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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
FAQ
Scroll
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
remikiren 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
renin inhibitors
4696
126222-34-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
remikiren
Ro 42-5892
Ro-42-5892
renin inhibitor under development for the treatment of hypertension
Molecular weight: 630.85
Formula: C33H50N4O6S
CLOGP: 3.55
LIPINSKI: 1
HAC: 10
HDO: 5
TPSA: 161.48
ALOGS: -4.46
ROTB: 16
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
t_half (Half-life)
5.20 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
11.60 mL/min/kg
Lombardo F, Berellini G, Obach RS
BA (Bioavailability)
1 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)
0.77 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.06 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 5 of 5 entries
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C09XA01
CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
CHEBI has role
CHEBI:35620
vasodilator agents
CHEBI has role
CHEBI:35674
antihypertensive drugs
CHEBI has role
CHEBI:63175
peptidomimetics
CHEBI has role
CHEBI:166822
EC 3.4.23.15 (renin) inhibitors
MeSH PA
D000959
Antihypertensive Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D011480
Protease Inhibitors
Showing 1 to 9 of 9 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.24
acidic
pKa2
13.82
acidic
pKa3
6.69
Basic
Showing 1 to 3 of 3 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Renin
Enzyme
P00797
RENI_HUMAN
INHIBITOR
IC50
9.16
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Showing 1 to 1 of 1 entries
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External reference:
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ID
Source
REM
PDB_CHEM_ID
6324659
PUBCHEM_CID
6876
INN_ID
C0209499
UMLSCUI
C065581
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:8803
CHEBI
CHEMBL31601
ChEMBL_ID
D09038
KEGG_DRUG
DB00212
DRUGBANK_ID
LC7FBL96A4
UNII
Showing 1 to 10 of 10 entries
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Pharmaceutical products:
None
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remikiren