hydrochlorothiazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 1385 58-93-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrochlorothiazide
  • hydrochlorothiazid
  • hydrochlorthiazide
  • hydrochlorzide
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
  • Molecular weight: 297.73
  • Formula: C7H8ClN3O4S2
  • CLOGP: -0.36
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -2.12
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O
25 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.72 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 100 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.18 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.56 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.157 Moderate 0.70
caco2-efflux Caco-2 efflux ratio (BA/AB) 5.333 Moderate 0.70
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.546 10^-6 cm/s Moderate 0.70
dh-clint Dog hepatocyte intrinsic clearance 1.592 uL/min/10^6 cells Moderate 0.70
dppb Dog plasma protein binding (% unbound) 52.300 % Moderate 0.70
fcs-ppb Fetal calf serum protein binding (% unbound) 63.310 % Moderate 0.70
herg hERG pIC50 3.962 pIC50 Moderate 0.70
hh-clint Human hepatocyte intrinsic clearance 1.081 uL/min/10^6 cells Moderate 0.70
hlm-clint Human liver microsomal intrinsic clearance 2.999 uL/min/mg protein Moderate 0.70
hppb Human plasma protein binding (% unbound) 58.050 % Moderate 0.70
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK3,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70 49
kinase-selectivity-class AXL,GRK2,MAP2K6,MAPKAPK3,PDK1,PDK2,PIK3CB,TEK,ZAP70 9
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.811 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.809 Moderate 0.70
mh-clint Mouse hepatocyte intrinsic clearance 2.576 Moderate 0.70
mppb Mouse plasma protein binding (% unbound) 56.470 Moderate 0.70
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.633 Moderate 0.70
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 72.270 % Moderate 0.70
rat-kpuu-brain Rat brain Kpuu 0.008 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.225 uL/min/10^6 cells Moderate 0.70
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.690 % Moderate 0.70
rppb Rat plasma protein binding (% unbound) 52.070 % Moderate 0.70
solubility-dd Solubility at pH 7.4 in DMSO 616.595 uM Moderate 0.70

Approvals:

DateAgencyCompanyOrphan
Feb. 12, 1959 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1674.76 9.47 2031 269300 131507 90225609
Pemphigus 906.85 9.47 14 271317 326850 90030266
Hand deformity 753.65 9.47 31 271300 296331 90060785
Maternal exposure during pregnancy 746.77 9.47 98 271233 359965 89997151
Systemic lupus erythematosus 714.51 9.47 114 271217 361782 89995334
Hypokalaemia 713.01 9.47 1351 269980 129765 90227351
Glossodynia 698.36 9.47 75 271256 321704 90035412
Anti-cyclic citrullinated peptide antibody positive 679.00 9.47 5 271326 236428 90120688
Duodenal ulcer perforation 633.88 9.47 5 271326 221283 90135833
Acute kidney injury 610.16 9.47 2226 269105 318161 90038955
Synovitis 510.69 9.47 175 271156 329577 90027539
Folliculitis 501.18 9.47 27 271304 204326 90152790
Wound 479.28 9.47 155 271176 302825 90054291
Blood pressure increased 476.53 9.47 1485 269846 195732 90161384
Pericarditis 472.33 9.47 114 271217 270037 90087079
Helicobacter infection 464.69 9.47 64 271267 226786 90130330
Muscle injury 443.86 9.47 20 271311 176634 90180482
Lower respiratory tract infection 398.55 9.47 127 271204 250532 90106584
Irritable bowel syndrome 385.97 9.47 76 271255 207372 90149744
Cerebrovascular accident 364.26 9.47 999 270332 122534 90234582
Exposure during pregnancy 361.31 9.47 131 271200 238279 90118837
Contraindicated product administered 356.25 9.47 263 271068 319876 90037240
Myocardial infarction 354.19 9.47 898 270433 105074 90252042
Treatment failure 341.66 9.47 247 271084 303681 90053435
Sleep disorder due to general medical condition, insomnia type 339.04 9.47 10 271321 128684 90228432
Impaired healing 334.58 9.47 141 271190 234058 90123058
Arthropathy 329.89 9.47 366 270965 365876 89991240
Discomfort 318.85 9.47 215 271116 274120 90082996
Rheumatoid factor positive 316.95 9.47 64 271267 171586 90185530
Blister 296.12 9.47 200 271131 254798 90102318
Liver injury 292.14 9.47 75 271256 170492 90186624
Off label use 289.12 9.47 2025 269306 1100227 89256889
Dehydration 288.19 9.47 1250 270081 193197 90163919
Drug intolerance 284.75 9.47 569 270762 447022 89910094
Blood potassium decreased 282.03 9.47 510 270821 47217 90309899
Macular degeneration 281.66 9.47 449 270882 37521 90319595
Facet joint syndrome 257.87 9.47 8 271323 98381 90258735
Fall 256.87 9.47 2382 268949 479428 89877688
Alopecia 254.44 9.47 705 270626 494366 89862750
Joint range of motion decreased 249.52 9.47 51 271280 135592 90221524
Swelling 247.03 9.47 556 270775 418502 89938614
Stomatitis 246.71 9.47 275 271056 274423 90082693
Type 2 diabetes mellitus 246.04 9.47 152 271179 203092 90154024
C-reactive protein abnormal 238.40 9.47 46 271285 127383 90229733
Psoriatic arthropathy 235.78 9.47 202 271129 228133 90128983
Infusion related reaction 234.42 9.47 567 270764 416213 89940903
Ill-defined disorder 234.08 9.47 131 271200 184760 90172356
Fibromyalgia 233.84 9.47 166 271165 206103 90151013
Hepatic enzyme increased 229.82 9.47 458 270873 360278 89996838
Lactic acidosis 228.47 9.47 482 270849 49981 90307135
Breast cancer stage III 228.32 9.47 5 271326 84442 90272674
Palpitations 225.19 9.47 908 270423 135820 90221296
Angioedema 224.28 9.47 557 270774 64319 90292797
Syncope 220.08 9.47 883 270448 131780 90225336
Hypotension 219.45 9.47 1696 269635 323701 90033415
Live birth 216.61 9.47 4 271327 79103 90278013
Mobility decreased 211.22 9.47 264 271067 250470 90106646
Infection 207.22 9.47 488 270843 361606 89995510
Lip dry 203.08 9.47 30 271301 100925 90256191
Joint swelling 199.96 9.47 802 270529 502498 89854618
Abdominal discomfort 198.34 9.47 747 270584 476581 89880535
Blood glucose increased 188.63 9.47 671 270660 94575 90262541
Drug interaction 183.04 9.47 1435 269896 275018 90082098
Transient ischaemic attack 182.37 9.47 401 270930 42775 90314341
Angina pectoris 179.54 9.47 376 270955 38784 90318332
Arterial occlusive disease 178.45 9.47 203 271128 12243 90344873
Wound infection 177.96 9.47 49 271282 106353 90250763
Eosinophilic bronchitis 176.32 9.47 68 271263 575 90356541
Coronary artery disease 175.82 9.47 341 270990 33282 90323834
Peripheral venous disease 175.77 9.47 22 271309 83899 90273217
Grip strength decreased 167.79 9.47 36 271295 92540 90264576
Product use issue 157.53 9.47 486 270845 329433 90027683
Autoimmune disorder 156.23 9.47 22 271309 76722 90280394
Inappropriate antidiuretic hormone secretion 152.05 9.47 236 271095 19269 90337847
Gangrene 150.07 9.47 189 271142 12687 90344429
Prescribed overdose 148.89 9.47 53 271278 97572 90259544
Dizziness 147.39 9.47 2530 268801 586754 89770362
Hypersensitivity 146.41 9.47 782 270549 453895 89903221
Therapeutic product effect decreased 146.34 9.47 390 270941 277181 90079935
Condition aggravated 144.45 9.47 1117 270214 594428 89762688
Cataract 140.26 9.47 505 270826 71587 90285529
Adjustment disorder with depressed mood 137.51 9.47 8 271323 56745 90300371
Cardiac failure congestive 137.40 9.47 623 270708 98071 90259045
Nausea 136.69 9.47 4315 267016 1106001 89251115
Therapy non-responder 134.98 9.47 126 271205 136578 90220538
Neurologic neglect syndrome 134.88 9.47 149 271182 8698 90348418
Bursitis 133.98 9.47 118 271213 131536 90225580
Intentional product use issue 132.39 9.47 282 271049 216610 90140506
Lower limb fracture 131.63 9.47 45 271286 84968 90272148
Carotid artery thrombosis 131.55 9.47 149 271182 8943 90348173
Blepharospasm 130.81 9.47 9 271322 55436 90301680
Blood pressure inadequately controlled 129.67 9.47 124 271207 6100 90351016
Sleep disorder 127.21 9.47 250 271081 197780 90159336
Cardiospasm 126.24 9.47 95 271236 3351 90353765
Atrial tachycardia 126.05 9.47 120 271211 5870 90351246
Palmoplantar keratoderma 124.75 9.47 95 271236 3412 90353704
Renal failure 123.49 9.47 742 270589 130265 90226851
Night sweats 122.12 9.47 123 271208 128643 90228473
Skin haemorrhage 121.90 9.47 225 271106 21155 90335961
Injury 119.27 9.47 258 271073 197091 90160025
Sinus congestion 118.42 9.47 257 271074 27167 90329949
Adjustment disorder 117.93 9.47 145 271186 9497 90347619
Wheezing 117.69 9.47 345 270986 237735 90119381
Blood cholesterol increased 116.77 9.47 283 271048 207729 90149387
Chronic sinusitis 115.53 9.47 234 271097 23568 90333548
Hip arthroplasty 115.14 9.47 42 271289 76166 90280950
Cough 114.86 9.47 1644 269687 367318 89989798
Sprue-like enteropathy 113.57 9.47 56 271275 897 90356219
Onychomadesis 112.94 9.47 6 271325 45992 90311124
Carotid artery occlusion 112.94 9.47 116 271215 6226 90350890
Pruritus genital 112.83 9.47 100 271231 4458 90352658
Pregnancy 112.70 9.47 24 271307 62023 90295093
Blood sodium decreased 111.60 9.47 252 271079 27361 90329755
Asthenia 111.22 9.47 2228 269103 531523 89825593
Epilepsy 107.28 9.47 56 271275 82150 90274966
Sleep terror 106.66 9.47 96 271235 4368 90352748
Hypoglycaemia 105.62 9.47 452 270879 69396 90287720
Pancreatitis acute 104.99 9.47 270 271061 31845 90325271
Skin exfoliation 103.87 9.47 441 270890 67472 90289644
Drug ineffective 103.61 9.47 3259 268072 1381039 88976077
Hemiplegia 103.59 9.47 179 271152 15981 90341135
Atrial fibrillation 103.38 9.47 720 270611 132891 90224225
Motor dysfunction 102.95 9.47 197 271134 19033 90338083
Feeling abnormal 102.38 9.47 853 270478 166382 90190734
Hypercholesterolaemia 101.96 9.47 91 271240 100801 90256315
Personality disorder 101.83 9.47 154 271177 12290 90344826
Coordination abnormal 101.34 9.47 208 271123 21148 90335968
Dysarthria 101.21 9.47 376 270955 54106 90303010
Product use in unapproved indication 98.57 9.47 596 270735 335640 90021476
Tension headache 98.49 9.47 117 271214 7392 90349724
Lung disorder 98.17 9.47 187 271144 149696 90207420
Hypercalcaemia 97.95 9.47 274 271057 33966 90323150
Sensory loss 97.79 9.47 186 271145 17889 90339227
Hypertensive crisis 96.21 9.47 183 271148 17601 90339515
Loss of employment 93.45 9.47 75 271256 2912 90354204
Vaginal flatulence 93.09 9.47 149 271182 12489 90344627
Blood urea increased 92.60 9.47 249 271082 30164 90326952
Hyperkalaemia 91.84 9.47 412 270919 64552 90292564
Facial pain 91.11 9.47 151 271180 13031 90344085
Sciatica 90.37 9.47 102 271229 101280 90255836
Anosmia 87.97 9.47 127 271204 9721 90347395
Obesity 87.83 9.47 112 271219 105395 90251721
Immunisation 87.78 9.47 64 271267 2149 90354967
Blood pressure systolic increased 87.78 9.47 377 270954 57968 90299148
C-reactive protein increased 86.64 9.47 267 271064 181122 90175994
Gait inability 86.39 9.47 194 271137 146262 90210854
Breast cancer stage II 85.55 9.47 5 271326 35329 90321787
Oedema 85.28 9.47 310 271021 199985 90157131
Urticaria 85.15 9.47 567 270764 312167 90044949
Blood pressure diastolic decreased 85.09 9.47 223 271108 26603 90330513
Hypochloraemia 84.52 9.47 67 271264 2555 90354561
Radiculopathy 84.02 9.47 177 271154 18328 90338788
Hemiparesis 82.68 9.47 246 271085 31573 90325543
Musculoskeletal stiffness 82.57 9.47 534 270797 295998 90061118
Polyp 82.48 9.47 108 271223 7536 90349580
Bone erosion 82.19 9.47 28 271303 52993 90304123
Paraesthesia oral 81.55 9.47 244 271087 31415 90325701
Hypovolaemia 81.40 9.47 139 271192 12292 90344824
Proctitis 81.29 9.47 156 271175 15103 90342013
Blood creatinine increased 81.17 9.47 551 270780 100835 90256281
Subarachnoid haemorrhage 81 9.47 171 271160 17733 90339383
Lung diffusion test abnormal 80.85 9.47 32 271299 292 90356824
Eating disorder 80.65 9.47 225 271106 27848 90329268
Abortion spontaneous 79.64 9.47 31 271300 54025 90303091
Sinus disorder 78.11 9.47 254 271077 34193 90322923
Sneezing 77.69 9.47 231 271100 29638 90327478
Liver function test increased 77.14 9.47 84 271247 84771 90272345
Rhabdomyolysis 75.42 9.47 329 271002 50927 90306189
Disorientation 73.39 9.47 294 271037 43820 90313296
Rash 72.08 9.47 1824 269507 794276 89562840
Aphasia 71.76 9.47 286 271045 42526 90314590
Dysphagia 71.55 9.47 578 270753 111700 90245416
Blood lactic acid decreased 71.27 9.47 32 271299 410 90356706
Female genital tract fistula 71.02 9.47 162 271169 17706 90339410
Affect lability 70.94 9.47 163 271168 17900 90339216
Liver disorder 69.60 9.47 163 271168 121106 90236010
Drug abuse 68.97 9.47 87 271244 82260 90274856
Vitamin B1 decreased 68.27 9.47 33 271298 505 90356611
Road traffic accident 68.11 9.47 137 271194 107489 90249627
Sinus bradycardia 67.71 9.47 154 271177 16798 90340318
Influenza 67.26 9.47 675 270656 138589 90218527
Bradycardia 66.11 9.47 454 270877 83393 90273723
Cardiac output increased 65.32 9.47 32 271299 505 90356611
Taste disorder 65.25 9.47 53 271278 61493 90295623
Vaginal discharge 65.03 9.47 165 271166 19299 90337817
Chest discomfort 64.12 9.47 665 270666 137700 90219416
Diabetes mellitus 64.03 9.47 372 270959 64503 90292613
Pulmonary fibrosis 63.72 9.47 142 271189 107361 90249755
Pain of skin 63.02 9.47 145 271186 15937 90341179
Hepatic steatosis 62.89 9.47 248 271083 36697 90320419
Hyperhidrosis 62.17 9.47 653 270678 135652 90221464
Respiratory tract congestion 62.05 9.47 202 271129 27208 90329908
Inflammation 62.00 9.47 299 271032 178293 90178823
Coeliac disease 61.83 9.47 28 271303 44582 90312534
Influenza like illness 60.93 9.47 432 270899 80179 90276937
Pneumonia aspiration 60.40 9.47 263 271068 40677 90316439
Heart rate increased 60.32 9.47 559 270772 112343 90244773
Myelosuppression 59.55 9.47 44 271287 53547 90303569
Haematochezia 58.92 9.47 389 270942 70524 90286592
Exostosis 58.55 9.47 44 271287 53090 90304026
Delirium 58.51 9.47 142 271189 104217 90252899
Anxiety 57.51 9.47 1272 270059 308500 90048616
Febrile neutropenia 57.38 9.47 261 271070 158088 90199028
Lupus-like syndrome 57.05 9.47 38 271293 48808 90308308
Disturbance in attention 56.56 9.47 285 271046 46824 90310292
Angina unstable 56.47 9.47 87 271244 7056 90350060
Tinnitus 56.22 9.47 267 271064 42835 90314281
Blindness 55.88 9.47 191 271140 26377 90330739
Electrocardiogram abnormal 55.74 9.47 106 271225 10192 90346924
Atrioventricular block first degree 55.51 9.47 95 271236 8416 90348700
Conjoined twins 53.96 9.47 28 271303 502 90356614
Finger deformity 53.42 9.47 16 271315 32881 90324235
Dry skin 53.21 9.47 448 270883 87625 90269491
Recalled product 52.48 9.47 39 271292 1349 90355767
Heart rate irregular 52.39 9.47 176 271155 24092 90333024
Diplopia 52.35 9.47 197 271134 28517 90328599
Back injury 52.16 9.47 38 271293 46584 90310532
Hypertensive emergency 51.64 9.47 47 271284 2170 90354946
Oedema peripheral 51.05 9.47 1069 270262 256846 90100270
Product complaint 51.02 9.47 120 271211 13380 90343736
Nasopharyngitis 50.78 9.47 885 270446 406219 89950897
Somnolence 50.73 9.47 894 270437 208190 90148926
Hypoaesthesia 50.59 9.47 650 270681 313560 90043556
Dry mouth 49.91 9.47 334 270997 183725 90173391
Laryngitis 49.82 9.47 47 271284 50706 90306410
Peripheral swelling 49.01 9.47 906 270425 412200 89944916
Oral candidiasis 47.97 9.47 222 271109 35233 90321883
Weight decreased 47.56 9.47 1481 269850 378429 89978687
Gastrointestinal disorder 47.48 9.47 515 270816 256172 90100944
Blood pressure decreased 47.40 9.47 385 270946 74510 90282606
Lip swelling 47.35 9.47 235 271096 38375 90318741
Myalgia 47.30 9.47 762 270569 174363 90182753
Back pain 47.29 9.47 1264 270067 315911 90041205
Disability 47.18 9.47 32 271299 40713 90316403
Foetal death 47.08 9.47 4 271327 20719 90336397
Red blood cell sedimentation rate abnormal 46.84 9.47 8 271323 24196 90332920
Procedural pain 46.71 9.47 211 271120 33149 90323967
Intestinal angioedema 46.63 9.47 30 271301 818 90356298
Arrhythmia 46.60 9.47 250 271081 42082 90315034
Drug hypersensitivity 46.60 9.47 1045 270286 462564 89894552
Neutrophilia 46.56 9.47 71 271260 5707 90351409
Contusion 46.47 9.47 504 270827 250712 90106404
Blood creatine phosphokinase increased 46.01 9.47 213 271118 33810 90323306
Heart rate decreased 45.97 9.47 296 271035 53209 90303907
Hyperglycaemia 45.67 9.47 285 271046 50685 90306431
Ventricular tachycardia 45.45 9.47 170 271161 24538 90332578
Coma 45.23 9.47 372 270959 72260 90284856
Large intestine polyp 45.22 9.47 92 271239 9294 90347822
Hepatic cirrhosis 44.93 9.47 75 271256 63178 90293938
Product prescribing error 44.73 9.47 194 271137 29951 90327165
Diarrhoea 44.71 9.47 3325 268006 935865 89421251
Hypomagnesaemia 44.64 9.47 218 271113 35370 90321746
Mental status changes 44.61 9.47 257 271074 44422 90312694
Intentional self-injury 44.59 9.47 16 271315 29318 90327798
Adverse drug reaction 44.31 9.47 189 271142 116512 90240604
Obstructive airways disorder 44.31 9.47 174 271157 25695 90331421
Milk-alkali syndrome 44.22 9.47 34 271297 1239 90355877
Death 44.22 9.47 1035 270296 455516 89901600
Pemphigoid 44.11 9.47 89 271242 8937 90348179
Drug resistance 43.97 9.47 18 271313 30431 90326685
Cystitis 43.88 9.47 346 270985 66372 90290744
Drug-induced liver injury 43.78 9.47 132 271199 90186 90266930
Diabetes mellitus inadequate control 43.47 9.47 139 271192 18545 90338571
Arteriosclerosis 42.69 9.47 98 271233 10755 90346361
Eye pruritus 42.46 9.47 186 271145 28841 90328275
Knee arthroplasty 42.19 9.47 119 271212 83063 90274053
Dysgeusia 41.67 9.47 285 271046 52275 90304841
Hyperlipidaemia 41.59 9.47 157 271174 22759 90334357
Disease progression 41.56 9.47 286 271045 156329 90200787
General physical health deterioration 41.12 9.47 782 270549 354333 90002783
Ulcer haemorrhage 40.62 9.47 14 271317 26307 90330809
Normal newborn 40.50 9.47 10 271321 23352 90333764
Adverse event 40.50 9.47 197 271134 117221 90239895
Muscle twitching 40.01 9.47 161 271170 24041 90333075
Malignant neoplasm progression 40.01 9.47 174 271157 106696 90250420
Product monitoring error 39.71 9.47 58 271273 4486 90352630
Hepatic function abnormal 39.70 9.47 48 271283 46240 90310876
Cytomegalovirus infection 39.61 9.47 15 271316 26587 90330529
Blood chloride decreased 39.21 9.47 69 271262 6250 90350866
Tendon rupture 39.20 9.47 86 271245 9157 90347959
Rash papular 39.08 9.47 142 271189 20213 90336903
Gastric disorder 38.70 9.47 200 271131 33184 90323932
Onychomycosis 38.62 9.47 33 271298 37343 90319773
Hypophagia 38.05 9.47 210 271121 35727 90321389
Adverse reaction 37.65 9.47 21 271310 29691 90327425
Vasculitis 37.55 9.47 151 271180 22542 90334574
Product substitution issue 37.47 9.47 129 271202 17879 90339237
Cardiac disorder 37.43 9.47 295 271036 56577 90300539
Dementia 37.29 9.47 156 271175 23705 90333411
Foot deformity 36.83 9.47 77 271254 59574 90297542
Stupor 36.82 9.47 62 271269 5420 90351696
Weight increased 36.77 9.47 961 270370 416966 89940150
Premature delivery 36.77 9.47 37 271294 38725 90318391
Cutaneous lupus erythematosus 36.70 9.47 46 271285 3072 90354044
Allergic oedema 36.61 9.47 27 271304 923 90356193
Anti-neutrophil cytoplasmic antibody positive vasculitis 36.40 9.47 52 271279 3941 90353175
Chest pain 36.08 9.47 1231 270100 318414 90038702
Ventricular fibrillation 35.94 9.47 108 271223 13936 90343180
Walking aid user 35.89 9.47 32 271299 35474 90321642
Blood cholesterol decreased 35.62 9.47 36 271295 1895 90355221
Hip fracture 35.50 9.47 194 271137 32883 90324233
Vitamin B1 increased 35.43 9.47 15 271316 165 90356951
Infusion site reaction 35.33 9.47 7 271324 19032 90338084
Constipation 35.31 9.47 1094 270237 279301 90077815
Ventricular hypertrophy 35.18 9.47 47 271284 3344 90353772
Tremor 35.04 9.47 649 270682 152524 90204592
Deep vein thrombosis 35.00 9.47 424 270907 91196 90265920
Ventricular extrasystoles 34.96 9.47 103 271228 13147 90343969
Hospitalisation 34.95 9.47 232 271099 127868 90229248
Gastrooesophageal reflux disease 34.73 9.47 695 270636 165642 90191474
Diverticulum 34.71 9.47 97 271234 12016 90345100
Basal cell carcinoma 34.61 9.47 194 271137 33195 90323921
Nail disorder 34.20 9.47 79 271252 58988 90298128
Abnormal dreams 34.10 9.47 92 271239 11165 90345951
Intervertebral disc protrusion 33.68 9.47 166 271165 27030 90330086
Systemic infection 33.40 9.47 55 271276 4720 90352396
Swollen tongue 33.40 9.47 244 271087 45712 90311404
Seronegative arthritis 33.22 9.47 7 271324 18227 90338889
Device related thrombosis 33.21 9.47 36 271295 2057 90355059
Malaise 33.14 9.47 2105 269226 583881 89773235
Rotator cuff syndrome 33.09 9.47 114 271217 15805 90341311
Withdrawal hypertension 32.99 9.47 14 271317 155 90356961
Visual acuity reduced 32.73 9.47 148 271183 23262 90333854
Dysuria 32.64 9.47 216 271115 39185 90317931
Prescribed underdose 32.64 9.47 115 271216 74904 90282212
Temperature regulation disorder 32.62 9.47 3 271328 14576 90342540
Vertigo 32.55 9.47 336 270995 69475 90287641
Haemophagocytic lymphohistiocytosis 32.49 9.47 4 271327 15455 90341661
Ear infection 32.38 9.47 104 271227 69671 90287445
Headache 32.31 9.47 3000 268331 859746 89497370
Neutrophil count decreased 32.24 9.47 108 271223 71424 90285692
Hyperlactacidaemia 32.17 9.47 50 271281 4086 90353030
Rhinorrhoea 32.13 9.47 405 270926 87911 90269205
Nervousness 32.13 9.47 193 271138 33863 90323253
Essential hypertension 31.74 9.47 63 271268 6252 90350864
Congenital bladder anomaly 31.72 9.47 15 271316 218 90356898
Electrolyte imbalance 31.62 9.47 148 271183 23597 90333519
Peripheral circulatory failure 31.62 9.47 31 271300 1573 90355543
Emotional distress 31.60 9.47 203 271128 36459 90320657
Hypocalcaemia 31.39 9.47 226 271105 42142 90314974
Parkinsonism 31.25 9.47 103 271228 13962 90343154
Urachal abnormality 31.24 9.47 15 271316 226 90356890
Respiratory disorder 31.22 9.47 95 271236 64721 90292395
Dermatitis atopic 31.04 9.47 146 271185 23326 90333790
Cytokine release syndrome 31.03 9.47 23 271308 27950 90329166
Breath sounds abnormal 30.96 9.47 109 271222 15277 90341839
Choroidal infarction 30.76 9.47 12 271319 105 90357011
Migraine 30.56 9.47 394 270937 189998 90167118
Persistent cloaca 30.49 9.47 15 271316 239 90356877
Musculoskeletal pain 30.30 9.47 347 270984 170904 90186212
Subacute cutaneous lupus erythematosus 30.26 9.47 45 271286 3537 90353579
Eosinophil count increased 30.15 9.47 97 271234 12984 90344132
Urinary incontinence 29.96 9.47 204 271127 37362 90319754
Neutropenia 29.94 9.47 483 270848 224421 90132695
Psoriasis 29.73 9.47 614 270717 147140 90209976
Supraventricular extrasystoles 29.56 9.47 55 271276 5202 90351914
Acute coronary syndrome 29.43 9.47 85 271246 10728 90346388
Pneumonia 29.42 9.47 1586 269745 636473 89720643
Respiratory tract inflammation 29.40 9.47 20 271311 600 90356516
Joint destruction 29.03 9.47 3 271328 13284 90343832
Mitral valve incompetence 28.99 9.47 139 271192 22385 90334731
Diverticulitis 28.97 9.47 233 271098 44954 90312162
Erythrodermic psoriasis 28.85 9.47 25 271306 1081 90356035
Acute myocardial infarction 28.74 9.47 191 271140 34699 90322417
Vision blurred 28.69 9.47 477 270854 109816 90247300
Leukopenia 28.69 9.47 180 271151 100530 90256586
Neuroglycopenia 28.68 9.47 25 271306 1090 90356026
Renal impairment 28.56 9.47 459 270872 104962 90252154
Anhedonia 28.40 9.47 87 271244 11344 90345772
Immunodeficiency 28.24 9.47 54 271277 43180 90313936
Colitis 28.18 9.47 327 271004 69615 90287501
Haemodialysis 28.03 9.47 73 271258 8674 90348442
Hypersensitivity vasculitis 27.88 9.47 47 271284 4112 90353004
Intestinal malrotation 27.59 9.47 17 271314 429 90356687
Anaemia 27.56 9.47 1306 270025 351496 90005620
Sleep apnoea syndrome 27.50 9.47 176 271155 31571 90325545
Arthritis 27.31 9.47 675 270656 166640 90190476
Sinusitis 27.30 9.47 800 270531 342288 90014828
Micturition disorder 27.05 9.47 39 271292 2981 90354135
Coronary artery occlusion 27.01 9.47 71 271260 8483 90348633
Acute myeloid leukaemia 27.01 9.47 14 271317 20626 90336490
Bacterial infection 26.86 9.47 140 271191 23304 90333812
Pustular psoriasis 26.74 9.47 11 271320 18545 90338571
Non-cardiogenic pulmonary oedema 26.67 9.47 25 271306 1199 90355917
Carotid artery stenosis 26.55 9.47 53 271278 5281 90351835
Orthostatic hypotension 26.45 9.47 215 271116 41612 90315504
Pathological fracture 26.35 9.47 76 271255 9584 90347532
Peripheral vascular disorder 26.33 9.47 59 271272 6372 90350744
Cerebellar syndrome 26.28 9.47 44 271287 3828 90353288
Haematoma muscle 26.22 9.47 30 271301 1820 90355296
Neurosensory hypoacusis 26.05 9.47 13 271318 214 90356902
Photosensitivity reaction 25.96 9.47 114 271217 17693 90339423
Therapy partial responder 25.94 9.47 17 271314 22026 90335090
Coronary artery stenosis 25.83 9.47 52 271279 5214 90351902
Hot flush 25.72 9.47 282 271049 59206 90297910
Bladder prolapse 25.70 9.47 32 271299 2123 90354993
Intestinal villi atrophy 25.58 9.47 15 271316 345 90356771
Blood creatine increased 25.32 9.47 61 271270 6906 90350210
Drug tolerance 25.21 9.47 11 271320 17905 90339211
Choroidal effusion 25.09 9.47 20 271311 769 90356347
Device expulsion 25.05 9.47 53 271278 40833 90316283
Pollakiuria 25.00 9.47 177 271154 32828 90324288
Muscle spasticity 24.79 9.47 186 271145 35136 90321980
Rhinalgia 24.76 9.47 34 271297 2484 90354632
Nephrocalcinosis 24.64 9.47 24 271307 1208 90355908
Myocardial ischaemia 24.54 9.47 94 271237 13720 90343396
Orthostatic intolerance 24.54 9.47 25 271306 1329 90355787
Osteonecrosis 24.30 9.47 148 271183 26093 90331023
Chills 24.15 9.47 541 270790 131440 90225676
Cholelithiasis 24.14 9.47 252 271079 52254 90304862
Chronic kidney disease 24.08 9.47 243 271088 49948 90307168
Rectal haemorrhage 23.83 9.47 364 270967 82380 90274736
Atrioventricular block 23.71 9.47 69 271262 8746 90348370
Foetal exposure during pregnancy 23.67 9.47 59 271272 42916 90314200
Forced vital capacity decreased 23.66 9.47 23 271308 1155 90355961
Ear injury 23.57 9.47 14 271317 330 90356786
Skin discolouration 23.45 9.47 219 271112 44096 90313020
Renal tubular necrosis 23.41 9.47 96 271235 14459 90342657
Electrocardiogram ST segment depression 23.05 9.47 38 271293 3265 90353851
Bronchomalacia 23.03 9.47 12 271319 217 90356899
Schizophrenia 22.90 9.47 8 271323 14906 90342210
Adenocarcinoma 22.61 9.47 37 271294 3159 90353957
BRASH syndrome 22.56 9.47 28 271303 1851 90355265
Bundle branch block left 22.45 9.47 63 271268 7822 90349294
Renal artery stenosis 22.32 9.47 30 271301 2147 90354969
General symptom 22.29 9.47 8 271323 14660 90342456
Drug ineffective for unapproved indication 22.29 9.47 113 271218 66531 90290585
Angle closure glaucoma 22.22 9.47 34 271297 2741 90354375
Hiatus hernia 22.21 9.47 141 271190 25220 90331896
Eosinophilia 22.19 9.47 154 271177 28379 90328737
Oropharyngeal swelling 22.07 9.47 20 271311 918 90356198
Pancreatitis 22.00 9.47 312 271019 69514 90287602
Incorrect route of product administration 21.76 9.47 78 271253 50548 90306568
Bone abscess 21.73 9.47 15 271316 461 90356655
Tooth abscess 21.64 9.47 102 271229 16311 90340805
Neurofibrosarcoma 21.62 9.47 11 271320 189 90356927
Myopathy 21.61 9.47 89 271242 13429 90343687
Stress 21.53 9.47 353 270978 81042 90276074
Hepatotoxicity 21.50 9.47 68 271263 45774 90311342
Gastritis 21.42 9.47 205 271126 41548 90315568
Hypertension 21.19 9.47 1617 269714 455915 89901201
Maternal exposure before pregnancy 21.06 9.47 4 271327 11209 90345907
Thrombocytopenia 21.06 9.47 470 270861 208255 90148861
Spinal osteoarthritis 21.02 9.47 113 271218 19035 90338081
Fear 20.97 9.47 102 271229 16520 90340596
Tooth erosion 20.88 9.47 15 271316 492 90356624
Deafness 20.86 9.47 127 271204 22387 90334729
Cutaneous T-cell lymphoma 20.85 9.47 25 271306 1595 90355521
Distributive shock 20.74 9.47 37 271294 3387 90353729
Glycosylated haemoglobin increased 20.73 9.47 97 271234 15465 90341651
Lichen planus 20.68 9.47 33 271298 2758 90354358
Hallucination 20.50 9.47 294 271037 65665 90291451
Gastric polyps 20.41 9.47 44 271287 4628 90352488
Pneumothorax spontaneous 20.01 9.47 19 271312 926 90356190
Injection site extravasation 19.99 9.47 66 271265 8953 90348163
Eosinophilic cellulitis 19.86 9.47 11 271320 226 90356890
Meniscus injury 19.82 9.47 62 271269 8175 90348941
Metabolic alkalosis 19.79 9.47 37 271294 3512 90353604
Blood pressure fluctuation 19.77 9.47 242 271089 52171 90304945
Torsade de pointes 19.76 9.47 94 271237 15088 90342028
Cyanopsia 19.72 9.47 5 271326 7 90357109
Vulvovaginal burning sensation 19.67 9.47 31 271300 2564 90354552
Initial insomnia 19.64 9.47 67 271264 9243 90347873
Azotaemia 19.63 9.47 47 271284 5301 90351815
Jaw disorder 19.49 9.47 48 271283 5511 90351605
Petechiae 19.44 9.47 96 271235 15645 90341471
Left ventricular hypertrophy 19.41 9.47 51 271280 6093 90351023
Hypertensive angiopathy 19.40 9.47 8 271323 82 90357034
Injection site reaction 19.39 9.47 179 271152 91901 90265215
Body height decreased 19.36 9.47 79 271252 11870 90345246
Hypertensive heart disease 19.27 9.47 31 271300 2609 90354507
Pharyngeal oedema 19.20 9.47 87 271244 13684 90343432
Small cell carcinoma 19.09 9.47 10 271321 183 90356933
Intentional overdose 19.08 9.47 184 271147 93650 90263466
Meniere's disease 19.04 9.47 10 271321 184 90356932
Renal cyst 18.95 9.47 83 271248 12867 90344249
Overdose 18.94 9.47 345 270986 157364 90199752
Melaena 18.93 9.47 173 271158 34624 90322492
Parathyroid disorder 18.88 9.47 17 271314 774 90356342
Suicide attempt 18.87 9.47 140 271191 75259 90281857
Endometrial cancer stage I 18.83 9.47 11 271320 251 90356865
Hypoparathyroidism secondary 18.82 9.47 7 271324 53 90357063
Blood pressure systolic abnormal 18.77 9.47 111 271220 19367 90337749
Urinary tract infection 18.74 9.47 1106 270225 304526 90052590
Ischaemic stroke 18.65 9.47 122 271209 22044 90335072
Polymyalgia rheumatica 18.55 9.47 44 271287 4933 90352183
Prerenal failure 18.49 9.47 27 271304 2088 90355028
Upper-airway cough syndrome 18.47 9.47 92 271239 15043 90342073
Product administration error 18.46 9.47 139 271192 26284 90330832
Cardiac stress test abnormal 18.41 9.47 15 271316 595 90356521
Blood pressure abnormal 18.32 9.47 111 271220 19534 90337582
Hyperlipasaemia 18.16 9.47 17 271314 814 90356302
Noninfective gingivitis 18.12 9.47 27 271304 2126 90354990
Multiple drug therapy 18.03 9.47 54 271277 6955 90350161
Rebound tachycardia 17.99 9.47 5 271326 12 90357104
Metastases to fallopian tube 17.87 9.47 7 271324 62 90357054
International normalised ratio decreased 17.86 9.47 42 271289 4682 90352434
Injection site inflammation 17.86 9.47 41 271290 4500 90352616
Cardiomegaly 17.69 9.47 107 271224 18818 90338298
Muscular weakness 17.63 9.47 772 270559 205894 90151222
Gout 17.50 9.47 98 271233 16761 90340355
Non-cardiac chest pain 17.49 9.47 52 271279 6669 90350447
Vascular device infection 17.36 9.47 7 271324 11945 90345171
Blood potassium increased 17.34 9.47 114 271217 20635 90336481
Gallbladder disorder 17.28 9.47 110 271221 19693 90337423
Hypoparathyroidism 17.27 9.47 18 271313 983 90356133
Hyponatraemic encephalopathy 17.26 9.47 11 271320 295 90356821
Completed suicide 16.94 9.47 561 270770 144497 90212619
Oesophageal discomfort 16.93 9.47 11 271320 305 90356811
Renal injury 16.82 9.47 68 271263 10175 90346941
Confabulation 16.81 9.47 11 271320 309 90356807
Joint ankylosis 16.59 9.47 20 271311 1283 90355833
Mucosal membrane hyperplasia 16.53 9.47 6 271325 42 90357074
Cardiac hypertrophy 16.52 9.47 19 271312 1159 90355957
Gastrointestinal toxicity 16.51 9.47 4 271327 9463 90347653
Joint dislocation 16.43 9.47 73 271258 44509 90312607
Mandibular mass 16.38 9.47 9 271322 182 90356934
Macrocytosis 16.34 9.47 30 271301 2808 90354308
Aphthous ulcer 16.33 9.47 98 271233 17189 90339927
Coronary ostial stenosis 16.30 9.47 7 271324 80 90357036
Carotid bruit 16.29 9.47 15 271316 703 90356413
Atrioventricular block second degree 16.20 9.47 39 271292 4413 90352703
Cytopenia 16.16 9.47 17 271314 17432 90339684
Lacunar infarction 16.15 9.47 33 271298 3344 90353772
Product residue present 16.06 9.47 38 271293 4253 90352863
Flatulence 16.04 9.47 192 271139 41175 90315941
Bronchopulmonary aspergillosis 16.04 9.47 7 271324 11391 90345725
Bundle branch block right 15.95 9.47 44 271287 5409 90351707
Crystal arthropathy 15.88 9.47 11 271320 340 90356776
Tubulointerstitial nephritis 15.88 9.47 130 271201 25213 90331903
Pernicious anaemia 15.87 9.47 16 271315 840 90356276
Femur fracture 15.78 9.47 209 271122 45873 90311243
Macular oedema 15.76 9.47 41 271290 4868 90352248
Blood creatinine abnormal 15.76 9.47 37 271294 4120 90352996
Rectal prolapse 15.71 9.47 26 271305 2241 90354875
Haematotoxicity 15.68 9.47 9 271322 12526 90344590
International normalised ratio increased 15.55 9.47 213 271118 47103 90310013
Ultrasound kidney abnormal 15.53 9.47 6 271325 51 90357065
Dilatation atrial 15.48 9.47 24 271307 1957 90355159
Blood pressure diastolic increased 15.43 9.47 78 271253 12828 90344288
Body temperature decreased 15.37 9.47 123 271208 23693 90333423
Cerebral ischaemia 15.37 9.47 52 271279 7144 90349972
Neutropenic sepsis 15.34 9.47 19 271312 18111 90339005
Polydipsia 15.33 9.47 37 271294 4194 90352922
Erythema 15.29 9.47 836 270495 228410 90128706
Eosinophilia myalgia syndrome 15.23 9.47 4 271327 7 90357109
Therapeutic response unexpected 15.23 9.47 115 271216 21765 90335351
Nocturia 15.22 9.47 66 271265 10189 90346927
Mesenteric panniculitis 15.19 9.47 9 271322 211 90356905
Dyspnoea 15.18 9.47 2924 268407 878031 89479085
Red blood cell sedimentation rate increased 15.14 9.47 166 271165 82429 90274687
Carpal tunnel syndrome 15.13 9.47 123 271208 23805 90333311
Epstein-Barr virus infection 15.12 9.47 6 271325 10338 90346778
Gastroenteritis clostridial 15.12 9.47 14 271317 661 90356455
Ageusia 15.10 9.47 91 271240 15985 90341131
Face injury 15.07 9.47 35 271296 3870 90353246
Actinic keratosis 15.06 9.47 31 271300 3157 90353959
Sopor 15.05 9.47 32 271299 24612 90332504
Cortisol free urine increased 15.04 9.47 6 271325 56 90357060
Chondropathy 15.03 9.47 27 271304 2485 90354631
Pulpitis dental 15.02 9.47 17 271314 1019 90356097
Thrombotic microangiopathy 14.96 9.47 15 271316 15728 90341388
Micturition urgency 14.95 9.47 70 271261 11163 90345953
Extrasystoles 14.95 9.47 44 271287 5613 90351503
Vascular purpura 14.92 9.47 22 271309 1716 90355400
Metabolic acidosis 14.92 9.47 242 271089 55434 90301682
Chronic obstructive pulmonary disease 14.91 9.47 307 271024 73522 90283594
Haemorrhagic fever 14.89 9.47 4 271327 8 90357108
Foreign body in reproductive tract 14.88 9.47 18 271313 1159 90355957
Drug clearance decreased 14.84 9.47 23 271308 1875 90355241
Transplant rejection 14.80 9.47 10 271321 12748 90344368
Osmotic demyelination syndrome 14.79 9.47 17 271314 1037 90356079
Blood hyposmosis 14.72 9.47 5 271326 28 90357088
Shock haemorrhagic 14.64 9.47 74 271257 12171 90344945
Staphylococcal abscess 14.64 9.47 15 271316 803 90356313
Cerebellar cognitive affective syndrome 14.57 9.47 4 271327 9 90357107
Vulvovaginal pruritus 14.55 9.47 35 271296 3958 90353158
Pain 14.52 9.47 2695 268636 993646 89363470
Acute myopia 14.46 9.47 8 271323 164 90356952
B-cell lymphoma stage I 14.44 9.47 3 271328 0 90357116
Renal artery dissection 14.44 9.47 3 271328 0 90357116
Haematocrit decreased 14.44 9.47 190 271141 41642 90315474
Low density lipoprotein increased 14.35 9.47 55 271276 8030 90349086
Post-anoxic myoclonus 14.29 9.47 5 271326 31 90357085
Squamous cell carcinoma 14.22 9.47 64 271267 10037 90347079
Spondylitis 14.07 9.47 13 271318 14165 90342951
Lipohypertrophy 14.04 9.47 14 271317 725 90356391
Product commingling 13.92 9.47 8 271323 177 90356939
Injection site hypersensitivity 13.74 9.47 27 271304 2660 90354456
Procalcitonin increased 13.72 9.47 20 271311 1544 90355572
Large intestinal polypectomy 13.71 9.47 10 271321 336 90356780
Polyuria 13.68 9.47 63 271268 9977 90347139
Lipoedema 13.63 9.47 10 271321 339 90356777
Premature labour 13.59 9.47 12 271319 13364 90343752
Pyrexia 13.58 9.47 1751 269580 658734 89698382
Glomerulonephritis rapidly progressive 13.57 9.47 18 271313 1272 90355844
Breast neoplasm 13.57 9.47 20 271311 1560 90355556
Allergic hepatitis 13.54 9.47 5 271326 37 90357079
Endometrial cancer 13.53 9.47 32 271299 3580 90353536
Anaemia postoperative 13.52 9.47 24 271307 2189 90354927
Coronavirus test positive 13.52 9.47 15 271316 880 90356236
Epistaxis 13.46 9.47 342 270989 84783 90272333
Vomiting 13.42 9.47 2615 268716 785678 89571438
Hypertrophic cardiomyopathy 13.40 9.47 24 271307 2204 90354912
Thrombosis 13.31 9.47 300 271031 72951 90284165
Increased appetite 13.30 9.47 70 271261 11695 90345421
Osteogenesis imperfecta 13.18 9.47 15 271316 905 90356211
Lip infection 13.18 9.47 7 271324 132 90356984
Cardiac valve disease 13.16 9.47 37 271294 4598 90352518
Wound treatment 13.16 9.47 8 271323 197 90356919
Injection site discolouration 13.08 9.47 59 271272 9261 90347855
Renin increased 13.08 9.47 8 271323 199 90356917
Sedation complication 13.07 9.47 19 271312 16925 90340191
Hyponatraemic syndrome 13.04 9.47 12 271319 562 90356554
Procedural complication 13.02 9.47 43 271288 5835 90351281
Neonatal respiratory distress 13.00 9.47 13 271318 676 90356440
Haematoma 12.92 9.47 176 271155 38872 90318244
Gastritis erosive 12.86 9.47 47 271284 6708 90350408
Emphysema 12.85 9.47 71 271260 12084 90345032
Endometrial disorder 12.81 9.47 14 271317 807 90356309
Gastric ulcer haemorrhage 12.80 9.47 40 271291 5271 90351845
Nodal rhythm 12.80 9.47 21 271310 1797 90355319
Adenomatous polyposis coli 12.76 9.47 7 271324 141 90356975
Epileptic encephalopathy 12.67 9.47 10 271321 379 90356737
Swelling face 12.61 9.47 326 271005 81026 90276090
Pituitary apoplexy 12.59 9.47 7 271324 145 90356971
Rheumatoid arthritis 12.56 9.47 925 270406 361689 89995427
Platelet count decreased 12.54 9.47 313 271018 136656 90220460
Rash vesicular 12.53 9.47 22 271309 18175 90338941
Diabetic neuropathy 12.49 9.47 36 271295 4538 90352578
Tanning 12.46 9.47 6 271325 91 90357025
Haemarthrosis 12.46 9.47 33 271298 3961 90353155
Endometrial hyperplasia 12.42 9.47 15 271316 964 90356152
Gastroenteritis 12.38 9.47 138 271193 29091 90328025
Gastric atony 12.37 9.47 3 271328 3 90357113
Osteomyelitis acute 12.35 9.47 9 271322 302 90356814
Bone marrow failure 12.34 9.47 52 271279 32169 90324947
Joint stiffness 12.33 9.47 162 271169 77880 90279236
Cardiac murmur 12.31 9.47 95 271236 18099 90339017
Spinal cord disorder 12.29 9.47 19 271312 1546 90355570
Adiposis dolorosa 12.27 9.47 9 271322 305 90356811
Kyphosis 12.27 9.47 27 271304 2881 90354235
Multiple-drug resistance 12.24 9.47 4 271327 7772 90349344
Oral fibroma 12.23 9.47 5 271326 50 90357066
Rheumatoid factor 12.17 9.47 11 271320 503 90356613
Injection site hypertrophy 12.17 9.47 6 271325 96 90357020
Dementia Alzheimer's type 12.15 9.47 15 271316 986 90356130
Cutaneous T-cell lymphoma stage I 12.15 9.47 4 271327 20 90357096
Renal phospholipidosis 12.12 9.47 8 271323 228 90356888
Neonatal anuria 12.06 9.47 5 271326 52 90357064
Pruritus allergic 12.05 9.47 20 271311 1728 90355388
Blood parathyroid hormone decreased 12.02 9.47 70 271261 12146 90344970
Delayed fontanelle closure 11.99 9.47 4 271327 21 90357095
Urea renal clearance decreased 11.99 9.47 4 271327 21 90357095
Varicose vein ruptured 11.98 9.47 5 271326 53 90357063
Iodine allergy 11.94 9.47 14 271317 872 90356244
Nodal arrhythmia 11.93 9.47 17 271314 1286 90355830
Unintended pregnancy 11.89 9.47 4 271327 7633 90349483
Dystonia 11.89 9.47 20 271311 16799 90340317
Burning sensation 11.89 9.47 261 271070 63191 90293925
Alkalosis hypochloraemic 11.88 9.47 8 271323 236 90356880
Sensory disturbance 11.87 9.47 83 271248 15330 90341786
Prothrombin time abnormal 11.85 9.47 11 271320 521 90356595
Carcinoid tumour 11.85 9.47 10 271321 417 90356699
Oesophageal oedema 11.81 9.47 5 271326 55 90357061
Adrenocortical carcinoma 11.81 9.47 5 271326 55 90357061
Food allergy 11.80 9.47 38 271293 25440 90331676
Comminuted fracture 11.76 9.47 11 271320 526 90356590
Coronary artery restenosis 11.75 9.47 9 271322 326 90356790
Blood potassium abnormal 11.74 9.47 27 271304 2967 90354149
Skin ulcer 11.73 9.47 213 271118 49862 90307254
Aspiration 11.72 9.47 18 271313 15675 90341441
Renovascular hypertension 11.69 9.47 4 271327 23 90357093
Tricuspid valve incompetence 11.68 9.47 88 271243 16643 90340473
Pneumocystis jirovecii pneumonia 11.65 9.47 30 271301 21586 90335530
Intervertebral disc degeneration 11.58 9.47 90 271241 17184 90339932
Sinus pain 11.56 9.47 39 271292 5350 90351766
Congestive hepatopathy 11.50 9.47 27 271304 3006 90354110
Graft versus host disease 11.46 9.47 5 271326 8139 90348977
Malignant hypertension 11.42 9.47 16 271315 1191 90355925
Cell death 11.37 9.47 27 271304 3028 90354088
Thyroid neoplasm 11.32 9.47 32 271299 3989 90353127
Encephalomalacia 11.32 9.47 11 271320 552 90356564
Laryngeal pain 11.31 9.47 34 271297 4388 90352728
Anaphylactic reaction 11.29 9.47 189 271142 87335 90269781
Poisoning deliberate 11.29 9.47 20 271311 16466 90340650
Microalbuminuria 11.29 9.47 11 271320 554 90356562
Chromaturia 11.27 9.47 97 271234 19090 90338026
Polycythaemia 11.26 9.47 16 271315 1207 90355909
Interstitial lung disease 11.21 9.47 161 271170 76244 90280872
Rash pruritic 11.20 9.47 324 271007 81890 90275226
Peptic ulcer 11.20 9.47 39 271292 5436 90351680
Good syndrome 11.17 9.47 3 271328 6 90357110
Lipase increased 11.15 9.47 64 271267 11047 90346069
Skin pressure mark 11.15 9.47 4 271327 27 90357089
Pseudomonas infection 11.15 9.47 17 271314 14848 90342268
Monoparesis 11.14 9.47 21 271310 2006 90355110
Breast pain 11.11 9.47 61 271270 10357 90346759
Skin laceration 11.06 9.47 123 271208 25912 90331204
Blood glucose decreased 11.03 9.47 113 271218 23316 90333800
Cold sweat 10.95 9.47 76 271255 14005 90343111
Hypotonia 10.94 9.47 65 271266 11361 90345755
Early satiety 10.93 9.47 17 271314 1390 90355726
Head injury 10.91 9.47 142 271189 31046 90326070
Device related infection 10.90 9.47 40 271291 25746 90331370
Aortic valve incompetence 10.90 9.47 44 271287 6580 90350536
Diverticulum oesophageal 10.81 9.47 7 271324 193 90356923
Coma acidotic 10.80 9.47 6 271325 124 90356992
Cholecystitis chronic 10.79 9.47 58 271273 9768 90347348
Antidiuretic hormone abnormality 10.79 9.47 4 271327 30 90357086
Allergic cough 10.74 9.47 15 271316 1113 90356003
Postural tremor 10.73 9.47 10 271321 476 90356640
Fluid intake reduced 10.69 9.47 32 271299 4120 90352996
Loss of consciousness 10.69 9.47 518 270813 139720 90217396
Hypoacusis 10.68 9.47 129 271202 27721 90329395
Wrong patient 10.66 9.47 13 271318 844 90356272
Restlessness 10.62 9.47 158 271173 35562 90321554
Arrhythmia supraventricular 10.60 9.47 15 271316 1127 90355989
Cardiovascular disorder 10.60 9.47 73 271258 13419 90343697
Oesophageal cancer metastatic 10.59 9.47 6 271325 129 90356987
Left atrial dilatation 10.57 9.47 20 271311 1916 90355200
Full blood count abnormal 10.54 9.47 161 271170 36436 90320680
Iatrogenic injury 10.53 9.47 13 271318 855 90356261
Device difficult to use 10.50 9.47 23 271308 17502 90339614
Glomerulonephritis 10.49 9.47 23 271308 2447 90354669
Eosinophil count decreased 10.49 9.47 27 271304 3185 90353931
Occult blood 10.41 9.47 16 271315 1295 90355821
Thermal burn 10.40 9.47 44 271287 6718 90350398
Granuloma skin 10.38 9.47 61 271270 10619 90346497
Lethargy 10.37 9.47 255 271076 62884 90294232
Speech disorder 10.36 9.47 193 271138 45392 90311724
Occult blood positive 10.35 9.47 31 271300 3992 90353124
Miliaria 10.34 9.47 17 271314 1457 90355659
Haematotympanum 10.31 9.47 3 271328 9 90357107
Iliac artery embolism 10.31 9.47 3 271328 9 90357107
Renal scan abnormal 10.31 9.47 3 271328 9 90357107
Tachycardia 10.31 9.47 574 270757 157099 90200017
Hypertrichosis 10.30 9.47 17 271314 1462 90355654
Thalamic infarction 10.29 9.47 10 271321 502 90356614
Circulatory collapse 10.28 9.47 117 271214 24787 90332329
Urine odour abnormal 10.28 9.47 46 271285 7198 90349918
Oral herpes 10.24 9.47 149 271182 33375 90323741
Tooth disorder 10.23 9.47 140 271191 30950 90326166
Blood glucose fluctuation 10.22 9.47 36 271295 5047 90352069
Communication disorder 10.20 9.47 27 271304 3239 90353877
Weight fluctuation 10.20 9.47 28 271303 19721 90337395
Cataract operation 10.19 9.47 41 271290 6122 90350994
Retinal depigmentation 10.18 9.47 8 271323 301 90356815
Serum serotonin increased 10.15 9.47 7 271324 215 90356901
Endophthalmitis 10.13 9.47 34 271297 4651 90352465
Pain in extremity 10.13 9.47 1517 269814 449012 89908104
Coronary artery bypass 10.12 9.47 22 271309 2327 90354789
Bladder transitional cell carcinoma 10.11 9.47 13 271318 891 90356225
Arteriosclerosis coronary artery 10.09 9.47 56 271275 9547 90347569
Activated partial thromboplastin time 10.07 9.47 3 271328 10 90357106
Diverticulum intestinal 10.07 9.47 54 271277 9088 90348028
Nerve compression 10.04 9.47 60 271271 10506 90346610
Bone loss 10.04 9.47 28 271303 3464 90353652
Application site vesicles 9.98 9.47 17 271314 1500 90355616
Neuromyopathy 9.97 9.47 12 271319 769 90356347
Eye swelling 9.95 9.47 133 271198 29253 90327863
Amaurosis fugax 9.93 9.47 11 271320 644 90356472
Intraductal papilloma of breast 9.89 9.47 7 271324 224 90356892
Progressive multifocal leukoencephalopathy 9.84 9.47 20 271311 15635 90341481
Renal neoplasm 9.82 9.47 17 271314 1520 90355596
Mass 9.81 9.47 80 271251 15497 90341619
Abdominal pain 9.80 9.47 1340 269991 394381 89962735
Urine output decreased 9.79 9.47 68 271263 12535 90344581
Non-Hodgkin's lymphoma 9.74 9.47 16 271315 1370 90355746
Agranulocytosis 9.74 9.47 63 271268 34939 90322177
Concomitant disease progression 9.73 9.47 21 271310 2211 90354905
Bundle branch block 9.72 9.47 13 271318 926 90356190
Flank pain 9.67 9.47 94 271237 19128 90337988
Metabolic encephalopathy 9.67 9.47 43 271288 6709 90350407
Metastases to bladder 9.65 9.47 7 271324 233 90356883
Enthesophyte 9.65 9.47 6 271325 154 90356962
Limb injury 9.61 9.47 140 271191 31368 90325748
Mantle cell lymphoma 9.61 9.47 11 271320 668 90356448
Mydriasis 9.59 9.47 19 271312 14993 90342123
Humerus fracture 9.58 9.47 56 271275 9729 90347387
Venoocclusive liver disease 9.58 9.47 3 271328 5990 90351126
Exposure to toxic agent 9.57 9.47 6 271325 7961 90349155
Breast calcifications 9.56 9.47 16 271315 1392 90355724
Product formulation issue 9.55 9.47 11 271320 672 90356444
Procedural hypertension 9.55 9.47 8 271323 330 90356786
Base excess decreased 9.52 9.47 5 271326 92 90357024
Gingival oedema 9.52 9.47 5 271326 92 90357024
Rhinovirus infection 9.50 9.47 3 271328 5960 90351156
Abortion induced 9.50 9.47 13 271318 11875 90345241

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 574.31 10.65 1139 142748 100323 42377125
Angioedema 411.54 10.65 606 143281 41871 42435577
Off label use 373.56 10.65 1024 142863 637311 41840137
Acute kidney injury 309.17 10.65 2208 141679 365129 42112319
Hypokalaemia 297.79 10.65 711 143176 71010 42406438
Syncope 183.71 10.65 743 143144 98663 42378785
Drug abuse 182.30 10.65 63 143824 104708 42372740
Dizziness 172.06 10.65 1432 142455 247822 42229626
Febrile neutropenia 162.85 10.65 234 143653 185469 42291979
Drug ineffective 157.88 10.65 1367 142520 628830 41848618
Neutropenia 142.93 10.65 286 143601 199145 42278303
Cerebrovascular accident 142.01 10.65 677 143210 96483 42380965
Product use in unapproved indication 137.85 10.65 258 143629 184198 42293250
Death 136.83 10.65 981 142906 470204 42007244
Blood glucose increased 134.62 10.65 549 143338 73150 42404298
Myocardial infarction 131.42 10.65 791 143096 123218 42354230
Pyrexia 127.01 10.65 795 143092 393247 42084201
Dehydration 123.72 10.65 861 143026 140906 42336542
Cardiospasm 120.54 10.65 77 143810 1830 42475618
Milk-alkali syndrome 116.82 10.65 54 143833 653 42476795
Hypotension 116.32 10.65 1355 142532 256276 42221172
Pneumonia 113.37 10.65 898 142989 421251 42056197
Carotid artery occlusion 109.67 10.65 100 143787 4094 42473354
Facial pain 108.33 10.65 100 143787 4160 42473288
Coronary artery disease 106.79 10.65 411 143476 53309 42424139
Palmoplantar keratoderma 106.53 10.65 76 143811 2178 42475270
Blood pressure increased 102.17 10.65 641 143246 101287 42376161
Pruritus genital 95.84 10.65 76 143811 2563 42474885
Vasculitis 90.30 10.65 195 143692 18199 42459249
Blood pressure inadequately controlled 90.29 10.65 76 143811 2792 42474656
Sleep terror 88.97 10.65 76 143811 2850 42474598
Tension headache 86.54 10.65 80 143807 3334 42474114
Atrial tachycardia 86.08 10.65 87 143800 4053 42473395
Pancreatitis acute 85.81 10.65 279 143608 33285 42444163
Lactic acidosis 84.86 10.65 340 143547 44921 42432527
Sepsis 83.15 10.65 368 143519 198966 42278482
Immunisation 82.52 10.65 52 143835 1206 42476242
Myelosuppression 80.16 10.65 19 143868 40442 42437006
Blood potassium decreased 78.02 10.65 196 143691 20188 42457260
Anosmia 71.76 10.65 88 143799 5088 42472360
Treatment failure 71.01 10.65 64 143823 62560 42414888
Pancreatitis 69.43 10.65 310 143577 42958 42434490
Arteriosclerosis coronary artery 67.76 10.65 176 143711 18501 42458947
Cytomegalovirus infection 66.35 10.65 14 143873 32292 42445156
Toxicity to various agents 66.24 10.65 477 143410 228659 42248789
Thrombocytopenia 65.78 10.65 375 143512 189904 42287544
Neuritis 63.46 10.65 91 143796 6129 42471319
Transient ischaemic attack 60.50 10.65 250 143637 33489 42443959
Pulmonary vasculitis 60.05 10.65 89 143798 6177 42471271
Cytokine release syndrome 58.74 10.65 39 143848 44488 42432960
Drug intolerance 58.67 10.65 114 143773 80310 42397138
Blood mercury abnormal 54.41 10.65 24 143863 258 42477190
Total lung capacity abnormal 54.39 10.65 71 143816 4372 42473076
Product use issue 52.41 10.65 113 143774 76638 42400810
Foetal exposure during pregnancy 51.69 10.65 50 143837 47261 42430187
IgM nephropathy 51.01 10.65 19 143868 126 42477322
Disease progression 50.22 10.65 282 143605 143374 42334074
Hepatic function abnormal 49.16 10.65 61 143826 51506 42425942
Carotid artery stenosis 48.95 10.65 75 143812 5361 42472087
Hypertensive crisis 48.72 10.65 107 143780 10099 42467349
Bundle branch block left 48.27 10.65 82 143805 6394 42471054
Sprue-like enteropathy 48.18 10.65 29 143858 618 42476830
Cardiac failure congestive 47.20 10.65 469 143418 85133 42392315
Pain of skin 47.14 10.65 92 143795 7988 42469460
Hypomagnesaemia 45.62 10.65 204 143683 28284 42449164
Hypovolaemia 45.60 10.65 112 143775 11373 42466075
Metabolic alkalosis 45.24 10.65 45 143842 2056 42475392
Drug resistance 45.17 10.65 30 143857 34218 42443230
Eye pruritus 45.00 10.65 111 143776 11301 42466147
Leukopenia 44.71 10.65 118 143769 74628 42402820
Eosinophilic granulomatosis with polyangiitis 42.88 10.65 92 143795 8546 42468902
Hospitalisation 42.47 10.65 120 143767 74210 42403238
Orthostatic intolerance 42.25 10.65 30 143857 853 42476595
Forced expiratory volume decreased 42.25 10.65 85 143802 7545 42469903
Amnesia 42.10 10.65 199 143688 28238 42449210
Muscle twitching 41.70 10.65 110 143777 11670 42465778
Lip swelling 41.36 10.65 150 143737 18903 42458545
Cardiomegaly 40.73 10.65 137 143750 16629 42460819
Pancytopenia 40.67 10.65 232 143655 117511 42359937
Chest pain 40.48 10.65 679 143208 138851 42338597
Pericardial disease 40.44 10.65 24 143863 498 42476950
Blood creatinine increased 39.88 10.65 556 143331 109447 42368001
Pulmonary valve disease 39.69 10.65 22 143865 399 42477049
Interstitial lung disease 39.63 10.65 134 143753 78328 42399120
Mycotic allergy 39.23 10.65 64 143823 4827 42472621
Choroidal effusion 39.09 10.65 19 143868 259 42477189
Acute myocardial infarction 38.79 10.65 332 143555 57833 42419615
Neutrophil count decreased 38.78 10.65 99 143788 63316 42414132
Completed suicide 38.44 10.65 496 143391 95969 42381479
Lower respiratory tract infection 37.98 10.65 50 143837 41156 42436292
Dust allergy 37.76 10.65 66 143821 5266 42472182
Mite allergy 37.75 10.65 64 143823 4982 42472466
Arteriosclerosis 37.68 10.65 140 143747 17849 42459599
Interstitial granulomatous dermatitis 37.19 10.65 17 143870 200 42477248
Neurological symptom 37.12 10.65 95 143792 9896 42467552
Shock 36.89 10.65 195 143692 28926 42448522
Sedation 35.93 10.65 30 143857 30445 42447003
Bacteraemia 35.72 10.65 20 143867 25020 42452428
Spirometry abnormal 35.54 10.65 63 143824 5083 42472365
Renal failure 35.53 10.65 682 143205 143044 42334404
Diplopia 35.21 10.65 149 143738 20167 42457281
Bronchopulmonary aspergillosis 34.96 10.65 11 143876 19418 42458030
Inappropriate antidiuretic hormone secretion 34.87 10.65 129 143758 16412 42461036
Therapy partial responder 34.86 10.65 12 143875 20009 42457439
Antineutrophil cytoplasmic antibody positive 34.85 10.65 57 143830 4308 42473140
Renal artery stenosis 34.75 10.65 41 143846 2276 42475172
Blood urea increased 34.55 10.65 209 143678 32584 42444864
Aspergillus infection 34.35 10.65 6 143881 15831 42461617
Blood chloride decreased 34.34 10.65 55 143832 4084 42473364
Hypochloraemia 34.16 10.65 27 143860 906 42476542
Low density lipoprotein decreased 33.91 10.65 31 143856 1273 42476175
Liver disorder 33.66 10.65 51 143836 39593 42437855
Septic shock 33.64 10.65 177 143710 91495 42385953
Glycosylated haemoglobin increased 33.53 10.65 108 143779 12816 42464632
Infection 33.44 10.65 231 143656 111837 42365611
Drug ineffective for unapproved indication 33.17 10.65 66 143821 46097 42431351
Pneumonia aspiration 33.13 10.65 75 143812 50003 42427445
Hyperkalaemia 32.60 10.65 415 143472 80043 42397405
Incorrect route of product administration 32.45 10.65 21 143866 24284 42453164
5-hydroxyindolacetic acid in urine increased 32.33 10.65 15 143872 183 42477265
Choroidal detachment 32.15 10.65 21 143866 519 42476929
Visual impairment 31.92 10.65 252 143635 42861 42434587
Rash papular 31.83 10.65 100 143787 11711 42465737
Conjunctivitis allergic 31.72 10.65 65 143822 5846 42471602
Blood sodium decreased 31.32 10.65 133 143754 18029 42459419
Malignant neoplasm progression 31.10 10.65 226 143661 108174 42369274
Fall 31.09 10.65 1023 142864 233497 42243951
Multiple organ dysfunction syndrome 30.97 10.65 196 143691 96839 42380609
Hypercalcaemia 30.96 10.65 132 143755 17926 42459522
Blindness 30.50 10.65 131 143756 17847 42459601
Physical examination abnormal 30.10 10.65 19 143868 442 42477006
Inappropriate schedule of product administration 29.95 10.65 195 143692 95707 42381741
Electrocardiogram Q wave abnormal 29.93 10.65 20 143867 514 42476934
Muscular weakness 29.83 10.65 421 143466 83077 42394371
Angina pectoris 29.33 10.65 201 143686 32695 42444753
Granulomatous pneumonitis 28.93 10.65 9 143878 31 42477417
Injury 28.66 10.65 150 143737 22166 42455282
Ventricular tachycardia 28.52 10.65 187 143700 29973 42447475
Intentional self-injury 28.46 10.65 8 143879 15194 42462254
Pneumocystis jirovecii pneumonia 28.22 10.65 26 143861 25155 42452293
Mucosal inflammation 27.98 10.65 80 143807 49294 42428154
Intestinal villi atrophy 27.78 10.65 13 143874 162 42477286
Bone marrow failure 27.68 10.65 43 143844 33050 42444398
Platelet count decreased 27.54 10.65 317 143570 138264 42339184
Cytomegalovirus infection reactivation 27.14 10.65 3 143884 11175 42466273
Tinnitus 27.11 10.65 179 143708 28759 42448689
Erectile dysfunction 27.02 10.65 160 143727 24753 42452695
Hepatic neoplasm 26.80 10.65 35 143852 2156 42475292
Occult blood 26.74 10.65 24 143863 962 42476486
Normochromic normocytic anaemia 26.71 10.65 79 143808 8952 42468496
Angina unstable 26.45 10.65 92 143795 11356 42466092
Mitral valve incompetence 26.34 10.65 118 143769 16371 42461077
Respiratory symptom 26.31 10.65 90 143797 11016 42466432
Blood pressure systolic increased 26.20 10.65 173 143714 27795 42449653
Aplastic anaemia 26.19 10.65 5 143882 12379 42465069
Aortic valve incompetence 26.15 10.65 64 143823 6484 42470964
Subarachnoid haemorrhage 25.75 10.65 107 143780 14365 42463083
Graft versus host disease 25.73 10.65 6 143881 12919 42464529
Nodular rash 25.63 10.65 11 143876 110 42477338
Diabetic hyperosmolar coma 25.47 10.65 18 143869 508 42476940
Lymphocyte count decreased 25.36 10.65 34 143853 27775 42449673
Miosis 25.31 10.65 7 143880 13439 42464009
Colitis 25.28 10.65 77 143810 46495 42430953
Atrial fibrillation 25.13 10.65 633 143254 138960 42338488
Drug dependence 25.11 10.65 37 143850 29057 42448391
Alkalosis hypochloraemic 24.91 10.65 15 143872 320 42477128
Akathisia 24.89 10.65 3 143884 10448 42467000
Polydipsia 24.85 10.65 50 143837 4438 42473010
Oedema peripheral 24.77 10.65 618 143269 135458 42341990
Heart rate increased 24.76 10.65 282 143605 52973 42424475
Neurotoxicity 24.68 10.65 26 143861 23625 42453823
Sopor 24.62 10.65 7 143880 13195 42464253
Actinic keratosis 24.41 10.65 54 143833 5122 42472326
Bradycardia 24.40 10.65 415 143472 85069 42392379
Pericarditis 24.39 10.65 100 143787 13344 42464104
Epiploic appendagitis 24.38 10.65 9 143878 58 42477390
Haematotoxicity 24.18 10.65 4 143883 10981 42466467
Renal tubular necrosis 24.00 10.65 124 143763 18230 42459218
Disseminated intravascular coagulation 23.97 10.65 29 143858 24765 42452683
Transplant rejection 23.91 10.65 8 143879 13580 42463868
Type 2 diabetes mellitus 23.61 10.65 124 143763 18347 42459101
Polyuria 23.61 10.65 81 143806 9930 42467518
Hepatojugular reflux 23.48 10.65 19 143868 660 42476788
Appendicitis 23.44 10.65 21 143866 20592 42456856
Extrasystoles 23.44 10.65 47 143840 4162 42473286
Orthostatic hypotension 23.35 10.65 180 143707 30390 42447058
Capillaritis 23.32 10.65 33 143854 2195 42475253
Mitral valve disease 23.11 10.65 27 143860 1483 42475965
Seizure 23.09 10.65 278 143609 120283 42357165
Hypertensive emergency 22.93 10.65 25 143862 1272 42476176
Pulmonary alveolar haemorrhage 22.89 10.65 105 143782 14711 42462737
Tricuspid valve incompetence 22.87 10.65 86 143801 11027 42466421
Arrhythmia 22.74 10.65 222 143665 40095 42437353
Haemophagocytic lymphohistiocytosis 22.66 10.65 17 143870 18205 42459243
Supraventricular extrasystoles 22.63 10.65 45 143842 3961 42473487
Expired product administered 22.60 10.65 46 143841 4117 42473331
Dry skin 22.49 10.65 256 143631 48082 42429366
Peritonitis 22.39 10.65 18 143869 18615 42458833
Cytopenia 22.18 10.65 16 143871 17481 42459967
Stomatitis 22.11 10.65 91 143796 50238 42427210
Electrolyte imbalance 21.99 10.65 115 143772 16986 42460462
Blood triglycerides increased 21.91 10.65 109 143778 15787 42461661
Congenital diaphragmatic anomaly 21.69 10.65 7 143880 28 42477420
Immune reconstitution inflammatory syndrome 21.66 10.65 4 143883 10139 42467309
Echocardiogram abnormal 21.63 10.65 24 143863 1246 42476202
Coronary arterial stent insertion 21.60 10.65 44 143843 3941 42473507
Neoplasm 21.43 10.65 58 143829 6247 42471201
Pseudolymphoma 21.25 10.65 18 143869 667 42476781
Bronchiectasis 20.92 10.65 18 143869 18001 42459447
Mastitis 20.80 10.65 11 143876 181 42477267
Hypophagia 20.74 10.65 159 143728 26797 42450651
Therapy non-responder 20.72 10.65 101 143786 53258 42424190
Pleural effusion 20.59 10.65 219 143668 96947 42380501
Fatigue 20.56 10.65 1722 142165 433919 42043529
C-reactive protein increased 20.47 10.65 128 143759 63432 42414016
Ascites 20.47 10.65 110 143777 56568 42420880
Pulmonary valve stenosis congenital 20.47 10.65 10 143877 138 42477310
Anxiety 20.27 10.65 534 143353 118026 42359422
Drug hypersensitivity 20.26 10.65 226 143661 99163 42378285
Cardiac discomfort 20.11 10.65 18 143869 719 42476729
Epilepsy 20.04 10.65 36 143851 26135 42451313
Device leakage 20.04 10.65 5 143882 10280 42467168
Acquired acrodermatitis enteropathica 20.02 10.65 5 143882 5 42477443
Hypertension 20.02 10.65 721 143166 166483 42310965
Lichen planus 19.82 10.65 23 143864 1254 42476194
Gastrointestinal tract mucosal pigmentation 19.59 10.65 16 143871 563 42476885
5-hydroxyindolacetic acid increased 19.53 10.65 9 143878 108 42477340
Tumour lysis syndrome 19.45 10.65 28 143859 22203 42455245
No adverse event 19.45 10.65 67 143820 38954 42438494
Microalbuminuria 19.34 10.65 19 143868 855 42476593
Hypogammaglobulinaemia 19.24 10.65 8 143879 11883 42465565
Blood pressure decreased 19.20 10.65 290 143597 58042 42419406
Gouty arthritis 18.88 10.65 22 143865 1205 42476243
Transaminases increased 18.84 10.65 53 143834 32832 42444616
Pharyngeal oedema 18.83 10.65 54 143833 6014 42471434
Synovitis 18.75 10.65 15 143872 15552 42461896
Precancerous skin lesion 18.64 10.65 16 143871 604 42476844
Dystonia 18.56 10.65 10 143877 12780 42464668
Psoriasis 18.55 10.65 248 143639 48356 42429092
Lymphomatoid papulosis 18.42 10.65 11 143876 231 42477217
Left ventricular hypertrophy 18.26 10.65 71 143816 9248 42468200
Enterococcal infection 18.08 10.65 9 143878 12030 42465418
Renal artery angioplasty 18.01 10.65 5 143882 10 42477438
Hyperhidrosis 17.95 10.65 416 143471 90096 42387352
Vestibular neuronitis 17.94 10.65 12 143875 309 42477139
Febrile bone marrow aplasia 17.90 10.65 6 143881 10175 42467273
Atrioventricular block second degree 17.88 10.65 42 143845 4145 42473303
Rhabdomyolysis 17.84 10.65 366 143521 77653 42399795
Coronary artery occlusion 17.79 10.65 79 143808 10918 42466530
Agranulocytosis 17.79 10.65 49 143838 30563 42446885
Toxic epidermal necrolysis 17.74 10.65 40 143847 26710 42450738
White blood cell count decreased 17.71 10.65 264 143623 110132 42367316
Osteoarthritis 17.70 10.65 142 143745 24263 42453185
High density lipoprotein decreased 17.64 10.65 40 143847 3857 42473591
Bacterial infection 17.44 10.65 43 143844 27836 42449612
Product monitoring error 17.42 10.65 43 143844 4380 42473068
Gastrointestinal angiodysplasia 17.40 10.65 16 143871 662 42476786
Kidney transplant rejection 17.35 10.65 4 143883 8679 42468769
Somnolence 17.32 10.65 354 143533 140751 42336697
Hemiparesis 17.20 10.65 109 143778 17267 42460181
Squamous cell carcinoma 17.18 10.65 88 143799 12894 42464554
Renin increased 17.18 10.65 10 143877 200 42477248
Carcinoid tumour of the gastrointestinal tract 17.15 10.65 7 143880 61 42477387
Laryngeal cleft 17.11 10.65 5 143882 13 42477435
Renal artery stent placement 17.11 10.65 5 143882 13 42477435
Helicobacter gastritis 17.10 10.65 22 143865 1335 42476113
Supraventricular tachycardia 17.04 10.65 85 143802 12323 42465125
Drug interaction 16.93 10.65 1081 142806 265918 42211530
Diastolic dysfunction 16.90 10.65 57 143830 6926 42470522
Palpitations 16.90 10.65 253 143634 50544 42426904
Thrombotic microangiopathy 16.88 10.65 15 143872 14767 42462681
Infusion related reaction 16.84 10.65 128 143759 60678 42416770
Fibrous histiocytoma 16.82 10.65 12 143875 344 42477104
Ventricular arrhythmia 16.77 10.65 53 143834 6226 42471222
Premature baby 16.72 10.65 33 143854 23120 42454328
Condition aggravated 16.69 10.65 715 143172 260039 42217409
Contraindicated product administered 16.59 10.65 38 143849 25234 42452214
Blood follicle stimulating hormone increased 16.58 10.65 10 143877 214 42477234
Renin decreased 16.55 10.65 4 143883 3 42477445
Muscle necrosis 16.52 10.65 19 143868 1026 42476422
Blood phosphorus increased 16.48 10.65 11 143876 12514 42464934
End stage renal disease 16.40 10.65 19 143868 16539 42460909
Aggression 16.34 10.65 85 143802 44078 42433370
Hyperphosphataemia 16.34 10.65 12 143875 12992 42464456
Neutrophil count increased 16.31 10.65 26 143861 19778 42457670
Memory impairment 16.27 10.65 249 143638 49973 42427475
Substance abuse 16.10 10.65 5 143882 8900 42468548
Patent ductus arteriosus 16.09 10.65 36 143851 3440 42474008
Renal injury 16.08 10.65 83 143804 12197 42465251
Phonophobia 15.99 10.65 11 143876 297 42477151
Angiopathy 15.87 10.65 47 143840 5330 42472118
Paresis cranial nerve 15.73 10.65 7 143880 77 42477371
Hemiataxia 15.71 10.65 6 143881 43 42477405
Neoplasm progression 15.70 10.65 48 143839 28952 42448496
Shoshin beriberi 15.65 10.65 7 143880 78 42477370
Acute cutaneous lupus erythematosus 15.57 10.65 7 143880 79 42477369
Enterocolitis 15.56 10.65 7 143880 9922 42467526
Product complaint 15.55 10.65 50 143837 5927 42471521
Carotid arteriosclerosis 15.40 10.65 28 143859 2304 42475144
Asthenia 15.36 10.65 1123 142764 279670 42197778
Myalgia 15.35 10.65 429 143458 95651 42381797
Shock hypoglycaemic 15.26 10.65 7 143880 83 42477365
Feeling abnormal 15.18 10.65 325 143562 69461 42407987
Coronary artery bypass 15.12 10.65 43 143844 4767 42472681
Ventricular hypertrophy 15.08 10.65 43 143844 4773 42472675
Neutropenic sepsis 15.05 10.65 19 143868 15927 42461521
Electrocardiogram U-wave abnormality 15.04 10.65 6 143881 49 42477399
Hyperammonaemia 14.99 10.65 4 143883 7862 42469586
Pneumothorax 14.98 10.65 36 143851 23507 42453941
Neuralgia 14.94 10.65 41 143846 25606 42451842
Electrocardiogram U wave present 14.94 10.65 5 143882 23 42477425
Myocardial ischaemia 14.93 10.65 107 143780 17655 42459793
Blood pressure diastolic decreased 14.91 10.65 72 143815 10303 42467145
Atrioventricular block first degree 14.85 10.65 52 143835 6439 42471009
Infective pulmonary exacerbation of cystic fibrosis 14.85 10.65 4 143883 7814 42469634
Basal cell carcinoma 14.75 10.65 129 143758 22604 42454844
Coma 14.70 10.65 113 143774 53441 42424007
Fluid intake reduced 14.63 10.65 38 143849 3994 42473454
Tendon rupture 14.57 10.65 60 143827 8023 42469425
Prothrombin time prolonged 14.55 10.65 67 143820 9402 42468046
Drug-induced liver injury 14.54 10.65 73 143814 38200 42439248
Preternatural anus 14.24 10.65 7 143880 98 42477350
Weight loss poor 14.23 10.65 9 143878 210 42477238
Acute myeloid leukaemia 14.18 10.65 34 143853 22222 42455226
Hypoglycaemia 14.08 10.65 282 143605 59572 42417876
CD4/CD8 ratio increased 14.08 10.65 3 143884 0 42477448
Waist circumference increased 14.08 10.65 17 143870 967 42476481
Mydriasis 14.03 10.65 6 143881 8764 42468684
Sleep disorder due to a general medical condition 14.02 10.65 104 143783 17349 42460099
Anhedonia 14.00 10.65 57 143830 7583 42469865
Sinus bradycardia 13.99 10.65 92 143795 14761 42462687
Systemic infection 13.96 10.65 44 143843 5161 42472287
Left ventricular dysfunction 13.88 10.65 76 143811 11425 42466023
Pancreatitis necrotising 13.87 10.65 35 143852 3614 42473834
Choroidal haemorrhage 13.87 10.65 7 143880 104 42477344
Therapeutic response decreased 13.83 10.65 71 143816 36941 42440507
Accelerated hypertension 13.82 10.65 10 143877 293 42477155
Drug use disorder 13.69 10.65 9 143878 10324 42467124
Haematocrit decreased 13.68 10.65 179 143708 34729 42442719
Intestinal angioedema 13.65 10.65 9 143878 226 42477222
Hormone level abnormal 13.65 10.65 12 143875 468 42476980
Intercapillary glomerulosclerosis 13.56 10.65 6 143881 65 42477383
Aortic arteriosclerosis 13.48 10.65 43 143844 5077 42472371
Eosinophilic colitis 13.45 10.65 10 143877 306 42477142
Multiple-drug resistance 13.44 10.65 4 143883 7318 42470130
Photosensitivity reaction 13.40 10.65 81 143806 12621 42464827
Dyspnoea at rest 13.37 10.65 38 143849 4211 42473237
Disturbance in attention 13.36 10.65 157 143730 29709 42447739
Renal artery restenosis 13.27 10.65 4 143883 12 42477436
Hypopnoea 13.25 10.65 5 143882 7877 42469571
Low density lipoprotein increased 13.22 10.65 44 143843 5311 42472137
Hypothyroidism 13.20 10.65 166 143721 31918 42445530
Agitation 13.20 10.65 146 143741 64168 42413280
Forced expiratory flow decreased 13.15 10.65 8 143879 174 42477274
Neuropathy peripheral 12.95 10.65 254 143633 101599 42375849
Bundle branch block right 12.94 10.65 58 143829 8048 42469400
Weaning failure 12.92 10.65 9 143878 248 42477200
Device related infection 12.91 10.65 31 143856 20248 42457200
Vascular purpura 12.88 10.65 25 143862 2161 42475287
Rales 12.87 10.65 74 143813 11326 42466122
Anaemia 12.86 10.65 795 143092 279483 42197965
Dermatitis acneiform 12.86 10.65 5 143882 7734 42469714
Lymphangiectasia intestinal 12.81 10.65 4 143883 14 42477434
Altered state of consciousness 12.79 10.65 53 143834 29206 42448242
Hallucination, auditory 12.73 10.65 19 143868 14845 42462603
Post procedural haematoma 12.68 10.65 21 143866 1604 42475844
Frequent bowel movements 12.64 10.65 34 143853 21373 42456075
Pathogen resistance 12.62 10.65 12 143875 11438 42466010
Vertigo 12.59 10.65 174 143713 34173 42443275
Gastrointestinal mucosal necrosis 12.56 10.65 8 143879 189 42477259
Carcinogenicity 12.53 10.65 6 143881 79 42477369
Electrocardiogram QT interval 12.52 10.65 5 143882 41 42477407
Dermatomyositis 12.51 10.65 21 143866 1622 42475826
Balance disorder 12.41 10.65 228 143659 47417 42430031
Posterior reversible encephalopathy syndrome 12.39 10.65 15 143872 12806 42464642
Dilatation ventricular 12.36 10.65 27 143860 2539 42474909
Stent placement 12.32 10.65 43 143844 5317 42472131
Myosclerosis 12.29 10.65 9 143878 269 42477179
Pruritus 12.26 10.65 766 143121 188005 42289443
Hypertensive heart disease 12.26 10.65 27 143860 2553 42474895
Body temperature decreased 12.22 10.65 87 143800 14326 42463122
Myopathy 12.22 10.65 84 143803 13677 42463771
Acute respiratory failure 12.13 10.65 79 143808 38779 42438669
Myelodysplastic syndrome 12.06 10.65 38 143849 22707 42454741
Spinal cord infarction 12.06 10.65 13 143874 653 42476795
Suture insertion 12.02 10.65 5 143882 46 42477402
Hyperchloruria 12.01 10.65 3 143884 3 42477445
Hypermagnesuria 12.01 10.65 3 143884 3 42477445
Hypoaesthesia 11.95 10.65 321 143566 71142 42406306
Hallucination, visual 11.95 10.65 34 143853 20986 42456462
Exposure during pregnancy 11.94 10.65 7 143880 8541 42468907
Hypercalciuria 11.91 10.65 10 143877 366 42477082
Respiratory depression 11.88 10.65 29 143858 18839 42458609
Constipation 11.88 10.65 438 143449 161853 42315595
Incontinence 11.76 10.65 50 143837 6780 42470668
Osteitis deformans 11.74 10.65 5 143882 49 42477399
Hepatitis B 11.72 10.65 4 143883 6707 42470741
Schizophrenia 11.69 10.65 11 143876 10539 42466909
Alanine aminotransferase increased 11.69 10.65 219 143668 88187 42389261
Peripheral vascular disorder 11.66 10.65 42 143845 5275 42472173
Electrocardiogram QT prolonged 11.65 10.65 227 143660 47718 42429730
Liver function test increased 11.63 10.65 32 143855 19966 42457482
Chronic kidney disease 11.59 10.65 224 143663 47017 42430431
Pyelitis 11.55 10.65 7 143880 151 42477297
Cerebellar infarction 11.54 10.65 24 143863 2181 42475267
Non-cardiogenic pulmonary oedema 11.54 10.65 15 143872 920 42476528
Diffuse large B-cell lymphoma 11.53 10.65 9 143878 9445 42468003
Parotitis 11.50 10.65 18 143869 1310 42476138
Catarrh 11.49 10.65 3 143884 5983 42471465
Drug reaction with eosinophilia and systemic symptoms 11.45 10.65 89 143798 41986 42435462
Craniofacial fracture 11.44 10.65 10 143877 387 42477061
Aortic valve stenosis 11.44 10.65 29 143858 3003 42474445
Dermatosis 11.42 10.65 10 143877 388 42477060
Heart valve incompetence 11.41 10.65 20 143867 1599 42475849
Pulmonary fibrosis 11.39 10.65 139 143748 26542 42450906
Asphyxia 11.38 10.65 7 143880 8319 42469129
Accidental overdose 11.36 10.65 53 143834 28277 42449171
Gastroduodenal ulcer 11.30 10.65 13 143874 702 42476746
Renal function test abnormal 11.28 10.65 29 143858 3028 42474420
Skin toxicity 11.27 10.65 4 143883 6545 42470903
Rhinovirus infection 11.27 10.65 4 143883 6544 42470904
Delirium 11.27 10.65 118 143769 52401 42425047
Atrioventricular block 11.24 10.65 63 143824 9552 42467896
SARS-CoV-2 test positive 11.21 10.65 7 143880 8253 42469195
Torsade de pointes 11.19 10.65 58 143829 8536 42468912
Abdominal discomfort 11.18 10.65 333 143554 74922 42402526
Stenosis 11.15 10.65 23 143864 2078 42475370
Nail discolouration 11.15 10.65 17 143870 1210 42476238
Intentional product use issue 11.09 10.65 173 143714 71660 42405788
Gait disturbance 11.09 10.65 420 143467 97580 42379868
Victim of chemical submission 11.08 10.65 7 143880 163 42477285
Gout 11.05 10.65 144 143743 27911 42449537
Behaviour disorder 11.01 10.65 5 143882 7049 42470399
Fear 10.99 10.65 69 143818 10896 42466552
Blood testosterone decreased 10.98 10.65 39 143848 4863 42472585
Therapeutic response shortened 10.97 10.65 18 143869 13536 42463912
Dieulafoy's vascular malformation 10.94 10.65 4 143883 25 42477423
Abnormal behaviour 10.90 10.65 49 143838 26402 42451046
Oesophageal carcinoma 10.88 10.65 10 143877 9686 42467762
Nodule 10.83 10.65 76 143811 12458 42464990
Alkalosis hypokalaemic 10.81 10.65 3 143884 6 42477442
Basilar artery thrombosis 10.81 10.65 8 143879 243 42477205
Myasthenia gravis 10.81 10.65 24 143863 16113 42461335
Pemphigoid 10.78 10.65 71 143816 11396 42466052
Hypertension neonatal 10.77 10.65 6 143881 110 42477338
Cutaneous T-cell lymphoma 10.76 10.65 22 143865 1976 42475472
Device pacing issue 10.71 10.65 5 143882 62 42477386
Vision blurred 10.70 10.65 247 143640 53452 42423996
Blood growth hormone increased 10.67 10.65 12 143875 632 42476816
Migraine 10.67 10.65 132 143755 25282 42452166

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 2066.83 9.76 2923 336528 214730 110035118
Hypokalaemia 895.74 9.76 1827 337624 180621 110069227
Acute kidney injury 863.22 9.76 4046 335405 631384 109618464
Pemphigus 569.33 9.76 20 339431 214550 110035298
Angioedema 555.42 9.76 1046 338405 97454 110152394
Hand deformity 554.38 9.76 28 339423 218478 110031370
Maternal exposure during pregnancy 541.73 9.76 71 339380 254812 109995036
Anti-cyclic citrullinated peptide antibody positive 525.84 9.76 6 339445 181978 110067870
Duodenal ulcer perforation 499.93 9.76 9 339442 177691 110072157
Off label use 496.82 9.76 2649 336802 1497536 108752312
Systemic lupus erythematosus 488.39 9.76 94 339357 254244 109995604
Cerebrovascular accident 439.08 9.76 1389 338062 179895 110069953
Blood pressure increased 434.25 9.76 1756 337695 256617 109993231
Glossodynia 432.75 9.76 79 339372 221925 110027923
Myocardial infarction 426.72 9.76 1429 338022 190654 110059194
Folliculitis 414.35 9.76 25 339426 167628 110082220
Synovitis 396.93 9.76 172 339279 273920 109975928
Muscle injury 357.24 9.76 18 339433 140789 110109059
Helicobacter infection 349.57 9.76 67 339384 181810 110068038
Syncope 349.38 9.76 1388 338063 201148 110048700
Lower respiratory tract infection 348.13 9.76 155 339296 242951 110006897
Dehydration 342.38 9.76 1730 337721 277781 109972067
Irritable bowel syndrome 331.98 9.76 53 339398 164162 110085686
Lactic acidosis 296.95 9.76 786 338665 92025 110157823
Hypotension 295.17 9.76 2673 336778 521176 109728672
Treatment failure 276.14 9.76 266 339185 276968 109972880
Sleep disorder due to general medical condition, insomnia type 272.85 9.76 12 339439 105631 110144217
Blood potassium decreased 267.69 9.76 544 338907 53570 110196278
Facet joint syndrome 264.10 9.76 7 339444 96821 110153027
Exposure during pregnancy 263.90 9.76 92 339359 167332 110082516
Wound 260.10 9.76 203 339248 234234 110015614
Coronary artery disease 257.20 9.76 634 338817 71056 110178792
Blood glucose increased 257.19 9.76 943 338508 131553 110118295
Drug intolerance 257.08 9.76 539 338912 405973 109843875
Drug abuse 251.00 9.76 115 339336 177296 110072552
Stomatitis 241.54 9.76 284 339167 269958 109979890
Cardiospasm 238.50 9.76 163 339288 4804 110245044
C-reactive protein abnormal 236.39 9.76 54 339397 129641 110120207
Product use in unapproved indication 236.33 9.76 652 338799 446725 109803123
Pericarditis 234.00 9.76 197 339254 218917 110030931
Fall 232.21 9.76 2851 336600 600631 109649217
Impaired healing 227.65 9.76 163 339288 196554 110053294
Palmoplantar keratoderma 224.27 9.76 162 339289 5225 110244623
Rheumatoid factor positive 218.65 9.76 66 339385 131574 110118274
Liver injury 218.28 9.76 94 339357 150319 110099529
Lip dry 217.11 9.76 26 339425 100057 110149791
Fibromyalgia 213.47 9.76 130 339321 170779 110079069
Psoriatic arthropathy 212.45 9.76 175 339276 196586 110053262
Blister 211.83 9.76 231 339220 227145 110022703
Dizziness 210.17 9.76 3156 336295 695037 109554811
Atrial tachycardia 208.54 9.76 194 339257 8984 110240864
Pruritus genital 205.19 9.76 166 339285 6356 110243492
Transient ischaemic attack 204.78 9.76 542 338909 63440 110186408
Contraindicated product administered 201.05 9.76 281 339170 247986 110001862
Carotid artery occlusion 199.83 9.76 193 339258 9372 110240476
Sleep terror 194.88 9.76 162 339289 6448 110243400
Arthropathy 193.91 9.76 367 339084 287155 109962693
Live birth 193.44 9.76 4 339447 69480 110180368
Drug ineffective 193.19 9.76 3398 336053 1517142 108732706
Drug interaction 192.69 9.76 2364 337087 497819 109752029
Joint range of motion decreased 191.90 9.76 67 339384 121765 110128083
Infection 190.37 9.76 529 338922 361671 109888177
Febrile neutropenia 190.28 9.76 432 339019 316335 109933513
Palpitations 186.78 9.76 974 338477 158238 110091610
Tension headache 185.91 9.76 186 339265 9432 110240416
Angina pectoris 176.80 9.76 505 338946 61790 110188058
Arterial occlusive disease 174.43 9.76 225 339226 15083 110234765
Facial pain 169.40 9.76 222 339229 15117 110234731
Ill-defined disorder 167.47 9.76 141 339310 156712 110093136
Peripheral venous disease 165.87 9.76 29 339422 84088 110165760
Anosmia 165.69 9.76 198 339253 12274 110237574
Swelling 164.19 9.76 541 338910 350500 109899348
Discomfort 164.06 9.76 253 339198 214454 110035394
Immunisation 163.70 9.76 109 339342 3074 110246774
Inappropriate antidiuretic hormone secretion 163.50 9.76 337 339114 33514 110216334
Cardiac failure congestive 161.02 9.76 900 338551 150100 110099748
Infusion related reaction 157.98 9.76 618 338833 380544 109869304
Sprue-like enteropathy 157.61 9.76 85 339366 1611 110248237
Pancreatitis acute 157.07 9.76 474 338977 59800 110190048
Wound infection 155.48 9.76 51 339400 96414 110153434
Mobility decreased 153.19 9.76 311 339140 237111 110012737
Bursitis 144.67 9.76 112 339339 129806 110120042
Milk-alkali syndrome 144.33 9.76 85 339366 1920 110247928
Blepharospasm 142.40 9.76 6 339445 54845 110195003
Autoimmune disorder 142.06 9.76 17 339434 65466 110184382
Neutropenia 141.22 9.76 630 338821 373990 109875858
Grip strength decreased 140.96 9.76 36 339415 80138 110169710
Myelosuppression 136.79 9.76 59 339392 94281 110155567
Gangrene 135.21 9.76 206 339245 16135 110233713
Hepatic enzyme increased 133.12 9.76 520 338931 320372 109929476
Joint swelling 132.50 9.76 806 338645 442039 109807809
Therapy non-responder 131.40 9.76 174 339277 157133 110092715
Neurologic neglect syndrome 130.79 9.76 152 339299 9146 110240702
Vasculitis 130.50 9.76 319 339132 35554 110214294
Type 2 diabetes mellitus 128.65 9.76 216 339235 177016 110072832
Carotid artery thrombosis 128.02 9.76 153 339298 9485 110240363
Blood pressure inadequately controlled 126.63 9.76 136 339315 7497 110242351
Epilepsy 125.42 9.76 76 339375 100133 110149715
Lower limb fracture 124.70 9.76 38 339413 75310 110174538
Renal failure 123.65 9.76 1149 338302 225425 110024423
Pneumonia 123.39 9.76 1921 337530 874793 109375055
Hypovolaemia 123.12 9.76 231 339220 21443 110228405
Condition aggravated 122.57 9.76 1556 337895 733280 109516568
Hypercalcaemia 121.65 9.76 367 339084 46290 110203558
Therapeutic product effect decreased 121.59 9.76 366 339085 243950 110005898
Night sweats 121.59 9.76 139 339312 133844 110116004
Onychomadesis 118.52 9.76 5 339446 45658 110204190
Hypertensive crisis 116.96 9.76 242 339209 24130 110225718
Pain of skin 116.94 9.76 216 339235 19813 110230035
Alopecia 114.32 9.76 654 338797 364099 109885749
Hyperkalaemia 112.30 9.76 758 338693 135038 110114810
Pregnancy 111.41 9.76 13 339438 51054 110198794
Prescribed overdose 110.20 9.76 66 339385 87515 110162333
Adjustment disorder 108.16 9.76 149 339302 10646 110239202
Hypersensitivity 106.35 9.76 764 338687 403234 109846614
Cataract 105.73 9.76 504 338947 78981 110170867
Product use issue 105.29 9.76 545 338906 311150 109938698
Adjustment disorder with depressed mood 104.13 9.76 8 339443 43875 110205973
Subarachnoid haemorrhage 103.68 9.76 260 339191 29442 110220406
Death 102.79 9.76 1518 337933 697351 109552497
Sinus congestion 101.52 9.76 262 339189 30197 110219651
Hypochloraemia 101.15 9.76 86 339365 3532 110246316
Hypoglycaemia 98.96 9.76 653 338798 115451 110134397
Coordination abnormal 98.94 9.76 231 339220 24997 110224851
Chronic sinusitis 98.73 9.76 230 339221 24854 110224994
Blood pressure systolic increased 98.17 9.76 509 338942 82482 110167366
Liver disorder 97.21 9.76 180 339271 142063 110107785
Personality disorder 96.71 9.76 155 339296 12682 110237166
X-ray abnormal 96.25 9.76 5 339446 38112 110211736
Skin haemorrhage 95.92 9.76 226 339225 24601 110225247
Blood sodium decreased 94.85 9.76 296 339155 38023 110211825
Intentional product use issue 94.51 9.76 415 339036 247491 110002357
Diplopia 94.07 9.76 313 339138 41581 110208267
C-reactive protein increased 93.66 9.76 348 339103 217571 110032277
Vaginal flatulence 93.37 9.76 148 339303 11996 110237852
Atrial fibrillation 93.32 9.76 1097 338354 228545 110021303
Macular degeneration 92.36 9.76 205 339246 21454 110228394
Hypomagnesaemia 91.62 9.76 398 339053 59972 110189876
Cytomegalovirus infection 90.93 9.76 27 339424 54417 110195431
Hemiparesis 90.69 9.76 319 339132 43584 110206264
Blindness 90.12 9.76 281 339170 36078 110213770
Obesity 90.02 9.76 130 339321 113221 110136627
Sleep disorder 88.82 9.76 312 339139 198332 110051516
Nausea 88.50 9.76 4636 334815 1231054 109018794
Skin exfoliation 87.87 9.76 514 338937 87137 110162711
Blood urea increased 87.80 9.76 368 339083 54589 110195259
Rhabdomyolysis 87.27 9.76 651 338800 119750 110130098
Hepatic function abnormal 86.16 9.76 88 339363 89207 110160641
Motor dysfunction 84.52 9.76 213 339238 24193 110225655
Loss of employment 84.43 9.76 75 339376 3269 110246579
Hemiplegia 84.37 9.76 204 339247 22578 110227270
Bradycardia 83.47 9.76 786 338665 154731 110095117
Bone erosion 83.11 9.76 20 339431 46351 110203497
Blood creatinine increased 82.60 9.76 892 338559 181997 110067851
Proctitis 82.31 9.76 169 339282 16758 110233090
Arteriosclerosis coronary artery 81.60 9.76 214 339237 24904 110224944
Sciatica 81.53 9.76 98 339353 92301 110157547
Neutrophil count decreased 80.92 9.76 155 339296 120786 110129062
Disease progression 80.54 9.76 430 339021 243604 110006244
Blood pressure diastolic decreased 80.48 9.76 268 339183 35617 110214231
Asthenia 79.62 9.76 2719 336732 686280 109563568
Arteriosclerosis 79.43 9.76 210 339241 24557 110225291
Angina unstable 78.66 9.76 163 339288 16269 110233579
Sensory loss 78.25 9.76 191 339260 21266 110228582
Cytokine release syndrome 77.77 9.76 61 339390 70245 110179603
Ventricular tachycardia 77.66 9.76 332 339119 49677 110200171
Inflammation 77.02 9.76 318 339133 192920 110056928
Radiculopathy 76.87 9.76 178 339273 19158 110230690
Lip swelling 76.86 9.76 334 339117 50333 110199515
Muscle twitching 75.72 9.76 233 339218 29702 110220146
Sinus disorder 75.70 9.76 247 339204 32481 110217367
Eating disorder 74.20 9.76 236 339215 30622 110219226
Lung diffusion test abnormal 73.95 9.76 32 339419 363 110249485
Eye pruritus 73.70 9.76 245 339206 32530 110217318
Female genital tract fistula 73.44 9.76 159 339292 16360 110233488
Chest pain 73.07 9.76 1589 337862 374786 109875062
Hypertensive emergency 72.62 9.76 69 339382 3282 110246566
Anxiety 72.23 9.76 1473 337978 343605 109906243
Dysarthria 72.21 9.76 474 338977 83647 110166201
Feeling abnormal 71.96 9.76 860 338591 179851 110069997
Breast cancer stage II 71.04 9.76 3 339448 27372 110222476
Drug resistance 70.19 9.76 43 339408 56331 110193517
Carotid artery stenosis 69.99 9.76 112 339339 9151 110240697
Acute myocardial infarction 69.46 9.76 468 338983 83309 110166539
Hypercholesterolaemia 69.39 9.76 107 339344 90730 110159118
Thrombocytopenia 69.29 9.76 710 338741 348175 109901673
Heart rate increased 68.92 9.76 710 338741 143124 110106724
Drug hypersensitivity 68.51 9.76 981 338470 453109 109796739
Hyperhidrosis 68.40 9.76 877 338574 186421 110063427
Rash papular 67.94 9.76 213 339238 27426 110222422
Liver function test increased 67.93 9.76 104 339347 88444 110161404
Blood lactic acid decreased 67.63 9.76 34 339417 554 110249294
Coeliac disease 67.56 9.76 24 339427 43163 110206685
Sneezing 67.45 9.76 234 339217 31750 110218098
Choroidal effusion 67.42 9.76 39 339412 851 110248997
Tinnitus 67.28 9.76 365 339086 60175 110189673
Dry mouth 67.27 9.76 350 339101 199598 110050250
Bundle branch block left 66.63 9.76 132 339319 12756 110237092
Pyrexia 66.58 9.76 2176 337275 896089 109353759
Sinus bradycardia 65.95 9.76 220 339231 29263 110220585
Blood cholesterol increased 65.86 9.76 317 339134 184468 110065380
Lung disorder 65.26 9.76 307 339144 179740 110070108
Neuritis 65.10 9.76 96 339355 7303 110242545
Sepsis 65.07 9.76 666 338785 326680 109923168
Pulmonary vasculitis 64.90 9.76 90 339361 6470 110243378
Affect lability 64.90 9.76 163 339288 18474 110231374
Vaginal discharge 64.87 9.76 159 339292 17749 110232099
Wheezing 64.55 9.76 488 338963 254742 109995106
Respiratory tract congestion 64.42 9.76 225 339226 30632 110219216
Abdominal discomfort 64.03 9.76 838 338613 393020 109856828
Paraesthesia oral 63.90 9.76 238 339213 33433 110216415
Musculoskeletal stiffness 63.89 9.76 550 338901 279272 109970576
Drug ineffective for unapproved indication 63.52 9.76 138 339313 102700 110147148
Atrioventricular block first degree 63.33 9.76 137 339314 14088 110235760
Blood chloride decreased 63.18 9.76 106 339345 9009 110240839
Abortion spontaneous 63.00 9.76 14 339437 34268 110215580
Disturbance in attention 62.43 9.76 364 339087 61631 110188217
Road traffic accident 62.38 9.76 149 339302 107249 110142599
Hip arthroplasty 62.27 9.76 48 339403 55765 110194083
Orthostatic intolerance 62.14 9.76 52 339399 2089 110247759
Dry skin 61.25 9.76 551 338900 107102 110142746
Cardiac output increased 60.66 9.76 32 339419 579 110249269
Gait inability 60.41 9.76 215 339236 136161 110113687
Hypophagia 60.33 9.76 320 339131 52306 110197542
Taste disorder 60.22 9.76 67 339384 65320 110184528
Intestinal angioedema 59.90 9.76 39 339412 1058 110248790
Finger deformity 59.84 9.76 14 339437 33078 110216770
Oedema 59.20 9.76 389 339062 209587 110040261
Eosinophilic bronchitis 59.05 9.76 31 339420 555 110249293
Intentional self-injury 58.21 9.76 21 339430 37408 110212440
Total lung capacity abnormal 58.01 9.76 71 339380 4512 110245336
Malignant neoplasm progression 57.36 9.76 308 339143 174259 110075589
Product monitoring error 56.87 9.76 100 339351 8827 110241021
Blood mercury abnormal 56.60 9.76 24 339427 258 110249590
Urticaria 55.33 9.76 669 338782 318188 109931660
Completed suicide 55.19 9.76 1048 338403 241333 110008515
Arrhythmia 53.74 9.76 382 339069 69193 110180655
Delirium 53.30 9.76 223 339228 134802 110115046
Leukopenia 53.16 9.76 255 339196 148536 110101312
Vitamin B1 decreased 52.79 9.76 34 339417 905 110248943
Renal artery stenosis 52.56 9.76 61 339390 3665 110246183
IgM nephropathy 52.02 9.76 19 339432 132 110249716
Red blood cell sedimentation rate abnormal 51.61 9.76 7 339444 24502 110225346
Metabolic alkalosis 51.27 9.76 74 339377 5521 110244327
Supraventricular extrasystoles 50.87 9.76 90 339361 7983 110241865
Product prescribing error 50.14 9.76 299 339152 51032 110198816
Influenza like illness 49.01 9.76 450 339001 87962 110161886
Pancreatitis 48.82 9.76 470 338981 93063 110156785
Electrolyte imbalance 48.66 9.76 234 339217 36794 110213054
Electrocardiogram abnormal 48.61 9.76 147 339304 18562 110231286
Pemphigoid 48.56 9.76 152 339299 19555 110230293
Product complaint 48.44 9.76 122 339329 13850 110235998
Drug-induced liver injury 48.20 9.76 197 339254 119870 110129978
Therapy partial responder 47.94 9.76 27 339424 37034 110212814
Disorientation 47.78 9.76 376 339075 70295 110179553
Systemic infection 47.70 9.76 98 339353 9721 110240127
Rash 47.36 9.76 2049 337402 818915 109430933
Haematochezia 46.95 9.76 552 338899 114972 110134876
Haemophagocytic lymphohistiocytosis 46.93 9.76 19 339432 31540 110218308
Cardiomegaly 46.48 9.76 195 339256 28935 110220913
Bronchopulmonary aspergillosis 46.03 9.76 17 339434 29846 110220002
Intestinal villi atrophy 45.62 9.76 26 339425 551 110249297
Ventricular hypertrophy 44.98 9.76 79 339372 6966 110242882
Pulmonary valve disease 44.97 9.76 22 339429 337 110249511
Tendon rupture 44.77 9.76 119 339332 13959 110235889
Myocardial ischaemia 44.44 9.76 181 339270 26503 110223345
Normal newborn 44.38 9.76 7 339444 21889 110227959
Back injury 44.28 9.76 48 339403 47351 110202497
Cough 44.08 9.76 1784 337667 459857 109789991
Orthostatic hypotension 43.98 9.76 351 339100 65898 110183950
Hyperlipidaemia 43.87 9.76 222 339229 35626 110214222
Mental status changes 43.49 9.76 390 339061 75732 110174116
Mitral valve incompetence 43.35 9.76 210 339241 33119 110216729
Glycosylated haemoglobin increased 43.20 9.76 165 339286 23454 110226394
Laryngitis 42.99 9.76 40 339411 42371 110207477
Epstein-Barr virus infection 42.86 9.76 4 339447 18734 110231114
Pericardial disease 42.68 9.76 27 339424 696 110249152
Dysphagia 42.43 9.76 685 338766 152915 110096933
Hepatic steatosis 42.42 9.76 276 339175 48555 110201293
Nasopharyngitis 42.12 9.76 906 338545 393455 109856393
Adverse reaction 42.12 9.76 19 339432 29575 110220273
Blood creatine phosphokinase increased 42.06 9.76 375 339076 72702 110177146
Multiple organ dysfunction syndrome 41.78 9.76 283 339168 151427 110098421
Cytomegalovirus infection reactivation 41.70 9.76 4 339447 18329 110231519
Procedural pain 41.27 9.76 217 339234 35348 110214500
Basal cell carcinoma 41.25 9.76 259 339192 45011 110204837
Hospitalisation 41.16 9.76 262 339189 142231 110107617
Injury 41.08 9.76 347 339104 176918 110072930
Blood pressure decreased 40.78 9.76 536 338915 114555 110135293
Adverse drug reaction 40.63 9.76 176 339275 105383 110144465
Cystitis 40.15 9.76 343 339108 65693 110184155
Aphasia 39.94 9.76 314 339137 58683 110191165
Eosinophilic granulomatosis with polyangiitis 39.90 9.76 96 339355 10590 110239258
Nail disorder 39.85 9.76 73 339378 57862 110191986
Renal tubular necrosis 39.62 9.76 192 339259 30283 110219565
Alkalosis hypochloraemic 39.42 9.76 24 339427 577 110249271
Interstitial lung disease 39.33 9.76 258 339193 139076 110110772
Anti-neutrophil cytoplasmic antibody positive vasculitis 38.89 9.76 64 339387 5353 110244495
Weight decreased 38.48 9.76 1781 337670 466276 109783572
Contusion 38.45 9.76 495 338956 232866 110016982
Mite allergy 38.26 9.76 66 339385 5737 110244111
Spirometry abnormal 38.20 9.76 64 339387 5433 110244415
Exostosis 38.19 9.76 51 339400 45905 110203943
Rotator cuff syndrome 38.17 9.76 126 339325 16668 110233180
Emotional distress 38.05 9.76 252 339199 44595 110205253
Anhedonia 38.01 9.76 119 339332 15309 110234539
Adverse event 37.41 9.76 189 339262 108620 110141228
Myalgia 37.27 9.76 920 338531 221461 110028387
Platelet count decreased 37.16 9.76 491 338960 229952 110019896
Incorrect route of product administration 37.10 9.76 89 339362 63972 110185876
5-hydroxyindolacetic acid in urine increased 36.78 9.76 16 339435 184 110249664
Weight increased 36.59 9.76 994 338457 418650 109831198
Sopor 36.42 9.76 35 339416 36511 110213337
Bacteraemia 36.30 9.76 46 339405 42344 110207504
Haematotoxicity 36.04 9.76 10 339441 21072 110228776
Photosensitivity reaction 36.03 9.76 165 339286 25424 110224424
Onychomycosis 36.01 9.76 39 339412 38492 110211356
Polyuria 35.87 9.76 128 339323 17610 110232238
Mycotic allergy 35.75 9.76 65 339386 5889 110243959
Forced expiratory volume decreased 35.63 9.76 105 339346 13071 110236777
Oedema peripheral 35.61 9.76 1288 338163 327372 109922476
Aspergillus infection 35.60 9.76 17 339434 25599 110224249
Dust allergy 35.39 9.76 65 339386 5936 110243912
Foetal death 35.21 9.76 4 339447 16041 110233807
Lupus-like syndrome 35.20 9.76 44 339407 40748 110209100
Acute myeloid leukaemia 35.15 9.76 39 339412 38071 110211777
Vitamin B1 increased 35.07 9.76 15 339436 165 110249683
Pneumocystis jirovecii pneumonia 34.93 9.76 48 339403 42687 110207161
Cardiac disorder 34.86 9.76 373 339078 75907 110173941
Cytopenia 34.76 9.76 25 339426 30091 110219757
Transplant rejection 34.61 9.76 16 339435 24551 110225297
Lymphocyte count decreased 34.38 9.76 78 339373 57165 110192683
Occult blood 34.24 9.76 35 339416 1821 110248027
Muscular weakness 34.23 9.76 1002 338449 247466 110002382
Actinic keratosis 34.08 9.76 70 339381 6943 110242905
Lichen planus 34.06 9.76 47 339404 3363 110246485
Choroidal detachment 33.94 9.76 24 339427 748 110249100
Thrombotic microangiopathy 33.90 9.76 24 339427 29125 110220723
Allergic oedema 33.85 9.76 26 339425 922 110248926
Antineutrophil cytoplasmic antibody positive 33.82 9.76 58 339393 5018 110244830
Shock 33.46 9.76 280 339171 53308 110196540
Left ventricular hypertrophy 33.42 9.76 103 339348 13141 110236707
Large intestine polyp 33.10 9.76 112 339339 15005 110234843
Venoocclusive liver disease 32.85 9.76 4 339447 15203 110234645
Sedation 32.80 9.76 107 339344 69576 110180272
Schizophrenia 32.68 9.76 13 339438 21813 110228035
Bronchomalacia 32.65 9.76 17 339434 299 110249549
Atrioventricular block 32.61 9.76 120 339331 16757 110233091
Chest discomfort 32.43 9.76 730 338721 173118 110076730
Hypoaesthesia 32.36 9.76 726 338725 313497 109936351
Bone marrow failure 32.22 9.76 82 339369 57766 110192082
Pancytopenia 32.22 9.76 451 339000 209162 110040686
Low density lipoprotein decreased 32.20 9.76 30 339421 1392 110248456
Influenza 32.15 9.76 712 338739 168389 110081459
Essential hypertension 32.03 9.76 73 339378 7774 110242074
Diverticulitis 32.01 9.76 277 339174 53245 110196603
Polydipsia 31.92 9.76 72 339379 7616 110242232
Ventricular extrasystoles 31.89 9.76 146 339305 22495 110227353
Dystonia 31.69 9.76 20 339431 25785 110224063
Infective pulmonary exacerbation of cystic fibrosis 31.63 9.76 4 339447 14767 110235081
Physical examination abnormal 31.60 9.76 20 339431 516 110249332
Myopathy 31.55 9.76 156 339295 24804 110225044
Normochromic normocytic anaemia 31.52 9.76 100 339351 12957 110236891
Obstructive airways disorder 31.45 9.76 246 339205 45903 110203945
Diverticulum 31.36 9.76 112 339339 15414 110234434
Conjunctivitis allergic 31.14 9.76 67 339384 6864 110242984
Atrioventricular block second degree 31.09 9.76 74 339377 8107 110241741
Neurological symptom 31.03 9.76 112 339339 15496 110234352
Erectile dysfunction 31.01 9.76 126 339325 18430 110231418
Musculoskeletal pain 30.97 9.76 386 339065 182637 110067211
Infusion site reaction 30.96 9.76 8 339443 17674 110232174
Heart rate decreased 30.83 9.76 389 339062 82367 110167481
Septic shock 30.66 9.76 322 339129 157206 110092642
Non-cardiogenic pulmonary oedema 30.56 9.76 34 339417 1950 110247898
Vascular purpura 30.44 9.76 47 339404 3724 110246124
Renal injury 30.43 9.76 126 339325 18587 110231261
Hepatic cirrhosis 30.35 9.76 106 339345 67520 110182328
Cutaneous lupus erythematosus 30.32 9.76 45 339406 3443 110246405
Graft versus host disease 30.20 9.76 10 339441 18796 110231052
Drug use disorder 30.11 9.76 9 339442 18065 110231783
Fear 30.06 9.76 146 339305 23047 110226801
Foot deformity 29.98 9.76 65 339386 48415 110201433
Distributive shock 29.96 9.76 60 339391 5844 110244004
Hypertensive heart disease 29.95 9.76 52 339399 4544 110245304
Heart rate irregular 29.33 9.76 193 339258 34081 110215767
Oral candidiasis 29.08 9.76 236 339215 44524 110205324
Vertigo 28.89 9.76 400 339051 86470 110163378
Peripheral vascular disorder 28.81 9.76 74 339377 8502 110241346
Angle closure glaucoma 28.79 9.76 44 339407 3455 110246393
Hyperglycaemia 28.79 9.76 393 339058 84697 110165151
Body temperature decreased 28.64 9.76 203 339248 36732 110213116
Fluid intake reduced 28.53 9.76 65 339386 6921 110242927
Blood creatine increased 28.51 9.76 89 339362 11432 110238416
Ulcer haemorrhage 28.40 9.76 17 339434 22554 110227294
Hip fracture 28.32 9.76 195 339256 34956 110214892
Electrocardiogram ST segment depression 28.31 9.76 56 339395 5405 110244443
Extrasystoles 28.18 9.76 72 339379 8246 110241602
Interstitial granulomatous dermatitis 28.06 9.76 15 339436 279 110249569
Blood cholesterol decreased 27.98 9.76 38 339413 2678 110247170
Neuroglycopenia 27.92 9.76 25 339426 1101 110248747
Dysgeusia 27.81 9.76 333 339118 69652 110180196
Chronic kidney disease 27.73 9.76 357 339094 75934 110173914
Peripheral circulatory failure 27.72 9.76 31 339420 1788 110248060
Premature delivery 27.54 9.76 32 339419 30600 110219248
Swollen tongue 27.51 9.76 295 339156 60067 110189781
Ear injury 27.50 9.76 16 339435 353 110249495
Squamous cell carcinoma 27.46 9.76 121 339330 18342 110231506
Haemorrhagic stroke 27.45 9.76 99 339352 13690 110236158
Mydriasis 27.45 9.76 17 339434 22140 110227708
Gastric disorder 27.44 9.76 186 339265 33171 110216677
Gastrointestinal disorder 27.24 9.76 551 338900 241401 110008447
Immune reconstitution inflammatory syndrome 27.18 9.76 8 339443 16218 110233630
Psoriasis 27.11 9.76 591 338860 139402 110110446
Cutaneous T-cell lymphoma 27.07 9.76 42 339409 3342 110246506
Disability 26.71 9.76 32 339419 30191 110219657
Neutropenic sepsis 26.71 9.76 33 339418 30713 110219135
Back pain 26.57 9.76 1393 338058 369603 109880245
Gouty arthritis 26.54 9.76 29 339422 1630 110248218
Kidney transplant rejection 26.28 9.76 3 339448 11984 110237864
Bladder prolapse 26.25 9.76 27 339424 1415 110248433
Choroidal infarction 26.18 9.76 13 339438 206 110249642
Acute coronary syndrome 26.12 9.76 140 339311 22972 110226876
Peripheral swelling 26.10 9.76 995 338456 403039 109846809
Bundle branch block right 25.98 9.76 90 339361 12201 110237647
Aplastic anaemia 25.75 9.76 22 339429 24286 110225562
Diarrhoea 25.72 9.76 3928 335523 1135577 109114271
Dementia 25.69 9.76 176 339275 31497 110218351
Diabetes mellitus inadequate control 25.68 9.76 168 339283 29607 110220241
Polyp 25.54 9.76 78 339373 9902 110239946
Hypocalcaemia 25.53 9.76 310 339141 65056 110184792
Hepatic neoplasm 25.52 9.76 44 339407 3823 110246025
Withdrawal hypertension 25.48 9.76 16 339435 407 110249441
Hypogammaglobulinaemia 25.43 9.76 15 339436 20061 110229787
Device related thrombosis 24.99 9.76 41 339410 3421 110246427
Aortic valve incompetence 24.61 9.76 82 339369 10899 110238949
Pollakiuria 24.51 9.76 225 339226 43970 110205878
Vascular device infection 24.46 9.76 10 339441 16502 110233346
Coronary artery bypass 24.43 9.76 56 339395 5986 110243862
Diabetic hyperosmolar coma 24.32 9.76 21 339430 881 110248967
Aspiration 24.25 9.76 35 339416 30498 110219350
Hypertension 24.17 9.76 1848 337603 508236 109741612
Dysuria 24.11 9.76 287 339164 59944 110189904
Knee arthroplasty 23.96 9.76 110 339341 64838 110185010
Coronary artery occlusion 23.94 9.76 104 339347 15668 110234180
Headache 23.83 9.76 3074 336377 879303 109370545
Agranulocytosis 23.75 9.76 103 339348 61657 110188191
Hepatojugular reflux 23.74 9.76 19 339432 716 110249132
Intervertebral disc protrusion 23.72 9.76 156 339295 27542 110222306
White blood cell count decreased 23.60 9.76 530 338921 228860 110020988
Toxicity to various agents 23.54 9.76 1220 338231 479335 109770513
Electrocardiogram Q wave abnormal 23.54 9.76 19 339432 725 110249123
Capillaritis 23.44 9.76 33 339418 2406 110247442
Joint destruction 23.34 9.76 3 339448 10940 110238908
Ear infection 23.29 9.76 106 339345 62626 110187222
Nervousness 23.24 9.76 193 339258 36658 110213190
Pharyngeal oedema 23.18 9.76 106 339345 16322 110233526
Multiple-drug resistance 23.15 9.76 6 339445 13229 110236619
Helicobacter gastritis 23.10 9.76 34 339417 2582 110247266
Diastolic dysfunction 22.97 9.76 87 339364 12317 110237531
Pernicious anaemia 22.88 9.76 19 339432 755 110249093
Device related infection 22.81 9.76 55 339396 39464 110210384
Nephrocalcinosis 22.79 9.76 28 339423 1786 110248062
Tricuspid valve incompetence 22.64 9.76 138 339313 23735 110226113
Aggression 22.61 9.76 99 339352 59111 110190737
Hallucination 22.53 9.76 437 339014 100995 110148853
Sleep apnoea syndrome 22.48 9.76 206 339245 40241 110209607
Stupor 22.48 9.76 66 339385 8199 110241649
Renin increased 22.44 9.76 14 339437 352 110249496
Pleural effusion 22.37 9.76 397 339054 177312 110072536
Respiratory symptom 22.27 9.76 98 339353 14847 110235001
Granulomatous pneumonitis 22.22 9.76 12 339439 228 110249620
Muscle spasticity 22.07 9.76 187 339264 35728 110214120
Microalbuminuria 22.04 9.76 23 339428 1226 110248622
Miosis 21.97 9.76 21 339430 21962 110227886
Endometrial cancer stage I 21.73 9.76 11 339440 182 110249666
Walking aid user 21.69 9.76 27 339424 25048 110224800
Overdose 21.62 9.76 549 338902 233245 110016603
Neurosensory hypoacusis 21.45 9.76 12 339439 245 110249603
Vulvovaginal burning sensation 21.39 9.76 29 339422 2040 110247808
Cardiac discomfort 21.19 9.76 24 339427 1404 110248444
Substance abuse 21.14 9.76 6 339445 12457 110237391
Disseminated intravascular coagulation 21.13 9.76 61 339390 41225 110208623
Sinusitis 21.11 9.76 722 338729 295966 109953882
Amaurosis fugax 21.01 9.76 31 339420 2359 110247489
Multiple drug therapy 20.85 9.76 63 339388 7951 110241897
Meniere's disease 20.81 9.76 10 339441 147 110249701
Mucosal inflammation 20.59 9.76 192 339259 95949 110153899
Acquired acrodermatitis enteropathica 20.50 9.76 5 339446 5 110249843
Cystitis haemorrhagic 20.49 9.76 6 339445 12203 110237645
Haemodialysis 20.48 9.76 108 339343 17611 110232237
Haematocrit decreased 20.21 9.76 300 339151 65817 110184031
Tooth erosion 20.21 9.76 14 339437 422 110249426
Visual impairment 20.14 9.76 548 338903 133880 110115968
Bronchiectasis 20.12 9.76 52 339399 36441 110213407
Meniscus injury 20.03 9.76 61 339390 7732 110242116
Polymyalgia rheumatica 20.03 9.76 54 339397 6388 110243460
Gastric polyps 19.96 9.76 49 339402 5474 110244374
Adenocarcinoma 19.95 9.76 42 339409 4238 110245610
Gastrointestinal tract mucosal pigmentation 19.87 9.76 22 339429 1255 110248593
Lacunar infarction 19.85 9.76 53 339398 6233 110243615
Full blood count abnormal 19.83 9.76 261 339190 55791 110194057
Toxic epidermal necrolysis 19.80 9.76 98 339353 56629 110193219
Echocardiogram abnormal 19.75 9.76 32 339419 2642 110247206
Fibrous histiocytoma 19.58 9.76 18 339433 821 110249027
Seronegative arthritis 19.48 9.76 8 339443 13169 110236679
Myelodysplastic syndrome 19.47 9.76 55 339396 37429 110212419
Ischaemic stroke 19.43 9.76 203 339248 41060 110208788
Rhinovirus infection 19.41 9.76 6 339445 11783 110238065
Eosinophilic cellulitis 19.40 9.76 12 339439 297 110249551
Torsade de pointes 19.18 9.76 127 339324 22473 110227375
Carotid arteriosclerosis 19.16 9.76 34 339417 3023 110246825
Neoplasm 19.10 9.76 76 339375 11011 110238837
Low density lipoprotein increased 19.09 9.76 74 339377 10592 110239256
5-hydroxyindolacetic acid increased 19.06 9.76 9 339442 127 110249721
Neurotoxicity 19.05 9.76 66 339385 42141 110207707
Erythrodermic psoriasis 19.03 9.76 27 339424 1983 110247865
Pustular psoriasis 18.95 9.76 9 339442 13596 110236252
Thalamic infarction 18.85 9.76 22 339429 1330 110248518
Renal artery stent placement 18.79 9.76 8 339443 87 110249761
Parathyroid disorder 18.78 9.76 16 339435 659 110249189
Pseudolymphoma 18.74 9.76 21 339430 1214 110248634
Respiratory disorder 18.74 9.76 135 339316 71247 110178601
Akathisia 18.73 9.76 15 339436 17098 110232750
Renovascular hypertension 18.55 9.76 8 339443 90 110249758
Progressive multifocal leukoencephalopathy 18.48 9.76 30 339421 24926 110224922
Dermatitis atopic 18.44 9.76 138 339313 25403 110224445
Pseudomonas infection 18.36 9.76 36 339415 27817 110222031
Neurofibrosarcoma 18.35 9.76 11 339440 257 110249591
Febrile bone marrow aplasia 18.27 9.76 16 339435 17449 110232399
Gout 18.22 9.76 182 339269 36384 110213464
Dilatation atrial 18.19 9.76 38 339413 3814 110246034
Arthritis 18.19 9.76 657 338794 166929 110082919
Eosinophilia 18.15 9.76 264 339187 57672 110192176
Hypertensive angiopathy 18.09 9.76 8 339443 96 110249752
Respiratory tract inflammation 18.04 9.76 19 339432 1024 110248824
Immunodeficiency 18.02 9.76 60 339391 38778 110211070
BRASH syndrome 17.90 9.76 37 339414 3686 110246162
Metastases to fallopian tube 17.80 9.76 7 339444 61 110249787
Gastrointestinal toxicity 17.77 9.76 6 339445 11142 110238706
Appendicitis 17.74 9.76 38 339413 28426 110221422
Subacute cutaneous lupus erythematosus 17.73 9.76 44 339407 4950 110244898
End stage renal disease 17.67 9.76 24 339427 21449 110228399
Sedation complication 17.57 9.76 21 339430 19834 110230014
Pulmonary alveolar haemorrhage 17.56 9.76 114 339337 20036 110229812
Cholelithiasis 17.56 9.76 283 339168 63139 110186709
Urinary incontinence 17.51 9.76 227 339224 48360 110201488
Intervertebral disc degeneration 17.44 9.76 105 339346 17980 110231868
Coronary artery stenosis 17.40 9.76 86 339365 13672 110236176
Sickle cell anaemia with crisis 17.33 9.76 4 339447 9541 110240307
Respiratory depression 17.33 9.76 46 339405 31955 110217893
Peptic ulcer 17.17 9.76 57 339394 7562 110242286
Cognitive disorder 17.11 9.76 370 339081 87141 110162707
Vulvovaginal pruritus 17.08 9.76 34 339417 3297 110246551
Intercapillary glomerulosclerosis 17.06 9.76 8 339443 111 110249737
Device expulsion 17.04 9.76 44 339407 30847 110219001
Gastrointestinal angiodysplasia 17.02 9.76 20 339431 1218 110248630
Bradypnoea 17.01 9.76 3 339448 8646 110241202
Spinal osteoarthritis 16.87 9.76 113 339338 20070 110229778
Muscle necrosis 16.81 9.76 24 339427 1773 110248075
Mandibular mass 16.70 9.76 10 339441 233 110249615
Epiploic appendagitis 16.67 9.76 9 339442 171 110249677
Shock hypoglycaemic 16.63 9.76 10 339441 235 110249613
Accelerated hypertension 16.49 9.76 16 339435 781 110249067
Mitral valve disease 16.42 9.76 34 339417 3391 110246457
Drug tolerance 16.39 9.76 16 339435 16569 110233279
Deafness 16.38 9.76 139 339312 26570 110223278
Depressive symptom 16.37 9.76 3 339448 8411 110241437
Product substitution issue 16.31 9.76 124 339327 22937 110226911
Shoshin beriberi 16.29 9.76 7 339444 78 110249770
International normalised ratio decreased 16.29 9.76 59 339392 8177 110241671
Iodine allergy 16.28 9.76 15 339436 686 110249162
Endometrial hyperplasia 16.26 9.76 15 339436 687 110249161
Cholestasis 16.08 9.76 283 339168 64235 110185613
Breast neoplasm 16.07 9.76 18 339433 1040 110248808
Nodular rash 16.07 9.76 11 339440 325 110249523
Non-cardiac chest pain 16.06 9.76 68 339383 10130 110239718
Depressed level of consciousness 16.05 9.76 245 339206 112033 110137815
Crystal arthropathy 15.94 9.76 10 339441 254 110249594
Blood growth hormone increased 15.93 9.76 18 339433 1050 110248798
Injection site inflammation 15.86 9.76 41 339410 4730 110245118
Prescribed underdose 15.81 9.76 126 339325 65048 110184800
Oropharyngeal swelling 15.76 9.76 21 339430 1453 110248395
Blood osmolarity decreased 15.72 9.76 21 339430 1457 110248391
Ventricular arrhythmia 15.68 9.76 67 339384 10020 110239828
Product administration error 15.63 9.76 179 339272 37038 110212810
Electrocardiogram U-wave abnormality 15.61 9.76 7 339444 87 110249761
Vision blurred 15.55 9.76 512 338939 128510 110121338
Cerebral ischaemia 15.55 9.76 76 339375 12028 110237820
Enterococcal infection 15.54 9.76 24 339427 20342 110229506
Prerenal failure 15.53 9.76 39 339412 4420 110245428
Cell death 15.52 9.76 46 339405 5745 110244103
Jaw disorder 15.52 9.76 43 339408 5169 110244679
Visual acuity reduced 15.49 9.76 159 339292 32014 110217834
Supraventricular tachycardia 15.45 9.76 128 339323 24294 110225554
Electrocardiogram QT prolonged 15.43 9.76 441 339010 108519 110141329
Gastritis 15.39 9.76 241 339210 53458 110196390
Mucosal membrane hyperplasia 15.18 9.76 6 339445 53 110249795
Angiopathy 15.16 9.76 60 339391 8670 110241178
Eosinophilia myalgia syndrome 15.13 9.76 4 339447 7 110249841
Expired product administered 15.12 9.76 58 339393 8262 110241586
Lipohypertrophy 15.09 9.76 17 339434 989 110248859
Osteonecrosis of jaw 15.06 9.76 86 339365 47931 110201917
Pancreatitis necrotising 15.03 9.76 44 339407 5457 110244391
Tachycardia 15.02 9.76 845 338606 225800 110024048
Tooth abscess 15.00 9.76 104 339347 18685 110231163
Pruritus allergic 14.99 9.76 22 339429 1666 110248182
Coronary arterial stent insertion 14.92 9.76 46 339405 5869 110243979
Immune effector cell-associated neurotoxicity syndrome 14.91 9.76 14 339437 14768 110235080
Renal artery angioplasty 14.90 9.76 5 339446 26 110249822
Rebound tachycardia 14.90 9.76 5 339446 26 110249822
Preternatural anus 14.87 9.76 7 339444 98 110249750
Melaena 14.85 9.76 295 339156 68462 110181386
Anaphylactic reaction 14.81 9.76 254 339197 114046 110135802
Osteogenesis imperfecta 14.78 9.76 15 339436 774 110249074
Amnesia 14.75 9.76 426 339025 104982 110144866
Blood hyposmosis 14.75 9.76 5 339446 27 110249821
Peritonitis 14.71 9.76 51 339400 32556 110217292
Allergic cough 14.69 9.76 17 339434 1018 110248830
Injection site extravasation 14.64 9.76 66 339385 10103 110239745
Renal impairment 14.59 9.76 713 338738 187732 110062116
Psychotic disorder 14.53 9.76 94 339357 50843 110199005
Endometrial disorder 14.52 9.76 14 339437 678 110249170
Recalled product 14.49 9.76 17 339434 1033 110248815
Hot flush 14.49 9.76 284 339167 65752 110184096
Gastrointestinal haemorrhage 14.48 9.76 634 338817 164884 110084964
Hyponatraemic encephalopathy 14.40 9.76 11 339440 387 110249461
Blood triglycerides increased 14.40 9.76 124 339327 23802 110226046
Vasoplegia syndrome 14.38 9.76 43 339408 5396 110244452
Colorectal cancer 14.37 9.76 5 339446 9109 110240739
Bacterial sepsis 14.36 9.76 7 339444 10419 110239429
Pathological fracture 14.36 9.76 74 339377 11958 110237890
Rhinalgia 14.35 9.76 35 339416 3894 110245954
Hypotonia 14.29 9.76 90 339361 15655 110234193
Cortisol free urine increased 14.19 9.76 6 339445 64 110249784
Cerebellar cognitive affective syndrome 14.18 9.76 4 339447 10 110249838
Fatigue 14.14 9.76 4060 335391 1211898 109037950
Dyspnoea 14.09 9.76 3710 335741 1103162 109146686
Cerebellar syndrome 14.07 9.76 47 339404 6255 110243593
Carpal tunnel syndrome 14.04 9.76 118 339333 22492 110227356
Lymphomatoid papulosis 13.99 9.76 11 339440 404 110249444
Hypersensitivity vasculitis 13.98 9.76 50 339401 6887 110242961
Haemorrhagic fever 13.91 9.76 5 339446 33 110249815
Injection site reaction 13.91 9.76 191 339260 88879 110160969
Parkinsonism 13.89 9.76 116 339335 22071 110227777
Hepatitis B reactivation 13.87 9.76 3 339448 7481 110242367
Rhinorrhoea 13.85 9.76 413 339038 102253 110147595
Immune-mediated enterocolitis 13.79 9.76 7 339444 10178 110239670
Carotid bruit 13.78 9.76 14 339437 723 110249125
Forced vital capacity decreased 13.77 9.76 23 339428 1947 110247901
Anaphylactic shock 13.77 9.76 97 339354 51449 110198399
Oesophageal discomfort 13.74 9.76 12 339439 511 110249337
Hypopnoea 13.73 9.76 9 339442 11371 110238477
Renal artery restenosis 13.65 9.76 4 339447 12 110249836
International normalised ratio increased 13.65 9.76 356 339095 86416 110163432
Injection site hypersensitivity 13.62 9.76 26 339425 2445 110247403
Skin laceration 13.58 9.76 161 339290 33592 110216256
Blood pressure systolic abnormal 13.52 9.76 126 339325 24724 110225124
Presyncope 13.48 9.76 218 339233 48669 110201179
Potentiating drug interaction 13.48 9.76 71 339380 11572 110238276
Head injury 13.47 9.76 196 339255 42821 110207027
Inappropriate schedule of product administration 13.46 9.76 500 338951 203137 110046711
Flank pain 13.46 9.76 119 339332 23011 110226837
Troponin I increased 13.38 9.76 42 339409 5410 110244438
Device dislocation 13.37 9.76 51 339400 31653 110218195
Blood test abnormal 13.33 9.76 44 339407 28510 110221338
Pathogen resistance 13.32 9.76 21 339430 17651 110232197
Renin decreased 13.30 9.76 7 339444 126 110249722
Maternal exposure before pregnancy 13.28 9.76 3 339448 7262 110242586
White blood cell count abnormal 13.25 9.76 49 339402 6860 110242988
Trigger finger 13.22 9.76 40 339411 5052 110244796
Noninfective gingivitis 13.21 9.76 23 339428 2014 110247834
Small cell carcinoma 13.21 9.76 10 339441 347 110249501
Metastases to lymph nodes 13.20 9.76 16 339435 15016 110234832
Gallbladder disorder 13.19 9.76 110 339341 20919 110228929
Lymphopenia 13.12 9.76 71 339380 40099 110209749
COVID-19 pneumonia 13.06 9.76 64 339387 37079 110212769
Glomerular filtration rate decreased 12.95 9.76 141 339310 28815 110221033
Rectal prolapse 12.95 9.76 26 339425 2537 110247311
Pneumatosis intestinalis 12.90 9.76 5 339446 8524 110241324
Rheumatoid factor 12.89 9.76 12 339439 556 110249292
Diabetic neuropathy 12.89 9.76 49 339402 6950 110242898
Laryngeal pain 12.85 9.76 44 339407 5931 110243917
Iatrogenic injury 12.78 9.76 20 339431 1603 110248245
Coronary artery restenosis 12.77 9.76 17 339434 1175 110248673
Dementia Alzheimer's type 12.76 9.76 15 339436 914 110248934
Flatulence 12.73 9.76 228 339223 51921 110197927
Hyperammonaemia 12.72 9.76 14 339437 13718 110236130
Blood potassium increased 12.68 9.76 157 339294 33092 110216756
Cytomegalovirus test positive 12.68 9.76 3 339448 7033 110242815
Hemiataxia 12.67 9.76 5 339446 44 110249804
Macrocytosis 12.66 9.76 30 339421 3277 110246571
Sinus arrest 12.63 9.76 35 339416 4207 110245641
Hypothyroidism 12.63 9.76 303 339148 72596 110177252
Blood parathyroid hormone decreased 12.63 9.76 76 339375 13013 110236835
Hiatus hernia 12.61 9.76 135 339316 27471 110222377
Overlap syndrome 12.61 9.76 6 339445 9053 110240795
Pseudomonal sepsis 12.58 9.76 6 339445 9040 110240808
Electrocardiogram Q waves 12.56 9.76 6 339445 87 110249761
Electrocardiogram T wave amplitude decreased 12.53 9.76 14 339437 807 110249041
Gastrooesophageal reflux disease 12.51 9.76 674 338777 179302 110070546
Initial insomnia 12.48 9.76 64 339387 10325 110239523
Cholecystitis chronic 12.45 9.76 60 339391 9440 110240408
Tubulointerstitial nephritis 12.44 9.76 235 339216 54049 110195799
Carcinoid tumour of the gastrointestinal tract 12.34 9.76 7 339444 147 110249701
Blood immunoglobulin M abnormal 12.34 9.76 7 339444 147 110249701
Prothrombin time prolonged 12.31 9.76 93 339358 17168 110232680
Injection site discolouration 12.30 9.76 58 339393 9045 110240803
Hyperchloruria 12.30 9.76 3 339448 3 110249845
Hypermagnesuria 12.30 9.76 3 339448 3 110249845
Paresis cranial nerve 12.29 9.76 5 339446 48 110249800
Deep vein thrombosis 12.28 9.76 536 338915 139351 110110497
Upper-airway cough syndrome 12.20 9.76 87 339364 15770 110234078
Post-anoxic myoclonus 12.20 9.76 5 339446 49 110249799
Allergic hepatitis 12.20 9.76 5 339446 49 110249799
Foreign body in reproductive tract 12.18 9.76 15 339436 959 110248889
Gait disturbance 12.18 9.76 1002 338449 277206 109972642
Hyperlactacidaemia 12.09 9.76 54 339397 8232 110241616
Clostridium difficile infection 12.09 9.76 102 339349 52027 110197821
Adiposis dolorosa 12.07 9.76 9 339442 305 110249543
Tumour lysis syndrome 12.07 9.76 51 339400 30750 110219098
Nodal arrhythmia 12.06 9.76 23 339428 2161 110247687
Azotaemia 12.02 9.76 62 339389 10023 110239825
No adverse event 12.01 9.76 157 339294 73682 110176166
Blood follicle stimulating hormone increased 11.96 9.76 10 339441 401 110249447
Body height decreased 11.95 9.76 64 339387 10499 110239349
Metabolic syndrome 11.94 9.76 29 339422 3218 110246630
Cerebellar infarction 11.93 9.76 34 339417 4153 110245695
Staring 11.91 9.76 27 339424 2865 110246983
Gastrointestinal mucosal necrosis 11.88 9.76 8 339443 230 110249618
Weight fluctuation 11.87 9.76 32 339419 22113 110227735
Hyperphosphataemia 11.84 9.76 20 339431 16361 110233487
Confabulation 11.81 9.76 11 339440 510 110249338
Lung opacity 11.80 9.76 11 339440 11641 110238207
Suicide attempt 11.77 9.76 235 339216 103159 110146689
Injection site hypertrophy 11.76 9.76 6 339445 101 110249747
Intraductal papilloma of breast 11.74 9.76 7 339444 162 110249686
Osmotic demyelination syndrome 11.73 9.76 22 339429 2041 110247807
Pneumothorax 11.72 9.76 62 339389 35223 110214625
Aortic valve sclerosis 11.71 9.76 21 339430 1882 110247966
Product administered to patient of inappropriate age 11.69 9.76 5 339446 8031 110241817
Retroperitoneal fibrosis 11.67 9.76 13 339438 747 110249101
Haemarthrosis 11.64 9.76 49 339402 7280 110242568
Pneumonia fungal 11.63 9.76 17 339434 14737 110235111
Neuralgia 11.63 9.76 94 339357 48384 110201464
Lip infection 11.58 9.76 7 339444 166 110249682
Asphyxia 11.58 9.76 16 339435 14199 110235649
Therapeutic response unexpected 11.56 9.76 118 339333 23725 110226123
Thrombosis 11.54 9.76 425 339026 108237 110141611
Tooth disorder 11.54 9.76 140 339311 29369 110220479
Ischaemic cardiomyopathy 11.54 9.76 52 339399 7959 110241889
Dilatation ventricular 11.52 9.76 33 339418 4042 110245806
Seizure 11.49 9.76 558 338893 220627 110029221
Red blood cell sedimentation rate increased 11.49 9.76 170 339281 78132 110171716
Blood pressure fluctuation 11.48 9.76 306 339145 74518 110175330
Craniofacial fracture 11.47 9.76 14 339437 887 110248961
Parotitis 11.42 9.76 28 339423 3125 110246723
Renal function test abnormal 11.37 9.76 56 339395 8890 110240958
Renal cyst 11.37 9.76 95 339356 18077 110231771
Lipase increased 11.36 9.76 97 339354 18575 110231273
Poisoning deliberate 11.33 9.76 42 339409 26289 110223559
Cyanopsia 11.30 9.76 6 339445 110 110249738
Atrophy 11.28 9.76 24 339427 2440 110247408
Hyperlipasaemia 11.24 9.76 18 339433 1471 110248377
Bladder irrigation 11.23 9.76 5 339446 61 110249787
Device leakage 11.23 9.76 20 339431 16028 110233820
Enterocolitis 11.23 9.76 26 339425 18923 110230925
Kyphosis 11.23 9.76 28 339423 3159 110246689
Diabetic retinopathy 11.20 9.76 30 339421 3534 110246314
Abdominal tenderness 11.18 9.76 71 339380 12386 110237462
Cardiac flutter 11.18 9.76 41 339410 5716 110244132
Alkalosis hypokalaemic 11.18 9.76 4 339447 26 110249822
Malignant hypertension 11.18 9.76 19 339432 1632 110248216
Uveitis 11.17 9.76 32 339419 21678 110228170
Neck pain 11.15 9.76 290 339161 122840 110127008
Pneumothorax spontaneous 11.12 9.76 20 339431 1797 110248051
Bronchopulmonary aspergillosis allergic 11.10 9.76 6 339445 8420 110241428
Good syndrome 11.09 9.76 3 339448 6 110249842
Device difficult to use 10.99 9.76 26 339425 18779 110231069
Exposure to toxic agent 10.96 9.76 14 339437 12844 110237004
Medication error 10.96 9.76 243 339208 105123 110144725
Burns second degree 10.95 9.76 5 339446 7728 110242120
Cytomegalovirus colitis 10.92 9.76 4 339447 7057 110242791
Breast pain 10.91 9.76 60 339391 9940 110239908
Product commingling 10.88 9.76 6 339445 119 110249729
Vestibular neuronitis 10.85 9.76 14 339437 939 110248909
Immunosuppression 10.82 9.76 24 339427 17735 110232113
Immunosuppressant drug level increased 10.81 9.76 12 339439 11712 110238136
Skin discolouration 10.78 9.76 211 339240 48835 110201013
Wound treatment 10.78 9.76 7 339444 189 110249659
Thirst decreased 10.74 9.76 9 339442 362 110249486
Pulpitis dental 10.72 9.76 18 339433 1531 110248317
Fibrocystic breast disease 10.71 9.76 12 339439 694 110249154
Parainfluenzae virus infection 10.70 9.76 4 339447 6970 110242878
Choroidal haemorrhage 10.68 9.76 7 339444 192 110249656
Gastroduodenal ulcer 10.64 9.76 14 339437 957 110248891
Glomerulonephritis rapidly progressive 10.63 9.76 22 339429 2193 110247655
Renal artery arteriosclerosis 10.62 9.76 5 339446 70 110249778
Breath sounds abnormal 10.59 9.76 122 339329 25282 110224566
Device occlusion 10.56 9.76 19 339432 15166 110234682
Intervertebral disc displacement 10.55 9.76 10 339441 474 110249374
Nasal dryness 10.55 9.76 40 339411 5666 110244182
Unevaluable event 10.51 9.76 247 339204 58980 110190868
Haematoma muscle 10.50 9.76 32 339419 4058 110245790
Occult blood positive 10.48 9.76 48 339403 7397 110242451
Hyperkeratosis 10.46 9.76 56 339395 9183 110240665
Micturition disorder 10.46 9.76 35 339416 4663 110245185
High density lipoprotein decreased 10.44 9.76 40 339411 5693 110244155
Breast calcifications 10.43 9.76 14 339437 976 110248872
Incontinence 10.42 9.76 87 339364 16548 110233300
Oesophageal carcinoma 10.40 9.76 12 339439 11512 110238336
Mouth ulceration 10.36 9.76 96 339355 48042 110201806
Manufacturing materials contamination 10.36 9.76 4 339447 33 110249815
Acute myopia 10.34 9.76 7 339444 203 110249645
Anaemia postoperative 10.32 9.76 20 339431 1901 110247947
Nerve compression 10.32 9.76 64 339387 11073 110238775
Gastrointestinal perforation 10.28 9.76 5 339446 7451 110242397
Product residue present 10.27 9.76 31 339420 3910 110245938
Paradoxical drug reaction 10.26 9.76 9 339442 9808 110240040
Cardiac valve disease 10.26 9.76 43 339408 6378 110243470
Diverticulum oesophageal 10.25 9.76 7 339444 206 110249642
Drug dose omission by device 10.24 9.76 18 339433 14498 110235350
Hepatotoxicity 10.24 9.76 135 339316 63265 110186583
Pneumonia staphylococcal 10.21 9.76 3 339448 6088 110243760
Coma 10.20 9.76 451 339000 117418 110132430
Hallucination, auditory 10.16 9.76 44 339407 26353 110223495
Activated partial thromboplastin time 10.16 9.76 4 339447 35 110249813
Antidiuretic hormone abnormality 10.14 9.76 5 339446 78 110249770
Mesenteric vascular insufficiency 10.09 9.76 6 339445 138 110249710
Metastases to central nervous system 10.08 9.76 36 339415 22781 110227067
Metastatic renal cell carcinoma 10.04 9.76 23 339428 2457 110247391
Spondylitis 10.03 9.76 12 339439 11326 110238522
Precancerous skin lesion 10.02 9.76 18 339433 1616 110248232
Congestive hepatopathy 9.99 9.76 37 339414 5183 110244665
Forced expiratory flow decreased 9.99 9.76 8 339443 302 110249546
Needle issue 9.98 9.76 91 339360 17749 110232099
Cardiac failure acute 9.98 9.76 39 339412 24039 110225809
Hypervitaminosis D 9.98 9.76 6 339445 141 110249707
Nodal rhythm 9.95 9.76 28 339423 3395 110246453
Blood pressure abnormal 9.94 9.76 109 339342 22315 110227533
Aortic valve calcification 9.92 9.76 13 339438 885 110248963
Device use error 9.91 9.76 8 339443 9081 110240767
Skin toxicity 9.87 9.76 13 339438 11770 110238078
Osteitis deformans 9.85 9.76 7 339444 220 110249628
Urine sodium increased 9.85 9.76 7 339444 220 110249628
Blood aldosterone increased 9.85 9.76 7 339444 220 110249628
Hyperparathyroidism primary 9.80 9.76 10 339441 519 110249329
Feeling hot 9.80 9.76 209 339242 90897 110158951

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03AA03 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, plain
ATC C03AB03 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides and potassium in combination
ATC C03AX01 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, combinations with other drugs
ATC C03EA01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Low-ceiling diuretics and potassium-sparing agents
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09DX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX08 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09XA52 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C09XA54 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
FDA CS M0471776 Thiazides
FDA PE N0000175359 Increased Diuresis
FDA EPC N0000175419 Thiazide Diuretic
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D045283 Natriuretic Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D049993 Sodium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35498 diuretic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

C03AA Thiazides, plain 9 drugs
bendroflumethiazidechlorothiazidecyclopenthiazidecyclothiazidehydroflumethiazidemebutizidemethylclothiazidepolythiazidetrichlormethiazide
C03AB Thiazides and potassium in combination 8 drugs
bendroflumethiazidechlorothiazidecyclopenthiazidecyclothiazidehydroflumethiazidemethylclothiazidepolythiazidetrichlormethiazide
C03EA Low-ceiling diuretics and potassium-sparing agents 9 drugs
altizidebendroflumethiazidebutizidechlortalidonecyclopenthiazideepitizidemebutizidemetolazonetrichlormethiazide
C09BX ACE inhibitors, other combinations 7 drugs
amlodipinebisoprololindapamidenebivololperindoprilramiprilzofenopril
C09DX Angiotensin II receptor blockers (ARBs), other combinations 10 drugs
aliskirenamlodipinecandesartan cilexetilindapamideirbesartannebivolololmesartan medoxomilsacubitriltelmisartanvalsartan
C09XA Renin-inhibitors 3 drugs
aliskirenamlodipineremikiren

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Edema indication 267038008
Hypertensive urgency indication 443482000
Pulmonary Edema due to Chronic Heart Failure indication
Peripheral Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Hypertension with Left Ventricular Hypertrophy indication
Edema due to Nephrotic Syndrome indication
Nephrogenic diabetes insipidus off-label use 111395007 DOID:12387
Calcium renal calculus off-label use 427649000
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Suicidal thoughts contraindication 6471006
Psoriasis contraindication 9014002 DOID:8893
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Chronic disease of respiratory system contraindication 17097001
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Jaundice contraindication 18165001
Cirrhosis of liver contraindication 19943007 DOID:5082
Secondary angle-closure glaucoma contraindication 21571006
Electroconvulsive therapy contraindication 23835007
Acute vomiting contraindication 23971007
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Obstruction of bile duct contraindication 30144000
Parkinsonism contraindication 32798002
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Acute hepatitis contraindication 37871000
Immunosuppression contraindication 38013005
Anaphylaxis contraindication 39579001
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Sinus bradycardia contraindication 49710005
Cough contraindication 49727002
Acidosis contraindication 51387008
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Aortic valve stenosis contraindication 60573004 DOID:1712
Chronic bronchitis contraindication 63480004 DOID:6132
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Benign intracranial hypertension contraindication 68267002 DOID:11459
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Oliguria contraindication 83128009
Epilepsy contraindication 84757009 DOID:1826
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Kidney stone contraindication 95570007
Disorder of connective tissue contraindication 105969002 DOID:65
Diabetic renal disease contraindication 127013003
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Asthma contraindication 195967001 DOID:2841
Acute hepatic failure contraindication 197270009
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Disorder of electrolytes contraindication 237840007
Lupus erythematosus and erythema multiforme-like syndrome contraindication 238926009
Rhabdomyolysis contraindication 240131006
Raynaud's phenomenon contraindication 266261006
Calculus in biliary tract contraindication 266474003
Anemia contraindication 271737000 DOID:2355
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Pheochromocytoma contraindication 302835009
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Severe chronic obstructive pulmonary disease contraindication 313299006
Right ventricular failure contraindication 367363000
Surgical procedure contraindication 387713003
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Severe diarrhea contraindication 409587002
Autoimmune hemolytic anemia contraindication 413603009 DOID:718
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Porphyria contraindication 418470004
Intraoperative floppy iris syndrome contraindication 418801006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
First Degree Atrioventricular Heart Block contraindication
Intestinal Angioedema contraindication
Severe Aortic Valve Stenosis contraindication
Hemodialysis with High-Flux Membrane contraindication
Head and Neck Angioedema contraindication
Severe Cerebrovascular Disease contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Postparturient udder edema Indication

🐶 Veterinary products

ProductApplicantIngredients
Hydrozide Injection Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.89 acidic
pKa2 11.02 acidic
pKa3 0.71 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/ML INZIRQO NOVITIUM PHARMA N219141 Jan. 28, 2025 RX FOR SUSPENSION ORAL 11878022 Jan. 23, 2044 TREATMENT OF EDEMA IN PATIENTS WHO ARE IN NEED OF AN ORAL LIQUID SUSPENSION OF HYDROCHLOROTHIAZIDE
10MG/ML INZIRQO NOVITIUM PHARMA N219141 Jan. 28, 2025 RX FOR SUSPENSION ORAL 11878022 Jan. 23, 2044 TREATMENT OF HYPERTENSION IN PATIENTS WHO ARE IN NEED OF AN ORAL LIQUID SUSPENSION OF HYDROCHLOROTHIAZIDE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 12 member 3 Transporter INHIBITOR A2 7.01 WOMBAT-PK CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.90 WOMBAT-PK
Carbonic anhydrase 1 Enzyme Ki 6.48 CHEMBL
Carbonic anhydrase 4 Enzyme WOMBAT-PK
Calcium-activated potassium channel subunit alpha-1 Ion channel WOMBAT-PK
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D Enzyme ALLOSTERIC MODULATOR Kd 6.13 IUPHAR
Astrosclerin-3 Enzyme Ki 6.40 CHEMBL
Delta carbonic anhydrase Enzyme Ki 5.37 CHEMBL
Carbonic anhydrase, alpha family Enzyme Ki 6.53 CHEMBL
Carbonate dehydratase Enzyme Ki 8.14 CHEMBL
Carbonic anhydrase Enzyme Ki 7.50 CHEMBL

External reference:

IDSource
4017615 VUID
N0000145995 NUI
D00340 KEGG_DRUG
4017615 VANDF
C0020261 UMLSCUI
CHEBI:5778 CHEBI
CHEMBL435 ChEMBL_ID
CHEMBL15605 ChEMBL_ID
CHEMBL43686 ChEMBL_ID
DB00999 DRUGBANK_ID
D006852 MESH_DESCRIPTOR_UI
3639 PUBCHEM_CID
4836 IUPHAR_LIGAND_ID
841 INN_ID
0J48LPH2TH UNII
5487 RXNORM
4834 MMSL
924 MMSL
d00253 MMSL
002294 NDDF
387525002 SNOMEDCT_US
91667005 SNOMEDCT_US
HCZ PDB_CHEM_ID
0J48LPH2TH INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5855 TABLET, FILM COATED 12.50 mg ORAL NDA 29 sections
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5855 TABLET, FILM COATED 12.50 mg ORAL NDA 29 sections
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5856 TABLET, FILM COATED 12.50 mg ORAL NDA 29 sections
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5856 TABLET, FILM COATED 12.50 mg ORAL NDA 29 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0254 TABLET 12.50 mg ORAL ANDA 27 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0254 TABLET 12.50 mg ORAL ANDA 27 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0255 TABLET 12.50 mg ORAL ANDA 27 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0255 TABLET 12.50 mg ORAL ANDA 27 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0256 TABLET 25 mg ORAL ANDA 27 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0256 TABLET 25 mg ORAL ANDA 27 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0314 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0315 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0383 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0471 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0472 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0559 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0560 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0561 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0562 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0563 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3241 TABLET, FILM COATED 6.25 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3242 TABLET, FILM COATED 6.25 mg ORAL NDA authorized generic 23 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3243 TABLET, FILM COATED 6.25 mg ORAL NDA authorized generic 23 sections
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 3 0093-5002 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 3 0093-5003 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 3 0093-5004 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 3 0093-5005 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 3 0093-5006 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Losartan Potassium and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-7367 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Losartan Potassium and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-7368 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections