lercanidipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
calcium channel blockers, nifedipine derivatives	4157	100427-26-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: lercanidipine hydrochloride lercanidipine masnidipine zanidip lercanidipine HCl	Molecular weight: 611.74 Formula: C36H41N3O6 CLOGP: 8 LIPINSKI: 2 HAC: 9 HDO: 1 TPSA: 111.01 ALOGS: -6.59 ROTB: 14

Molecule

Description

Molfile Inchi Smiles

Synonyms:

lercanidipine hydrochloride
lercanidipine
masnidipine
zanidip
lercanidipine HCl

Molecular weight: 611.74
Formula: C36H41N3O6
CLOGP: 8
LIPINSKI: 2
HAC: 9
HDO: 1
TPSA: 111.01
ALOGS: -6.59
ROTB: 14

Drug dosage:

Dose	Unit	Route
10	mg	O

ADMET properties:

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Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ
BA (Bioavailability)	10 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	0.01 mg/mL	Bocci G, Oprea TI, Benet LZ

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Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	455.75	16.86	464	17847	262951	63207760
Hyponatraemia	376.42	16.86	288	18023	111612	63359099
General physical health deterioration	169.59	16.86	247	18064	201155	63269556
Hyperkalaemia	163.48	16.86	131	18180	54072	63416639
Lactic acidosis	133.82	16.86	101	18210	38186	63432525
Hypokalaemia	130.23	16.86	155	18156	103649	63367062
Fall	122.82	16.86	316	17995	392018	63078693
Pemphigoid	119.84	16.86	53	18258	7291	63463420
Hypotension	119.80	16.86	251	18060	272353	63198358
Hypertensive crisis	114.41	16.86	65	18246	15221	63455490

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	254.24	15.51	467	14868	304521	34637075
General physical health deterioration	106.77	15.51	197	15138	128072	34813524
Lactic acidosis	86.97	15.51	91	15244	34681	34906915
Hyperkalaemia	78.08	15.51	122	15213	69267	34872329
Pemphigoid	62.74	15.51	42	15293	8624	34932972
Death	62.60	15.51	50	15285	397999	34543597
Hepatic vein dilatation	60.01	15.51	15	15320	217	34941379
Syncope	59.72	15.51	127	15208	91324	34850272
Inappropriate antidiuretic hormone secretion	58.68	15.51	47	15288	12706	34928890
Liver palpable	56.38	15.51	15	15320	281	34941315

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	633.97	13.88	909	31634	518495	79193350
Hyponatraemia	326.47	13.88	382	32161	177466	79534379
General physical health deterioration	265.19	13.88	433	32110	274805	79437040
Hyperkalaemia	213.47	13.88	248	32295	114150	79597695
Lactic acidosis	190.62	13.88	186	32357	70173	79641672
Pemphigoid	164.47	13.88	93	32450	15222	79696623
Hypokalaemia	125.59	13.88	217	32326	143823	79568022
Hypotension	118.03	13.88	421	32122	439896	79271949
Product prescribing error	114.88	13.88	115	32428	44698	79667147
Drug ineffective	113.07	13.88	167	32376	1080746	78631099

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C08CA13	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives
ATC	C09BB02	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers
ATC	C09DB08	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D049990	Membrane Transport Modulators

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.96	Basic
pKa2	2.09	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Voltage-gated L-type calcium channel	Ion channel	Q01668 Q13936	CAC1D_HUMAN CAC1C_HUMAN	BLOCKER				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

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External reference:

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ID	Source
007361	NDDF
007362	NDDF
132866-11-6	SECONDARY_CAS_RN
135056	RXNORM
356862006	SNOMEDCT_US
395768003	SNOMEDCT_US
395986007	SNOMEDCT_US
65866	PUBCHEM_CID
6971	INN_ID
C0526399	UMLSCUI

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Pharmaceutical products:

None