lercanidipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 4157 100427-26-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lercanidipine hydrochloride
  • lercanidipine
  • masnidipine
  • zanidip
  • lercanidipine HCl
  • Molecular weight: 611.74
  • Formula: C36H41N3O6
  • CLOGP: 8
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -6.59
  • ROTB: 14

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 10 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70 49
kinase-selectivity-class AXL,BRAF,GRK2,PDK4,STK33,TEK 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 662.12 16.11 591 22686 319796 90285374
Hyponatraemia 478.54 16.11 341 22936 133197 90471973
Hyperkalaemia 241.81 16.11 170 23107 64794 90540376
Hypotension 205.33 16.11 328 22949 325069 90280101
Fall 188.80 16.11 395 22882 481415 90123755
Hypokalaemia 178.18 16.11 193 23084 130923 90474247
Lactic acidosis 160.27 16.11 120 23157 50343 90554827
Hypertensive crisis 139.56 16.11 75 23202 17709 90587461
Anaemia 135.32 16.11 287 22990 352515 90252655
Pemphigoid 131.12 16.11 58 23219 8968 90596202
Drug interaction 130.10 16.11 245 23032 276208 90328962
Cholestasis 125.80 16.11 91 23186 36208 90568962
General physical health deterioration 123.79 16.11 278 22999 354837 90250333
Bradycardia 99.38 16.11 115 23162 83732 90521438
Product prescribing error 98.63 16.11 73 23204 30072 90575098
Body mass index abnormal 97.22 16.11 25 23252 714 90604456
Atrial fibrillation 92.81 16.11 141 23136 133470 90471700
Pain 90.80 16.11 74 23203 996267 89608903
Cardiac failure 89.79 16.11 125 23152 109371 90495799
Abdominal discomfort 87.81 16.11 10 23267 477318 90127852
Eosinophilia 84.27 16.11 65 23212 28468 90576702
Infusion related reaction 83.98 16.11 6 23271 416774 90188396
Serositis 82.92 16.11 25 23252 1292 90603878
Central nervous system lupus 82.08 16.11 25 23252 1338 90603832
Labelled drug-drug interaction medication error 80.79 16.11 49 23228 14533 90590637
Cell death 80.12 16.11 30 23247 3025 90602145
Drug ineffective 77.89 16.11 149 23128 1384149 89221021
Sprue-like enteropathy 77.22 16.11 22 23255 931 90604239
Hepatocellular injury 76.98 16.11 62 23215 28896 90576274
Arthropathy 71.72 16.11 6 23271 366236 90238934
Labile hypertension 70.58 16.11 18 23259 497 90604673
Anuria 70.00 16.11 45 23232 14773 90590397
Ischaemic stroke 68.76 16.11 52 23225 22114 90583056
Pallor 68.06 16.11 62 23215 34103 90571067
Sopor 66.01 16.11 53 23224 24591 90580579
Drug hypersensitivity 65.42 16.11 19 23258 463590 90141580
Glossodynia 63.75 16.11 5 23272 321774 90283396
Sinusitis 63.53 16.11 7 23270 343081 90262089
Toxic skin eruption 62.66 16.11 43 23234 15731 90589439
Treatment failure 62.29 16.11 4 23273 303924 90301246
Swelling 59.43 16.11 17 23260 419041 90186129
Therapeutic product effect decreased 58.89 16.11 3 23274 277568 90327602
Haematuria 55.56 16.11 56 23221 34881 90570289
Rhabdomyolysis 55.25 16.11 67 23210 51189 90553981
Rheumatoid arthritis 54.67 16.11 13 23264 362601 90242569
Alopecia 54.03 16.11 30 23247 495041 90110129
Giant cell arteritis 52.31 16.11 22 23255 3007 90602163
Nasopharyngitis 51.63 16.11 20 23257 407084 90198086
Lupus nephritis 51.33 16.11 25 23252 4807 90600363
Syncope 50.78 16.11 108 23169 132555 90472615
Vasoplegia syndrome 50.49 16.11 21 23256 2793 90602377
Maternal exposure during pregnancy 50.32 16.11 15 23262 360048 90245122
Renal impairment 50.17 16.11 94 23183 105327 90499843
Electrocardiogram QT prolonged 49.62 16.11 76 23201 72380 90532790
Hepatic enzyme increased 48.68 16.11 16 23261 360720 90244450
Medication error 48.67 16.11 82 23195 84570 90520600
Orthostatic hypotension 47.25 16.11 56 23221 41771 90563399
Product dose omission issue 46.94 16.11 9 23268 291678 90313492
Mobility decreased 46.70 16.11 5 23272 250729 90354441
Helicobacter infection 46.43 16.11 3 23274 226847 90378323
Hallucination, visual 46.17 16.11 42 23235 23050 90582120
Tongue oedema 45.60 16.11 24 23253 5430 90599740
Mononeuropathy multiplex 45.11 16.11 12 23265 392 90604778
Creutzfeldt-Jakob disease 43.38 16.11 10 23267 178 90604992
Duodenal ulcer perforation 42.28 16.11 4 23273 221284 90383886
Renal artery stenosis 41.61 16.11 17 23260 2160 90603010
Product monitoring error 40.87 16.11 21 23256 4523 90600647
Tachycardia 40.52 16.11 110 23167 157563 90447607
Hypocalcaemia 40.25 16.11 52 23225 42316 90562854
Diabetic metabolic decompensation 39.88 16.11 16 23261 1941 90603229
Hyperlactacidaemia 39.78 16.11 20 23257 4116 90601054
Haematemesis 39.50 16.11 46 23231 33680 90571490
Discomfort 39.11 16.11 11 23266 274324 90330846
Haematoma 38.79 16.11 49 23228 38999 90566171
Hypersensitivity 38.56 16.11 36 23241 454641 90150529
Cranial nerve disorder 38.48 16.11 12 23265 695 90604475
Therapeutic drug monitoring analysis not performed 38.34 16.11 14 23263 1315 90603855
Small fibre neuropathy 38.20 16.11 12 23265 712 90604458
Impaired healing 38.16 16.11 7 23270 234192 90370978
Autonomic neuropathy 37.37 16.11 14 23263 1413 90603757
Drug intolerance 37.30 16.11 36 23241 447555 90157615
Renin increased 37.24 16.11 9 23268 198 90604972
Peripheral ischaemia 36.52 16.11 21 23256 5646 90599524
Renal failure 36.30 16.11 94 23183 130913 90474257
Cerebral haematoma 36.22 16.11 19 23258 4270 90600900
Metabolic acidosis 36.16 16.11 57 23220 55619 90549551
Inappropriate antidiuretic hormone secretion 36.14 16.11 34 23243 19471 90585699
Migraine 34.93 16.11 4 23273 190388 90414782
Haematochezia 34.69 16.11 64 23213 70849 90534321
Disturbance in attention 34.50 16.11 51 23226 47058 90558112
Rash maculo-papular 33.93 16.11 47 23230 40886 90564284
Haematoma muscle 33.84 16.11 14 23263 1836 90603334
Blood creatinine increased 33.67 16.11 78 23199 101308 90503862
Altered state of consciousness 33.62 16.11 41 23236 31491 90573679
Endometrial adenocarcinoma 33.56 16.11 13 23264 1437 90603733
Presyncope 33.34 16.11 41 23236 31764 90573406
Exposure during pregnancy 33.17 16.11 10 23267 238400 90366770
Product use issue 33.15 16.11 22 23255 329897 90275273
Confusional state 32.86 16.11 190 23087 386015 90219155
Medical observation 32.56 16.11 8 23269 189 90604981
Asthma 32.20 16.11 11 23266 242149 90363021
Injury 31.93 16.11 6 23271 197343 90407827
Myopathy 31.86 16.11 27 23250 13491 90591679
Epileptic encephalopathy 31.61 16.11 9 23268 380 90604790
Infection 31.48 16.11 28 23249 362066 90243104
Wrong product administered 30.69 16.11 21 23256 7644 90597526
Death 30.25 16.11 44 23233 456507 90148663
Weight increased 29.98 16.11 38 23239 417889 90187281
Walking disability 29.69 16.11 12 23265 1483 90603687
Stevens-Johnson syndrome 29.40 16.11 37 23240 29339 90575831
Clumsiness 29.24 16.11 14 23263 2593 90602577
Lower respiratory tract infection 29.07 16.11 14 23263 250645 90354525
Helplessness 29.04 16.11 8 23269 299 90604871
Necrotising myositis 28.69 16.11 10 23267 821 90604349
Acute pulmonary oedema 28.66 16.11 22 23255 9558 90595612
Hallucination, gustatory 28.63 16.11 6 23271 67 90605103
Blister 28.44 16.11 15 23262 254983 90350187
Wrong patient received product 28.22 16.11 15 23262 3462 90601708
Abdominal pain 28.20 16.11 186 23091 395535 90209635
Arthralgia 28.17 16.11 104 23173 778418 89826752
Retroperitoneal fibrosis 28.14 16.11 8 23269 336 90604834
Stomatitis 28.03 16.11 18 23259 274680 90330490
Shock haemorrhagic 27.93 16.11 24 23253 12221 90592949
Hepatic cytolysis 27.90 16.11 37 23240 30879 90574291
Bladder transitional cell carcinoma 27.86 16.11 10 23267 894 90604276
Intestinal villi atrophy 27.78 16.11 8 23269 352 90604818
Mental status changes postoperative 27.53 16.11 7 23270 191 90604979
Type 2 diabetes mellitus 27.42 16.11 9 23268 203235 90401935
Poisoning deliberate 27.27 16.11 27 23250 16459 90588711
Pulmonary vein occlusion 26.99 16.11 6 23271 90 90605080
Gout 26.76 16.11 27 23250 16832 90588338
Lip oedema 26.75 16.11 16 23261 4623 90600547
Interstitial lung disease 26.72 16.11 60 23217 76345 90528825
Coma 26.48 16.11 58 23219 72574 90532596
Renal tubular necrosis 26.25 16.11 25 23252 14530 90590640
Mixed liver injury 26.14 16.11 19 23258 7604 90597566
Language disorder 26.02 16.11 13 23264 2639 90602531
Confusion postoperative 25.88 16.11 7 23270 244 90604926
Convulsive threshold lowered 25.74 16.11 8 23269 458 90604712
Fracture 25.66 16.11 30 23247 22046 90583124
Polyuria 25.63 16.11 21 23256 10019 90595151
Radiation fibrosis 25.59 16.11 5 23272 38 90605132
Spontaneous haematoma 25.45 16.11 10 23267 1148 90604022
Polyneuropathy 25.40 16.11 28 23249 19313 90585857
Ill-defined disorder 25.27 16.11 8 23269 184883 90420287
Incorrect dosage administered 25.09 16.11 13 23264 2847 90602323
Blood cholesterol increased 25.08 16.11 11 23266 208001 90397169
Suicide attempt 25.02 16.11 58 23219 75341 90529829
Hypercalcaemia 24.97 16.11 37 23240 34203 90570967
Hyperlipasaemia 24.89 16.11 9 23268 822 90604348
Oesophageal food impaction 24.78 16.11 7 23270 287 90604883
Wrong patient 24.62 16.11 9 23268 848 90604322
Musculoskeletal stiffness 24.51 16.11 24 23253 296508 90308662
Crush syndrome 24.44 16.11 7 23270 302 90604868
Status epilepticus 24.23 16.11 27 23250 18847 90586323
Joint swelling 24.10 16.11 59 23218 503241 90101929
Therapeutic drug monitoring analysis incorrectly performed 23.76 16.11 7 23270 334 90604836
Asthenia 23.74 16.11 225 23052 533526 90071644
Contusion 23.59 16.11 18 23259 251198 90353972
Polymyalgia rheumatica 23.22 16.11 15 23262 4962 90600208
Nocturia 23.19 16.11 20 23257 10235 90594935
Arterial spasm 23.16 16.11 5 23272 65 90605105
Immune-mediated pancreatitis 23.05 16.11 7 23270 371 90604799
Peripheral sensorimotor neuropathy 22.99 16.11 11 23266 2034 90603136
Optic neuropathy 22.92 16.11 12 23265 2686 90602484
Myelitis 22.82 16.11 11 23266 2067 90603103
Accidental overdose 22.74 16.11 32 23245 28241 90576929
Neutropenia 22.72 16.11 116 23161 224788 90380382
Product use in unapproved indication 22.65 16.11 32 23245 336204 90268966
Haemorrhagic thyroid cyst 22.64 16.11 4 23273 16 90605154
Gait inability 22.55 16.11 5 23272 146451 90458719
Dehydration 22.29 16.11 104 23173 194343 90410827
Liver injury 22.23 16.11 8 23269 170559 90434611
Contraindicated product prescribed 22.20 16.11 10 23267 1612 90603558
Erythrosis 22.19 16.11 5 23272 80 90605090
Contraindicated product administered 22.04 16.11 30 23247 320109 90285061
Thrombocytopenia 22.03 16.11 109 23168 208616 90396554
Oedema 22.01 16.11 12 23265 200283 90404887
Prothrombin time shortened 21.86 16.11 11 23266 2267 90602903
Acute generalised exanthematous pustulosis 21.85 16.11 22 23255 13681 90591489
Rhonchi 21.80 16.11 12 23265 2966 90602204
Degenerative mitral valve disease 21.75 16.11 4 23273 21 90605149
Arrhythmia 21.71 16.11 39 23238 42293 90562877
White blood cell count decreased 21.51 16.11 8 23269 167101 90438069
Lymphocele 21.40 16.11 8 23269 803 90604367
Transaminases increased 21.33 16.11 36 23241 37156 90568014
Injection site pain 21.23 16.11 9 23268 173690 90431480
Pseudophaeochromocytoma 20.86 16.11 5 23272 106 90605064
Depression 20.86 16.11 28 23249 300573 90304597
Tubulointerstitial nephritis 20.85 16.11 29 23248 25314 90579856
Gamma-glutamyltransferase increased 20.80 16.11 36 23241 37916 90567254
Lichenoid keratosis 20.76 16.11 11 23266 2523 90602647
Night sweats 20.64 16.11 4 23273 128762 90476408
Hypovolaemic shock 20.59 16.11 16 23261 7078 90598092
Hyperglycaemic hyperosmolar nonketotic syndrome 20.54 16.11 9 23268 1360 90603810
Eastern Cooperative Oncology Group performance status worsened 20.50 16.11 10 23267 1929 90603241
Neuroendocrine tumour of the lung metastatic 20.27 16.11 5 23272 120 90605050
Wound 20.24 16.11 29 23248 302951 90302219
Hallucination, olfactory 19.75 16.11 6 23271 318 90604852
Prerenal failure 19.67 16.11 10 23267 2105 90603065
Therapeutic product effect incomplete 19.37 16.11 13 23264 193883 90411287
Myasthenia gravis crisis 19.29 16.11 8 23269 1056 90604114
Oesophageal achalasia 19.13 16.11 7 23270 661 90604509
Obstructive pancreatitis 19.00 16.11 7 23270 674 90604496
Faecaloma 18.97 16.11 18 23259 10413 90594757
Peripheral sensory neuropathy 18.84 16.11 17 23260 9233 90595937
Oedema peripheral 18.81 16.11 122 23155 257793 90347377
Lymphopenia 18.55 16.11 26 23251 22855 90582315
Arthritis 18.42 16.11 10 23267 167305 90437865
Immune-mediated myositis 18.40 16.11 10 23267 2411 90602759
Frontotemporal dementia 18.35 16.11 6 23271 405 90604765
Morbid thoughts 18.31 16.11 7 23270 747 90604423
Traumatic haematoma 18.21 16.11 9 23268 1786 90603384
Disorientation 18.13 16.11 37 23240 44077 90561093
Adverse event 18.09 16.11 4 23273 117414 90487756
Off label use 17.93 16.11 189 23088 1102063 89503107
Overdose 17.81 16.11 84 23193 157625 90447545
Pharyngeal haematoma 17.81 16.11 4 23273 63 90605107
Dysaesthesia 17.80 16.11 13 23264 5242 90599928
Subcutaneous haematoma 17.80 16.11 9 23268 1874 90603296
Splenic haemorrhage 17.56 16.11 5 23272 211 90604959
Hyperparathyroidism primary 17.53 16.11 6 23271 466 90604704
Ultrasound liver abnormal 17.53 16.11 4 23273 68 90605102
Accelerated hypertension 17.39 16.11 6 23271 478 90604692
Claudication of jaw muscles 17.36 16.11 4 23273 71 90605099
Postural tremor 17.36 16.11 6 23271 480 90604690
Electrocardiogram abnormal 17.28 16.11 17 23260 10281 90594889
Adenocarcinoma metastatic 17.23 16.11 5 23272 226 90604944
Aortic valve incompetence 17.21 16.11 14 23263 6610 90598560
Infected lymphocele 17.19 16.11 5 23272 228 90604942
Photosensitivity reaction 17.14 16.11 22 23255 17785 90587385
Dermatitis exfoliative generalised 17.08 16.11 13 23264 5580 90599590
Purpura 17.04 16.11 20 23257 14758 90590412
Thyroid haemorrhage 17.01 16.11 4 23273 78 90605092
Electrocardiogram T wave inversion 16.94 16.11 11 23266 3672 90601498
Abnormal loss of weight 16.85 16.11 14 23263 6809 90598361
Clonus 16.76 16.11 13 23264 5737 90599433
Pancreatic failure 16.69 16.11 8 23269 1484 90603686
Hyperglycaemia 16.68 16.11 39 23238 50931 90554239
Cholestatic liver injury 16.63 16.11 11 23266 3786 90601384
Constipation 16.56 16.11 126 23151 280269 90324901
Miosis 16.56 16.11 16 23261 9468 90595702
Somnolence 16.55 16.11 101 23176 208983 90396187
Peripheral artery thrombosis 16.44 16.11 9 23268 2201 90602969
Respiratory distress 16.40 16.11 33 23244 38913 90566257
Cardiac septal hypertrophy 16.32 16.11 5 23272 273 90604897
Small intestinal haemorrhage 16.21 16.11 9 23268 2262 90602908
Hypothermia 16.19 16.11 20 23257 15555 90589615
Tremor 16.16 16.11 80 23197 153093 90452077
Oesophagitis 16.11 16.11 21 23256 17228 90587942

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 377.24 14.64 645 19646 366692 42234352
Hyperkalaemia 125.08 14.64 172 20119 80286 42520758
Lactic acidosis 120.11 14.64 127 20164 45134 42555910
General physical health deterioration 92.70 14.64 215 20076 151031 42450013
Death 81.96 14.64 63 20228 471122 42129922
Pemphigoid 70.72 14.64 52 20239 11415 42589629
Syncope 69.47 14.64 149 20142 99257 42501787
Vascular purpura 65.24 14.64 28 20263 2158 42598886
Metabolic acidosis 60.55 14.64 97 20194 51761 42549283
Drug ineffective 60.35 14.64 132 20159 630065 41970979
Hypomagnesaemia 60.18 14.64 71 20220 28417 42572627
Hepatic vein dilatation 58.85 14.64 15 20276 216 42600828
Product dose omission issue 57.97 14.64 4 20287 154361 42446683
Liver palpable 55.06 14.64 15 20276 283 42600761
Inappropriate antidiuretic hormone secretion 54.08 14.64 52 20239 16489 42584555
Drug interaction 52.89 14.64 259 20032 266740 42334304
Narrow anterior chamber angle 52.03 14.64 12 20279 110 42600934
Rash maculo-papular 52.02 14.64 76 20215 37427 42563617
Eosinophilia 50.54 14.64 70 20221 32829 42568215
Oedema peripheral 47.86 14.64 158 20133 135918 42465126
Bradycardia 47.40 14.64 117 20174 85367 42515677
Hyponatraemia 47.17 14.64 130 20161 101332 42499712
Nodular melanoma 46.32 14.64 12 20279 185 42600859
Diverticulitis intestinal perforated 45.96 14.64 13 20278 283 42600761
Atrial enlargement 45.65 14.64 16 20275 713 42600331
Hypoglycaemia 44.42 14.64 92 20199 59762 42541282
Hypotension 40.77 14.64 235 20056 257396 42343648
Inferior vena cava dilatation 40.13 14.64 15 20276 805 42600239
Sprue-like enteropathy 39.75 14.64 14 20277 633 42600411
Hypokalaemia 39.57 14.64 98 20193 71623 42529421
Ventricular enlargement 39.01 14.64 14 20277 669 42600375
Rubber sensitivity 37.68 14.64 12 20279 396 42600648
Hypertensive crisis 37.03 14.64 34 20257 10172 42590872
Meningorrhagia 36.02 14.64 9 20282 119 42600925
Renal oncocytoma 36.02 14.64 10 20281 203 42600841
Lens dislocation 35.22 14.64 9 20282 131 42600913
Renal impairment 34.37 14.64 123 20168 110105 42490939
Supine hypertension 34.23 14.64 11 20280 374 42600670
Electrocardiogram abnormal 33.36 14.64 32 20259 10113 42590931
Respiratory alkalosis 33.18 14.64 18 20273 2326 42598718
Interstitial lung disease 33.01 14.64 97 20194 78365 42522679
Transient aphasia 32.59 14.64 12 20279 617 42600427
Completed suicide 32.21 14.64 4 20287 96461 42504583
Product prescribing error 32.06 14.64 50 20241 26062 42574982
Hypocalcaemia 31.91 14.64 54 20237 30119 42570925
Platelet count decreased 30.34 14.64 14 20277 138567 42462477
Haematochezia 30.30 14.64 78 20213 58358 42542686
Retinal artery occlusion 28.57 14.64 16 20275 2199 42598845
Haematoma 28.12 14.64 49 20242 27974 42573070
Torsade de pointes 28.05 14.64 27 20264 8567 42592477
Dyspnoea at rest 27.86 14.64 20 20271 4229 42596815
Intestinal transit time decreased 27.78 14.64 7 20284 96 42600948
Pancreatitis acute 27.77 14.64 54 20237 33510 42567534
Cardiac failure chronic 27.34 14.64 28 20263 9573 42591471
Electrocardiogram QT prolonged 26.95 14.64 66 20225 47879 42553165
Peptic ulcer perforation 26.75 14.64 9 20282 354 42600690
Disease progression 26.43 14.64 18 20273 143638 42457406
Pain 26.09 14.64 48 20243 244800 42356244
Hepatic cytolysis 25.72 14.64 46 20245 26798 42574246
Coronary artery stenosis 25.52 14.64 28 20263 10351 42590693
Agranulocytosis 25.02 14.64 49 20242 30563 42570481
Cholestasis 24.92 14.64 51 20240 32828 42568216
Acute respiratory distress syndrome 24.37 14.64 48 20243 30060 42570984
Toxicity to various agents 24.34 14.64 45 20246 229091 42371953
Mesenteric artery thrombosis 23.89 14.64 10 20281 724 42600320
Calculus bladder 23.60 14.64 12 20279 1358 42599686
Presyncope 23.58 14.64 40 20251 22347 42578697
Nephroangiosclerosis 23.32 14.64 7 20284 189 42600855
Abdominal compartment syndrome 22.97 14.64 11 20280 1094 42599950
Cerebral haematoma 22.95 14.64 20 20271 5590 42595454
Glomerulonephritis membranous 22.88 14.64 12 20279 1448 42599596
Nasopharyngitis 22.64 14.64 6 20285 83990 42517054
Implant site inflammation 22.50 14.64 6 20285 104 42600940
Hemiplegia 22.47 14.64 23 20268 7856 42593188
Systemic infection 22.19 14.64 19 20272 5186 42595858
Anaemia 22.13 14.64 217 20074 280061 42320983
Retinal vein occlusion 22.05 14.64 13 20278 1968 42599076
Renal failure 21.95 14.64 130 20161 143596 42457448
Acute coronary syndrome 21.88 14.64 31 20260 14834 42586210
Drug hypersensitivity 21.81 14.64 10 20281 99379 42501665
Mesenteric vein thrombosis 21.60 14.64 10 20281 922 42600122
Acetonaemia 21.35 14.64 7 20284 254 42600790
Post thrombotic syndrome 21.33 14.64 6 20285 128 42600916
Renal artery arteriosclerosis 21.29 14.64 5 20286 50 42600994
Vertigo 21.16 14.64 49 20242 34298 42566746
Renal artery restenosis 21.06 14.64 4 20287 12 42601032
Constipation 20.90 14.64 28 20263 162263 42438781
Laryngeal leukoplakia 20.85 14.64 5 20286 55 42600989
Drug abuse 20.82 14.64 12 20279 104759 42496285
Dyslipidaemia 20.76 14.64 24 20267 9394 42591650
Hospitalisation 20.63 14.64 5 20286 74325 42526719
Product monitoring error 20.62 14.64 17 20274 4406 42596638
Duplicate therapy error 20.48 14.64 7 20284 289 42600755
Melaena 20.37 14.64 52 20239 38694 42562350
Dermatitis exfoliative generalised 20.35 14.64 19 20272 5805 42595239
Concomitant disease aggravated 20.20 14.64 20 20271 6566 42594478
Cerebral haemorrhage 20.18 14.64 52 20239 38914 42562130
Diarrhoea 20.05 14.64 319 19972 460530 42140514
Wrong drug 19.99 14.64 6 20285 162 42600882
C3 glomerulopathy 19.99 14.64 6 20285 162 42600882
Cardiac failure congestive 19.76 14.64 8 20283 85594 42515450
Necrotising myositis 19.67 14.64 10 20281 1131 42599913
Coma 19.52 14.64 63 20228 53491 42547553
Oesophageal ulcer haemorrhage 18.72 14.64 7 20284 376 42600668
Angioedema 18.32 14.64 53 20238 42424 42558620
Hyperlactacidaemia 18.27 14.64 16 20275 4500 42596544
Pneumonia 18.23 14.64 122 20169 422027 42179017
Renal cyst 17.93 14.64 23 20268 10016 42591028
Injection site pain 17.88 14.64 3 20288 57795 42543249
Musculoskeletal stiffness 17.87 14.64 3 20288 57762 42543282
Anti factor VIII antibody positive 17.80 14.64 5 20286 106 42600938
Asthma 17.67 14.64 4 20287 62310 42538734
Inappropriate schedule of product administration 17.65 14.64 12 20279 95890 42505154
Intestinal resection 17.58 14.64 11 20280 1853 42599191
Heparin-induced thrombocytopenia test positive 17.34 14.64 5 20286 117 42600927
Cell death 17.30 14.64 13 20278 2946 42598098
Inappropriate affect 17.17 14.64 8 20283 748 42600296
Amyotrophy 17.13 14.64 7 20284 477 42600567
Autoimmune enteropathy 17.03 14.64 4 20287 40 42601004
Intermittent claudication 16.86 14.64 12 20279 2503 42598541
Dizziness 16.83 14.64 187 20104 249067 42351977
Bundle branch block right 16.77 14.64 20 20271 8086 42592958
Umbilical hernia repair 16.52 14.64 4 20287 46 42600998
Vasoplegia syndrome 16.27 14.64 12 20279 2643 42598401
Hypoglycaemic encephalopathy 16.16 14.64 6 20285 316 42600728
Basal ganglia haematoma 16.14 14.64 4 20287 51 42600993
Gallbladder enlargement 15.90 14.64 9 20282 1262 42599782
Body mass index abnormal 15.56 14.64 5 20286 170 42600874
Schizophrenia 15.53 14.64 22 20269 10528 42590516
Post procedural sepsis 15.46 14.64 6 20285 357 42600687
Ischaemic stroke 15.12 14.64 33 20258 22200 42578844
Drug intolerance 14.88 14.64 10 20281 80414 42520630
Hepatocellular injury 14.82 14.64 34 20257 23644 42577400
Traumatic haemothorax 14.69 14.64 6 20285 408 42600636
Vaccination failure 14.68 14.64 9 20282 1463 42599581

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 991.83 14.41 1209 40790 634221 109913079
Hyponatraemia 407.07 14.41 456 41543 217197 110330103
Hyperkalaemia 340.62 14.41 333 41666 135463 110411837
Lactic acidosis 258.05 14.41 241 41758 92570 110454730
Hypotension 220.06 14.41 560 41439 523289 110024011
General physical health deterioration 203.35 14.41 478 41521 424817 110122483
Pemphigoid 187.89 14.41 108 41891 19599 110527701
Hypokalaemia 165.64 14.41 269 41730 182179 110365121
Drug interaction 163.46 14.41 488 41511 499695 110047605
Fall 149.70 14.41 536 41463 602946 109944354
Bradycardia 136.68 14.41 226 41773 155291 110392009
Anaemia 132.28 14.41 482 41517 546604 110000696
Cholestasis 130.41 14.41 141 41858 64377 110482923
Eosinophilia 128.44 14.41 133 41866 57803 110489497
Hypertensive crisis 124.04 14.41 90 41909 24282 110523018
Syncope 120.78 14.41 249 41750 202287 110345013
Drug ineffective 117.78 14.41 252 41747 1520288 109027012
Sprue-like enteropathy 117.61 14.41 38 41961 1658 110545642
Product prescribing error 115.88 14.41 119 41880 51212 110496088
Pain 115.17 14.41 116 41883 954839 109592461
Body mass index abnormal 103.69 14.41 30 41969 898 110546402
Metabolic acidosis 100.03 14.41 154 41845 99590 110447710
Infusion related reaction 95.95 14.41 15 41984 381147 110166153
Nasopharyngitis 93.84 14.41 18 41981 394343 110152957
Arthropathy 92.10 14.41 4 41995 287518 110259782
Drug hypersensitivity 92.00 14.41 29 41970 454061 110093239
Inappropriate antidiuretic hormone secretion 88.47 14.41 85 41914 33766 110513534
Cell death 87.06 14.41 43 41956 5748 110541552
Rash maculo-papular 86.51 14.41 123 41876 74099 110473201
Abdominal discomfort 85.60 14.41 22 41977 393836 110153464
Product dose omission issue 84.87 14.41 11 41988 321771 110225529
Atrial fibrillation 78.56 14.41 228 41771 229414 110317886
Renal impairment 78.34 14.41 201 41798 188244 110359056
Hepatocellular injury 77.65 14.41 96 41903 50546 110496754
Maternal exposure during pregnancy 77.08 14.41 5 41994 254878 110292422
Death 76.30 14.41 92 41907 698777 109848523
Anuria 74.99 14.41 67 41932 24274 110523026
Sinusitis 73.92 14.41 12 41987 296676 110250624
Hypocalcaemia 72.77 14.41 106 41893 65260 110482040
Central nervous system lupus 72.64 14.41 25 41974 1328 110545972
Completed suicide 72.58 14.41 5 41994 242376 110304924
Electrocardiogram QT prolonged 72.13 14.41 140 41859 108820 110438480
Treatment failure 71.85 14.41 10 41989 277224 110270076
Ischaemic stroke 71.09 14.41 83 41916 41180 110506120
Oedema peripheral 70.52 14.41 279 41720 328381 110218919
Alopecia 69.18 14.41 26 41973 364727 110182573
Renal failure 69.05 14.41 216 41783 226358 110320942
Serositis 69.02 14.41 25 41974 1544 110545756
Mobility decreased 67.99 14.41 6 41993 237416 110309884
Cardiac failure 67.77 14.41 190 41809 187436 110359864
Hypomagnesaemia 65.91 14.41 97 41902 60273 110487027
Haematoma 65.35 14.41 95 41904 58381 110488919
Haematochezia 65.27 14.41 139 41860 115385 110431915
Glossodynia 65.26 14.41 5 41994 221999 110325301
Swelling 64.95 14.41 26 41973 351015 110196285
Labelled drug-drug interaction medication error 64.45 14.41 67 41932 29235 110518065
Therapeutic product effect decreased 62.87 14.41 9 41990 244307 110302993
Vascular purpura 62.70 14.41 30 41969 3741 110543559
Psoriatic arthropathy 62.14 14.41 3 41996 196758 110350542
Hepatic vein dilatation 61.40 14.41 15 41984 229 110547071
Labile hypertension 60.91 14.41 18 41981 581 110546719
Rheumatoid arthritis 60.89 14.41 19 41980 299594 110247706
Toxic skin eruption 60.67 14.41 63 41936 27452 110519848
Vasoplegia syndrome 60.52 14.41 33 41966 5406 110541894
Interstitial lung disease 60.37 14.41 151 41848 139183 110408117
Presyncope 59.91 14.41 83 41916 48804 110498496
Pallor 59.16 14.41 89 41910 56378 110490922
Hypoglycaemia 59.14 14.41 134 41865 115970 110431330
Drug intolerance 57.86 14.41 42 41957 406470 110140830
Cerebral haematoma 56.97 14.41 39 41960 9593 110537707
Asthma 56.27 14.41 13 41986 250278 110297022
Liver palpable 55.98 14.41 15 41984 336 110546964
Hepatic cytolysis 55.17 14.41 85 41914 54968 110492332
Helicobacter infection 53.73 14.41 4 41995 181873 110365427
Electrocardiogram abnormal 52.75 14.41 49 41950 18660 110528640
Hyperlactacidaemia 52.47 14.41 35 41964 8251 110539049
Product monitoring error 52.46 14.41 36 41963 8891 110538409
Sopor 50.82 14.41 66 41933 36480 110510820
Narrow anterior chamber angle 50.22 14.41 12 41987 166 110547134
Orthostatic hypotension 48.65 14.41 89 41910 66160 110481140
Hypersensitivity 47.50 14.41 50 41949 403948 110143352
Injury 46.86 14.41 6 41993 177259 110370041
Necrotising myositis 46.16 14.41 20 41979 1982 110545318
Hepatic enzyme increased 45.85 14.41 33 41966 320859 110226441
Migraine 44.92 14.41 6 41993 171646 110375654
Fibromyalgia 44.66 14.41 6 41993 170903 110376397
Nodular melanoma 44.53 14.41 12 41987 275 110547025
Pancreatitis acute 44.29 14.41 81 41918 60193 110487107
Coma 44.16 14.41 121 41878 117748 110429552
Therapeutic product effect incomplete 44.04 14.41 15 41984 223790 110323510
Stomatitis 43.83 14.41 24 41975 270218 110277082
Musculoskeletal stiffness 43.74 14.41 26 41973 279796 110267504
Tongue oedema 43.17 14.41 31 41968 8225 110539075
Lupus nephritis 43.05 14.41 25 41974 4620 110542680
Renal artery stenosis 42.55 14.41 23 41976 3703 110543597
Giant cell arteritis 42.42 14.41 23 41976 3726 110543574
Blister 41.78 14.41 17 41982 227359 110319941
Creutzfeldt-Jakob disease 41.77 14.41 11 41988 230 110547070
Ventricular enlargement 41.30 14.41 14 41985 710 110546590
Inferior vena cava dilatation 41.02 14.41 15 41984 952 110546348
Arthralgia 41.00 14.41 155 41844 779477 109767823
Pericarditis 40.89 14.41 16 41983 219098 110328202
Medication error 40.30 14.41 109 41890 105257 110442043
Confusional state 40.20 14.41 310 41689 468370 110078930
Supine hypertension 39.17 14.41 12 41987 439 110546861
Exposure during pregnancy 39.04 14.41 8 41991 167416 110379884
Cardiac failure chronic 38.60 14.41 36 41963 13775 110533525
Cerebral haemorrhage 37.64 14.41 79 41920 64889 110482411
Weight increased 37.09 14.41 64 41935 419580 110127720
Renal oncocytoma 36.75 14.41 10 41989 238 110547062
Platelet count decreased 36.60 14.41 21 41978 230422 110316878
Discomfort 36.40 14.41 18 41981 214689 110332611
Product use issue 36.15 14.41 39 41960 311656 110235644
Dermatitis exfoliative generalised 35.39 14.41 31 41968 10941 110536359
Atrial enlargement 34.97 14.41 14 41985 1137 110546163
Injection site pain 34.87 14.41 12 41987 177910 110369390
Renal tubular necrosis 34.76 14.41 50 41949 30425 110516875
Melaena 34.60 14.41 79 41920 68678 110478622
Lens dislocation 34.46 14.41 9 41990 182 110547118
Clumsiness 34.12 14.41 20 41979 3760 110543540
Acute pulmonary oedema 34.07 14.41 37 41962 16959 110530341
Therapeutic drug monitoring analysis not performed 34.06 14.41 16 41983 1915 110545385
Transient aphasia 33.84 14.41 12 41987 697 110546603
Ill-defined disorder 33.59 14.41 9 41990 156844 110390456
Torsade de pointes 33.29 14.41 42 41957 22558 110524742
Duodenal ulcer perforation 33.11 14.41 13 41986 177687 110369613
Bursitis 32.92 14.41 5 41994 129913 110417387
Renin increased 32.90 14.41 10 41989 356 110546944
Medical observation 32.69 14.41 9 41990 224 110547076
Off label use 32.69 14.41 389 41610 1499796 109047504
Hallucination, visual 32.68 14.41 56 41943 39549 110507751
Haematuria 31.87 14.41 86 41913 82919 110464381
Lip oedema 31.87 14.41 25 41974 7575 110539725
Mononeuropathy multiplex 31.53 14.41 12 41987 851 110546449
Hyperlipasaemia 31.50 14.41 14 41985 1475 110545825
Product use in unapproved indication 31.28 14.41 78 41921 447299 110100001
Altered state of consciousness 31.00 14.41 68 41931 57558 110489742
Acute coronary syndrome 30.99 14.41 41 41958 23071 110524229
Endometrial adenocarcinoma 30.38 14.41 13 41986 1250 110546050
Depression 30.28 14.41 46 41953 317289 110230011
Cranial nerve disorder 30.04 14.41 13 41986 1284 110546016
Dyspnoea at rest 29.81 14.41 25 41974 8321 110538979
Small fibre neuropathy 29.78 14.41 12 41987 991 110546309
White blood cell count decreased 29.72 14.41 26 41973 229364 110317936
Hypovolaemic shock 29.68 14.41 32 41967 14551 110532749
Headache 29.56 14.41 205 41794 882172 109665128
Peripheral ischaemia 29.33 14.41 28 41971 11030 110536270
Tachycardia 29.18 14.41 166 41833 226479 110320821
Sleep disorder 28.92 14.41 20 41979 198624 110348676
Disease progression 28.89 14.41 30 41969 244004 110303296
Respiratory alkalosis 28.82 14.41 21 41978 5700 110541600
Polymyalgia rheumatica 28.77 14.41 22 41977 6420 110540880
Bundle branch block right 28.65 14.41 29 41970 12262 110535038
Shock haemorrhagic 28.61 14.41 43 41956 27204 110520096
Osteoarthritis 28.49 14.41 17 41982 182606 110364694
Memory impairment 28.45 14.41 20 41979 196924 110350376
Impaired healing 28.39 14.41 20 41979 196697 110350603
Acute generalised exanthematous pustulosis 28.38 14.41 38 41961 21626 110525674
Oesophagitis 28.30 14.41 44 41955 28671 110518629
Helplessness 28.30 14.41 9 41990 373 110546927
Systemic infection 28.23 14.41 26 41973 9793 110537507
Meningorrhagia 28.18 14.41 9 41990 378 110546922
Wrong patient received product 28.08 14.41 22 41977 6652 110540648
Tubulointerstitial nephritis 28.01 14.41 63 41936 54221 110493079
Agranulocytosis 27.86 14.41 68 41931 61692 110485608
Inappropriate schedule of product administration 27.72 14.41 22 41977 203615 110343685
Intestinal transit time decreased 27.68 14.41 7 41992 124 110547176
Coronary artery stenosis 27.67 14.41 30 41969 13728 110533572
Pulmonary vein occlusion 27.42 14.41 7 41992 129 110547171
Overdose 27.36 14.41 167 41832 233627 110313673
Obesity 27.30 14.41 5 41994 113346 110433954
Arthritis 26.99 14.41 15 41984 167571 110379729
Mesenteric artery thrombosis 26.92 14.41 11 41988 942 110546358
Amyotrophy 26.57 14.41 10 41989 688 110546612
Angioedema 26.46 14.41 90 41909 98410 110448890
Night sweats 26.31 14.41 9 41990 133974 110413326
Calculus bladder 26.22 14.41 13 41986 1751 110545549
Hallucination, gustatory 26.21 14.41 6 41993 68 110547232
Diabetic metabolic decompensation 26.02 14.41 17 41982 3872 110543428
Rhinorrhoea 25.90 14.41 4 41995 102662 110444638
Adverse event 25.78 14.41 5 41994 108804 110438496
Diabetes mellitus inadequate control 25.76 14.41 43 41956 29732 110517568
Arrhythmia 25.63 14.41 71 41928 69504 110477796
Hospitalisation 25.61 14.41 11 41988 142482 110404818
Type 2 diabetes mellitus 25.60 14.41 18 41981 177214 110370086
Renal cyst 25.55 14.41 33 41966 18139 110529161
Acute respiratory distress syndrome 25.53 14.41 60 41939 53138 110494162
Gait inability 25.37 14.41 10 41989 136366 110410934
Chronic kidney disease 25.33 14.41 75 41924 76216 110471084
Loss of personal independence in daily activities 24.79 14.41 13 41986 150007 110397293
Vertigo 24.77 14.41 81 41918 86789 110460511
Infection 24.65 14.41 64 41935 362136 110185164
Retinal artery occlusion 24.65 14.41 17 41982 4232 110543068
Atrioventricular block 24.28 14.41 31 41968 16846 110530454
Gout 24.20 14.41 47 41952 36519 110510781
Dyslipidaemia 24.04 14.41 30 41969 15935 110531365
Rhabdomyolysis 24.01 14.41 100 41899 120301 110426999
Asthenia 23.99 14.41 381 41618 688618 109858682
Hyperglycaemia 23.96 14.41 79 41920 85011 110462289
Cardiac failure congestive 23.63 14.41 14 41985 150986 110396314
Haematemesis 23.46 14.41 62 41937 59046 110488254
Oropharyngeal pain 23.44 14.41 11 41988 135265 110412035
Pneumonia 23.22 14.41 217 41782 876497 109670803
Radiation fibrosis 23.19 14.41 5 41994 42 110547258
Nephroangiosclerosis 23.17 14.41 8 41991 429 110546871
Epileptic encephalopathy 23.16 14.41 9 41990 676 110546624
Clonus 22.98 14.41 22 41977 8694 110538606
Atrioventricular block complete 22.98 14.41 33 41966 20049 110527251
Haematoma muscle 22.87 14.41 16 41983 4074 110543226
Insomnia 22.83 14.41 66 41933 360524 110186776
Suicide attempt 22.31 14.41 88 41911 103306 110443994
Blood creatinine increased 22.26 14.41 132 41867 182757 110364543
Retroperitoneal fibrosis 22.25 14.41 9 41990 751 110546549
Post procedural sepsis 22.18 14.41 9 41990 757 110546543
Spontaneous haematoma 22.10 14.41 12 41987 1949 110545351
Mixed liver injury 21.98 14.41 25 41974 12054 110535246
Renal artery restenosis 21.97 14.41 4 41995 12 110547288
Laryngeal leukoplakia 21.90 14.41 5 41994 56 110547244
Glomerulonephritis membranous 21.86 14.41 12 41987 1991 110545309
Walking disability 21.84 14.41 13 41986 2515 110544785
Hypercalcaemia 21.72 14.41 52 41947 46605 110500695
Therapeutic response decreased 21.70 14.41 5 41994 96494 110450806
Prerenal failure 21.63 14.41 16 41983 4443 110542857
Peptic ulcer perforation 21.45 14.41 9 41990 824 110546476
Therapy non-responder 21.40 14.41 17 41982 157290 110390010
Diarrhoea 21.13 14.41 574 41425 1138931 109408369
Haemorrhagic thyroid cyst 21.07 14.41 4 41995 16 110547284
Nocturia 21.04 14.41 29 41970 16961 110530339
Retinal vein occlusion 20.85 14.41 15 41984 3992 110543308
Stress 20.82 14.41 7 41992 105341 110441959
Dyspnoea 20.64 14.41 558 41441 1106314 109440986
Wrong product administered 20.48 14.41 23 41976 10937 110536363
Autonomic neuropathy 20.32 14.41 12 41987 2288 110545012
Cholestatic liver injury 20.18 14.41 19 41980 7357 110539943
Crush syndrome 20.05 14.41 7 41992 388 110546912
Mental status changes postoperative 20.03 14.41 6 41993 203 110547097
Intentional product use issue 19.94 14.41 40 41959 247866 110299434
Road traffic accident 19.77 14.41 8 41991 107390 110439910
Rubber sensitivity 19.76 14.41 12 41987 2406 110544894
Intermittent claudication 19.59 14.41 14 41985 3687 110543613
Abdominal compartment syndrome 19.54 14.41 11 41988 1916 110545384
Peritoneal cloudy effluent 19.50 14.41 8 41991 692 110546608
Duplicate therapy error 19.33 14.41 7 41992 432 110546868
Language disorder 19.13 14.41 14 41985 3824 110543476
Bundle branch block left 19.06 14.41 24 41975 12864 110534436
Anti factor VIII antibody positive 19.01 14.41 5 41994 104 110547196
Illness 19.00 14.41 4 41995 82167 110465133
Myelitis 18.98 14.41 13 41986 3200 110544100
Glomerular filtration rate decreased 18.90 14.41 37 41962 28919 110518381
Peripheral sensorimotor neuropathy 18.79 14.41 14 41985 3929 110543371
Accelerated hypertension 18.50 14.41 8 41991 789 110546511
Escherichia sepsis 18.25 14.41 21 41978 10251 110537049
Hypoaesthesia 18.12 14.41 60 41939 314163 110233137
Implant site inflammation 18.12 14.41 6 41993 283 110547017
Lower respiratory tract infection 18.08 14.41 41 41958 243065 110304235
Wound infection 18.06 14.41 7 41992 96458 110450842
Musculoskeletal pain 17.96 14.41 26 41973 182997 110364303
Pseudophaeochromocytoma 17.95 14.41 5 41994 130 110547170
Dehydration 17.70 14.41 173 41826 279338 110267962
Angina pectoris 17.68 14.41 58 41941 62237 110485063
Delusional disorder, unspecified type 17.64 14.41 8 41991 883 110546417
Acetonaemia 17.61 14.41 7 41992 558 110546742
Oesophageal food impaction 17.59 14.41 7 41992 560 110546740
Tachyphrenia 17.50 14.41 11 41988 2345 110544955
Intestinal villi atrophy 17.47 14.41 7 41992 570 110546730
Heparin-induced thrombocytopenia test positive 17.46 14.41 5 41994 144 110547156
Colitis ulcerative 17.41 14.41 4 41995 77359 110469941
Traumatic haematoma 17.22 14.41 11 41988 2410 110544890
Colitis microscopic 16.79 14.41 23 41976 13371 110533929
Cardiac arrest 16.75 14.41 130 41869 196623 110350677
Arterial spasm 16.73 14.41 5 41994 168 110547132
Confusion postoperative 16.70 14.41 6 41993 362 110546938
Jaundice 16.68 14.41 55 41944 59181 110488119
Incorrect dosage administered 16.67 14.41 13 41986 3905 110543395
Thrombocytopenia 16.60 14.41 204 41795 348681 110198619
Gamma-glutamyltransferase increased 16.44 14.41 56 41943 61253 110486047
Hypothermia 16.43 14.41 33 41966 26269 110521031
Convulsive threshold lowered 16.42 14.41 8 41991 1038 110546262
Wrong patient 16.42 14.41 9 41990 1490 110545810
Poisoning deliberate 16.41 14.41 33 41966 26298 110521002
Frontotemporal dementia 16.33 14.41 7 41992 676 110546624
Haemorrhagic stroke 16.28 14.41 23 41976 13766 110533534
Acute myocardial infarction 16.25 14.41 69 41930 83708 110463592
Ruptured cerebral aneurysm 16.22 14.41 7 41992 687 110546613
Renal dysplasia 16.14 14.41 4 41995 65 110547235
Urethral cancer 16.14 14.41 4 41995 65 110547235
Therapeutic drug monitoring analysis incorrectly performed 16.05 14.41 7 41992 705 110546595
Basal ganglia haematoma 16.03 14.41 4 41995 67 110547233
Bradyphrenia 16.02 14.41 21 41978 11707 110535593
Dyspnoea exertional 15.96 14.41 80 41919 103980 110443320
Immune-mediated pancreatitis 15.94 14.41 7 41992 717 110546583
Colitis 15.93 14.41 79 41920 102244 110445056
Blood phosphorus decreased 15.91 14.41 17 41982 7648 110539652
Renal artery arteriosclerosis 15.81 14.41 4 41995 71 110547229
Inflammation 15.69 14.41 31 41968 193207 110354093
Autoimmune enteropathy 15.60 14.41 4 41995 75 110547225
Keratitis 15.53 14.41 14 41985 5130 110542170
Product quality issue 15.51 14.41 5 41994 77294 110470006
Wrong drug 15.51 14.41 6 41993 445 110546855
Wound 15.50 14.41 42 41957 234395 110312905
Erythrosis 15.43 14.41 5 41994 220 110547080
Prescribed overdose 15.36 14.41 7 41992 87574 110459726
Knee arthroplasty 15.35 14.41 3 41996 64945 110482355
Myopathy 15.22 14.41 31 41968 24929 110522371
Swollen tongue 15.20 14.41 54 41945 60308 110486992
Obstructive pancreatitis 15.13 14.41 8 41991 1233 110546067
Glycosylated haemoglobin abnormal 15.10 14.41 6 41993 478 110546822
Rhonchi 15.04 14.41 13 41986 4505 110542795
Subcutaneous haematoma 14.97 14.41 11 41988 3025 110544275
Infected lymphocele 14.93 14.41 5 41994 244 110547056
Lichenoid keratosis 14.93 14.41 15 41984 6287 110541013
Intracranial mass 14.91 14.41 10 41989 2378 110544922
Pain in extremity 14.91 14.41 116 41883 487002 110060298
Febrile bone marrow aplasia 14.81 14.41 25 41974 17440 110529860
Cardiac failure acute 14.79 14.41 30 41969 24048 110523252
Blood cholesterol increased 14.70 14.41 30 41969 184755 110362545
Optic neuropathy 14.70 14.41 13 41986 4645 110542655
Drug reaction with eosinophilia and systemic symptoms 14.69 14.41 66 41933 82029 110465271
Photosensitivity reaction 14.68 14.41 31 41968 25558 110521742
Drug level above therapeutic 14.68 14.41 20 41979 11568 110535732
Cutaneous vasculitis 14.68 14.41 21 41978 12708 110534592
Concomitant disease aggravated 14.65 14.41 24 41975 16340 110530960
Somnolence 14.61 14.41 175 41824 297274 110250026
Claudication of jaw muscles 14.59 14.41 4 41995 98 110547202
Hyperparathyroidism primary 14.58 14.41 6 41993 523 110546777
Tongue neoplasm malignant stage unspecified 14.56 14.41 8 41991 1331 110545969
Contusion 14.55 14.41 43 41956 233318 110313982
Myocarditis 14.53 14.41 34 41965 30021 110517279
Crowned dens syndrome 14.53 14.41 3 41996 20 110547280
Basal ganglia haemorrhage 14.49 14.41 9 41990 1879 110545421
Septic shock 14.48 14.41 106 41893 157422 110389878
Vaccination failure 14.47 14.41 10 41989 2496 110544804

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA13 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C09BB02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09DB08 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent

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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.96 Basic
pKa2 2.09 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D01849 KEGG_DRUG
132866-11-6 SECONDARY_CAS_RN
C0526399 UMLSCUI
CHEBI:135930 CHEBI
CHEMBL250270 ChEMBL_ID
CHEMBL2106419 ChEMBL_ID
DB00528 DRUGBANK_ID
C060343 MESH_SUPPLEMENTAL_RECORD_UI
6971 INN_ID
V7XTJ4R0BH UNII
65866 PUBCHEM_CID
135056 RXNORM
007361 NDDF
007362 NDDF
356862006 SNOMEDCT_US
395768003 SNOMEDCT_US
395986007 SNOMEDCT_US

Pharmaceutical products:

None