lercanidipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 4157 100427-26-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lercanidipine hydrochloride
  • lercanidipine
  • masnidipine
  • zanidip
  • lercanidipine HCl
  • Molecular weight: 611.74
  • Formula: C36H41N3O6
  • CLOGP: 8
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -6.59
  • ROTB: 14

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 10 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 364.24 17.13 395 15030 227663 50362036
Hyponatraemia 282.83 17.13 234 15191 95905 50493794
General physical health deterioration 149.72 17.13 200 15225 142234 50447465
Hyperkalaemia 128.68 17.13 111 15314 47978 50541721
Hypotension 121.19 17.13 239 15186 235230 50354469
Fall 116.01 17.13 290 15135 334642 50255057
Lactic acidosis 105.85 17.13 85 15340 33270 50556429
Hypokalaemia 105.54 17.13 132 15293 87860 50501839
Cholestasis 105.48 17.13 76 15349 25325 50564374
Anaemia 80.39 17.13 212 15213 252244 50337455
Pallor 79.78 17.13 62 15363 23137 50566562
Hepatocellular injury 75.74 17.13 63 15362 25884 50563815
Eosinophilia 75.58 17.13 55 15370 18597 50571102
Cell death 73.29 17.13 27 15398 2188 50587511
Drug ineffective 71.87 17.13 87 15338 819246 49770453
Pemphigoid 70.69 17.13 35 15390 5872 50583827
Labile hypertension 69.12 17.13 18 15407 453 50589246
Confusional state 68.38 17.13 165 15260 185763 50403936
Vasoplegia syndrome 65.97 17.13 21 15404 1093 50588606
Atrial fibrillation 65.64 17.13 114 15311 101631 50488068
Pain 60.21 17.13 53 15372 578850 50010849
Product prescribing error 57.27 17.13 49 15376 20912 50568787
Labelled drug-drug interaction medication error 56.87 17.13 37 15388 10440 50579259
Bradycardia 53.54 17.13 81 15344 64345 50525354
Ischaemic stroke 53.48 17.13 42 15383 15906 50573793
Drug interaction 51.07 17.13 155 15270 199466 50390233
Hypertensive crisis 47.06 17.13 36 15389 13118 50576581
Drug hypersensitivity 46.31 17.13 10 15415 251000 50338699
Death 45.78 17.13 21 15404 325358 50264341
Abdominal discomfort 45.31 17.13 8 15417 231633 50358066
Sprue-like enteropathy 44.38 17.13 13 15412 510 50589189
Rheumatoid arthritis 44.28 17.13 5 15420 202545 50387154
Creutzfeldt-Jakob disease 44.26 17.13 10 15415 135 50589564
Sopor 41.59 17.13 40 15385 19839 50569860
Infusion related reaction 40.22 17.13 3 15422 169554 50420145
Hyperlactacidaemia 40.16 17.13 18 15407 2415 50587284
Medication error 39.81 17.13 52 15373 36052 50553647
Swelling 39.14 17.13 7 15418 200865 50388834
Anuria 38.53 17.13 30 15395 11214 50578485
Toxic skin eruption 38.52 17.13 30 15395 11221 50578478
Renin increased 38.07 17.13 9 15416 150 50589549
Haematemesis 35.45 17.13 43 15382 27682 50562017
Sinusitis 35.35 17.13 5 15420 170553 50419146
Tachycardia 34.97 17.13 87 15338 99676 50490023
Product dose omission issue 34.55 17.13 7 15418 183831 50405868
Immune-mediated pancreatitis 34.54 17.13 7 15418 54 50589645
Arthropathy 34.24 17.13 4 15421 157902 50431797
Orthostatic hypotension 33.34 17.13 43 15382 29438 50560261
Epileptic encephalopathy 33.14 17.13 9 15416 267 50589432
Haematochezia 32.91 17.13 50 15375 39832 50549867
Electrocardiogram QT prolonged 31.95 17.13 57 15368 51829 50537870
Joint swelling 31.24 17.13 18 15407 245268 50344431
Alopecia 31.18 17.13 18 15407 245029 50344670
Diabetic metabolic decompensation 31.15 17.13 13 15412 1467 50588232
Treatment failure 31.09 17.13 3 15422 137634 50452065
Necrotising myositis 30.29 17.13 9 15416 371 50589328
Disturbance in attention 29.94 17.13 42 15383 31144 50558555
Cerebral haematoma 29.69 17.13 16 15409 3195 50586504
Walking disability 29.36 17.13 12 15413 1284 50588415
Helplessness 28.94 17.13 8 15417 254 50589445
Myopathy 28.35 17.13 23 15402 9116 50580583
Hallucination, gustatory 27.61 17.13 6 15419 67 50589632
Spontaneous haematoma 27.56 17.13 10 15415 776 50588923
Contraindicated product prescribed 27.42 17.13 10 15415 787 50588912
Tongue oedema 27.02 17.13 16 15409 3823 50585876
Mental status changes postoperative 26.88 17.13 7 15418 176 50589523
Rhabdomyolysis 26.80 17.13 45 15380 38982 50550717
Convulsive threshold lowered 26.76 17.13 8 15417 337 50589362
Renal artery stenosis 26.42 17.13 12 15413 1660 50588039
Nasopharyngitis 26.25 17.13 13 15412 192914 50396785
Confusion postoperative 26.16 17.13 7 15418 196 50589503
Hyperglycaemic hyperosmolar nonketotic syndrome 25.96 17.13 9 15416 611 50589088
Radiation fibrosis 25.22 17.13 5 15420 34 50589665
Pulmonary vein occlusion 25.10 17.13 6 15419 105 50589594
Altered state of consciousness 24.84 17.13 32 15393 21878 50567821
Poisoning deliberate 24.73 17.13 20 15405 7892 50581807
Polyneuropathy 24.60 17.13 24 15401 12107 50577592
Cardiac failure 24.24 17.13 64 15361 75976 50513723
Retroperitoneal fibrosis 23.62 17.13 7 15418 286 50589413
Arthralgia 23.47 17.13 63 15362 438639 50151060
Prothrombin time shortened 23.34 17.13 11 15414 1656 50588043
Rhonchi 22.75 17.13 12 15413 2295 50587404
Arterial spasm 22.68 17.13 5 15420 60 50589639
Hypovolaemic shock 22.62 17.13 16 15409 5172 50584527
Suicide attempt 22.36 17.13 49 15376 51683 50538016
Intestinal villi atrophy 22.26 17.13 6 15419 173 50589526
Miosis 21.98 17.13 17 15408 6293 50583406
Acute pulmonary oedema 21.94 17.13 18 15407 7249 50582450
Adenocarcinoma metastatic 21.64 17.13 5 15420 75 50589624
Pseudophaeochromocytoma 21.52 17.13 5 15420 77 50589622
Ultrasound liver abnormal 21.22 17.13 4 15421 20 50589679
Arrhythmia 21.17 17.13 37 15388 33095 50556604
Degenerative mitral valve disease 21.06 17.13 4 15421 21 50589678
Postural tremor 21.01 17.13 6 15419 215 50589484
Hallucination, olfactory 20.82 17.13 6 15419 222 50589477
White blood cell count decreased 20.80 17.13 5 15420 116717 50472982
Product monitoring error 20.72 17.13 12 15413 2752 50586947
Haematoma 20.71 17.13 35 15390 30475 50559224
Metabolic acidosis 20.58 17.13 40 15385 38785 50550914
Rash maculo-papular 20.02 17.13 32 15393 26609 50563090
Shock haemorrhagic 19.78 17.13 18 15407 8326 50581373
Presyncope 19.48 17.13 30 15395 24168 50565531
Frontotemporal dementia 19.38 17.13 6 15419 285 50589414
Traumatic haematoma 19.20 17.13 9 15416 1338 50588361
Overdose 18.84 17.13 70 15355 99657 50490042
Tinnitus 18.73 17.13 32 15393 28100 50561599
Somnolence 18.68 17.13 95 15330 154890 50434809
Cerebral salt-wasting syndrome 18.63 17.13 4 15421 42 50589657
Wrong product administered 17.71 17.13 14 15411 5346 50584353
Hepatic enzyme increased 17.59 17.13 10 15415 137370 50452329
Gamma-glutamyltransferase increased 17.53 17.13 32 15393 29591 50560108
Blood creatinine increased 17.45 17.13 57 15368 76103 50513596

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 200.59 16.20 388 12489 264879 29296771
General physical health deterioration 76.53 16.20 150 12727 102707 29458943
Lactic acidosis 72.30 16.20 77 12800 30170 29531480
Hyperkalaemia 65.63 16.20 105 12772 61287 29500363
Hepatic vein dilatation 60.12 16.20 15 12862 217 29561433
Atrial enlargement 59.18 16.20 16 12861 322 29561328
Liver palpable 56.80 16.20 15 12862 275 29561375
Death 54.23 16.20 42 12835 342042 29219608
Pemphigoid 53.36 16.20 36 12841 7545 29554105
Narrow anterior chamber angle 53.20 16.20 12 12865 109 29561541
Hyponatraemia 51.90 16.20 100 12777 67533 29494117
Metabolic acidosis 48.10 16.20 70 12807 37592 29524058
Inappropriate antidiuretic hormone secretion 45.74 16.20 38 12839 10894 29550756
Ventricular enlargement 45.55 16.20 14 12863 450 29561200
Inferior vena cava dilatation 44.25 16.20 15 12862 662 29560988
Drug ineffective 41.35 16.20 59 12818 363111 29198539
Hypomagnesaemia 40.89 16.20 44 12833 17424 29544226
Lens dislocation 38.76 16.20 9 12868 94 29561556
Syncope 38.32 16.20 99 12778 81272 29480378
Vascular purpura 36.87 16.20 16 12861 1387 29560263
Meningorrhagia 36.68 16.20 9 12868 121 29561529
Hypokalaemia 35.79 16.20 72 12805 50131 29511519
Supine hypertension 33.13 16.20 10 12867 302 29561348
Retinal artery occlusion 31.54 16.20 15 12862 1608 29560042
Haematochezia 31.22 16.20 57 12820 36926 29524724
Product dose omission issue 31.11 16.20 3 12874 96380 29465270
Hypertensive crisis 30.20 16.20 26 12851 7822 29553828
Bradycardia 30.01 16.20 79 12798 65550 29496100
Sprue-like enteropathy 29.75 16.20 10 12867 430 29561220
Dyspnoea at rest 29.39 16.20 18 12859 3196 29558454
Pancreatitis acute 29.22 16.20 44 12833 24341 29537309
Electrocardiogram QT prolonged 28.38 16.20 54 12823 36083 29525567
Coronary artery stenosis 28.22 16.20 26 12851 8547 29553103
Abdominal compartment syndrome 26.82 16.20 11 12866 828 29560822
Mesenteric artery thrombosis 26.27 16.20 9 12868 410 29561240
Completed suicide 26.20 16.20 4 12873 90242 29471408
Renal artery arteriosclerosis 25.28 16.20 5 12872 22 29561628
Rash maculo-papular 25.17 16.20 41 12836 24248 29537402
Hepatocellular injury 24.98 16.20 38 12839 21205 29540445
Cholestasis 24.85 16.20 40 12837 23422 29538228
Mesenteric vein thrombosis 24.75 16.20 9 12868 489 29561161
Wrong drug 24.57 16.20 6 12871 79 29561571
Nephroangiosclerosis 24.56 16.20 7 12870 172 29561478
Drug abuse 24.47 16.20 3 12874 79880 29481770
Cardiac failure chronic 24.02 16.20 21 12856 6446 29555204
Hemiplegia 23.67 16.20 21 12856 6573 29555077
Vasoplegia syndrome 23.53 16.20 12 12865 1496 29560154
Implant site inflammation 22.93 16.20 6 12871 106 29561544
Interstitial lung disease 22.92 16.20 66 12811 57652 29503998
Cell death 22.76 16.20 13 12864 2031 29559619
Oedema peripheral 22.50 16.20 97 12780 103460 29458190
Ischaemic stroke 22.30 16.20 31 12846 15946 29545704
Presyncope 22.14 16.20 31 12846 16058 29545592
Post thrombotic syndrome 21.81 16.20 6 12871 129 29561521
Renal artery restenosis 21.42 16.20 4 12873 12 29561638
Bundle branch block right 21.39 16.20 20 12857 6697 29554953
Laryngeal leukoplakia 21.30 16.20 5 12872 55 29561595
Eosinophilia 21.08 16.20 36 12841 22125 29539525
Hypoglycaemia 20.88 16.20 57 12820 48289 29513361
Respiratory alkalosis 20.84 16.20 11 12866 1472 29560178
Coma 20.64 16.20 50 12827 39400 29522250
Agranulocytosis 20.62 16.20 34 12843 20306 29541344
Retinal vein occlusion 20.55 16.20 11 12866 1514 29560136
Cerebral haematoma 20.22 16.20 16 12861 4280 29557370
Drug interaction 20.21 16.20 151 12726 197234 29364416
Anti factor VIII antibody positive 19.81 16.20 5 12872 76 29561574
Autoimmune enteropathy 19.80 16.20 4 12873 20 29561630
Product monitoring error 19.67 16.20 13 12864 2632 29559018
Torsade de pointes 19.62 16.20 19 12858 6642 29555008
Hyperlactacidaemia 19.52 16.20 13 12864 2665 29558985
Cholangiocarcinoma 19.14 16.20 9 12868 941 29560709
Gallbladder enlargement 19.13 16.20 9 12868 942 29560708
Electrolyte imbalance 19.01 16.20 24 12853 11250 29550400
Platelet count decreased 18.99 16.20 11 12866 104661 29456989
Splenomegaly 18.89 16.20 26 12851 13253 29548397
Haematoma 18.61 16.20 35 12842 23177 29538473
Bradyphrenia 18.36 16.20 15 12862 4199 29557451
Schizophrenia 17.99 16.20 18 12859 6547 29555103
Glycosylated haemoglobin abnormal 17.94 16.20 5 12872 113 29561537
Traumatic haemothorax 17.87 16.20 6 12871 257 29561393
Urethral cancer 17.87 16.20 4 12873 35 29561615
Bundle branch block left 17.36 16.20 16 12861 5261 29556389
Livedo reticularis 17.34 16.20 11 12866 2077 29559573
Hypoglycaemic encephalopathy 17.34 16.20 6 12871 282 29561368
Body mass index abnormal 17.17 16.20 5 12872 133 29561517
Hypotension 16.78 16.20 143 12734 194211 29367439
Basal ganglia haematoma 16.65 16.20 4 12873 49 29561601

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 490.55 14.27 763 26671 448477 64022821
Hyponatraemia 265.52 14.27 321 27113 148018 64323280
General physical health deterioration 210.38 14.27 339 27095 204086 64267212
Hyperkalaemia 168.09 14.27 211 27223 100918 64370380
Lactic acidosis 151.02 14.27 157 27277 61253 64410045
Pemphigoid 113.36 14.27 70 27364 12916 64458382
Cholestasis 110.79 14.27 115 27319 44757 64426541
Hypokalaemia 107.64 14.27 189 27245 121714 64349584
Hypotension 104.22 14.27 377 27057 380597 64090701
Drug ineffective 99.97 14.27 127 27307 840120 63631178
Fall 89.29 14.27 382 27052 416444 64054854
Cell death 87.51 14.27 40 27394 4014 64467284
Hepatocellular injury 85.83 14.27 101 27333 45134 64426164
Eosinophilia 80.65 14.27 90 27344 37986 64433312
Completed suicide 78.92 14.27 4 27430 224410 64246888
Death 78.28 14.27 55 27379 482650 63988648
Vasoplegia syndrome 78.20 14.27 33 27401 2734 64468564
Pallor 72.59 14.27 86 27348 38695 64432603
Bradycardia 69.98 14.27 155 27279 118064 64353234
Sprue-like enteropathy 68.57 14.27 23 27411 1006 64470292
Pain 67.38 14.27 82 27352 553429 63917869
Anaemia 66.85 14.27 328 27106 378352 64092946
Ischaemic stroke 65.59 14.27 71 27363 28964 64442334
Metabolic acidosis 62.56 14.27 110 27324 70848 64400450
Labile hypertension 60.94 14.27 18 27416 516 64470782
Hypertensive crisis 60.50 14.27 55 27379 18193 64453105
Haematochezia 59.95 14.27 104 27330 66269 64405029
Hepatic vein dilatation 59.47 14.27 15 27419 233 64471065
Confusional state 57.06 14.27 241 27193 260903 64210395
Electrocardiogram QT prolonged 56.11 14.27 112 27322 79336 64391962
Liver palpable 54.47 14.27 15 27419 332 64470966
Inappropriate antidiuretic hormone secretion 52.98 14.27 56 27378 22233 64449065
Drug interaction 52.43 14.27 297 27137 361786 64109512
Hyperlactacidaemia 52.42 14.27 30 27404 4814 64466484
Nasopharyngitis 52.29 14.27 10 27424 196063 64275235
Product dose omission issue 51.79 14.27 10 27424 194737 64276561
Labelled drug-drug interaction medication error 51.68 14.27 55 27379 22007 64449291
Atrial fibrillation 50.64 14.27 174 27260 170915 64300383
Drug hypersensitivity 50.50 14.27 19 27415 237796 64233502
Syncope 49.91 14.27 164 27270 157471 64313827
Infusion related reaction 49.29 14.27 6 27428 164461 64306837
Narrow anterior chamber angle 49.28 14.27 12 27422 160 64471138
Product prescribing error 48.32 14.27 67 27367 35202 64436096
Sinusitis 47.16 14.27 4 27430 145924 64325374
Cerebral haematoma 46.23 14.27 32 27402 7153 64464145
Anuria 45.70 14.27 48 27386 18916 64452382
Swelling 45.29 14.27 7 27427 160211 64311087
Ventricular enlargement 44.22 14.27 14 27420 509 64470789
Inferior vena cava dilatation 43.00 14.27 15 27419 739 64470559
Rash maculo-papular 41.56 14.27 73 27361 46953 64424345
Presyncope 41.26 14.27 62 27372 35027 64436271
Atrial enlargement 41.02 14.27 14 27420 646 64470652
Oedema peripheral 39.78 14.27 186 27248 210131 64261167
Creutzfeldt-Jakob disease 38.69 14.27 10 27424 172 64471126
Rheumatoid arthritis 38.61 14.27 11 27423 164283 64307015
Arthropathy 37.28 14.27 4 27430 120963 64350335
Orthostatic hypotension 36.79 14.27 69 27365 46669 64424629
Product monitoring error 36.76 14.27 25 27409 5429 64465869
Renin increased 36.63 14.27 10 27424 214 64471084
Lens dislocation 36.55 14.27 9 27425 126 64471172
Supine hypertension 36.14 14.27 11 27423 350 64470948
Haematoma 36.06 14.27 68 27366 46182 64425116
Medication error 35.94 14.27 71 27363 49895 64421403
Interstitial lung disease 33.94 14.27 105 27329 97627 64373671
Vascular purpura 33.62 14.27 18 27416 2538 64468760
Abdominal discomfort 33.32 14.27 18 27416 182304 64288994
Treatment failure 33.24 14.27 5 27429 116811 64354487
Therapeutic product effect decreased 32.68 14.27 5 27429 115346 64355952
Alopecia 32.32 14.27 15 27419 165675 64305623
Acute pulmonary oedema 31.90 14.27 33 27401 12776 64458522
White blood cell count decreased 31.24 14.27 14 27420 157823 64313475
Hypovolaemic shock 30.28 14.27 29 27405 10237 64461061
Meningorrhagia 30.14 14.27 9 27425 268 64471030
Toxic skin eruption 30.03 14.27 39 27395 19245 64452053
Pancreatitis acute 29.74 14.27 60 27374 42795 64428503
Overdose 29.33 14.27 140 27294 159426 64311872
Hypomagnesaemia 29.19 14.27 55 27379 37321 64433977
Dyspnoea at rest 29.04 14.27 23 27411 6306 64464992
Helplessness 28.70 14.27 9 27425 317 64470981
Altered state of consciousness 28.64 14.27 55 27379 37847 64433451
Platelet count decreased 28.60 14.27 18 27416 167693 64303605
Immune-mediated pancreatitis 28.43 14.27 7 27427 98 64471200
Mesenteric artery thrombosis 27.88 14.27 10 27424 535 64470763
Shock haemorrhagic 27.78 14.27 35 27399 16756 64454542
Cardiac failure 27.19 14.27 120 27314 132253 64339045
Renal failure 26.86 14.27 150 27284 181538 64289760
Epileptic encephalopathy 26.67 14.27 9 27425 401 64470897
Suicide attempt 26.25 14.27 78 27356 70929 64400369
Retinal artery occlusion 26.23 14.27 16 27418 2887 64468411
Hypocalcaemia 26.10 14.27 56 27378 41697 64429601
Tongue oedema 25.85 14.27 21 27413 5969 64465329
Coma 25.79 14.27 89 27345 87526 64383772
Hallucination, gustatory 25.53 14.27 6 27428 68 64471230
Asthma 25.07 14.27 5 27429 95220 64376078
Nephroangiosclerosis 24.85 14.27 8 27426 307 64470991
Oropharyngeal pain 24.84 14.27 4 27430 88863 64382435
Bundle branch block right 24.76 14.27 26 27408 10243 64461055
Coronary artery stenosis 24.52 14.27 27 27407 11221 64460077
Tachycardia 24.48 14.27 127 27307 149452 64321846
Walking disability 24.24 14.27 13 27421 1838 64469460
Arthralgia 23.82 14.27 102 27332 442158 64029140
Haematemesis 23.80 14.27 58 27376 46941 64424357
Electrocardiogram abnormal 23.75 14.27 29 27405 13452 64457846
Cardiac failure congestive 23.70 14.27 13 27421 130567 64340731
Hypoglycaemia 23.64 14.27 88 27346 89804 64381494
Pneumonia 23.36 14.27 141 27293 559435 63911863
Radiation fibrosis 23.19 14.27 5 27429 37 64471261
Disease progression 23.08 14.27 16 27418 141664 64329634
Spontaneous haematoma 22.69 14.27 11 27423 1260 64470038
Diabetic metabolic decompensation 22.03 14.27 14 27420 2714 64468584
Cardiac failure chronic 21.99 14.27 23 27411 9018 64462280
Pulmonary vein occlusion 21.87 14.27 6 27428 131 64471167
Injection site pain 21.85 14.27 10 27424 111398 64359900
Bundle branch block left 21.72 14.27 24 27410 10010 64461288
Renal dysplasia 21.51 14.27 4 27430 12 64471286
Renal artery restenosis 21.51 14.27 4 27430 12 64471286
Abdominal compartment syndrome 21.47 14.27 11 27423 1417 64469881
Laryngeal leukoplakia 21.33 14.27 5 27429 56 64471242
Acute coronary syndrome 21.12 14.27 33 27401 19277 64452021
Renal artery stenosis 20.95 14.27 14 27420 2955 64468343
Mental status changes postoperative 20.73 14.27 6 27428 160 64471138
Drug intolerance 20.60 14.27 30 27404 187962 64283336
Dyspnoea 20.34 14.27 423 27011 718251 63753047
Sopor 19.95 14.27 41 27393 29620 64441678
Necrotising myositis 19.86 14.27 9 27425 885 64470413
Anti factor VIII antibody positive 19.80 14.27 5 27429 78 64471220
Mobility decreased 19.69 14.27 6 27428 85834 64385464
Hospitalisation 19.69 14.27 4 27430 75203 64396095
Intestinal villi atrophy 19.58 14.27 7 27427 371 64470927
Confusion postoperative 19.45 14.27 6 27428 200 64471098
Joint swelling 19.36 14.27 39 27395 215343 64255955
Therapeutic product effect incomplete 19.22 14.27 10 27424 103472 64367826
Angina pectoris 19.07 14.27 52 27382 45029 64426269
Pseudophaeochromocytoma 19.03 14.27 5 27429 92 64471206
Arthritis 18.97 14.27 6 27428 83808 64387490
Implant site inflammation 18.93 14.27 6 27428 219 64471079
Product use issue 18.89 14.27 22 27412 151693 64319605
Adenocarcinoma metastatic 18.78 14.27 5 27429 97 64471201
Wrong drug 18.60 14.27 6 27428 232 64471066
Traumatic haematoma 18.32 14.27 11 27423 1929 64469369
Atrioventricular block 18.24 14.27 24 27410 11991 64459307
Agranulocytosis 18.11 14.27 46 27388 38183 64433115
Renal artery arteriosclerosis 17.86 14.27 4 27430 36 64471262
Bradyphrenia 17.83 14.27 21 27413 9385 64461913
Autoimmune enteropathy 17.57 14.27 4 27430 39 64471259
Renal cyst 17.39 14.27 24 27410 12546 64458752
Frontotemporal dementia 17.35 14.27 7 27427 517 64470781
Hypersensitivity 17.29 14.27 36 27398 196416 64274882
Melaena 17.18 14.27 56 27378 53492 64417806
Migraine 17.12 14.27 3 27431 62674 64408624
Electrolyte imbalance 17.11 14.27 35 27399 25208 64446090
Hemiplegia 17.10 14.27 24 27410 12744 64458554
Glycosylated haemoglobin abnormal 17.04 14.27 5 27429 140 64471158
Neuropathy peripheral 16.96 14.27 15 27419 117510 64353788
Headache 16.93 14.27 144 27290 529323 63941975
Rhonchi 16.79 14.27 13 27421 3450 64467848
Retroperitoneal fibrosis 16.73 14.27 7 27427 568 64470730
Convulsive threshold lowered 16.71 14.27 8 27426 891 64470407
Urethral cancer 16.66 14.27 4 27430 50 64471248
Amyotrophy 16.54 14.27 7 27427 584 64470714
Arterial spasm 16.49 14.27 5 27429 157 64471141
Nocturia 16.48 14.27 22 27412 11143 64460155
Tongue neoplasm malignant stage unspecified 16.45 14.27 8 27426 922 64470376
Myopathy 16.34 14.27 28 27406 17652 64453646
Pneumocystis jirovecii infection 16.34 14.27 11 27423 2350 64468948
Musculoskeletal stiffness 16.29 14.27 17 27417 123189 64348109
Hyperglycaemia 16.29 14.27 60 27374 60908 64410390
Discomfort 16.27 14.27 7 27427 80871 64390427
Systemic infection 16.27 14.27 14 27420 4307 64466991
Basal ganglia haematoma 16.18 14.27 4 27430 57 64471241
Gallbladder enlargement 16.12 14.27 9 27425 1377 64469921
Livedo reticularis 16.04 14.27 13 27421 3684 64467614
Intermittent claudication 15.98 14.27 12 27422 3042 64468256
Fluid retention 15.96 14.27 3 27431 59603 64411695
Angioedema 15.81 14.27 60 27374 61761 64409537
Traumatic haemothorax 15.55 14.27 6 27428 394 64470904
Respiratory alkalosis 15.44 14.27 13 27421 3884 64467414
Prerenal failure 15.41 14.27 12 27422 3210 64468088
Torsade de pointes 15.39 14.27 27 27407 17336 64453962
Acute generalised exanthematous pustulosis 15.34 14.27 24 27410 14034 64457264
Intracranial mass 15.30 14.27 10 27424 2033 64469265
Claudication of jaw muscles 15.15 14.27 4 27430 75 64471223
Delusional disorder, unspecified type 15.09 14.27 7 27427 726 64470572
Oxygen saturation decreased 15.08 14.27 14 27420 107162 64364136
Body mass index abnormal 15.01 14.27 5 27429 214 64471084
C-reactive protein decreased 14.98 14.27 10 27424 2106 64469192
Miosis 14.97 14.27 23 27411 13243 64458055
Depression 14.97 14.27 35 27399 183256 64288042
Weight increased 14.94 14.27 44 27390 213304 64257994
Infected lymphocele 14.85 14.27 5 27429 221 64471077
Hallucination, olfactory 14.80 14.27 6 27428 449 64470849
Hallucination, visual 14.79 14.27 35 27399 27799 64443499
Poisoning deliberate 14.72 14.27 23 27411 13435 64457863
Splenic rupture 14.55 14.27 10 27424 2209 64469089
Prothrombin time shortened 14.48 14.27 11 27423 2838 64468460
White blood cell count increased 14.46 14.27 5 27429 66009 64405289
Seizure 14.33 14.27 31 27403 166861 64304437
Crowned dens syndrome 14.32 14.27 3 27431 19 64471279

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA13 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C09BB02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09DB08 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.96 Basic
pKa2 2.09 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D01849 KEGG_DRUG
132866-11-6 SECONDARY_CAS_RN
C0526399 UMLSCUI
CHEBI:31771 CHEBI
CHEMBL250270 ChEMBL_ID
CHEMBL2106419 ChEMBL_ID
DB00528 DRUGBANK_ID
C060343 MESH_SUPPLEMENTAL_RECORD_UI
6971 INN_ID
V7XTJ4R0BH UNII
65866 PUBCHEM_CID
135056 RXNORM
007361 NDDF
007362 NDDF
356862006 SNOMEDCT_US
395768003 SNOMEDCT_US
395986007 SNOMEDCT_US

Pharmaceutical products:

None