telmisartan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin II receptor antagonists, antihypertensive (non-peptidic) | 2583 | 144701-48-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 40 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.22 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 5.30 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 8.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.00 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 20 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 12, 1998 | EMA | KRKA, D.D., NOVO MESTO | |
| Nov. 10, 1998 | FDA | BOEHRINGER INGELHEIM |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hyponatraemia | 186.88 | 10.62 | 303 | 43928 | 111597 | 63333194 |
| Blood pressure increased | 117.47 | 10.62 | 311 | 43920 | 161751 | 63283040 |
| Pemphigus | 103.80 | 10.62 | 6 | 44225 | 183720 | 63261071 |
| Alopecia | 86.90 | 10.62 | 65 | 44166 | 337471 | 63107320 |
| Hypertensive crisis | 86.03 | 10.62 | 77 | 44154 | 15209 | 63429582 |
| Bradycardia | 85.80 | 10.62 | 170 | 44061 | 73057 | 63371734 |
| Maternal exposure during pregnancy | 79.60 | 10.62 | 27 | 44204 | 220035 | 63224756 |
| Blood pressure systolic increased | 75.85 | 10.62 | 126 | 44105 | 47271 | 63397520 |
| Renal impairment | 71.66 | 10.62 | 177 | 44054 | 88178 | 63356613 |
| Glossodynia | 68.15 | 10.62 | 20 | 44211 | 178856 | 63265935 |
| Abdominal discomfort | 67.99 | 10.62 | 74 | 44157 | 320811 | 63123980 |
| Hypoglycaemia | 63.90 | 10.62 | 134 | 44097 | 59931 | 63384860 |
| Anti-cyclic citrullinated peptide antibody positive | 62.10 | 10.62 | 5 | 44226 | 116207 | 63328584 |
| Systemic lupus erythematosus | 60.81 | 10.62 | 35 | 44196 | 208883 | 63235908 |
| Fall | 60.74 | 10.62 | 474 | 43757 | 391860 | 63052931 |
| Endometriosis | 58.88 | 10.62 | 40 | 44191 | 5280 | 63439511 |
| Acute kidney injury | 58.51 | 10.62 | 348 | 43883 | 263067 | 63181724 |
| Hepatic function abnormal | 55.79 | 10.62 | 96 | 44135 | 37046 | 63407745 |
| Labile hypertension | 53.86 | 10.62 | 18 | 44213 | 468 | 63444323 |
| Labelled drug-drug interaction medication error | 53.69 | 10.62 | 56 | 44175 | 13343 | 63431448 |
| Head discomfort | 53.63 | 10.62 | 56 | 44175 | 13359 | 63431432 |
| Hyperkalaemia | 53.15 | 10.62 | 117 | 44114 | 54086 | 63390705 |
| Hemiplegia | 52.53 | 10.62 | 47 | 44184 | 9276 | 63435515 |
| Lactic acidosis | 52.40 | 10.62 | 95 | 44136 | 38192 | 63406599 |
| Glaucoma | 51.97 | 10.62 | 65 | 44166 | 18840 | 63425951 |
| Drug ineffective | 51.74 | 10.62 | 473 | 43758 | 1044292 | 62400499 |
| Arthritis | 50.90 | 10.62 | 187 | 44044 | 115734 | 63329057 |
| Drug specific antibody | 50.27 | 10.62 | 27 | 44204 | 2328 | 63442463 |
| Off label use | 49.63 | 10.62 | 272 | 43959 | 674190 | 62770601 |
| Wound | 49.46 | 10.62 | 26 | 44205 | 163237 | 63281554 |
| Completed suicide | 49.08 | 10.62 | 20 | 44211 | 145653 | 63299138 |
| Cerebral infarction | 48.67 | 10.62 | 71 | 44160 | 23822 | 63420969 |
| Listless | 48.00 | 10.62 | 28 | 44203 | 2832 | 63441959 |
| Pericarditis | 47.80 | 10.62 | 16 | 44215 | 131563 | 63313228 |
| Isosthenuria | 47.69 | 10.62 | 12 | 44219 | 108 | 63444683 |
| Fatigue | 47.01 | 10.62 | 395 | 43836 | 887633 | 62557158 |
| Carcinoid tumour pulmonary | 46.29 | 10.62 | 16 | 44215 | 462 | 63444329 |
| Hand deformity | 45.98 | 10.62 | 27 | 44204 | 159430 | 63285361 |
| Blood pressure decreased | 45.23 | 10.62 | 123 | 44108 | 64899 | 63379892 |
| Rhabdomyolysis | 44.37 | 10.62 | 96 | 44135 | 43855 | 63400936 |
| Carotid artery thrombosis | 43.35 | 10.62 | 26 | 44205 | 2768 | 63442023 |
| Reduced facial expression | 43.26 | 10.62 | 23 | 44208 | 1943 | 63442848 |
| Death | 42.63 | 10.62 | 127 | 44104 | 374254 | 63070537 |
| Breath sounds abnormal | 42.43 | 10.62 | 45 | 44186 | 10928 | 63433863 |
| Altered state of consciousness | 41.60 | 10.62 | 68 | 44163 | 25162 | 63419629 |
| Atrial fibrillation | 41.38 | 10.62 | 176 | 44055 | 116460 | 63328331 |
| Chronic kidney disease | 41.16 | 10.62 | 95 | 44136 | 45303 | 63399488 |
| Inappropriate antidiuretic hormone secretion | 40.66 | 10.62 | 52 | 44179 | 15410 | 63429381 |
| Pyelitis | 40.37 | 10.62 | 12 | 44219 | 210 | 63444581 |
| Affect lability | 40.08 | 10.62 | 44 | 44187 | 11107 | 63433684 |
| Exposure during pregnancy | 39.91 | 10.62 | 30 | 44201 | 155517 | 63289274 |
| Carotid arteriosclerosis | 39.49 | 10.62 | 18 | 44213 | 1088 | 63443703 |
| Bladder hypertrophy | 39.45 | 10.62 | 12 | 44219 | 228 | 63444563 |
| Product dose omission issue | 38.50 | 10.62 | 65 | 44166 | 234248 | 63210543 |
| Pain | 38.42 | 10.62 | 331 | 43900 | 740297 | 62704494 |
| Irritable bowel syndrome | 37.89 | 10.62 | 6 | 44225 | 82406 | 63362385 |
| Swelling | 37.78 | 10.62 | 85 | 44146 | 275293 | 63169498 |
| Postprandial hypoglycaemia | 37.76 | 10.62 | 9 | 44222 | 63 | 63444728 |
| Electrocardiogram PR shortened | 37.50 | 10.62 | 12 | 44219 | 271 | 63444520 |
| Toxic epidermal necrolysis | 37.41 | 10.62 | 65 | 44166 | 25269 | 63419522 |
| Infusion site streaking | 37.40 | 10.62 | 14 | 44217 | 511 | 63444280 |
| Chloropsia | 36.73 | 10.62 | 8 | 44223 | 35 | 63444756 |
| Duodenal ulcer perforation | 36.57 | 10.62 | 8 | 44223 | 87201 | 63357590 |
| Hypotension | 35.51 | 10.62 | 317 | 43914 | 272287 | 63172504 |
| Creatinine renal clearance increased | 34.72 | 10.62 | 14 | 44217 | 625 | 63444166 |
| Blood creatinine increased | 34.67 | 10.62 | 137 | 44094 | 87707 | 63357084 |
| Sleep apnoea syndrome | 34.54 | 10.62 | 68 | 44163 | 29065 | 63415726 |
| Administration site abscess | 34.45 | 10.62 | 7 | 44224 | 20 | 63444771 |
| Blood pressure inadequately controlled | 33.96 | 10.62 | 28 | 44203 | 4950 | 63439841 |
| Apathy | 33.89 | 10.62 | 36 | 44195 | 8758 | 63436033 |
| Neurologic neglect syndrome | 33.83 | 10.62 | 22 | 44209 | 2699 | 63442092 |
| Administration site induration | 33.72 | 10.62 | 7 | 44224 | 23 | 63444768 |
| Blood pressure abnormal | 33.65 | 10.62 | 47 | 44184 | 15151 | 63429640 |
| Administration site discharge | 32.64 | 10.62 | 7 | 44224 | 28 | 63444763 |
| Helicobacter infection | 32.47 | 10.62 | 12 | 44219 | 92773 | 63352018 |
| Muscle injury | 31.82 | 10.62 | 4 | 44227 | 65341 | 63379450 |
| Impaired healing | 31.53 | 10.62 | 16 | 44215 | 102526 | 63342265 |
| Oliguria | 31.14 | 10.62 | 35 | 44196 | 9066 | 63435725 |
| Hypokalaemia | 31.09 | 10.62 | 149 | 44082 | 103655 | 63341136 |
| Arthropathy | 30.97 | 10.62 | 74 | 44157 | 234718 | 63210073 |
| Skin necrosis | 30.68 | 10.62 | 43 | 44188 | 13907 | 63430884 |
| Asthma | 30.53 | 10.62 | 172 | 44059 | 127389 | 63317402 |
| Drug eruption | 30.49 | 10.62 | 64 | 44167 | 28630 | 63416161 |
| Cardiac failure | 30.45 | 10.62 | 133 | 44098 | 89009 | 63355782 |
| Administration site odour | 30.44 | 10.62 | 7 | 44224 | 41 | 63444750 |
| Myalgia | 30.21 | 10.62 | 190 | 44041 | 146339 | 63298452 |
| Granuloma skin | 29.82 | 10.62 | 33 | 44198 | 8404 | 63436387 |
| Product packaging confusion | 29.74 | 10.62 | 9 | 44222 | 168 | 63444623 |
| Arterial occlusive disease | 29.61 | 10.62 | 28 | 44203 | 5930 | 63438861 |
| Therapeutic product effect decreased | 28.68 | 10.62 | 57 | 44174 | 193130 | 63251661 |
| Psoriasis | 28.38 | 10.62 | 128 | 44103 | 86829 | 63357962 |
| Blood thyroid stimulating hormone normal | 28.38 | 10.62 | 8 | 44223 | 115 | 63444676 |
| Ill-defined disorder | 27.89 | 10.62 | 11 | 44220 | 81744 | 63363047 |
| Injection site cyst | 27.52 | 10.62 | 7 | 44224 | 66 | 63444725 |
| Ureteral disorder | 27.25 | 10.62 | 10 | 44221 | 345 | 63444446 |
| Albuminuria | 26.93 | 10.62 | 9 | 44222 | 234 | 63444557 |
| White blood cell count abnormal | 26.66 | 10.62 | 27 | 44204 | 6215 | 63438576 |
| Joint noise | 26.46 | 10.62 | 23 | 44208 | 4369 | 63440422 |
| Interstitial lung disease | 26.43 | 10.62 | 99 | 44132 | 61809 | 63382982 |
| Panniculitis | 26.40 | 10.62 | 36 | 44195 | 11349 | 63433442 |
| Vascular purpura | 26.21 | 10.62 | 15 | 44216 | 1463 | 63443328 |
| Dementia | 26.18 | 10.62 | 47 | 44184 | 18747 | 63426044 |
| Hypersensitivity | 26.12 | 10.62 | 110 | 44121 | 292575 | 63152216 |
| Blood parathyroid hormone decreased | 25.85 | 10.62 | 33 | 44198 | 9758 | 63435033 |
| Hypertensive angiopathy | 25.84 | 10.62 | 7 | 44224 | 86 | 63444705 |
| Vertigo | 25.76 | 10.62 | 96 | 44135 | 59791 | 63385000 |
| Gouty arthritis | 25.73 | 10.62 | 11 | 44220 | 570 | 63444221 |
| Disease progression | 25.20 | 10.62 | 29 | 44202 | 122729 | 63322062 |
| Infection | 25.15 | 10.62 | 79 | 44152 | 229094 | 63215697 |
| Oxygen saturation decreased | 24.98 | 10.62 | 125 | 44106 | 88460 | 63356331 |
| Gastric pH increased | 24.93 | 10.62 | 6 | 44225 | 44 | 63444747 |
| Staphylococcus test positive | 24.68 | 10.62 | 21 | 44210 | 3875 | 63440916 |
| Administration site haemorrhage | 24.56 | 10.62 | 7 | 44224 | 105 | 63444686 |
| Foreign body | 24.50 | 10.62 | 17 | 44214 | 2321 | 63442470 |
| Loss of consciousness | 24.23 | 10.62 | 153 | 44078 | 117968 | 63326823 |
| Prescription drug used without a prescription | 24.19 | 10.62 | 17 | 44214 | 2369 | 63442422 |
| Muscle atrophy | 23.99 | 10.62 | 27 | 44204 | 7006 | 63437785 |
| Haemoglobin increased | 23.81 | 10.62 | 20 | 44211 | 3626 | 63441165 |
| Renal function test abnormal | 23.78 | 10.62 | 20 | 44211 | 3633 | 63441158 |
| Electrocardiogram PR prolongation | 23.41 | 10.62 | 11 | 44220 | 713 | 63444078 |
| Tender joint count | 23.41 | 10.62 | 8 | 44223 | 223 | 63444568 |
| Blood pressure diastolic decreased | 23.37 | 10.62 | 50 | 44181 | 22656 | 63422135 |
| Contraindicated product administered | 23.20 | 10.62 | 76 | 44155 | 217572 | 63227219 |
| Product use in unapproved indication | 23.16 | 10.62 | 57 | 44174 | 179023 | 63265768 |
| Scoliosis | 23.09 | 10.62 | 28 | 44203 | 7860 | 63436931 |
| Urinary retention | 22.77 | 10.62 | 59 | 44172 | 30242 | 63414549 |
| Porphyrins urine increased | 22.75 | 10.62 | 5 | 44226 | 23 | 63444768 |
| Acquired porphyria | 22.75 | 10.62 | 5 | 44226 | 23 | 63444768 |
| Sinus congestion | 22.33 | 10.62 | 43 | 44188 | 18080 | 63426711 |
| Treatment failure | 22.27 | 10.62 | 68 | 44163 | 198975 | 63245816 |
| Endophthalmitis | 22.02 | 10.62 | 19 | 44212 | 3573 | 63441218 |
| Product monitoring error | 22.02 | 10.62 | 21 | 44210 | 4495 | 63440296 |
| Gangrene | 21.73 | 10.62 | 24 | 44207 | 6099 | 63438692 |
| Porphyrins stool increased | 21.64 | 10.62 | 5 | 44226 | 30 | 63444761 |
| Blood creatine phosphokinase increased | 21.59 | 10.62 | 58 | 44173 | 30372 | 63414419 |
| Stomatitis | 21.40 | 10.62 | 40 | 44191 | 138685 | 63306106 |
| Fibromyalgia | 21.28 | 10.62 | 15 | 44216 | 80405 | 63364386 |
| Carbohydrate antigen 15-3 increased | 21.24 | 10.62 | 13 | 44218 | 1435 | 63443356 |
| Non-small cell lung cancer recurrent | 21.05 | 10.62 | 6 | 44225 | 90 | 63444701 |
| Cerebrovascular accident | 20.98 | 10.62 | 138 | 44093 | 107886 | 63336905 |
| Renal failure | 20.88 | 10.62 | 147 | 44084 | 117505 | 63327286 |
| Cystitis | 20.28 | 10.62 | 84 | 44147 | 54907 | 63389884 |
| Allergy to metals | 20.23 | 10.62 | 10 | 44221 | 725 | 63444066 |
| Hypercalcaemia | 20.11 | 10.62 | 54 | 44177 | 28268 | 63416523 |
| Delirium | 20.07 | 10.62 | 79 | 44152 | 50462 | 63394329 |
| Hypertension | 20.00 | 10.62 | 289 | 43942 | 279014 | 63165777 |
| Blood pressure diastolic abnormal | 19.78 | 10.62 | 36 | 44195 | 14506 | 63430285 |
| Urine calcium/creatinine ratio increased | 19.73 | 10.62 | 6 | 44225 | 114 | 63444677 |
| Product use issue | 19.58 | 10.62 | 83 | 44148 | 220437 | 63224354 |
| Discomfort | 19.57 | 10.62 | 56 | 44175 | 167318 | 63277473 |
| Tracheal pain | 19.49 | 10.62 | 5 | 44226 | 49 | 63444742 |
| Iodine allergy | 19.38 | 10.62 | 10 | 44221 | 794 | 63443997 |
| Carcinoid tumour | 19.31 | 10.62 | 8 | 44223 | 383 | 63444408 |
| Personality disorder | 19.29 | 10.62 | 22 | 44209 | 5789 | 63439002 |
| Cerebral haemorrhage | 19.27 | 10.62 | 56 | 44175 | 30673 | 63414118 |
| Menopausal symptoms | 19.25 | 10.62 | 15 | 44216 | 2446 | 63442345 |
| Insulin-like growth factor decreased | 19.21 | 10.62 | 8 | 44223 | 388 | 63444403 |
| Left ventricular hypertrophy | 19.15 | 10.62 | 21 | 44210 | 5294 | 63439497 |
| Angina pectoris | 19.04 | 10.62 | 55 | 44176 | 30023 | 63414768 |
| Buttock injury | 19.03 | 10.62 | 7 | 44224 | 243 | 63444548 |
| Osteocalcin decreased | 18.96 | 10.62 | 5 | 44226 | 55 | 63444736 |
| Carcinoembryonic antigen increased | 18.89 | 10.62 | 13 | 44218 | 1752 | 63443039 |
| Eczema impetiginous | 18.86 | 10.62 | 4 | 44227 | 15 | 63444776 |
| Sensory loss | 18.81 | 10.62 | 29 | 44202 | 10209 | 63434582 |
| Paralysis recurrent laryngeal nerve | 18.80 | 10.62 | 5 | 44226 | 57 | 63444734 |
| Diabetic nephropathy | 18.68 | 10.62 | 12 | 44219 | 1442 | 63443349 |
| Skin dystrophy | 18.42 | 10.62 | 5 | 44226 | 62 | 63444729 |
| Pemphigoid | 18.22 | 10.62 | 24 | 44207 | 7320 | 63437471 |
| Retinal infarction | 18.20 | 10.62 | 5 | 44226 | 65 | 63444726 |
| Dizziness | 18.08 | 10.62 | 409 | 43822 | 429516 | 63015275 |
| Alanine aminotransferase increased | 18.03 | 10.62 | 129 | 44102 | 103641 | 63341150 |
| Rheumatic fever | 17.98 | 10.62 | 4 | 44227 | 43107 | 63401684 |
| Porphyria non-acute | 17.86 | 10.62 | 7 | 44224 | 290 | 63444501 |
| Bronchiolitis | 17.80 | 10.62 | 15 | 44216 | 2732 | 63442059 |
| Liver injury | 17.79 | 10.62 | 10 | 44221 | 60510 | 63384281 |
| Aphasia | 17.76 | 10.62 | 57 | 44174 | 32943 | 63411848 |
| Thalamus haemorrhage | 17.62 | 10.62 | 9 | 44222 | 700 | 63444091 |
| Cough | 17.56 | 10.62 | 294 | 43937 | 292449 | 63152342 |
| Basal cell carcinoma | 17.54 | 10.62 | 51 | 44180 | 27940 | 63416851 |
| Proteinuria | 17.28 | 10.62 | 40 | 44191 | 19105 | 63425686 |
| Urethral caruncle | 17.01 | 10.62 | 5 | 44226 | 84 | 63444707 |
| Vasoplegia syndrome | 16.98 | 10.62 | 12 | 44219 | 1687 | 63443104 |
| Product used for unknown indication | 16.95 | 10.62 | 8 | 44223 | 524 | 63444267 |
| Dehydration | 16.47 | 10.62 | 189 | 44042 | 173165 | 63271626 |
| Lower respiratory tract infection | 16.42 | 10.62 | 43 | 44188 | 132264 | 63312527 |
| Thyroid disorder | 16.32 | 10.62 | 34 | 44197 | 15128 | 63429663 |
| Blister | 16.25 | 10.62 | 42 | 44189 | 129772 | 63315019 |
| Blood potassium increased | 16.25 | 10.62 | 38 | 44193 | 18271 | 63426520 |
| Aspartate aminotransferase increased | 16.13 | 10.62 | 113 | 44118 | 90164 | 63354627 |
| Electrocardiogram T wave peaked | 16.08 | 10.62 | 6 | 44225 | 217 | 63444574 |
| Left atrial dilatation | 16.00 | 10.62 | 12 | 44219 | 1849 | 63442942 |
| Drug interaction | 15.97 | 10.62 | 236 | 43995 | 228895 | 63215896 |
| Fluid retention | 15.97 | 10.62 | 11 | 44220 | 59675 | 63385116 |
| Swollen joint count increased | 15.75 | 10.62 | 3 | 44228 | 36051 | 63408740 |
| Blood pressure fluctuation | 15.73 | 10.62 | 69 | 44162 | 46248 | 63398543 |
| Immobile | 15.64 | 10.62 | 20 | 44211 | 5923 | 63438868 |
| Blood pressure systolic abnormal | 15.57 | 10.62 | 31 | 44200 | 13355 | 63431436 |
| Myocardial infarction | 15.55 | 10.62 | 121 | 44110 | 99772 | 63345019 |
| Pulse abnormal | 15.51 | 10.62 | 13 | 44218 | 2351 | 63442440 |
| Hyperaldosteronism | 15.51 | 10.62 | 6 | 44225 | 240 | 63444551 |
| Dry gangrene | 15.31 | 10.62 | 8 | 44223 | 652 | 63444139 |
| Eating disorder | 15.30 | 10.62 | 38 | 44193 | 18978 | 63425813 |
| Angioedema | 15.19 | 10.62 | 70 | 44161 | 47895 | 63396896 |
| Hemiparesis | 15.15 | 10.62 | 43 | 44188 | 23239 | 63421552 |
| Clubbing | 15.12 | 10.62 | 7 | 44224 | 439 | 63444352 |
| Acute myocardial infarction | 15.08 | 10.62 | 53 | 44178 | 32071 | 63412720 |
| Skin haemorrhage | 15.03 | 10.62 | 26 | 44205 | 10068 | 63434723 |
| Rash | 15.00 | 10.62 | 288 | 43943 | 560583 | 62884208 |
| XIth nerve injury | 14.85 | 10.62 | 4 | 44227 | 48 | 63444743 |
| Neutropenia | 14.84 | 10.62 | 67 | 44164 | 174938 | 63269853 |
| Uraemic encephalopathy | 14.82 | 10.62 | 6 | 44225 | 271 | 63444520 |
| Suicidal ideation | 14.80 | 10.62 | 13 | 44218 | 62408 | 63382383 |
| Haemorrhage subcutaneous | 14.79 | 10.62 | 14 | 44217 | 2969 | 63441822 |
| Exposure keratitis | 14.78 | 10.62 | 4 | 44227 | 49 | 63444742 |
| Renal tubular acidosis | 14.75 | 10.62 | 11 | 44220 | 1681 | 63443110 |
| Hypokinesia | 14.70 | 10.62 | 31 | 44200 | 13905 | 63430886 |
| Bite | 14.61 | 10.62 | 7 | 44224 | 474 | 63444317 |
| Rheumatoid nodule | 14.57 | 10.62 | 35 | 44196 | 17120 | 63427671 |
| Gastrointestinal disorder | 14.55 | 10.62 | 45 | 44186 | 131194 | 63313597 |
| Confusional state | 14.39 | 10.62 | 238 | 43993 | 236142 | 63208649 |
| Febrile neutropenia | 14.31 | 10.62 | 39 | 44192 | 118410 | 63326381 |
| Glomerular filtration rate decreased | 14.30 | 10.62 | 30 | 44201 | 13411 | 63431380 |
| Subacute cutaneous lupus erythematosus | 14.25 | 10.62 | 13 | 44218 | 2630 | 63442161 |
| Pregnancy | 14.23 | 10.62 | 4 | 44227 | 36832 | 63407959 |
| Meningioma surgery | 14.22 | 10.62 | 4 | 44227 | 57 | 63444734 |
| Adjustment disorder | 14.04 | 10.62 | 14 | 44217 | 3164 | 63441627 |
| Catecholamine crisis | 13.99 | 10.62 | 3 | 44228 | 12 | 63444779 |
| Drug specific antibody present | 13.93 | 10.62 | 16 | 44215 | 4243 | 63440548 |
| Sleep disorder due to a general medical condition | 13.91 | 10.62 | 28 | 44203 | 12160 | 63432631 |
| Motor dysfunction | 13.84 | 10.62 | 26 | 44205 | 10735 | 63434056 |
| Coordination abnormal | 13.80 | 10.62 | 30 | 44201 | 13743 | 63431048 |
| Skin ulcer | 13.77 | 10.62 | 63 | 44168 | 42982 | 63401809 |
| Phlebitis | 13.72 | 10.62 | 20 | 44211 | 6704 | 63438087 |
| Protein urine present | 13.66 | 10.62 | 19 | 44212 | 6101 | 63438690 |
| Palpitations | 13.56 | 10.62 | 129 | 44102 | 112641 | 63332150 |
| Injection site paraesthesia | 13.48 | 10.62 | 7 | 44224 | 563 | 63444228 |
| Hepatic steatosis | 13.11 | 10.62 | 47 | 44184 | 28722 | 63416069 |
| Visual acuity reduced | 12.95 | 10.62 | 39 | 44192 | 21787 | 63423004 |
| Bradypnoea | 12.74 | 10.62 | 14 | 44217 | 3536 | 63441255 |
| Base excess decreased | 12.73 | 10.62 | 4 | 44227 | 85 | 63444706 |
| HLA-B*27 positive | 12.71 | 10.62 | 5 | 44226 | 209 | 63444582 |
| Haemophilia | 12.64 | 10.62 | 4 | 44227 | 87 | 63444704 |
| Gamma-glutamyltransferase increased | 12.56 | 10.62 | 52 | 44179 | 33979 | 63410812 |
| Forced expiratory flow decreased | 12.43 | 10.62 | 4 | 44227 | 92 | 63444699 |
| Arrhythmia | 12.33 | 10.62 | 56 | 44175 | 38084 | 63406707 |
| Knee deformity | 12.30 | 10.62 | 9 | 44222 | 1336 | 63443455 |
| Compensatory sweating | 12.24 | 10.62 | 3 | 44228 | 24 | 63444767 |
| Vocal cord paralysis | 12.21 | 10.62 | 11 | 44220 | 2190 | 63442601 |
| Pelvic fracture | 12.17 | 10.62 | 28 | 44203 | 13320 | 63431471 |
| Influenza like illness | 12.15 | 10.62 | 84 | 44147 | 66740 | 63378051 |
| Drug tolerance decreased | 12.09 | 10.62 | 33 | 44198 | 17440 | 63427351 |
| Intentional product use issue | 12.06 | 10.62 | 47 | 44184 | 127845 | 63316946 |
| Breast cancer recurrent | 12.05 | 10.62 | 15 | 44216 | 4326 | 63440465 |
| Blood glucose decreased | 12.02 | 10.62 | 37 | 44194 | 20915 | 63423876 |
| Rash pruritic | 11.97 | 10.62 | 77 | 44154 | 59722 | 63385069 |
| No adverse event | 11.94 | 10.62 | 7 | 44224 | 41398 | 63403393 |
| Accelerated hypertension | 11.91 | 10.62 | 6 | 44225 | 453 | 63444338 |
| Face oedema | 11.88 | 10.62 | 36 | 44195 | 20176 | 63424615 |
| Sinusitis | 11.81 | 10.62 | 101 | 44130 | 226552 | 63218239 |
| Malaise | 11.80 | 10.62 | 376 | 43855 | 415578 | 63029213 |
| BRASH syndrome | 11.79 | 10.62 | 6 | 44225 | 463 | 63444328 |
| Rubber sensitivity | 11.67 | 10.62 | 11 | 44220 | 2320 | 63442471 |
| Multiple sclerosis relapse | 11.61 | 10.62 | 10 | 44221 | 48468 | 63396323 |
| Near drowning | 11.55 | 10.62 | 3 | 44228 | 31 | 63444760 |
| Sneezing | 11.23 | 10.62 | 33 | 44198 | 18185 | 63426606 |
| Hip arthroplasty | 11.20 | 10.62 | 10 | 44221 | 47636 | 63397155 |
| Pericardial effusion | 11.15 | 10.62 | 46 | 44185 | 30012 | 63414779 |
| Haemorrhagic infarction | 11.13 | 10.62 | 5 | 44226 | 292 | 63444499 |
| Hospitalisation | 11.06 | 10.62 | 27 | 44204 | 85054 | 63359737 |
| Idiosyncratic drug reaction | 11.05 | 10.62 | 7 | 44224 | 821 | 63443970 |
| Mental status changes | 10.99 | 10.62 | 7 | 44224 | 39592 | 63405199 |
| Abortion spontaneous | 10.98 | 10.62 | 10 | 44221 | 47185 | 63397606 |
| Gastrointestinal bacterial infection | 10.85 | 10.62 | 7 | 44224 | 847 | 63443944 |
| Injection site bruising | 10.85 | 10.62 | 8 | 44223 | 41902 | 63402889 |
| Gastrointestinal endoscopic therapy | 10.78 | 10.62 | 3 | 44228 | 41 | 63444750 |
| C-reactive protein increased | 10.73 | 10.62 | 107 | 44124 | 94600 | 63350191 |
| Carotid sinus syndrome | 10.71 | 10.62 | 4 | 44227 | 145 | 63444646 |
| Respiratory tract congestion | 10.71 | 10.62 | 32 | 44199 | 17800 | 63426991 |
| Thyroid mass | 10.69 | 10.62 | 14 | 44217 | 4244 | 63440547 |
| Atrioventricular block complete | 10.69 | 10.62 | 20 | 44211 | 8231 | 63436560 |
| Bradyarrhythmia | 10.62 | 10.62 | 10 | 44221 | 2105 | 63442686 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cerebral infarction | 110.66 | 11.63 | 124 | 28427 | 27331 | 34901049 |
| Interstitial lung disease | 90.17 | 11.63 | 178 | 28373 | 65104 | 34863276 |
| Pericardial disease | 60.31 | 11.63 | 20 | 28531 | 430 | 34927950 |
| Cardiac failure | 59.78 | 11.63 | 187 | 28364 | 91061 | 34837319 |
| Death | 58.07 | 11.63 | 152 | 28399 | 397897 | 34530483 |
| Hepatic function abnormal | 57.67 | 11.63 | 118 | 28433 | 44245 | 34884135 |
| Pulmonary valve disease | 57.22 | 11.63 | 18 | 28533 | 325 | 34928055 |
| Hyperkalaemia | 55.79 | 11.63 | 153 | 28398 | 69236 | 34859144 |
| Completed suicide | 53.83 | 11.63 | 8 | 28543 | 98160 | 34830220 |
| Altered state of consciousness | 50.74 | 11.63 | 77 | 28474 | 22816 | 34905564 |
| Blood creatine phosphokinase increased | 48.78 | 11.63 | 111 | 28440 | 44746 | 34883634 |
| Blood pressure increased | 44.88 | 11.63 | 166 | 28385 | 87936 | 34840444 |
| Growth hormone deficiency | 43.16 | 11.63 | 14 | 28537 | 280 | 34928100 |
| Physical examination abnormal | 42.00 | 11.63 | 14 | 28537 | 306 | 34928074 |
| Acute kidney injury | 37.52 | 11.63 | 397 | 28154 | 304591 | 34623789 |
| Rales | 37.02 | 11.63 | 43 | 28508 | 9840 | 34918540 |
| Hyponatraemia | 36.55 | 11.63 | 149 | 28402 | 82542 | 34845838 |
| Cardiac discomfort | 36.43 | 11.63 | 15 | 28536 | 601 | 34927779 |
| Platelet distribution width increased | 34.55 | 11.63 | 10 | 28541 | 134 | 34928246 |
| Dyslalia | 34.36 | 11.63 | 14 | 28537 | 546 | 34927834 |
| Chronic kidney disease | 34.23 | 11.63 | 92 | 28459 | 41118 | 34887262 |
| Electrocardiogram Q wave abnormal | 33.76 | 11.63 | 13 | 28538 | 436 | 34927944 |
| Neutropenia | 33.06 | 11.63 | 48 | 28503 | 156730 | 34771650 |
| Product dose omission issue | 32.41 | 11.63 | 30 | 28521 | 119681 | 34808699 |
| Dyspnoea at rest | 32.21 | 11.63 | 26 | 28525 | 3802 | 34924578 |
| Stenosis | 31.91 | 11.63 | 18 | 28533 | 1455 | 34926925 |
| Liver disorder | 31.89 | 11.63 | 78 | 28473 | 32919 | 34895461 |
| Toxicity to various agents | 31.06 | 11.63 | 74 | 28477 | 200288 | 34728092 |
| Diabetic nephropathy | 30.60 | 11.63 | 20 | 28531 | 2108 | 34926272 |
| Renal impairment | 30.35 | 11.63 | 155 | 28396 | 94358 | 34834022 |
| Lactic acidosis | 30.27 | 11.63 | 79 | 28472 | 34693 | 34893687 |
| Hepatojugular reflux | 30.09 | 11.63 | 13 | 28538 | 588 | 34927792 |
| Post micturition dribble | 29.76 | 11.63 | 6 | 28545 | 13 | 34928367 |
| Ventricular arrhythmia | 29.46 | 11.63 | 29 | 28522 | 5499 | 34922881 |
| IgA nephropathy | 28.90 | 11.63 | 16 | 28535 | 1247 | 34927133 |
| Off label use | 28.20 | 11.63 | 214 | 28337 | 419310 | 34509070 |
| Carotid artery stenosis | 28.00 | 11.63 | 27 | 28524 | 4992 | 34923388 |
| Daydreaming | 27.67 | 11.63 | 12 | 28539 | 548 | 34927832 |
| Mitral valve disease | 27.16 | 11.63 | 16 | 28535 | 1403 | 34926977 |
| Blood pressure decreased | 26.99 | 11.63 | 98 | 28453 | 51417 | 34876963 |
| Narrow anterior chamber angle | 26.75 | 11.63 | 8 | 28543 | 121 | 34928259 |
| Accident at work | 26.32 | 11.63 | 13 | 28538 | 801 | 34927579 |
| Tricuspid valve incompetence | 26.26 | 11.63 | 36 | 28515 | 9724 | 34918656 |
| Hypoglycaemia | 26.18 | 11.63 | 101 | 28450 | 54539 | 34873841 |
| Haematuria | 26.02 | 11.63 | 95 | 28456 | 49971 | 34878409 |
| Bundle branch block left | 25.79 | 11.63 | 28 | 28523 | 5951 | 34922429 |
| Occult blood | 25.53 | 11.63 | 13 | 28538 | 855 | 34927525 |
| Syncope | 25.30 | 11.63 | 144 | 28407 | 91307 | 34837073 |
| Mitral valve incompetence | 24.65 | 11.63 | 44 | 28507 | 14899 | 34913481 |
| Blood pressure inadequately controlled | 24.51 | 11.63 | 19 | 28532 | 2621 | 34925759 |
| Drug intolerance | 24.49 | 11.63 | 9 | 28542 | 59561 | 34868819 |
| Drug abuse | 24.35 | 11.63 | 27 | 28524 | 99069 | 34829311 |
| Staring | 24.08 | 11.63 | 15 | 28536 | 1455 | 34926925 |
| Drug ineffective | 24.07 | 11.63 | 248 | 28303 | 456503 | 34471877 |
| Loss of consciousness | 23.42 | 11.63 | 131 | 28420 | 82536 | 34845844 |
| Echocardiogram abnormal | 23.05 | 11.63 | 13 | 28538 | 1050 | 34927330 |
| Labile blood pressure | 22.73 | 11.63 | 11 | 28540 | 648 | 34927732 |
| Anaemia macrocytic | 22.23 | 11.63 | 19 | 28532 | 3007 | 34925373 |
| Petit mal epilepsy | 21.95 | 11.63 | 19 | 28532 | 3059 | 34925321 |
| Atrioventricular block complete | 21.58 | 11.63 | 32 | 28519 | 9287 | 34919093 |
| Hypoglycaemic coma | 21.49 | 11.63 | 17 | 28534 | 2414 | 34925966 |
| Helicobacter gastritis | 21.23 | 11.63 | 13 | 28538 | 1223 | 34927157 |
| Incontinence | 21.17 | 11.63 | 25 | 28526 | 5822 | 34922558 |
| Blood urea increased | 20.56 | 11.63 | 63 | 28488 | 30301 | 34898079 |
| Drug eruption | 20.25 | 11.63 | 48 | 28503 | 19850 | 34908530 |
| Myocardial rupture | 20.15 | 11.63 | 7 | 28544 | 174 | 34928206 |
| Oropharyngeal oedema | 19.86 | 11.63 | 6 | 28545 | 94 | 34928286 |
| Product packaging confusion | 19.60 | 11.63 | 5 | 28546 | 40 | 34928340 |
| Hyperuricaemia | 19.17 | 11.63 | 28 | 28523 | 8015 | 34920365 |
| Face oedema | 19.11 | 11.63 | 34 | 28517 | 11482 | 34916898 |
| Renal artery restenosis | 18.91 | 11.63 | 4 | 28547 | 12 | 34928368 |
| Anaplastic astrocytoma | 18.79 | 11.63 | 6 | 28545 | 114 | 34928266 |
| Carotid arteriosclerosis | 18.63 | 11.63 | 14 | 28537 | 1844 | 34926536 |
| Rhabdomyolysis | 18.63 | 11.63 | 107 | 28444 | 68056 | 34860324 |
| Pain | 18.57 | 11.63 | 95 | 28456 | 204580 | 34723800 |
| Diastolic dysfunction | 18.33 | 11.63 | 24 | 28527 | 6203 | 34922177 |
| Chylothorax | 18.16 | 11.63 | 10 | 28541 | 771 | 34927609 |
| Diabetes mellitus | 18.02 | 11.63 | 81 | 28470 | 46792 | 34881588 |
| Arrhythmia | 17.81 | 11.63 | 67 | 28484 | 35741 | 34892639 |
| Upper respiratory tract inflammation | 17.17 | 11.63 | 13 | 28538 | 1731 | 34926649 |
| Nodal arrhythmia | 17.07 | 11.63 | 10 | 28541 | 868 | 34927512 |
| Foetal exposure during pregnancy | 16.99 | 11.63 | 5 | 28546 | 38096 | 34890284 |
| Postrenal failure | 16.93 | 11.63 | 8 | 28543 | 447 | 34927933 |
| Anxiety | 16.79 | 11.63 | 35 | 28516 | 99393 | 34828987 |
| Left ventricle outflow tract obstruction | 16.63 | 11.63 | 6 | 28545 | 167 | 34928213 |
| Bradyarrhythmia | 16.59 | 11.63 | 14 | 28537 | 2177 | 34926203 |
| Blood creatinine increased | 16.33 | 11.63 | 133 | 28418 | 94843 | 34833537 |
| Treatment failure | 16.16 | 11.63 | 9 | 28542 | 46688 | 34881692 |
| Left ventricular hypertrophy | 16.14 | 11.63 | 26 | 28525 | 8104 | 34920276 |
| Drug-induced liver injury | 16.08 | 11.63 | 56 | 28495 | 28776 | 34899604 |
| Blood testosterone free increased | 16.03 | 11.63 | 4 | 28547 | 29 | 34928351 |
| Sprue-like enteropathy | 16.02 | 11.63 | 8 | 28543 | 505 | 34927875 |
| Gastric ulcer haemorrhage | 15.99 | 11.63 | 21 | 28530 | 5445 | 34922935 |
| Pneumonitis chemical | 15.96 | 11.63 | 6 | 28545 | 188 | 34928192 |
| Left ventricular dysfunction | 15.91 | 11.63 | 29 | 28522 | 9978 | 34918402 |
| Haemorrhage subcutaneous | 15.88 | 11.63 | 14 | 28537 | 2310 | 34926070 |
| Pericoronitis | 15.80 | 11.63 | 3 | 28548 | 4 | 34928376 |
| Drug hypersensitivity | 15.67 | 11.63 | 26 | 28525 | 80503 | 34847877 |
| Renal artery arteriosclerosis | 15.57 | 11.63 | 4 | 28547 | 33 | 34928347 |
| Product use in unapproved indication | 15.46 | 11.63 | 47 | 28504 | 117452 | 34810928 |
| Tender joint count increased | 15.42 | 11.63 | 6 | 28545 | 207 | 34928173 |
| Ejection fraction decreased | 15.14 | 11.63 | 42 | 28509 | 19112 | 34909268 |
| Gastric ulcer | 15.12 | 11.63 | 37 | 28514 | 15613 | 34912767 |
| Lens dislocation | 15.10 | 11.63 | 5 | 28546 | 107 | 34928273 |
| Hypertensive crisis | 14.73 | 11.63 | 26 | 28525 | 8725 | 34919655 |
| Aortic valve incompetence | 14.72 | 11.63 | 21 | 28530 | 5883 | 34922497 |
| Gastric cancer | 14.67 | 11.63 | 22 | 28529 | 6447 | 34921933 |
| Cerebral haemorrhage | 14.67 | 11.63 | 62 | 28489 | 34875 | 34893505 |
| Tubulointerstitial nephritis | 14.59 | 11.63 | 44 | 28507 | 20980 | 34907400 |
| Bulbar palsy | 14.51 | 11.63 | 6 | 28545 | 243 | 34928137 |
| Decreased appetite | 14.44 | 11.63 | 203 | 28348 | 166189 | 34762191 |
| Blindness transient | 14.39 | 11.63 | 13 | 28538 | 2213 | 34926167 |
| Cardiomegaly | 14.39 | 11.63 | 36 | 28515 | 15402 | 34912978 |
| Neuropathy peripheral | 14.32 | 11.63 | 29 | 28522 | 83234 | 34845146 |
| Hypocalcaemia | 14.27 | 11.63 | 48 | 28503 | 24241 | 34904139 |
| Haemorrhagic transformation stroke | 14.22 | 11.63 | 11 | 28540 | 1512 | 34926868 |
| Coronary artery stenosis | 14.20 | 11.63 | 27 | 28524 | 9589 | 34918791 |
| Swollen joint count increased | 14.17 | 11.63 | 6 | 28545 | 258 | 34928122 |
| Blood pressure systolic increased | 14.05 | 11.63 | 46 | 28505 | 22906 | 34905474 |
| Systolic dysfunction | 14.05 | 11.63 | 14 | 28537 | 2694 | 34925686 |
| Prostatism | 14 | 11.63 | 6 | 28545 | 266 | 34928114 |
| Progesterone increased | 13.94 | 11.63 | 3 | 28548 | 10 | 34928370 |
| Pharyngitis | 13.89 | 11.63 | 24 | 28527 | 7920 | 34920460 |
| Pemphigoid | 13.63 | 11.63 | 25 | 28526 | 8641 | 34919739 |
| Blood cholinesterase decreased | 13.57 | 11.63 | 5 | 28546 | 148 | 34928232 |
| Sinus node dysfunction | 13.49 | 11.63 | 17 | 28534 | 4232 | 34924148 |
| Blood thyroid stimulating hormone increased | 13.47 | 11.63 | 17 | 28534 | 4238 | 34924142 |
| Ventricular tachycardia | 13.44 | 11.63 | 50 | 28501 | 26529 | 34901851 |
| Hospitalisation | 13.43 | 11.63 | 16 | 28535 | 56886 | 34871494 |
| Dissociation | 13.40 | 11.63 | 11 | 28540 | 1647 | 34926733 |
| Hepatitis acute | 13.34 | 11.63 | 23 | 28528 | 7578 | 34920802 |
| Calculus bladder | 13.32 | 11.63 | 9 | 28542 | 1003 | 34927377 |
| Febrile neutropenia | 13.28 | 11.63 | 62 | 28489 | 136787 | 34791593 |
| Target skin lesion | 13.14 | 11.63 | 3 | 28548 | 14 | 34928366 |
| Congenital brain damage | 12.97 | 11.63 | 3 | 28548 | 15 | 34928365 |
| Jaundice | 12.94 | 11.63 | 56 | 28495 | 31826 | 34896554 |
| Diverticulum intestinal haemorrhagic | 12.93 | 11.63 | 13 | 28538 | 2529 | 34925851 |
| Alkalosis hypochloraemic | 12.85 | 11.63 | 6 | 28545 | 326 | 34928054 |
| Vitamin B12 deficiency | 12.59 | 11.63 | 16 | 28535 | 4015 | 34924365 |
| Acute myocardial infarction | 12.56 | 11.63 | 81 | 28470 | 53638 | 34874742 |
| Dizziness | 12.48 | 11.63 | 249 | 28302 | 218272 | 34710108 |
| Colon cancer | 12.48 | 11.63 | 24 | 28527 | 8597 | 34919783 |
| Trigemino-cardiac reflex | 12.44 | 11.63 | 5 | 28546 | 188 | 34928192 |
| Electrocardiogram QRS complex shortened | 12.44 | 11.63 | 5 | 28546 | 188 | 34928192 |
| Hypertonic bladder | 12.28 | 11.63 | 11 | 28540 | 1853 | 34926527 |
| Blood pressure abnormal | 12.27 | 11.63 | 23 | 28528 | 8083 | 34920297 |
| Choroidal haemorrhage | 12.24 | 11.63 | 4 | 28547 | 82 | 34928298 |
| Angiopathy | 12.15 | 11.63 | 16 | 28535 | 4157 | 34924223 |
| Bradycardia | 12.10 | 11.63 | 104 | 28447 | 75314 | 34853066 |
| Melaena | 12.03 | 11.63 | 59 | 28492 | 35321 | 34893059 |
| Coronary artery disease | 12.02 | 11.63 | 74 | 28477 | 48231 | 34880149 |
| Ocular pemphigoid | 11.85 | 11.63 | 4 | 28547 | 91 | 34928289 |
| Transient aphasia | 11.72 | 11.63 | 6 | 28545 | 399 | 34927981 |
| Agitation | 11.67 | 11.63 | 18 | 28533 | 57381 | 34870999 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cerebral infarction | 153.84 | 10.19 | 184 | 62043 | 45492 | 79636669 |
| Hyponatraemia | 151.22 | 10.19 | 389 | 61838 | 177459 | 79504702 |
| Completed suicide | 118.13 | 10.19 | 24 | 62203 | 245743 | 79436418 |
| Blood pressure increased | 114.46 | 10.19 | 394 | 61833 | 210966 | 79471195 |
| Hepatic function abnormal | 91.01 | 10.19 | 186 | 62041 | 72921 | 79609240 |
| Death | 85.52 | 10.19 | 198 | 62029 | 566316 | 79115845 |
| Altered state of consciousness | 83.29 | 10.19 | 134 | 62093 | 43688 | 79638473 |
| Interstitial lung disease | 83.24 | 10.19 | 234 | 61993 | 112366 | 79569795 |
| Hypertensive crisis | 82.26 | 10.19 | 91 | 62136 | 20679 | 79661482 |
| Hyperkalaemia | 80.94 | 10.19 | 234 | 61993 | 114164 | 79567997 |
| Acute kidney injury | 76.74 | 10.19 | 678 | 61549 | 518726 | 79163435 |
| Bradycardia | 75.34 | 10.19 | 255 | 61972 | 135302 | 79546859 |
| Chronic kidney disease | 74.99 | 10.19 | 162 | 62065 | 65992 | 79616169 |
| Cardiac failure | 73.01 | 10.19 | 276 | 61951 | 154566 | 79527595 |
| Blood pressure systolic increased | 72.49 | 10.19 | 161 | 62066 | 66825 | 79615336 |
| Renal impairment | 70.10 | 10.19 | 276 | 61951 | 157507 | 79524654 |
| Hypoglycaemia | 69.17 | 10.19 | 205 | 62022 | 101389 | 79580772 |
| Lactic acidosis | 66.13 | 10.19 | 160 | 62067 | 70199 | 79611962 |
| Off label use | 65.70 | 10.19 | 427 | 61800 | 906788 | 78775373 |
| Pulmonary valve disease | 59.93 | 10.19 | 18 | 62209 | 290 | 79681871 |
| Blood pressure decreased | 58.71 | 10.19 | 191 | 62036 | 99275 | 79582886 |
| Maternal exposure during pregnancy | 56.60 | 10.19 | 18 | 62209 | 136520 | 79545641 |
| Pericardial disease | 55.99 | 10.19 | 20 | 62207 | 567 | 79681594 |
| Endometriosis | 55.50 | 10.19 | 35 | 62192 | 3633 | 79678528 |
| Diabetic nephropathy | 54.56 | 10.19 | 32 | 62195 | 2915 | 79679246 |
| Product dose omission issue | 54.29 | 10.19 | 68 | 62159 | 247469 | 79434692 |
| Labile hypertension | 53.48 | 10.19 | 19 | 62208 | 530 | 79681631 |
| Blood creatine phosphokinase increased | 51.45 | 10.19 | 140 | 62087 | 65950 | 79616211 |
| Alopecia | 50.27 | 10.19 | 64 | 62163 | 231291 | 79450870 |
| Pemphigus | 49.34 | 10.19 | 9 | 62218 | 99573 | 79582588 |
| Carcinoid tumour pulmonary | 47.95 | 10.19 | 16 | 62211 | 368 | 79681793 |
| Physical examination abnormal | 47.20 | 10.19 | 15 | 62212 | 294 | 79681867 |
| Glaucoma | 46.87 | 10.19 | 67 | 62160 | 19694 | 79662467 |
| Isosthenuria | 46.04 | 10.19 | 12 | 62215 | 111 | 79682050 |
| Product packaging confusion | 45.64 | 10.19 | 14 | 62213 | 243 | 79681918 |
| Hemiplegia | 45.14 | 10.19 | 57 | 62170 | 14882 | 79667279 |
| Anti-cyclic citrullinated peptide antibody positive | 44.62 | 10.19 | 6 | 62221 | 83137 | 79599024 |
| Fall | 44.04 | 10.19 | 577 | 61650 | 487052 | 79195109 |
| Rhabdomyolysis | 43.85 | 10.19 | 178 | 62049 | 102953 | 79579208 |
| Drug specific antibody | 42.09 | 10.19 | 26 | 62201 | 2602 | 79679559 |
| Listless | 41.97 | 10.19 | 30 | 62197 | 3831 | 79678330 |
| Carotid arteriosclerosis | 41.84 | 10.19 | 26 | 62201 | 2630 | 79679531 |
| Head discomfort | 41.72 | 10.19 | 54 | 62173 | 14448 | 79667713 |
| Drug eruption | 40.30 | 10.19 | 99 | 62128 | 43836 | 79638325 |
| Toxicity to various agents | 39.99 | 10.19 | 181 | 62046 | 421359 | 79260802 |
| Neutropenia | 39.83 | 10.19 | 105 | 62122 | 287605 | 79394556 |
| Pain | 39.60 | 10.19 | 355 | 61872 | 703447 | 78978714 |
| Drug ineffective | 38.57 | 10.19 | 603 | 61624 | 1080310 | 78601851 |
| Growth hormone deficiency | 38.54 | 10.19 | 14 | 62213 | 417 | 79681744 |
| Arthritis | 38.03 | 10.19 | 184 | 62043 | 114696 | 79567465 |
| Pericarditis | 36.22 | 10.19 | 18 | 62209 | 104218 | 79577943 |
| Infusion site streaking | 35.77 | 10.19 | 14 | 62213 | 514 | 79681647 |
| Glossodynia | 35.68 | 10.19 | 18 | 62209 | 103319 | 79578842 |
| Oliguria | 35.35 | 10.19 | 53 | 62174 | 16256 | 79665905 |
| Abdominal discomfort | 35.08 | 10.19 | 91 | 62136 | 250636 | 79431525 |
| Postprandial hypoglycaemia | 35.05 | 10.19 | 9 | 62218 | 78 | 79682083 |
| Platelet distribution width increased | 34.93 | 10.19 | 10 | 62217 | 135 | 79682026 |
| Product use in unapproved indication | 34.93 | 10.19 | 91 | 62136 | 250268 | 79431893 |
| Electrocardiogram PR shortened | 34.90 | 10.19 | 12 | 62215 | 303 | 79681858 |
| Irritable bowel syndrome | 34.60 | 10.19 | 4 | 62223 | 62237 | 79619924 |
| Creatinine renal clearance increased | 34.50 | 10.19 | 16 | 62211 | 897 | 79681264 |
| Affect lability | 34.08 | 10.19 | 43 | 62184 | 11216 | 79670945 |
| Pyelitis | 33.90 | 10.19 | 12 | 62215 | 331 | 79681830 |
| Blood creatinine increased | 33.82 | 10.19 | 222 | 62005 | 154835 | 79527326 |
| Administration site abscess | 33.66 | 10.19 | 7 | 62220 | 20 | 79682141 |
| Infection | 33.61 | 10.19 | 88 | 62139 | 241624 | 79440537 |
| Electrocardiogram Q wave abnormal | 33.38 | 10.19 | 14 | 62213 | 616 | 79681545 |
| Hypertension | 32.97 | 10.19 | 399 | 61828 | 330593 | 79351568 |
| Dyslalia | 32.06 | 10.19 | 16 | 62211 | 1056 | 79681105 |
| Breath sounds abnormal | 31.91 | 10.19 | 50 | 62177 | 15934 | 79666227 |
| Administration site discharge | 31.85 | 10.19 | 7 | 62220 | 28 | 79682133 |
| Carotid artery thrombosis | 31.54 | 10.19 | 23 | 62204 | 3030 | 79679131 |
| Administration site induration | 31.28 | 10.19 | 7 | 62220 | 31 | 79682130 |
| Reduced facial expression | 31.25 | 10.19 | 22 | 62205 | 2743 | 79679418 |
| Liver disorder | 30.79 | 10.19 | 125 | 62102 | 72292 | 79609869 |
| Blood pressure abnormal | 30.58 | 10.19 | 51 | 62176 | 17118 | 79665043 |
| Administration site odour | 30.42 | 10.19 | 7 | 62220 | 36 | 79682125 |
| Neurologic neglect syndrome | 30.26 | 10.19 | 22 | 62205 | 2885 | 79679276 |
| Haematuria | 30.21 | 10.19 | 120 | 62107 | 68716 | 79613445 |
| Exposure during pregnancy | 30.14 | 10.19 | 21 | 62206 | 101111 | 79581050 |
| Sleep apnoea syndrome | 30.13 | 10.19 | 79 | 62148 | 36399 | 79645762 |
| Hepatojugular reflux | 29.72 | 10.19 | 13 | 62214 | 635 | 79681526 |
| Pemphigoid | 29.32 | 10.19 | 47 | 62180 | 15268 | 79666893 |
| Inappropriate antidiuretic hormone secretion | 29.31 | 10.19 | 64 | 62163 | 26249 | 79655912 |
| Fatigue | 29.08 | 10.19 | 531 | 61696 | 929196 | 78752965 |
| Cerebral haemorrhage | 28.99 | 10.19 | 105 | 62122 | 57568 | 79624593 |
| Atrial fibrillation | 28.42 | 10.19 | 257 | 61970 | 197629 | 79484532 |
| Disease progression | 28.08 | 10.19 | 64 | 62163 | 184298 | 79497863 |
| Systemic lupus erythematosus | 27.90 | 10.19 | 32 | 62195 | 121117 | 79561044 |
| Loss of consciousness | 27.74 | 10.19 | 225 | 62002 | 167718 | 79514443 |
| Myalgia | 27.64 | 10.19 | 243 | 61984 | 185398 | 79496763 |
| Folliculitis | 27.44 | 10.19 | 5 | 62222 | 55375 | 79626786 |
| Blood thyroid stimulating hormone normal | 27.35 | 10.19 | 8 | 62219 | 117 | 79682044 |
| C-reactive protein abnormal | 27.16 | 10.19 | 3 | 62224 | 48364 | 79633797 |
| Stenosis | 26.74 | 10.19 | 19 | 62208 | 2403 | 79679758 |
| Arterial occlusive disease | 26.72 | 10.19 | 33 | 62194 | 8423 | 79673738 |
| Administration site haemorrhage | 26.55 | 10.19 | 7 | 62220 | 68 | 79682093 |
| Atrioventricular block complete | 26.52 | 10.19 | 47 | 62180 | 16563 | 79665598 |
| Impaired healing | 26.39 | 10.19 | 18 | 62209 | 87637 | 79594524 |
| Bladder hypertrophy | 26.32 | 10.19 | 12 | 62215 | 647 | 79681514 |
| Diabetes mellitus | 26.25 | 10.19 | 126 | 62101 | 78264 | 79603897 |
| Blood pressure inadequately controlled | 26.09 | 10.19 | 28 | 62199 | 6149 | 79676012 |
| Drug abuse | 25.99 | 10.19 | 55 | 62172 | 162636 | 79519525 |
| White blood cell count abnormal | 25.97 | 10.19 | 27 | 62200 | 5718 | 79676443 |
| Swelling | 25.69 | 10.19 | 85 | 62142 | 216626 | 79465535 |
| Hand deformity | 25.54 | 10.19 | 26 | 62201 | 103893 | 79578268 |
| Endophthalmitis | 25.17 | 10.19 | 28 | 62199 | 6400 | 79675761 |
| Staphylococcus test positive | 24.98 | 10.19 | 28 | 62199 | 6453 | 79675708 |
| Muscle injury | 24.91 | 10.19 | 4 | 62223 | 48557 | 79633604 |
| Therapeutic product effect decreased | 24.86 | 10.19 | 57 | 62170 | 163806 | 79518355 |
| Injection site cyst | 24.69 | 10.19 | 7 | 62220 | 91 | 79682070 |
| Hypersensitivity | 24.60 | 10.19 | 113 | 62114 | 262126 | 79420035 |
| IgA nephropathy | 24.59 | 10.19 | 16 | 62211 | 1752 | 79680409 |
| Haemoglobin increased | 24.51 | 10.19 | 27 | 62200 | 6105 | 79676056 |
| Narrow anterior chamber angle | 24.39 | 10.19 | 8 | 62219 | 174 | 79681987 |
| Bundle branch block left | 24.36 | 10.19 | 37 | 62190 | 11476 | 79670685 |
| Haemorrhage subcutaneous | 24.29 | 10.19 | 24 | 62203 | 4785 | 79677376 |
| Hypertensive angiopathy | 24.02 | 10.19 | 7 | 62220 | 101 | 79682060 |
| Drug interaction | 23.99 | 10.19 | 456 | 61771 | 414727 | 79267434 |
| Labelled drug-drug interaction medication error | 23.99 | 10.19 | 61 | 62166 | 27589 | 79654572 |
| Arrhythmia | 23.88 | 10.19 | 103 | 62124 | 61169 | 79620992 |
| Cardiac discomfort | 23.88 | 10.19 | 14 | 62213 | 1274 | 79680887 |
| Febrile neutropenia | 23.83 | 10.19 | 96 | 62131 | 230903 | 79451258 |
| Gastric pH increased | 23.37 | 10.19 | 6 | 62221 | 52 | 79682109 |
| Tender joint count | 23.31 | 10.19 | 8 | 62219 | 201 | 79681960 |
| Granuloma skin | 23.08 | 10.19 | 32 | 62195 | 9142 | 79673019 |
| Accident at work | 22.81 | 10.19 | 13 | 62214 | 1122 | 79681039 |
| Helicobacter infection | 22.80 | 10.19 | 13 | 62214 | 69691 | 79612470 |
| Urinary retention | 22.69 | 10.19 | 96 | 62131 | 56534 | 79625627 |
| Rales | 22.68 | 10.19 | 49 | 62178 | 19952 | 79662209 |
| Blood parathyroid hormone decreased | 22.49 | 10.19 | 34 | 62193 | 10502 | 79671659 |
| Apathy | 22.39 | 10.19 | 38 | 62189 | 12939 | 79669222 |
| Daydreaming | 22.36 | 10.19 | 12 | 62215 | 921 | 79681240 |
| Carbohydrate antigen 15-3 increased | 22.35 | 10.19 | 13 | 62214 | 1166 | 79680995 |
| Product monitoring error | 22.31 | 10.19 | 31 | 62196 | 8875 | 79673286 |
| Joint noise | 22.27 | 10.19 | 21 | 62206 | 3953 | 79678208 |
| Blood urea increased | 22.17 | 10.19 | 86 | 62141 | 48704 | 79633457 |
| Duodenal ulcer perforation | 22.16 | 10.19 | 12 | 62215 | 66199 | 79615962 |
| Bradyarrhythmia | 21.52 | 10.19 | 21 | 62206 | 4125 | 79678036 |
| Porphyrins urine increased | 21.22 | 10.19 | 5 | 62222 | 29 | 79682132 |
| Vertigo | 20.98 | 10.19 | 108 | 62119 | 68974 | 79613187 |
| Left ventricular hypertrophy | 20.95 | 10.19 | 34 | 62193 | 11157 | 79671004 |
| Menopausal symptoms | 20.76 | 10.19 | 15 | 62212 | 1948 | 79680213 |
| Buttock injury | 20.70 | 10.19 | 7 | 62220 | 168 | 79681993 |
| Cardiomegaly | 20.68 | 10.19 | 56 | 62171 | 26296 | 79655865 |
| Hypokalaemia | 20.64 | 10.19 | 187 | 62040 | 143853 | 79538308 |
| Drug resistance | 20.51 | 10.19 | 4 | 62223 | 42209 | 79639952 |
| Serotonin syndrome | 20.39 | 10.19 | 5 | 62222 | 45022 | 79637139 |
| Hyperaldosteronism | 20.36 | 10.19 | 9 | 62218 | 451 | 79681710 |
| Scoliosis | 20.24 | 10.19 | 27 | 62200 | 7437 | 79674724 |
| Acquired porphyria | 20.17 | 10.19 | 5 | 62222 | 37 | 79682124 |
| Hypotension | 20.03 | 10.19 | 467 | 61760 | 439850 | 79242311 |
| Arthropathy | 19.95 | 10.19 | 71 | 62156 | 177040 | 79505121 |
| Mitral valve incompetence | 19.77 | 10.19 | 58 | 62169 | 28507 | 79653654 |
| Carotid artery stenosis | 19.75 | 10.19 | 29 | 62198 | 8729 | 79673432 |
| Panniculitis | 19.74 | 10.19 | 35 | 62192 | 12336 | 79669825 |
| Ventricular arrhythmia | 19.55 | 10.19 | 29 | 62198 | 8811 | 79673350 |
| Porphyrins stool increased | 19.41 | 10.19 | 5 | 62222 | 44 | 79682117 |
| Agitation | 19.24 | 10.19 | 30 | 62197 | 99685 | 79582476 |
| Carcinoembryonic antigen increased | 19.18 | 10.19 | 15 | 62212 | 2194 | 79679967 |
| Dyspnoea at rest | 19.17 | 10.19 | 26 | 62201 | 7276 | 79674885 |
| Asthma | 19.16 | 10.19 | 175 | 62052 | 134920 | 79547241 |
| Product used for unknown indication | 19.13 | 10.19 | 13 | 62214 | 1531 | 79680630 |
| Hypoglycaemic coma | 19.10 | 10.19 | 21 | 62206 | 4739 | 79677422 |
| Renal artery restenosis | 19.09 | 10.19 | 4 | 62223 | 12 | 79682149 |
| Gastric ulcer haemorrhage | 19.09 | 10.19 | 29 | 62198 | 8998 | 79673163 |
| Syncope | 19.02 | 10.19 | 219 | 62008 | 179230 | 79502931 |
| Albuminuria | 18.98 | 10.19 | 10 | 62217 | 739 | 79681422 |
| Product substitution issue | 18.95 | 10.19 | 46 | 62181 | 20210 | 79661951 |
| Labile blood pressure | 18.92 | 10.19 | 15 | 62212 | 2238 | 79679923 |
| Dizziness | 18.88 | 10.19 | 541 | 61686 | 525900 | 79156261 |
| Osteocalcin decreased | 18.83 | 10.19 | 5 | 62222 | 50 | 79682111 |
| Staring | 18.83 | 10.19 | 16 | 62211 | 2629 | 79679532 |
| Psoriasis | 18.76 | 10.19 | 127 | 62100 | 89460 | 79592701 |
| Non-small cell lung cancer recurrent | 18.67 | 10.19 | 6 | 62221 | 122 | 79682039 |
| Sprue-like enteropathy | 18.51 | 10.19 | 12 | 62215 | 1306 | 79680855 |
| Ureteral disorder | 18.47 | 10.19 | 9 | 62218 | 564 | 79681597 |
| Drug-induced liver injury | 18.46 | 10.19 | 101 | 62126 | 66016 | 79616145 |
| Diverticulum intestinal haemorrhagic | 18.40 | 10.19 | 19 | 62208 | 3992 | 79678169 |
| Muscle atrophy | 18.21 | 10.19 | 32 | 62195 | 11200 | 79670961 |
| Renal tubular acidosis | 18.19 | 10.19 | 18 | 62209 | 3596 | 79678565 |
| Renal failure | 18.16 | 10.19 | 238 | 61989 | 200730 | 79481431 |
| Mitral valve disease | 18.12 | 10.19 | 17 | 62210 | 3180 | 79678981 |
| Prescription drug used without a prescription | 18.11 | 10.19 | 19 | 62208 | 4066 | 79678095 |
| Skin necrosis | 17.92 | 10.19 | 42 | 62185 | 18045 | 79664116 |
| Occult blood | 17.84 | 10.19 | 13 | 62214 | 1710 | 79680451 |
| Urine calcium/creatinine ratio increased | 17.82 | 10.19 | 6 | 62221 | 142 | 79682019 |
| Suicidal ideation | 17.75 | 10.19 | 20 | 62207 | 76320 | 79605841 |
| Bronchiolitis | 17.72 | 10.19 | 19 | 62208 | 4169 | 79677992 |
| Hypercalcaemia | 17.67 | 10.19 | 68 | 62159 | 38362 | 79643799 |
| Melaena | 17.66 | 10.19 | 94 | 62133 | 60796 | 79621365 |
| Drug ineffective for unapproved indication | 17.57 | 10.19 | 9 | 62218 | 51229 | 79630932 |
| Thalamus haemorrhage | 17.45 | 10.19 | 13 | 62214 | 1769 | 79680392 |
| Gouty arthritis | 17.39 | 10.19 | 12 | 62215 | 1449 | 79680712 |
| Fibromyalgia | 17.10 | 10.19 | 15 | 62212 | 64325 | 79617836 |
| Urethral caruncle | 17.04 | 10.19 | 5 | 62222 | 74 | 79682087 |
| Skin dystrophy | 17.04 | 10.19 | 5 | 62222 | 74 | 79682087 |
| Echocardiogram abnormal | 16.94 | 10.19 | 14 | 62213 | 2214 | 79679947 |
| Anaplastic astrocytoma | 16.94 | 10.19 | 6 | 62221 | 166 | 79681995 |
| Renal function test abnormal | 16.60 | 10.19 | 20 | 62207 | 4978 | 79677183 |
| Stomatitis | 16.42 | 10.19 | 59 | 62168 | 146698 | 79535463 |
| Mucosal inflammation | 16.30 | 10.19 | 21 | 62206 | 75559 | 79606602 |
| Treatment failure | 16.25 | 10.19 | 73 | 62154 | 170413 | 79511748 |
| Drug tolerance decreased | 16.11 | 10.19 | 33 | 62194 | 12945 | 79669216 |
| Neurotoxicity | 15.97 | 10.19 | 3 | 62224 | 32515 | 79649646 |
| Colon cancer | 15.81 | 10.19 | 35 | 62192 | 14488 | 79667673 |
| Helicobacter gastritis | 15.79 | 10.19 | 14 | 62213 | 2435 | 79679726 |
| Angina pectoris | 15.79 | 10.19 | 81 | 62146 | 51651 | 79630510 |
| Carcinoid tumour | 15.74 | 10.19 | 8 | 62219 | 549 | 79681612 |
| Rash | 15.70 | 10.19 | 338 | 61889 | 578020 | 79104141 |
| Face oedema | 15.67 | 10.19 | 53 | 62174 | 28083 | 79654078 |
| Foreign body | 15.66 | 10.19 | 15 | 62212 | 2879 | 79679282 |
| Tricuspid valve incompetence | 15.58 | 10.19 | 42 | 62185 | 19670 | 79662491 |
| Pulse abnormal | 15.47 | 10.19 | 16 | 62211 | 3368 | 79678793 |
| Insulin-like growth factor decreased | 15.37 | 10.19 | 8 | 62219 | 577 | 79681584 |
| Sinus congestion | 15.33 | 10.19 | 42 | 62185 | 19854 | 79662307 |
| Breast cancer recurrent | 15.30 | 10.19 | 15 | 62212 | 2962 | 79679199 |
| Toxic epidermal necrolysis | 15.17 | 10.19 | 72 | 62155 | 44509 | 79637652 |
| HLA-B*27 positive | 15.15 | 10.19 | 5 | 62222 | 111 | 79682050 |
| Gangrene | 15.13 | 10.19 | 26 | 62201 | 8938 | 79673223 |
| Hospitalisation | 14.92 | 10.19 | 32 | 62195 | 94204 | 79587957 |
| Upper respiratory tract inflammation | 14.82 | 10.19 | 17 | 62210 | 4018 | 79678143 |
| Personality disorder | 14.81 | 10.19 | 21 | 62206 | 6125 | 79676036 |
| Vascular purpura | 14.80 | 10.19 | 15 | 62212 | 3083 | 79679078 |
| Chronic gastritis | 14.70 | 10.19 | 17 | 62210 | 4051 | 79678110 |
| Cardiac failure chronic | 14.64 | 10.19 | 29 | 62198 | 11106 | 79671055 |
| Myocardial rupture | 14.64 | 10.19 | 6 | 62221 | 249 | 79681912 |
| Intentional product use issue | 14.58 | 10.19 | 65 | 62162 | 152047 | 79530114 |
| Cytokine release syndrome | 14.47 | 10.19 | 5 | 62222 | 35993 | 79646168 |
| Product use issue | 14.46 | 10.19 | 100 | 62127 | 209722 | 79472439 |
| Petit mal epilepsy | 14.44 | 10.19 | 20 | 62207 | 5707 | 79676454 |
| Coronary artery disease | 14.42 | 10.19 | 94 | 62133 | 65380 | 79616781 |
| Hyperlipidaemia | 14.40 | 10.19 | 49 | 62178 | 26044 | 79656117 |
| Neuropathy peripheral | 14.39 | 10.19 | 59 | 62168 | 141246 | 79540915 |
| Injection site bruising | 14.36 | 10.19 | 7 | 62220 | 40995 | 79641166 |
| Paralysis recurrent laryngeal nerve | 14.33 | 10.19 | 5 | 62222 | 132 | 79682029 |
| Blood pressure diastolic decreased | 14.33 | 10.19 | 54 | 62173 | 30162 | 79651999 |
| Renal artery arteriosclerosis | 14.33 | 10.19 | 4 | 62223 | 49 | 79682112 |
| Electrocardiogram PR prolongation | 14.29 | 10.19 | 11 | 62216 | 1572 | 79680589 |
| Postrenal failure | 14.27 | 10.19 | 8 | 62219 | 669 | 79681492 |
| Dementia | 14.22 | 10.19 | 47 | 62180 | 24612 | 79657549 |
| Bulbar palsy | 14.22 | 10.19 | 6 | 62221 | 268 | 79681893 |
| Drug level increased | 14.20 | 10.19 | 65 | 62162 | 39586 | 79642575 |
| Glycosylated haemoglobin increased | 14.19 | 10.19 | 40 | 62187 | 19220 | 79662941 |
| Nodal arrhythmia | 14.16 | 10.19 | 12 | 62215 | 1966 | 79680195 |
| Blood cholinesterase decreased | 14.08 | 10.19 | 6 | 62221 | 275 | 79681886 |
| Tender joint count increased | 14.05 | 10.19 | 6 | 62221 | 276 | 79681885 |
| Accelerated hypertension | 14.00 | 10.19 | 8 | 62219 | 694 | 79681467 |
| Blood pressure fluctuation | 13.94 | 10.19 | 95 | 62132 | 67050 | 79615111 |
| Clubbing | 13.86 | 10.19 | 8 | 62219 | 707 | 79681454 |
| Cystitis | 13.69 | 10.19 | 79 | 62148 | 52653 | 79629508 |
| Hypertensive nephropathy | 13.67 | 10.19 | 9 | 62218 | 1005 | 79681156 |
| Psoriatic arthropathy | 13.63 | 10.19 | 25 | 62202 | 77974 | 79604187 |
| Palpitations | 13.63 | 10.19 | 155 | 62072 | 126455 | 79555706 |
| Blood potassium increased | 13.62 | 10.19 | 52 | 62175 | 29223 | 79652938 |
| Lens dislocation | 13.58 | 10.19 | 5 | 62222 | 155 | 79682006 |
| Hyperuricaemia | 13.48 | 10.19 | 29 | 62198 | 11770 | 79670391 |
| Hypokinesia | 13.47 | 10.19 | 39 | 62188 | 19021 | 79663140 |
| Wound | 13.47 | 10.19 | 46 | 62181 | 116133 | 79566028 |
| Calculus bladder | 13.42 | 10.19 | 10 | 62217 | 1362 | 79680799 |
| Drug hypersensitivity | 13.37 | 10.19 | 159 | 62068 | 298757 | 79383404 |
| Anaemia macrocytic | 13.30 | 10.19 | 19 | 62208 | 5578 | 79676583 |
| Acute myocardial infarction | 13.14 | 10.19 | 104 | 62123 | 76932 | 79605229 |
| Memory impairment | 13.11 | 10.19 | 44 | 62183 | 111690 | 79570471 |
| Dehydration | 13.10 | 10.19 | 269 | 61958 | 247918 | 79434243 |
| Bite | 13.04 | 10.19 | 7 | 62220 | 537 | 79681624 |
| Hypersensitivity vasculitis | 12.87 | 10.19 | 21 | 62206 | 6922 | 79675239 |
| Respiratory distress | 12.80 | 10.19 | 16 | 62211 | 58323 | 79623838 |
| Drug intolerance | 12.79 | 10.19 | 138 | 62089 | 263981 | 79418180 |
| Aortic dissection | 12.72 | 10.19 | 16 | 62211 | 4159 | 79678002 |
| Peripheral arterial occlusive disease | 12.71 | 10.19 | 23 | 62204 | 8235 | 79673926 |
| Delirium | 12.70 | 10.19 | 111 | 62116 | 84516 | 79597645 |
| Pancreatitis acute | 12.67 | 10.19 | 74 | 62153 | 49530 | 79632631 |
| Respiratory depression | 12.65 | 10.19 | 3 | 62224 | 27627 | 79654534 |
| Sinusitis | 12.59 | 10.19 | 95 | 62132 | 195406 | 79486755 |
| C-reactive protein increased | 12.58 | 10.19 | 155 | 62072 | 128872 | 79553289 |
| Tubulointerstitial nephritis | 12.47 | 10.19 | 61 | 62166 | 38174 | 79643987 |
| Retinal infarction | 12.35 | 10.19 | 5 | 62222 | 201 | 79681960 |
| Gamma-glutamyltransferase increased | 12.34 | 10.19 | 79 | 62148 | 54601 | 79627560 |
| Injection site paraesthesia | 12.31 | 10.19 | 7 | 62220 | 602 | 79681559 |
| Leukopenia | 12.27 | 10.19 | 48 | 62179 | 116465 | 79565696 |
| Multiple sclerosis relapse | 12.18 | 10.19 | 11 | 62216 | 46522 | 79635639 |
| Mental status changes | 12.12 | 10.19 | 21 | 62206 | 66938 | 79615223 |
| Liver injury | 11.93 | 10.19 | 16 | 62211 | 56598 | 79625563 |
| Knee deformity | 11.75 | 10.19 | 9 | 62218 | 1276 | 79680885 |
| Basal cell carcinoma | 11.74 | 10.19 | 59 | 62168 | 37316 | 79644845 |
| Diastolic dysfunction | 11.70 | 10.19 | 26 | 62201 | 10785 | 79671376 |
| Gastric cancer | 11.61 | 10.19 | 25 | 62202 | 10154 | 79672007 |
| Oropharyngeal oedema | 11.43 | 10.19 | 6 | 62221 | 440 | 79681721 |
| Rheumatic fever | 11.40 | 10.19 | 4 | 62223 | 28521 | 79653640 |
| Jaundice | 11.39 | 10.19 | 76 | 62151 | 53273 | 79628888 |
| Orthostatic hypotension | 11.38 | 10.19 | 79 | 62148 | 56085 | 79626076 |
| Lower respiratory tract infection | 11.34 | 10.19 | 57 | 62170 | 129163 | 79552998 |
| Haemophilia | 11.31 | 10.19 | 4 | 62223 | 110 | 79682051 |
| Bile duct cancer | 11.23 | 10.19 | 8 | 62219 | 1016 | 79681145 |
| Sinus arrest | 11.23 | 10.19 | 14 | 62213 | 3608 | 79678553 |
| Joint range of motion decreased | 11.18 | 10.19 | 6 | 62221 | 33276 | 79648885 |
| Guttate psoriasis | 11.17 | 10.19 | 6 | 62221 | 461 | 79681700 |
| Thyroid disorder | 11.13 | 10.19 | 30 | 62197 | 14049 | 79668112 |
| Pneumonitis chemical | 11.11 | 10.19 | 6 | 62221 | 466 | 79681695 |
| Trigemino-cardiac reflex | 11.06 | 10.19 | 5 | 62222 | 264 | 79681897 |
| Transient aphasia | 11.02 | 10.19 | 6 | 62221 | 474 | 79681687 |
| Porphyria non-acute | 10.97 | 10.19 | 7 | 62220 | 742 | 79681419 |
| Depressed mood | 10.95 | 10.19 | 13 | 62214 | 48467 | 79633694 |
| Hyperglycaemia | 10.94 | 10.19 | 93 | 62134 | 70242 | 79611919 |
| Coordination abnormal | 10.89 | 10.19 | 34 | 62193 | 17278 | 79664883 |
| Spinal epidural haematoma | 10.89 | 10.19 | 9 | 62218 | 1423 | 79680738 |
| Alkalosis hypochloraemic | 10.74 | 10.19 | 6 | 62221 | 498 | 79681663 |
| Muscle twitching | 10.74 | 10.19 | 3 | 62224 | 24761 | 79657400 |
| Systolic dysfunction | 10.71 | 10.19 | 14 | 62213 | 3781 | 79678380 |
| Gastrointestinal disorder | 10.67 | 10.19 | 54 | 62173 | 122151 | 79560010 |
| Pelvic fracture | 10.66 | 10.19 | 27 | 62200 | 12177 | 79669984 |
| Blood pressure diastolic abnormal | 10.54 | 10.19 | 36 | 62191 | 19166 | 79662995 |
| Hyperplasia adrenal | 10.51 | 10.19 | 3 | 62224 | 40 | 79682121 |
| Erythema multiforme | 10.50 | 10.19 | 34 | 62193 | 17617 | 79664544 |
| Device issue | 10.49 | 10.19 | 4 | 62223 | 27104 | 79655057 |
| Bile duct stone | 10.49 | 10.19 | 17 | 62210 | 5572 | 79676589 |
| Neutropenic sepsis | 10.47 | 10.19 | 4 | 62223 | 27060 | 79655101 |
| Unevaluable event | 10.46 | 10.19 | 17 | 62210 | 55568 | 79626593 |
| COVID-19 | 10.44 | 10.19 | 76 | 62151 | 157598 | 79524563 |
| Knee arthroplasty | 10.42 | 10.19 | 11 | 62216 | 43237 | 79638924 |
| Aortic valve incompetence | 10.41 | 10.19 | 23 | 62204 | 9507 | 79672654 |
| Diabetes mellitus inadequate control | 10.40 | 10.19 | 42 | 62185 | 24222 | 79657939 |
| Abortion spontaneous | 10.39 | 10.19 | 5 | 62222 | 29502 | 79652659 |
| Immobilisation syndrome | 10.38 | 10.19 | 6 | 62221 | 532 | 79681629 |
| Dihydrotestosterone increased | 10.38 | 10.19 | 3 | 62224 | 42 | 79682119 |
| Anaemia | 10.32 | 10.19 | 435 | 61792 | 444580 | 79237581 |
| Glomerular filtration rate decreased | 10.30 | 10.19 | 40 | 62187 | 22662 | 79659499 |
| Coronary artery stenosis | 10.27 | 10.19 | 27 | 62200 | 12457 | 79669704 |
| Platelet count decreased | 10.27 | 10.19 | 211 | 62016 | 194453 | 79487708 |
| Hypercreatinaemia | 10.26 | 10.19 | 5 | 62222 | 313 | 79681848 |
| Cerebellar haemorrhage | 10.22 | 10.19 | 12 | 62215 | 2908 | 79679253 |
| Immobile | 10.20 | 10.19 | 19 | 62208 | 6954 | 79675207 |
FDA Adverse Event Reporting System (Pediatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Renal vein thrombosis | 23.65 | 20.13 | 3 | 11 | 0 | 89778 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C09CA07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN Angiotensin II receptor blockers (ARBs), plain |
| ATC | C09DA07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and diuretics |
| ATC | C09DB04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
| ATC | C09DX08 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
| FDA MoA | N0000000070 | Angiotensin 2 Receptor Antagonists |
| FDA EPC | N0000175561 | Angiotensin 2 Receptor Blocker |
| MeSH PA | D047228 | Angiotensin II Type 1 Receptor Blockers |
| MeSH PA | D057911 | Angiotensin Receptor Antagonists |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| CHEBI has role | CHEBI:35457 | ACE inhibitor |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:61016 | angiotensin receptor antagonists |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
| Cerebrovascular accident | indication | 230690007 | |
| Disorder due to type 2 diabetes mellitus | indication | 422014003 | |
| History of myocardial infarction due to atherothrombotic coronary artery disease | indication | 387786000000000000 | |
| Myocardial Infarction Prevention | indication | ||
| Chronic heart failure | off-label use | 48447003 | |
| Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
| Diabetic renal disease | off-label use | 127013003 | |
| Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
| Nondiabetic Proteinuric Nephropathy | off-label use | ||
| Anuria | contraindication | 2472002 | DOID:2983 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Hyperkalemia | contraindication | 14140009 | |
| Secondary angle-closure glaucoma | contraindication | 21571006 | |
| Hypovolemia | contraindication | 28560003 | |
| Obstruction of bile duct | contraindication | 30144000 | |
| Cholestasis | contraindication | 33688009 | DOID:13580 |
| Dehydration | contraindication | 34095006 | |
| Hyperuricemia | contraindication | 35885006 | DOID:1920 |
| Third trimester pregnancy | contraindication | 41587001 | |
| Severe renal impairment | contraindication | 42399005 | DOID:1074 |
| Hypokalemia | contraindication | 43339004 | |
| Low blood pressure | contraindication | 45007003 | |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Sympathectomy | contraindication | 57071006 | |
| Second trimester pregnancy | contraindication | 59466002 | |
| Hepatic failure | contraindication | 59927004 | |
| Severe hepatic impairment | contraindication | 59927004 | |
| Hypercalcemia | contraindication | 66931009 | DOID:12678 |
| Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
| Hypochloremic alkalosis | contraindication | 70134007 | |
| Hepatic coma | contraindication | 72836002 | DOID:12550 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Hyponatremia | contraindication | 89627008 | |
| Gout | contraindication | 90560007 | DOID:13189 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Hypomagnesemia | contraindication | 190855004 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Neonatal hyperbilirubinemia | contraindication | 281610001 | |
| Pregnancy, function | contraindication | 289908002 | |
| Renal artery stenosis | contraindication | 302233006 | |
| Azotemia | contraindication | 445009001 | |
| Severe Aortic Valve Stenosis | contraindication |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Systemic hypertension | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Semintra | Boehringer lngelheim Animal Health USA Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.65 | acidic |
| pKa2 | 5.79 | Basic |
| pKa3 | 5.13 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor | GPCR | ANTAGONIST | IC50 | 9.31 | CHEMBL | CHEMBL | |||
| ATP-binding cassette sub-family G member 2 | Transporter | IC50 | 4.77 | CHEMBL | |||||
| Glycine receptor subunit alpha-1 | Ion channel | EC50 | 5.49 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | EC50 | 5.82 | CHEMBL | |||||
| Type-2 angiotensin II receptor | GPCR | IC50 | 9.48 | CHEMBL | |||||
| Angiotensin-converting enzyme | Enzyme | Ki | 5.22 | CHEMBL | |||||
| Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 4.75 | CHEMBL | |||||
| Type-1B angiotensin II receptor | GPCR | IC50 | 8.52 | CHEMBL | |||||
| Type-1A angiotensin II receptor | GPCR | Ki | 9.64 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021146 | VUID |
| N0000148599 | NUI |
| D00627 | KEGG_DRUG |
| 4021146 | VANDF |
| C0248719 | UMLSCUI |
| CHEBI:9434 | CHEBI |
| TLS | PDB_CHEM_ID |
| CHEMBL1017 | ChEMBL_ID |
| D000077333 | MESH_DESCRIPTOR_UI |
| DB00966 | DRUGBANK_ID |
| 592 | IUPHAR_LIGAND_ID |
| 7144 | INN_ID |
| U5SYW473RQ | UNII |
| 65999 | PUBCHEM_CID |
| 218353 | RXNORM |
| 13913 | MMSL |
| 53287 | MMSL |
| 7789 | MMSL |
| d04364 | MMSL |
| 007683 | NDDF |
| 129487008 | SNOMEDCT_US |
| 387069000 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| telmisartan and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0545 | TABLET | 40 mg | ORAL | NDA authorized generic | 27 sections |
| telmisartan and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0546 | TABLET | 80 mg | ORAL | NDA authorized generic | 27 sections |
| telmisartan and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0054-0547 | TABLET | 80 mg | ORAL | NDA authorized generic | 27 sections |
| Telmisartan and Amlodipine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1075 | TABLET | 40 mg | ORAL | ANDA | 28 sections |
| Telmisartan and Amlodipine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1076 | TABLET | 40 mg | ORAL | ANDA | 28 sections |
| Telmisartan and Amlodipine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1077 | TABLET | 80 mg | ORAL | ANDA | 28 sections |
| Telmisartan and Amlodipine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-1078 | TABLET | 80 mg | ORAL | ANDA | 28 sections |
| Telmisartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2920 | TABLET | 20 mg | ORAL | ANDA | 28 sections |
| Telmisartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2920 | TABLET | 20 mg | ORAL | ANDA | 28 sections |
| Telmisartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2921 | TABLET | 40 mg | ORAL | ANDA | 28 sections |
| Telmisartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2921 | TABLET | 40 mg | ORAL | ANDA | 28 sections |
| Telmisartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2922 | TABLET | 80 mg | ORAL | ANDA | 28 sections |
| Telmisartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2922 | TABLET | 80 mg | ORAL | ANDA | 28 sections |
| Micardis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0039 | TABLET | 20 mg | ORAL | NDA | 26 sections |
| Micardis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0039 | TABLET | 20 mg | ORAL | NDA | 26 sections |
| Micardis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0040 | TABLET | 40 mg | ORAL | NDA | 26 sections |
| Micardis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0040 | TABLET | 40 mg | ORAL | NDA | 26 sections |
| Micardis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0041 | TABLET | 80 mg | ORAL | NDA | 26 sections |
| Micardis | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0041 | TABLET | 80 mg | ORAL | NDA | 26 sections |
| Micardis HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0597-0042 | TABLET | 80 mg | ORAL | NDA | 30 sections |
| Micardis HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0597-0042 | TABLET | 80 mg | ORAL | NDA | 30 sections |
| Micardis HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0597-0043 | TABLET | 40 mg | ORAL | NDA | 30 sections |
| Micardis HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0597-0043 | TABLET | 40 mg | ORAL | NDA | 30 sections |
| Micardis HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0597-0044 | TABLET | 80 mg | ORAL | NDA | 30 sections |
| Micardis HCT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0597-0044 | TABLET | 80 mg | ORAL | NDA | 30 sections |
| Telmisartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5372 | TABLET | 20 mg | ORAL | ANDA | 26 sections |
| Telmisartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5374 | TABLET | 40 mg | ORAL | ANDA | 26 sections |
| Telmisartan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5378 | TABLET | 80 mg | ORAL | ANDA | 26 sections |
| TELMISARTAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-156 | TABLET | 20 mg | ORAL | ANDA | 18 sections |
| TELMISARTAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-156 | TABLET | 20 mg | ORAL | ANDA | 18 sections |