 54846 110354578
Chest pain 69.68 9.74 926 178949 375449 110033975
Peripheral venous disease 69.36 9.74 25 179850 84092 110325332
Chronic sinusitis 68.57 9.74 136 179739 24948 110384476
Vaginal flatulence 67.78 9.74 91 179784 12053 110397371
Tricuspid valve incompetence 67.15 9.74 131 179744 23742 110385682
Nodular melanoma 67.11 9.74 23 179852 264 110409160
Myelosuppression 66.75 9.74 35 179840 94305 110315119
Wound infection 66.49 9.74 37 179838 96428 110312996
Lymphatic fistula 66.16 9.74 37 179838 1458 110407966
Femoral hernia incarcerated 65.84 9.74 37 179838 1472 110407952
Rash 65.77 9.74 940 178935 820024 109589400
Cardiovascular disorder 65.37 9.74 126 179749 22634 110386790
Cerebral haemorrhage 65.08 9.74 243 179632 64725 110344699
Sleep disorder 64.45 9.74 142 179733 198502 110210922
Endometrial ablation 63.57 9.74 31 179844 917 110408507
Blood potassium increased 63.37 9.74 156 179719 33093 110376331
Bronchial haemorrhage 63.22 9.74 35 179840 1352 110408072
Blood pressure systolic increased 63.03 9.74 285 179590 82706 110326718
Arrhythmia 62.97 9.74 252 179623 69323 110340101
Mobility decreased 62.23 9.74 189 179686 237233 110172191
Procedural pain 61.68 9.74 161 179714 35404 110374020
Adverse drug reaction 61.29 9.74 49 179826 105510 110303914
Gastrointestinal haemorrhage 61.22 9.74 470 179405 165048 110244376
Toxicity to various agents 61.19 9.74 494 179381 480061 109929363
Diverticulum intestinal 61.15 9.74 85 179790 11634 110397790
Diverticulitis 61.14 9.74 209 179666 53313 110356111
Type 2 diabetes mellitus 60.59 9.74 123 179752 177109 110232315
Female genital tract fistula 59.63 9.74 101 179774 16418 110393006
Hyperglycaemia 59.33 9.74 285 179590 84805 110324619
Adjustment disorder with depressed mood 58.88 9.74 3 179872 43880 110365544
Pregnancy 58.76 9.74 7 179868 51060 110358364
Asthmatic crisis 58.69 9.74 39 179836 2103 110407321
Gamma-glutamyltransferase increased 58.67 9.74 226 179649 61083 110348341
Onychomadesis 58.60 9.74 4 179871 45659 110363765
Fall 58.41 9.74 1338 178537 602144 109807280
Myocardial ischaemia 58.25 9.74 132 179743 26552 110382872
Urticaria 57.89 9.74 294 179581 318563 110090861
Abdominal discomfort 57.74 9.74 389 179486 393469 110015955
Labile hypertension 57.10 9.74 25 179850 574 110408850
Prescribed overdose 56.97 9.74 36 179839 87545 110321879
Pancreatic steatosis 56.86 9.74 36 179839 1786 110407638
Glaucoma 56.70 9.74 118 179757 22399 110387025
Coronary arterial stent insertion 55.83 9.74 58 179817 5857 110403567
Tachyarrhythmia 55.71 9.74 68 179807 8193 110401231
Wound infection pseudomonas 54.51 9.74 39 179836 2372 110407052
Hypersensitivity 54.36 9.74 409 179466 403589 110005835
Lactic acidosis 54.33 9.74 296 179579 92515 110316909
Glomerular filtration rate decreased 54.28 9.74 135 179740 28821 110380603
Loss of consciousness 53.51 9.74 521 179354 195785 110213639
Product impurity 53.03 9.74 15 179860 85 110409339
Radiculopathy 51.85 9.74 104 179771 19232 110390192
Proctitis 51.45 9.74 96 179779 16831 110392593
Disease progression 51.44 9.74 213 179662 243821 110165603
Blood lactate dehydrogenase increased 51.41 9.74 174 179701 44160 110365264
Hepatic cyst 50.77 9.74 63 179812 7720 110401704
Hip arthroplasty 50.63 9.74 14 179861 55799 110353625
Thrombotic stroke 50.55 9.74 25 179850 763 110408661
Hospitalisation 50.33 9.74 97 179778 142396 110267028
Transient ischaemic attack 50.30 9.74 222 179653 63760 110345664
Cardiac failure acute 50.23 9.74 117 179758 23961 110385463
Adverse event 49.98 9.74 62 179813 108747 110300677
Autoimmune disorder 49.83 9.74 22 179853 65461 110343963
Therapy non-responder 49.76 9.74 114 179761 157193 110252231
Lichen planopilaris 49.21 9.74 16 179859 154 110409270
Obesity 48.58 9.74 68 179807 113283 110296141
Arterial haemorrhage 48.36 9.74 44 179831 3775 110405649
Atrioventricular block complete 47.97 9.74 103 179772 19979 110389445
Pain 47.96 9.74 1185 178690 953770 109455654
Arthralgia 47.57 9.74 938 178937 778694 109630730
Injection site reaction 47.29 9.74 45 179830 89025 110320399
Ischaemic stroke 47.01 9.74 161 179714 41102 110368322
Dry mouth 46.98 9.74 167 179708 199781 110209643
Hiatus hernia 46.88 9.74 124 179751 27482 110381942
Hypokalaemia 46.71 9.74 478 179397 181970 110227454
Dyspnoea 46.63 9.74 2223 177652 1104649 109304775
Vaginal discharge 46.45 9.74 95 179780 17813 110391611
Cardiomegaly 45.62 9.74 127 179748 29003 110380421
Renal artery stenosis 45.37 9.74 42 179833 3684 110405740
Weight decreased 45.32 9.74 1038 178837 467019 109942405
Haematoma 45.29 9.74 202 179673 58274 110351150
Lower limb fracture 44.98 9.74 34 179841 75314 110334110
Aortic aneurysm 44.61 9.74 67 179808 9837 110399587
Lung disorder 44.59 9.74 147 179728 179900 110229524
Epilepsy 44.07 9.74 59 179816 100150 110309274
Rhonchi 43.90 9.74 45 179830 4473 110404951
Bronchitis 43.89 9.74 419 179456 156613 110252811
Neutropenia 43.67 9.74 394 179481 374226 110035198
Lymphocyte stimulation test positive 43.67 9.74 25 179850 1031 110408393
Pemphigoid 43.59 9.74 98 179777 19609 110389815
Bronchial disorder 43.26 9.74 36 179839 2740 110406684
Renal cyst 43.17 9.74 93 179782 18079 110391345
Eosinophilic colitis 43.04 9.74 21 179854 622 110408802
Coronary artery stenosis 43.04 9.74 79 179796 13679 110395745
Diabetes mellitus 42.96 9.74 293 179582 99088 110310336
Injection site scab 42.95 9.74 21 179854 625 110408799
Sinus arrest 42.58 9.74 43 179832 4199 110405225
Exercise tolerance decreased 42.52 9.74 73 179802 11994 110397430
Blood lactic acid 42.51 9.74 19 179856 459 110408965
COVID-19 42.20 9.74 230 179645 244830 110164594
Wheezing 42.08 9.74 243 179632 254987 110154437
Sprue-like enteropathy 41.99 9.74 29 179846 1667 110407757
Atrioventricular block 41.98 9.74 88 179787 16789 110392635
Eructation 41.82 9.74 79 179796 13978 110395446
Injury 41.68 9.74 148 179727 177117 110232307
Loss of personal independence in daily activities 41.06 9.74 117 179758 149903 110259521
Retinitis 41.00 9.74 3 179872 32324 110377100
Aortic arteriosclerosis 40.97 9.74 68 179807 10870 110398554
Product dose omission issue 40.82 9.74 331 179544 321451 110087973
Ventricular extrasystoles 40.81 9.74 104 179771 22537 110386887
Nasopharyngitis 40.40 9.74 428 179447 393933 110015491
Malnutrition 39.86 9.74 116 179759 27163 110382261
Seroma 39.79 9.74 37 179838 3264 110406160
Foetal disorder 39.72 9.74 13 179862 128 110409296
Musculoskeletal pain 39.66 9.74 158 179717 182865 110226559
Ventricular hypertrophy 39.64 9.74 53 179822 6992 110402432
Back injury 39.22 9.74 14 179861 47385 110362039
Intentional product misuse 39.12 9.74 100 179775 132804 110276620
Coronary artery occlusion 38.95 9.74 82 179793 15690 110393734
Road traffic accident 38.90 9.74 72 179803 107326 110302098
Asthenia 38.52 9.74 1426 178449 687573 109721851
Shock 38.45 9.74 181 179694 53407 110356017
Hepatic function abnormal 38.44 9.74 263 179612 89032 110320392
Taste disorder 38.40 9.74 30 179845 65357 110344067
Dyspnoea exertional 38.19 9.74 295 179580 103765 110305659
Bone erosion 37.86 9.74 14 179861 46357 110363067
Ear infection 37.84 9.74 28 179847 62704 110346720
Arteriosclerosis 37.82 9.74 107 179768 24660 110384764
Pancreatic neoplasm 37.75 9.74 28 179847 1801 110407623
Gastritis erosive 37.66 9.74 69 179806 11931 110397493
Aortic valve stenosis 37.62 9.74 49 179826 6301 110403123
Ischaemic cardiomyopathy 37.24 9.74 55 179820 7956 110401468
Incorrect route of product administration 36.86 9.74 30 179845 64031 110345393
Sleep disorder due to a general medical condition 35.89 9.74 20 179855 52092 110357332
Coronary artery restenosis 35.83 9.74 23 179852 1169 110408255
N-terminal prohormone brain natriuretic peptide abnormal 35.80 9.74 15 179860 308 110409116
Blood sodium decreased 35.64 9.74 140 179735 38179 110371245
Product substitution issue 35.58 9.74 100 179775 22961 110386463
Diabetic retinopathy 35.54 9.74 36 179839 3528 110405896
Renal cell carcinoma 35.44 9.74 52 179823 7478 110401946
Haemoglobin decreased 35.41 9.74 585 179290 248142 110161282
Lacunar infarction 34.92 9.74 47 179828 6239 110403185
Dyslipidaemia 34.87 9.74 79 179796 15886 110393538
Left ventricular dysfunction 34.43 9.74 100 179775 23393 110386031
Therapy partial responder 34.17 9.74 9 179866 37052 110372372
Anuria 34.13 9.74 102 179773 24239 110385185
Chronic pigmented purpura 33.75 9.74 14 179861 280 110409144
Adrenal adenoma 33.42 9.74 24 179851 1468 110407956
Vascular resistance pulmonary decreased 33.31 9.74 10 179865 72 110409352
Venous pressure jugular increased 33.19 9.74 23 179852 1329 110408095
Fear 32.34 9.74 97 179778 23096 110386328
Prescribed underdose 32.24 9.74 35 179840 65139 110344285
Coeliac disease 32.09 9.74 15 179860 43172 110366252
Aspartate aminotransferase increased 31.86 9.74 399 179476 159537 110249887
Emotional distress 31.83 9.74 151 179724 44696 110364728
Sedation 31.70 9.74 40 179835 69643 110339781
Hypochromic anaemia 31.32 9.74 32 179843 3169 110406255
Carotid artery stenosis 31.29 9.74 55 179820 9208 110400216
Oral candidiasis 31.25 9.74 150 179725 44610 110364814
Joint stiffness 31.21 9.74 38 179837 67205 110342219
Colon cancer 31.18 9.74 77 179798 16366 110393058
Periarthritis calcarea 31.16 9.74 10 179865 92 110409332
Cell marker increased 30.54 9.74 17 179858 664 110408760
Bundle branch block right 30.47 9.74 64 179811 12227 110397197
Abortion spontaneous 30.35 9.74 9 179866 34273 110375151
Inguinal hernia 30.25 9.74 49 179826 7676 110401748
Idiopathic pulmonary fibrosis 30.25 9.74 39 179836 4965 110404459
Postoperative wound infection 30.11 9.74 74 179801 15679 110393745
Proteinuria 30.06 9.74 137 179738 39881 110369543
Left ventricular dilatation 29.87 9.74 22 179853 1400 110408024
Glycosylated haemoglobin increased 29.44 9.74 95 179780 23524 110385900
Blood alkaline phosphatase increased 29.40 9.74 207 179668 70728 110338696
Haematuria 29.18 9.74 233 179642 82772 110326652
Pulmonary fibrosis 29.10 9.74 78 179797 101964 110307460
Coronary artery bypass 28.84 9.74 42 179833 6000 110403424
Foot deformity 28.78 9.74 22 179853 48458 110360966
Altered state of consciousness 28.64 9.74 176 179699 57450 110351974
Status epilepticus 28.48 9.74 8 179867 31563 110377861
Faecaloma 28.47 9.74 70 179805 14838 110394586
Inflammation 28.21 9.74 191 179684 193047 110216377
Hypertensive heart disease 28.07 9.74 36 179839 4560 110404864
Haematocrit decreased 28.02 9.74 194 179681 65923 110343501
Chest injury 27.90 9.74 31 179844 3378 110406046
Blood triglycerides increased 27.82 9.74 94 179781 23832 110385592
Progressive bulbar palsy 27.46 9.74 9 179866 89 110409335
Left ventricular hypertrophy 27.24 9.74 64 179811 13180 110396244
Vertigo 26.90 9.74 237 179638 86633 110322791
Concomitant disease progression 26.45 9.74 31 179844 3579 110405845
Forced expiratory volume decreased 26.37 9.74 63 179812 13113 110396311
Nodal rhythm 26.10 9.74 30 179845 3393 110406031
Sciatica 26.07 9.74 71 179804 92328 110317096
Oxygen saturation increased 26.05 9.74 16 179859 752 110408672
Brain natriuretic peptide abnormal 26.01 9.74 17 179858 891 110408533
Product contamination 25.94 9.74 23 179852 1908 110407516
Coronary angioplasty 25.89 9.74 13 179862 410 110409014
Sinus node dysfunction 25.88 9.74 50 179825 8997 110400427
Exostosis 25.85 9.74 22 179853 45934 110363490
Low density lipoprotein increased 25.81 9.74 55 179820 10611 110398813
Orthostatic intolerance 25.81 9.74 24 179851 2117 110407307
Fear of disease 25.80 9.74 20 179855 1375 110408049
X-ray abnormal 25.72 9.74 15 179860 38102 110371322
Cough 25.65 9.74 955 178920 460686 109948738
Hyperuricaemia 25.42 9.74 66 179809 14465 110394959
Red blood cell sedimentation rate increased 25.36 9.74 56 179819 78246 110331178
Blood cholesterol increased 25.33 9.74 186 179689 184599 110224825
Device dislocation 25.17 9.74 10 179865 31694 110377730
Impaired work ability 25.16 9.74 6 179869 26413 110383011
Gait inability 25.15 9.74 125 179750 136251 110273173
Decreased appetite 25.15 9.74 979 178896 474867 109934557
Multiple drug therapy 25.04 9.74 46 179829 7968 110401456
Drug resistance 24.98 9.74 33 179842 56341 110353083
Injection site pain 24.92 9.74 178 179697 177744 110231680
Hepatitis E antibody positive 24.91 9.74 11 179864 258 110409166
Weight increased 24.89 9.74 507 179368 419137 109990287
Groin pain 24.89 9.74 68 179807 15360 110394064
Presyncope 24.73 9.74 150 179725 48737 110360687
Monoplegia 24.71 9.74 35 179840 4874 110404550
Gastric cancer 24.63 9.74 55 179820 10953 110398471
Therapeutic drug monitoring analysis incorrectly performed 24.58 9.74 15 179860 697 110408727
Left-to-right cardiac shunt 24.53 9.74 10 179865 191 110409233
Diastolic dysfunction 24.49 9.74 59 179816 12345 110397079
Nephrotic syndrome 24.38 9.74 63 179812 13768 110395656
Gastric ulcer haemorrhage 24.37 9.74 52 179823 10042 110399382
Obstructive airways disorder 24.24 9.74 143 179732 46006 110363418
Haemarthrosis 24.09 9.74 43 179832 7286 110402138
Wound dehiscence 24.00 9.74 45 179830 7917 110401507
Forced vital capacity decreased 23.59 9.74 22 179853 1948 110407476
Drug dependence 23.50 9.74 28 179847 49992 110359432
Hepatitis E virus test positive 23.48 9.74 11 179864 297 110409127
Erectile dysfunction 23.46 9.74 75 179800 18481 110390943
Atrial thrombosis 23.39 9.74 32 179843 4314 110405110
Blood aldosterone increased 23.36 9.74 10 179865 217 110409207
Carotid artery disease 23.17 9.74 23 179852 2200 110407224
Cytopenia 23.10 9.74 10 179865 30106 110379318
Renal injury 23.08 9.74 75 179800 18638 110390786
Haemorrhage subcutaneous 22.88 9.74 36 179839 5503 110403921
Ventricular hypokinesia 22.85 9.74 54 179821 11160 110398264
Prerenal failure 22.75 9.74 32 179843 4427 110404997
Basal ganglion degeneration 22.65 9.74 12 179863 424 110409000
Metabolic acidosis 22.57 9.74 255 179620 99489 110309935
Blood pressure abnormal 22.56 9.74 84 179791 22340 110387084
Distributive shock 22.51 9.74 37 179838 5867 110403557
Blood pressure systolic decreased 22.44 9.74 60 179815 13381 110396043
Orthopnoea 22.38 9.74 53 179822 10968 110398456
Finger deformity 22.36 9.74 13 179862 33079 110376345
Articular calcification 22.32 9.74 10 179865 243 110409181
Toxic skin eruption 22.03 9.74 96 179779 27419 110382005
Malignant melanoma 22.02 9.74 69 179806 16822 110392602
Adrenal cyst 21.95 9.74 10 179865 253 110409171
Ventricular tachycardia 21.94 9.74 148 179727 49861 110359563
Gastritis 21.84 9.74 156 179719 53543 110355881
Post streptococcal glomerulonephritis 21.71 9.74 8 179867 115 110409309
Lateropulsion 21.69 9.74 4 179871 0 110409424
Complex regional pain syndrome 21.66 9.74 23 179852 2382 110407042
Clostridium difficile infection 21.62 9.74 32 179843 52097 110357327
Iron deficiency anaemia 21.48 9.74 105 179770 31454 110377970
Peripheral arterial occlusive disease 21.48 9.74 47 179828 9233 110400191
Alanine aminotransferase increased 21.46 9.74 419 179456 183354 110226070
Aortic valve incompetence 21.43 9.74 52 179823 10929 110398495
Psychotic disorder 21.38 9.74 31 179844 50906 110358518
Intentional overdose 21.37 9.74 127 179748 132374 110277050
Angiotensin converting enzyme inhibitor foetopathy 21.36 9.74 6 179869 33 110409391
Adrenomegaly 21.32 9.74 12 179863 479 110408945
Subdural haematoma 21.15 9.74 116 179759 36338 110373086
Renin decreased 21.10 9.74 8 179867 125 110409299
Brain contusion 21.09 9.74 19 179856 1609 110407815
Azotaemia 21.03 9.74 49 179826 10036 110399388
Anhedonia 21.02 9.74 64 179811 15364 110394060
Intentional self-injury 20.95 9.74 18 179857 37411 110372013
Dementia Alzheimer's type 20.94 9.74 15 179860 914 110408510
Brain stem stroke 20.87 9.74 14 179861 767 110408657
Electrocardiogram QRS complex abnormal 20.85 9.74 14 179861 768 110408656
Peripheral swelling 20.85 9.74 499 179376 403535 110005889
Rhythm idioventricular 20.80 9.74 14 179861 771 110408653
Osteogenesis imperfecta 20.74 9.74 14 179861 775 110408649
Confusional state 20.71 9.74 592 179283 468088 109941336
Basilar artery occlusion 20.69 9.74 10 179865 290 110409134
Graft versus host disease 20.62 9.74 3 179872 18803 110390621
Epistaxis 20.57 9.74 312 179563 130060 110279364
Circulatory collapse 20.55 9.74 130 179745 42863 110366561
Paraesthesia 20.54 9.74 321 179554 276200 110133224
Conduction disorder 20.54 9.74 29 179846 4026 110405398
Electrocardiogram ST segment depression 20.52 9.74 34 179841 5427 110403997
Peripheral vascular disorder 20.50 9.74 44 179831 8532 110400892
Product monitoring error 20.42 9.74 45 179830 8882 110400542
Suicidal ideation 20.40 9.74 81 179794 93856 110315568
Duodenal ulcer 20.39 9.74 74 179801 19440 110389984
Pericardial haemorrhage 20.31 9.74 33 179842 5184 110404240
International normalised ratio increased 20.17 9.74 223 179652 86549 110322875
Uterine enlargement 20.15 9.74 15 179860 970 110408454
Hypertensive emergency 20.07 9.74 26 179849 3325 110406099
Haemodialysis 20.06 9.74 69 179806 17650 110391774
Cytokine release syndrome 19.85 9.74 54 179821 70252 110339172
Peak expiratory flow rate decreased 19.80 9.74 13 179862 687 110408737
Faeces discoloured 19.68 9.74 108 179767 33840 110375584
Haematotoxicity 19.67 9.74 5 179870 21077 110388347
Speech disorder 19.59 9.74 169 179706 61400 110348024
Hypocalvaria 19.54 9.74 6 179869 47 110409377
Pericardial effusion 19.24 9.74 159 179716 57058 110352366
Haemophagocytic lymphohistiocytosis 19.15 9.74 14 179861 31545 110377879
Platelet aggregation abnormal 19.11 9.74 6 179869 51 110409373
Nephrogenic systemic fibrosis 19.10 9.74 33 179842 5450 110403974
Immunodeficiency 19.05 9.74 21 179854 38817 110370607
Hepatic cytolysis 18.98 9.74 38 179837 55015 110354409
Ophthalmic vein thrombosis 18.91 9.74 9 179866 252 110409172
Protein urine present 18.91 9.74 51 179824 11433 110397991
Device issue 18.86 9.74 17 179858 34518 110374906
Shock haemorrhagic 18.80 9.74 91 179784 27156 110382268
Hyperlipidaemia 18.78 9.74 111 179764 35737 110373687
Rectal prolapse 18.77 9.74 22 179853 2541 110406883
Haemangioma 18.70 9.74 23 179852 2793 110406631
Hemiplegia 18.63 9.74 80 179795 22702 110386722
Fatigue 18.62 9.74 1714 178161 1214244 109195180
Goitre 18.62 9.74 35 179840 6169 110403255
Haemorrhagic stroke 18.60 9.74 57 179818 13732 110395692
Cold sweat 18.51 9.74 78 179797 21953 110387471
Inappropriate antidiuretic hormone secretion 18.50 9.74 106 179769 33745 110375679
Retrograde amnesia 18.42 9.74 13 179862 774 110408650
Diverticulum intestinal haemorrhagic 18.37 9.74 30 179845 4733 110404691
Pulmonary arterial pressure abnormal 18.36 9.74 14 179861 939 110408485
Hypogammaglobulinaemia 18.27 9.74 5 179870 20071 110389353
Cardiac vein perforation 18.20 9.74 5 179870 25 110409399
Labelled drug-drug interaction medication error 18.20 9.74 95 179780 29207 110380217
Lichen planus 18.19 9.74 25 179850 3385 110406039
Heart rate increased 18.19 9.74 332 179543 143502 110265922
Atrial flutter 18.18 9.74 83 179792 24179 110385245
Breast cancer 18.08 9.74 116 179759 38426 110370998
Pneumothorax traumatic 18.04 9.74 9 179866 280 110409144
Acute coronary syndrome 18.02 9.74 80 179795 23032 110386392
Extrasystoles 17.99 9.74 41 179834 8277 110401147
Erythema multiforme 17.96 9.74 75 179800 21022 110388402
Lupus-like syndrome 17.95 9.74 24 179851 40768 110368656
Ejection fraction decreased 17.94 9.74 121 179754 40759 110368665
Lung diffusion disorder 17.89 9.74 9 179866 285 110409139
Nephrogenic anaemia 17.88 9.74 29 179846 4548 110404876
Skin reaction 17.87 9.74 75 179800 21069 110388355
Malabsorption 17.76 9.74 35 179840 6390 110403034
Product dose omission in error 17.73 9.74 8 179867 23504 110385920
Product odour abnormal 17.66 9.74 17 179858 1566 110407858
Onychomycosis 17.65 9.74 22 179853 38509 110370915
Transplant rejection 17.55 9.74 9 179866 24558 110384866
Cerebral arteriosclerosis 17.49 9.74 13 179862 839 110408585
Drug tolerance 17.39 9.74 3 179872 16582 110392842
Pruritus 17.36 9.74 771 179104 580789 109828635
Hypertrophic osteoarthropathy 17.35 9.74 7 179868 130 110409294
Nervousness 17.35 9.74 111 179764 36740 110372684
Abdominal tenderness 17.28 9.74 52 179823 12405 110397019
Tissue infiltration 17.24 9.74 14 179861 1029 110408395
Normal newborn 17.23 9.74 7 179868 21889 110387535
Neoplasm progression 17.21 9.74 51 179824 64544 110344880
Lipase increased 17.19 9.74 68 179807 18604 110390820
Neutrophil function disorder 17.16 9.74 5 179870 32 110409392
Multiple injuries 17.07 9.74 25 179850 3589 110405835
Pleural disorder 17.06 9.74 14 179861 1045 110408379
Motor neurone disease 17.04 9.74 12 179863 712 110408712
Cardiac pacemaker insertion 17.02 9.74 34 179841 6267 110403157
Microalbuminuria 17.02 9.74 15 179860 1234 110408190
Pigmentation disorder 16.89 9.74 37 179838 7274 110402150
Knee arthroplasty 16.79 9.74 52 179823 64896 110344528
Cytomegalovirus infection 16.77 9.74 40 179835 54404 110355020
Sleep apnoea syndrome 16.74 9.74 118 179757 40329 110369095
Upper gastrointestinal haemorrhage 16.73 9.74 139 179736 49957 110359467
Anaphylactic reaction 16.67 9.74 113 179762 114187 110295237
Laryngitis 16.66 9.74 27 179848 42384 110367040
Therapy interrupted 16.66 9.74 35 179840 49787 110359637
Subacute hepatic failure 16.65 9.74 8 179867 229 110409195
Device leakage 16.61 9.74 3 179872 16045 110393379
Antinuclear antibody negative 16.61 9.74 7 179868 146 110409278
Pollakiuria 16.61 9.74 126 179749 44069 110365355
Anaesthesia 16.56 9.74 11 179864 593 110408831
Face oedema 16.49 9.74 102 179773 33367 110376057
Kyphosis 16.45 9.74 23 179852 3164 110406260
Periodontitis 16.41 9.74 30 179845 5178 110404246
Painful respiration 16.38 9.74 25 179850 3722 110405702
Hypercholesterolaemia 16.33 9.74 84 179791 90753 110318671
Merycism 16.30 9.74 9 179866 346 110409078
Blood thyroid stimulating hormone abnormal 16.28 9.74 14 179861 1115 110408309
Disease recurrence 16.19 9.74 48 179827 60736 110348688
Infarction 16.16 9.74 30 179845 5239 110404185
Hypovolaemia 16.13 9.74 74 179801 21600 110387824
Hepatic calcification 16.06 9.74 9 179866 356 110409068
Pyometra 16.05 9.74 6 179869 90 110409334
Cardiogenic shock 16.01 9.74 153 179722 57185 110352239
Acute phosphate nephropathy 15.98 9.74 5 179870 42 110409382
Sudden cardiac death 15.93 9.74 31 179844 5606 110403818
Costal cartilage fracture 15.92 9.74 8 179867 253 110409171
Blood pressure fluctuation 15.91 9.74 189 179686 74635 110334789
Peptic ulcer 15.87 9.74 37 179838 7582 110401842
Visual acuity reduced 15.82 9.74 98 179777 32075 110377349
Osteochondrosis 15.79 9.74 20 179855 2501 110406923
Lipid metabolism disorder 15.76 9.74 11 179864 643 110408781
Hypoaesthesia 15.68 9.74 390 179485 313833 110095591
Premature delivery 15.65 9.74 16 179859 30616 110378808
Actinic keratosis 15.65 9.74 35 179840 6978 110402446
Schizophrenia 15.58 9.74 8 179867 21818 110387606
Drug use disorder 15.54 9.74 5 179870 18069 110391355
Blood chloride decreased 15.53 9.74 41 179834 9074 110400350
Functional residual capacity increased 15.53 9.74 6 179869 99 110409325
Hypoventilation 15.49 9.74 38 179837 8043 110401381
Venoocclusive liver disease 15.41 9.74 3 179872 15204 110394220
Amyotrophic lateral sclerosis 15.40 9.74 18 179857 2073 110407351
Tessellated fundus 15.39 9.74 5 179870 48 110409376
Gastroenteritis 15.36 9.74 112 179763 38688 110370736
Palpitations 15.34 9.74 353 179522 158859 110250565
Arteriosclerosis coronary artery 15.30 9.74 81 179794 25037 110384387
Post-anoxic myoclonus 15.30 9.74 5 179870 49 110409375
Acral lentiginous melanoma 15.30 9.74 5 179870 49 110409375
Chest wall haematoma 15.29 9.74 10 179865 525 110408899
Blood aldosterone decreased 15.28 9.74 4 179871 16 110409408
Sinus bradycardia 15.26 9.74 91 179784 29392 110380032
Disability 15.20 9.74 16 179859 30207 110379217
Hyperinsulinaemia 15.20 9.74 8 179867 279 110409145
Gouty arthritis 15.18 9.74 16 179859 1643 110407781
Lower respiratory tract inflammation 15.15 9.74 7 179868 183 110409241
Cytomegalovirus viraemia 15.12 9.74 5 179870 17759 110391665
Acquired haemophilia 15.12 9.74 20 179855 2611 110406813
Acquired C1 inhibitor deficiency 15.09 9.74 4 179871 17 110409407
Gastritis haemorrhagic 15.06 9.74 22 179853 3151 110406273
Polyuria 15.06 9.74 63 179812 17675 110391749
Pyonephrosis 15.05 9.74 7 179868 186 110409238
Underdose 14.97 9.74 53 179822 63501 110345923
Fractured coccyx 14.97 9.74 14 179861 1244 110408180
Ear pain 14.94 9.74 41 179834 53185 110356239
Renal neoplasm 14.94 9.74 19 179856 2387 110407037
Urine output decreased 14.89 9.74 68 179807 19808 110389616
Immune reconstitution inflammatory syndrome 14.85 9.74 4 179871 16222 110393202
Glomerulosclerosis 14.79 9.74 14 179861 1263 110408161
Pulmonary hypertension 14.76 9.74 146 179729 55074 110354350
Food allergy 14.71 9.74 7 179868 19941 110389483
Neurotoxicity 14.66 9.74 29 179846 42178 110367246
Thalamus haemorrhage 14.62 9.74 17 179858 1947 110407477
Product complaint 14.61 9.74 53 179822 13919 110395505
Superficial spreading melanoma stage I 14.46 9.74 5 179870 59 110409365
Sudden death 14.40 9.74 78 179797 24317 110385107
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.36 9.74 29 179846 5388 110404036
Renal embolism 14.30 9.74 7 179868 209 110409215
Hypochloraemia 14.24 9.74 23 179852 3595 110405829
Periodontal disease 14.22 9.74 17 179858 2005 110407419
Miscarriage of partner 14.19 9.74 3 179872 3 110409421
Stenosis 14.15 9.74 22 179853 3329 110406095
Myoglobin blood increased 14.13 9.74 25 179850 4207 110405217
Dysuria 14.09 9.74 155 179720 60076 110349348
Bladder transitional cell carcinoma 14.06 9.74 20 179855 2796 110406628
Respiratory rate increased 14.01 9.74 79 179796 25004 110384420
No adverse event 14.01 9.74 67 179808 73772 110335652
Progressive multifocal leukoencephalopathy 13.97 9.74 12 179863 24944 110384480
Transitional cell cancer of the renal pelvis and ureter 13.96 9.74 5 179870 66 110409358
Cardiac myxoma 13.91 9.74 7 179868 222 110409202
Brain natriuretic peptide increased 13.89 9.74 45 179830 11164 110398260
Large intestine polyp 13.87 9.74 55 179820 15062 110394362
Cholelithiasis 13.84 9.74 161 179714 63261 110346163
Hyponatraemic syndrome 13.82 9.74 11 179864 786 110408638
Cerebrovascular disorder 13.81 9.74 23 179852 3688 110405736
Aortic dissection 13.79 9.74 27 179848 4906 110404518
Blood loss anaemia 13.76 9.74 62 179813 17963 110391461
Neutropenic sepsis 13.62 9.74 18 179857 30728 110378696
Gout 13.60 9.74 104 179771 36462 110372962
Laryngeal pain 13.54 9.74 30 179845 5945 110403479
Gastrointestinal stromal tumour 13.50 9.74 17 179858 2114 110407310
Brain stem infarction 13.48 9.74 17 179858 2117 110407307
Basal ganglia haemorrhage 13.48 9.74 16 179859 1872 110407552
Vascular device infection 13.45 9.74 5 179870 16507 110392917
Vomiting 13.44 9.74 1287 178588 909388 109500036
Gait disturbance 13.43 9.74 567 179308 277641 110131783
Vertebral artery occlusion 13.42 9.74 9 179866 493 110408931
Chondrocalcinosis pyrophosphate 13.42 9.74 15 179860 1646 110407778
Diabetic nephropathy 13.40 9.74 22 179853 3486 110405938
Renin increased 13.38 9.74 8 179867 358 110409066
Aortic valve sclerosis 13.38 9.74 16 179859 1887 110407537
Aneurysm 13.24 9.74 25 179850 4421 110405003
Blood phosphorus increased 13.23 9.74 5 179870 16335 110393089
Gingival ulceration 13.15 9.74 13 179862 1237 110408187
Pancreatitis acute 13.15 9.74 153 179722 60121 110349303
Urinary retention 13.09 9.74 172 179703 69511 110339913
Activated partial thromboplastin time shortened 13.04 9.74 12 179863 1045 110408379
Gastric ulcer helicobacter 12.96 9.74 4 179871 32 110409392
Carcinogenicity 12.95 9.74 6 179869 158 110409266
Angioplasty 12.93 9.74 16 179859 1955 110407469
Left atrial enlargement 12.91 9.74 15 179860 1716 110407708
Metastatic bronchial carcinoma 12.89 9.74 8 179867 383 110409041
Eosinophil count increased 12.89 9.74 68 179807 20990 110388434
Manufacturing materials contamination 12.85 9.74 4 179871 33 110409391
Foetal death 12.84 9.74 5 179870 16040 110393384
Ankle fracture 12.82 9.74 65 179810 19754 110389670
Lactose intolerance 12.82 9.74 19 179856 2757 110406667
Stent placement 12.80 9.74 33 179842 7201 110402223
Cardiac fibrillation 12.80 9.74 12 179863 1070 110408354
Metamyelocyte count increased 12.79 9.74 10 179865 696 110408728
Inflammatory marker increased 12.76 9.74 52 179823 14417 110395007
Putamen haemorrhage 12.75 9.74 9 179866 536 110408888
Hypercreatininaemia 12.65 9.74 13 179862 1296 110408128
Arrhythmogenic right ventricular dysplasia 12.64 9.74 5 179870 88 110409336
Frustration tolerance decreased 12.63 9.74 37 179838 8694 110400730
Skin texture abnormal 12.61 9.74 9 179866 545 110408879
Eosinophilia 12.61 9.74 147 179728 57789 110351635
Mucosal inflammation 12.59 9.74 98 179777 96043 110313381
Surfactant protein increased 12.54 9.74 4 179871 36 110409388
Intermittent claudication 12.53 9.74 22 179853 3679 110405745
Malignant neoplasm progression 12.51 9.74 204 179671 174363 110235061
Hyperthyroidism 12.48 9.74 86 179789 29175 110380249
Respiratory syncytial virus infection 12.47 9.74 4 179871 14480 110394944
Cutaneous lymphoma 12.44 9.74 7 179868 279 110409145
Nephrocalcinosis 12.34 9.74 15 179860 1799 110407625
Jaundice 12.32 9.74 149 179726 59087 110350337
Withdrawal hypertension 12.32 9.74 8 179867 415 110409009
Brain stem haemorrhage 12.26 9.74 15 179860 1811 110407613
Cutaneous vasculitis 12.24 9.74 47 179828 12682 110396742
Chronic coronary syndrome 12.20 9.74 7 179868 290 110409134
Occult blood positive 12.19 9.74 33 179842 7412 110402012
Paralysis 12.16 9.74 54 179821 15546 110393878
Perihepatic discomfort 12.13 9.74 3 179872 9 110409415
Abdominal distension 12.09 9.74 206 179669 174897 110234527
Carcinoid tumour 12.04 9.74 9 179866 586 110408838
Tonic clonic movements 11.94 9.74 19 179856 2933 110406491
Body height decreased 11.84 9.74 41 179834 10522 110398902
Sense of oppression 11.82 9.74 14 179861 1634 110407790
Laryngeal oedema 11.82 9.74 39 179836 9768 110399656
Respiration abnormal 11.82 9.74 39 179836 9770 110399654
Osteoporosis 11.81 9.74 88 179787 87064 110322360
Gravitational oedema 11.80 9.74 15 179860 1883 110407541
Cardiac valve sclerosis 11.79 9.74 5 179870 106 110409318
Intestinal polyp 11.76 9.74 17 179858 2412 110407012
Low density lipoprotein decreased 11.76 9.74 13 179862 1409 110408015
Lung diffusion test decreased 11.71 9.74 14 179861 1651 110407773
Erythema 11.69 9.74 583 179292 290864 110118560
Granuloma 11.67 9.74 38 179837 9452 110399972
Atrioventricular block first degree 11.67 9.74 50 179825 14175 110395249
Affect lability 11.66 9.74 8 179867 18629 110390795
Aggression 11.66 9.74 53 179822 59157 110350267
Bacteraemia 11.64 9.74 33 179842 42357 110367067
Laboratory test abnormal 11.60 9.74 35 179840 44044 110365380
Percutaneous coronary intervention 11.60 9.74 8 179867 459 110408965
Infusion site pain 11.55 9.74 7 179868 17412 110392012
Diverticulum 11.55 9.74 53 179822 15473 110393951
Ulcer 11.52 9.74 34 179841 43082 110366342
Blood uric acid increased 11.49 9.74 67 179808 21462 110387962
Procalcitonin decreased 11.49 9.74 5 179870 113 110409311
Depressed level of consciousness 11.46 9.74 251 179624 112027 110297397
Incision site oedema 11.46 9.74 3 179872 12 110409412
Hepatobiliary cancer 11.46 9.74 3 179872 12 110409412
Oesophageal achalasia 11.46 9.74 11 179864 1010 110408414
Chronic obstructive pulmonary disease 11.46 9.74 245 179630 108913 110300511
Adenocarcinoma 11.45 9.74 23 179852 4257 110405167
Hypersensitivity pneumonitis 11.44 9.74 26 179849 5239 110404185
Cutaneous listeriosis 11.44 9.74 4 179871 49 110409375
Bradyarrhythmia 11.43 9.74 25 179850 4909 110404515
Pharyngeal oedema 11.43 9.74 55 179820 16373 110393051
Photosensitivity reaction 11.39 9.74 76 179799 25513 110383911
Aspergillus infection 11.34 9.74 15 179860 25601 110383823
Prostate cancer 11.29 9.74 102 179773 37539 110371885
Phimosis 11.28 9.74 10 179865 829 110408595
Non-cardiogenic pulmonary oedema 11.28 9.74 15 179860 1969 110407455
Contusion 11.27 9.74 291 179584 233070 110176354
Hepatitis 11.24 9.74 93 179782 89961 110319463
Infective pulmonary exacerbation of cystic fibrosis 11.18 9.74 5 179870 14766 110394658
Immature granulocyte count increased 11.10 9.74 10 179865 847 110408577
Blood phosphorus abnormal 11.10 9.74 7 179868 345 110409079
Chronic leukaemia 11.09 9.74 3 179872 14 110409410
Blood glucose abnormal 11.06 9.74 46 179829 12870 110396554
Skin induration 11.03 9.74 23 179852 4372 110405052
Impaired quality of life 10.98 9.74 20 179855 29997 110379427
Renal disorder 10.97 9.74 126 179749 49353 110360071
Hypertrophic cardiomyopathy 10.97 9.74 19 179856 3144 110406280
Amoebic colitis 10.96 9.74 5 179870 127 110409297
Dry eye 10.95 9.74 50 179825 55743 110353681
Congestive cardiomyopathy 10.92 9.74 49 179826 14170 110395254
Retinopathy 10.91 9.74 23 179852 4406 110405018
Spinal osteoarthritis 10.90 9.74 63 179812 20120 110389304
Bezold-Jarisch reflex 10.89 9.74 4 179871 57 110409367
Dysgeusia 10.85 9.74 167 179708 69818 110339606
Total lung capacity increased 10.84 9.74 25 179850 5087 110404337
Body mass index increased 10.84 9.74 16 179859 2314 110407110
Liver iron concentration abnormal 10.82 9.74 4 179871 58 110409366
Papillary renal cell carcinoma 10.80 9.74 7 179868 362 110409062
Peripheral coldness 10.76 9.74 59 179816 18481 110390943
Duodenal polyp 10.75 9.74 8 179867 517 110408907
Gastrointestinal submucosal tumour 10.74 9.74 5 179870 133 110409291
Heliotrope rash 10.69 9.74 6 179869 238 110409186
Bone marrow failure 10.68 9.74 53 179822 57795 110351629
Blood pressure diastolic decreased 10.64 9.74 97 179778 35788 110373636
Gastric mucosa erythema 10.63 9.74 8 179867 526 110408898
BK virus infection 10.63 9.74 4 179871 13102 110396322
Injection site swelling 10.62 9.74 58 179817 61732 110347692
Blood parathyroid hormone decreased 10.60 9.74 4 179871 13085 110396339
Lipoedema 10.58 9.74 6 179869 243 110409181
Hepatic cancer 10.57 9.74 41 179834 11115 110398309
Therapeutic response shortened 10.56 9.74 20 179855 29563 110379861
Thyroxine decreased 10.49 9.74 10 179865 910 110408514
Vascular graft 10.47 9.74 15 179860 2110 110407314
Mood swings 10.47 9.74 13 179862 22799 110386625
Immobilisation bandage 10.46 9.74 3 179872 18 110409406
Pseudomonas peritonitis 10.46 9.74 3 179872 18 110409406
Blood creatine phosphokinase MB 10.46 9.74 3 179872 18 110409406
Diabetic neuropathy 10.46 9.74 30 179845 6969 110402455
Cholecystitis 10.41 9.74 75 179800 25807 110383617
Renal tubular necrosis 10.41 9.74 85 179790 30390 110379034
Potentiating drug interaction 10.39 9.74 42 179833 11601 110397823
Pulmonary congestion 10.38 9.74 86 179789 30880 110378544
Fracture pain 10.38 9.74 11 179864 1137 110408287
Computerised tomogram abnormal 10.35 9.74 21 179854 3915 110405509
Aortic aneurysm rupture 10.22 9.74 12 179863 1388 110408036
Oesophageal food impaction 10.21 9.74 8 179867 559 110408865
Iron binding capacity total decreased 10.21 9.74 8 179867 559 110408865
Laryngeal haemorrhage 10.19 9.74 4 179871 69 110409355
Peritoneal haematoma 10.17 9.74 6 179869 262 110409162
Nodal arrhythmia 10.16 9.74 15 179860 2169 110407255
Meniere's disease 10.13 9.74 5 179870 152 110409272
Heart rate decreased 10.10 9.74 190 179685 82566 110326858
Hepatotoxicity 10.10 9.74 61 179814 63339 110346085
Pelvic floor repair 10.07 9.74 3 179872 21 110409403
Cytomegalovirus infection reactivation 10.04 9.74 9 179866 18324 110391100
Nephropathy 10.04 9.74 46 179829 13421 110396003
Histiocytic necrotising lymphadenitis 10.03 9.74 4 179871 72 110409352
Glucose tolerance impaired 10.02 9.74 37 179838 9800 110399624
Choroidal detachment 9.98 9.74 9 179866 763 110408661
Upper respiratory tract inflammation 9.96 9.74 22 179853 4349 110405075
Hypertransaminasaemia 9.95 9.74 15 179860 24240 110385184
Tongue haemorrhage 9.94 9.74 11 179864 1194 110408230
pH body fluid increased 9.93 9.74 4 179871 74 110409350
Primary hyperaldosteronism 9.93 9.74 6 179869 274 110409150
Haematemesis 9.92 9.74 143 179732 58965 110350459
Chronic gastritis 9.90 9.74 25 179850 5386 110404038
Monoclonal gammopathy 9.88 9.74 11 179864 1201 110408223
Haemorrhoids 9.87 9.74 95 179780 35577 110373847
Lip oedema 9.86 9.74 31 179844 7569 110401855
Fabry's disease 9.83 9.74 3 179872 23 110409401
Neutrophil count decreased 9.80 9.74 138 179737 120803 110288621
Bacterial infection 9.80 9.74 40 179835 45996 110363428
Cerebral artery occlusion 9.79 9.74 14 179861 1966 110407458
Breast cancer metastatic 9.78 9.74 3 179872 11178 110398246
Pancreatic carcinoma 9.78 9.74 49 179826 14823 110394601

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Renal failure 44.54 32.84 20 340 249 113344

Pharmacologic Action:

SourceCodeDescription
ATC C09CA03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
Angiotensin II receptor blockers (ARBs), plain
ATC C09DA03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and diuretics
ATC C09DB01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB08 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C10BX10 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000070 Angiotensin 2 Receptor Antagonists
FDA EPC N0000175561 Angiotensin 2 Receptor Blocker
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D047228 Angiotensin II Type 1 Receptor Blockers
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:61016 angiotensin receptor antagonist
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

C09CA Angiotensin II receptor blockers (ARBs), plain 9 drugs
azilsartan medoxomilcandesartan cilexetileprosartanfimasartanirbesartanlosartanolmesartan medoxomiltasosartantelmisartan
C09DA Angiotensin II receptor blockers (ARBs) and diuretics 8 drugs
azilsartan medoxomilcandesartan cilexetileprosartanfimasartanirbesartanlosartanolmesartan medoxomiltelmisartan
C09DB Angiotensin II receptor blockers (ARBs) and calcium channel blockers 8 drugs
amlodipinecandesartan cilexetilfimasartanirbesartanlercanidipinelosartanolmesartan medoxomiltelmisartan
C09DX Angiotensin II receptor blockers (ARBs), other combinations 10 drugs
aliskirenamlodipinecandesartan cilexetilhydrochlorothiazideindapamideirbesartannebivolololmesartan medoxomilsacubitriltelmisartan
C10BX Lipid modifying agents in combination with other drugs 14 drugs
acetylsalicylic acidamlodipineatorvastatincandesartan cilexetilfimasartanindapamidelisinoprilnebivololperindoprilpravastatinramiprilrosuvastatin show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Left ventricular cardiac dysfunction indication 429589006
Atrial fibrillation off-label use 49436004 DOID:0060224
Diabetic renal disease off-label use 127013003
Diastolic heart failure off-label use 418304008 DOID:9775
Nondiabetic Proteinuric Nephropathy off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Obstruction of bile duct contraindication 30144000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Azotemia contraindication 445009001
Severe Aortic Valve Stenosis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.8 acidic
pKa2 4.44 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
24MG;26MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 9388134 Nov. 8, 2026 TREATMENT OF HEART FAILURE
49MG;51MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 9388134 Nov. 8, 2026 TREATMENT OF HEART FAILURE
97MG;103MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 9388134 Nov. 8, 2026 TREATMENT OF HEART FAILURE
15MG;16MG ENTRESTO SPRINKLE NOVARTIS N218591 April 12, 2024 RX CAPSULE, PELLETS ORAL 9388134 Nov. 8, 2026 TREATMENT OF HEART FAILURE
6MG;6MG ENTRESTO SPRINKLE NOVARTIS N218591 April 12, 2024 RX CAPSULE, PELLETS ORAL 9388134 Nov. 8, 2026 TREATMENT OF HEART FAILURE
EQ 5MG BASE;80MG BYVALSON ABBVIE N206302 June 3, 2016 DISCN TABLET ORAL 7838552 Oct. 4, 2027 METHOD OF TREATING HYPERTENSION
24MG;26MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 11135192 Aug. 22, 2033 TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
24MG;26MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 9517226 Aug. 22, 2033 TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
24MG;26MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 9937143 Aug. 22, 2033 TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
49MG;51MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 11135192 Aug. 22, 2033 TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
49MG;51MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 9517226 Aug. 22, 2033 TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
49MG;51MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 9937143 Aug. 22, 2033 TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
97MG;103MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 11135192 Aug. 22, 2033 TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
97MG;103MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 9517226 Aug. 22, 2033 TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
97MG;103MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 9937143 Aug. 22, 2033 TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION
24MG;26MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 11058667 May 9, 2036 TREATING CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION IN PATIENTS NOT TAKING AN ACE INHIBITOR OR AN ARB OR PREVIOUSLY TAKING LOW DOSES OF THESE AGENTS, BY TITRATING UP FROM HALF THE USUALLY RECOMMENDED STARTING DOSE
49MG;51MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 11058667 May 9, 2036 TREATING CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION IN PATIENTS NOT TAKING AN ACE INHIBITOR OR AN ARB OR PREVIOUSLY TAKING LOW DOSES OF THESE AGENTS, BY TITRATING UP FROM HALF THE USUALLY RECOMMENDED STARTING DOSE
97MG;103MG ENTRESTO NOVARTIS PHARMS CORP N207620 July 7, 2015 RX TABLET ORAL 11058667 May 9, 2036 TREATING CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION IN PATIENTS NOT TAKING AN ACE INHIBITOR OR AN ARB OR PREVIOUSLY TAKING LOW DOSES OF THESE AGENTS, BY TITRATING UP FROM HALF THE USUALLY RECOMMENDED STARTING DOSE
15MG;16MG ENTRESTO SPRINKLE NOVARTIS N218591 April 12, 2024 RX CAPSULE, PELLETS ORAL 10722471 Feb. 2, 2037 TREATMENT OF HEART FAILURE WITH ORAL PELLETS
6MG;6MG ENTRESTO SPRINKLE NOVARTIS N218591 April 12, 2024 RX CAPSULE, PELLETS ORAL 10722471 Feb. 2, 2037 TREATMENT OF HEART FAILURE WITH ORAL PELLETS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Type-1 angiotensin II receptor GPCR ANTAGONIST Ki 5.33 CHEMBL CHEMBL
Platelet glycoprotein VI Membrane receptor Kd 4 CHEMBL
Type-1B angiotensin II receptor GPCR IC50 8.72 CHEMBL
Type-1A angiotensin II receptor GPCR IC50 8.47 CHEMBL
Angiotensin II receptor (AT-1) type-1 GPCR IC50 8.57 CHEMBL

External reference:

IDSource
D00400 KEGG_DRUG
4020986 VANDF
C0216784 UMLSCUI
CHEBI:9927 CHEBI
U35 PDB_CHEM_ID
CHEMBL1069 ChEMBL_ID
D000068756 MESH_DESCRIPTOR_UI
DB00177 DRUGBANK_ID
3937 IUPHAR_LIGAND_ID
7016 INN_ID
80M03YXJ7I UNII
60846 PUBCHEM_CID
216652 RXNORM
53010 MMSL
5663 MMSL
8844 MMSL
d04113 MMSL
006279 NDDF
108581009 SNOMEDCT_US
386876001 SNOMEDCT_US
80M03YXJ7I INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0314 TABLET, FILM COATED 80 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0315 TABLET, FILM COATED 160 mg ORAL NDA 31 sections
Diovan HUMAN PRESCRIPTION DRUG LABEL 1 0078-0358 TABLET 80 mg ORAL NDA 32 sections
Diovan HUMAN PRESCRIPTION DRUG LABEL 1 0078-0359 TABLET 160 mg ORAL NDA 32 sections
Diovan HUMAN PRESCRIPTION DRUG LABEL 1 0078-0360 TABLET 320 mg ORAL NDA 32 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0383 TABLET, FILM COATED 160 mg ORAL NDA 31 sections
Diovan HUMAN PRESCRIPTION DRUG LABEL 1 0078-0423 TABLET 40 mg ORAL NDA 32 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0471 TABLET, FILM COATED 320 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0472 TABLET, FILM COATED 320 mg ORAL NDA 31 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0488 TABLET, FILM COATED 160 mg ORAL NDA 31 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0489 TABLET, FILM COATED 160 mg ORAL NDA 31 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0490 TABLET, FILM COATED 320 mg ORAL NDA 31 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0491 TABLET, FILM COATED 320 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0559 TABLET, FILM COATED 160 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0560 TABLET, FILM COATED 160 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0561 TABLET, FILM COATED 160 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0562 TABLET, FILM COATED 160 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0563 TABLET, FILM COATED 320 mg ORAL NDA 31 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-0659 TABLET, FILM COATED 26 mg ORAL NDA 35 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-0659 TABLET, FILM COATED 26 mg ORAL NDA 35 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-0696 TABLET, FILM COATED 103 mg ORAL NDA 35 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-0696 TABLET, FILM COATED 103 mg ORAL NDA 35 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-0777 TABLET, FILM COATED 51 mg ORAL NDA 35 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-0777 TABLET, FILM COATED 51 mg ORAL NDA 35 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-1231 PELLET 6 mg ORAL NDA 35 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-1231 PELLET 6 mg ORAL NDA 35 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-1238 PELLET 16 mg ORAL NDA 35 sections
ENTRESTO HUMAN PRESCRIPTION DRUG LABEL 2 0078-1238 PELLET 16 mg ORAL NDA 35 sections
Diovan HUMAN PRESCRIPTION DRUG LABEL 1 0078-1245 TABLET 80 mg ORAL NDA 32 sections
Diovan HUMAN PRESCRIPTION DRUG LABEL 1 0078-1252 TABLET 160 mg ORAL NDA 32 sections