zofenopril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin-converting enzyme inhibitors | 2866 | 81872-10-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 30 | mg | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug interaction | 90.75 | 51.75 | 54 | 1075 | 229077 | 63258816 |
| Bradycardia | 75.42 | 51.75 | 33 | 1096 | 73194 | 63414699 |
| Hyponatraemic syndrome | 66.24 | 51.75 | 11 | 1118 | 544 | 63487349 |
| Vascular stent thrombosis | 60.03 | 51.75 | 11 | 1118 | 966 | 63486927 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug interaction | 123.89 | 39.38 | 74 | 811 | 225872 | 34730174 |
| Initial insomnia | 48.43 | 39.38 | 12 | 873 | 3112 | 34952934 |
| Blood glucose fluctuation | 45.35 | 39.38 | 12 | 873 | 4032 | 34952014 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug interaction | 194.51 | 33.48 | 125 | 1960 | 415058 | 79327245 |
| Bradycardia | 78.49 | 33.48 | 47 | 2038 | 135510 | 79606793 |
| Hyponatraemic syndrome | 64.58 | 33.48 | 12 | 2073 | 768 | 79741535 |
| Hypertensive crisis | 45.63 | 33.48 | 18 | 2067 | 20752 | 79721551 |
| Hallucination, gustatory | 42.25 | 33.48 | 6 | 2079 | 68 | 79742235 |
| Dry mouth | 41.93 | 33.48 | 27 | 2058 | 87992 | 79654311 |
| Vascular stent thrombosis | 41.17 | 33.48 | 11 | 2074 | 3699 | 79738604 |
| Blood glucose fluctuation | 38.96 | 33.48 | 12 | 2073 | 6670 | 79735633 |
| Initial insomnia | 38.52 | 33.48 | 12 | 2073 | 6926 | 79735377 |
| Psychogenic visual disorder | 37.63 | 33.48 | 5 | 2080 | 33 | 79742270 |
| Hallucination, olfactory | 37.18 | 33.48 | 7 | 2078 | 481 | 79741822 |
| Muscle contracture | 36.09 | 33.48 | 9 | 2076 | 2308 | 79739995 |
| Syncope | 34.31 | 33.48 | 32 | 2053 | 179417 | 79562886 |
| Apraxia | 34.19 | 33.48 | 9 | 2076 | 2858 | 79739445 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C09AA15 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
| ATC | C09BA15 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics |
| MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
| CHEBI has role | CHEBI:35457 | ACE inhibitor |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:35623 | anticonvulsants |
| CHEBI has role | CHEBI:50266 | Prodrugs |
| CHEBI has role | CHEBI:68494 | apoptosis inhibitors |
| CHEBI has role | CHEBI:77307 | cardioprotective agents |
| CHEBI has role | CHEBI:49103 | drug metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.94 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 9.40 | CHEMBL | SCIENTIFIC LITERATURE | |||
| Angiotensin-converting enzyme | Enzyme | Ki | 9.40 | CHEMBL | |||||
| Angiotensin-converting enzyme | Enzyme | IC50 | 8.10 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D03767 | KEGG_DRUG |
| C0078836 | UMLSCUI |
| CHEBI:78539 | CHEBI |
| CHEBI:82602 | CHEBI |
| ZED | PDB_CHEM_ID |
| CHEMBL331378 | ChEMBL_ID |
| DB13166 | DRUGBANK_ID |
| C044958 | MESH_SUPPLEMENTAL_RECORD_UI |
| 92400 | PUBCHEM_CID |
| 6462 | IUPHAR_LIGAND_ID |
| 5535 | INN_ID |
| 81938-43-4 | SECONDARY_CAS_RN |
| 290ZY759PI | UNII |
| DB08766 | DRUGBANK_ID |
| 259493 | RXNORM |
| 008183 | NDDF |
| 008184 | NDDF |
| 703340007 | SNOMEDCT_US |
| 703341006 | SNOMEDCT_US |
| 703342004 | SNOMEDCT_US |
| 703662000 | SNOMEDCT_US |
| 703663005 | SNOMEDCT_US |
| C0085065 | UMLSCUI |
| CHEMBL2105776 | ChEMBL_ID |
| CHEMBL16332 | ChEMBL_ID |
| 6599 | INN_ID |
| 75176-37-3 | SECONDARY_CAS_RN |
| 3034048 | PUBCHEM_CID |
| 6463 | IUPHAR_LIGAND_ID |
| 4G4WDK2YBS | UNII |
Pharmaceutical products:
None