Stem definition | Drug id | CAS RN |
---|---|---|
calcium channel blockers, nifedipine derivatives | 4157 | 100427-26-7 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 10 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 364.24 | 17.13 | 395 | 15030 | 227663 | 50362036 |
Hyponatraemia | 282.83 | 17.13 | 234 | 15191 | 95905 | 50493794 |
General physical health deterioration | 149.72 | 17.13 | 200 | 15225 | 142234 | 50447465 |
Hyperkalaemia | 128.68 | 17.13 | 111 | 15314 | 47978 | 50541721 |
Hypotension | 121.19 | 17.13 | 239 | 15186 | 235230 | 50354469 |
Fall | 116.01 | 17.13 | 290 | 15135 | 334642 | 50255057 |
Lactic acidosis | 105.85 | 17.13 | 85 | 15340 | 33270 | 50556429 |
Hypokalaemia | 105.54 | 17.13 | 132 | 15293 | 87860 | 50501839 |
Cholestasis | 105.48 | 17.13 | 76 | 15349 | 25325 | 50564374 |
Anaemia | 80.39 | 17.13 | 212 | 15213 | 252244 | 50337455 |
Pallor | 79.78 | 17.13 | 62 | 15363 | 23137 | 50566562 |
Hepatocellular injury | 75.74 | 17.13 | 63 | 15362 | 25884 | 50563815 |
Eosinophilia | 75.58 | 17.13 | 55 | 15370 | 18597 | 50571102 |
Cell death | 73.29 | 17.13 | 27 | 15398 | 2188 | 50587511 |
Drug ineffective | 71.87 | 17.13 | 87 | 15338 | 819246 | 49770453 |
Pemphigoid | 70.69 | 17.13 | 35 | 15390 | 5872 | 50583827 |
Labile hypertension | 69.12 | 17.13 | 18 | 15407 | 453 | 50589246 |
Confusional state | 68.38 | 17.13 | 165 | 15260 | 185763 | 50403936 |
Vasoplegia syndrome | 65.97 | 17.13 | 21 | 15404 | 1093 | 50588606 |
Atrial fibrillation | 65.64 | 17.13 | 114 | 15311 | 101631 | 50488068 |
Pain | 60.21 | 17.13 | 53 | 15372 | 578850 | 50010849 |
Product prescribing error | 57.27 | 17.13 | 49 | 15376 | 20912 | 50568787 |
Labelled drug-drug interaction medication error | 56.87 | 17.13 | 37 | 15388 | 10440 | 50579259 |
Bradycardia | 53.54 | 17.13 | 81 | 15344 | 64345 | 50525354 |
Ischaemic stroke | 53.48 | 17.13 | 42 | 15383 | 15906 | 50573793 |
Drug interaction | 51.07 | 17.13 | 155 | 15270 | 199466 | 50390233 |
Hypertensive crisis | 47.06 | 17.13 | 36 | 15389 | 13118 | 50576581 |
Drug hypersensitivity | 46.31 | 17.13 | 10 | 15415 | 251000 | 50338699 |
Death | 45.78 | 17.13 | 21 | 15404 | 325358 | 50264341 |
Abdominal discomfort | 45.31 | 17.13 | 8 | 15417 | 231633 | 50358066 |
Sprue-like enteropathy | 44.38 | 17.13 | 13 | 15412 | 510 | 50589189 |
Rheumatoid arthritis | 44.28 | 17.13 | 5 | 15420 | 202545 | 50387154 |
Creutzfeldt-Jakob disease | 44.26 | 17.13 | 10 | 15415 | 135 | 50589564 |
Sopor | 41.59 | 17.13 | 40 | 15385 | 19839 | 50569860 |
Infusion related reaction | 40.22 | 17.13 | 3 | 15422 | 169554 | 50420145 |
Hyperlactacidaemia | 40.16 | 17.13 | 18 | 15407 | 2415 | 50587284 |
Medication error | 39.81 | 17.13 | 52 | 15373 | 36052 | 50553647 |
Swelling | 39.14 | 17.13 | 7 | 15418 | 200865 | 50388834 |
Anuria | 38.53 | 17.13 | 30 | 15395 | 11214 | 50578485 |
Toxic skin eruption | 38.52 | 17.13 | 30 | 15395 | 11221 | 50578478 |
Renin increased | 38.07 | 17.13 | 9 | 15416 | 150 | 50589549 |
Haematemesis | 35.45 | 17.13 | 43 | 15382 | 27682 | 50562017 |
Sinusitis | 35.35 | 17.13 | 5 | 15420 | 170553 | 50419146 |
Tachycardia | 34.97 | 17.13 | 87 | 15338 | 99676 | 50490023 |
Product dose omission issue | 34.55 | 17.13 | 7 | 15418 | 183831 | 50405868 |
Immune-mediated pancreatitis | 34.54 | 17.13 | 7 | 15418 | 54 | 50589645 |
Arthropathy | 34.24 | 17.13 | 4 | 15421 | 157902 | 50431797 |
Orthostatic hypotension | 33.34 | 17.13 | 43 | 15382 | 29438 | 50560261 |
Epileptic encephalopathy | 33.14 | 17.13 | 9 | 15416 | 267 | 50589432 |
Haematochezia | 32.91 | 17.13 | 50 | 15375 | 39832 | 50549867 |
Electrocardiogram QT prolonged | 31.95 | 17.13 | 57 | 15368 | 51829 | 50537870 |
Joint swelling | 31.24 | 17.13 | 18 | 15407 | 245268 | 50344431 |
Alopecia | 31.18 | 17.13 | 18 | 15407 | 245029 | 50344670 |
Diabetic metabolic decompensation | 31.15 | 17.13 | 13 | 15412 | 1467 | 50588232 |
Treatment failure | 31.09 | 17.13 | 3 | 15422 | 137634 | 50452065 |
Necrotising myositis | 30.29 | 17.13 | 9 | 15416 | 371 | 50589328 |
Disturbance in attention | 29.94 | 17.13 | 42 | 15383 | 31144 | 50558555 |
Cerebral haematoma | 29.69 | 17.13 | 16 | 15409 | 3195 | 50586504 |
Walking disability | 29.36 | 17.13 | 12 | 15413 | 1284 | 50588415 |
Helplessness | 28.94 | 17.13 | 8 | 15417 | 254 | 50589445 |
Myopathy | 28.35 | 17.13 | 23 | 15402 | 9116 | 50580583 |
Hallucination, gustatory | 27.61 | 17.13 | 6 | 15419 | 67 | 50589632 |
Spontaneous haematoma | 27.56 | 17.13 | 10 | 15415 | 776 | 50588923 |
Contraindicated product prescribed | 27.42 | 17.13 | 10 | 15415 | 787 | 50588912 |
Tongue oedema | 27.02 | 17.13 | 16 | 15409 | 3823 | 50585876 |
Mental status changes postoperative | 26.88 | 17.13 | 7 | 15418 | 176 | 50589523 |
Rhabdomyolysis | 26.80 | 17.13 | 45 | 15380 | 38982 | 50550717 |
Convulsive threshold lowered | 26.76 | 17.13 | 8 | 15417 | 337 | 50589362 |
Renal artery stenosis | 26.42 | 17.13 | 12 | 15413 | 1660 | 50588039 |
Nasopharyngitis | 26.25 | 17.13 | 13 | 15412 | 192914 | 50396785 |
Confusion postoperative | 26.16 | 17.13 | 7 | 15418 | 196 | 50589503 |
Hyperglycaemic hyperosmolar nonketotic syndrome | 25.96 | 17.13 | 9 | 15416 | 611 | 50589088 |
Radiation fibrosis | 25.22 | 17.13 | 5 | 15420 | 34 | 50589665 |
Pulmonary vein occlusion | 25.10 | 17.13 | 6 | 15419 | 105 | 50589594 |
Altered state of consciousness | 24.84 | 17.13 | 32 | 15393 | 21878 | 50567821 |
Poisoning deliberate | 24.73 | 17.13 | 20 | 15405 | 7892 | 50581807 |
Polyneuropathy | 24.60 | 17.13 | 24 | 15401 | 12107 | 50577592 |
Cardiac failure | 24.24 | 17.13 | 64 | 15361 | 75976 | 50513723 |
Retroperitoneal fibrosis | 23.62 | 17.13 | 7 | 15418 | 286 | 50589413 |
Arthralgia | 23.47 | 17.13 | 63 | 15362 | 438639 | 50151060 |
Prothrombin time shortened | 23.34 | 17.13 | 11 | 15414 | 1656 | 50588043 |
Rhonchi | 22.75 | 17.13 | 12 | 15413 | 2295 | 50587404 |
Arterial spasm | 22.68 | 17.13 | 5 | 15420 | 60 | 50589639 |
Hypovolaemic shock | 22.62 | 17.13 | 16 | 15409 | 5172 | 50584527 |
Suicide attempt | 22.36 | 17.13 | 49 | 15376 | 51683 | 50538016 |
Intestinal villi atrophy | 22.26 | 17.13 | 6 | 15419 | 173 | 50589526 |
Miosis | 21.98 | 17.13 | 17 | 15408 | 6293 | 50583406 |
Acute pulmonary oedema | 21.94 | 17.13 | 18 | 15407 | 7249 | 50582450 |
Adenocarcinoma metastatic | 21.64 | 17.13 | 5 | 15420 | 75 | 50589624 |
Pseudophaeochromocytoma | 21.52 | 17.13 | 5 | 15420 | 77 | 50589622 |
Ultrasound liver abnormal | 21.22 | 17.13 | 4 | 15421 | 20 | 50589679 |
Arrhythmia | 21.17 | 17.13 | 37 | 15388 | 33095 | 50556604 |
Degenerative mitral valve disease | 21.06 | 17.13 | 4 | 15421 | 21 | 50589678 |
Postural tremor | 21.01 | 17.13 | 6 | 15419 | 215 | 50589484 |
Hallucination, olfactory | 20.82 | 17.13 | 6 | 15419 | 222 | 50589477 |
White blood cell count decreased | 20.80 | 17.13 | 5 | 15420 | 116717 | 50472982 |
Product monitoring error | 20.72 | 17.13 | 12 | 15413 | 2752 | 50586947 |
Haematoma | 20.71 | 17.13 | 35 | 15390 | 30475 | 50559224 |
Metabolic acidosis | 20.58 | 17.13 | 40 | 15385 | 38785 | 50550914 |
Rash maculo-papular | 20.02 | 17.13 | 32 | 15393 | 26609 | 50563090 |
Shock haemorrhagic | 19.78 | 17.13 | 18 | 15407 | 8326 | 50581373 |
Presyncope | 19.48 | 17.13 | 30 | 15395 | 24168 | 50565531 |
Frontotemporal dementia | 19.38 | 17.13 | 6 | 15419 | 285 | 50589414 |
Traumatic haematoma | 19.20 | 17.13 | 9 | 15416 | 1338 | 50588361 |
Overdose | 18.84 | 17.13 | 70 | 15355 | 99657 | 50490042 |
Tinnitus | 18.73 | 17.13 | 32 | 15393 | 28100 | 50561599 |
Somnolence | 18.68 | 17.13 | 95 | 15330 | 154890 | 50434809 |
Cerebral salt-wasting syndrome | 18.63 | 17.13 | 4 | 15421 | 42 | 50589657 |
Wrong product administered | 17.71 | 17.13 | 14 | 15411 | 5346 | 50584353 |
Hepatic enzyme increased | 17.59 | 17.13 | 10 | 15415 | 137370 | 50452329 |
Gamma-glutamyltransferase increased | 17.53 | 17.13 | 32 | 15393 | 29591 | 50560108 |
Blood creatinine increased | 17.45 | 17.13 | 57 | 15368 | 76103 | 50513596 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 200.59 | 16.20 | 388 | 12489 | 264879 | 29296771 |
General physical health deterioration | 76.53 | 16.20 | 150 | 12727 | 102707 | 29458943 |
Lactic acidosis | 72.30 | 16.20 | 77 | 12800 | 30170 | 29531480 |
Hyperkalaemia | 65.63 | 16.20 | 105 | 12772 | 61287 | 29500363 |
Hepatic vein dilatation | 60.12 | 16.20 | 15 | 12862 | 217 | 29561433 |
Atrial enlargement | 59.18 | 16.20 | 16 | 12861 | 322 | 29561328 |
Liver palpable | 56.80 | 16.20 | 15 | 12862 | 275 | 29561375 |
Death | 54.23 | 16.20 | 42 | 12835 | 342042 | 29219608 |
Pemphigoid | 53.36 | 16.20 | 36 | 12841 | 7545 | 29554105 |
Narrow anterior chamber angle | 53.20 | 16.20 | 12 | 12865 | 109 | 29561541 |
Hyponatraemia | 51.90 | 16.20 | 100 | 12777 | 67533 | 29494117 |
Metabolic acidosis | 48.10 | 16.20 | 70 | 12807 | 37592 | 29524058 |
Inappropriate antidiuretic hormone secretion | 45.74 | 16.20 | 38 | 12839 | 10894 | 29550756 |
Ventricular enlargement | 45.55 | 16.20 | 14 | 12863 | 450 | 29561200 |
Inferior vena cava dilatation | 44.25 | 16.20 | 15 | 12862 | 662 | 29560988 |
Drug ineffective | 41.35 | 16.20 | 59 | 12818 | 363111 | 29198539 |
Hypomagnesaemia | 40.89 | 16.20 | 44 | 12833 | 17424 | 29544226 |
Lens dislocation | 38.76 | 16.20 | 9 | 12868 | 94 | 29561556 |
Syncope | 38.32 | 16.20 | 99 | 12778 | 81272 | 29480378 |
Vascular purpura | 36.87 | 16.20 | 16 | 12861 | 1387 | 29560263 |
Meningorrhagia | 36.68 | 16.20 | 9 | 12868 | 121 | 29561529 |
Hypokalaemia | 35.79 | 16.20 | 72 | 12805 | 50131 | 29511519 |
Supine hypertension | 33.13 | 16.20 | 10 | 12867 | 302 | 29561348 |
Retinal artery occlusion | 31.54 | 16.20 | 15 | 12862 | 1608 | 29560042 |
Haematochezia | 31.22 | 16.20 | 57 | 12820 | 36926 | 29524724 |
Product dose omission issue | 31.11 | 16.20 | 3 | 12874 | 96380 | 29465270 |
Hypertensive crisis | 30.20 | 16.20 | 26 | 12851 | 7822 | 29553828 |
Bradycardia | 30.01 | 16.20 | 79 | 12798 | 65550 | 29496100 |
Sprue-like enteropathy | 29.75 | 16.20 | 10 | 12867 | 430 | 29561220 |
Dyspnoea at rest | 29.39 | 16.20 | 18 | 12859 | 3196 | 29558454 |
Pancreatitis acute | 29.22 | 16.20 | 44 | 12833 | 24341 | 29537309 |
Electrocardiogram QT prolonged | 28.38 | 16.20 | 54 | 12823 | 36083 | 29525567 |
Coronary artery stenosis | 28.22 | 16.20 | 26 | 12851 | 8547 | 29553103 |
Abdominal compartment syndrome | 26.82 | 16.20 | 11 | 12866 | 828 | 29560822 |
Mesenteric artery thrombosis | 26.27 | 16.20 | 9 | 12868 | 410 | 29561240 |
Completed suicide | 26.20 | 16.20 | 4 | 12873 | 90242 | 29471408 |
Renal artery arteriosclerosis | 25.28 | 16.20 | 5 | 12872 | 22 | 29561628 |
Rash maculo-papular | 25.17 | 16.20 | 41 | 12836 | 24248 | 29537402 |
Hepatocellular injury | 24.98 | 16.20 | 38 | 12839 | 21205 | 29540445 |
Cholestasis | 24.85 | 16.20 | 40 | 12837 | 23422 | 29538228 |
Mesenteric vein thrombosis | 24.75 | 16.20 | 9 | 12868 | 489 | 29561161 |
Wrong drug | 24.57 | 16.20 | 6 | 12871 | 79 | 29561571 |
Nephroangiosclerosis | 24.56 | 16.20 | 7 | 12870 | 172 | 29561478 |
Drug abuse | 24.47 | 16.20 | 3 | 12874 | 79880 | 29481770 |
Cardiac failure chronic | 24.02 | 16.20 | 21 | 12856 | 6446 | 29555204 |
Hemiplegia | 23.67 | 16.20 | 21 | 12856 | 6573 | 29555077 |
Vasoplegia syndrome | 23.53 | 16.20 | 12 | 12865 | 1496 | 29560154 |
Implant site inflammation | 22.93 | 16.20 | 6 | 12871 | 106 | 29561544 |
Interstitial lung disease | 22.92 | 16.20 | 66 | 12811 | 57652 | 29503998 |
Cell death | 22.76 | 16.20 | 13 | 12864 | 2031 | 29559619 |
Oedema peripheral | 22.50 | 16.20 | 97 | 12780 | 103460 | 29458190 |
Ischaemic stroke | 22.30 | 16.20 | 31 | 12846 | 15946 | 29545704 |
Presyncope | 22.14 | 16.20 | 31 | 12846 | 16058 | 29545592 |
Post thrombotic syndrome | 21.81 | 16.20 | 6 | 12871 | 129 | 29561521 |
Renal artery restenosis | 21.42 | 16.20 | 4 | 12873 | 12 | 29561638 |
Bundle branch block right | 21.39 | 16.20 | 20 | 12857 | 6697 | 29554953 |
Laryngeal leukoplakia | 21.30 | 16.20 | 5 | 12872 | 55 | 29561595 |
Eosinophilia | 21.08 | 16.20 | 36 | 12841 | 22125 | 29539525 |
Hypoglycaemia | 20.88 | 16.20 | 57 | 12820 | 48289 | 29513361 |
Respiratory alkalosis | 20.84 | 16.20 | 11 | 12866 | 1472 | 29560178 |
Coma | 20.64 | 16.20 | 50 | 12827 | 39400 | 29522250 |
Agranulocytosis | 20.62 | 16.20 | 34 | 12843 | 20306 | 29541344 |
Retinal vein occlusion | 20.55 | 16.20 | 11 | 12866 | 1514 | 29560136 |
Cerebral haematoma | 20.22 | 16.20 | 16 | 12861 | 4280 | 29557370 |
Drug interaction | 20.21 | 16.20 | 151 | 12726 | 197234 | 29364416 |
Anti factor VIII antibody positive | 19.81 | 16.20 | 5 | 12872 | 76 | 29561574 |
Autoimmune enteropathy | 19.80 | 16.20 | 4 | 12873 | 20 | 29561630 |
Product monitoring error | 19.67 | 16.20 | 13 | 12864 | 2632 | 29559018 |
Torsade de pointes | 19.62 | 16.20 | 19 | 12858 | 6642 | 29555008 |
Hyperlactacidaemia | 19.52 | 16.20 | 13 | 12864 | 2665 | 29558985 |
Cholangiocarcinoma | 19.14 | 16.20 | 9 | 12868 | 941 | 29560709 |
Gallbladder enlargement | 19.13 | 16.20 | 9 | 12868 | 942 | 29560708 |
Electrolyte imbalance | 19.01 | 16.20 | 24 | 12853 | 11250 | 29550400 |
Platelet count decreased | 18.99 | 16.20 | 11 | 12866 | 104661 | 29456989 |
Splenomegaly | 18.89 | 16.20 | 26 | 12851 | 13253 | 29548397 |
Haematoma | 18.61 | 16.20 | 35 | 12842 | 23177 | 29538473 |
Bradyphrenia | 18.36 | 16.20 | 15 | 12862 | 4199 | 29557451 |
Schizophrenia | 17.99 | 16.20 | 18 | 12859 | 6547 | 29555103 |
Glycosylated haemoglobin abnormal | 17.94 | 16.20 | 5 | 12872 | 113 | 29561537 |
Traumatic haemothorax | 17.87 | 16.20 | 6 | 12871 | 257 | 29561393 |
Urethral cancer | 17.87 | 16.20 | 4 | 12873 | 35 | 29561615 |
Bundle branch block left | 17.36 | 16.20 | 16 | 12861 | 5261 | 29556389 |
Livedo reticularis | 17.34 | 16.20 | 11 | 12866 | 2077 | 29559573 |
Hypoglycaemic encephalopathy | 17.34 | 16.20 | 6 | 12871 | 282 | 29561368 |
Body mass index abnormal | 17.17 | 16.20 | 5 | 12872 | 133 | 29561517 |
Hypotension | 16.78 | 16.20 | 143 | 12734 | 194211 | 29367439 |
Basal ganglia haematoma | 16.65 | 16.20 | 4 | 12873 | 49 | 29561601 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute kidney injury | 490.55 | 14.27 | 763 | 26671 | 448477 | 64022821 |
Hyponatraemia | 265.52 | 14.27 | 321 | 27113 | 148018 | 64323280 |
General physical health deterioration | 210.38 | 14.27 | 339 | 27095 | 204086 | 64267212 |
Hyperkalaemia | 168.09 | 14.27 | 211 | 27223 | 100918 | 64370380 |
Lactic acidosis | 151.02 | 14.27 | 157 | 27277 | 61253 | 64410045 |
Pemphigoid | 113.36 | 14.27 | 70 | 27364 | 12916 | 64458382 |
Cholestasis | 110.79 | 14.27 | 115 | 27319 | 44757 | 64426541 |
Hypokalaemia | 107.64 | 14.27 | 189 | 27245 | 121714 | 64349584 |
Hypotension | 104.22 | 14.27 | 377 | 27057 | 380597 | 64090701 |
Drug ineffective | 99.97 | 14.27 | 127 | 27307 | 840120 | 63631178 |
Fall | 89.29 | 14.27 | 382 | 27052 | 416444 | 64054854 |
Cell death | 87.51 | 14.27 | 40 | 27394 | 4014 | 64467284 |
Hepatocellular injury | 85.83 | 14.27 | 101 | 27333 | 45134 | 64426164 |
Eosinophilia | 80.65 | 14.27 | 90 | 27344 | 37986 | 64433312 |
Completed suicide | 78.92 | 14.27 | 4 | 27430 | 224410 | 64246888 |
Death | 78.28 | 14.27 | 55 | 27379 | 482650 | 63988648 |
Vasoplegia syndrome | 78.20 | 14.27 | 33 | 27401 | 2734 | 64468564 |
Pallor | 72.59 | 14.27 | 86 | 27348 | 38695 | 64432603 |
Bradycardia | 69.98 | 14.27 | 155 | 27279 | 118064 | 64353234 |
Sprue-like enteropathy | 68.57 | 14.27 | 23 | 27411 | 1006 | 64470292 |
Pain | 67.38 | 14.27 | 82 | 27352 | 553429 | 63917869 |
Anaemia | 66.85 | 14.27 | 328 | 27106 | 378352 | 64092946 |
Ischaemic stroke | 65.59 | 14.27 | 71 | 27363 | 28964 | 64442334 |
Metabolic acidosis | 62.56 | 14.27 | 110 | 27324 | 70848 | 64400450 |
Labile hypertension | 60.94 | 14.27 | 18 | 27416 | 516 | 64470782 |
Hypertensive crisis | 60.50 | 14.27 | 55 | 27379 | 18193 | 64453105 |
Haematochezia | 59.95 | 14.27 | 104 | 27330 | 66269 | 64405029 |
Hepatic vein dilatation | 59.47 | 14.27 | 15 | 27419 | 233 | 64471065 |
Confusional state | 57.06 | 14.27 | 241 | 27193 | 260903 | 64210395 |
Electrocardiogram QT prolonged | 56.11 | 14.27 | 112 | 27322 | 79336 | 64391962 |
Liver palpable | 54.47 | 14.27 | 15 | 27419 | 332 | 64470966 |
Inappropriate antidiuretic hormone secretion | 52.98 | 14.27 | 56 | 27378 | 22233 | 64449065 |
Drug interaction | 52.43 | 14.27 | 297 | 27137 | 361786 | 64109512 |
Hyperlactacidaemia | 52.42 | 14.27 | 30 | 27404 | 4814 | 64466484 |
Nasopharyngitis | 52.29 | 14.27 | 10 | 27424 | 196063 | 64275235 |
Product dose omission issue | 51.79 | 14.27 | 10 | 27424 | 194737 | 64276561 |
Labelled drug-drug interaction medication error | 51.68 | 14.27 | 55 | 27379 | 22007 | 64449291 |
Atrial fibrillation | 50.64 | 14.27 | 174 | 27260 | 170915 | 64300383 |
Drug hypersensitivity | 50.50 | 14.27 | 19 | 27415 | 237796 | 64233502 |
Syncope | 49.91 | 14.27 | 164 | 27270 | 157471 | 64313827 |
Infusion related reaction | 49.29 | 14.27 | 6 | 27428 | 164461 | 64306837 |
Narrow anterior chamber angle | 49.28 | 14.27 | 12 | 27422 | 160 | 64471138 |
Product prescribing error | 48.32 | 14.27 | 67 | 27367 | 35202 | 64436096 |
Sinusitis | 47.16 | 14.27 | 4 | 27430 | 145924 | 64325374 |
Cerebral haematoma | 46.23 | 14.27 | 32 | 27402 | 7153 | 64464145 |
Anuria | 45.70 | 14.27 | 48 | 27386 | 18916 | 64452382 |
Swelling | 45.29 | 14.27 | 7 | 27427 | 160211 | 64311087 |
Ventricular enlargement | 44.22 | 14.27 | 14 | 27420 | 509 | 64470789 |
Inferior vena cava dilatation | 43.00 | 14.27 | 15 | 27419 | 739 | 64470559 |
Rash maculo-papular | 41.56 | 14.27 | 73 | 27361 | 46953 | 64424345 |
Presyncope | 41.26 | 14.27 | 62 | 27372 | 35027 | 64436271 |
Atrial enlargement | 41.02 | 14.27 | 14 | 27420 | 646 | 64470652 |
Oedema peripheral | 39.78 | 14.27 | 186 | 27248 | 210131 | 64261167 |
Creutzfeldt-Jakob disease | 38.69 | 14.27 | 10 | 27424 | 172 | 64471126 |
Rheumatoid arthritis | 38.61 | 14.27 | 11 | 27423 | 164283 | 64307015 |
Arthropathy | 37.28 | 14.27 | 4 | 27430 | 120963 | 64350335 |
Orthostatic hypotension | 36.79 | 14.27 | 69 | 27365 | 46669 | 64424629 |
Product monitoring error | 36.76 | 14.27 | 25 | 27409 | 5429 | 64465869 |
Renin increased | 36.63 | 14.27 | 10 | 27424 | 214 | 64471084 |
Lens dislocation | 36.55 | 14.27 | 9 | 27425 | 126 | 64471172 |
Supine hypertension | 36.14 | 14.27 | 11 | 27423 | 350 | 64470948 |
Haematoma | 36.06 | 14.27 | 68 | 27366 | 46182 | 64425116 |
Medication error | 35.94 | 14.27 | 71 | 27363 | 49895 | 64421403 |
Interstitial lung disease | 33.94 | 14.27 | 105 | 27329 | 97627 | 64373671 |
Vascular purpura | 33.62 | 14.27 | 18 | 27416 | 2538 | 64468760 |
Abdominal discomfort | 33.32 | 14.27 | 18 | 27416 | 182304 | 64288994 |
Treatment failure | 33.24 | 14.27 | 5 | 27429 | 116811 | 64354487 |
Therapeutic product effect decreased | 32.68 | 14.27 | 5 | 27429 | 115346 | 64355952 |
Alopecia | 32.32 | 14.27 | 15 | 27419 | 165675 | 64305623 |
Acute pulmonary oedema | 31.90 | 14.27 | 33 | 27401 | 12776 | 64458522 |
White blood cell count decreased | 31.24 | 14.27 | 14 | 27420 | 157823 | 64313475 |
Hypovolaemic shock | 30.28 | 14.27 | 29 | 27405 | 10237 | 64461061 |
Meningorrhagia | 30.14 | 14.27 | 9 | 27425 | 268 | 64471030 |
Toxic skin eruption | 30.03 | 14.27 | 39 | 27395 | 19245 | 64452053 |
Pancreatitis acute | 29.74 | 14.27 | 60 | 27374 | 42795 | 64428503 |
Overdose | 29.33 | 14.27 | 140 | 27294 | 159426 | 64311872 |
Hypomagnesaemia | 29.19 | 14.27 | 55 | 27379 | 37321 | 64433977 |
Dyspnoea at rest | 29.04 | 14.27 | 23 | 27411 | 6306 | 64464992 |
Helplessness | 28.70 | 14.27 | 9 | 27425 | 317 | 64470981 |
Altered state of consciousness | 28.64 | 14.27 | 55 | 27379 | 37847 | 64433451 |
Platelet count decreased | 28.60 | 14.27 | 18 | 27416 | 167693 | 64303605 |
Immune-mediated pancreatitis | 28.43 | 14.27 | 7 | 27427 | 98 | 64471200 |
Mesenteric artery thrombosis | 27.88 | 14.27 | 10 | 27424 | 535 | 64470763 |
Shock haemorrhagic | 27.78 | 14.27 | 35 | 27399 | 16756 | 64454542 |
Cardiac failure | 27.19 | 14.27 | 120 | 27314 | 132253 | 64339045 |
Renal failure | 26.86 | 14.27 | 150 | 27284 | 181538 | 64289760 |
Epileptic encephalopathy | 26.67 | 14.27 | 9 | 27425 | 401 | 64470897 |
Suicide attempt | 26.25 | 14.27 | 78 | 27356 | 70929 | 64400369 |
Retinal artery occlusion | 26.23 | 14.27 | 16 | 27418 | 2887 | 64468411 |
Hypocalcaemia | 26.10 | 14.27 | 56 | 27378 | 41697 | 64429601 |
Tongue oedema | 25.85 | 14.27 | 21 | 27413 | 5969 | 64465329 |
Coma | 25.79 | 14.27 | 89 | 27345 | 87526 | 64383772 |
Hallucination, gustatory | 25.53 | 14.27 | 6 | 27428 | 68 | 64471230 |
Asthma | 25.07 | 14.27 | 5 | 27429 | 95220 | 64376078 |
Nephroangiosclerosis | 24.85 | 14.27 | 8 | 27426 | 307 | 64470991 |
Oropharyngeal pain | 24.84 | 14.27 | 4 | 27430 | 88863 | 64382435 |
Bundle branch block right | 24.76 | 14.27 | 26 | 27408 | 10243 | 64461055 |
Coronary artery stenosis | 24.52 | 14.27 | 27 | 27407 | 11221 | 64460077 |
Tachycardia | 24.48 | 14.27 | 127 | 27307 | 149452 | 64321846 |
Walking disability | 24.24 | 14.27 | 13 | 27421 | 1838 | 64469460 |
Arthralgia | 23.82 | 14.27 | 102 | 27332 | 442158 | 64029140 |
Haematemesis | 23.80 | 14.27 | 58 | 27376 | 46941 | 64424357 |
Electrocardiogram abnormal | 23.75 | 14.27 | 29 | 27405 | 13452 | 64457846 |
Cardiac failure congestive | 23.70 | 14.27 | 13 | 27421 | 130567 | 64340731 |
Hypoglycaemia | 23.64 | 14.27 | 88 | 27346 | 89804 | 64381494 |
Pneumonia | 23.36 | 14.27 | 141 | 27293 | 559435 | 63911863 |
Radiation fibrosis | 23.19 | 14.27 | 5 | 27429 | 37 | 64471261 |
Disease progression | 23.08 | 14.27 | 16 | 27418 | 141664 | 64329634 |
Spontaneous haematoma | 22.69 | 14.27 | 11 | 27423 | 1260 | 64470038 |
Diabetic metabolic decompensation | 22.03 | 14.27 | 14 | 27420 | 2714 | 64468584 |
Cardiac failure chronic | 21.99 | 14.27 | 23 | 27411 | 9018 | 64462280 |
Pulmonary vein occlusion | 21.87 | 14.27 | 6 | 27428 | 131 | 64471167 |
Injection site pain | 21.85 | 14.27 | 10 | 27424 | 111398 | 64359900 |
Bundle branch block left | 21.72 | 14.27 | 24 | 27410 | 10010 | 64461288 |
Renal dysplasia | 21.51 | 14.27 | 4 | 27430 | 12 | 64471286 |
Renal artery restenosis | 21.51 | 14.27 | 4 | 27430 | 12 | 64471286 |
Abdominal compartment syndrome | 21.47 | 14.27 | 11 | 27423 | 1417 | 64469881 |
Laryngeal leukoplakia | 21.33 | 14.27 | 5 | 27429 | 56 | 64471242 |
Acute coronary syndrome | 21.12 | 14.27 | 33 | 27401 | 19277 | 64452021 |
Renal artery stenosis | 20.95 | 14.27 | 14 | 27420 | 2955 | 64468343 |
Mental status changes postoperative | 20.73 | 14.27 | 6 | 27428 | 160 | 64471138 |
Drug intolerance | 20.60 | 14.27 | 30 | 27404 | 187962 | 64283336 |
Dyspnoea | 20.34 | 14.27 | 423 | 27011 | 718251 | 63753047 |
Sopor | 19.95 | 14.27 | 41 | 27393 | 29620 | 64441678 |
Necrotising myositis | 19.86 | 14.27 | 9 | 27425 | 885 | 64470413 |
Anti factor VIII antibody positive | 19.80 | 14.27 | 5 | 27429 | 78 | 64471220 |
Mobility decreased | 19.69 | 14.27 | 6 | 27428 | 85834 | 64385464 |
Hospitalisation | 19.69 | 14.27 | 4 | 27430 | 75203 | 64396095 |
Intestinal villi atrophy | 19.58 | 14.27 | 7 | 27427 | 371 | 64470927 |
Confusion postoperative | 19.45 | 14.27 | 6 | 27428 | 200 | 64471098 |
Joint swelling | 19.36 | 14.27 | 39 | 27395 | 215343 | 64255955 |
Therapeutic product effect incomplete | 19.22 | 14.27 | 10 | 27424 | 103472 | 64367826 |
Angina pectoris | 19.07 | 14.27 | 52 | 27382 | 45029 | 64426269 |
Pseudophaeochromocytoma | 19.03 | 14.27 | 5 | 27429 | 92 | 64471206 |
Arthritis | 18.97 | 14.27 | 6 | 27428 | 83808 | 64387490 |
Implant site inflammation | 18.93 | 14.27 | 6 | 27428 | 219 | 64471079 |
Product use issue | 18.89 | 14.27 | 22 | 27412 | 151693 | 64319605 |
Adenocarcinoma metastatic | 18.78 | 14.27 | 5 | 27429 | 97 | 64471201 |
Wrong drug | 18.60 | 14.27 | 6 | 27428 | 232 | 64471066 |
Traumatic haematoma | 18.32 | 14.27 | 11 | 27423 | 1929 | 64469369 |
Atrioventricular block | 18.24 | 14.27 | 24 | 27410 | 11991 | 64459307 |
Agranulocytosis | 18.11 | 14.27 | 46 | 27388 | 38183 | 64433115 |
Renal artery arteriosclerosis | 17.86 | 14.27 | 4 | 27430 | 36 | 64471262 |
Bradyphrenia | 17.83 | 14.27 | 21 | 27413 | 9385 | 64461913 |
Autoimmune enteropathy | 17.57 | 14.27 | 4 | 27430 | 39 | 64471259 |
Renal cyst | 17.39 | 14.27 | 24 | 27410 | 12546 | 64458752 |
Frontotemporal dementia | 17.35 | 14.27 | 7 | 27427 | 517 | 64470781 |
Hypersensitivity | 17.29 | 14.27 | 36 | 27398 | 196416 | 64274882 |
Melaena | 17.18 | 14.27 | 56 | 27378 | 53492 | 64417806 |
Migraine | 17.12 | 14.27 | 3 | 27431 | 62674 | 64408624 |
Electrolyte imbalance | 17.11 | 14.27 | 35 | 27399 | 25208 | 64446090 |
Hemiplegia | 17.10 | 14.27 | 24 | 27410 | 12744 | 64458554 |
Glycosylated haemoglobin abnormal | 17.04 | 14.27 | 5 | 27429 | 140 | 64471158 |
Neuropathy peripheral | 16.96 | 14.27 | 15 | 27419 | 117510 | 64353788 |
Headache | 16.93 | 14.27 | 144 | 27290 | 529323 | 63941975 |
Rhonchi | 16.79 | 14.27 | 13 | 27421 | 3450 | 64467848 |
Retroperitoneal fibrosis | 16.73 | 14.27 | 7 | 27427 | 568 | 64470730 |
Convulsive threshold lowered | 16.71 | 14.27 | 8 | 27426 | 891 | 64470407 |
Urethral cancer | 16.66 | 14.27 | 4 | 27430 | 50 | 64471248 |
Amyotrophy | 16.54 | 14.27 | 7 | 27427 | 584 | 64470714 |
Arterial spasm | 16.49 | 14.27 | 5 | 27429 | 157 | 64471141 |
Nocturia | 16.48 | 14.27 | 22 | 27412 | 11143 | 64460155 |
Tongue neoplasm malignant stage unspecified | 16.45 | 14.27 | 8 | 27426 | 922 | 64470376 |
Myopathy | 16.34 | 14.27 | 28 | 27406 | 17652 | 64453646 |
Pneumocystis jirovecii infection | 16.34 | 14.27 | 11 | 27423 | 2350 | 64468948 |
Musculoskeletal stiffness | 16.29 | 14.27 | 17 | 27417 | 123189 | 64348109 |
Hyperglycaemia | 16.29 | 14.27 | 60 | 27374 | 60908 | 64410390 |
Discomfort | 16.27 | 14.27 | 7 | 27427 | 80871 | 64390427 |
Systemic infection | 16.27 | 14.27 | 14 | 27420 | 4307 | 64466991 |
Basal ganglia haematoma | 16.18 | 14.27 | 4 | 27430 | 57 | 64471241 |
Gallbladder enlargement | 16.12 | 14.27 | 9 | 27425 | 1377 | 64469921 |
Livedo reticularis | 16.04 | 14.27 | 13 | 27421 | 3684 | 64467614 |
Intermittent claudication | 15.98 | 14.27 | 12 | 27422 | 3042 | 64468256 |
Fluid retention | 15.96 | 14.27 | 3 | 27431 | 59603 | 64411695 |
Angioedema | 15.81 | 14.27 | 60 | 27374 | 61761 | 64409537 |
Traumatic haemothorax | 15.55 | 14.27 | 6 | 27428 | 394 | 64470904 |
Respiratory alkalosis | 15.44 | 14.27 | 13 | 27421 | 3884 | 64467414 |
Prerenal failure | 15.41 | 14.27 | 12 | 27422 | 3210 | 64468088 |
Torsade de pointes | 15.39 | 14.27 | 27 | 27407 | 17336 | 64453962 |
Acute generalised exanthematous pustulosis | 15.34 | 14.27 | 24 | 27410 | 14034 | 64457264 |
Intracranial mass | 15.30 | 14.27 | 10 | 27424 | 2033 | 64469265 |
Claudication of jaw muscles | 15.15 | 14.27 | 4 | 27430 | 75 | 64471223 |
Delusional disorder, unspecified type | 15.09 | 14.27 | 7 | 27427 | 726 | 64470572 |
Oxygen saturation decreased | 15.08 | 14.27 | 14 | 27420 | 107162 | 64364136 |
Body mass index abnormal | 15.01 | 14.27 | 5 | 27429 | 214 | 64471084 |
C-reactive protein decreased | 14.98 | 14.27 | 10 | 27424 | 2106 | 64469192 |
Miosis | 14.97 | 14.27 | 23 | 27411 | 13243 | 64458055 |
Depression | 14.97 | 14.27 | 35 | 27399 | 183256 | 64288042 |
Weight increased | 14.94 | 14.27 | 44 | 27390 | 213304 | 64257994 |
Infected lymphocele | 14.85 | 14.27 | 5 | 27429 | 221 | 64471077 |
Hallucination, olfactory | 14.80 | 14.27 | 6 | 27428 | 449 | 64470849 |
Hallucination, visual | 14.79 | 14.27 | 35 | 27399 | 27799 | 64443499 |
Poisoning deliberate | 14.72 | 14.27 | 23 | 27411 | 13435 | 64457863 |
Splenic rupture | 14.55 | 14.27 | 10 | 27424 | 2209 | 64469089 |
Prothrombin time shortened | 14.48 | 14.27 | 11 | 27423 | 2838 | 64468460 |
White blood cell count increased | 14.46 | 14.27 | 5 | 27429 | 66009 | 64405289 |
Seizure | 14.33 | 14.27 | 31 | 27403 | 166861 | 64304437 |
Crowned dens syndrome | 14.32 | 14.27 | 3 | 27431 | 19 | 64471279 |
None
Source | Code | Description |
---|---|---|
ATC | C08CA13 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
ATC | C09BB02 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09DB08 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002121 | Calcium Channel Blockers |
MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.96 | Basic |
pKa2 | 2.09 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Voltage-gated L-type calcium channel | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
ID | Source |
---|---|
D01849 | KEGG_DRUG |
132866-11-6 | SECONDARY_CAS_RN |
C0526399 | UMLSCUI |
CHEBI:31771 | CHEBI |
CHEMBL250270 | ChEMBL_ID |
CHEMBL2106419 | ChEMBL_ID |
DB00528 | DRUGBANK_ID |
C060343 | MESH_SUPPLEMENTAL_RECORD_UI |
6971 | INN_ID |
V7XTJ4R0BH | UNII |
65866 | PUBCHEM_CID |
135056 | RXNORM |
007361 | NDDF |
007362 | NDDF |
356862006 | SNOMEDCT_US |
395768003 | SNOMEDCT_US |
395986007 | SNOMEDCT_US |
None