zofenopril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
angiotensin-converting enzyme inhibitors	2866	81872-10-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: zofenopril zofenopril calcium SQ-26991 SQ. 26,991 zofenopril potassium	Molecular weight: 429.55 Formula: C22H23NO4S2 CLOGP: 4.02 LIPINSKI: 0 HAC: 5 HDO: 1 TPSA: 74.68 ALOGS: -5.14 ROTB: 8

Molecule

Description

Molfile Inchi Smiles

Synonyms:

zofenopril
zofenopril calcium
SQ-26991
SQ. 26,991
zofenopril potassium

Molecular weight: 429.55
Formula: C22H23NO4S2
CLOGP: 4.02
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 74.68
ALOGS: -5.14
ROTB: 8

Drug dosage:

Dose	Unit	Route
30	mg	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug interaction	90.75	51.75	54	1075	229077	63258816
Bradycardia	75.42	51.75	33	1096	73194	63414699
Hyponatraemic syndrome	66.24	51.75	11	1118	544	63487349
Vascular stent thrombosis	60.03	51.75	11	1118	966	63486927

Showing 1 to 4 of 4 entries

Previous1Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug interaction	123.89	39.38	74	811	225872	34730174
Initial insomnia	48.43	39.38	12	873	3112	34952934
Blood glucose fluctuation	45.35	39.38	12	873	4032	34952014

Showing 1 to 3 of 3 entries

Previous1Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug interaction	194.51	33.48	125	1960	415058	79327245
Bradycardia	78.49	33.48	47	2038	135510	79606793
Hyponatraemic syndrome	64.58	33.48	12	2073	768	79741535
Hypertensive crisis	45.63	33.48	18	2067	20752	79721551
Hallucination, gustatory	42.25	33.48	6	2079	68	79742235
Dry mouth	41.93	33.48	27	2058	87992	79654311
Vascular stent thrombosis	41.17	33.48	11	2074	3699	79738604
Blood glucose fluctuation	38.96	33.48	12	2073	6670	79735633
Initial insomnia	38.52	33.48	12	2073	6926	79735377
Psychogenic visual disorder	37.63	33.48	5	2080	33	79742270

Showing 1 to 10 of 14 entries

Previous1 2Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	C09AA15	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain
ATC	C09BA15	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics
CHEBI has role	CHEBI:35457	ACE inhibitor
CHEBI has role	CHEBI:35620	vasodilator agents
CHEBI has role	CHEBI:35623	anticonvulsants
CHEBI has role	CHEBI:50266	Prodrugs
CHEBI has role	CHEBI:68494	apoptosis inhibitors
CHEBI has role	CHEBI:77307	cardioprotective agents
CHEBI has role	CHEBI:49103	drug metabolites
MeSH PA	D000806	Angiotensin-Converting Enzyme Inhibitors

Showing 1 to 10 of 14 entries

Previous1 2Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.94	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Angiotensin-converting enzyme	Enzyme	P12821	ACE_HUMAN	INHIBITOR	IC50	9.40	CHEMBL	SCIENTIFIC LITERATURE
Angiotensin-converting enzyme	Enzyme		ACE_RABIT		Ki	9.40	CHEMBL
Angiotensin-converting enzyme	Enzyme		ACE_RAT		IC50	8.10	CHEMBL

Showing 1 to 3 of 3 entries

Previous1Next

External reference:

Show entries

Search:

ID	Source
ZED	PDB_CHEM_ID
008183	NDDF
008184	NDDF
259493	RXNORM
290ZY759PI	UNII
3034048	PUBCHEM_CID
4G4WDK2YBS	UNII
5535	INN_ID
6462	IUPHAR_LIGAND_ID
6463	IUPHAR_LIGAND_ID

Showing 1 to 10 of 30 entries

Previous1 2 3Next

Pharmaceutical products:

None