nifedipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 1922 21829-25-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BAY A1040
  • nifedipine
  • nedipin
  • fedipin
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
  • Molecular weight: 346.34
  • Formula: C17H18N2O6
  • CLOGP: 3.12
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 110.45
  • ALOGS: -4.29
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.01 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 3.71 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.79 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.04 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1981 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 534.83 10.03 342 59389 26718 56205618
Exposure during pregnancy 296.28 10.03 524 59207 135818 56096518
Premature baby 259.29 10.03 192 59539 19013 56213323
Pre-eclampsia 184.48 10.03 114 59617 8372 56223964
Low birth weight baby 172.51 10.03 98 59633 6160 56226176
Foetal exposure during pregnancy 161.07 10.03 189 59542 33634 56198702
Pemphigus 128.88 10.03 10 59721 157202 56075134
Alopecia 125.87 10.03 78 59653 293380 55938956
Hypertension 119.18 10.03 544 59187 243734 55988602
Glossodynia 113.70 10.03 14 59717 152444 56079892
Blood pressure inadequately controlled 109.20 10.03 65 59666 4459 56227877
Premature labour 97.59 10.03 89 59642 11793 56220543
Rheumatoid arthritis 91.11 10.03 167 59564 382437 55849899
Renal impairment 87.03 10.03 234 59497 80479 56151857
Systemic lupus erythematosus 85.64 10.03 42 59689 180036 56052300
Hypotension 85.39 10.03 505 59226 250003 55982333
Maternal exposure during pregnancy 83.50 10.03 410 59321 189143 56043193
Blood pressure increased 82.72 10.03 339 59392 144837 56087499
Arthropathy 82.03 10.03 56 59675 200219 56032117
Caesarean section 80.07 10.03 92 59639 15999 56216337
Neovascularisation 79.97 10.03 33 59698 1016 56231320
Pericarditis 78.80 10.03 11 59720 108912 56123424
Oedema peripheral 76.54 10.03 372 59359 170882 56061454
Contraindicated product administered 76.41 10.03 52 59679 186234 56046102
Therapeutic product effect decreased 75.44 10.03 43 59688 169409 56062927
Wound 74.60 10.03 27 59704 138777 56093559
Discomfort 70.58 10.03 31 59700 141730 56090606
Infusion related reaction 66.68 10.03 74 59657 208857 56023479
Foetal growth restriction 63.89 10.03 56 59675 7043 56225293
Rheumatoid factor positive 60.73 10.03 3 59728 69057 56163279
Proteinuria 58.14 10.03 82 59649 17488 56214848
Helicobacter infection 56.42 10.03 6 59725 73262 56159074
Joint swelling 56.02 10.03 142 59589 289658 55942678
Cardiac failure congestive 54.06 10.03 210 59521 87510 56144826
Drug ineffective 52.97 10.03 674 59057 918315 55314021
Hypersensitivity 52.41 10.03 122 59609 256286 55976050
Synovitis 51.60 10.03 57 59674 161248 56071088
Scleroderma 50.21 10.03 42 59689 4959 56227377
Pulmonary oedema 49.89 10.03 143 59588 51000 56181336
Blood pressure diastolic abnormal 48.97 10.03 61 59670 11537 56220799
Cerebral infarction 48.11 10.03 86 59645 22419 56209917
Dyspnoea exertional 47.73 10.03 147 59584 54542 56177794
Anuria 46.72 10.03 60 59671 11700 56220636
Primary hyperaldosteronism 46.11 10.03 11 59720 47 56232289
Rash 45.72 10.03 321 59410 492726 55739610
Blood pressure systolic abnormal 45.47 10.03 54 59677 9723 56222613
Heart rate decreased 45.36 10.03 119 59612 40308 56192028
Acute pulmonary oedema 43.94 10.03 47 59684 7550 56224786
Abdominal discomfort 43.34 10.03 150 59581 277124 55955212
Paradoxical drug reaction 42.37 10.03 34 59697 3786 56228550
Hepatic enzyme increased 42.32 10.03 73 59658 171311 56061025
Oligohydramnios 41.77 10.03 41 59690 5953 56226383
Intestinal angioedema 41.70 10.03 18 59713 621 56231715
Treatment failure 41.69 10.03 73 59658 170319 56062017
Pain 41.27 10.03 478 59253 662706 55569630
Drug intolerance 40.22 10.03 145 59586 264673 55967663
Drug dispensed to wrong patient 39.97 10.03 13 59718 199 56232137
Aplastic anaemia 39.38 10.03 48 59683 8880 56223456
Transfusion 38.79 10.03 59 59672 13461 56218875
Sinusitis 38.77 10.03 96 59635 197485 56034851
Blood aldosterone increased 38.55 10.03 12 59719 158 56232178
Lower respiratory tract infection 38.45 10.03 39 59692 114755 56117581
Rectal prolapse 37.77 10.03 24 59707 1850 56230486
Eclampsia 37.38 10.03 14 59717 331 56232005
Uraemic encephalopathy 37.31 10.03 13 59718 248 56232088
Drug abuse 36.56 10.03 13 59718 67597 56164739
Hypergammaglobulinaemia 36.43 10.03 15 59716 459 56231877
Bradycardia 36.34 10.03 155 59576 67349 56164987
Dyspnoea 35.74 10.03 851 58880 591726 55640610
Blood creatinine increased 35.63 10.03 174 59557 80017 56152319
Polyhydramnios 35.12 10.03 24 59707 2091 56230245
Bladder prolapse 34.46 10.03 23 59708 1928 56230408
Swelling 33.36 10.03 136 59595 239635 55992701
Impaired healing 33.29 10.03 26 59705 86815 56145521
Dialysis 33.17 10.03 46 59685 9656 56222680
Hypertensive crisis 33.08 10.03 56 59675 13980 56218356
Foetal death 32.84 10.03 43 59688 8544 56223792
Phaeochromocytoma 32.38 10.03 14 59717 485 56231851
Blood pressure systolic increased 32.19 10.03 106 59625 40730 56191606
Cardiac failure 32.19 10.03 172 59559 81921 56150415
Premature separation of placenta 31.69 10.03 21 59710 1739 56230597
Renal artery stenosis 31.02 10.03 21 59710 1802 56230534
Neutropenia 30.91 10.03 77 59654 158090 56074246
Knee arthroplasty 30.78 10.03 5 59726 44254 56188082
Product complaint 30.51 10.03 49 59682 11711 56220625
Psoriasis 30.46 10.03 32 59699 92660 56139676
Respiratory tract inflammation 30.34 10.03 14 59717 567 56231769
Drug ineffective for unapproved indication 30.23 10.03 77 59654 25616 56206720
Product use issue 30.16 10.03 99 59632 185942 56046394
Nodular regenerative hyperplasia 30.10 10.03 13 59718 449 56231887
Injection site erythema 29.92 10.03 23 59708 77425 56154911
Neonatal respiratory distress syndrome 29.46 10.03 24 59707 2730 56229606
Superimposed pre-eclampsia 29.25 10.03 5 59726 0 56232336
CD30 expression 29.14 10.03 7 59724 31 56232305
Angina unstable 29.00 10.03 36 59695 6785 56225551
Infection 28.83 10.03 112 59619 200094 56032242
Hypervolaemia 28.78 10.03 77 59654 26381 56205955
Wrist deformity 28.20 10.03 20 59711 1850 56230486
Fatigue 27.74 10.03 632 59099 787920 55444416
Peripartum cardiomyopathy 27.30 10.03 9 59722 144 56232192
Hyperkalaemia 26.76 10.03 116 59615 50749 56181587
Product residue present 26.52 10.03 26 59705 3769 56228567
Cerebrovascular accident 26.30 10.03 188 59543 99082 56133254
Tubulointerstitial nephritis 26.25 10.03 56 59675 16609 56215727
Blood pressure decreased 26.13 10.03 128 59603 58922 56173414
Renin decreased 26.08 10.03 8 59723 100 56232236
Patent ductus arteriosus 25.64 10.03 26 59705 3925 56228411
Irritable bowel syndrome 25.60 10.03 21 59710 68437 56163899
Pulmonary hypertension 25.43 10.03 90 59641 35854 56196482
Electrocardiogram PR prolongation 25.08 10.03 13 59718 680 56231656
Thermal burn 25.02 10.03 30 59701 5455 56226881
Blood pressure diastolic decreased 24.94 10.03 60 59671 19263 56213073
Psoriatic arthropathy 24.94 10.03 25 59706 73983 56158353
Foetal distress syndrome 24.71 10.03 16 59715 1274 56231062
Foetal exposure timing unspecified 24.51 10.03 9 59722 201 56232135
Blood urea increased 24.41 10.03 69 59662 24404 56207932
Blood pressure fluctuation 24.34 10.03 96 59635 40264 56192072
Renal failure 24.11 10.03 200 59531 110300 56122036
Cognitive disorder 24.03 10.03 11 59720 49122 56183214
Peripheral vascular disorder 23.99 10.03 30 59701 5695 56226641
Pain in jaw 23.96 10.03 95 59636 39941 56192395
Aortic dissection 23.77 10.03 18 59713 1841 56230495
Blister 23.70 10.03 50 59681 108837 56123499
Infrequent bowel movements 23.40 10.03 15 59716 1174 56231162
Oedema 23.38 10.03 158 59573 81762 56150574
Injection site reaction 22.98 10.03 14 59717 53233 56179103
Finger amputation 22.29 10.03 11 59720 518 56231818
Preterm premature rupture of membranes 22.05 10.03 15 59716 1297 56231039
Adverse drug reaction 21.95 10.03 22 59709 65110 56167226
Maternal condition affecting foetus 21.94 10.03 8 59723 175 56232161
Palpitations 21.53 10.03 180 59551 99492 56132844
Diabetic nephropathy 21.52 10.03 15 59716 1349 56230987
HELLP syndrome 21.43 10.03 13 59718 923 56231413
Fibromyalgia 21.41 10.03 19 59712 59584 56172752
Injection site inflammation 21.30 10.03 22 59709 3394 56228942
Stomatitis 21.19 10.03 62 59669 120748 56111588
Endometritis 20.72 10.03 13 59718 980 56231356
Left ventricular hypertrophy 20.70 10.03 26 59705 4958 56227378
Stillbirth 20.55 10.03 29 59702 6185 56226151
Respiratory distress 20.47 10.03 77 59654 31590 56200746
Shock 20.45 10.03 60 59671 21668 56210668
Fluid retention 20.31 10.03 112 59619 53966 56178370
Hip arthroplasty 19.92 10.03 8 59723 38615 56193721
Renal hypoplasia 19.84 10.03 5 59726 28 56232308
Hepatic rupture 19.69 10.03 5 59726 29 56232307
Nephrogenic systemic fibrosis 19.68 10.03 24 59707 4441 56227895
Drug titration error 19.63 10.03 11 59720 673 56231663
Urticaria 19.52 10.03 83 59648 144593 56087743
Porphyria acute 19.16 10.03 12 59719 902 56231434
Hypovolaemic shock 19.16 10.03 26 59705 5347 56226989
Bradycardia foetal 18.72 10.03 9 59722 400 56231936
Myocardial infarction 18.63 10.03 165 59566 92705 56139631
Hepatic function abnormal 18.32 10.03 79 59652 34479 56197857
BRASH syndrome 18.19 10.03 8 59723 289 56232047
Barotrauma 18.14 10.03 7 59724 180 56232156
Drug interaction 18.11 10.03 318 59413 209437 56022899
Atrial septal defect 18.11 10.03 28 59703 6478 56225858
Frostbite 18.09 10.03 6 59725 98 56232238
Urine output decreased 17.89 10.03 37 59694 10740 56221596
Haemoglobin decreased 17.75 10.03 219 59512 133918 56098418
Foetal exposure during delivery 17.69 10.03 5 59726 46 56232290
Vascular resistance systemic increased 17.55 10.03 3 59728 0 56232336
Tocolysis 17.55 10.03 3 59728 0 56232336
Therapeutic product effect incomplete 17.47 10.03 56 59675 105975 56126361
Vitamin D decreased 17.26 10.03 33 59698 9050 56223286
Hypertensive emergency 17.14 10.03 14 59717 1599 56230737
Oral herpes 16.78 10.03 58 59673 22832 56209504
Acute myocardial infarction 16.51 10.03 70 59661 30323 56202013
Multiple sclerosis relapse 16.51 10.03 14 59717 44889 56187447
Chronic kidney disease 16.40 10.03 88 59643 41968 56190368
Intentional product use issue 16.20 10.03 53 59678 99680 56132656
Product substitution error 16.09 10.03 4 59727 21 56232315
Atrioventricular block first degree 15.95 10.03 27 59704 6738 56225598
Febrile neutropenia 15.85 10.03 58 59673 105487 56126849
Laboratory test interference 15.85 10.03 9 59722 565 56231771
Hyperuricaemia 15.79 10.03 23 59708 5050 56227286
Therapy partial responder 15.68 10.03 29 59702 7756 56224580
Angina pectoris 15.64 10.03 65 59666 27911 56204425
Pseudolymphoma 15.59 10.03 9 59722 583 56231753
Extrapyramidal disorder 15.55 10.03 38 59693 12318 56220018
Injection site pruritus 15.51 10.03 13 59718 41918 56190418
Coronary artery disease 15.26 10.03 69 59662 30727 56201609
Cardiomegaly 15.05 10.03 45 59686 16422 56215914
Scleroderma renal crisis 15.02 10.03 7 59724 290 56232046
Ileal ulcer 15.01 10.03 8 59723 443 56231893
Gestational hypertension 14.69 10.03 15 59716 2284 56230052
Metabolic acidosis 14.67 10.03 83 59648 40371 56191965
Renal atrophy 14.61 10.03 12 59719 1381 56230955
Foetal heart rate deceleration abnormality 14.59 10.03 8 59723 469 56231867
Skin induration 14.58 10.03 17 59714 3001 56229335
Foetal hypokinesia 14.45 10.03 8 59723 478 56231858
Malignant hypertension 14.43 10.03 11 59720 1137 56231199
Myocardial depression 14.40 10.03 8 59723 481 56231855
Pulmonary arterial hypertension 14.37 10.03 61 59670 26442 56205894
Respiratory failure 14.26 10.03 159 59572 94903 56137433
Umbilical cord vascular disorder 14.18 10.03 5 59726 99 56232237
Wrong technique in product usage process 14.14 10.03 25 59706 58143 56174193
Altered state of consciousness 14.08 10.03 55 59676 22966 56209370
Aortic valve incompetence 14.04 10.03 23 59708 5589 56226747
Transferrin decreased 14.04 10.03 6 59725 202 56232134
Skin hypertrophy 13.74 10.03 17 59714 3193 56229143
Ventricular hypertrophy 13.62 10.03 17 59714 3221 56229115
Oxygen saturation decreased 13.62 10.03 136 59595 78931 56153405
Hypoaesthesia teeth 13.51 10.03 4 59727 44 56232292
Human chorionic gonadotropin positive 13.51 10.03 4 59727 44 56232292
Type 2 diabetes mellitus 13.44 10.03 18 59713 46844 56185492
Dermatophytosis of nail 13.27 10.03 4 59727 47 56232289
Gastrointestinal disorder 13.22 10.03 68 59663 112634 56119702
Contusion 13.16 10.03 81 59650 128349 56103987
Cortisol increased 13.15 10.03 7 59724 387 56231949
Blood lactate dehydrogenase increased 13.14 10.03 50 59681 20625 56211711
Liver injury 13.13 10.03 15 59716 41833 56190503
Hypoproteinaemia 13.09 10.03 13 59718 1915 56230421
Haemoperitoneum 13.02 10.03 15 59716 2615 56229721
Microvillous inclusion disease 12.94 10.03 3 59728 11 56232325
Platelet count decreased 12.93 10.03 171 59560 106212 56126124
Transient ischaemic attack 12.91 10.03 70 59661 33507 56198829
Spinal cord infarction 12.89 10.03 6 59725 248 56232088
Accidental exposure to product 12.88 10.03 5 59726 24642 56207694
Cervical incompetence 12.84 10.03 8 59723 596 56231740
Neonatal hyponatraemia 12.76 10.03 4 59727 54 56232282
Premature rupture of membranes 12.56 10.03 20 59711 4745 56227591
Joint contracture 12.53 10.03 12 59719 1690 56230646
Hypoxia 12.53 10.03 99 59632 53798 56178538
Jaundice neonatal 12.48 10.03 9 59722 854 56231482
Small for dates baby 12.46 10.03 17 59714 3513 56228823
Feeling cold 12.46 10.03 50 59681 21137 56211199
Blood corticotrophin decreased 12.45 10.03 6 59725 268 56232068
Skin tightness 12.41 10.03 18 59713 3937 56228399
Cardiac arrest 12.32 10.03 143 59588 86171 56146165
Muscle spasticity 12.32 10.03 3 59728 19957 56212379
Antibody test positive 12.26 10.03 14 59717 2417 56229919
Pancreatitis haemorrhagic 12.23 10.03 7 59724 446 56231890
Ill-defined disorder 12.14 10.03 35 59696 68508 56163828
Heliotrope rash 12.05 10.03 5 59726 156 56232180
Hypoglycaemia neonatal 11.96 10.03 9 59722 912 56231424
Neuromuscular blockade 11.92 10.03 6 59725 295 56232041
Systemic scleroderma 11.76 10.03 9 59722 935 56231401
Amniotic cavity infection 11.75 10.03 10 59721 1208 56231128
Hospitalisation 11.50 10.03 126 59605 74874 56157462
Arrhythmia 11.44 10.03 70 59661 35013 56197323
Haemodialysis 11.44 10.03 27 59704 8564 56223772
Injection site pain 11.42 10.03 75 59656 117043 56115293
Wheezing 11.42 10.03 41 59690 74985 56157351
Ductus arteriosus premature closure 11.40 10.03 6 59725 324 56232012
Stevens-Johnson syndrome 11.40 10.03 51 59680 22612 56209724
Carotid artery disease 11.38 10.03 11 59720 1567 56230769
Sinus bradycardia 11.37 10.03 36 59695 13550 56218786
Macular degeneration 11.37 10.03 3 59728 18905 56213431
Suicidal ideation 11.35 10.03 28 59703 57714 56174622
Brain natriuretic peptide increased 11.33 10.03 19 59712 4707 56227629
Joint range of motion decreased 11.23 10.03 55 59676 25310 56207026
Glomerulonephritis membranoproliferative 11.21 10.03 5 59726 187 56232149
Weight increased 11.13 10.03 174 59557 229529 56002807
Nephrotic syndrome 11 10.03 20 59711 5280 56227056
Platelet transfusion 10.94 10.03 8 59723 776 56231560
Haemodialysis complication 10.94 10.03 5 59726 198 56232138
Poikiloderma 10.94 10.03 5 59726 198 56232138
Lacunar infarction 10.88 10.03 15 59716 3130 56229206
Arthralgia 10.84 10.03 429 59302 501240 55731096
Intestinal pseudo-obstruction 10.82 10.03 8 59723 789 56231547
Peripheral ischaemia 10.77 10.03 18 59713 4445 56227891
Foot deformity 10.65 10.03 6 59725 23819 56208517
Mallory-Weiss syndrome 10.63 10.03 10 59721 1377 56230959
Hypoperfusion 10.62 10.03 10 59721 1380 56230956
Device expulsion 10.59 10.03 10 59721 30439 56201897
Hypertensive encephalopathy 10.52 10.03 7 59724 584 56231752
Nasopharyngitis 10.50 10.03 168 59563 220791 56011545
Mental status changes 10.50 10.03 72 59659 37429 56194907
Hyperplasia adrenal 10.48 10.03 3 59728 29 56232307
Temperature intolerance 10.41 10.03 25 59706 8015 56224321
Arteriovenous fistula operation 10.36 10.03 5 59726 224 56232112
Pyuria 10.34 10.03 11 59720 1756 56230580
Congenital hypothyroidism 10.32 10.03 5 59726 226 56232110
Large intestine benign neoplasm 10.25 10.03 4 59727 106 56232230
Right atrial enlargement 10.25 10.03 4 59727 106 56232230
Pulmonary embolism 10.24 10.03 69 59662 107055 56125281
End stage renal disease 10.16 10.03 21 59710 6090 56226246
Exposure via breast milk 10.11 10.03 11 59720 1801 56230535

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 168.50 10.52 158 40558 17908 31638720
Foetal exposure during pregnancy 135.30 10.52 211 40505 40665 31615963
Low birth weight baby 104.22 10.52 80 40636 6890 31649738
Photodermatosis 100.88 10.52 34 40682 477 31656151
Solar lentigo 94.17 10.52 32 40684 461 31656167
Dysplastic naevus 90.88 10.52 31 40685 452 31656176
Off label use 73.36 10.52 217 40499 347057 31309571
Polydactyly 69.82 10.52 33 40683 1161 31655467
Hypertension 68.07 10.52 335 40381 127765 31528863
Gingival hypertrophy 65.73 10.52 36 40680 1734 31654894
Bradycardia 63.75 10.52 215 40501 69112 31587516
Foetal growth restriction 61.93 10.52 46 40670 3769 31652859
Drug abuse 61.82 10.52 18 40698 87740 31568888
Cerebral infarction 57.07 10.52 112 40604 25865 31630763
Renal impairment 54.06 10.52 237 40479 86112 31570516
Drug ineffective 50.05 10.52 301 40415 395272 31261356
Completed suicide 48.32 10.52 239 40477 91275 31565353
Hyperkalaemia 47.64 10.52 186 40530 64165 31592463
Blood creatinine increased 45.87 10.52 231 40485 88847 31567781
Kidney transplant rejection 44.87 10.52 51 40665 7231 31649397
Atrioventricular septal defect 44.47 10.52 15 40701 211 31656417
Blood urea increased 44.24 10.52 108 40608 28904 31627724
Bezoar 43.79 10.52 22 40694 886 31655742
Dandy-Walker syndrome 41.50 10.52 14 40702 197 31656431
Trisomy 21 37.20 10.52 17 40699 553 31656075
Pulmonary hypertension 36.49 10.52 80 40636 19961 31636667
Cardiac failure congestive 36.14 10.52 199 40517 79188 31577440
Protein urine present 34.72 10.52 37 40679 4883 31651745
Shock 34.21 10.52 84 40632 22561 31634067
Actinic keratosis 34.14 10.52 34 40682 4145 31652483
Neutropenia 33.81 10.52 82 40634 140282 31516346
Oesophageal obstruction 33.29 10.52 15 40701 472 31656156
Neurodevelopmental disorder 32.10 10.52 14 40702 407 31656221
Macrocephaly 30.34 10.52 14 40702 466 31656162
Phospholipidosis 29.76 10.52 8 40708 48 31656580
Aplastic anaemia 29.71 10.52 47 40669 9156 31647472
Congenital central nervous system anomaly 28.94 10.52 14 40702 519 31656109
Proteinuria 28.37 10.52 65 40651 16698 31639930
Speech disorder developmental 26.96 10.52 22 40694 2069 31654559
Hepatic function abnormal 26.42 10.52 114 40602 41108 31615520
Chronic kidney disease 25.87 10.52 107 40609 37868 31618760
Gene mutation 25.64 10.52 17 40699 1161 31655467
Aplasia pure red cell 25.37 10.52 34 40682 5703 31650925
Foetal exposure timing unspecified 25.27 10.52 10 40706 226 31656402
Hypotonic-hyporesponsive episode 25.18 10.52 6 40710 20 31656608
Incision site pain 25.14 10.52 20 40696 1814 31654814
Malignant hypertension 23.70 10.52 13 40703 628 31656000
Blood pressure increased 23.53 10.52 179 40537 79454 31577174
Death 23.27 10.52 325 40391 360244 31296384
Cardiac arrest 22.94 10.52 194 40522 88868 31567760
Haemodilution 22.05 10.52 6 40710 38 31656590
Pyelocaliectasis 21.72 10.52 15 40701 1096 31655532
Thrombotic cerebral infarction 21.64 10.52 10 40706 334 31656294
Pre-eclampsia 21.41 10.52 6 40710 43 31656585
Oedema 20.92 10.52 109 40607 42452 31614176
Myocardial infarction 20.31 10.52 229 40487 113225 31543403
Blood pressure decreased 20.18 10.52 118 40598 47973 31608655
Anti-erythropoietin antibody positive 20.10 10.52 13 40703 851 31655777
Lymphocyte count decreased 19.80 10.52 65 40651 20584 31636044
Procedural hypertension 19.64 10.52 6 40710 60 31656568
Renal failure 19.47 10.52 243 40473 123087 31533541
Drug dependence 19.21 10.52 3 40713 22576 31634052
Cutaneous lupus erythematosus 19.17 10.52 12 40704 742 31655886
Hypotension 19.16 10.52 369 40347 204249 31452379
HIV associated nephropathy 19.06 10.52 9 40707 316 31656312
Intestinal pseudo-obstruction 19.04 10.52 16 40700 1567 31655061
Atrioventricular block complete 18.89 10.52 37 40679 8528 31648100
Congenital cystic lung 18.69 10.52 8 40708 222 31656406
Treatment failure 18.65 10.52 15 40701 40777 31615851
Attention deficit hyperactivity disorder 18.65 10.52 19 40697 2379 31654249
Photosensitivity reaction 18.55 10.52 40 40676 9864 31646764
Apnoeic attack 18.37 10.52 9 40707 343 31656285
Blood pressure inadequately controlled 18.19 10.52 19 40697 2450 31654178
Supernumerary nipple 17.58 10.52 5 40711 38 31656590
Mixed connective tissue disease 17.58 10.52 5 40711 38 31656590
Hypertensive crisis 17.43 10.52 35 40681 8212 31648416
Patent ductus arteriosus 17.40 10.52 21 40695 3172 31653456
Renal ischaemia 17.36 10.52 10 40706 531 31656097
Blindness 17.32 10.52 45 40671 12506 31644122
Renal disorder 17.20 10.52 68 40648 23577 31633051
Lacunar infarction 17.12 10.52 20 40696 2920 31653708
Rickets 16.74 10.52 5 40711 46 31656582
Squamous cell carcinoma of skin 16.72 10.52 39 40677 10135 31646493
Cell marker increased 16.63 10.52 9 40707 423 31656205
Metabolic acidosis 16.53 10.52 97 40619 39480 31617148
Myocardial ischaemia 16.46 10.52 53 40663 16614 31640014
Eating disorder symptom 16.42 10.52 4 40712 15 31656613
Caesarean section 16.27 10.52 16 40700 1920 31654708
Hydrops foetalis 16.07 10.52 9 40707 453 31656175
Acute kidney injury 15.96 10.52 471 40245 279243 31377385
Congenital pulmonary valve atresia 15.94 10.52 5 40711 55 31656573
Rheumatoid arthritis 15.84 10.52 23 40693 47786 31608842
Systemic scleroderma 15.84 10.52 8 40708 326 31656302
Pulmonary eosinophilia 15.72 10.52 7 40709 214 31656414
Febrile neutropenia 15.68 10.52 92 40624 121757 31534871
Wrong technique in product usage process 15.57 10.52 12 40704 33331 31623297
Neonatal respiratory failure 15.35 10.52 8 40708 348 31656280
Pituitary tumour recurrent 15.32 10.52 5 40711 63 31656565
Abdominal symptom 15.29 10.52 9 40707 498 31656130
Azotaemia 15.19 10.52 24 40692 4668 31651960
Polyhydramnios 15.06 10.52 7 40709 237 31656391
Cerebrovascular accident 14.93 10.52 162 40554 79322 31577306
Sclerodactylia 14.88 10.52 4 40712 24 31656604
Prinzmetal angina 14.86 10.52 11 40705 896 31655732
Neonatal respiratory distress 14.78 10.52 9 40707 530 31656098
Hyphaema 14.76 10.52 9 40707 531 31656097
Post procedural urine leak 14.71 10.52 6 40710 147 31656481
Drug interaction 14.69 10.52 361 40355 208182 31448446
Brain stem infarction 14.56 10.52 12 40704 1144 31655484
Meningitis staphylococcal 14.53 10.52 5 40711 75 31656553
Naevus flammeus 14.49 10.52 6 40710 153 31656475
Aortic dissection 14.42 10.52 17 40699 2505 31654123
Interstitial lung disease 14.37 10.52 131 40585 61272 31595356
Fatigue 14.29 10.52 325 40391 334881 31321747
Bronchopulmonary dysplasia 14.23 10.52 9 40707 567 31656061
Chorioretinopathy 14.21 10.52 13 40703 1426 31655202
Nausea 14.16 10.52 295 40421 307652 31348976
Cerebral hyperperfusion syndrome 14.12 10.52 5 40711 82 31656546
Red blood cells urine positive 14.05 10.52 14 40702 1708 31654920
Oesophageal haemorrhage 13.97 10.52 12 40704 1211 31655417
Crepitations 13.95 10.52 18 40698 2910 31653718
Nephrogenic systemic fibrosis 13.89 10.52 21 40695 3934 31652694
Thrombocytopenia 13.85 10.52 117 40599 142630 31513998
Palatal swelling 13.67 10.52 4 40712 34 31656594
Agitation 13.54 10.52 31 40685 54138 31602490
Oedema peripheral 13.49 10.52 207 40509 109632 31546996
Ventricular extrasystoles 13.43 10.52 38 40678 11104 31645524
Congenital hearing disorder 13.34 10.52 5 40711 97 31656531
Tubulointerstitial nephritis 13.29 10.52 53 40663 18443 31638185
BRASH syndrome 13.22 10.52 7 40709 315 31656313
Hydrocele male infected 13.10 10.52 4 40712 40 31656588
Exposure during pregnancy 13.09 10.52 32 40684 8566 31648062
Acute lung injury 12.97 10.52 12 40704 1335 31655293
Vomiting 12.97 10.52 206 40510 223767 31432861
Neonatal respiratory distress syndrome 12.76 10.52 20 40696 3865 31652763
Product use in unapproved indication 12.69 10.52 75 40641 99096 31557532
Neonatal cholestasis 12.67 10.52 4 40712 45 31656583
Maternal exposure during pregnancy 12.64 10.52 22 40694 4634 31651994
Renal failure neonatal 12.63 10.52 5 40711 113 31656515
Transplant rejection 12.58 10.52 34 40682 9674 31646954
Bradycardia foetal 12.50 10.52 7 40709 352 31656276
Chronic allograft nephropathy 12.47 10.52 11 40705 1151 31655477
Infantile apnoea 12.41 10.52 10 40706 924 31655704
Product residue present 12.26 10.52 16 40700 2614 31654014
Diabetes mellitus 12.19 10.52 95 40621 42461 31614167
Neuropathy peripheral 12.07 10.52 53 40663 75596 31581032
Neutrophil count increased 12.06 10.52 46 40670 15685 31640943
Pulmonary oedema 12.01 10.52 98 40618 44404 31612224
Hypocalcaemia 12.00 10.52 58 40658 21920 31634708
Kidney infection 11.99 10.52 22 40694 4828 31651800
Blood pressure systolic 11.97 10.52 3 40713 13 31656615
Cardiac cirrhosis 11.88 10.52 4 40712 56 31656572
Putamen haemorrhage 11.78 10.52 6 40710 249 31656379
Therapeutic product effect incomplete 11.75 10.52 24 40692 43672 31612956
Peripheral arterial occlusive disease 11.71 10.52 23 40693 5310 31651318
White blood cell count increased 11.69 10.52 88 40628 38912 31617716
Hyperuricaemia 11.66 10.52 28 40688 7410 31649218
Vertebral artery stenosis 11.54 10.52 5 40711 143 31656485
Skin hypertrophy 11.50 10.52 15 40701 2450 31654178
Haemoglobin decreased 11.49 10.52 206 40510 112469 31544159
Psoriasis 11.46 10.52 27 40689 46692 31609936
Joint range of motion decreased 11.46 10.52 26 40690 6635 31649993
Angina unstable 11.42 10.52 36 40680 11159 31645469
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.35 10.52 9 40707 812 31655816
Maternal drugs affecting foetus 11.33 10.52 19 40697 3884 31652744
Retinopathy of prematurity 11.29 10.52 5 40711 151 31656477
Serotonin syndrome 11.25 10.52 5 40711 18768 31637860
Cardiac murmur 11.20 10.52 26 40690 6736 31649892
Postrenal failure 11.11 10.52 7 40709 438 31656190
Clonic convulsion 11.07 10.52 8 40708 628 31656000
Hepatocellular injury 11.06 10.52 7 40709 21537 31635091
Intentional product use issue 10.96 10.52 30 40686 49317 31607311
Anaemia neonatal 10.93 10.52 6 40710 290 31656338
Atrioventricular block 10.90 10.52 27 40689 7288 31649340
Drug level increased 10.83 10.52 53 40663 20133 31636495
Ventricular septal defect 10.81 10.52 18 40698 3659 31652969
Cerebrovascular insufficiency 10.77 10.52 3 40713 21 31656607
Pemphigoid 10.75 10.52 29 40687 8242 31648386
Angina pectoris 10.71 10.52 70 40646 29571 31627057
Suspected suicide 10.62 10.52 19 40697 4088 31652540

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 373.57 9.70 263 85703 21041 70821437
Exposure during pregnancy 255.69 9.70 414 85552 87303 70755175
Hypertension 157.52 9.70 743 85223 295290 70547188
Pre-eclampsia 149.65 9.70 95 85871 6390 70836088
Renal impairment 130.05 9.70 427 85539 143510 70698968
Cerebral infarction 100.30 9.70 184 85782 42825 70799653
Drug abuse 96.91 9.70 29 85937 147227 70695251
Bradycardia 92.07 9.70 346 85620 124269 70718209
Dysplastic naevus 88.04 9.70 31 85935 531 70841947
Cardiac failure congestive 86.27 9.70 359 85607 135098 70707380
Photodermatosis 85.91 9.70 35 85931 908 70841570
Hypotension 83.65 9.70 802 85164 403579 70438899
Alopecia 83.10 9.70 71 85895 198419 70644059
Premature labour 82.08 9.70 72 85894 7928 70834550
Maternal exposure during pregnancy 80.87 9.70 315 85651 115030 70727448
Blood pressure inadequately controlled 75.47 9.70 59 85907 5533 70836945
Blood creatinine increased 75.21 9.70 358 85608 142643 70699835
Neovascularisation 72.97 9.70 33 85933 1112 70841366
Solar lentigo 72.23 9.70 32 85934 1026 70841452
Hyperkalaemia 71.42 9.70 287 85679 106304 70736174
Proteinuria 70.17 9.70 127 85839 29247 70813231
Neutropenia 68.19 9.70 130 85836 257026 70585452
Blood pressure increased 67.47 9.70 425 85541 188092 70654386
Oedema peripheral 67.18 9.70 490 85476 227601 70614877
Pemphigus 65.34 9.70 11 85955 83025 70759453
Therapeutic product effect decreased 65.09 9.70 47 85919 142971 70699507
Blood urea increased 63.65 9.70 159 85807 45750 70796728
Gingival hypertrophy 63.27 9.70 41 85925 2857 70839621
Pericarditis 60.82 9.70 14 85952 84691 70757787
Glossodynia 58.79 9.70 16 85950 86471 70756007
Aplastic anaemia 57.18 9.70 85 85881 16631 70825847
Rheumatoid arthritis 56.44 9.70 174 85792 291631 70550847
Shock 53.94 9.70 138 85828 40287 70802191
Wound 52.52 9.70 27 85939 98705 70743773
Caesarean section 50.10 9.70 66 85900 11541 70830937
Duodenal ulcer perforation 49.89 9.70 3 85963 51109 70791369
Hypersensitivity 49.60 9.70 130 85836 229682 70612796
Pulmonary oedema 49.21 9.70 214 85752 82064 70760414
Drug ineffective 49.15 9.70 823 85143 938929 69903549
Completed suicide 49.10 9.70 455 85511 226680 70615798
Primary hyperaldosteronism 48.25 9.70 14 85952 123 70842355
Joint swelling 47.53 9.70 153 85813 253058 70589420
Discomfort 46.23 9.70 36 85930 105400 70737078
Arthropathy 46.07 9.70 69 85897 149988 70692490
Kidney transplant rejection 45.12 9.70 58 85908 9903 70832575
Infusion related reaction 44.75 9.70 109 85857 197425 70645053
Hepatic function abnormal 44.66 9.70 182 85784 67814 70774664
Contraindicated product administered 44.20 9.70 59 85907 134553 70707925
Off label use 44.12 9.70 635 85331 742425 70100053
Rheumatoid factor positive 43.94 9.70 4 85962 48396 70794082
Blood pressure decreased 43.03 9.70 222 85744 91293 70751185
Foetal growth restriction 41.53 9.70 27 85939 1892 70840586
Angina unstable 40.90 9.70 71 85895 15822 70826656
Myocardial infarction 40.76 9.70 351 85615 171294 70671184
Hypertensive crisis 40.67 9.70 79 85887 19183 70823295
Synovitis 40.08 9.70 59 85907 129169 70713309
Bezoar 39.32 9.70 28 85938 2278 70840200
Cerebrovascular accident 39.25 9.70 303 85663 143167 70699311
Helicobacter infection 38.39 9.70 10 85956 55646 70786832
Bladder prolapse 38.10 9.70 22 85944 1245 70841233
Oedema 37.32 9.70 234 85732 103347 70739131
Pulmonary hypertension 36.67 9.70 132 85834 46404 70796074
Malignant hypertension 36.62 9.70 23 85943 1518 70840960
Treatment failure 36.34 9.70 75 85891 144067 70698411
Wrong technique in product usage process 36.21 9.70 19 85947 68679 70773799
Scleroderma 36 9.70 37 85929 4964 70837514
Drug interaction 35.73 9.70 655 85311 380786 70461692
Psoriasis 35.63 9.70 40 85926 98393 70744085
Renal failure 35.58 9.70 368 85598 188702 70653776
Muscle injury 35.43 9.70 3 85963 38491 70803987
Tubulointerstitial nephritis 35.26 9.70 104 85862 32972 70809506
Chronic kidney disease 35.13 9.70 157 85809 60900 70781578
Renal artery stenosis 34.58 9.70 30 85936 3254 70839224
Intestinal angioedema 34.48 9.70 18 85948 834 70841644
Cardiac arrest 34.42 9.70 320 85646 159514 70682964
Actinic keratosis 34.31 9.70 38 85928 5552 70836926
Blood aldosterone increased 33.84 9.70 12 85954 210 70842268
Phaeochromocytoma 33.56 9.70 16 85950 609 70841869
Rectal prolapse 33.14 9.70 24 85942 2005 70840473
Dialysis 32.71 9.70 68 85898 17334 70825144
Anuria 32.59 9.70 73 85893 19580 70822898
Aortic dissection 32.39 9.70 31 85935 3816 70838662
Blood pressure systolic abnormal 32.35 9.70 57 85909 12852 70829626
Hepatic enzyme increased 32.21 9.70 91 85875 156899 70685579
Blood pressure diastolic abnormal 32.02 9.70 63 85903 15441 70827037
Drug intolerance 31.73 9.70 153 85813 225534 70616944
Eclampsia 31.48 9.70 11 85955 184 70842294
Lower respiratory tract infection 31.03 9.70 55 85911 111858 70730620
Cardiac failure 30.71 9.70 287 85679 143254 70699224
Impaired healing 30.62 9.70 27 85939 74347 70768131
BRASH syndrome 30.28 9.70 15 85951 622 70841856
Febrile neutropenia 30.20 9.70 136 85830 204182 70638296
Intestinal pseudo-obstruction 30.18 9.70 24 85942 2306 70840172
Fatigue 30.18 9.70 765 85201 823554 70018924
Metabolic acidosis 29.99 9.70 173 85793 74173 70768305
Sinusitis 29.84 9.70 105 85861 169090 70673388
Angina pectoris 29.81 9.70 127 85839 48256 70794222
Polyhydramnios 29.71 9.70 20 85946 1486 70840992
Hyperuricaemia 29.55 9.70 50 85916 10916 70831562
Protein urine present 29.45 9.70 46 85920 9394 70833084
Injection site erythema 29.39 9.70 27 85939 72897 70769581
Hypergammaglobulinaemia 29.31 9.70 15 85951 667 70841811
Adverse drug reaction 29.25 9.70 14 85952 53330 70789148
Systemic lupus erythematosus 29.24 9.70 49 85917 101853 70740625
Incision site pain 28.62 9.70 25 85941 2736 70839742
Superimposed pre-eclampsia 28.58 9.70 5 85961 0 70842478
Acute pulmonary oedema 28.30 9.70 55 85911 13357 70829121
Uraemic encephalopathy 28.27 9.70 14 85952 580 70841898
Heart rate decreased 28.15 9.70 149 85817 61866 70780612
Atrioventricular block first degree 27.28 9.70 50 85916 11623 70830855
Oligohydramnios 27.08 9.70 26 85940 3214 70839264
Haemoglobin decreased 27.00 9.70 373 85593 204786 70637692
Systemic scleroderma 26.98 9.70 17 85949 1128 70841350
Product use issue 26.45 9.70 120 85846 179817 70662661
CD30 expression 26.31 9.70 7 85959 43 70842435
Dyspnoea exertional 26.29 9.70 174 85792 78256 70764222
Wrist deformity 25.90 9.70 20 85946 1842 70840636
Drug dispensed to wrong patient 25.67 9.70 13 85953 565 70841913
Rash 25.63 9.70 450 85516 510112 70332366
Lacunar infarction 25.54 9.70 33 85933 5663 70836815
Oesophageal obstruction 25.38 9.70 15 85951 887 70841591
Psoriatic arthropathy 24.91 9.70 25 85941 64746 70777732
Atrioventricular block complete 24.78 9.70 56 85910 15107 70827371
Acute myocardial infarction 24.61 9.70 162 85804 72725 70769753
Renin decreased 24.14 9.70 8 85958 113 70842365
Coronary artery disease 24.02 9.70 144 85822 62592 70779886
Knee arthroplasty 23.97 9.70 6 85960 34295 70808183
Transfusion 23.79 9.70 63 85903 18773 70823705
White blood cell count increased 23.71 9.70 155 85811 69418 70773060
Intentional product use issue 23.65 9.70 71 85895 120071 70722407
Blood pressure systolic increased 23.59 9.70 134 85832 57125 70785353
Phospholipidosis 23.46 9.70 8 85958 124 70842354
Drug dependence 23.38 9.70 8 85958 37313 70805165
Foetal death 23.19 9.70 33 85933 6206 70836272
Intentional self-injury 23.18 9.70 5 85961 31645 70810833
Pain 23.12 9.70 583 85383 628233 70214245
Aplasia pure red cell 23.10 9.70 36 85930 7338 70835140
Renal hypoplasia 22.78 9.70 5 85961 11 70842467
Thrombocytopenia 22.74 9.70 183 85783 238927 70603551
Peripartum cardiomyopathy 22.56 9.70 8 85958 140 70842338
Low birth weight baby 22.50 9.70 12 85954 581 70841897
Peripheral vascular disorder 22.17 9.70 36 85930 7596 70834882
Infection 22.09 9.70 157 85809 210628 70631850
Endometritis 21.94 9.70 13 85953 772 70841706
Azotaemia 21.76 9.70 36 85930 7717 70834761
Paradoxical drug reaction 21.63 9.70 33 85933 6603 70835875
Altered state of consciousness 21.60 9.70 101 85865 39921 70802557
Finger amputation 21.57 9.70 12 85954 632 70841846
Hypervolaemia 21.28 9.70 100 85866 39606 70802872
Dyspnoea 21.21 9.70 1138 84828 768922 70073556
Myocardial ischaemia 21.11 9.70 71 85895 24129 70818349
Umbilical cord vascular disorder 20.98 9.70 5 85961 18 70842460
Diabetic nephropathy 20.84 9.70 21 85945 2752 70839726
Premature baby 20.46 9.70 23 85943 3416 70839062
Sedation 20.42 9.70 16 85950 46715 70795763
Irritable bowel syndrome 20.28 9.70 19 85947 50831 70791647
Fibromyalgia 20.16 9.70 17 85949 47857 70794621
Acute kidney injury 20.03 9.70 733 85233 473891 70368587
Prinzmetal angina 19.60 9.70 16 85950 1596 70840882
HIV associated nephropathy 19.48 9.70 9 85957 319 70842159
Therapeutic product effect incomplete 19.43 9.70 77 85889 119805 70722673
Left ventricular hypertrophy 19.33 9.70 40 85926 10162 70832316
Oesophageal haemorrhage 19.23 9.70 16 85950 1639 70840839
Sclerodactylia 19.11 9.70 7 85959 135 70842343
Electrocardiogram PR prolongation 19.07 9.70 15 85951 1419 70841059
Preterm premature rupture of membranes 19.04 9.70 14 85952 1197 70841281
Injection site pain 18.78 9.70 76 85890 117543 70724935
Injection site inflammation 18.77 9.70 22 85944 3416 70839062
Product complaint 18.70 9.70 44 85922 12187 70830291
Respiratory tract inflammation 18.69 9.70 12 85954 823 70841655
Stillbirth 18.57 9.70 23 85943 3782 70838696
Thrombotic cerebral infarction 18.49 9.70 10 85956 498 70841980
Renal disorder 18.41 9.70 93 85873 37916 70804562
Abdominal discomfort 18.31 9.70 169 85797 214489 70627989
Vascular resistance systemic increased 18.16 9.70 4 85962 9 70842469
Photosensitivity reaction 17.99 9.70 58 85908 19282 70823196
Sleep disorder 17.90 9.70 36 85930 69836 70772642
Weight increased 17.69 9.70 198 85768 242133 70600345
Pain in jaw 17.67 9.70 100 85866 42569 70799909
Atrioventricular block 17.64 9.70 44 85922 12644 70829834
Product residue present 17.47 9.70 21 85945 3349 70839129
Intracardiac mass 17.36 9.70 6 85960 97 70842381
Arthralgia 17.34 9.70 471 85495 502919 70339559
Hypertensive emergency 17.33 9.70 18 85948 2445 70840033
Ventricular extrasystoles 17.27 9.70 55 85911 18171 70824307
Neuropathy peripheral 17.26 9.70 87 85879 126809 70715669
Multiple sclerosis relapse 17.24 9.70 16 85950 43001 70799477
Condition aggravated 17.19 9.70 391 85575 427244 70415234
Tocolysis 17.15 9.70 3 85963 0 70842478
Haemodialysis 17.00 9.70 53 85913 17313 70825165
Barotrauma 16.85 9.70 7 85959 191 70842287
Pemphigoid 16.80 9.70 46 85920 13976 70828502
Small for dates baby 16.80 9.70 9 85957 440 70842038
General physical health deterioration 16.78 9.70 194 85772 235837 70606641
Thermal burn 16.72 9.70 29 85937 6457 70836021
Squamous cell carcinoma of skin 16.55 9.70 43 85923 12669 70829809
Skin hypertrophy 16.40 9.70 24 85942 4628 70837850
Hepatocellular injury 16.38 9.70 19 85947 46072 70796406
Neutrophil count increased 16.24 9.70 70 85896 26725 70815753
Injection site reaction 16.20 9.70 22 85944 49830 70792648
Putamen haemorrhage 16.11 9.70 9 85957 478 70842000
Nodular regenerative hyperplasia 16.07 9.70 13 85953 1280 70841198
Hip arthroplasty 15.93 9.70 7 85959 28033 70814445
Platelet transfusion 15.85 9.70 16 85950 2102 70840376
Product use in unapproved indication 15.75 9.70 168 85798 207310 70635168
Brain stem infarction 15.72 9.70 15 85951 1840 70840638
Palpitations 15.64 9.70 204 85762 110549 70731929
Nephrogenic systemic fibrosis 15.52 9.70 27 85939 6025 70836453
Maternal condition affecting foetus 15.40 9.70 6 85960 138 70842340
Hypertensive encephalopathy 15.38 9.70 11 85955 901 70841577
HELLP syndrome 15.34 9.70 10 85956 704 70841774
Hypocalcaemia 15.32 9.70 100 85866 44759 70797719
Haemodilution 15.20 9.70 6 85960 143 70842335
Aggression 15.13 9.70 22 85944 48424 70794054
Cognitive disorder 15.12 9.70 32 85934 60924 70781554
Diabetes mellitus 15.05 9.70 143 85823 71681 70770797
Premature separation of placenta 15.03 9.70 12 85954 1160 70841318
Blood lactate dehydrogenase increased 14.99 9.70 83 85883 35044 70807434
Wheezing 14.93 9.70 61 85905 94109 70748369
Nephrotic syndrome 14.90 9.70 37 85929 10603 70831875
Gastroenteritis 14.86 9.70 76 85890 31137 70811341
Peritoneal dialysis complication 14.77 9.70 16 85950 2280 70840198
Vitamin D decreased 14.76 9.70 32 85934 8395 70834083
Nephrogenic anaemia 14.74 9.70 20 85946 3598 70838880
Nodal rhythm 14.71 9.70 18 85948 2923 70839555
Urticaria 14.49 9.70 127 85839 162922 70679556
Tricuspid valve incompetence 14.43 9.70 51 85915 17766 70824712
Accidental exposure to product 14.43 9.70 8 85958 28043 70814435
Lymphocyte count decreased 14.23 9.70 96 85870 43443 70799035
Mucosal erosion 14.22 9.70 15 85951 2074 70840404
Gestational hypertension 14.21 9.70 14 85952 1786 70840692
Swelling 14.17 9.70 153 85813 188386 70654092
Amniotic cavity infection 14.16 9.70 10 85956 803 70841675
Porphyria acute 14.11 9.70 12 85954 1267 70841211
Procedural hypertension 14.09 9.70 7 85959 292 70842186
Peritoneal dialysis 14.05 9.70 10 85956 813 70841665
Hyphaema 14.05 9.70 10 85956 813 70841665
Peripheral ischaemia 13.93 9.70 32 85934 8726 70833752
Ventricular hypertrophy 13.89 9.70 27 85939 6557 70835921
Blood pressure diastolic decreased 13.87 9.70 65 85901 25715 70816763
Foot deformity 13.70 9.70 4 85962 20651 70821827
Fluid retention 13.68 9.70 127 85839 63258 70779220
Human chorionic gonadotropin positive 13.60 9.70 4 85962 37 70842441
Blood albumin decreased 13.56 9.70 58 85908 22069 70820409
Renal ischaemia 13.52 9.70 11 85955 1092 70841386
Hyperplasia adrenal 13.41 9.70 4 85962 39 70842439
Diabetic retinopathy 13.33 9.70 17 85949 2880 70839598
Platelet count decreased 13.30 9.70 296 85670 177926 70664552
Cardiac failure acute 13.27 9.70 49 85917 17438 70825040
Hypoaesthesia teeth 13.24 9.70 4 85962 41 70842437
Hot flush 13.18 9.70 25 85941 49559 70792919
Brain natriuretic peptide increased 13.16 9.70 30 85936 8141 70834337
Anti-erythropoietin antibody positive 13.12 9.70 9 85957 690 70841788
Sinus arrhythmia 13.10 9.70 14 85952 1964 70840514
Arteriospasm coronary 13.07 9.70 25 85941 5999 70836479
Injection site pruritus 13.05 9.70 17 85949 39193 70803285
Bradycardia foetal 13.04 9.70 5 85961 110 70842368
Blood glucose increased 13.04 9.70 186 85780 102796 70739682
Myocardial depression 13.02 9.70 8 85958 508 70841970
COVID-19 13 9.70 75 85891 105682 70736796
Haemoperitoneum 12.93 9.70 20 85946 4051 70838427
Peritonitis bacterial 12.93 9.70 32 85934 9152 70833326
Cerebral hyperperfusion syndrome 12.91 9.70 5 85961 113 70842365
Product substitution error 12.90 9.70 4 85962 45 70842433
Renal atrophy 12.90 9.70 13 85953 1704 70840774
Neutropenic sepsis 12.89 9.70 7 85959 24823 70817655
Joint range of motion decreased 12.83 9.70 64 85902 25962 70816516
Nasopharyngitis 12.72 9.70 191 85775 222015 70620463
Muscle spasticity 12.72 9.70 4 85962 19685 70822793
Meningitis staphylococcal 12.67 9.70 5 85961 119 70842359
Paranasal sinus inflammation 12.57 9.70 6 85960 229 70842249
Peripheral arterial occlusive disease 12.57 9.70 28 85938 7481 70834997
Urine output decreased 12.41 9.70 47 85919 16923 70825555
Diverticulum intestinal haemorrhagic 12.39 9.70 18 85948 3449 70839029
Post transplant distal limb syndrome 12.32 9.70 8 85958 559 70841919
Accidental exposure to product by child 12.18 9.70 16 85950 2790 70839688
Red blood cells urine positive 12.07 9.70 21 85945 4688 70837790
Interstitial lung disease 12.05 9.70 186 85780 104499 70737979
Shunt stenosis 11.87 9.70 11 85955 1301 70841177
Cardiomegaly 11.85 9.70 60 85906 24485 70817993
Laboratory test interference 11.84 9.70 10 85956 1046 70841432
Hydronephrosis 11.81 9.70 43 85923 15199 70827279
Ileus paralytic 11.78 9.70 30 85936 8731 70833747
Chorioretinopathy 11.76 9.70 14 85952 2211 70840267
Apnoeic attack 11.74 9.70 8 85958 606 70841872
Hepatic rupture 11.73 9.70 4 85962 62 70842416
Blood pressure fluctuation 11.63 9.70 116 85850 58896 70783582
Post procedural urine leak 11.63 9.70 5 85961 149 70842329
Sinus bradycardia 11.58 9.70 58 85908 23565 70818913
Pituitary tumour recurrent 11.56 9.70 5 85961 151 70842327
Lactic acidosis 11.48 9.70 125 85841 64899 70777579
Renal cyst haemorrhage 11.40 9.70 8 85958 636 70841842
High density lipoprotein decreased 11.39 9.70 19 85947 4100 70838378
Gastric cancer 11.36 9.70 30 85936 8925 70833553
Heliotrope rash 11.30 9.70 5 85961 160 70842318
Arteriosclerosis 11.29 9.70 45 85921 16593 70825885
Fibroadenoma of breast 11.26 9.70 6 85960 290 70842188
Decreased appetite 11.25 9.70 464 85502 304316 70538162
Low density lipoprotein increased 11.24 9.70 28 85938 8037 70834441
Frostbite 11.21 9.70 5 85961 163 70842315
Shunt occlusion 11.16 9.70 11 85955 1404 70841074
Mobility decreased 11.13 9.70 76 85890 102923 70739555
Electrocardiogram QRS complex shortened 11.08 9.70 8 85958 665 70841813
Dermatophytosis of nail 11.04 9.70 5 85961 169 70842309
Ill-defined disorder 11.02 9.70 32 85934 54709 70787769
Blood uric acid increased 10.99 9.70 30 85936 9099 70833379
End stage renal disease 10.92 9.70 34 85932 11099 70831379
Abdominal symptom 10.89 9.70 8 85958 683 70841795
Arrhythmia 10.89 9.70 110 85856 56033 70786445
Lip haemorrhage 10.89 9.70 10 85956 1169 70841309
Clostridium difficile infection 10.82 9.70 19 85947 38797 70803681
Hypermagnesaemia 10.80 9.70 10 85956 1181 70841297
Pulmonary embolism 10.72 9.70 129 85837 155738 70686740
Atrioventricular dissociation 10.72 9.70 6 85960 320 70842158
Chest discomfort 10.72 9.70 211 85755 124170 70718308
Periodontitis 10.70 9.70 19 85947 4309 70838169
Renal-limited thrombotic microangiopathy 10.70 9.70 3 85963 23 70842455
Cardiac failure chronic 10.67 9.70 32 85934 10237 70832241
Bradyarrhythmia 10.62 9.70 18 85948 3935 70838543
Pyuria 10.60 9.70 13 85953 2117 70840361
Immunodeficiency 10.59 9.70 4 85962 17551 70824927
Cervical incompetence 10.56 9.70 7 85959 507 70841971
Vertebral artery stenosis 10.55 9.70 5 85961 188 70842290
Device expulsion 10.53 9.70 7 85959 22239 70820239
Foetal hypokinesia 10.52 9.70 6 85960 332 70842146
Pancreatitis haemorrhagic 10.50 9.70 8 85958 722 70841756
Transferrin decreased 10.50 9.70 6 85960 333 70842145
Peripheral coldness 10.48 9.70 40 85926 14460 70828018
Pulmonary arterial hypertension 10.47 9.70 72 85894 32783 70809695
Cholestasis 10.37 9.70 27 85939 47845 70794633
Peripheral embolism 10.35 9.70 12 85954 1842 70840636
Pleural effusion 10.33 9.70 222 85744 132642 70709836
Carotid artery disease 10.30 9.70 13 85953 2180 70840298
Blood calcium increased 10.28 9.70 29 85937 8964 70833514
Acantholysis 10.28 9.70 3 85963 27 70842451
Gastric ileus 10.28 9.70 3 85963 27 70842451
Restrictive cardiomyopathy 10.27 9.70 9 85957 989 70841489
Cerebral haemorrhage 10.19 9.70 105 85861 53759 70788719
Staphylococcal infection 10.19 9.70 32 85934 53372 70789106
Vomiting 10.14 9.70 602 85364 592509 70249969
Poisoning deliberate 10.11 9.70 4 85962 17056 70825422
Raynaud's phenomenon 10.05 9.70 9 85957 1018 70841460
Lymphopenia 10.03 9.70 11 85955 27348 70815130
Ileal ulcer 10.02 9.70 9 85957 1022 70841456
Mallory-Weiss syndrome 9.98 9.70 14 85952 2597 70839881
Withdrawal hypertension 9.97 9.70 6 85960 367 70842111
Atrioventricular block second degree 9.95 9.70 24 85942 6754 70835724
Live birth 9.95 9.70 38 85928 13741 70828737
Dehydration 9.94 9.70 351 85615 225791 70616687
Urticaria pigmentosa 9.90 9.70 3 85963 31 70842447
Crepitations 9.86 9.70 28 85938 8686 70833792
Pseudolymphoma 9.83 9.70 9 85957 1048 70841430
Colon gangrene 9.82 9.70 3 85963 32 70842446
Vascular resistance systemic decreased 9.82 9.70 5 85961 220 70842258
Complications of transplanted kidney 9.79 9.70 22 85944 5912 70836566
Ear infection 9.73 9.70 12 85954 28324 70814154
Glomerulonephritis membranoproliferative 9.73 9.70 7 85959 579 70841899
Acute myeloid leukaemia 9.71 9.70 14 85952 30926 70811552
Ischaemic skin ulcer 9.70 9.70 4 85962 107 70842371
Gangrene 9.70 9.70 27 85939 8282 70834196

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07FB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C08CA05 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08CA55 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08GA01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
CALCIUM CHANNEL BLOCKERS AND DIURETICS
Calcium channel blockers and diuretics
FDA CS M0006414 Dihydropyridines
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175421 Dihydropyridine Calcium Channel Blocker
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D012102 Reproductive Control Agents
MeSH PA D015149 Tocolytic Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:38215 calcium channel blockers
CHEBI has role CHEBI:66993 tocolytic drugs
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Premature labor off-label use 6383007
Raynaud's phenomenon off-label use 266261006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Stenosis of intestine contraindication 23065003
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Chronic idiopathic constipation contraindication 82934008
Left heart failure contraindication 85232009
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Disease of liver contraindication 235856003 DOID:409
Pyloric obstruction contraindication 244815007
Peripheral edema contraindication 271809000
Continent ileostomy - stoma contraindication 311414006
Non-Q wave myocardial infarction contraindication 314207007
Acute coronary syndrome contraindication 394659003
Porphyria contraindication 418470004
Severe Aortic Valve Stenosis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel GATING INHIBITOR IC50 7.70 IUPHAR CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER Kd 9.40 CHEMBL SCIENTIFIC LITERATURE
Adenosine receptor A2a GPCR Ki 4.65 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.30 WOMBAT-PK
Cytochrome P450 3A4 Enzyme IC50 5.26 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 6.50 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.02 DRUG MATRIX
Adenosine receptor A1 GPCR Ki 5.35 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 5.08 CHEMBL
Glutathione reductase, mitochondrial Enzyme Ki 4.76 CHEMBL
Transthyretin Secreted IC50 5.66 WOMBAT-PK
Glycine receptor subunit alpha-1 Ion channel IC50 5.48 CHEMBL
Bile salt export pump Transporter IC50 4.51 CHEMBL
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 4.67 WOMBAT-PK
Cytochrome P450 1A2 Enzyme IC50 6.52 DRUG MATRIX
Potassium voltage-gated channel subfamily A member 1 Ion channel IC50 4.02 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel INHIBITOR IC50 6.30 IUPHAR
Potassium voltage-gated channel subfamily A member 5 Ion channel IC50 5.21 CHEMBL
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Enzyme IC50 4.36 DRUG MATRIX
Glycine receptor subunit beta Ion channel ANTAGONIST IC50 5.90 IUPHAR
Potassium voltage-gated channel subfamily A member 2 Ion channel Kd 4.70 WOMBAT-PK
Myosin light chain kinase, smooth muscle Kinase IC50 5.69 CHEMBL
Thromboxane-A synthase Enzyme IC50 4.73 DRUG MATRIX
Voltage-dependent L-type calcium channel subunit alpha-1F Ion channel GATING INHIBITOR IC50 6 IUPHAR
Glycine receptor subunit alpha-3 Ion channel ANTAGONIST IC50 4.50 IUPHAR
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.43 CHEMBL
C-C chemokine receptor type 2 GPCR Ki 6.07 DRUG MATRIX
Sodium/nucleoside cotransporter 1 Transporter Ki 5.09 DRUG MATRIX
Arachidonate 15-lipoxygenase Enzyme IC50 4.82 DRUG MATRIX
Adenosine receptor A1 GPCR Ki 5.54 CHEMBL
Acetylcholinesterase Enzyme Ki 5.40 CHEMBL
Adenosine receptor A2a GPCR Ki 4.74 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 9 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 8.46 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel Ki 8.92 CHEMBL
Cholinesterase Enzyme Ki 5.92 CHEMBL
Indoleamine 2,3-dioxygenase 2 Enzyme IC50 5.82 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 8.59 CHEMBL
Voltage-gated L-type calcium channel Ion channel Ki 8.33 CHEMBL
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 4.34 CHEMBL
Potassium voltage-gated channel subfamily A member 7 Ion channel BLOCKER IC50 4.90 IUPHAR
Potassium voltage-gated channel subfamily A member 1 Ion channel BLOCKER IC50 4 IUPHAR
Potassium voltage-gated channel subfamily A member 2 Ion channel BLOCKER Kd 4.70 IUPHAR
Potassium channel subfamily K member 2 Ion channel IC50 5.09 CHEMBL
Bile salt export pump Transporter IC50 4.34 CHEMBL

External reference:

IDSource
4018390 VUID
N0000146717 NUI
D00437 KEGG_DRUG
4018390 VANDF
C0028066 UMLSCUI
CHEBI:7565 CHEBI
C5U PDB_CHEM_ID
CHEMBL193 ChEMBL_ID
DB01115 DRUGBANK_ID
D009543 MESH_DESCRIPTOR_UI
4485 PUBCHEM_CID
2514 IUPHAR_LIGAND_ID
3222 INN_ID
I9ZF7L6G2L UNII
7417 RXNORM
2302 MMSL
5175 MMSL
d00051 MMSL
000710 NDDF
017700 NDDF
387490003 SNOMEDCT_US
85272000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Procardia XL HUMAN PRESCRIPTION DRUG LABEL 1 0069-2650 TABLET, FILM COATED, EXTENDED RELEASE 30 mg ORAL NDA 20 sections
Procardia XL HUMAN PRESCRIPTION DRUG LABEL 1 0069-2660 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL NDA 20 sections
Procardia XL HUMAN PRESCRIPTION DRUG LABEL 1 0069-2670 TABLET, FILM COATED, EXTENDED RELEASE 90 mg ORAL NDA 20 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2497 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0228-2530 CAPSULE, LIQUID FILLED 20 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7080 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7080 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7081 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7081 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7082 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7082 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7208 TABLET, EXTENDED RELEASE 30 mg ORAL ANDA 12 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 0904-7229 CAPSULE 10 mg ORAL ANDA 19 sections
NIFEDIPINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-319 CAPSULE, LIQUID FILLED 10 mg ORAL ANDA 19 sections
NIFEDIPINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-948 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections
nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 21695-807 TABLET, FILM COATED, EXTENDED RELEASE 90 mg ORAL ANDA 20 sections
nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 21695-908 TABLET, FILM COATED, EXTENDED RELEASE 30 mg ORAL ANDA 20 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 21695-909 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 14 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-194 CAPSULE 10 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-194 CAPSULE 10 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-195 CAPSULE 20 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 23155-195 CAPSULE 20 mg ORAL ANDA 19 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-009 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-009 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-009 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-009 TABLET, EXTENDED RELEASE 90 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-010 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-010 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-010 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections
Nifedipine HUMAN PRESCRIPTION DRUG LABEL 1 24979-010 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections