lercanidipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
calcium channel blockers, nifedipine derivatives	4157	100427-26-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: lercanidipine hydrochloride lercanidipine masnidipine zanidip lercanidipine HCl	Molecular weight: 611.74 Formula: C36H41N3O6 CLOGP: 8 LIPINSKI: 2 HAC: 9 HDO: 1 TPSA: 111.01 ALOGS: -6.59 ROTB: 14

Molecule

Description

Molfile Inchi Smiles

Synonyms:

lercanidipine hydrochloride
lercanidipine
masnidipine
zanidip
lercanidipine HCl

Molecular weight: 611.74
Formula: C36H41N3O6
CLOGP: 8
LIPINSKI: 2
HAC: 9
HDO: 1
TPSA: 111.01
ALOGS: -6.59
ROTB: 14

Drug dosage:

Dose	Unit	Route
10	mg	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	10 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	364.24	17.13	395	15030	227663	50362036
Hyponatraemia	282.83	17.13	234	15191	95905	50493794
General physical health deterioration	149.72	17.13	200	15225	142234	50447465
Hyperkalaemia	128.68	17.13	111	15314	47978	50541721
Hypotension	121.19	17.13	239	15186	235230	50354469
Fall	116.01	17.13	290	15135	334642	50255057
Lactic acidosis	105.85	17.13	85	15340	33270	50556429
Hypokalaemia	105.54	17.13	132	15293	87860	50501839
Cholestasis	105.48	17.13	76	15349	25325	50564374
Anaemia	80.39	17.13	212	15213	252244	50337455
Pallor	79.78	17.13	62	15363	23137	50566562
Hepatocellular injury	75.74	17.13	63	15362	25884	50563815
Eosinophilia	75.58	17.13	55	15370	18597	50571102
Cell death	73.29	17.13	27	15398	2188	50587511
Drug ineffective	71.87	17.13	87	15338	819246	49770453
Pemphigoid	70.69	17.13	35	15390	5872	50583827
Labile hypertension	69.12	17.13	18	15407	453	50589246
Confusional state	68.38	17.13	165	15260	185763	50403936
Vasoplegia syndrome	65.97	17.13	21	15404	1093	50588606
Atrial fibrillation	65.64	17.13	114	15311	101631	50488068
Pain	60.21	17.13	53	15372	578850	50010849
Product prescribing error	57.27	17.13	49	15376	20912	50568787
Labelled drug-drug interaction medication error	56.87	17.13	37	15388	10440	50579259
Bradycardia	53.54	17.13	81	15344	64345	50525354
Ischaemic stroke	53.48	17.13	42	15383	15906	50573793
Drug interaction	51.07	17.13	155	15270	199466	50390233
Hypertensive crisis	47.06	17.13	36	15389	13118	50576581
Drug hypersensitivity	46.31	17.13	10	15415	251000	50338699
Death	45.78	17.13	21	15404	325358	50264341
Abdominal discomfort	45.31	17.13	8	15417	231633	50358066
Sprue-like enteropathy	44.38	17.13	13	15412	510	50589189
Rheumatoid arthritis	44.28	17.13	5	15420	202545	50387154
Creutzfeldt-Jakob disease	44.26	17.13	10	15415	135	50589564
Sopor	41.59	17.13	40	15385	19839	50569860
Infusion related reaction	40.22	17.13	3	15422	169554	50420145
Hyperlactacidaemia	40.16	17.13	18	15407	2415	50587284
Medication error	39.81	17.13	52	15373	36052	50553647
Swelling	39.14	17.13	7	15418	200865	50388834
Anuria	38.53	17.13	30	15395	11214	50578485
Toxic skin eruption	38.52	17.13	30	15395	11221	50578478
Renin increased	38.07	17.13	9	15416	150	50589549
Haematemesis	35.45	17.13	43	15382	27682	50562017
Sinusitis	35.35	17.13	5	15420	170553	50419146
Tachycardia	34.97	17.13	87	15338	99676	50490023
Product dose omission issue	34.55	17.13	7	15418	183831	50405868
Immune-mediated pancreatitis	34.54	17.13	7	15418	54	50589645
Arthropathy	34.24	17.13	4	15421	157902	50431797
Orthostatic hypotension	33.34	17.13	43	15382	29438	50560261
Epileptic encephalopathy	33.14	17.13	9	15416	267	50589432
Haematochezia	32.91	17.13	50	15375	39832	50549867
Electrocardiogram QT prolonged	31.95	17.13	57	15368	51829	50537870
Joint swelling	31.24	17.13	18	15407	245268	50344431
Alopecia	31.18	17.13	18	15407	245029	50344670
Diabetic metabolic decompensation	31.15	17.13	13	15412	1467	50588232
Treatment failure	31.09	17.13	3	15422	137634	50452065
Necrotising myositis	30.29	17.13	9	15416	371	50589328
Disturbance in attention	29.94	17.13	42	15383	31144	50558555
Cerebral haematoma	29.69	17.13	16	15409	3195	50586504
Walking disability	29.36	17.13	12	15413	1284	50588415
Helplessness	28.94	17.13	8	15417	254	50589445
Myopathy	28.35	17.13	23	15402	9116	50580583
Hallucination, gustatory	27.61	17.13	6	15419	67	50589632
Spontaneous haematoma	27.56	17.13	10	15415	776	50588923
Contraindicated product prescribed	27.42	17.13	10	15415	787	50588912
Tongue oedema	27.02	17.13	16	15409	3823	50585876
Mental status changes postoperative	26.88	17.13	7	15418	176	50589523
Rhabdomyolysis	26.80	17.13	45	15380	38982	50550717
Convulsive threshold lowered	26.76	17.13	8	15417	337	50589362
Renal artery stenosis	26.42	17.13	12	15413	1660	50588039
Nasopharyngitis	26.25	17.13	13	15412	192914	50396785
Confusion postoperative	26.16	17.13	7	15418	196	50589503
Hyperglycaemic hyperosmolar nonketotic syndrome	25.96	17.13	9	15416	611	50589088
Radiation fibrosis	25.22	17.13	5	15420	34	50589665
Pulmonary vein occlusion	25.10	17.13	6	15419	105	50589594
Altered state of consciousness	24.84	17.13	32	15393	21878	50567821
Poisoning deliberate	24.73	17.13	20	15405	7892	50581807
Polyneuropathy	24.60	17.13	24	15401	12107	50577592
Cardiac failure	24.24	17.13	64	15361	75976	50513723
Retroperitoneal fibrosis	23.62	17.13	7	15418	286	50589413
Arthralgia	23.47	17.13	63	15362	438639	50151060
Prothrombin time shortened	23.34	17.13	11	15414	1656	50588043
Rhonchi	22.75	17.13	12	15413	2295	50587404
Arterial spasm	22.68	17.13	5	15420	60	50589639
Hypovolaemic shock	22.62	17.13	16	15409	5172	50584527
Suicide attempt	22.36	17.13	49	15376	51683	50538016
Intestinal villi atrophy	22.26	17.13	6	15419	173	50589526
Miosis	21.98	17.13	17	15408	6293	50583406
Acute pulmonary oedema	21.94	17.13	18	15407	7249	50582450
Adenocarcinoma metastatic	21.64	17.13	5	15420	75	50589624
Pseudophaeochromocytoma	21.52	17.13	5	15420	77	50589622
Ultrasound liver abnormal	21.22	17.13	4	15421	20	50589679
Arrhythmia	21.17	17.13	37	15388	33095	50556604
Degenerative mitral valve disease	21.06	17.13	4	15421	21	50589678
Postural tremor	21.01	17.13	6	15419	215	50589484
Hallucination, olfactory	20.82	17.13	6	15419	222	50589477
White blood cell count decreased	20.80	17.13	5	15420	116717	50472982
Product monitoring error	20.72	17.13	12	15413	2752	50586947
Haematoma	20.71	17.13	35	15390	30475	50559224
Metabolic acidosis	20.58	17.13	40	15385	38785	50550914
Rash maculo-papular	20.02	17.13	32	15393	26609	50563090
Shock haemorrhagic	19.78	17.13	18	15407	8326	50581373
Presyncope	19.48	17.13	30	15395	24168	50565531
Frontotemporal dementia	19.38	17.13	6	15419	285	50589414
Traumatic haematoma	19.20	17.13	9	15416	1338	50588361
Overdose	18.84	17.13	70	15355	99657	50490042
Tinnitus	18.73	17.13	32	15393	28100	50561599
Somnolence	18.68	17.13	95	15330	154890	50434809
Cerebral salt-wasting syndrome	18.63	17.13	4	15421	42	50589657
Wrong product administered	17.71	17.13	14	15411	5346	50584353
Hepatic enzyme increased	17.59	17.13	10	15415	137370	50452329
Gamma-glutamyltransferase increased	17.53	17.13	32	15393	29591	50560108
Blood creatinine increased	17.45	17.13	57	15368	76103	50513596

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	200.59	16.20	388	12489	264879	29296771
General physical health deterioration	76.53	16.20	150	12727	102707	29458943
Lactic acidosis	72.30	16.20	77	12800	30170	29531480
Hyperkalaemia	65.63	16.20	105	12772	61287	29500363
Hepatic vein dilatation	60.12	16.20	15	12862	217	29561433
Atrial enlargement	59.18	16.20	16	12861	322	29561328
Liver palpable	56.80	16.20	15	12862	275	29561375
Death	54.23	16.20	42	12835	342042	29219608
Pemphigoid	53.36	16.20	36	12841	7545	29554105
Narrow anterior chamber angle	53.20	16.20	12	12865	109	29561541
Hyponatraemia	51.90	16.20	100	12777	67533	29494117
Metabolic acidosis	48.10	16.20	70	12807	37592	29524058
Inappropriate antidiuretic hormone secretion	45.74	16.20	38	12839	10894	29550756
Ventricular enlargement	45.55	16.20	14	12863	450	29561200
Inferior vena cava dilatation	44.25	16.20	15	12862	662	29560988
Drug ineffective	41.35	16.20	59	12818	363111	29198539
Hypomagnesaemia	40.89	16.20	44	12833	17424	29544226
Lens dislocation	38.76	16.20	9	12868	94	29561556
Syncope	38.32	16.20	99	12778	81272	29480378
Vascular purpura	36.87	16.20	16	12861	1387	29560263
Meningorrhagia	36.68	16.20	9	12868	121	29561529
Hypokalaemia	35.79	16.20	72	12805	50131	29511519
Supine hypertension	33.13	16.20	10	12867	302	29561348
Retinal artery occlusion	31.54	16.20	15	12862	1608	29560042
Haematochezia	31.22	16.20	57	12820	36926	29524724
Product dose omission issue	31.11	16.20	3	12874	96380	29465270
Hypertensive crisis	30.20	16.20	26	12851	7822	29553828
Bradycardia	30.01	16.20	79	12798	65550	29496100
Sprue-like enteropathy	29.75	16.20	10	12867	430	29561220
Dyspnoea at rest	29.39	16.20	18	12859	3196	29558454
Pancreatitis acute	29.22	16.20	44	12833	24341	29537309
Electrocardiogram QT prolonged	28.38	16.20	54	12823	36083	29525567
Coronary artery stenosis	28.22	16.20	26	12851	8547	29553103
Abdominal compartment syndrome	26.82	16.20	11	12866	828	29560822
Mesenteric artery thrombosis	26.27	16.20	9	12868	410	29561240
Completed suicide	26.20	16.20	4	12873	90242	29471408
Renal artery arteriosclerosis	25.28	16.20	5	12872	22	29561628
Rash maculo-papular	25.17	16.20	41	12836	24248	29537402
Hepatocellular injury	24.98	16.20	38	12839	21205	29540445
Cholestasis	24.85	16.20	40	12837	23422	29538228
Mesenteric vein thrombosis	24.75	16.20	9	12868	489	29561161
Wrong drug	24.57	16.20	6	12871	79	29561571
Nephroangiosclerosis	24.56	16.20	7	12870	172	29561478
Drug abuse	24.47	16.20	3	12874	79880	29481770
Cardiac failure chronic	24.02	16.20	21	12856	6446	29555204
Hemiplegia	23.67	16.20	21	12856	6573	29555077
Vasoplegia syndrome	23.53	16.20	12	12865	1496	29560154
Implant site inflammation	22.93	16.20	6	12871	106	29561544
Interstitial lung disease	22.92	16.20	66	12811	57652	29503998
Cell death	22.76	16.20	13	12864	2031	29559619
Oedema peripheral	22.50	16.20	97	12780	103460	29458190
Ischaemic stroke	22.30	16.20	31	12846	15946	29545704
Presyncope	22.14	16.20	31	12846	16058	29545592
Post thrombotic syndrome	21.81	16.20	6	12871	129	29561521
Renal artery restenosis	21.42	16.20	4	12873	12	29561638
Bundle branch block right	21.39	16.20	20	12857	6697	29554953
Laryngeal leukoplakia	21.30	16.20	5	12872	55	29561595
Eosinophilia	21.08	16.20	36	12841	22125	29539525
Hypoglycaemia	20.88	16.20	57	12820	48289	29513361
Respiratory alkalosis	20.84	16.20	11	12866	1472	29560178
Coma	20.64	16.20	50	12827	39400	29522250
Agranulocytosis	20.62	16.20	34	12843	20306	29541344
Retinal vein occlusion	20.55	16.20	11	12866	1514	29560136
Cerebral haematoma	20.22	16.20	16	12861	4280	29557370
Drug interaction	20.21	16.20	151	12726	197234	29364416
Anti factor VIII antibody positive	19.81	16.20	5	12872	76	29561574
Autoimmune enteropathy	19.80	16.20	4	12873	20	29561630
Product monitoring error	19.67	16.20	13	12864	2632	29559018
Torsade de pointes	19.62	16.20	19	12858	6642	29555008
Hyperlactacidaemia	19.52	16.20	13	12864	2665	29558985
Cholangiocarcinoma	19.14	16.20	9	12868	941	29560709
Gallbladder enlargement	19.13	16.20	9	12868	942	29560708
Electrolyte imbalance	19.01	16.20	24	12853	11250	29550400
Platelet count decreased	18.99	16.20	11	12866	104661	29456989
Splenomegaly	18.89	16.20	26	12851	13253	29548397
Haematoma	18.61	16.20	35	12842	23177	29538473
Bradyphrenia	18.36	16.20	15	12862	4199	29557451
Schizophrenia	17.99	16.20	18	12859	6547	29555103
Glycosylated haemoglobin abnormal	17.94	16.20	5	12872	113	29561537
Traumatic haemothorax	17.87	16.20	6	12871	257	29561393
Urethral cancer	17.87	16.20	4	12873	35	29561615
Bundle branch block left	17.36	16.20	16	12861	5261	29556389
Livedo reticularis	17.34	16.20	11	12866	2077	29559573
Hypoglycaemic encephalopathy	17.34	16.20	6	12871	282	29561368
Body mass index abnormal	17.17	16.20	5	12872	133	29561517
Hypotension	16.78	16.20	143	12734	194211	29367439
Basal ganglia haematoma	16.65	16.20	4	12873	49	29561601

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	490.55	14.27	763	26671	448477	64022821
Hyponatraemia	265.52	14.27	321	27113	148018	64323280
General physical health deterioration	210.38	14.27	339	27095	204086	64267212
Hyperkalaemia	168.09	14.27	211	27223	100918	64370380
Lactic acidosis	151.02	14.27	157	27277	61253	64410045
Pemphigoid	113.36	14.27	70	27364	12916	64458382
Cholestasis	110.79	14.27	115	27319	44757	64426541
Hypokalaemia	107.64	14.27	189	27245	121714	64349584
Hypotension	104.22	14.27	377	27057	380597	64090701
Drug ineffective	99.97	14.27	127	27307	840120	63631178
Fall	89.29	14.27	382	27052	416444	64054854
Cell death	87.51	14.27	40	27394	4014	64467284
Hepatocellular injury	85.83	14.27	101	27333	45134	64426164
Eosinophilia	80.65	14.27	90	27344	37986	64433312
Completed suicide	78.92	14.27	4	27430	224410	64246888
Death	78.28	14.27	55	27379	482650	63988648
Vasoplegia syndrome	78.20	14.27	33	27401	2734	64468564
Pallor	72.59	14.27	86	27348	38695	64432603
Bradycardia	69.98	14.27	155	27279	118064	64353234
Sprue-like enteropathy	68.57	14.27	23	27411	1006	64470292
Pain	67.38	14.27	82	27352	553429	63917869
Anaemia	66.85	14.27	328	27106	378352	64092946
Ischaemic stroke	65.59	14.27	71	27363	28964	64442334
Metabolic acidosis	62.56	14.27	110	27324	70848	64400450
Labile hypertension	60.94	14.27	18	27416	516	64470782
Hypertensive crisis	60.50	14.27	55	27379	18193	64453105
Haematochezia	59.95	14.27	104	27330	66269	64405029
Hepatic vein dilatation	59.47	14.27	15	27419	233	64471065
Confusional state	57.06	14.27	241	27193	260903	64210395
Electrocardiogram QT prolonged	56.11	14.27	112	27322	79336	64391962
Liver palpable	54.47	14.27	15	27419	332	64470966
Inappropriate antidiuretic hormone secretion	52.98	14.27	56	27378	22233	64449065
Drug interaction	52.43	14.27	297	27137	361786	64109512
Hyperlactacidaemia	52.42	14.27	30	27404	4814	64466484
Nasopharyngitis	52.29	14.27	10	27424	196063	64275235
Product dose omission issue	51.79	14.27	10	27424	194737	64276561
Labelled drug-drug interaction medication error	51.68	14.27	55	27379	22007	64449291
Atrial fibrillation	50.64	14.27	174	27260	170915	64300383
Drug hypersensitivity	50.50	14.27	19	27415	237796	64233502
Syncope	49.91	14.27	164	27270	157471	64313827
Infusion related reaction	49.29	14.27	6	27428	164461	64306837
Narrow anterior chamber angle	49.28	14.27	12	27422	160	64471138
Product prescribing error	48.32	14.27	67	27367	35202	64436096
Sinusitis	47.16	14.27	4	27430	145924	64325374
Cerebral haematoma	46.23	14.27	32	27402	7153	64464145
Anuria	45.70	14.27	48	27386	18916	64452382
Swelling	45.29	14.27	7	27427	160211	64311087
Ventricular enlargement	44.22	14.27	14	27420	509	64470789
Inferior vena cava dilatation	43.00	14.27	15	27419	739	64470559
Rash maculo-papular	41.56	14.27	73	27361	46953	64424345
Presyncope	41.26	14.27	62	27372	35027	64436271
Atrial enlargement	41.02	14.27	14	27420	646	64470652
Oedema peripheral	39.78	14.27	186	27248	210131	64261167
Creutzfeldt-Jakob disease	38.69	14.27	10	27424	172	64471126
Rheumatoid arthritis	38.61	14.27	11	27423	164283	64307015
Arthropathy	37.28	14.27	4	27430	120963	64350335
Orthostatic hypotension	36.79	14.27	69	27365	46669	64424629
Product monitoring error	36.76	14.27	25	27409	5429	64465869
Renin increased	36.63	14.27	10	27424	214	64471084
Lens dislocation	36.55	14.27	9	27425	126	64471172
Supine hypertension	36.14	14.27	11	27423	350	64470948
Haematoma	36.06	14.27	68	27366	46182	64425116
Medication error	35.94	14.27	71	27363	49895	64421403
Interstitial lung disease	33.94	14.27	105	27329	97627	64373671
Vascular purpura	33.62	14.27	18	27416	2538	64468760
Abdominal discomfort	33.32	14.27	18	27416	182304	64288994
Treatment failure	33.24	14.27	5	27429	116811	64354487
Therapeutic product effect decreased	32.68	14.27	5	27429	115346	64355952
Alopecia	32.32	14.27	15	27419	165675	64305623
Acute pulmonary oedema	31.90	14.27	33	27401	12776	64458522
White blood cell count decreased	31.24	14.27	14	27420	157823	64313475
Hypovolaemic shock	30.28	14.27	29	27405	10237	64461061
Meningorrhagia	30.14	14.27	9	27425	268	64471030
Toxic skin eruption	30.03	14.27	39	27395	19245	64452053
Pancreatitis acute	29.74	14.27	60	27374	42795	64428503
Overdose	29.33	14.27	140	27294	159426	64311872
Hypomagnesaemia	29.19	14.27	55	27379	37321	64433977
Dyspnoea at rest	29.04	14.27	23	27411	6306	64464992
Helplessness	28.70	14.27	9	27425	317	64470981
Altered state of consciousness	28.64	14.27	55	27379	37847	64433451
Platelet count decreased	28.60	14.27	18	27416	167693	64303605
Immune-mediated pancreatitis	28.43	14.27	7	27427	98	64471200
Mesenteric artery thrombosis	27.88	14.27	10	27424	535	64470763
Shock haemorrhagic	27.78	14.27	35	27399	16756	64454542
Cardiac failure	27.19	14.27	120	27314	132253	64339045
Renal failure	26.86	14.27	150	27284	181538	64289760
Epileptic encephalopathy	26.67	14.27	9	27425	401	64470897
Suicide attempt	26.25	14.27	78	27356	70929	64400369
Retinal artery occlusion	26.23	14.27	16	27418	2887	64468411
Hypocalcaemia	26.10	14.27	56	27378	41697	64429601
Tongue oedema	25.85	14.27	21	27413	5969	64465329
Coma	25.79	14.27	89	27345	87526	64383772
Hallucination, gustatory	25.53	14.27	6	27428	68	64471230
Asthma	25.07	14.27	5	27429	95220	64376078
Nephroangiosclerosis	24.85	14.27	8	27426	307	64470991
Oropharyngeal pain	24.84	14.27	4	27430	88863	64382435
Bundle branch block right	24.76	14.27	26	27408	10243	64461055
Coronary artery stenosis	24.52	14.27	27	27407	11221	64460077
Tachycardia	24.48	14.27	127	27307	149452	64321846
Walking disability	24.24	14.27	13	27421	1838	64469460
Arthralgia	23.82	14.27	102	27332	442158	64029140
Haematemesis	23.80	14.27	58	27376	46941	64424357
Electrocardiogram abnormal	23.75	14.27	29	27405	13452	64457846
Cardiac failure congestive	23.70	14.27	13	27421	130567	64340731
Hypoglycaemia	23.64	14.27	88	27346	89804	64381494
Pneumonia	23.36	14.27	141	27293	559435	63911863
Radiation fibrosis	23.19	14.27	5	27429	37	64471261
Disease progression	23.08	14.27	16	27418	141664	64329634
Spontaneous haematoma	22.69	14.27	11	27423	1260	64470038
Diabetic metabolic decompensation	22.03	14.27	14	27420	2714	64468584
Cardiac failure chronic	21.99	14.27	23	27411	9018	64462280
Pulmonary vein occlusion	21.87	14.27	6	27428	131	64471167
Injection site pain	21.85	14.27	10	27424	111398	64359900
Bundle branch block left	21.72	14.27	24	27410	10010	64461288
Renal dysplasia	21.51	14.27	4	27430	12	64471286
Renal artery restenosis	21.51	14.27	4	27430	12	64471286
Abdominal compartment syndrome	21.47	14.27	11	27423	1417	64469881
Laryngeal leukoplakia	21.33	14.27	5	27429	56	64471242
Acute coronary syndrome	21.12	14.27	33	27401	19277	64452021
Renal artery stenosis	20.95	14.27	14	27420	2955	64468343
Mental status changes postoperative	20.73	14.27	6	27428	160	64471138
Drug intolerance	20.60	14.27	30	27404	187962	64283336
Dyspnoea	20.34	14.27	423	27011	718251	63753047
Sopor	19.95	14.27	41	27393	29620	64441678
Necrotising myositis	19.86	14.27	9	27425	885	64470413
Anti factor VIII antibody positive	19.80	14.27	5	27429	78	64471220
Mobility decreased	19.69	14.27	6	27428	85834	64385464
Hospitalisation	19.69	14.27	4	27430	75203	64396095
Intestinal villi atrophy	19.58	14.27	7	27427	371	64470927
Confusion postoperative	19.45	14.27	6	27428	200	64471098
Joint swelling	19.36	14.27	39	27395	215343	64255955
Therapeutic product effect incomplete	19.22	14.27	10	27424	103472	64367826
Angina pectoris	19.07	14.27	52	27382	45029	64426269
Pseudophaeochromocytoma	19.03	14.27	5	27429	92	64471206
Arthritis	18.97	14.27	6	27428	83808	64387490
Implant site inflammation	18.93	14.27	6	27428	219	64471079
Product use issue	18.89	14.27	22	27412	151693	64319605
Adenocarcinoma metastatic	18.78	14.27	5	27429	97	64471201
Wrong drug	18.60	14.27	6	27428	232	64471066
Traumatic haematoma	18.32	14.27	11	27423	1929	64469369
Atrioventricular block	18.24	14.27	24	27410	11991	64459307
Agranulocytosis	18.11	14.27	46	27388	38183	64433115
Renal artery arteriosclerosis	17.86	14.27	4	27430	36	64471262
Bradyphrenia	17.83	14.27	21	27413	9385	64461913
Autoimmune enteropathy	17.57	14.27	4	27430	39	64471259
Renal cyst	17.39	14.27	24	27410	12546	64458752
Frontotemporal dementia	17.35	14.27	7	27427	517	64470781
Hypersensitivity	17.29	14.27	36	27398	196416	64274882
Melaena	17.18	14.27	56	27378	53492	64417806
Migraine	17.12	14.27	3	27431	62674	64408624
Electrolyte imbalance	17.11	14.27	35	27399	25208	64446090
Hemiplegia	17.10	14.27	24	27410	12744	64458554
Glycosylated haemoglobin abnormal	17.04	14.27	5	27429	140	64471158
Neuropathy peripheral	16.96	14.27	15	27419	117510	64353788
Headache	16.93	14.27	144	27290	529323	63941975
Rhonchi	16.79	14.27	13	27421	3450	64467848
Retroperitoneal fibrosis	16.73	14.27	7	27427	568	64470730
Convulsive threshold lowered	16.71	14.27	8	27426	891	64470407
Urethral cancer	16.66	14.27	4	27430	50	64471248
Amyotrophy	16.54	14.27	7	27427	584	64470714
Arterial spasm	16.49	14.27	5	27429	157	64471141
Nocturia	16.48	14.27	22	27412	11143	64460155
Tongue neoplasm malignant stage unspecified	16.45	14.27	8	27426	922	64470376
Myopathy	16.34	14.27	28	27406	17652	64453646
Pneumocystis jirovecii infection	16.34	14.27	11	27423	2350	64468948
Musculoskeletal stiffness	16.29	14.27	17	27417	123189	64348109
Hyperglycaemia	16.29	14.27	60	27374	60908	64410390
Discomfort	16.27	14.27	7	27427	80871	64390427
Systemic infection	16.27	14.27	14	27420	4307	64466991
Basal ganglia haematoma	16.18	14.27	4	27430	57	64471241
Gallbladder enlargement	16.12	14.27	9	27425	1377	64469921
Livedo reticularis	16.04	14.27	13	27421	3684	64467614
Intermittent claudication	15.98	14.27	12	27422	3042	64468256
Fluid retention	15.96	14.27	3	27431	59603	64411695
Angioedema	15.81	14.27	60	27374	61761	64409537
Traumatic haemothorax	15.55	14.27	6	27428	394	64470904
Respiratory alkalosis	15.44	14.27	13	27421	3884	64467414
Prerenal failure	15.41	14.27	12	27422	3210	64468088
Torsade de pointes	15.39	14.27	27	27407	17336	64453962
Acute generalised exanthematous pustulosis	15.34	14.27	24	27410	14034	64457264
Intracranial mass	15.30	14.27	10	27424	2033	64469265
Claudication of jaw muscles	15.15	14.27	4	27430	75	64471223
Delusional disorder, unspecified type	15.09	14.27	7	27427	726	64470572
Oxygen saturation decreased	15.08	14.27	14	27420	107162	64364136
Body mass index abnormal	15.01	14.27	5	27429	214	64471084
C-reactive protein decreased	14.98	14.27	10	27424	2106	64469192
Miosis	14.97	14.27	23	27411	13243	64458055
Depression	14.97	14.27	35	27399	183256	64288042
Weight increased	14.94	14.27	44	27390	213304	64257994
Infected lymphocele	14.85	14.27	5	27429	221	64471077
Hallucination, olfactory	14.80	14.27	6	27428	449	64470849
Hallucination, visual	14.79	14.27	35	27399	27799	64443499
Poisoning deliberate	14.72	14.27	23	27411	13435	64457863
Splenic rupture	14.55	14.27	10	27424	2209	64469089
Prothrombin time shortened	14.48	14.27	11	27423	2838	64468460
White blood cell count increased	14.46	14.27	5	27429	66009	64405289
Seizure	14.33	14.27	31	27403	166861	64304437
Crowned dens syndrome	14.32	14.27	3	27431	19	64471279

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C08CA13	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives
ATC	C09BB02	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers
ATC	C09DB08	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D049990	Membrane Transport Modulators

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.96	Basic
pKa2	2.09	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Voltage-gated L-type calcium channel	Ion channel	Q01668 Q13936	CAC1D_HUMAN CAC1C_HUMAN	BLOCKER				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D01849	KEGG_DRUG
132866-11-6	SECONDARY_CAS_RN
C0526399	UMLSCUI
CHEBI:31771	CHEBI
CHEMBL250270	ChEMBL_ID
CHEMBL2106419	ChEMBL_ID
DB00528	DRUGBANK_ID
C060343	MESH_SUPPLEMENTAL_RECORD_UI
6971	INN_ID
V7XTJ4R0BH	UNII
65866	PUBCHEM_CID
135056	RXNORM
007361	NDDF
007362	NDDF
356862006	SNOMEDCT_US
395768003	SNOMEDCT_US
395986007	SNOMEDCT_US

Pharmaceutical products:

None