hydrochlorothiazide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 1385 58-93-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrochlorothiazide
  • hydrochlorothiazid
  • hydrochlorthiazide
  • hydrochlorzide
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
  • Molecular weight: 297.73
  • Formula: C7H8ClN3O4S2
  • CLOGP: -0.36
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -2.12
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O
25 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.60 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 100 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.18 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Feb. 12, 1959 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 2576.88 25.11 647 5409 12678 2339351
Hypokalaemia 1258.61 25.11 352 5704 10302 2341727
Completed suicide 1129.41 25.11 379 5677 20655 2331374
Acute kidney injury 901.10 25.11 346 5710 27776 2324253
Hypotension 877.47 25.11 353 5703 32083 2319946
Blood pressure increased 796.03 25.11 277 5779 16709 2335320
Dizziness 747.26 25.11 377 5679 58288 2293741
Fall 655.80 25.11 322 5734 46777 2305252
Drug hypersensitivity 640.71 25.11 316 5740 46327 2305702
Asthenia 518.97 25.11 275 5781 46651 2305378
Hypertension 512.19 25.11 230 5826 27131 2324898
Syncope 497.12 25.11 196 5860 16679 2335350
Dehydration 470.50 25.11 204 5852 22091 2329938
Drug interaction 424.11 25.11 206 5850 28957 2323072
Nausea 411.15 25.11 328 5728 111861 2240168
Toxicity to various agents 372.58 25.11 196 5860 32558 2319471
Vomiting 368.10 25.11 257 5799 71345 2280684
Blood pressure inadequately controlled 357.36 25.11 79 5977 821 2351208
Confusional state 344.67 25.11 169 5887 24175 2327854
Inappropriate antidiuretic hormone secretion 329.87 25.11 89 5967 2220 2349809
Headache 321.94 25.11 248 5808 79931 2272098
Malaise 319.50 25.11 214 5842 55371 2296658
Blood potassium decreased 312.16 25.11 103 5953 5202 2346827
Angioedema 298.40 25.11 112 5944 8284 2343745
Drug ineffective 274.42 25.11 250 5806 101374 2250655
Oedema peripheral 266.33 25.11 141 5915 23622 2328407
Hyperkalaemia 243.97 25.11 88 5968 5805 2346224
Hypercalcaemia 243.43 25.11 72 5984 2520 2349509
Blood creatinine increased 236.69 25.11 101 5955 10432 2341597
Orthostatic hypotension 235.97 25.11 72 5984 2807 2349222
Dyspnoea 232.48 25.11 204 5852 78529 2273500
Fatigue 225.13 25.11 207 5849 84666 2267363
Somnolence 220.49 25.11 124 5932 23361 2328668
Diarrhoea 218.09 25.11 202 5854 83362 2268667
Cough 205.39 25.11 134 5922 32983 2319046
Blood pressure decreased 199.01 25.11 86 5970 9150 2342879
Blood sodium decreased 197.63 25.11 64 5992 3036 2348993
Cardiac arrest 197.08 25.11 99 5957 14831 2337198
Disorientation 194.00 25.11 76 5980 6296 2345733
Lactic acidosis 192.48 25.11 72 5984 5258 2346771
General physical health deterioration 190.27 25.11 95 5961 14044 2337985
Diabetes mellitus 185.43 25.11 77 5979 7418 2344611
Feeling abnormal 175.07 25.11 107 5949 23474 2328555
Loss of consciousness 162.32 25.11 94 5962 18673 2333356
Product prescribing error 160.15 25.11 54 6002 2906 2349123
Sinus bradycardia 156.78 25.11 49 6007 2067 2349962
Renal failure 155.63 25.11 89 5967 17260 2334769
Electrocardiogram QT prolonged 152.84 25.11 68 5988 7746 2344283
Decreased appetite 152.83 25.11 106 5950 28785 2323244
Blood urea increased 149.73 25.11 54 6002 3551 2348478
Renal impairment 139.21 25.11 69 5987 10023 2342006
Abdominal pain 138.51 25.11 107 5949 34267 2317762
Hypochloraemia 137.83 25.11 30 6026 287 2351742
Blood glucose increased 129.16 25.11 70 5986 12220 2339809
Rash 128.52 25.11 130 5926 59428 2292601
Rhabdomyolysis 126.80 25.11 57 5999 6647 2345382
Hypovolaemia 119.83 25.11 35 6021 1168 2350861
Chest pain 118.58 25.11 90 5966 28047 2323982
Conjoined twins 117.11 25.11 18 6038 10 2352019
Hypomagnesaemia 116.26 25.11 41 6015 2523 2349506
Swollen tongue 115.80 25.11 50 6006 5293 2346736
Pancreatitis acute 113.84 25.11 45 6011 3808 2348221
Weight decreased 113.52 25.11 88 5968 28283 2323746
Blood pressure fluctuation 112.53 25.11 37 6019 1838 2350191
Tremor 111.96 25.11 77 5979 20584 2331445
Pruritus 111.00 25.11 104 5952 43236 2308793
Pemphigoid 108.63 25.11 31 6025 951 2351078
Pain 108.53 25.11 121 5935 61736 2290293
Gait disturbance 108.18 25.11 78 5978 22467 2329562
Torsade de pointes 105.98 25.11 37 6019 2209 2349820
Atrial fibrillation 105.95 25.11 64 5992 13704 2338325
Bradycardia 105.26 25.11 57 5999 9924 2342105
Cardio-respiratory arrest 104.23 25.11 55 6001 9091 2342938
Milk-alkali syndrome 103.84 25.11 20 6036 96 2351933
Dysarthria 98.63 25.11 47 6009 6255 2345774
Intentional overdose 98.55 25.11 57 5999 11264 2340765
Muscle spasms 97.53 25.11 72 5984 21494 2330535
Pain in extremity 97.41 25.11 96 5960 42444 2309585
Hypoglycaemia 97.06 25.11 51 6005 8356 2343673
Cerebrovascular accident 94.91 25.11 69 5987 20117 2331912
Lethargy 92.44 25.11 50 6006 8680 2343349
Peripheral swelling 91.58 25.11 64 5992 17533 2334496
Swelling 91.06 25.11 62 5994 16288 2335741
Drug intolerance 90.93 25.11 58 5998 13659 2338370
Hypertensive crisis 90.84 25.11 34 6022 2479 2349550
Pancreatitis 90.39 25.11 48 6008 8031 2343998
Blood pressure systolic increased 89.52 25.11 33 6023 2306 2349723
Vertigo 89.06 25.11 50 6006 9334 2342695
Depression 86.72 25.11 75 5981 28057 2323972
Urinary incontinence 86.46 25.11 38 6018 4195 2347834
Electrolyte imbalance 86.38 25.11 31 6025 2006 2350023
Constipation 86.26 25.11 67 5989 21562 2330467
Urachal abnormality 86.09 25.11 13 6043 5 2352024
Palpitations 85.98 25.11 60 5996 16396 2335633
Intestinal malrotation 85.29 25.11 15 6041 38 2351991
Ventricular fibrillation 84.04 25.11 31 6025 2170 2349859
Visual impairment 83.66 25.11 52 6004 11703 2340326
Persistent cloaca 82.90 25.11 13 6043 10 2352019
Hypersensitivity 81.13 25.11 67 5989 23526 2328503
Back pain 81.01 25.11 76 5980 31583 2320446
Abdominal pain upper 80.70 25.11 65 5991 22035 2329994
Congenital bladder anomaly 80.35 25.11 13 6043 15 2352014
Product substitution issue 79.90 25.11 38 6018 5031 2346998
Coma 79.87 25.11 46 6010 9010 2343019
Oligohydramnios 78.56 25.11 24 6032 936 2351093
Respiratory arrest 78.55 25.11 40 6016 6138 2345891
Myocardial infarction 78.21 25.11 60 5996 18953 2333076
Glaucoma 78.12 25.11 29 6027 2066 2349963
Suicide attempt 77.99 25.11 49 6007 11233 2340796
Product complaint 77.64 25.11 36 6020 4502 2347527
Blood potassium increased 76.79 25.11 29 6027 2167 2349862
Angina pectoris 75.67 25.11 34 6022 3953 2348076
Tachycardia 74.63 25.11 55 6001 16354 2335675
Anuria 74.49 25.11 27 6029 1797 2350232
Urinary tract infection 73.01 25.11 70 5986 29872 2322157
Cardiac failure 72.44 25.11 48 6008 12046 2339983
Left ventricular hypertrophy 72.19 25.11 21 6035 690 2351339
Weight increased 71.75 25.11 61 5995 22276 2329753
Muscular weakness 70.16 25.11 51 6005 14846 2337183
Swelling face 70.09 25.11 43 6013 9450 2342579
Oedema 69.73 25.11 44 6012 10159 2341870
Product administration error 69.70 25.11 32 6024 3911 2348118
International normalised ratio increased 69.36 25.11 39 6017 7297 2344732
Cutaneous T-cell lymphoma 68.22 25.11 17 6039 305 2351724
Depressed level of consciousness 68.05 25.11 39 6017 7565 2344464
Pyrexia 67.77 25.11 89 5967 53619 2298410
Deafness 67.57 25.11 28 6028 2673 2349356
Overdose 67.30 25.11 56 6000 19851 2332178
Blood pressure diastolic decreased 67.27 25.11 22 6034 1073 2350956
Memory impairment 67.20 25.11 47 6009 12876 2339153
Hypocalcaemia 67.03 25.11 31 6025 3852 2348177
Joint swelling 66.81 25.11 52 6004 16767 2335262
Limb malformation 66.54 25.11 14 6042 112 2351917
Vision blurred 66.32 25.11 49 6007 14619 2337410
Epileptic encephalopathy 65.76 25.11 11 6045 18 2352011
Balance disorder 64.03 25.11 41 6015 9706 2342323
Blood chloride decreased 63.56 25.11 19 6037 687 2351342
Hypoaesthesia 62.46 25.11 54 6002 20161 2331868
Heart rate increased 61.53 25.11 42 6014 11063 2340966
Metabolic alkalosis 61.51 25.11 16 6040 343 2351686
Bundle branch block left 61.38 25.11 20 6036 964 2351065
Foetal exposure during pregnancy 60.98 25.11 32 6024 5220 2346809
Hyperhidrosis 59.77 25.11 47 6009 15375 2336654
Arthralgia 59.45 25.11 84 5972 54201 2297828
Renal tubular necrosis 59.24 25.11 22 6034 1568 2350461
Seizure 59.24 25.11 57 5999 24409 2327620
Urticaria 57.76 25.11 56 6000 24205 2327824
Anxiety 57.54 25.11 61 5995 29298 2322731
Contusion 56.13 25.11 42 6014 12768 2339261
Nervousness 55.69 25.11 30 6026 5159 2346870
Anaemia 55.66 25.11 65 5991 34727 2317302
Electrocardiogram QRS complex prolonged 55.24 25.11 19 6037 1083 2350946
Breast cancer 55.19 25.11 37 6019 9458 2342571
Lip swelling 54.91 25.11 29 6027 4792 2347237
Non-cardiogenic pulmonary oedema 54.02 25.11 12 6044 127 2351902
Myalgia 53.93 25.11 53 6003 23280 2328749
Dysphagia 53.92 25.11 41 6015 12764 2339265
Gout 53.72 25.11 20 6036 1435 2350594
Sprue-like enteropathy 53.70 25.11 11 6045 76 2351953
Poisoning 53.35 25.11 24 6032 2796 2349233
Condition aggravated 53.25 25.11 61 5995 31918 2320111
Cholestasis 52.91 25.11 26 6030 3695 2348334
Delirium 52.73 25.11 29 6027 5194 2346835
Sinus tachycardia 52.61 25.11 25 6031 3300 2348729
Presyncope 52.37 25.11 26 6030 3777 2348252
Electrocardiogram abnormal 51.50 25.11 19 6037 1329 2350700
Leukocytosis 50.88 25.11 25 6031 3551 2348478
Blood pressure abnormal 50.64 25.11 20 6036 1685 2350344
Blood cholesterol increased 49.90 25.11 28 6028 5213 2346816
Death 49.86 25.11 97 5959 81371 2270658
Incorrect dose administered 49.78 25.11 35 6021 9660 2342369
Fluid retention 49.67 25.11 31 6025 7015 2345014
Wrong technique in product usage process 49.67 25.11 47 6009 19701 2332328
Product dispensing error 49.26 25.11 22 6034 2519 2349510
Interstitial lung disease 49.18 25.11 32 6024 7780 2344249
Arrhythmia 48.86 25.11 29 6027 5999 2346030
Drug reaction with eosinophilia and systemic symptoms 48.56 25.11 28 6028 5490 2346539
Acidosis 48.22 25.11 19 6037 1591 2350438
Dry mouth 47.58 25.11 32 6024 8221 2343808
Haemodialysis 46.90 25.11 20 6036 2049 2349980
Blood osmolarity decreased 46.55 25.11 11 6045 156 2351873
Metabolic acidosis 46.39 25.11 28 6028 5970 2346059
Orthostatic intolerance 46.36 25.11 11 6045 159 2351870
Insomnia 46.00 25.11 51 6005 25736 2326293
Cerebellar syndrome 45.30 25.11 14 6042 567 2351462
Cutaneous lupus erythematosus 44.48 25.11 14 6042 603 2351426
Heart rate decreased 44.39 25.11 23 6033 3653 2348376
Pollakiuria 43.93 25.11 23 6033 3733 2348296
Ataxia 43.33 25.11 20 6036 2472 2349557
Face oedema 42.85 25.11 23 6033 3925 2348104
Osteoarthritis 42.62 25.11 28 6028 6918 2345111
Shock 42.54 25.11 23 6033 3981 2348048
Gastrooesophageal reflux disease 42.48 25.11 31 6025 9064 2342965
Vitiligo 41.97 25.11 11 6045 243 2351786
Angle closure glaucoma 41.90 25.11 14 6042 730 2351299
Exposure during pregnancy 41.78 25.11 48 6008 25171 2326858
Loss of personal independence in daily activities 41.61 25.11 25 6031 5286 2346743
Ventricular extrasystoles 41.27 25.11 18 6038 1948 2350081
Chest discomfort 41.08 25.11 37 6019 14558 2337471
Abdominal discomfort 40.97 25.11 40 6016 17416 2334613
Small cell carcinoma 40.77 25.11 8 6048 43 2351986
Anaphylactic reaction 40.68 25.11 31 6025 9674 2342355
Hypophosphataemia 40.57 25.11 15 6041 1055 2350974
Dementia Alzheimer's type 40.14 25.11 14 6042 832 2351197
Haematoma 39.84 25.11 24 6032 5097 2346932
Hypophagia 39.80 25.11 22 6034 3978 2348051
Speech disorder 39.52 25.11 26 6030 6438 2345591
Serotonin syndrome 39.48 25.11 21 6035 3519 2348510
Blood uric acid increased 39.47 25.11 13 6043 648 2351381
Haematemesis 39.38 25.11 22 6034 4060 2347969
Glomerular filtration rate decreased 39.11 25.11 16 6040 1477 2350552
Pulmonary oedema 38.77 25.11 27 6029 7336 2344693
Product monitoring error 38.60 25.11 9 6047 120 2351909
Jaundice 38.23 25.11 24 6032 5484 2346545
Neck pain 37.69 25.11 27 6029 7670 2344359
Photosensitivity reaction 37.64 25.11 18 6038 2409 2349620
Hypertensive emergency 37.49 25.11 10 6046 237 2351792
Renal disorder 37.44 25.11 22 6034 4466 2347563
Osmotic demyelination syndrome 37.19 25.11 9 6047 142 2351887
Chills 37.17 25.11 36 6020 15516 2336513
Waist circumference increased 37.13 25.11 9 6047 143 2351886
Skin disorder 36.20 25.11 20 6036 3611 2348418
Mental status changes 35.46 25.11 23 6033 5559 2346470
Dysgeusia 35.41 25.11 27 6029 8432 2343597
Nephrogenic diabetes insipidus 35.00 25.11 9 6047 184 2351845
Hypothyroidism 34.96 25.11 21 6035 4436 2347593
Proteinuria 34.89 25.11 18 6038 2832 2349197
Mixed liver injury 34.68 25.11 10 6046 318 2351711
Tubulointerstitial nephritis 34.55 25.11 17 6039 2421 2349608
Labelled drug-drug interaction medication error 34.20 25.11 14 6042 1294 2350735
Eosinophilic bronchitis 34.17 25.11 6 6050 15 2352014
Reaction to excipient 33.54 25.11 10 6046 358 2351671
Nodal rhythm 33.17 25.11 10 6046 372 2351657
Body temperature increased 33.09 25.11 18 6038 3153 2348876
Agitation 33.05 25.11 29 6027 11022 2341007
Oropharyngeal swelling 32.87 25.11 9 6047 236 2351793
Hepatic steatosis 32.87 25.11 18 6038 3195 2348834
Hepatitis 32.81 25.11 23 6033 6314 2345715
Glycosylated haemoglobin increased 32.76 25.11 15 6041 1819 2350210
Stress cardiomyopathy 32.71 25.11 14 6042 1447 2350582
Disturbance in attention 32.66 25.11 22 6034 5663 2346366
Hyperthermia 32.64 25.11 14 6042 1454 2350575
Infarction 32.25 25.11 11 6045 611 2351418
Erythema 32.13 25.11 42 6014 25117 2326912
Choroidal effusion 31.97 25.11 8 6048 146 2351883
Cardiomegaly 31.86 25.11 16 6040 2380 2349649
Blood creatine increased 31.81 25.11 11 6045 637 2351392
Hypoacusis 31.79 25.11 18 6038 3407 2348622
Visual acuity reduced 31.63 25.11 21 6035 5277 2346752
Blister 31.44 25.11 23 6033 6748 2345281
Mitral valve incompetence 30.92 25.11 16 6040 2534 2349495
Gastroenteritis 30.90 25.11 17 6039 3043 2348986
Blindness 30.87 25.11 18 6038 3600 2348429
Treatment noncompliance 30.80 25.11 21 6035 5513 2346516
Alanine aminotransferase increased 30.78 25.11 31 6025 14001 2338028
C-reactive protein increased 30.76 25.11 22 6034 6233 2345796
Hyperglycaemia 30.71 25.11 20 6036 4865 2347164
Intentional product misuse 30.60 25.11 26 6030 9463 2342566
Drug-induced liver injury 30.50 25.11 18 6038 3681 2348348
Pneumonia 30.45 25.11 59 5997 49237 2302792
Hypotonia 30.43 25.11 14 6042 1716 2350313
Wheezing 30.35 25.11 22 6034 6362 2345667
Basal cell carcinoma 30.13 25.11 16 6040 2671 2349358
Blood creatine phosphokinase increased 29.80 25.11 20 6036 5116 2346913
Blood hyposmosis 29.59 25.11 5 6051 9 2352020
Paraesthesia oral 29.57 25.11 15 6041 2279 2349750
Gouty arthritis 29.51 25.11 7 6049 101 2351928
Hyponatraemic syndrome 29.51 25.11 7 6049 101 2351928
Arthritis 29.49 25.11 26 6030 9942 2342087
Diabetes mellitus inadequate control 29.27 25.11 14 6042 1873 2350156
Haemoglobin decreased 29.13 25.11 34 6022 18117 2333912
Electrocardiogram ST segment depression 29.03 25.11 10 6046 572 2351457
Psychomotor retardation 29.02 25.11 10 6046 573 2351456
Hypovitaminosis 28.72 25.11 7 6049 114 2351915
Polyuria 28.70 25.11 12 6044 1170 2350859
Electrocardiogram ST segment elevation 28.69 25.11 10 6046 593 2351436
Cardiac disorder 28.46 25.11 23 6033 7810 2344219
Paraesthesia 28.39 25.11 37 6019 22051 2329978
Cyanopsia 28.33 25.11 5 6051 13 2352016
Polydipsia 28.17 25.11 10 6046 626 2351403
Loss of employment 27.70 25.11 7 6049 133 2351896
Premature baby 27.49 25.11 16 6040 3188 2348841
Blood glucose decreased 27.27 25.11 16 6040 3236 2348793
Cataract 27.27 25.11 20 6036 5888 2346141
Therapeutic response unexpected 27.24 25.11 17 6039 3842 2348187
Colitis 27.13 25.11 19 6037 5207 2346822
Nephrolithiasis 27.10 25.11 18 6038 4525 2347504
End stage renal disease 27.07 25.11 9 6047 462 2351567
Obstructive airways disorder 26.97 25.11 12 6044 1361 2350668
Blood sodium increased 26.96 25.11 9 6047 468 2351561
Sjogren's syndrome 26.94 25.11 11 6045 1010 2351019
Supraventricular extrasystoles 26.74 25.11 10 6046 726 2351303
Asthma 26.67 25.11 26 6030 11288 2340741
Medication error 26.61 25.11 20 6036 6111 2345918
Liver injury 26.57 25.11 14 6042 2300 2349729
Caesarean section 26.37 25.11 17 6039 4064 2347965
Wound treatment 26.32 25.11 6 6050 72 2351957
Renal tubular disorder 26.14 25.11 9 6047 514 2351515
Aspartate aminotransferase increased 26.09 25.11 27 6029 12585 2339444
Thrombocytopenia 26.08 25.11 33 6023 19098 2332931
Dyspepsia 25.83 25.11 24 6032 9820 2342209
Urine output decreased 25.81 25.11 12 6044 1507 2350522
Respiratory rate increased 25.80 25.11 12 6044 1508 2350521
Stevens-Johnson syndrome 25.71 25.11 17 6039 4242 2347787
Heart rate abnormal 25.68 25.11 9 6047 542 2351487
Myoclonus 25.64 25.11 14 6042 2469 2349560
Hallucination 25.61 25.11 22 6034 8126 2343903
Dyspnoea exertional 25.58 25.11 19 6037 5701 2346328
Post-anoxic myoclonus 25.55 25.11 4 6052 3 2352026
Circulatory collapse 25.29 25.11 16 6040 3704 2348325
Dry skin 25.16 25.11 20 6036 6632 2345397

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1571.25 30.37 429 4485 8571 1733296
Acute kidney injury 1160.29 30.37 476 4438 34468 1707399
Hypotension 859.89 30.37 368 4546 29286 1712581
Completed suicide 809.76 30.37 299 4615 16013 1725854
Angioedema 752.07 30.37 248 4666 9416 1732451
Hypokalaemia 662.07 30.37 204 4710 6170 1735697
Syncope 594.09 30.37 230 4684 13939 1727928
Dizziness 470.94 30.37 256 4658 34105 1707762
Hypertension 331.12 30.37 168 4746 19280 1722587
Dehydration 325.46 30.37 161 4753 17497 1724370
Blood pressure increased 320.50 30.37 137 4777 10616 1731251
Hyperkalaemia 305.49 30.37 124 4790 8423 1733444
Fall 293.94 30.37 174 4740 27040 1714827
Toxicity to various agents 293.22 30.37 178 4736 28963 1712904
Blood creatinine increased 289.41 30.37 138 4776 13808 1728059
Blood pressure decreased 256.30 30.37 106 4808 7540 1734327
Blood urea increased 219.80 30.37 83 4831 4628 1737239
Milk-alkali syndrome 209.57 30.37 36 4878 47 1741820
Asthenia 204.15 30.37 152 4762 34518 1707349
Bradycardia 202.40 30.37 99 4815 10435 1731432
Renal failure 197.55 30.37 121 4793 19896 1721971
Drug interaction 178.93 30.37 129 4785 27829 1714038
Hypovolaemia 172.90 30.37 50 4864 1190 1740677
Pancreatitis acute 172.63 30.37 67 4847 4020 1737847
Inappropriate antidiuretic hormone secretion 172.56 30.37 54 4860 1694 1740173
Blood pressure inadequately controlled 172.26 30.37 43 4871 570 1741297
Hypomagnesaemia 162.87 30.37 54 4860 2044 1739823
Hypercalcaemia 156.28 30.37 51 4863 1835 1740032
Orthostatic hypotension 154.72 30.37 59 4855 3372 1738495
Nausea 152.54 30.37 152 4762 51044 1690823
Shock 150.53 30.37 61 4853 4100 1737767
Loss of consciousness 146.77 30.37 90 4824 14785 1727082
Pancreatitis 142.28 30.37 69 4845 7118 1734749
Dyspnoea 141.28 30.37 147 4767 51912 1689955
Drug hypersensitivity 137.75 30.37 87 4827 15048 1726819
Lactic acidosis 131.79 30.37 59 4855 5070 1736797
Intentional overdose 129.22 30.37 66 4848 7604 1734263
Confusional state 128.69 30.37 95 4819 21183 1720684
Vomiting 118.02 30.37 116 4798 38199 1703668
Drug ineffective 116.82 30.37 147 4767 63654 1678213
Hyperhidrosis 111.60 30.37 71 4843 12417 1729450
Fatigue 110.84 30.37 128 4786 50653 1691214
Malaise 105.19 30.37 97 4817 29468 1712399
Overdose 104.13 30.37 76 4838 16625 1725242
Blood sodium decreased 101.60 30.37 39 4875 2265 1739602
Rash 100.66 30.37 107 4807 38586 1703281
Actinic keratosis 97.00 30.37 27 4887 556 1741311
Suicide attempt 91.97 30.37 52 4862 7329 1734538
Metabolic acidosis 89.52 30.37 46 4868 5356 1736511
Metabolic alkalosis 89.22 30.37 21 4893 213 1741654
Oedema peripheral 88.48 30.37 67 4847 15483 1726384
Basal cell carcinoma 88.36 30.37 36 4878 2447 1739420
Blood potassium decreased 84.16 30.37 34 4880 2261 1739606
Renal impairment 83.49 30.37 59 4855 12255 1729612
Pruritus 82.14 30.37 76 4838 23146 1718721
Blood glucose increased 81.86 30.37 55 4859 10529 1731338
Swollen tongue 80.80 30.37 35 4879 2773 1739094
Hypochloraemia 80.19 30.37 18 4896 145 1741722
Hypophagia 79.61 30.37 37 4877 3460 1738407
Polyuria 79.28 30.37 28 4886 1282 1740585
Blood chloride decreased 78.90 30.37 23 4891 562 1741305
Chest pain 77.92 30.37 69 4845 19845 1722022
Electrocardiogram QRS complex prolonged 76.68 30.37 24 4890 751 1741116
Pulmonary oedema 75.61 30.37 44 4870 6542 1735325
Photosensitivity reaction 74.92 30.37 29 4885 1721 1740146
Diabetes mellitus 73.67 30.37 44 4870 6864 1735003
Tachycardia 73.11 30.37 55 4859 12573 1729294
Diarrhoea 72.37 30.37 107 4807 53745 1688122
Mental status changes 70.83 30.37 41 4873 6034 1735833
Polydipsia 69.52 30.37 22 4892 714 1741153
Headache 67.09 30.37 82 4832 34294 1707573
Cardiogenic shock 65.45 30.37 29 4885 2425 1739442
Pallor 65.17 30.37 32 4882 3379 1738488
Cardio-respiratory arrest 64.06 30.37 45 4869 9248 1732619
Palpitations 63.94 30.37 40 4874 6774 1735093
Extrasystoles 63.65 30.37 21 4893 780 1741087
Cardiac arrest 61.89 30.37 55 4859 15875 1725992
Respiratory arrest 61.75 30.37 37 4877 5802 1736065
Muscle spasms 61.51 30.37 48 4866 11573 1730294
Presyncope 59.71 30.37 28 4886 2670 1739197
Lichen planus 57.78 30.37 15 4899 234 1741633
Gout 57.43 30.37 27 4887 2589 1739278
Weight decreased 57.37 30.37 62 4852 22691 1719176
Cholestasis 57.22 30.37 30 4884 3635 1738232
Swelling face 56.93 30.37 32 4882 4451 1737416
Squamous cell carcinoma 56.04 30.37 24 4890 1847 1740020
Cough 54.98 30.37 56 4858 19141 1722726
Electrolyte imbalance 54.49 30.37 22 4892 1459 1740408
Petit mal epilepsy 53.73 30.37 17 4897 551 1741316
Hypophosphataemia 53.59 30.37 21 4893 1287 1740580
Oedema 53.43 30.37 36 4878 6912 1734955
Hypocalcaemia 52.62 30.37 27 4887 3129 1738738
Staring 51.66 30.37 15 4899 361 1741506
Muscular weakness 51.36 30.37 41 4873 10208 1731659
Incontinence 51.12 30.37 19 4895 1007 1740860
Cardiomegaly 50.96 30.37 24 4890 2310 1739557
Choroidal effusion 50.86 30.37 11 4903 73 1741794
Head injury 50.79 30.37 26 4888 2998 1738869
Blood lactic acid increased 49.80 30.37 18 4896 881 1740986
Skin cancer 49.07 30.37 20 4894 1359 1740508
Tubulointerstitial nephritis 48.43 30.37 25 4889 2933 1738934
Electrocardiogram QT prolonged 48.14 30.37 31 4883 5514 1736353
Gait disturbance 47.71 30.37 43 4871 12627 1729240
Supraventricular extrasystoles 47.45 30.37 16 4898 636 1741231
Left ventricular hypertrophy 46.97 30.37 17 4897 835 1741032
Atrial fibrillation 46.78 30.37 46 4868 15065 1726802
Rhabdomyolysis 46.48 30.37 40 4874 11050 1730817
Glycosylated haemoglobin increased 46.13 30.37 21 4893 1870 1739997
Pseudolymphoma 45.83 30.37 11 4903 122 1741745
Microalbuminuria 45.43 30.37 11 4903 127 1741740
Blood pressure diastolic decreased 45.25 30.37 16 4898 734 1741133
Blood pressure systolic increased 44.98 30.37 20 4894 1685 1740182
Paraesthesia 44.41 30.37 38 4876 10413 1731454
Vertigo 44.16 30.37 27 4887 4386 1737481
Lip swelling 43.97 30.37 23 4891 2772 1739095
Renal tubular necrosis 43.84 30.37 21 4893 2098 1739769
Hypertensive crisis 43.80 30.37 19 4895 1508 1740359
Myalgia 43.58 30.37 45 4869 15613 1726254
Discomfort 42.35 30.37 22 4892 2614 1739253
Hypovolaemic shock 42.27 30.37 16 4898 892 1740975
Choroidal detachment 42.25 30.37 10 4904 104 1741763
Dissociation 42.09 30.37 12 4902 270 1741597
Pemphigoid 42.06 30.37 17 4897 1130 1740737
Eczema 42.00 30.37 21 4893 2303 1739564
Nodular rash 41.90 30.37 8 4906 25 1741842
Product prescribing error 41.28 30.37 21 4893 2389 1739478
Abdominal pain 39.81 30.37 50 4864 21440 1720427
Precancerous skin lesion 39.52 30.37 10 4904 140 1741727
Water intoxication 39.52 30.37 10 4904 140 1741727
Circulatory collapse 39.33 30.37 23 4891 3444 1738423
Patent ductus arteriosus 39.13 30.37 14 4900 665 1741202
Respiratory failure 39.13 30.37 41 4873 14464 1727403
Nephrolithiasis 38.86 30.37 24 4890 3968 1737899
Diabetic neuropathy 38.86 30.37 13 4901 504 1741363
Retinal detachment 38.56 30.37 16 4898 1137 1740730
Angina pectoris 38.56 30.37 26 4888 4992 1736875
Heart rate decreased 38.25 30.37 21 4893 2788 1739079
Oliguria 37.97 30.37 16 4898 1182 1740685
Weight increased 37.82 30.37 36 4878 11321 1730546
Premature baby 37.34 30.37 21 4893 2921 1738946
Decreased appetite 37.18 30.37 51 4863 23820 1718047
Blood uric acid increased 37.15 30.37 15 4899 994 1740873
Cerebrovascular accident 37.02 30.37 44 4870 17822 1724045
Daydreaming 37.00 30.37 9 4905 106 1741761
Anuria 36.91 30.37 18 4896 1870 1739997
Bowen's disease 36.33 30.37 11 4903 307 1741560
Erythema 36.31 30.37 39 4875 14149 1727718
Troponin I increased 36.23 30.37 11 4903 310 1741557
Muscle necrosis 36.18 30.37 10 4904 200 1741667
Weaning failure 35.90 30.37 8 4906 62 1741805
Cutaneous T-cell lymphoma 35.54 30.37 11 4903 331 1741536
Haemoglobin decreased 35.21 30.37 42 4872 17072 1724795
Blood potassium increased 34.68 30.37 19 4895 2511 1739356
Hypoglycaemia 34.46 30.37 30 4884 8408 1733459
Spinal cord infarction 34.36 30.37 8 4906 77 1741790
Multiple organ dysfunction syndrome 34.05 30.37 31 4883 9211 1732656
Blood creatine increased 33.90 30.37 13 4901 751 1741116
Seizure 33.84 30.37 45 4869 20396 1721471
Erectile dysfunction 33.84 30.37 23 4891 4474 1737393
Urticaria 33.72 30.37 35 4879 12206 1729661
Acute respiratory distress syndrome 33.68 30.37 21 4893 3530 1738337
Visual impairment 33.56 30.37 26 4888 6192 1735675
Hyperglycaemia 33.23 30.37 24 4890 5141 1736726
Ventricular fibrillation 33.16 30.37 19 4895 2737 1739130
Anaemia 33.08 30.37 54 4860 29403 1712464
Foetal exposure during pregnancy 33.04 30.37 26 4888 6333 1735534
Bundle branch block left 32.90 30.37 13 4901 814 1741053
Febrile neutropenia 32.87 30.37 33 4881 11067 1730800
Somnolence 32.67 30.37 40 4874 16699 1725168
Pain in extremity 32.65 30.37 42 4872 18430 1723437
Condition aggravated 32.64 30.37 45 4869 21105 1720762
Interstitial granulomatous dermatitis 32.42 30.37 7 4907 46 1741821
Hypoaesthesia 32.40 30.37 31 4883 9804 1732063
Product complaint 32.21 30.37 18 4896 2472 1739395
Drug eruption 32.11 30.37 19 4895 2907 1738960
Poisoning 31.93 30.37 18 4896 2514 1739353
Glomerular filtration rate decreased 31.85 30.37 15 4899 1442 1740425
Cardiac disorder 30.71 30.37 27 4887 7664 1734203
Heat stroke 30.66 30.37 9 4905 225 1741642
Heart rate increased 30.39 30.37 25 4889 6485 1735382
Drug level increased 30.39 30.37 18 4896 2759 1739108

Pharmacologic Action:

SourceCodeDescription
ATC C03AA03 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, plain
ATC C03AB03 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides and potassium in combination
ATC C03AX01 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, combinations with other drugs
ATC C03EA01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Low-ceiling diuretics and potassium-sparing agents
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09DX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09XA52 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C09XA54 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
FDA PE N0000175359 Increased Diuresis
FDA EPC N0000175419 Thiazide Diuretic
FDA CS M0471776 Thiazides
CHEBI has role CHEBI:35498 diuretic
CHEBI has role CHEBI:35674 antihypertensive agent
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049993 Sodium Chloride Symporter Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Edema indication 267038008
Hypertensive urgency indication 443482000
Pulmonary Edema due to Chronic Heart Failure indication
Peripheral Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Hypertension with Left Ventricular Hypertrophy indication
Edema due to Nephrotic Syndrome indication
Nephrogenic diabetes insipidus off-label use 111395007 DOID:12387
Calcium renal calculus off-label use 427649000
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Suicidal thoughts contraindication 6471006
Psoriasis contraindication 9014002 DOID:8893
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Chronic disease of respiratory system contraindication 17097001
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Jaundice contraindication 18165001
Cirrhosis of liver contraindication 19943007 DOID:5082
Secondary angle-closure glaucoma contraindication 21571006
Electroconvulsive therapy contraindication 23835007
Acute vomiting contraindication 23971007
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Obstruction of bile duct contraindication 30144000
Parkinsonism contraindication 32798002
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Acute hepatitis contraindication 37871000
Immunosuppression contraindication 38013005
Anaphylaxis contraindication 39579001
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Sinus bradycardia contraindication 49710005
Cough contraindication 49727002
Acidosis contraindication 51387008
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Aortic valve stenosis contraindication 60573004 DOID:1712
Chronic bronchitis contraindication 63480004 DOID:6132
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Benign intracranial hypertension contraindication 68267002 DOID:11459
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Oliguria contraindication 83128009
Epilepsy contraindication 84757009 DOID:1826
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Kidney stone contraindication 95570007
Disorder of connective tissue contraindication 105969002 DOID:65
Diabetic renal disease contraindication 127013003
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Asthma contraindication 195967001 DOID:2841
Acute hepatic failure contraindication 197270009
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Disorder of electrolytes contraindication 237840007
Lupus erythematosus and erythema multiforme-like syndrome contraindication 238926009
Rhabdomyolysis contraindication 240131006
Raynaud's phenomenon contraindication 266261006
Calculus in biliary tract contraindication 266474003
Anemia contraindication 271737000 DOID:2355
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Pheochromocytoma contraindication 302835009
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Severe chronic obstructive pulmonary disease contraindication 313299006
Right ventricular failure contraindication 367363000
Surgical procedure contraindication 387713003
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Severe diarrhea contraindication 409587002
Autoimmune hemolytic anemia contraindication 413603009 DOID:718
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Porphyria contraindication 418470004
Intraoperative floppy iris syndrome contraindication 418801006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Severe Cerebrovascular Disease contraindication
Severe Aortic Valve Stenosis contraindication
Head and Neck Angioedema contraindication
Hemodialysis with High-Flux Membrane contraindication
First Degree Atrioventricular Heart Block contraindication
Intestinal Angioedema contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.89 acidic
pKa2 11.02 acidic
pKa3 0.71 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 3 Transporter INHIBITOR A2 7.01 WOMBAT-PK CHEMBL
Carbonic anhydrase 1 Enzyme Ki 6.48 CHEMBL
Calcium-activated potassium channel subunit alpha-1 Ion channel WOMBAT-PK
Carbonic anhydrase 4 Enzyme WOMBAT-PK
Carbonic anhydrase 2 Enzyme Ki 5.90 WOMBAT-PK
Delta carbonic anhydrase Unclassified Ki 5.37 CHEMBL
Astrosclerin-3 Unclassified Ki 6.40 CHEMBL
Carbonic anhydrase Unclassified Ki 7.50 CHEMBL

External reference:

IDSource
D006852 MESH_DESCRIPTOR_UI
4017615 VUID
N0000145995 NUI
C0020261 UMLSCUI
D00340 KEGG_DRUG
0J48LPH2TH UNII
841 INN_ID
91667005 SNOMEDCT_US
5487 RXNORM
387525002 SNOMEDCT_US
4834 MMSL
4017615 VANDF
002294 NDDF
d00253 MMSL
924 MMSL
CHEBI:5778 CHEBI
CHEMBL435 ChEMBL_ID
CHEMBL15605 ChEMBL_ID
CHEMBL43686 ChEMBL_ID
DB00999 DRUGBANK_ID
3639 PUBCHEM_CID
4836 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
HYZAAR HUMAN PRESCRIPTION DRUG LABEL 2 0006-0717 TABLET, FILM COATED 12.50 mg ORAL NDA 19 sections
HYZAAR HUMAN PRESCRIPTION DRUG LABEL 2 0006-0745 TABLET, FILM COATED 12.50 mg ORAL NDA 19 sections
HYZAAR HUMAN PRESCRIPTION DRUG LABEL 2 0006-0747 TABLET, FILM COATED 25 mg ORAL NDA 19 sections
DYAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0007-3650 CAPSULE 25 mg ORAL NDA 12 sections
Microzide HUMAN PRESCRIPTION DRUG LABEL 1 0023-6154 CAPSULE, GELATIN COATED 12.50 mg ORAL NDA 11 sections
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5855 TABLET, FILM COATED 12.50 mg ORAL NDA 18 sections
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5856 TABLET, FILM COATED 12.50 mg ORAL NDA 18 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1011 TABLET, FILM COATED 25 mg ORAL NDA 12 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1021 TABLET, FILM COATED 50 mg ORAL NDA 12 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0254 TABLET 12.50 mg ORAL ANDA 17 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0255 TABLET 12.50 mg ORAL ANDA 17 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0545 TABLET 12.50 mg ORAL NDA authorized generic 18 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0546 TABLET 12.50 mg ORAL NDA authorized generic 18 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0547 TABLET 25 mg ORAL NDA authorized generic 18 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 1 0071-0220 TABLET, FILM COATED 12.50 mg ORAL NDA 13 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 1 0071-0222 TABLET, FILM COATED 12.50 mg ORAL NDA 13 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 1 0071-0223 TABLET, FILM COATED 25 mg ORAL NDA 13 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0314 TABLET, FILM COATED 12.50 mg ORAL NDA 18 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0315 TABLET, FILM COATED 12.50 mg ORAL NDA 18 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0383 TABLET, FILM COATED 25 mg ORAL NDA 18 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0471 TABLET, FILM COATED 12.50 mg ORAL NDA 18 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0472 TABLET, FILM COATED 25 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0559 TABLET, FILM COATED 12.50 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0560 TABLET, FILM COATED 25 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0561 TABLET, FILM COATED 12.50 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0562 TABLET, FILM COATED 25 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0563 TABLET, FILM COATED 25 mg ORAL NDA 18 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3241 TABLET, FILM COATED 6.25 mg ORAL NDA AUTHORIZED GENERIC 14 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3242 TABLET, FILM COATED 6.25 mg ORAL NDA AUTHORIZED GENERIC 14 sections
bisoprolol fumarate and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0093-3243 TABLET, FILM COATED 6.25 mg ORAL NDA AUTHORIZED GENERIC 14 sections