zofenopril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 2866 81872-10-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zofenopril
  • zofenopril calcium
  • SQ-26991
  • SQ. 26,991
  • zofenopril potassium
  • Molecular weight: 429.55
  • Formula: C22H23NO4S2
  • CLOGP: 4.68
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 74.68
  • ALOGS: -5.14
  • ROTB: 8

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 69.14 49.40 32 982 66266 46618782
Drug interaction 64.75 49.40 45 969 203049 46481999
Hyponatraemic syndrome 63.34 49.40 11 1003 581 46684467
Vascular stent thrombosis 59.10 49.40 11 1003 860 46684188

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 86.43 46.99 53 591 199515 29752319
Initial insomnia 52.65 46.99 12 632 2577 29949257
Blood glucose fluctuation 48.51 46.99 12 632 3649 29948185

Pharmacologic Action:

SourceCodeDescription
ATC C09AA15 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
ATC C09BA15 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and diuretics
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors
CHEBI has role CHEBI:35457 ace inhibitor
CHEBI has role CHEBI:35620 vasodilator
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:50266 prodrugs
CHEBI has role CHEBI:68494 type i programmed cell-death inhibitors
CHEBI has role CHEBI:77307 cardioprotective agents
CHEBI has role CHEBI:49103 drug metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.94 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 9.40 CHEMBL SCIENTIFIC LITERATURE
Angiotensin-converting enzyme Enzyme Ki 9.40 CHEMBL
Angiotensin-converting enzyme Enzyme IC50 8.10 CHEMBL

External reference:

IDSource
D03767 KEGG_DRUG
81938-43-4 SECONDARY_CAS_RN
75176-37-3 SECONDARY_CAS_RN
C0143376 UMLSCUI
C0085065 UMLSCUI
CHEBI:78539 CHEBI
CHEBI:82602 CHEBI
CHEMBL2105776 ChEMBL_ID
CHEMBL331378 ChEMBL_ID
CHEMBL16332 ChEMBL_ID
C044958 MESH_SUPPLEMENTAL_RECORD_UI
5535 INN_ID
6599 INN_ID
290ZY759PI UNII
4G4WDK2YBS UNII
3033690 PUBCHEM_CID
3034048 PUBCHEM_CID
6462 IUPHAR_LIGAND_ID
6463 IUPHAR_LIGAND_ID
DB13166 DRUGBANK_ID
DB08766 DRUGBANK_ID
259493 RXNORM
008183 NDDF
008184 NDDF
703340007 SNOMEDCT_US
703341006 SNOMEDCT_US
703342004 SNOMEDCT_US
703662000 SNOMEDCT_US
703663005 SNOMEDCT_US

Pharmaceutical products:

None