lercanidipine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| calcium channel blockers, nifedipine derivatives | 4157 | 100427-26-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 10 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hyponatraemia | 354.81 | 16.26 | 297 | 17130 | 101035 | 46567600 |
| Acute kidney injury | 330.64 | 16.26 | 422 | 17005 | 235433 | 46433202 |
| General physical health deterioration | 161.26 | 16.26 | 207 | 17220 | 115562 | 46553073 |
| Lactic acidosis | 138.61 | 16.26 | 109 | 17318 | 33800 | 46634835 |
| Hyperkalaemia | 137.85 | 16.26 | 129 | 17298 | 50580 | 46618055 |
| Hypotension | 120.71 | 16.26 | 267 | 17160 | 232322 | 46436313 |
| Fall | 118.19 | 16.26 | 328 | 17099 | 328769 | 46339866 |
| Confusional state | 112 | 16.26 | 208 | 17219 | 159684 | 46508951 |
| Hypokalaemia | 111.02 | 16.26 | 150 | 17277 | 87874 | 46580761 |
| Drug interaction | 90.80 | 16.26 | 220 | 17207 | 202874 | 46465761 |
| Cholestasis | 88.01 | 16.26 | 76 | 17351 | 26817 | 46641818 |
| Anaemia | 78.23 | 16.26 | 241 | 17186 | 255538 | 46413097 |
| Hepatocellular injury | 76.16 | 16.26 | 73 | 17354 | 29449 | 46639186 |
| Pemphigoid | 73.76 | 16.26 | 38 | 17389 | 5653 | 46662982 |
| Pallor | 72.84 | 16.26 | 64 | 17363 | 23102 | 46645533 |
| Rheumatoid arthritis | 70.44 | 16.26 | 5 | 17422 | 240210 | 46428425 |
| Pain | 67.61 | 16.26 | 48 | 17379 | 476900 | 46191735 |
| Labile hypertension | 64.15 | 16.26 | 18 | 17409 | 490 | 46668145 |
| Drug ineffective | 59.94 | 16.26 | 101 | 17326 | 677737 | 45990898 |
| Bradycardia | 59.03 | 16.26 | 96 | 17331 | 66202 | 46602433 |
| Cell death | 56.93 | 16.26 | 24 | 17403 | 2264 | 46666371 |
| Hypertension | 56.25 | 16.26 | 181 | 17246 | 196175 | 46472460 |
| Atrial fibrillation | 53.62 | 16.26 | 119 | 17308 | 103471 | 46565164 |
| Drug hypersensitivity | 52.89 | 16.26 | 13 | 17414 | 243812 | 46424823 |
| Orthostatic hypotension | 52.59 | 16.26 | 55 | 17372 | 24603 | 46644032 |
| Death | 51.22 | 16.26 | 31 | 17396 | 335517 | 46333118 |
| Hypertensive crisis | 49.72 | 16.26 | 41 | 17386 | 13574 | 46655061 |
| Vasoplegia syndrome | 46.84 | 16.26 | 17 | 17410 | 1075 | 46667560 |
| Eosinophilia | 43.02 | 16.26 | 44 | 17383 | 19173 | 46649462 |
| Sopor | 41.87 | 16.26 | 44 | 17383 | 19784 | 46648851 |
| Myopathy | 41.64 | 16.26 | 31 | 17396 | 8850 | 46659785 |
| Toxic skin eruption | 40.50 | 16.26 | 35 | 17392 | 12352 | 46656283 |
| Poisoning deliberate | 40.17 | 16.26 | 29 | 17398 | 7897 | 46660738 |
| Anuria | 38.80 | 16.26 | 33 | 17394 | 11398 | 46657237 |
| Epileptic encephalopathy | 36.57 | 16.26 | 10 | 17417 | 247 | 46668388 |
| Product dose omission issue | 36.49 | 16.26 | 9 | 17418 | 168511 | 46500124 |
| Medication error | 36.38 | 16.26 | 51 | 17376 | 30860 | 46637775 |
| Renin increased | 35.92 | 16.26 | 9 | 17418 | 156 | 46668479 |
| Electrocardiogram QT prolonged | 34.86 | 16.26 | 66 | 17361 | 51259 | 46617376 |
| Sinusitis | 34.52 | 16.26 | 4 | 17423 | 129764 | 46538871 |
| Immune-mediated pancreatitis | 33.35 | 16.26 | 7 | 17420 | 52 | 46668583 |
| Rhabdomyolysis | 32.39 | 16.26 | 57 | 17370 | 41852 | 46626783 |
| Cardiac failure | 31.82 | 16.26 | 83 | 17344 | 79865 | 46588770 |
| Product prescribing error | 31.26 | 16.26 | 38 | 17389 | 20009 | 46648626 |
| Inappropriate antidiuretic hormone secretion | 31.04 | 16.26 | 32 | 17395 | 14070 | 46654565 |
| Helplessness | 28.68 | 16.26 | 8 | 17419 | 213 | 46668422 |
| Labelled drug-drug interaction medication error | 28.40 | 16.26 | 25 | 17402 | 9036 | 46659599 |
| Ischaemic stroke | 28.21 | 16.26 | 33 | 17394 | 16689 | 46651946 |
| Nasopharyngitis | 26.75 | 16.26 | 12 | 17415 | 153986 | 46514649 |
| Spontaneous haematoma | 26.41 | 16.26 | 10 | 17417 | 712 | 46667923 |
| Walking disability | 26.32 | 16.26 | 12 | 17415 | 1366 | 46667269 |
| Renal artery stenosis | 26.27 | 16.26 | 13 | 17414 | 1775 | 46666860 |
| Cerebral haematoma | 26.09 | 16.26 | 16 | 17411 | 3323 | 46665312 |
| Hallucination, gustatory | 25.92 | 16.26 | 6 | 17421 | 73 | 46668562 |
| Traumatic haematoma | 25.81 | 16.26 | 12 | 17415 | 1428 | 46667207 |
| Hyperglycaemic hyperosmolar nonketotic syndrome | 25.54 | 16.26 | 9 | 17418 | 522 | 46668113 |
| Necrotising myositis | 25.37 | 16.26 | 8 | 17419 | 328 | 46668307 |
| Acute pulmonary oedema | 25.19 | 16.26 | 22 | 17405 | 7869 | 46660766 |
| Exposure during pregnancy | 24.98 | 16.26 | 5 | 17422 | 108207 | 46560428 |
| Wrong product administered | 24.94 | 16.26 | 19 | 17408 | 5611 | 46663024 |
| Treatment failure | 24.43 | 16.26 | 3 | 17424 | 93084 | 46575551 |
| Mental status changes postoperative | 24.36 | 16.26 | 7 | 17420 | 208 | 46668427 |
| Gamma-glutamyltransferase increased | 24.31 | 16.26 | 43 | 17384 | 31697 | 46636938 |
| Tachycardia | 24.20 | 16.26 | 87 | 17340 | 99535 | 46569100 |
| Arrhythmia | 23.89 | 16.26 | 45 | 17382 | 34796 | 46633839 |
| Confusion postoperative | 23.86 | 16.26 | 7 | 17420 | 224 | 46668411 |
| Altered state of consciousness | 23.80 | 16.26 | 36 | 17391 | 23312 | 46645323 |
| Prothrombin time shortened | 23.53 | 16.26 | 12 | 17415 | 1747 | 46666888 |
| Radiation fibrosis | 23.50 | 16.26 | 5 | 17422 | 40 | 46668595 |
| Tongue oedema | 23.43 | 16.26 | 16 | 17411 | 3990 | 46664645 |
| Sprue-like enteropathy | 23.20 | 16.26 | 8 | 17419 | 435 | 46668200 |
| Abdominal discomfort | 22.96 | 16.26 | 14 | 17413 | 151151 | 46517484 |
| Arthralgia | 22.48 | 16.26 | 66 | 17361 | 364537 | 46304098 |
| White blood cell count decreased | 22.40 | 16.26 | 7 | 17420 | 112224 | 46556411 |
| Postural tremor | 22.18 | 16.26 | 6 | 17421 | 142 | 46668493 |
| Renal failure | 21.74 | 16.26 | 92 | 17335 | 113502 | 46555133 |
| Haematochezia | 21.58 | 16.26 | 45 | 17382 | 37448 | 46631187 |
| Retroperitoneal fibrosis | 21.14 | 16.26 | 7 | 17420 | 336 | 46668299 |
| Adenocarcinoma metastatic | 21.02 | 16.26 | 5 | 17422 | 69 | 46668566 |
| Ultrasound liver abnormal | 20.95 | 16.26 | 4 | 17423 | 17 | 46668618 |
| Rhonchi | 20.93 | 16.26 | 12 | 17415 | 2203 | 46666432 |
| Arterial spasm | 20.89 | 16.26 | 5 | 17422 | 71 | 46668564 |
| Disorientation | 20.89 | 16.26 | 44 | 17383 | 36874 | 46631761 |
| Infusion related reaction | 20.77 | 16.26 | 6 | 17421 | 101202 | 46567433 |
| Pseudophaeochromocytoma | 20.51 | 16.26 | 5 | 17422 | 77 | 46668558 |
| Degenerative mitral valve disease | 20.25 | 16.26 | 4 | 17423 | 21 | 46668614 |
| Degenerative aortic valve disease | 20.10 | 16.26 | 4 | 17423 | 22 | 46668613 |
| Shock haemorrhagic | 19.76 | 16.26 | 20 | 17407 | 8604 | 46660031 |
| Coma | 19.65 | 16.26 | 57 | 17370 | 58292 | 46610343 |
| Joint swelling | 19.42 | 16.26 | 20 | 17407 | 166053 | 46502582 |
| Hallucination, olfactory | 19.42 | 16.26 | 6 | 17421 | 230 | 46668405 |
| Haematoma | 19.22 | 16.26 | 39 | 17388 | 31833 | 46636802 |
| Injection site pain | 19.15 | 16.26 | 8 | 17419 | 107144 | 46561491 |
| Cerebral salt-wasting syndrome | 19.15 | 16.26 | 4 | 17423 | 29 | 46668606 |
| Oedema peripheral | 18.96 | 16.26 | 113 | 17314 | 159593 | 46509042 |
| Hypocalcaemia | 18.87 | 16.26 | 35 | 17392 | 26750 | 46641885 |
| Hallucination, visual | 18.85 | 16.26 | 28 | 17399 | 17845 | 46650790 |
| Frontotemporal dementia | 18.82 | 16.26 | 6 | 17421 | 255 | 46668380 |
| Blood creatinine increased | 18.79 | 16.26 | 67 | 17360 | 76336 | 46592299 |
| Swelling | 18.26 | 16.26 | 12 | 17415 | 124499 | 46544136 |
| Miosis | 18.18 | 16.26 | 17 | 17410 | 6640 | 46661995 |
| Polyneuropathy | 18.03 | 16.26 | 22 | 17405 | 11622 | 46657013 |
| Status epilepticus | 17.85 | 16.26 | 24 | 17403 | 13955 | 46654680 |
| Asthma | 17.76 | 16.26 | 6 | 17421 | 91536 | 46577099 |
| Purpura | 17.38 | 16.26 | 20 | 17407 | 9938 | 46658697 |
| Depression | 17.19 | 16.26 | 23 | 17404 | 170081 | 46498554 |
| Haematemesis | 17.08 | 16.26 | 35 | 17392 | 28771 | 46639864 |
| Polyuria | 17.06 | 16.26 | 17 | 17410 | 7178 | 46661457 |
| Arthritis | 16.97 | 16.26 | 4 | 17423 | 77312 | 46591323 |
| Tinnitus | 16.85 | 16.26 | 34 | 17393 | 27639 | 46640996 |
| Somnolence | 16.85 | 16.26 | 108 | 17319 | 156413 | 46512222 |
| Intestinal villi atrophy | 16.84 | 16.26 | 5 | 17422 | 167 | 46668468 |
| Convulsive threshold lowered | 16.74 | 16.26 | 6 | 17421 | 366 | 46668269 |
| Pulmonary haematoma | 16.57 | 16.26 | 4 | 17423 | 59 | 46668576 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Acute kidney injury | 228.25 | 14.29 | 449 | 14351 | 273393 | 29664285 |
| Lactic acidosis | 102.60 | 14.29 | 100 | 14700 | 31113 | 29906565 |
| Hyperkalaemia | 75.84 | 14.29 | 125 | 14675 | 65885 | 29871793 |
| General physical health deterioration | 64.16 | 14.29 | 148 | 14652 | 99796 | 29837882 |
| Death | 61.51 | 14.29 | 52 | 14748 | 357231 | 29580447 |
| Metabolic acidosis | 57.21 | 14.29 | 81 | 14719 | 37380 | 29900298 |
| Hyponatraemia | 44.71 | 14.29 | 101 | 14699 | 67101 | 29870577 |
| Drug ineffective | 39.87 | 14.29 | 67 | 14733 | 340320 | 29597358 |
| Hypertensive crisis | 37.68 | 14.29 | 32 | 14768 | 8325 | 29929353 |
| Cerebral haematoma | 37.67 | 14.29 | 25 | 14775 | 4489 | 29933189 |
| Pemphigoid | 36.37 | 14.29 | 30 | 14770 | 7498 | 29930180 |
| Vascular purpura | 35.99 | 14.29 | 17 | 14783 | 1580 | 29936098 |
| Nephroangiosclerosis | 35.98 | 14.29 | 10 | 14790 | 196 | 29937482 |
| Hypoglycaemia | 35.44 | 14.29 | 78 | 14722 | 50903 | 29886775 |
| Syncope | 35.28 | 14.29 | 107 | 14693 | 84796 | 29852882 |
| Drug interaction | 34.84 | 14.29 | 192 | 14608 | 199376 | 29738302 |
| Supine hypertension | 33.79 | 14.29 | 10 | 14790 | 247 | 29937431 |
| Hemiplegia | 33.13 | 14.29 | 27 | 14773 | 6634 | 29931044 |
| Completed suicide | 32.80 | 14.29 | 5 | 14795 | 99487 | 29838191 |
| Ischaemic stroke | 32.25 | 14.29 | 40 | 14760 | 16235 | 29921443 |
| Retinal artery occlusion | 32.14 | 14.29 | 16 | 14784 | 1668 | 29936010 |
| Haematoma | 29.69 | 14.29 | 47 | 14753 | 23906 | 29913772 |
| Bradycardia | 29.51 | 14.29 | 85 | 14715 | 65441 | 29872237 |
| Hypokalaemia | 28.55 | 14.29 | 71 | 14729 | 50121 | 29887557 |
| Orthostatic hypotension | 28.28 | 14.29 | 46 | 14754 | 23933 | 29913745 |
| Pain | 27.36 | 14.29 | 27 | 14773 | 172614 | 29765064 |
| Drug abuse | 27.33 | 14.29 | 4 | 14796 | 82068 | 29855610 |
| Coma | 27.11 | 14.29 | 61 | 14739 | 40388 | 29897290 |
| Cholestasis | 26.94 | 14.29 | 46 | 14754 | 24904 | 29912774 |
| Sprue-like enteropathy | 26.82 | 14.29 | 9 | 14791 | 338 | 29937340 |
| Inappropriate antidiuretic hormone secretion | 25.78 | 14.29 | 30 | 14770 | 11392 | 29926286 |
| Abdominal compartment syndrome | 24.96 | 14.29 | 11 | 14789 | 870 | 29936808 |
| Hepatocellular injury | 24.96 | 14.29 | 45 | 14755 | 25426 | 29912252 |
| Wrong drug | 24.72 | 14.29 | 6 | 14794 | 67 | 29937611 |
| Angioedema | 24.33 | 14.29 | 53 | 14747 | 34331 | 29903347 |
| Platelet count decreased | 24.32 | 14.29 | 11 | 14789 | 106118 | 29831560 |
| Vasoplegia syndrome | 24.03 | 14.29 | 12 | 14788 | 1259 | 29936419 |
| Electrocardiogram QT prolonged | 23.96 | 14.29 | 54 | 14746 | 35781 | 29901897 |
| Renal artery arteriosclerosis | 23.80 | 14.29 | 5 | 14795 | 27 | 29937651 |
| Mesenteric vein thrombosis | 23.16 | 14.29 | 9 | 14791 | 517 | 29937161 |
| Hyperlactacidaemia | 23.12 | 14.29 | 15 | 14785 | 2591 | 29935087 |
| Hypomagnesaemia | 22.57 | 14.29 | 34 | 14766 | 16564 | 29921114 |
| Narrow anterior chamber angle | 22.06 | 14.29 | 4 | 14796 | 8 | 29937670 |
| Bundle branch block right | 22.06 | 14.29 | 22 | 14778 | 7020 | 29930658 |
| Torsade de pointes | 21.68 | 14.29 | 22 | 14778 | 7168 | 29930510 |
| Renal artery restenosis | 20.91 | 14.29 | 4 | 14796 | 12 | 29937666 |
| Mesenteric artery thrombosis | 20.80 | 14.29 | 8 | 14792 | 447 | 29937231 |
| Laryngeal leukoplakia | 20.67 | 14.29 | 5 | 14795 | 55 | 29937623 |
| Hypertension | 20.61 | 14.29 | 116 | 14684 | 121238 | 29816440 |
| Presyncope | 20.58 | 14.29 | 32 | 14768 | 16024 | 29921654 |
| White blood cell count decreased | 20.35 | 14.29 | 8 | 14792 | 83939 | 29853739 |
| Respiratory alkalosis | 20.17 | 14.29 | 11 | 14789 | 1383 | 29936295 |
| Pancreatitis acute | 19.79 | 14.29 | 41 | 14759 | 25654 | 29912024 |
| Interstitial lung disease | 19.71 | 14.29 | 70 | 14730 | 60127 | 29877551 |
| Lens dislocation | 19.64 | 14.29 | 4 | 14796 | 18 | 29937660 |
| Bundle branch block left | 19.61 | 14.29 | 18 | 14782 | 5186 | 29932492 |
| Acute pulmonary oedema | 19.11 | 14.29 | 21 | 14779 | 7494 | 29930184 |
| Crystal urine | 18.94 | 14.29 | 5 | 14795 | 80 | 29937598 |
| Confusional state | 18.53 | 14.29 | 122 | 14678 | 134712 | 29802966 |
| Autoimmune enteropathy | 18.41 | 14.29 | 4 | 14796 | 26 | 29937652 |
| Anti factor VIII antibody positive | 18.09 | 14.29 | 5 | 14795 | 96 | 29937582 |
| Urethral cancer | 17.91 | 14.29 | 4 | 14796 | 30 | 29937648 |
| Traumatic haemothorax | 17.86 | 14.29 | 6 | 14794 | 226 | 29937452 |
| Cholangiocarcinoma | 17.80 | 14.29 | 9 | 14791 | 970 | 29936708 |
| Pneumocystis jirovecii infection | 17.78 | 14.29 | 10 | 14790 | 1335 | 29936343 |
| Rash maculo-papular | 17.77 | 14.29 | 39 | 14761 | 25379 | 29912299 |
| Intermittent claudication | 17.74 | 14.29 | 12 | 14788 | 2222 | 29935456 |
| Melaena | 17.51 | 14.29 | 45 | 14755 | 32392 | 29905286 |
| Cardiac failure congestive | 17.46 | 14.29 | 10 | 14790 | 84397 | 29853281 |
| Cell death | 17.37 | 14.29 | 12 | 14788 | 2299 | 29935379 |
| Cutaneous vasculitis | 16.75 | 14.29 | 13 | 14787 | 2978 | 29934700 |
| Renal failure | 16.71 | 14.29 | 115 | 14685 | 128851 | 29808827 |
| Pneumonia | 16.71 | 14.29 | 97 | 14703 | 334209 | 29603469 |
| Post thrombotic syndrome | 16.20 | 14.29 | 5 | 14795 | 143 | 29937535 |
| Shock haemorrhagic | 16.04 | 14.29 | 22 | 14778 | 9843 | 29927835 |
| Disease progression | 15.77 | 14.29 | 10 | 14790 | 79864 | 29857814 |
| Duodenal ulcer perforation | 15.66 | 14.29 | 10 | 14790 | 1682 | 29935996 |
| Livedo reticularis | 15.53 | 14.29 | 11 | 14789 | 2193 | 29935485 |
| Basal ganglia haematoma | 15.52 | 14.29 | 4 | 14796 | 58 | 29937620 |
| Cerebral haemorrhage | 15.12 | 14.29 | 43 | 14757 | 32844 | 29904834 |
| Oedema peripheral | 14.68 | 14.29 | 96 | 14704 | 105736 | 29831942 |
| Acute coronary syndrome | 14.61 | 14.29 | 25 | 14775 | 13548 | 29924130 |
| Vitamin B12 decreased | 14.46 | 14.29 | 8 | 14792 | 1034 | 29936644 |
| Eosinophilia | 14.37 | 14.29 | 33 | 14767 | 22127 | 29915551 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C08CA13 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
| ATC | C09BB02 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
| ATC | C09DB08 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.96 | Basic |
| pKa2 | 2.09 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Voltage-gated L-type calcium channel | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D01849 | KEGG_DRUG |
| 132866-11-6 | SECONDARY_CAS_RN |
| C0526399 | UMLSCUI |
| CHEBI:135930 | CHEBI |
| CHEMBL250270 | ChEMBL_ID |
| CHEMBL2106419 | ChEMBL_ID |
| DB00528 | DRUGBANK_ID |
| C060343 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6971 | INN_ID |
| V7XTJ4R0BH | UNII |
| 65866 | PUBCHEM_CID |
| 135056 | RXNORM |
| 007361 | NDDF |
| 007362 | NDDF |
| 356862006 | SNOMEDCT_US |
| 395768003 | SNOMEDCT_US |
| 395986007 | SNOMEDCT_US |
Pharmaceutical products:
None