zofenopril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 2866 81872-10-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zofenopril
  • zofenopril calcium
  • SQ-26991
  • SQ. 26,991
  • zofenopril potassium
  • Molecular weight: 429.55
  • Formula: C22H23NO4S2
  • CLOGP: 4.68
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 74.68
  • ALOGS: -5.14
  • ROTB: 8

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA15 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA15 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
CHEBI has role CHEBI:77307 cardioprotective agent
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:35620 vasodilator agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.94 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 9.40 CHEMBL SCIENTIFIC LITERATURE
Angiotensin-converting enzyme Enzyme Ki 9.40 CHEMBL
Angiotensin-converting enzyme Enzyme IC50 8.10 CHEMBL

External reference:

IDSource
C0078836 UMLSCUI
D03767 KEGG_DRUG
290ZY759PI UNII
5535 INN_ID
75176-37-3 SECONDARY_CAS_RN
703662000 SNOMEDCT_US
39990 RXNORM
703340007 SNOMEDCT_US
008183 NDDF
CHEMBL16332 ChEMBL_ID
CHEMBL331378 ChEMBL_ID
CHEBI:78539 CHEBI
DB13166 DRUGBANK_ID
CHEMBL2105776 ChEMBL_ID
92400 PUBCHEM_CID
6462 IUPHAR_LIGAND_ID
C044958 MESH_SUPPLEMENTAL_RECORD_UI
DB08766 DRUGBANK_ID

Pharmaceutical products:

None