hydrochlorothiazide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 1385 58-93-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrochlorothiazide
  • hydrochlorothiazid
  • hydrochlorthiazide
  • hydrochlorzide
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
  • Molecular weight: 297.73
  • Formula: C7H8ClN3O4S2
  • CLOGP: -0.36
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -2.12
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O
25 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.72 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 100 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.18 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.56 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Feb. 12, 1959 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1225.56 9.85 1786 236089 110114 63141033
Pemphigus 616.93 9.85 15 237860 183711 63067436
Maternal exposure during pregnancy 538.52 9.85 89 237786 219973 63031174
Hypokalaemia 529.96 9.85 1189 236686 102615 63148532
Hand deformity 487.51 9.85 27 237848 159430 63091717
Systemic lupus erythematosus 469.81 9.85 104 237771 208814 63042333
Glossodynia 445.09 9.85 69 237806 178807 63072340
Contraindicated product administered 345.16 9.85 193 237682 217455 63033692
Synovitis 322.93 9.85 148 237727 186770 63064377
Off label use 321.10 9.85 1370 236505 673092 62578055
Acute kidney injury 312.39 9.85 1868 236007 261547 62989600
Duodenal ulcer perforation 301.07 9.85 5 237870 87204 63163943
Blood pressure increased 298.62 9.85 1301 236574 160761 63090386
Pericarditis 279.02 9.85 74 237801 131505 63119642
Treatment failure 276.64 9.85 205 237670 198838 63052309
Exposure during pregnancy 273.60 9.85 120 237755 155427 63095720
Wound 271.69 9.85 136 237739 163127 63088020
Drug intolerance 265.18 9.85 469 237406 308192 62942955
Alopecia 243.03 9.85 568 237307 336968 62914179
Myocardial infarction 240.34 9.85 872 237003 99021 63152126
Blood potassium decreased 237.75 9.85 502 237373 41524 63209623
Arthropathy 228.75 9.85 328 237547 234464 63016683
Drug ineffective 226.22 9.85 2670 235205 1042095 62209052
Cerebrovascular accident 222.10 9.85 897 236978 107127 63144020
Discomfort 217.90 9.85 184 237691 167190 63083957
Lower respiratory tract infection 208.65 9.85 118 237757 132189 63118958
Angioedema 206.10 9.85 514 237361 47451 63203696
Rheumatoid factor positive 189.61 9.85 42 237833 84364 63166783
Dehydration 178.24 9.85 1186 236689 172168 63078979
Muscle injury 177.37 9.85 19 237856 65326 63185821
Folliculitis 175.07 9.85 27 237848 70290 63180857
Helicobacter infection 173.82 9.85 65 237810 92720 63158427
Macular degeneration 162.73 9.85 312 237563 24064 63227083
Sleep disorder due to general medical condition, insomnia type 162.14 9.85 8 237867 52209 63198938
Abdominal discomfort 161.96 9.85 636 237239 320249 62930898
Product use issue 161.85 9.85 367 237508 220153 63030994
Dizziness 159.56 9.85 2376 235499 427549 62823598
Coronary artery disease 157.40 9.85 364 237511 32013 63219134
Syncope 151.55 9.85 852 237023 116533 63134614
Infusion related reaction 150.04 9.85 448 237427 245073 63006074
Swelling 149.91 9.85 529 237346 274849 62976298
Blood pressure inadequately controlled 144.99 9.85 132 237743 4846 63246301
Eosinophilic bronchitis 141.97 9.85 60 237815 513 63250634
Therapeutic product effect decreased 141.34 9.85 322 237553 192865 63058282
Joint swelling 138.41 9.85 694 237181 326972 62924175
Inappropriate antidiuretic hormone secretion 135.57 9.85 223 237652 15239 63235908
Condition aggravated 131.73 9.85 924 236951 401293 62849854
Blister 130.66 9.85 177 237698 129637 63121510
Infection 129.59 9.85 433 237442 228740 63022407
Irritable bowel syndrome 127.76 9.85 75 237800 82337 63168810
Lactic acidosis 124.14 9.85 370 237505 37917 63213230
Transient ischaemic attack 121.61 9.85 364 237511 37389 63213758
Hepatic enzyme increased 119.43 9.85 375 237500 201953 63049194
Fall 116.30 9.85 2090 235785 390244 62860903
Hypotension 113.91 9.85 1539 236336 271065 62980082
Blood glucose increased 111.45 9.85 613 237262 83143 63168004
Asthenia 108.96 9.85 2030 235845 381574 62869573
Gastrooesophageal reflux disease 107.21 9.85 669 237206 94970 63156177
Drug abuse 106.85 9.85 70 237805 72448 63178699
Impaired healing 104.00 9.85 139 237736 102403 63148744
Abortion spontaneous 99.13 9.85 27 237848 47168 63203979
Product use in unapproved indication 93.41 9.85 350 237525 178730 63072417
Blood sodium decreased 90.92 9.85 247 237628 24005 63227142
Sprue-like enteropathy 88.63 9.85 47 237828 696 63250451
Mobility decreased 84.53 9.85 207 237668 120952 63130195
Death 84.50 9.85 946 236929 373435 62877712
Palpitations 83.83 9.85 715 237160 112055 63139092
Intentional product use issue 82.71 9.85 227 237648 127665 63123482
Hypertension 80.91 9.85 1483 236392 277820 62973327
Renal failure 80.75 9.85 733 237142 116919 63134228
Hip arthroplasty 80.23 9.85 39 237836 47607 63203540
Chest pain 79.64 9.85 1193 236682 214766 63036381
Live birth 79.33 9.85 4 237871 25626 63225521
Lung diffusion test abnormal 78.66 9.85 34 237841 309 63250838
Cardiac failure congestive 77.86 9.85 603 237272 91830 63159317
Hypertensive crisis 77.77 9.85 175 237700 15111 63236036
Oedema peripheral 77.47 9.85 1066 236809 188445 63062702
Hypersensitivity 76.97 9.85 713 237162 291972 62959175
Stomatitis 76.38 9.85 265 237610 138460 63112687
C-reactive protein abnormal 74.24 9.85 40 237835 46056 63205091
Hypochloraemia 74.17 9.85 61 237814 1948 63249199
Pain 73.86 9.85 2163 235712 738465 62512682
Pregnancy 73.83 9.85 23 237852 36813 63214334
Ill-defined disorder 73.00 9.85 121 237754 81634 63169513
Rash 71.98 9.85 1578 236297 559293 62691854
Therapy non-responder 71.88 9.85 108 237767 75793 63175354
Angina pectoris 70.94 9.85 261 237614 29817 63221330
Blood urea increased 70.92 9.85 239 237636 26140 63225007
Intentional self-injury 70.91 9.85 7 237868 25680 63225467
Pancreatitis acute 69.42 9.85 242 237633 26924 63224223
Liver injury 65.56 9.85 78 237797 60442 63190705
Cardiospasm 64.40 9.85 55 237820 1852 63249295
Psoriatic arthropathy 64.11 9.85 156 237719 91364 63159783
Polyp 63.97 9.85 99 237776 6422 63244725
Drug interaction 63.68 9.85 1209 236666 227922 63023225
Atrial tachycardia 63.61 9.85 79 237796 4161 63246986
Hypovolaemia 63.27 9.85 130 237745 10543 63240604
Palmoplantar keratoderma 61.96 9.85 55 237820 1952 63249195
Blood pressure diastolic decreased 61.28 9.85 206 237669 22500 63228647
Loss of employment 60.51 9.85 57 237818 2187 63248960
Gastrointestinal disorder 59.36 9.85 271 237604 130968 63120179
Product complaint 57.90 9.85 140 237735 12669 63238478
Myelosuppression 56.98 9.85 10 237865 23693 63227454
Hypertensive emergency 56.97 9.85 51 237824 1831 63249316
Hyperkalaemia 56.91 9.85 373 237502 53830 63197317
Blood creatinine increased 56.59 9.85 540 237335 87304 63163843
Hypoglycaemia 56.33 9.85 402 237473 59663 63191484
Nausea 55.81 9.85 3813 234062 850658 62400489
Red blood cell sedimentation rate abnormal 55.65 9.85 5 237870 19777 63231370
Febrile neutropenia 55.13 9.85 242 237633 118207 63132940
Carotid artery occlusion 54.30 9.85 77 237798 4617 63246530
Atrial fibrillation 54.29 9.85 672 237203 115964 63135183
Pruritus genital 54.23 9.85 58 237817 2596 63248551
Blood pressure systolic increased 52.12 9.85 330 237545 47067 63204080
Neutropenia 51.45 9.85 414 237461 174591 63076556
Sinus bradycardia 51.37 9.85 145 237730 14406 63236741
Disease progression 51.15 9.85 261 237614 122497 63128650
Sleep terror 50.29 9.85 56 237819 2624 63248523
Cytomegalovirus infection 50.02 9.85 9 237866 20943 63230204
Disorientation 49.31 9.85 284 237591 39168 63211979
Angina unstable 48.81 9.85 92 237783 7003 63244144
Toxicity to various agents 48.76 9.85 643 237232 246607 63004540
Diabetes mellitus 47.48 9.85 365 237510 55445 63195702
Malignant neoplasm progression 47.15 9.85 154 237721 81967 63169180
Arterial occlusive disease 47.02 9.85 82 237793 5876 63245271
Recalled product 46.44 9.85 40 237835 1363 63249784
Drug resistance 44.75 9.85 15 237860 22918 63228229
Cataract 44.64 9.85 366 237509 56687 63194460
Feeling abnormal 44.33 9.85 792 237083 147600 63103547
Musculoskeletal stiffness 44.17 9.85 460 237415 184158 63066989
Hypercalcaemia 42.96 9.85 215 237660 28107 63223040
Anosmia 42.38 9.85 85 237790 6775 63244372
Premature delivery 42.25 9.85 31 237844 30250 63220897
Tension headache 41.74 9.85 72 237803 5114 63246033
Neutrophil count decreased 40.41 9.85 95 237780 56311 63194836
Hepatic function abnormal 40.09 9.85 48 237827 37094 63214053
Fibromyalgia 40.08 9.85 160 237715 80260 63170887
Facial pain 40.02 9.85 108 237767 10453 63240694
Immunisation 39.46 9.85 34 237841 1159 63249988
Milk-alkali syndrome 38.92 9.85 29 237846 799 63250348
Large intestine polyp 38.86 9.85 91 237784 8066 63243081
Pneumonia aspiration 38.29 9.85 241 237634 34299 63216848
Intentional overdose 37.93 9.85 146 237729 74006 63177141
Hyperlipidaemia 37.41 9.85 159 237716 19412 63231735
Neutrophilia 36.56 9.85 62 237813 4344 63246803
Hospitalisation 36.52 9.85 179 237696 84902 63166245
Pancreatitis 36.41 9.85 311 237564 48744 63202403
Peripheral swelling 36.39 9.85 740 237135 265202 62985945
Ventricular hypertrophy 36.30 9.85 54 237821 3382 63247765
Nasopharyngitis 35.84 9.85 704 237171 253553 62997594
Subarachnoid haemorrhage 35.42 9.85 126 237749 14157 63236990
Rheumatoid arthritis 35.11 9.85 705 237170 253114 62998033
Prescribed overdose 34.91 9.85 46 237829 34107 63217040
Obstructive airways disorder 34.90 9.85 162 237713 20537 63230610
Allergic oedema 34.52 9.85 27 237848 801 63250346
Hyperhidrosis 34.52 9.85 582 237293 107254 63143893
Pyrexia 34.46 9.85 1427 236448 469051 62782096
Conjoined twins 34.21 9.85 18 237857 262 63250885
Pemphigoid 33.98 9.85 81 237794 7263 63243884
Heart rate irregular 33.86 9.85 170 237705 22251 63228896
Gastric disorder 33.82 9.85 248 237627 37121 63214026
Hepatic steatosis 33.31 9.85 203 237672 28566 63222581
Weight decreased 33.04 9.85 1309 236566 275489 62975658
Sedation complication 32.86 9.85 6 237869 13816 63237331
Bradycardia 32.40 9.85 418 237457 72809 63178338
Cough 32.33 9.85 1373 236502 291370 62959777
Blood chloride decreased 32.26 9.85 67 237808 5475 63245672
Rhabdomyolysis 31.76 9.85 277 237598 43674 63207473
Arrhythmia 31.64 9.85 248 237627 37892 63213255
Mitral valve incompetence 31.32 9.85 151 237724 19443 63231704
Adverse drug reaction 31.24 9.85 173 237702 79541 63171606
Intestinal angioedema 30.92 9.85 23 237852 632 63250515
Device expulsion 30.87 9.85 52 237823 34870 63216277
Leukopenia 30.69 9.85 167 237708 77123 63174024
Swollen tongue 30.39 9.85 229 237646 34571 63216576
Product monitoring error 30.38 9.85 58 237817 4458 63246689
Pneumonia 29.82 9.85 1403 236472 455364 62795783
Knee arthroplasty 29.51 9.85 104 237771 54102 63197045
Atrioventricular block first degree 29.21 9.85 76 237799 7197 63243950
Acute myeloid leukaemia 28.92 9.85 14 237861 17133 63234014
Mental status changes 28.83 9.85 250 237625 39349 63211798
Arteriosclerosis 28.66 9.85 93 237782 9973 63241174
Myalgia 28.53 9.85 735 237140 145794 63105353
Anxiety 28.14 9.85 1038 236837 216503 63034644
Electrolyte imbalance 28.08 9.85 149 237726 19927 63231220
Device related thrombosis 27.98 9.85 34 237841 1751 63249396
Foetal death 27.82 9.85 4 237871 10976 63240171
Muscle spasms 27.75 9.85 774 237101 155376 63095771
Blood creatine phosphokinase increased 27.57 9.85 202 237673 30228 63220919
Electrocardiogram abnormal 27.22 9.85 86 237789 9093 63242054
Essential hypertension 27.16 9.85 59 237816 4974 63246173
Joint range of motion decreased 27.12 9.85 50 237825 32378 63218769
Product prescribing error 27.04 9.85 180 237695 26109 63225038
Rotator cuff syndrome 26.82 9.85 111 237764 13391 63237756
Suicide attempt 26.81 9.85 127 237748 60791 63190356
Gangrene 26.69 9.85 66 237809 6057 63245090
Haemophagocytic lymphohistiocytosis 26.63 9.85 4 237871 10623 63240524
Bone marrow failure 26.46 9.85 43 237832 29247 63221900
Poisoning deliberate 26.39 9.85 5 237870 11213 63239934
Ventricular extrasystoles 26.38 9.85 100 237775 11587 63239560
Supraventricular extrasystoles 26.15 9.85 55 237820 4534 63246613
Product substitution issue 26.10 9.85 124 237751 15872 63235275
Carotid artery stenosis 26.09 9.85 59 237816 5111 63246036
Congenital bladder anomaly 25.87 9.85 13 237862 171 63250976
Respiratory tract inflammation 25.84 9.85 20 237855 584 63250563
Erythrodermic psoriasis 25.82 9.85 25 237850 993 63250154
Depression 25.52 9.85 938 236937 195554 63055593
Withdrawal hypertension 25.45 9.85 12 237863 136 63251011
Coma 25.43 9.85 360 237515 64004 63187143
Urachal abnormality 25.35 9.85 13 237862 179 63250968
Sepsis 25.02 9.85 413 237462 152710 63098437
Persistent cloaca 24.54 9.85 13 237862 192 63250955
Non-cardiogenic pulmonary oedema 24.52 9.85 21 237854 710 63250437
Systemic infection 24.43 9.85 54 237821 4606 63246541
Foetal exposure during pregnancy 24.39 9.85 52 237823 31910 63219237
Chronic sinusitis 24.28 9.85 104 237771 12739 63238408
Sinusitis 24.20 9.85 655 237220 225998 63025149
Cardiac disorder 24.16 9.85 294 237581 50522 63200625
Emotional distress 23.96 9.85 206 237669 32343 63218804
Insomnia 23.84 9.85 1010 236865 214242 63036905
Nervousness 23.83 9.85 198 237677 30781 63220366
Abnormal dreams 23.75 9.85 90 237785 10426 63240721
Breast cancer stage III 23.66 9.85 5 237870 10381 63240766
Platelet count decreased 23.59 9.85 300 237575 115822 63135325
C-reactive protein increased 23.45 9.85 234 237641 94473 63156674
Hyperglycaemia 23.40 9.85 250 237625 41617 63209530
Visual acuity reduced 23.39 9.85 151 237724 21675 63229472
Anhedonia 23.22 9.85 92 237783 10882 63240265
Heart rate decreased 23.16 9.85 267 237608 45293 63205854
Neurosensory hypoacusis 23.14 9.85 13 237862 217 63250930
Hypersensitivity vasculitis 23.10 9.85 49 237826 4063 63247084
Diabetes mellitus inadequate control 23.06 9.85 115 237760 15011 63236136
Hepatotoxicity 23.00 9.85 67 237808 36974 63214173
Nephrocalcinosis 22.81 9.85 24 237851 1054 63250093
Grip strength decreased 22.80 9.85 30 237845 22257 63228890
Urinary incontinence 22.73 9.85 201 237674 31813 63219334
Rhinalgia 22.73 9.85 29 237846 1570 63249577
Bundle branch block left 22.67 9.85 68 237807 6991 63244156
Hypocalcaemia 22.46 9.85 199 237676 31514 63219633
Blood pressure decreased 22.31 9.85 355 237520 64667 63186480
Oropharyngeal swelling 22.21 9.85 22 237853 899 63250248
Intestinal villi atrophy 22.13 9.85 13 237862 237 63250910
Atrioventricular block 22.09 9.85 71 237804 7576 63243571
Myocardial ischaemia 21.95 9.85 101 237774 12758 63238389
Tinnitus 21.94 9.85 217 237658 35411 63215736
Facet joint syndrome 21.90 9.85 9 237866 12129 63239018
Diverticulum 21.83 9.85 96 237779 11895 63239252
Coronary artery occlusion 21.82 9.85 74 237801 8117 63243030
Psoriasis 21.82 9.85 452 237423 86505 63164642
Intestinal malrotation 21.75 9.85 15 237860 365 63250782
Type 2 diabetes mellitus 21.67 9.85 145 237730 63723 63187424
Neutropenic sepsis 21.45 9.85 18 237857 16420 63234727
Dysgeusia 21.24 9.85 268 237607 46442 63204705
Heart rate increased 21.14 9.85 482 237393 93756 63157391
Distributive shock 21.12 9.85 26 237849 1357 63249790
Paraesthesia oral 21.12 9.85 134 237741 19122 63232025
Drug hypersensitivity 21.11 9.85 950 236925 309737 62941410
Gout 21.02 9.85 102 237773 13169 63237978
Overdose 20.96 9.85 304 237571 114774 63136373
Glycosylated haemoglobin increased 20.88 9.85 97 237778 12301 63238846
Somnolence 20.83 9.85 843 237032 177842 63073305
Therapy partial responder 20.75 9.85 7 237868 10651 63240496
Orthostatic intolerance 20.74 9.85 24 237851 1173 63249974
Acute coronary syndrome 20.71 9.85 84 237791 10042 63241105
Electrocardiogram ST segment depression 20.66 9.85 38 237837 2839 63248308
Eosinophilia 20.58 9.85 151 237724 22605 63228542
Dry skin 20.43 9.85 313 237562 56574 63194573
Bronchomalacia 20.37 9.85 12 237863 220 63250927
Interstitial lung disease 20.29 9.85 142 237733 61766 63189381
Pneumothorax spontaneous 20.25 9.85 20 237855 814 63250333
Thrombocytopenia 20.24 9.85 422 237453 150735 63100412
Pancytopenia 20.22 9.85 249 237626 96684 63154463
Blindness 20.20 9.85 145 237730 21554 63229593
Bladder prolapse 20.13 9.85 32 237843 2124 63249023
Micturition disorder 20.12 9.85 35 237840 2503 63248644
Osteonecrosis 20.07 9.85 159 237716 24371 63226776
Adenocarcinoma 19.98 9.85 38 237837 2912 63248235
Premature labour 19.91 9.85 11 237864 12493 63238654
Epilepsy 19.85 9.85 45 237830 27020 63224127
Septic shock 19.85 9.85 157 237718 66472 63184675
Hypoparathyroidism 19.79 9.85 18 237857 660 63250487
Cutaneous lupus erythematosus 19.70 9.85 36 237839 2676 63248471
Device related infection 19.62 9.85 36 237839 23356 63227791
Sopor 19.59 9.85 33 237842 22131 63229016
Intervertebral disc protrusion 19.57 9.85 154 237721 23555 63227592
Hypophagia 19.55 9.85 191 237684 31068 63220079
Cholelithiasis 19.54 9.85 251 237624 43674 63207473
Coronary artery stenosis 19.49 9.85 50 237825 4694 63246453
Azotaemia 19.28 9.85 48 237827 4423 63246724
Bacterial infection 19.15 9.85 132 237743 19367 63231780
Metabolic alkalosis 18.99 9.85 38 237837 3023 63248124
Diplopia 18.98 9.85 153 237722 23575 63227572
Haemodialysis 18.92 9.85 75 237800 8872 63242275
Pain of skin 18.84 9.85 90 237785 11544 63239603
Polymyalgia rheumatica 18.84 9.85 43 237832 3748 63247399
Tooth erosion 18.81 9.85 15 237860 458 63250689
Cardiac stress test abnormal 18.76 9.85 17 237858 620 63250527
Renal artery stenosis 18.75 9.85 29 237846 1880 63249267
Autoimmune disorder 18.75 9.85 22 237853 17155 63233992
Vitamin B1 decreased 18.71 9.85 11 237864 201 63250946
Eye pruritus 18.70 9.85 127 237748 18544 63232603
Ventricular fibrillation 18.64 9.85 91 237784 11776 63239371
Pathological fracture 18.64 9.85 74 237801 8760 63242387
Depressed level of consciousness 18.62 9.85 146 237729 61932 63189215
Disturbance in attention 18.61 9.85 222 237653 37967 63213180
Cyanopsia 18.60 9.85 5 237870 7 63251140
Deep vein thrombosis 18.60 9.85 428 237447 83372 63167775
Dysarthria 18.55 9.85 243 237632 42468 63208679
Amnesia 18.51 9.85 302 237573 55283 63195864
Neurofibrosarcoma 18.51 9.85 10 237865 154 63250993
Liver function test increased 18.50 9.85 62 237813 32749 63218398
Disability 18.46 9.85 25 237850 18322 63232825
Mesenteric panniculitis 18.42 9.85 9 237866 111 63251036
Small cell carcinoma 18.40 9.85 10 237865 156 63250991
Hypertensive heart disease 18.39 9.85 33 237842 2419 63248728
Hip fracture 18.38 9.85 180 237695 29294 63221853
Cytokine release syndrome 18.28 9.85 16 237859 14298 63236849
Sedation 18.22 9.85 79 237796 38730 63212417
Tendon rupture 18.18 9.85 70 237805 8169 63242978
Dysuria 18.18 9.85 200 237675 33538 63217609
Pneumocystis jirovecii pneumonia 18.10 9.85 22 237853 16892 63234255
Acute myocardial infarction 18.04 9.85 192 237683 31932 63219215
Eosinophil count increased 18.04 9.85 85 237790 10843 63240304
Bronchopulmonary aspergillosis 18.02 9.85 5 237870 8630 63242517
Cutaneous T-cell lymphoma 18.01 9.85 24 237851 1356 63249791
Pernicious anaemia 17.94 9.85 17 237858 657 63250490
Transplant rejection 17.88 9.85 9 237866 10771 63240376
Meniscus injury 17.85 9.85 63 237812 7051 63244096
Body height decreased 17.83 9.85 80 237795 9998 63241149
Parkinsonism 17.82 9.85 82 237793 10357 63240790
Asthma 17.79 9.85 614 237261 126947 63124200
Adjustment disorder with depressed mood 17.72 9.85 8 237867 10196 63240951
Forced vital capacity decreased 17.64 9.85 21 237854 1058 63250089
Lip swelling 17.60 9.85 186 237689 30877 63220270
Muscular weakness 17.59 9.85 591 237284 121762 63129385
Diverticulitis 17.57 9.85 226 237649 39331 63211816
Tooth abscess 17.57 9.85 106 237769 14863 63236284
Basal cell carcinoma 17.49 9.85 171 237704 27820 63223327
Fear 17.47 9.85 110 237765 15656 63235491
Hypertensive angiopathy 17.42 9.85 8 237867 85 63251062
Peripheral vascular disorder 17.40 9.85 56 237819 5979 63245168
Fear of injection 17.27 9.85 3 237872 7161 63243986
Lacunar infarction 17.19 9.85 38 237837 3242 63247905
Macular oedema 17.12 9.85 42 237833 3835 63247312
Metastases to fallopian tube 17.07 9.85 7 237868 55 63251092
Skin haemorrhage 17.02 9.85 79 237796 10015 63241132
Skin exfoliation 16.99 9.85 241 237634 42861 63208286
Schizophrenia 16.98 9.85 8 237867 9944 63241203
Diarrhoea 16.90 9.85 2985 234890 712381 62538766
Photosensitivity reaction 16.85 9.85 105 237770 14889 63236258
Hyponatraemic encephalopathy 16.80 9.85 11 237864 245 63250902
Back pain 16.78 9.85 1177 236698 262968 62988179
Osteoarthritis 16.76 9.85 472 237403 94871 63156276
Vulvovaginal burning sensation 16.61 9.85 29 237846 2080 63249067
Rectal prolapse 16.58 9.85 28 237847 1955 63249192
Breast cancer stage II 16.55 9.85 6 237869 8730 63242417
Oesophageal discomfort 16.52 9.85 10 237865 193 63250954
Breath sounds abnormal 16.43 9.85 83 237792 10890 63240257
Endometrial cancer stage I 16.37 9.85 11 237864 256 63250891
Injection site inflammation 16.30 9.85 41 237834 3802 63247345
Adverse event 16.27 9.85 168 237707 67391 63183756
Epstein-Barr virus infection 16.18 9.85 5 237870 8045 63243102
Blood lactic acid decreased 16.09 9.85 9 237866 149 63250998
Meniere's disease 16.08 9.85 10 237865 203 63250944
Petechiae 16.05 9.85 98 237777 13799 63237348
Dementia 16.03 9.85 123 237752 18671 63232476
Bone erosion 16.01 9.85 26 237849 17691 63233456
Acute myopia 15.87 9.85 8 237867 106 63251041
Dystonia 15.85 9.85 17 237858 13802 63237345
Rash papular 15.84 9.85 107 237768 15595 63235552
Anaphylactic reaction 15.67 9.85 165 237710 65935 63185212
Peripheral venous disease 15.66 9.85 21 237854 15456 63235691
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.66 9.85 34 237841 2865 63248282
Vertigo 15.58 9.85 313 237562 59574 63191573
Spinal osteoarthritis 15.56 9.85 109 237766 16077 63235070
Hypertrophic cardiomyopathy 15.44 9.85 24 237851 1563 63249584
Neurotoxicity 15.29 9.85 25 237850 16965 63234182
Mucosal membrane hyperplasia 15.23 9.85 6 237869 42 63251105
Polydipsia 15.10 9.85 38 237837 3526 63247621
Amaurosis fugax 15.09 9.85 13 237862 443 63250704
Ventricular tachycardia 15.00 9.85 127 237748 19852 63231295
Extrasystoles 14.99 9.85 48 237827 5112 63246035
Coronary ostial stenosis 14.95 9.85 7 237868 78 63251069
Cardiac hypertrophy 14.93 9.85 19 237856 1026 63250121
Mandibular mass 14.90 9.85 9 237866 173 63250974
Procalcitonin increased 14.89 9.85 20 237855 1139 63250008
Hypomagnesaemia 14.87 9.85 169 237706 28568 63222579
Dysphagia 14.87 9.85 436 237439 88149 63162998
Jaw disorder 14.85 9.85 49 237826 5300 63245847
Low density lipoprotein increased 14.85 9.85 55 237820 6302 63244845
Carotid bruit 14.84 9.85 16 237859 723 63250424
Renal cyst 14.78 9.85 77 237798 10225 63240922
Hypoparathyroidism secondary 14.76 9.85 6 237869 46 63251101
Torsade de pointes 14.70 9.85 93 237782 13258 63237889
Choroidal effusion 14.61 9.85 13 237862 463 63250684
Neonatal respiratory distress 14.60 9.85 12 237863 383 63250764
Confabulation 14.58 9.85 11 237864 309 63250838
Renal injury 14.56 9.85 72 237803 9367 63241780
Peripheral circulatory failure 14.46 9.85 18 237857 950 63250197
Osmotic demyelination syndrome 14.46 9.85 15 237860 648 63250499
Carpal tunnel syndrome 14.42 9.85 130 237745 20687 63230460
Drug ineffective for unapproved indication 14.42 9.85 72 237803 33991 63217156
Breast neoplasm 14.41 9.85 22 237853 1410 63249737
Device difficult to use 14.39 9.85 16 237859 12780 63238367
Angle closure glaucoma 14.31 9.85 28 237847 2191 63248956
Subacute cutaneous lupus erythematosus 14.28 9.85 31 237844 2612 63248535
Myopathy 14.27 9.85 81 237794 11110 63240037
Chest discomfort 14.27 9.85 525 237350 109444 63141703
Post-anoxic myoclonus 14.25 9.85 5 237870 24 63251123
Lower limb fracture 14.19 9.85 45 237830 24176 63226971
Multiple organ dysfunction syndrome 14.14 9.85 140 237735 56612 63194535
International normalised ratio decreased 14.11 9.85 43 237832 4458 63246689
Crystal arthropathy 14.10 9.85 11 237864 325 63250822
Blood hyposmosis 14.09 9.85 5 237870 25 63251122
Glomerulonephritis rapidly progressive 14.07 9.85 18 237857 977 63250170
Gastroenteritis clostridial 14.01 9.85 14 237861 578 63250569
Cardiac murmur 13.99 9.85 98 237777 14454 63236693
Sleep disorder 13.98 9.85 218 237657 81348 63169799
Dilatation atrial 13.92 9.85 26 237849 1965 63249182
Haematotoxicity 13.87 9.85 9 237866 9367 63241780
Temperature regulation disorder 13.87 9.85 3 237872 6129 63245018
Vaginal flatulence 13.83 9.85 35 237840 3258 63247889
Cardiomegaly 13.77 9.85 113 237762 17501 63233646
Renal artery dissection 13.77 9.85 3 237872 0 63251147
Cardiac ventriculogram left 13.77 9.85 3 237872 0 63251147
Night sweats 13.64 9.85 117 237758 48697 63202450
Abortion induced 13.63 9.85 11 237864 10231 63240916
Respiratory disorder 13.63 9.85 88 237787 38994 63212153
Cytopenia 13.61 9.85 14 237861 11587 63239560
Stupor 13.56 9.85 41 237834 4234 63246913
Liver disorder 13.56 9.85 132 237743 53555 63197592
Gastrointestinal toxicity 13.55 9.85 6 237869 7735 63243412
Pulpitis dental 13.46 9.85 17 237858 911 63250236
Actinic keratosis 13.46 9.85 30 237845 2574 63248573
Intervertebral disc degeneration 13.44 9.85 103 237772 15629 63235518
Therapeutic response unexpected 13.43 9.85 118 237757 18641 63232506
Product residue present 13.41 9.85 39 237836 3940 63247207
Eosinophilia myalgia syndrome 13.39 9.85 4 237871 10 63251137
Left ventricular hypertrophy 13.28 9.85 47 237828 5268 63245879
Osteogenesis imperfecta 13.23 9.85 14 237861 619 63250528
Vision blurred 13.20 9.85 444 237431 91480 63159667
White blood cell count decreased 13.07 9.85 409 237466 138695 63112452
Epileptic encephalopathy 13.07 9.85 10 237865 287 63250860
Coronavirus test positive 13.02 9.85 15 237860 730 63250417
Pollakiuria 13.00 9.85 161 237714 27776 63223371
Orthostatic hypotension 13 9.85 199 237676 35961 63215186
Ultrasound kidney abnormal 12.94 9.85 5 237870 33 63251114
Gastritis 12.92 9.85 204 237671 37099 63214048
Atrioventricular block second degree 12.85 9.85 38 237837 3876 63247271
Accidental exposure to product 12.73 9.85 56 237819 27349 63223798
Blood pressure abnormal 12.70 9.85 99 237776 15099 63236048
Therapeutic product effect incomplete 12.67 9.85 364 237511 124692 63126455
Lipohypertrophy 12.66 9.85 14 237861 651 63250496
Product commingling 12.59 9.85 8 237867 169 63250978
Endometrial hyperplasia 12.57 9.85 16 237859 864 63250283
Chondropathy 12.45 9.85 27 237848 2273 63248874
Osteomyelitis acute 12.37 9.85 9 237866 239 63250908
Blood creatinine abnormal 12.34 9.85 32 237843 3024 63248123
Laryngeal pain 12.31 9.85 41 237834 4457 63246690
Vascular device infection 12.29 9.85 6 237869 7306 63243841
Microalbuminuria 12.28 9.85 11 237864 395 63250752
Endometrial cancer 12.24 9.85 33 237842 3192 63247955
Allergic hepatitis 12.23 9.85 5 237870 39 63251108
Chest wall mass 12.21 9.85 6 237869 75 63251072
Hot flush 12.20 9.85 264 237611 50895 63200252
Product administration error 12.17 9.85 133 237742 22264 63228883
Disseminated intravascular coagulation 12.17 9.85 34 237841 19017 63232130
Unintended pregnancy 12.13 9.85 4 237871 6175 63244972
Non-cardiac chest pain 12.02 9.85 51 237824 6221 63244926
Renal tubular necrosis 12.02 9.85 81 237794 11797 63239350
Pituitary apoplexy 12.00 9.85 7 237868 126 63251021
Lip infection 12.00 9.85 7 237868 126 63251021
Glomerulonephritis 11.91 9.85 23 237852 1783 63249364
Blood creatine increased 11.88 9.85 47 237828 5554 63245593
Procedural complication 11.83 9.85 46 237829 5393 63245754
Rheumatoid factor 11.83 9.85 10 237865 332 63250815
Pharyngeal oedema 11.81 9.85 90 237785 13631 63237516
Ageusia 11.79 9.85 90 237785 13638 63237509
Anaemia postoperative 11.78 9.85 26 237849 2216 63248931
Progressive multifocal leukoencephalopathy 11.76 9.85 19 237856 12952 63238195
Renal impairment 11.75 9.85 423 237452 87932 63163215
Gallbladder disorder 11.72 9.85 115 237760 18727 63232420
Adrenocortical carcinoma 11.71 9.85 5 237870 44 63251103
Gastric atony 11.70 9.85 3 237872 3 63251144
Wound treatment 11.69 9.85 8 237867 192 63250955
Lymphocyte count decreased 11.67 9.85 66 237809 30191 63220956
Upper-airway cough syndrome 11.63 9.85 78 237797 11340 63239807
Diabetic neuropathy 11.63 9.85 37 237838 3927 63247220
Tanning 11.61 9.85 6 237869 84 63251063
Respiratory depression 11.60 9.85 21 237854 13694 63237453
Multiple drug therapy 11.59 9.85 35 237840 3611 63247536
Gait disturbance 11.58 9.85 816 237059 182362 63068785
Gastritis erosive 11.49 9.85 49 237826 5990 63245157
Cutaneous T-cell lymphoma stage I 11.44 9.85 4 237871 19 63251128
Skin pressure mark 11.44 9.85 4 237871 19 63251128
Chronic kidney disease 11.39 9.85 236 237639 45162 63205985
Myelodysplastic syndrome 11.38 9.85 29 237846 16725 63234422
Tremor 11.33 9.85 605 237270 131634 63119513
Memory impairment 11.26 9.85 488 237387 103770 63147377
Vasculitis 11.26 9.85 111 237764 18098 63233049
Nodal rhythm 11.25 9.85 22 237853 1721 63249426
Encephalitis 11.25 9.85 10 237865 8870 63242277
Abdominal panniculectomy 11.25 9.85 3 237872 4 63251143
Diverticulum oesophageal 11.17 9.85 7 237868 144 63251003
Lung disorder 11.15 9.85 165 237710 62096 63189051
Foreign body in reproductive tract 11.13 9.85 14 237861 747 63250400
Hyponatraemic syndrome 11.11 9.85 12 237863 543 63250604
Delayed fontanelle closure 11.11 9.85 4 237871 21 63251126
Device dislocation 11.07 9.85 54 237821 25651 63225496
Macrocytosis 11.06 9.85 27 237848 2458 63248689
Maternal drugs affecting foetus 11.00 9.85 3 237872 5239 63245908
Oesophageal oedema 10.98 9.85 5 237870 52 63251095
Hyperammonaemia 10.97 9.85 3 237872 5229 63245918
Lipoedema 10.90 9.85 9 237866 289 63250858
Dermatitis atopic 10.87 9.85 68 237807 9656 63241491
Oral fibroma 10.82 9.85 5 237870 54 63251093
Vitiligo 10.81 9.85 19 237856 1370 63249777
Chills 10.80 9.85 524 237351 112854 63138293
Muscle twitching 10.78 9.85 117 237758 19551 63231596
Multiple-drug resistance 10.78 9.85 3 237872 5167 63245980
Neuroglycopenia 10.76 9.85 11 237864 467 63250680
Sleep apnoea syndrome 10.73 9.85 161 237714 28972 63222175
Vomiting 10.69 9.85 2311 235564 557306 62693841
Cardiac output increased 10.69 9.85 8 237867 222 63250925
Aphthous ulcer 10.67 9.85 89 237786 13849 63237298
Clostridium difficile infection 10.62 9.85 67 237808 29855 63221292
Retroperitoneal fibrosis 10.62 9.85 9 237866 300 63250847
Hypertrichosis 10.60 9.85 17 237858 1137 63250010
Vascular access site pain 10.58 9.85 6 237869 102 63251045
Non-Hodgkin's lymphoma 10.58 9.85 19 237856 1393 63249754
Adiposis dolorosa 10.51 9.85 9 237866 304 63250843
Eczema weeping 10.50 9.85 3 237872 6 63251141
Haemorrhagic fever 10.50 9.85 3 237872 6 63251141
Femoral bruit 10.50 9.85 3 237872 6 63251141
Iliac artery embolism 10.50 9.85 3 237872 6 63251141
Encephalomalacia 10.47 9.85 11 237864 482 63250665
Thyroid neoplasm 10.44 9.85 36 237839 3983 63247164
Nocturia 10.43 9.85 59 237816 8082 63243065
Fibrosis 10.41 9.85 37 237838 4155 63246992
Paraesthesia 10.41 9.85 702 237173 156264 63094883
Blood potassium abnormal 10.33 9.85 27 237848 2563 63248584
Exposure to toxic agent 10.31 9.85 4 237871 5583 63245564
Prothrombin time abnormal 10.29 9.85 11 237864 492 63250655
Arteriosclerosis coronary artery 10.28 9.85 60 237815 8313 63242834
Antidiuretic hormone abnormality 10.27 9.85 4 237871 27 63251120
Dementia Alzheimer's type 10.27 9.85 16 237859 1044 63250103
Pruritus allergic 10.25 9.85 20 237855 1562 63249585
Immune reconstitution inflammatory syndrome 10.21 9.85 5 237870 6079 63245068
Vulvovaginal pruritus 10.19 9.85 31 237844 3212 63247935
Mouth ulceration 10.16 9.85 77 237798 32907 63218240
Cerebral ischaemia 10.15 9.85 51 237824 6677 63244470
Agranulocytosis 10.14 9.85 54 237821 25080 63226067
Vertebral artery stenosis 10.14 9.85 5 237870 63 63251084
Overweight 10.09 9.85 34 237841 3717 63247430
Endophthalmitis 10.06 9.85 33 237842 3559 63247588
Poor personal hygiene 10.06 9.85 9 237866 323 63250824
Thrombotic microangiopathy 10.02 9.85 15 237860 10546 63240601
Varicose vein ruptured 10.00 9.85 5 237870 65 63251082
Blood pressure systolic abnormal 10.00 9.85 85 237790 13301 63237846
Coma acidotic 10.00 9.85 6 237869 114 63251033
Tricuspid valve incompetence 9.97 9.85 91 237784 14530 63236617
Allergic cough 9.94 9.85 13 237862 721 63250426
Endometrial disorder 9.87 9.85 13 237862 726 63250421
Normal newborn 9.86 9.85 10 237865 8331 63242816

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 458.54 10.35 974 128948 81717 34745292
Angioedema 394.36 10.35 584 129338 36790 34790219
Off label use 295.07 10.35 708 129214 418816 34408193
Hypokalaemia 251.83 10.35 622 129300 57592 34769417
Drug abuse 216.86 10.35 51 129871 99045 34727964
Acute kidney injury 216.68 10.35 1899 128023 303089 34523920
Dizziness 165.00 10.35 1380 128542 217141 34609868
Syncope 155.66 10.35 713 129209 90738 34736271
Cerebrovascular accident 150.90 10.35 670 129252 84141 34742868
Death 150.57 10.35 867 129055 397182 34429827
Coronary artery disease 121.00 10.35 425 129497 47880 34779129
Blood glucose increased 117.82 10.35 526 129396 66192 34760817
Product use in unapproved indication 114.34 10.35 162 129760 117337 34709672
Myocardial infarction 114.23 10.35 806 129116 120279 34706730
Neutropenia 112.47 10.35 261 129661 156517 34670492
Febrile neutropenia 109.69 10.35 214 129708 136635 34690374
Pneumonia 103.22 10.35 858 129064 361769 34465240
Pyrexia 103.09 10.35 770 129152 332243 34494766
Cardiospasm 99.26 10.35 66 129856 1522 34825487
Drug ineffective 97.38 10.35 1159 128763 455592 34371417
Hypotension 96.15 10.35 1251 128671 220398 34606611
Blood pressure inadequately controlled 95.61 10.35 79 129843 2561 34824448
Dehydration 95.31 10.35 816 129106 129153 34697856
Blood pressure increased 94.78 10.35 606 129316 87496 34739513
Carotid artery occlusion 90.23 10.35 89 129833 3648 34823361
Milk-alkali syndrome 89.11 10.35 44 129878 561 34826448
Palmoplantar keratoderma 86.97 10.35 66 129856 1887 34825122
Sepsis 84.32 10.35 326 129596 166235 34660774
Facial pain 83.52 10.35 85 129837 3619 34823390
Pancreatitis acute 81.45 10.35 260 129662 27881 34799128
Toxicity to various agents 81.14 10.35 426 129496 199936 34627073
Pruritus genital 77.84 10.35 65 129857 2139 34824870
Sleep terror 74.98 10.35 65 129857 2253 34824756
Thrombocytopenia 71.48 10.35 318 129604 155929 34671080
Atrial tachycardia 70.36 10.35 77 129845 3568 34823441
Immunisation 70.33 10.35 46 129876 1031 34825978
Blood potassium decreased 69.67 10.35 184 129738 17731 34809278
Tension headache 67.12 10.35 69 129853 2973 34824036
Transient ischaemic attack 64.90 10.35 238 129684 27375 34799634
Anosmia 62.52 10.35 76 129846 3948 34823061
Cytomegalovirus infection 58.02 10.35 13 129909 26122 34800887
Treatment failure 56.57 10.35 54 129868 46643 34780366
Product use issue 54.92 10.35 94 129828 63122 34763887
Pancreatitis 53.11 10.35 285 129637 38606 34788403
Hypertensive crisis 50.60 10.35 105 129817 8646 34818363
IgM nephropathy 50.15 10.35 19 129903 119 34826890
Foetal exposure during pregnancy 49.83 10.35 41 129881 38060 34788949
Cytokine release syndrome 49.55 10.35 12 129910 22865 34804144
Hepatic function abnormal 49.54 10.35 55 129867 44308 34782701
Bundle branch block left 47.30 10.35 82 129840 5897 34821112
Eye pruritus 47.04 10.35 93 129829 7396 34819613
Hypovolaemia 46.76 10.35 105 129817 9129 34817880
Interstitial lung disease 45.68 10.35 110 129812 65172 34761837
Leukopenia 44.71 10.35 105 129817 62751 34764258
Hospitalisation 44.65 10.35 90 129832 56812 34770197
Blood mercury abnormal 43.58 10.35 20 129902 214 34826795
Pain of skin 43.47 10.35 80 129842 6029 34820980
5-hydroxyindolacetic acid in urine increased 41.79 10.35 20 129902 237 34826772
Orthostatic intolerance 41.56 10.35 30 129892 793 34826216
Sprue-like enteropathy 41.25 10.35 25 129897 488 34826521
Myelosuppression 40.01 10.35 11 129911 19254 34807755
Drug intolerance 39.63 10.35 103 129819 59467 34767542
Cardiac failure congestive 38.52 10.35 476 129446 82794 34744215
Lactic acidosis 38.47 10.35 241 129681 34531 34792478
Blood creatinine increased 38.12 10.35 529 129393 94447 34732562
Injury 37.15 10.35 164 129758 20523 34806486
Cardiomegaly 37.06 10.35 134 129788 15304 34811705
Carotid artery stenosis 36.06 10.35 66 129856 4953 34822056
Hypochloraemia 36.01 10.35 25 129897 620 34826389
Interstitial granulomatous dermatitis 35.29 10.35 16 129906 166 34826843
Blood urea increased 35.19 10.35 213 129709 30151 34796858
Drug resistance 35.03 10.35 27 129895 25900 34801109
Tinnitus 35.01 10.35 158 129764 19960 34807049
Metabolic alkalosis 34.86 10.35 35 129887 1466 34825543
Lip swelling 34.79 10.35 135 129787 15945 34811064
Amnesia 34.47 10.35 192 129730 26371 34800638
Renal artery stenosis 33.99 10.35 42 129880 2219 34824790
Blood chloride decreased 33.76 10.35 55 129867 3758 34823251
Muscle twitching 33.37 10.35 99 129823 10199 34816810
Bronchopulmonary aspergillosis 33.13 10.35 7 129915 14652 34812357
Chest pain 32.75 10.35 657 129265 126105 34700904
Pancytopenia 32.74 10.35 213 129709 94944 34732065
Acute myocardial infarction 32.10 10.35 323 129599 53396 34773613
Inappropriate antidiuretic hormone secretion 31.73 10.35 112 129810 12641 34814368
Diplopia 31.37 10.35 135 129787 16708 34810301
Hypomagnesaemia 31.10 10.35 162 129760 21689 34805320
Pulmonary valve disease 30.93 10.35 18 129904 325 34826684
Drug-induced liver injury 30.83 10.35 37 129885 28795 34798214
Bone marrow failure 30.80 10.35 38 129884 29215 34797794
Liver disorder 30.58 10.35 47 129875 32950 34794059
Vasculitis 30.54 10.35 102 129820 11194 34815815
Neutrophil count decreased 29.85 10.35 94 129828 51010 34775999
Arteriosclerosis coronary artery 29.65 10.35 108 129814 12377 34814632
Glycosylated haemoglobin increased 29.33 10.35 101 129821 11259 34815750
Pneumonia aspiration 29.00 10.35 71 129851 41832 34785177
Renal failure 29.00 10.35 662 129260 129895 34697114
Pericardial disease 28.85 10.35 19 129903 431 34826578
Infection 28.56 10.35 209 129713 90706 34736303
Granulomatous pneumonitis 28.53 10.35 9 129913 29 34826980
Hypertension 28.21 10.35 685 129237 135758 34691251
Hypercalcaemia 28.06 10.35 123 129799 15345 34811664
Platelet count decreased 27.98 10.35 297 129625 119420 34707589
Aspergillus infection 27.39 10.35 6 129916 12248 34814761
Erectile dysfunction 27.33 10.35 150 129772 20487 34806522
Bacteraemia 27.32 10.35 20 129902 19697 34807312
Blood pressure systolic increased 27.23 10.35 162 129760 22790 34804219
Low density lipoprotein decreased 27.18 10.35 27 129895 1116 34825893
Sopor 27.01 10.35 6 129916 12130 34814879
Neurotoxicity 26.65 10.35 17 129905 17993 34809016
Lower respiratory tract infection 26.60 10.35 48 129874 31589 34795420
Intentional self-injury 26.55 10.35 9 129913 13762 34813247
Blood sodium decreased 26.33 10.35 125 129797 16126 34810883
Visual impairment 26.28 10.35 225 129697 35577 34791432
Angina pectoris 25.66 10.35 202 129720 31161 34795848
Blindness 25.55 10.35 117 129805 14869 34812140
Fall 25.55 10.35 958 128964 201927 34625082
Hypertensive emergency 25.54 10.35 25 129897 1015 34825994
Nodular rash 25.53 10.35 11 129911 100 34826909
Actinic keratosis 25.47 10.35 54 129868 4513 34822496
Choroidal effusion 25.38 10.35 13 129909 180 34826829
Rash papular 25.34 10.35 90 129832 10188 34816821
Vertigo 25.20 10.35 172 129750 25364 34801645
Mitral valve incompetence 24.99 10.35 116 129806 14827 34812182
Ventricular tachycardia 24.46 10.35 176 129746 26403 34800606
Disseminated intravascular coagulation 24.40 10.35 27 129895 21789 34805220
Oedema peripheral 24.00 10.35 599 129323 119213 34707796
Peritonitis 23.46 10.35 16 129906 16349 34810660
Hyperhidrosis 23.23 10.35 403 129519 75289 34751720
Blood triglycerides increased 23.01 10.35 109 129813 14050 34812959
C-reactive protein increased 22.98 10.35 113 129809 53985 34773024
Drug dependence 22.92 10.35 34 129888 24183 34802826
Choroidal detachment 22.73 10.35 16 129906 406 34826603
Lichen planus 22.66 10.35 23 129899 976 34826033
Mucosal inflammation 22.58 10.35 71 129851 38551 34788458
Hepatic neoplasm 22.43 10.35 32 129890 1945 34825064
Muscular weakness 22.33 10.35 388 129534 72509 34754500
Bradycardia 22.24 10.35 399 129523 75019 34751990
Angina unstable 22.16 10.35 94 129828 11559 34815450
Lymphocyte count decreased 22.16 10.35 31 129891 22591 34804418
Graft versus host disease 22.01 10.35 6 129916 10563 34816446
Malignant neoplasm progression 21.98 10.35 215 129707 87831 34739178
Renal injury 21.83 10.35 91 129831 11104 34815905
Multiple organ dysfunction syndrome 21.71 10.35 181 129741 76385 34750624
Physical examination abnormal 21.71 10.35 14 129908 306 34826703
Septic shock 21.67 10.35 167 129755 71667 34755342
Polydipsia 21.50 10.35 46 129876 3869 34823140
High density lipoprotein decreased 21.43 10.35 42 129880 3318 34823691
Disease progression 21.43 10.35 278 129644 107799 34719210
Pneumocystis jirovecii pneumonia 21.39 10.35 25 129897 19685 34807324
Swollen tongue 21.28 10.35 109 129813 14496 34812513
Aplastic anaemia 21.23 10.35 5 129917 9711 34817298
Tricuspid valve incompetence 21.16 10.35 82 129840 9678 34817331
Vestibular neuronitis 21.16 10.35 12 129910 206 34826803
Inappropriate schedule of product administration 21.13 10.35 140 129782 62156 34764853
Ascites 21.12 10.35 95 129827 46476 34780533
Congenital diaphragmatic anomaly 21.03 10.35 7 129915 28 34826981
Osteoarthritis 20.94 10.35 140 129782 20502 34806507
Hyperlipidaemia 20.87 10.35 108 129814 14421 34812588
Arrhythmia 20.76 10.35 214 129708 35594 34791415
Therapeutic product effect incomplete 20.65 10.35 107 129815 50434 34776575
Sedation 20.36 10.35 29 129893 20977 34806032
Akathisia 20.22 10.35 3 129919 8106 34818903
Immune reconstitution inflammatory syndrome 20.17 10.35 4 129918 8755 34818254
Heart rate increased 20.17 10.35 262 129660 46081 34780928
Blood cholesterol increased 20.05 10.35 138 129784 20405 34806604
Pseudolymphoma 20.05 10.35 18 129904 654 34826355
Palpitations 19.97 10.35 232 129690 39754 34787255
Pulmonary valve stenosis congenital 19.95 10.35 10 129912 132 34826877
Drug ineffective for unapproved indication 19.92 10.35 36 129886 23679 34803330
Blood pressure decreased 19.87 10.35 285 129637 51230 34775779
Migraine 19.86 10.35 122 129800 17356 34809653
Stomatitis 19.72 10.35 86 129836 42428 34784581
Ventricular hypertrophy 19.65 10.35 49 129873 4558 34822451
Colitis 19.63 10.35 73 129849 37677 34789332
Subarachnoid haemorrhage 19.62 10.35 96 129826 12539 34814470
Acquired acrodermatitis enteropathica 19.55 10.35 5 129917 5 34827004
Contraindicated product administered 19.52 10.35 31 129891 21450 34805559
Microalbuminuria 19.38 10.35 18 129904 684 34826325
Gout 19.19 10.35 130 129792 19123 34807886
Intestinal villi atrophy 19.18 10.35 10 129912 144 34826865
Condition aggravated 19.10 10.35 556 129366 191640 34635369
Lymphomatoid papulosis 19.08 10.35 11 129911 195 34826814
Alkalosis hypochloraemic 18.85 10.35 13 129909 319 34826690
Shock 18.83 10.35 154 129768 24025 34802984
Extrasystoles 18.83 10.35 43 129879 3780 34823229
Dry skin 18.62 10.35 188 129734 31099 34795910
Electrolyte imbalance 18.58 10.35 104 129818 14308 34812701
Synovitis 18.56 10.35 15 129907 14051 34812958
Pharyngeal oedema 18.53 10.35 57 129865 5990 34821019
Product complaint 18.50 10.35 56 129866 5834 34821175
Pericarditis 18.45 10.35 89 129833 11556 34815453
Aortic valve incompetence 18.41 10.35 56 129866 5848 34821161
CD4/CD8 ratio increased 18.40 10.35 4 129918 0 34827009
Renin decreased 18.40 10.35 4 129918 0 34827009
Drug reaction with eosinophilia and systemic symptoms 18.39 10.35 62 129860 32950 34794059
Fatigue 18.33 10.35 1607 128315 369046 34457963
Pancreatitis necrotising 18.23 10.35 35 129887 2723 34824286
Hypophagia 18.17 10.35 152 129770 23870 34803139
Transaminases increased 18.12 10.35 46 129876 26777 34800232
Toxic epidermal necrolysis 18.05 10.35 33 129889 21613 34805396
Seizure 17.86 10.35 278 129644 104579 34722430
Dystonia 17.82 10.35 9 129913 10836 34816173
Mastitis 17.77 10.35 10 129912 169 34826840
Hyperkalaemia 17.68 10.35 359 129563 69030 34757979
Therapy non-responder 17.66 10.35 80 129842 39066 34787943
Mitral valve disease 17.64 10.35 24 129898 1395 34825614
Muscle necrosis 17.59 10.35 19 129903 867 34826142
Psoriasis 17.56 10.35 221 129701 38591 34788418
Renal artery stent placement 17.54 10.35 5 129917 10 34826999
Renal artery angioplasty 17.54 10.35 5 129917 10 34826999
Spinal cord infarction 17.52 10.35 12 129910 291 34826718
Cytopenia 17.51 10.35 13 129909 12710 34814299
Electrocardiogram Q wave abnormal 17.45 10.35 14 129908 435 34826574
Precancerous skin lesion 17.44 10.35 16 129906 598 34826411
Hemiparesis 17.22 10.35 109 129813 15669 34811340
Premature baby 17.22 10.35 29 129893 19604 34807405
Infusion related reaction 17.12 10.35 121 129801 52936 34774073
Miosis 17.09 10.35 7 129915 9528 34817481
Myocardial ischaemia 17.02 10.35 117 129805 17291 34809718
Sinus bradycardia 17.01 10.35 94 129828 12869 34814140
Expired product administered 16.92 10.35 38 129884 3303 34823706
Renal tubular necrosis 16.91 10.35 108 129814 15572 34811437
Haemophagocytic lymphohistiocytosis 16.91 10.35 14 129908 12959 34814050
Low density lipoprotein increased 16.67 10.35 45 129877 4391 34822618
Coronary arterial stent insertion 16.65 10.35 43 129879 4086 34822923
Laryngeal cleft 16.64 10.35 5 129917 13 34826996
Left ventricular hypertrophy 16.57 10.35 67 129855 8063 34818946
Carcinoid tumour of the gastrointestinal tract 16.50 10.35 7 129915 61 34826948
Gastrointestinal tract mucosal pigmentation 16.38 10.35 14 129908 476 34826533
Hormone level abnormal 16.37 10.35 13 129909 398 34826611
Transplant rejection 16.29 10.35 9 129913 10302 34816707
Neoplasm 16.26 10.35 51 129871 5416 34821593
Polyuria 16.18 10.35 69 129853 8505 34818504
Occult blood 16.17 10.35 18 129904 850 34826159
Lymphangiectasia intestinal 16.17 10.35 4 129918 3 34827006
Coronary artery occlusion 16.11 10.35 82 129840 10880 34816129
Kidney transplant rejection 16.10 10.35 4 129918 7493 34819516
Tumour lysis syndrome 16.09 10.35 24 129898 17035 34809974
Alanine aminotransferase increased 15.96 10.35 208 129714 80607 34746402
Ventricular arrhythmia 15.92 10.35 51 129871 5477 34821532
Enterocolitis 15.90 10.35 5 129917 8021 34818988
Anhedonia 15.86 10.35 63 129859 7522 34819487
Paresis cranial nerve 15.67 10.35 7 129915 70 34826939
Atrial fibrillation 15.63 10.35 579 129343 121814 34705195
White blood cell count decreased 15.60 10.35 255 129667 95190 34731819
Gastrointestinal angiodysplasia 15.55 10.35 15 129907 598 34826411
Neutropenic sepsis 15.44 10.35 17 129905 13750 34813259
Fluid intake reduced 15.40 10.35 39 129883 3662 34823347
Exposure during pregnancy 15.31 10.35 7 129915 8927 34818082
Shoshin beriberi 15.24 10.35 7 129915 75 34826934
Dysgeusia 15.19 10.35 158 129764 26339 34800670
Eosinophilic colitis 15.18 10.35 10 129912 227 34826782
Product monitoring error 15.04 10.35 43 129879 4338 34822671
Pleural effusion 14.98 10.35 213 129709 81333 34745676
Myalgia 14.95 10.35 414 129508 83696 34743313
Acute cutaneous lupus erythematosus 14.93 10.35 7 129915 79 34826930
Dilatation atrial 14.92 10.35 27 129895 2008 34825001
Diastolic dysfunction 14.90 10.35 54 129868 6173 34820836
Incorrect route of product administration 14.88 10.35 20 129902 14825 34812184
Vascular purpura 14.87 10.35 25 129897 1753 34825256
Supraventricular tachycardia 14.85 10.35 81 129841 11036 34815973
Febrile bone marrow aplasia 14.75 10.35 6 129916 8203 34818806
Substance abuse 14.72 10.35 5 129917 7636 34819373
Hemiataxia 14.70 10.35 6 129916 47 34826962
Type 2 diabetes mellitus 14.65 10.35 106 129816 15926 34811083
Supraventricular extrasystoles 14.63 10.35 37 129885 3471 34823538
Orthostatic hypotension 14.60 10.35 154 129768 25765 34801244
Aggression 14.54 10.35 85 129837 38879 34788130
Arteriosclerosis 14.53 10.35 85 129837 11883 34815126
Intentional product use issue 14.53 10.35 147 129775 59669 34767340
Aortic arteriosclerosis 14.48 10.35 44 129878 4592 34822417
Electrocardiogram U-wave abnormality 14.48 10.35 6 129916 49 34826960
Fear 14.45 10.35 77 129845 10399 34816610
Epilepsy 14.42 10.35 37 129885 21458 34805551
Agitation 14.38 10.35 140 129782 57259 34769750
Therapy partial responder 14.33 10.35 9 129913 9607 34817402
Pathogen resistance 13.96 10.35 9 129913 9473 34817536
Infective pulmonary exacerbation of cystic fibrosis 13.90 10.35 4 129918 6797 34820212
Waist circumference increased 13.89 10.35 17 129905 889 34826120
Atrioventricular block first degree 13.88 10.35 52 129870 6040 34820969
Shock hypoglycaemic 13.79 10.35 7 129915 95 34826914
Tendon rupture 13.67 10.35 57 129865 6955 34820054
Cardiac discomfort 13.64 10.35 14 129908 602 34826407
Patent ductus arteriosus 13.60 10.35 35 129887 3319 34823690
Renin increased 13.60 10.35 7 129915 98 34826911
Preternatural anus 13.60 10.35 7 129915 98 34826911
Torsade de pointes 13.59 10.35 58 129864 7151 34819858
Carcinogenicity 13.52 10.35 6 129916 59 34826950
Brain stem infarction 13.46 10.35 20 129902 1262 34825747
Abdominal discomfort 13.45 10.35 304 129618 59531 34767478
Angiopathy 13.41 10.35 40 129882 4133 34822876
Rhabdomyolysis 13.40 10.35 340 129582 67823 34759186
Acute myeloid leukaemia 13.40 10.35 30 129892 18240 34808769
Coma 13.39 10.35 107 129815 45571 34781438
Osteitis deformans 13.38 10.35 5 129917 30 34826979
Echocardiogram abnormal 13.25 10.35 18 129904 1045 34825964
Intestinal angioedema 13.15 10.35 9 129913 218 34826791
Basal cell carcinoma 13.11 10.35 121 129801 19537 34807472
Bundle branch block right 13.05 10.35 59 129863 7457 34819552
Pruritus 13.04 10.35 649 129273 141332 34685677
Balance disorder 13.03 10.35 218 129704 40436 34786573
Coronary artery bypass 13.02 10.35 44 129878 4858 34822151
Gouty arthritis 12.95 10.35 18 129904 1068 34825941
Renal artery restenosis 12.89 10.35 4 129918 12 34826997
Hypercalciuria 12.88 10.35 10 129912 296 34826713
Appendicitis 12.87 10.35 22 129900 14785 34812224
Atrioventricular block second degree 12.83 10.35 37 129885 3751 34823258
Pyelitis 12.83 10.35 7 129915 111 34826898
Asthenia 12.82 10.35 1068 128854 244183 34582826
Photosensitivity reaction 12.71 10.35 75 129847 10519 34816490
Weaning failure 12.66 10.35 9 129913 232 34826777
Meningitis streptococcal 12.61 10.35 5 129917 36 34826973
Forced expiratory flow decreased 12.56 10.35 8 129914 171 34826838
Hyperammonaemia 12.56 10.35 4 129918 6363 34820646
Abnormal behaviour 12.52 10.35 49 129873 24920 34802089
Respiratory depression 12.48 10.35 26 129896 16219 34810790
Macular ischaemia 12.47 10.35 6 129916 72 34826937
Fibrous histiocytoma 12.44 10.35 8 129914 174 34826835
Electrocardiogram QT interval 12.38 10.35 5 129917 38 34826971
High frequency ablation 12.36 10.35 8 129914 176 34826833
Dermatosis 12.26 10.35 10 129912 318 34826691
Hypoaesthesia 12.23 10.35 307 129615 61137 34765872
Enterococcal infection 12.18 10.35 10 129912 9296 34817713
Post procedural haematoma 12.16 10.35 21 129901 1505 34825504
Hepatojugular reflux 12.13 10.35 13 129909 588 34826421
Accelerated hypertension 12.11 10.35 9 129913 249 34826760
Parotitis 12.11 10.35 17 129905 1018 34825991
Urine albumin/creatinine ratio increased 12.08 10.35 9 129913 250 34826759
Gastrointestinal mucosal necrosis 12.05 10.35 8 129914 184 34826825
Cutaneous T-cell lymphoma 12.04 10.35 21 129901 1517 34825492
Dermatomyositis 12.04 10.35 19 129903 1264 34825745
Drug hypersensitivity 11.91 10.35 219 129703 80310 34746699
Neutrophil count increased 11.90 10.35 29 129893 17117 34809892
Mydriasis 11.90 10.35 6 129916 7231 34819778
Electrocardiogram QT prolonged 11.83 10.35 216 129706 40736 34786273
Productive cough 11.83 10.35 87 129835 37726 34789283
Aortic valve stenosis 11.79 10.35 29 129893 2674 34824335
Hypertensive heart disease 11.77 10.35 27 129895 2381 34824628
Suture insertion 11.65 10.35 5 129917 45 34826964
Atrioventricular block 11.63 10.35 60 129862 8003 34819006
Device leakage 11.51 10.35 5 129917 6570 34820439
Cataract nuclear 11.50 10.35 12 129910 526 34826483
Peripheral vascular disorder 11.49 10.35 43 129879 4993 34822016
Pemphigoid 11.48 10.35 63 129859 8603 34818406
Vision blurred 11.44 10.35 237 129685 45726 34781283
Gait disturbance 11.41 10.35 405 129517 84735 34742274
Stenosis 11.39 10.35 20 129902 1453 34825556
Device pacing issue 11.37 10.35 5 129917 48 34826961
Myosclerosis 11.34 10.35 9 129913 275 34826734
Immunoglobulin G4 related disease 11.31 10.35 7 129915 142 34826867
Malaise 11.27 10.35 570 129352 185255 34641754
Weight loss poor 11.26 10.35 8 129914 206 34826803
Agranulocytosis 11.16 10.35 48 129874 23773 34803236
Squamous cell carcinoma 11.15 10.35 77 129845 11398 34815611
Lymphopenia 11.05 10.35 28 129894 16307 34810702
Indifference 11.02 10.35 7 129915 149 34826860
Thrombotic microangiopathy 10.99 10.35 14 129908 10616 34816393
Oesophageal carcinoma 10.98 10.35 11 129911 9293 34817716
Nail discolouration 10.94 10.35 16 129906 995 34826014
Therapeutic response shortened 10.94 10.35 7 129915 7397 34819612
Therapeutic response decreased 10.91 10.35 64 129858 29249 34797760
Prothrombin time prolonged 10.91 10.35 66 129856 9340 34817669
Renal function test abnormal 10.88 10.35 27 129895 2503 34824506
Multiple-drug resistance 10.86 10.35 3 129919 5236 34821773
Left ventricular dysfunction 10.84 10.35 69 129853 9938 34817071
Constipation 10.82 10.35 408 129514 136574 34690435
Emotional distress 10.80 10.35 94 129828 14932 34812077
Lung disorder 10.77 10.35 80 129842 34616 34792393
Nephropathy 10.69 10.35 47 129875 5870 34821139
Rales 10.62 10.35 68 129854 9815 34817194
Liver function test increased 10.62 10.35 24 129898 14541 34812468
Anhidrosis 10.58 10.35 6 129916 103 34826906
Loss of proprioception 10.55 10.35 10 129912 390 34826619
Pneumothorax 10.53 10.35 36 129886 19056 34807953
Schizophrenia 10.51 10.35 10 129912 8656 34818353
Abdominal tenderness 10.44 10.35 36 129886 4015 34822994
Posterior reversible encephalopathy syndrome 10.40 10.35 13 129909 9941 34817068
Carotid arteriosclerosis 10.40 10.35 22 129900 1836 34825173
Mechanical urticaria 10.38 10.35 6 129916 107 34826902
Left ventricle outflow tract obstruction 10.36 10.35 7 129915 166 34826843

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1535.28 9.75 2512 289652 175336 79276888
Hypokalaemia 677.86 9.75 1576 290588 142464 79309760
Angioedema 537.18 9.75 984 291180 75051 79377173
Acute kidney injury 471.89 9.75 3386 288778 516018 78936206
Off label use 463.93 9.75 1737 290427 905478 78546746
Drug abuse 332.59 9.75 92 292072 162599 79289625
Cerebrovascular accident 319.58 9.75 1270 290894 154022 79298202
Myocardial infarction 312.45 9.75 1420 290744 182709 79269515
Maternal exposure during pregnancy 307.04 9.75 63 292101 136475 79315749
Hand deformity 293.40 9.75 23 292141 103896 79348328
Pemphigus 286.97 9.75 20 292144 99562 79352662
Blood pressure increased 275.04 9.75 1512 290652 209848 79242376
Coronary artery disease 265.62 9.75 677 291487 64797 79387427
Syncope 249.92 9.75 1308 290856 178141 79274083
Blood potassium decreased 228.52 9.75 518 291646 45994 79406230
Dizziness 223.08 9.75 2924 289240 523517 78928707
Systemic lupus erythematosus 221.92 9.75 83 292081 121066 79331158
Dehydration 221.69 9.75 1613 290551 246574 79205650
Synovitis 216.32 9.75 143 292021 150591 79301633
Drug ineffective 216.16 9.75 2733 289431 1078180 78374044
Duodenal ulcer perforation 207.38 9.75 8 292156 66203 79386021
Drug intolerance 188.58 9.75 431 291733 263688 79188536
Glossodynia 187.26 9.75 72 292092 103265 79348959
Product use in unapproved indication 178.36 9.75 409 291755 249950 79202274
Blood glucose increased 177.53 9.75 863 291301 114112 79338112
Treatment failure 176.37 9.75 219 291945 170267 79281957
Hypotension 171.27 9.75 2409 289755 437908 79014316
Lower respiratory tract infection 164.27 9.75 139 292025 129081 79323143
Transient ischaemic attack 162.40 9.75 493 291671 52202 79400022
Contraindicated product administered 162.30 9.75 203 291961 157335 79294889
Exposure during pregnancy 160.52 9.75 85 292079 101047 79351177
Cardiospasm 156.12 9.75 115 292049 3186 79449038
Neutropenia 154.71 9.75 538 291626 287172 79165052
Death 154.15 9.75 1331 290833 565183 78887041
Febrile neutropenia 151.44 9.75 394 291770 230605 79221619
Inappropriate antidiuretic hormone secretion 146.24 9.75 308 291856 26005 79426219
Lactic acidosis 144.26 9.75 575 291589 69784 79382440
Palmoplantar keratoderma 144.02 9.75 115 292049 3601 79448623
Blood pressure inadequately controlled 143.28 9.75 143 292021 6034 79446190
Atrial tachycardia 129.62 9.75 145 292019 6988 79445236
Infection 128.56 9.75 454 291710 241258 79210966
Sprue-like enteropathy 127.39 9.75 72 292092 1246 79450978
Pruritus genital 127.13 9.75 116 292048 4370 79447854
Pneumonia 125.65 9.75 1685 290479 658561 78793663
Folliculitis 125.61 9.75 25 292139 55355 79396869
Sleep terror 123.85 9.75 114 292050 4344 79447880
Muscle injury 123.42 9.75 16 292148 48545 79403679
Carotid artery occlusion 123.06 9.75 146 292018 7501 79444723
Pancreatitis acute 120.45 9.75 428 291736 49176 79403048
Sleep disorder due to general medical condition, insomnia type 119.20 9.75 11 292153 43545 79408679
Milk-alkali syndrome 117.16 9.75 70 292094 1350 79450874
Fall 116.49 9.75 2467 289697 485162 78967062
Condition aggravated 115.95 9.75 1225 290939 499899 78952325
Tension headache 110.02 9.75 134 292030 7077 79445147
Pyrexia 108.74 9.75 1791 290373 676918 78775306
Toxicity to various agents 108.54 9.75 1004 291160 420536 79031688
Rheumatoid factor positive 107.89 9.75 42 292122 59797 79392427
Anosmia 107.72 9.75 147 292017 8697 79443527
Hypovolaemia 107.66 9.75 215 291949 17476 79434748
Irritable bowel syndrome 105.29 9.75 48 292116 62193 79390031
Product use issue 104.42 9.75 405 291759 209417 79242807
Hypertensive crisis 103.88 9.75 233 291931 20537 79431687
Sepsis 103.85 9.75 571 291593 268857 79183367
Immunisation 103.62 9.75 76 292088 2091 79450133
Cardiac failure congestive 102.52 9.75 881 291283 141521 79310703
Chest pain 100.66 9.75 1522 290642 280782 79171442
Helicobacter infection 100.14 9.75 66 292098 69638 79382586
Therapeutic product effect decreased 99.50 9.75 290 291874 163573 79288651
Arthropathy 97.97 9.75 327 291837 176784 79275440
Hypochloraemia 97.83 9.75 78 292086 2437 79449787
Cytomegalovirus infection 97.24 9.75 19 292145 42625 79409599
Facial pain 96.35 9.75 167 291997 12183 79440041
Myelosuppression 96.11 9.75 16 292148 40280 79411944
Infusion related reaction 93.70 9.75 479 291685 229758 79222466
Pericarditis 93.70 9.75 148 292016 104088 79348136
Hepatic function abnormal 91.24 9.75 80 292084 73027 79379197
Wound 89.98 9.75 181 291983 115998 79336226
Discomfort 86.36 9.75 209 291955 125408 79326816
Hypertension 84.98 9.75 1693 290471 329299 79122925
Blister 84.35 9.75 196 291968 119280 79332944
Hypertensive emergency 82.83 9.75 74 292090 2711 79449513
Thrombocytopenia 82.72 9.75 600 291564 264659 79187565
Stomatitis 81.82 9.75 270 291894 146487 79305737
Renal failure 81.76 9.75 1109 291055 199859 79252365
Palpitations 81.73 9.75 765 291399 125845 79326379
Asthenia 80.45 9.75 2448 289716 509241 78942983
Neutrophil count decreased 79.26 9.75 139 292025 93820 79358404
Angina pectoris 77.44 9.75 385 291779 51347 79400877
Intentional self-injury 77.04 9.75 13 292151 32406 79419818
Joint swelling 76.17 9.75 683 291481 287963 79164261
Blood sodium decreased 75.70 9.75 281 291883 32974 79419250
Alopecia 74.72 9.75 518 291646 230837 79221387
Gastrooesophageal reflux disease 72.43 9.75 640 291524 103606 79348618
Therapy non-responder 72.16 9.75 143 292021 92162 79360062
Lung diffusion test abnormal 72.04 9.75 33 292131 357 79451867
Blood pressure systolic increased 70.15 9.75 453 291711 66533 79385691
Bundle branch block left 67.77 9.75 138 292026 11375 79440849
Abortion spontaneous 67.59 9.75 13 292151 29494 79422730
Blood urea increased 67.38 9.75 355 291809 48435 79403789
Angina unstable 66.07 9.75 170 291994 16357 79435867
Drug resistance 64.76 9.75 37 292127 42176 79410048
C-reactive protein abnormal 63.97 9.75 50 292114 48317 79403907
Disease progression 63.94 9.75 404 291760 183958 79268266
Hypercalcaemia 63.30 9.75 294 291870 38136 79414088
Drug interaction 62.98 9.75 1978 290186 413205 79039019
Hyperlipidaemia 62.36 9.75 224 291940 25869 79426355
Pain of skin 62.27 9.75 154 292010 14459 79437765
Swelling 61.98 9.75 502 291662 216209 79236015
Blood creatinine increased 61.55 9.75 852 291312 154205 79298019
Cytokine release syndrome 60.51 9.75 28 292136 35970 79416254
Hyperkalaemia 59.37 9.75 661 291503 113737 79338487
Pregnancy 59.08 9.75 13 292151 26838 79425386
Hepatic enzyme increased 58.88 9.75 409 291755 182201 79270023
Sinus bradycardia 58.87 9.75 215 291949 25032 79427192
Leukopenia 58.50 9.75 224 291940 116289 79335935
Pancreatitis 57.86 9.75 440 291724 68135 79384089
Interstitial lung disease 57.49 9.75 215 291949 112385 79339839
Orthostatic intolerance 56.98 9.75 51 292113 1873 79450351
Malignant neoplasm progression 56.38 9.75 281 291883 135709 79316515
Subarachnoid haemorrhage 55.91 9.75 207 291957 24258 79427966
Red blood cell sedimentation rate abnormal 55.52 9.75 6 292158 20957 79431267
Product complaint 55.11 9.75 139 292025 13210 79439014
Mobility decreased 54.43 9.75 246 291918 121929 79330295
Blood pressure diastolic decreased 54.14 9.75 237 291927 29979 79422245
Carotid artery stenosis 53.97 9.75 107 292057 8651 79443573
Intentional product use issue 53.42 9.75 332 291832 151780 79300444
Platelet count decreased 53.36 9.75 456 291708 194208 79258016
Live birth 53.31 9.75 4 292160 18740 79433484
Loss of employment 52.96 9.75 56 292108 2531 79449693
Blood chloride decreased 52.93 9.75 102 292062 8075 79444149
Bronchopulmonary aspergillosis 52.84 9.75 9 292155 22285 79429939
Impaired healing 51.84 9.75 157 292007 87498 79364726
Oedema peripheral 51.80 9.75 1250 290914 251038 79201186
Pancytopenia 51.59 9.75 375 291789 165370 79286854
Acute myocardial infarction 50.97 9.75 468 291696 76568 79375656
Hypoglycaemia 50.44 9.75 582 291582 101012 79351212
IgM nephropathy 50.41 9.75 19 292145 119 79452105
Psoriatic arthropathy 49.57 9.75 135 292029 77864 79374360
Eye pruritus 49.51 9.75 177 291987 20393 79431831
Bone marrow failure 49.39 9.75 69 292095 51038 79401186
Ventricular hypertrophy 49.21 9.75 90 292074 6848 79445376
Bradycardia 49.08 9.75 733 291431 134824 79317400
Mitral valve incompetence 48.13 9.75 220 291944 28345 79423879
Arterial occlusive disease 47.00 9.75 99 292065 8357 79443867
Hypersensitivity 45.87 9.75 680 291484 261559 79190665
Diplopia 45.86 9.75 243 291921 33223 79419001
Renal artery stenosis 45.66 9.75 60 292104 3422 79448802
5-hydroxyindolacetic acid in urine increased 44.99 9.75 21 292143 238 79451986
Septic shock 44.70 9.75 265 291899 122536 79329688
Product monitoring error 44.63 9.75 100 292064 8806 79443418
Intestinal angioedema 44.57 9.75 32 292132 851 79451373
Atrial fibrillation 44.48 9.75 993 291171 196893 79255331
Electrolyte imbalance 44.23 9.75 227 291937 30654 79421570
Blood mercury abnormal 43.85 9.75 20 292144 214 79452010
Hyperhidrosis 43.65 9.75 789 291375 150703 79301521
Multiple organ dysfunction syndrome 43.50 9.75 260 291904 119986 79332238
Rhabdomyolysis 42.68 9.75 571 291593 102560 79349664
Sopor 42.56 9.75 35 292129 32975 79419249
Glycosylated haemoglobin increased 42.38 9.75 161 292003 19099 79433125
Ventricular tachycardia 42.32 9.75 281 291883 41654 79410570
Myocardial ischaemia 41.86 9.75 195 291969 25324 79426900
Amnesia 41.67 9.75 383 291781 62674 79389550
Rash papular 41.65 9.75 175 291989 21741 79430483
Blindness 41.60 9.75 210 291954 28173 79424051
Arrhythmia 41.43 9.75 374 291790 60898 79391326
Hypomagnesaemia 41.27 9.75 304 291860 46607 79405617
Hip arthroplasty 41.24 9.75 42 292122 35714 79416510
Epstein-Barr virus infection 41.22 9.75 3 292161 14413 79437811
Metabolic alkalosis 40.78 9.75 65 292099 4424 79447800
Cardiomegaly 40.78 9.75 198 291966 26154 79426070
Pemphigoid 40.53 9.75 136 292028 15179 79437045
Hospitalisation 40.05 9.75 193 291971 94043 79358181
Lip swelling 40.00 9.75 272 291892 40639 79411585
Eosinophilic bronchitis 39.94 9.75 24 292140 468 79451756
Swollen tongue 39.84 9.75 280 291884 42290 79409934
Atrioventricular block first degree 39.54 9.75 118 292046 12373 79439851
Arteriosclerosis coronary artery 39.26 9.75 149 292015 17667 79434557
Emotional distress 39.24 9.75 266 291898 39703 79412521
Vasculitis 39.12 9.75 189 291975 24913 79427311
Drug ineffective for unapproved indication 38.66 9.75 81 292083 51157 79401067
Nausea 38.38 9.75 4035 288129 953161 78499063
Sedation 38.35 9.75 83 292081 51812 79400412
Haemophagocytic lymphohistiocytosis 38.26 9.75 16 292148 21821 79430403
Ill-defined disorder 38.23 9.75 119 292045 65756 79386468
Supraventricular extrasystoles 37.91 9.75 81 292083 6906 79445318
Tinnitus 37.70 9.75 285 291879 44048 79408176
Choroidal effusion 37.57 9.75 26 292138 651 79451573
Anhedonia 37.41 9.75 130 292034 14768 79437456
Arteriosclerosis 37.37 9.75 149 292015 18078 79434146
Lymphocyte count decreased 37.18 9.75 73 292091 47216 79405008
C-reactive protein increased 36.81 9.75 299 291865 128728 79323496
Liver injury 36.72 9.75 97 292067 56517 79395707
Pneumocystis jirovecii pneumonia 36.57 9.75 39 292125 32469 79419755
Hypophagia 36.55 9.75 288 291876 45079 79407145
Acute myeloid leukaemia 35.94 9.75 36 292128 30849 79421375
Graft versus host disease 35.76 9.75 6 292158 15020 79437204
Fibromyalgia 34.73 9.75 120 292044 64220 79388004
Liver disorder 34.58 9.75 142 292022 72275 79379949
Neurotoxicity 34.41 9.75 41 292123 32477 79419747
Rash 34.40 9.75 1750 290414 576608 78875616
Bacteraemia 34.09 9.75 42 292122 32782 79419442
Muscle twitching 34.06 9.75 180 291984 24584 79427640
Disseminated intravascular coagulation 34.02 9.75 49 292115 35793 79416431
Allergic oedema 33.95 9.75 26 292138 765 79451459
Dystonia 33.92 9.75 18 292146 21381 79430843
Sedation complication 33.65 9.75 8 292156 15661 79436563
Systemic infection 33.64 9.75 95 292069 9657 79442567
Aspergillus infection 33.63 9.75 14 292150 19147 79433077
White blood cell count decreased 33.34 9.75 487 291677 187801 79264423
Neutropenic sepsis 33.30 9.75 30 292134 27034 79425190
Intestinal villi atrophy 33.29 9.75 21 292143 448 79451776
Infective pulmonary exacerbation of cystic fibrosis 33.22 9.75 4 292160 12847 79439377
Haematotoxicity 33.17 9.75 8 292156 15511 79436713
Dry skin 33.07 9.75 388 291776 67607 79384617
Pulmonary valve disease 32.98 9.75 18 292146 290 79451934
Renal injury 32.82 9.75 136 292028 16791 79435433
Disorientation 32.22 9.75 362 291802 62414 79389810
Rotator cuff syndrome 31.99 9.75 119 292045 13976 79438248
Bronchomalacia 31.93 9.75 17 292147 260 79451964
Cataract 31.79 9.75 358 291806 61762 79390462
Actinic keratosis 31.59 9.75 69 292095 5973 79446251
Anxiety 31.54 9.75 1160 291004 247352 79204872
Feeling abnormal 31.51 9.75 785 291379 158414 79293810
Atrioventricular block 31.42 9.75 118 292046 13923 79438301
Transplant rejection 31.33 9.75 16 292148 19421 79432803
Pericardial disease 31.31 9.75 22 292142 565 79451659
Heart rate increased 31.07 9.75 618 291546 120106 79332118
Fear 31.06 9.75 161 292003 21825 79430399
Gastrointestinal disorder 30.96 9.75 292 291872 121913 79330311
Product prescribing error 30.53 9.75 274 291890 44539 79407685
Granulomatous pneumonitis 30.24 9.75 12 292152 88 79452136
Premature delivery 30.10 9.75 25 292139 23442 79428782
Therapy partial responder 30.08 9.75 13 292151 17384 79434840
Epilepsy 29.66 9.75 66 292098 40794 79411430
Abdominal discomfort 29.27 9.75 697 291467 250030 79202194
Nasopharyngitis 29.02 9.75 708 291456 253173 79199051
Cardiac disorder 28.84 9.75 368 291796 65389 79386835
Large intestine polyp 28.60 9.75 107 292057 12601 79439623
Disturbance in attention 28.41 9.75 298 291866 50503 79401721
Overdose 28.40 9.75 489 291675 183717 79268507
Cytopenia 28.33 9.75 20 292144 20363 79431861
Essential hypertension 28.16 9.75 66 292098 5987 79446237
Mucosal inflammation 28.08 9.75 162 292002 75418 79376806
Photosensitivity reaction 27.99 9.75 152 292012 20975 79431249
Immune reconstitution inflammatory syndrome 27.94 9.75 8 292156 13833 79438391
Hypertensive heart disease 27.88 9.75 53 292111 4153 79448071
Mental status changes 27.81 9.75 371 291793 66588 79385636
Aggression 27.53 9.75 95 292069 50863 79401361
Venoocclusive liver disease 27.36 9.75 5 292159 11766 79440458
Vertigo 27.15 9.75 379 291785 68703 79383521
Kidney transplant rejection 26.96 9.75 3 292161 10243 79441981
Ventricular extrasystoles 26.95 9.75 143 292021 19561 79432663
Gout 26.91 9.75 169 291995 24580 79427644
Weight decreased 26.88 9.75 1574 290590 353624 79098600
Prescribed overdose 26.84 9.75 62 292102 37821 79414403
Pernicious anaemia 26.48 9.75 20 292144 576 79451648
Polydipsia 26.46 9.75 68 292096 6537 79445687
Muscular weakness 26.24 9.75 773 291391 159956 79292268
Macular degeneration 26.17 9.75 96 292068 11200 79441024
Respiratory depression 26.00 9.75 38 292126 27592 79424632
Left ventricular hypertrophy 25.83 9.75 95 292069 11096 79441128
Cutaneous T-cell lymphoma 25.75 9.75 40 292124 2663 79449561
Toxic epidermal necrolysis 25.54 9.75 81 292083 44500 79407724
Interstitial granulomatous dermatitis 25.52 9.75 14 292150 228 79451996
Fluid intake reduced 25.46 9.75 65 292099 6223 79446001
Hypogammaglobulinaemia 25.21 9.75 8 292156 12943 79439281
Basal cell carcinoma 25.19 9.75 228 291936 37147 79415077
Mydriasis 24.94 9.75 17 292147 17626 79434598
Physical examination abnormal 24.89 9.75 15 292149 294 79451930
Visual impairment 24.85 9.75 475 291689 91656 79360568
Tendon rupture 24.76 9.75 99 292065 12027 79440197
Erectile dysfunction 24.75 9.75 113 292051 14551 79437673
Electrocardiogram ST segment depression 24.70 9.75 55 292109 4823 79447401
Peripheral vascular disorder 24.61 9.75 75 292089 7955 79444269
Microalbuminuria 24.58 9.75 23 292141 895 79451329
Device related thrombosis 24.58 9.75 39 292125 2644 79449580
Gastric disorder 24.55 9.75 227 291937 37206 79415018
Schizophrenia 24.46 9.75 13 292151 15427 79436797
Drug-induced liver injury 24.41 9.75 142 292022 65975 79386249
Extrasystoles 24.36 9.75 71 292093 7348 79444876
Vascular purpura 24.31 9.75 42 292122 3056 79449168
Pleural effusion 24.24 9.75 380 291784 144882 79307342
Low density lipoprotein decreased 24.23 9.75 26 292138 1195 79451029
Bone erosion 24.17 9.75 18 292146 17829 79434395
Thrombotic microangiopathy 24.05 9.75 23 292141 20146 79432078
Electrocardiogram abnormal 23.94 9.75 123 292041 16614 79435610
Blood pressure decreased 23.89 9.75 504 291660 98962 79353262
Device related infection 23.60 9.75 57 292107 34237 79417987
Anti-neutrophil cytoplasmic antibody positive vasculitis 23.51 9.75 46 292118 3683 79448541
Autoimmune disorder 23.49 9.75 16 292148 16596 79435628
Drug hypersensitivity 23.42 9.75 877 291287 298039 79154185
Distributive shock 23.17 9.75 38 292126 2649 79449575
Hyperammonaemia 23.17 9.75 6 292158 11087 79441137
Diverticulum 23.10 9.75 112 292052 14784 79437440
Tricuspid valve incompetence 22.94 9.75 137 292027 19575 79432649
Depressed level of consciousness 22.78 9.75 235 291929 96417 79355807
Myelodysplastic syndrome 22.78 9.75 48 292116 30253 79421971
Dilatation atrial 22.52 9.75 45 292119 3659 79448565
Bladder prolapse 22.25 9.75 27 292137 1420 79450804
Blood creatine phosphokinase increased 22.23 9.75 353 291811 65737 79386487
Myalgia 22.22 9.75 861 291303 184780 79267444
Atrioventricular block second degree 22.13 9.75 68 292096 7244 79444980
Myopathy 22.10 9.75 140 292024 20423 79431801
Facet joint syndrome 21.97 9.75 7 292157 11295 79440929
Dysgeusia 21.79 9.75 312 291852 56865 79395359
Lymphopenia 21.66 9.75 50 292114 30507 79421717
Occult blood 21.53 9.75 29 292135 1694 79450530
Lacunar infarction 21.50 9.75 59 292105 5898 79446326
Non-cardiogenic pulmonary oedema 21.49 9.75 27 292137 1472 79450752
Gangrene 21.46 9.75 77 292087 8887 79443337
Musculoskeletal stiffness 21.39 9.75 483 291681 174525 79277699
Orthostatic hypotension 21.22 9.75 306 291858 55858 79396366
Liver function test increased 20.91 9.75 75 292089 39698 79412526
Pancreatitis necrotising 20.85 9.75 45 292119 3863 79448361
Coronary artery occlusion 20.84 9.75 111 292053 15204 79437020
Bundle branch block right 20.73 9.75 89 292075 11162 79441062
Neurosensory hypoacusis 20.72 9.75 12 292152 218 79452006
Grip strength decreased 20.66 9.75 30 292134 21839 79430385
Low density lipoprotein increased 20.59 9.75 74 292090 8548 79443676
Intentional overdose 20.56 9.75 269 291895 105691 79346533
Cardiac murmur 20.39 9.75 113 292051 15711 79436513
Angle closure glaucoma 20.35 9.75 38 292126 2938 79449286
Renal tubular necrosis 20.19 9.75 159 292005 24880 79427344
Hepatic steatosis 20.00 9.75 219 291945 37519 79414705
Multiple-drug resistance 19.92 9.75 4 292160 8804 79443420
Breast cancer stage II 19.87 9.75 3 292161 8117 79444107
Osteonecrosis of jaw 19.87 9.75 86 292078 43140 79409084
Intervertebral disc degeneration 19.86 9.75 112 292052 15673 79436551
Acute coronary syndrome 19.77 9.75 139 292025 20994 79431230
Lung disorder 19.76 9.75 194 291970 80363 79371861
Sinusitis 19.74 9.75 555 291609 194946 79257278
Diverticulitis 19.69 9.75 256 291908 45680 79406544
Nervousness 19.63 9.75 198 291966 33217 79419007
Substance abuse 19.62 9.75 7 292157 10519 79441705
Acquired acrodermatitis enteropathica 19.62 9.75 5 292159 5 79452219
Endometrial cancer stage I 19.58 9.75 11 292153 188 79452036
Aplastic anaemia 19.57 9.75 22 292142 17883 79434341
Colorectal cancer 19.40 9.75 4 292160 8643 79443581
Adverse drug reaction 19.32 9.75 153 292011 66239 79385985
Renal artery stent placement 19.25 9.75 8 292156 67 79452157
Polyuria 19.21 9.75 107 292057 14907 79437317
Muscle spasms 19.19 9.75 803 291361 173927 79278297
Vaginal flatulence 19.02 9.75 34 292130 2541 79449683
Peritonitis 18.98 9.75 47 292117 27989 79424235
Coronary artery bypass 18.94 9.75 57 292107 6005 79446219
Gouty arthritis 18.89 9.75 25 292139 1436 79450788
Chronic sinusitis 18.82 9.75 96 292068 12930 79439294
Tooth erosion 18.81 9.75 14 292150 394 79451830
Disability 18.75 9.75 21 292143 17099 79435125
Pathogen resistance 18.74 9.75 15 292149 14327 79437897
Progressive multifocal leukoencephalopathy 18.74 9.75 29 292135 20571 79431653
Memory impairment 18.68 9.75 539 291625 111195 79341029
Poisoning deliberate 18.61 9.75 25 292139 18803 79433421
Vulvovaginal burning sensation 18.38 9.75 26 292138 1591 79450633
Respiratory tract inflammation 18.14 9.75 19 292145 849 79451375
Erythrodermic psoriasis 18.14 9.75 27 292137 1731 79450493
Agranulocytosis 18.11 9.75 94 292070 44936 79407288
Diastolic dysfunction 18.01 9.75 83 292081 10728 79441496
Heart rate irregular 17.94 9.75 191 291973 32488 79419736
Hip fracture 17.94 9.75 182 291982 30579 79421645
Meniere's disease 17.85 9.75 10 292154 170 79452054
Meniscus injury 17.82 9.75 60 292104 6708 79445516
Fear of injection 17.75 9.75 3 292161 7471 79444753
Adenocarcinoma 17.67 9.75 42 292122 3844 79448380
Pharyngeal oedema 17.62 9.75 111 292053 16161 79436063
Foetal death 17.48 9.75 4 292160 8040 79444184
Polymyalgia rheumatica 17.45 9.75 46 292118 4491 79447733
Oropharyngeal swelling 17.43 9.75 23 292141 1317 79450907
Muscle necrosis 17.40 9.75 24 292140 1434 79450790
Respiratory failure 17.40 9.75 517 291647 180394 79271830
Multiple drug therapy 17.40 9.75 43 292121 4035 79448189
Withdrawal hypertension 17.31 9.75 13 292151 371 79451853
Pollakiuria 17.29 9.75 211 291953 37106 79415118
Cystitis haemorrhagic 17.27 9.75 6 292158 9166 79443058
Metastases to fallopian tube 17.22 9.75 7 292157 55 79452169
Depression 17.21 9.75 965 291199 215825 79236399
Polyp 17.21 9.75 67 292097 8040 79444184
Rhinovirus infection 17.20 9.75 4 292160 7949 79444275
Choroidal detachment 17.16 9.75 16 292148 620 79451604
Breast neoplasm 17.03 9.75 19 292145 913 79451311
Device expulsion 17.00 9.75 44 292120 25817 79426407
Uveitis 16.99 9.75 22 292142 16808 79435416
Torsade de pointes 16.90 9.75 125 292039 19187 79433037
Blood creatine increased 16.81 9.75 74 292090 9381 79442843
Paradoxical drug reaction 16.81 9.75 3 292161 7182 79445042
Renovascular hypertension 16.80 9.75 7 292157 59 79452165
Enterocolitis 16.79 9.75 17 292147 14495 79437729
Joint range of motion decreased 16.69 9.75 64 292100 33218 79419006
Hepatic neoplasm 16.65 9.75 38 292126 3388 79448836
Miosis 16.61 9.75 20 292144 15769 79436455
Peripheral swelling 16.52 9.75 813 291351 268804 79183420
Cutaneous lupus erythematosus 16.51 9.75 35 292129 2968 79449256
Aortic valve incompetence 16.50 9.75 74 292090 9456 79442768
Hypertensive angiopathy 16.45 9.75 8 292156 100 79452124
Lower limb fracture 16.44 9.75 38 292126 23177 79429047
Thalamic infarction 16.34 9.75 22 292142 1285 79450939
Tumour lysis syndrome 16.31 9.75 40 292124 23899 79428325
Osteoarthritis 16.23 9.75 427 291737 86882 79365342
Crystal arthropathy 16.20 9.75 10 292154 205 79452019
Product quality issue 16.20 9.75 193 291971 33747 79418477
Hemiparesis 16.18 9.75 192 291972 33541 79418683
Injection site inflammation 16.00 9.75 41 292123 3935 79448289
Gait disturbance 15.95 9.75 921 291243 206585 79245639
Blood lactic acid decreased 15.91 9.75 11 292153 275 79451949
Rhinalgia 15.91 9.75 30 292134 2337 79449887
Mandibular mass 15.91 9.75 10 292154 212 79452012
Lichen planus 15.89 9.75 33 292131 2758 79449466
Neurofibrosarcoma 15.82 9.75 10 292154 214 79452010
Osteogenesis imperfecta 15.81 9.75 14 292150 507 79451717
Allergic cough 15.80 9.75 16 292148 687 79451537
Vascular device infection 15.77 9.75 9 292155 10267 79441957
Delirium 15.63 9.75 217 291947 84410 79367814
Clostridium difficile infection 15.58 9.75 92 292072 42593 79409631
Blood triglycerides increased 15.56 9.75 131 292033 20909 79431315
Cell death 15.45 9.75 45 292119 4654 79447570
Nephrocalcinosis 15.40 9.75 23 292141 1479 79450745
Tooth abscess 15.39 9.75 107 292057 16103 79436121
Shoshin beriberi 15.34 9.75 7 292157 75 79452149
Ascites 15.33 9.75 190 291974 75372 79376852
Enterococcal infection 15.27 9.75 21 292143 15639 79436585
Endometrial hyperplasia 15.26 9.75 15 292149 621 79451603
Psychotic disorder 15.24 9.75 89 292075 41313 79410911
Mucosal membrane hyperplasia 15.24 9.75 6 292158 43 79452181
Accidental exposure to product 15.21 9.75 61 292103 31261 79420963
Adverse event 15.19 9.75 144 292020 60070 79392154
Pruritus allergic 15.18 9.75 22 292142 1377 79450847
Rectal prolapse 15.13 9.75 28 292136 2150 79450074
Renin increased 15.04 9.75 10 292154 234 79451990
Pseudomonas infection 14.98 9.75 34 292130 20869 79431355
Heart rate decreased 14.89 9.75 350 291814 69966 79382258
Knee arthroplasty 14.86 9.75 95 292069 43153 79409071
Chronic kidney disease 14.85 9.75 332 291832 65822 79386402
Akathisia 14.81 9.75 16 292148 13243 79438981
Nodular rash 14.77 9.75 11 292153 310 79451914
Renal artery angioplasty 14.71 9.75 5 292159 22 79452202
Renal function test abnormal 14.68 9.75 46 292118 4952 79447272
Carpal tunnel syndrome 14.66 9.75 122 292042 19406 79432818
Jaw disorder 14.64 9.75 46 292118 4960 79447264
Agitation 14.63 9.75 267 291897 99448 79352776
Shock hypoglycaemic 14.57 9.75 10 292154 247 79451977
Seizure 14.56 9.75 555 291609 188279 79263945
Blood osmolarity decreased 14.54 9.75 21 292143 1310 79450914
Carcinoid tumour of the gastrointestinal tract 14.43 9.75 7 292157 87 79452137
Lipohypertrophy 14.43 9.75 17 292147 867 79451357
Blood hyposmosis 14.36 9.75 5 292159 24 79452200
Cholelithiasis 14.36 9.75 272 291892 52392 79399832
Depressive symptom 14.35 9.75 3 292161 6420 79445804
Insomnia 14.31 9.75 1063 291101 244107 79208117
Trigger finger 14.30 9.75 41 292123 4204 79448020
Electrocardiogram U-wave abnormality 14.29 9.75 7 292157 89 79452135
Cardiovascular disorder 14.28 9.75 114 292050 17911 79434313
Febrile bone marrow aplasia 14.23 9.75 16 292148 13004 79439220
Alkalosis hypochloraemic 14.22 9.75 13 292151 491 79451733
Hyponatraemic encephalopathy 14.21 9.75 11 292153 329 79451895
Gastrointestinal toxicity 14.11 9.75 6 292158 8103 79444121
Accelerated hypertension 14.02 9.75 15 292149 687 79451537
Spinal osteoarthritis 13.93 9.75 108 292056 16819 79435405
Adjustment disorder with depressed mood 13.88 9.75 8 292156 9078 79443146
Lymphomatoid papulosis 13.84 9.75 11 292153 342 79451882
Skin exfoliation 13.82 9.75 281 291883 54819 79397405
Angiopathy 13.81 9.75 57 292107 7025 79445199
Preternatural anus 13.69 9.75 7 292157 98 79452126
Vulvovaginal pruritus 13.69 9.75 30 292134 2603 79449621
Anaphylactic reaction 13.65 9.75 220 291944 83523 79368701
Device dislocation 13.63 9.75 49 292115 25921 79426303
Squamous cell carcinoma 13.60 9.75 101 292063 15521 79436703
Cardiac discomfort 13.60 9.75 20 292144 1268 79450956
Intervertebral disc displacement 13.49 9.75 12 292152 437 79451787
Aspiration 13.48 9.75 34 292130 20124 79432100
Dementia 13.48 9.75 144 292020 24515 79427709
Blood lactate dehydrogenase increased 13.48 9.75 86 292078 39084 79413140
Eosinophilia myalgia syndrome 13.48 9.75 4 292160 10 79452214
Herpes zoster 13.42 9.75 250 291914 92833 79359391
Recalled product 13.39 9.75 17 292147 937 79451287
Ventricular arrhythmia 13.37 9.75 66 292098 8774 79443450
Gastrointestinal angiodysplasia 13.37 9.75 18 292146 1051 79451173
Laryngeal pain 13.36 9.75 51 292113 6063 79446161
Hepatitis B reactivation 13.35 9.75 3 292161 6105 79446119
Eosinophilia 13.34 9.75 237 291927 45108 79407116
Body temperature decreased 13.30 9.75 178 291986 31967 79420257
Appendicitis 13.20 9.75 36 292128 20758 79431466
Plasma cell myeloma 13.17 9.75 128 292036 53131 79399093
Suicide attempt 13.15 9.75 219 291945 82713 79369511
Inappropriate schedule of product administration 13.07 9.75 381 291783 133247 79318977
Lymphangiectasia intestinal 12.95 9.75 4 292160 12 79452212
Renal artery restenosis 12.95 9.75 4 292160 12 79452212
Body height decreased 12.94 9.75 64 292100 8516 79443708
High density lipoprotein decreased 12.91 9.75 42 292122 4613 79447611
COVID-19 pneumonia 12.89 9.75 58 292106 28791 79423433
Mouth ulceration 12.85 9.75 85 292079 38309 79413915
Paraesthesia oral 12.85 9.75 123 292041 20348 79431876
Bacterial sepsis 12.84 9.75 7 292157 8191 79444033
Cytomegalovirus test positive 12.84 9.75 3 292161 5944 79446280
Helicobacter gastritis 12.84 9.75 28 292136 2421 79449803
Oesophageal carcinoma 12.80 9.75 13 292151 11071 79441153
International normalised ratio decreased 12.75 9.75 61 292103 8009 79444215
Rheumatoid factor 12.73 9.75 11 292153 385 79451839
Exposure to toxic agent 12.71 9.75 9 292155 9149 79443075
Carotid bruit 12.68 9.75 15 292149 768 79451456
Haemolysis 12.68 9.75 17 292147 12795 79439429
Azotaemia 12.67 9.75 62 292102 8214 79444010
Acute myopia 12.60 9.75 7 292157 117 79452107
Circumoral oedema 12.58 9.75 10 292154 311 79451913
Diabetes mellitus 12.51 9.75 376 291788 78014 79374210
Dysuria 12.50 9.75 259 291905 50692 79401532
Renin decreased 12.49 9.75 7 292157 119 79452105
Diabetes mellitus inadequate control 12.48 9.75 140 292024 24124 79428100
Troponin I increased 12.47 9.75 42 292122 4696 79447528
Injury 12.45 9.75 372 291792 77124 79375100
Retroperitoneal fibrosis 12.44 9.75 14 292150 679 79451545
X-ray abnormal 12.42 9.75 3 292161 5810 79446414
Peripheral circulatory failure 12.40 9.75 18 292146 1128 79451096
Small cell carcinoma 12.39 9.75 10 292154 318 79451906
Incorrect route of product administration 12.37 9.75 76 292088 34853 79417371
Pneumatosis intestinalis 12.37 9.75 4 292160 6393 79445831
Neoplasm 12.36 9.75 66 292098 9050 79443174
Hypoxia 12.31 9.75 286 291878 102957 79349267
Echocardiogram abnormal 12.28 9.75 26 292138 2202 79450022
Nephropathy 12.19 9.75 69 292095 9669 79442555
Asphyxia 12.17 9.75 15 292149 11705 79440519
Paresis cranial nerve 12.12 9.75 5 292159 41 79452183
Pathological fracture 12.11 9.75 73 292091 10464 79441760
Wrong technique in product usage process 12.07 9.75 194 291970 73681 79378543
Acute hepatic failure 12.03 9.75 63 292101 30050 79422174
Fibrous histiocytoma 12.02 9.75 14 292150 705 79451519
Allergic hepatitis 12.02 9.75 5 292159 42 79452182
Post-anoxic myoclonus 12.02 9.75 5 292159 42 79452182
Premature labour 11.97 9.75 8 292156 8382 79443842
Hyperglycaemia 11.95 9.75 340 291824 69995 79382229
Carcinogenicity 11.93 9.75 6 292158 81 79452143
Cerebral ischaemia 11.89 9.75 76 292088 11119 79441105
Coordination abnormal 11.87 9.75 106 292058 17206 79435018
Haemodialysis 11.82 9.75 110 292054 18058 79434166
Hemiataxia 11.81 9.75 5 292159 44 79452180
Metabolic syndrome 11.80 9.75 29 292135 2711 79449513
Pneumothorax spontaneous 11.79 9.75 20 292144 1434 79450790
Electrocardiogram Q wave abnormal 11.78 9.75 13 292151 617 79451607
Renal artery dissection 11.77 9.75 3 292161 3 79452221
Homans' sign 11.77 9.75 3 292161 3 79452221
Urinary incontinence 11.75 9.75 213 291951 40696 79411528
Coronary artery restenosis 11.74 9.75 19 292145 1310 79450914
Klebsiella infection 11.73 9.75 25 292139 15695 79436529
CD4/CD8 ratio increased 11.70 9.75 4 292160 18 79452206
Hypocalcaemia 11.67 9.75 252 291912 49672 79402552
Vestibular neuronitis 11.65 9.75 14 292150 729 79451495
Cyanopsia 11.61 9.75 6 292158 86 79452138
Coronary artery stenosis 11.61 9.75 82 292082 12402 79439822
Non-cardiac chest pain 11.61 9.75 67 292097 9457 79442767
Intervertebral disc protrusion 11.57 9.75 135 292029 23486 79428738
Electrocardiogram T wave amplitude decreased 11.54 9.75 14 292150 736 79451488
Pulmonary alveolar haemorrhage 11.54 9.75 15 292149 11442 79440782
Cardiac arrest 11.52 9.75 514 291650 171582 79280642
Osteitis deformans 11.50 9.75 8 292156 202 79452022
Hepatojugular reflux 11.48 9.75 13 292151 635 79451589
Renal artery arteriosclerosis 11.44 9.75 5 292159 48 79452176
Nail bed inflammation 11.43 9.75 12 292152 538 79451686
Drug use disorder 11.37 9.75 9 292155 8642 79443582
Staphylococcal sepsis 11.34 9.75 23 292141 14703 79437521
Electrocardiogram Q waves 11.31 9.75 6 292158 91 79452133
Device use error 11.22 9.75 6 292158 7095 79445129
Vitamin B1 decreased 11.19 9.75 12 292152 551 79451673
Haemorrhagic stroke 11.13 9.75 74 292090 10972 79441252
Dysarthria 10.97 9.75 325 291839 67297 79384927
Atrophy 10.89 9.75 24 292140 2090 79450134
Inflammatory marker increased 10.88 9.75 14 292150 10726 79441498
Neuroglycopenia 10.85 9.75 11 292153 473 79451751
Gastrointestinal mucosal necrosis 10.85 9.75 8 292156 222 79452002
Hepatotoxicity 10.85 9.75 128 292036 51224 79401000
Back pain 10.82 9.75 1273 290891 302907 79149317
Hypervitaminosis D 10.81 9.75 6 292158 100 79452124
Nodal arrhythmia 10.81 9.75 23 292141 1955 79450269
Ischaemic stroke 10.78 9.75 176 291988 32955 79419269
Diverticulum oesophageal 10.75 9.75 7 292157 158 79452066
Type V hyperlipidaemia 10.73 9.75 16 292148 1027 79451197
Radiculopathy 10.70 9.75 62 292102 8762 79443462
Abdominal tenderness 10.69 9.75 71 292093 10523 79441701
Hepatocellular injury 10.69 9.75 117 292047 47476 79404748
Thirst decreased 10.69 9.75 9 292155 304 79451920
Adiposis dolorosa 10.69 9.75 9 292155 304 79451920
Swelling face 10.68 9.75 339 291825 70873 79381351
Cachexia 10.67 9.75 15 292149 11068 79441156
Aortic stenosis 10.67 9.75 55 292109 7440 79444784
Onychomadesis 10.64 9.75 3 292161 5239 79446985
Hypersensitivity vasculitis 10.62 9.75 52 292112 6891 79445333
Supraventricular tachycardia 10.62 9.75 122 292042 21148 79431076
Confabulation 10.59 9.75 11 292153 487 79451737
Cardiac stress test abnormal 10.58 9.75 14 292150 804 79451420
Depressed mood 10.57 9.75 120 292044 48360 79403864
Pulmonary tuberculosis 10.56 9.75 8 292156 7857 79444367
Diabetic neuropathy 10.56 9.75 48 292116 6168 79446056
Pulpitis dental 10.56 9.75 18 292146 1295 79450929
Colitis 10.53 9.75 197 291967 73110 79379114
Device occlusion 10.51 9.75 17 292147 11849 79440375
Peripheral venous disease 10.51 9.75 27 292137 15882 79436342
Aplasia 10.45 9.75 8 292156 7812 79444412
Forced vital capacity decreased 10.39 9.75 21 292143 1722 79450502
Staring 10.36 9.75 27 292137 2618 79449606
Pseudolymphoma 10.34 9.75 17 292147 1188 79451036
Electrocardiogram ST-T change 10.33 9.75 20 292144 1589 79450635
Parotitis 10.33 9.75 26 292138 2468 79449756
Endometrial disorder 10.29 9.75 12 292152 605 79451619
Carotid arteriosclerosis 10.29 9.75 27 292137 2629 79449595
Neuroleptic malignant syndrome 10.27 9.75 59 292105 27500 79424724
Shock 10.24 9.75 220 291944 43328 79408896
Renal arteriosclerosis 10.23 9.75 9 292155 323 79451901
Parainfluenzae virus infection 10.22 9.75 4 292160 5678 79446546
Product commingling 10.21 9.75 6 292158 112 79452112
Spinal cord infarction 10.20 9.75 12 292152 611 79451613
Oesophageal discomfort 10.18 9.75 9 292155 325 79451899
Bladder irrigation 10.18 9.75 5 292159 64 79452160
Transaminases increased 10.17 9.75 131 292033 51612 79400612
Sleep apnoea syndrome 10.15 9.75 189 291975 36289 79415935
Blood growth hormone increased 10.15 9.75 13 292151 723 79451501
Hypoparathyroidism 10.11 9.75 16 292148 1082 79451142
Aortic valve sclerosis 10.08 9.75 21 292143 1759 79450465
QRS axis abnormal 10.07 9.75 23 292141 2051 79450173
Encephalopathy 10.03 9.75 180 291984 67217 79385007
Glomerulonephritis rapidly progressive 9.99 9.75 20 292144 1628 79450596
Gastrointestinal perforation 9.97 9.75 5 292159 6132 79446092
Haemarthrosis 9.97 9.75 45 292119 5767 79446457
Immunosuppressant drug level increased 9.97 9.75 11 292153 9016 79443208
Ischaemic cardiomyopathy 9.95 9.75 55 292109 7640 79444584
Macrocytosis 9.94 9.75 28 292136 2842 79449382
Mitral valve disease 9.93 9.75 30 292134 3167 79449057
Product residue present 9.89 9.75 32 292132 3504 79448720
Haemorrhagic fever 9.89 9.75 4 292160 31 79452193
Immunosuppression 9.86 9.75 20 292144 12783 79439441
Pneumothorax 9.84 9.75 62 292102 28261 79423963
Product administered to patient of inappropriate age 9.84 9.75 4 292160 5549 79446675
Night sweats 9.83 9.75 133 292031 51962 79400262
Encephalitis 9.79 9.75 25 292139 14735 79437489
Activated partial thromboplastin time 9.78 9.75 4 292160 32 79452192
Coronary arterial stent insertion 9.78 9.75 46 292118 5998 79446226
Wound treatment 9.76 9.75 7 292157 186 79452038
Normal newborn 9.75 9.75 7 292157 7065 79445159

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03AA03 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, plain
ATC C03AB03 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides and potassium in combination
ATC C03AX01 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, combinations with other drugs
ATC C03EA01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Low-ceiling diuretics and potassium-sparing agents
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09DX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX08 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09XA52 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C09XA54 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
FDA CS M0471776 Thiazides
FDA PE N0000175359 Increased Diuresis
FDA EPC N0000175419 Thiazide Diuretic
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049993 Sodium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35498 diuretics
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Edema indication 267038008
Hypertensive urgency indication 443482000
Pulmonary Edema due to Chronic Heart Failure indication
Peripheral Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Hypertension with Left Ventricular Hypertrophy indication
Edema due to Nephrotic Syndrome indication
Nephrogenic diabetes insipidus off-label use 111395007 DOID:12387
Calcium renal calculus off-label use 427649000
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Suicidal thoughts contraindication 6471006
Psoriasis contraindication 9014002 DOID:8893
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Chronic disease of respiratory system contraindication 17097001
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Jaundice contraindication 18165001
Cirrhosis of liver contraindication 19943007 DOID:5082
Secondary angle-closure glaucoma contraindication 21571006
Electroconvulsive therapy contraindication 23835007
Acute vomiting contraindication 23971007
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Obstruction of bile duct contraindication 30144000
Parkinsonism contraindication 32798002
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Acute hepatitis contraindication 37871000
Immunosuppression contraindication 38013005
Anaphylaxis contraindication 39579001
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Sinus bradycardia contraindication 49710005
Cough contraindication 49727002
Acidosis contraindication 51387008
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Aortic valve stenosis contraindication 60573004 DOID:1712
Chronic bronchitis contraindication 63480004 DOID:6132
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Benign intracranial hypertension contraindication 68267002 DOID:11459
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Oliguria contraindication 83128009
Epilepsy contraindication 84757009 DOID:1826
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Kidney stone contraindication 95570007
Disorder of connective tissue contraindication 105969002 DOID:65
Diabetic renal disease contraindication 127013003
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Asthma contraindication 195967001 DOID:2841
Acute hepatic failure contraindication 197270009
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Disorder of electrolytes contraindication 237840007
Lupus erythematosus and erythema multiforme-like syndrome contraindication 238926009
Rhabdomyolysis contraindication 240131006
Raynaud's phenomenon contraindication 266261006
Calculus in biliary tract contraindication 266474003
Anemia contraindication 271737000 DOID:2355
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Pheochromocytoma contraindication 302835009
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Severe chronic obstructive pulmonary disease contraindication 313299006
Right ventricular failure contraindication 367363000
Surgical procedure contraindication 387713003
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Severe diarrhea contraindication 409587002
Autoimmune hemolytic anemia contraindication 413603009 DOID:718
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Porphyria contraindication 418470004
Intraoperative floppy iris syndrome contraindication 418801006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
First Degree Atrioventricular Heart Block contraindication
Intestinal Angioedema contraindication
Severe Aortic Valve Stenosis contraindication
Hemodialysis with High-Flux Membrane contraindication
Head and Neck Angioedema contraindication
Severe Cerebrovascular Disease contraindication




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cattle Postparturient udder edema Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Hydrozide Injection Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.89 acidic
pKa2 11.02 acidic
pKa3 0.71 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 3 Transporter INHIBITOR A2 7.01 WOMBAT-PK CHEMBL
Carbonic anhydrase 1 Enzyme Ki 6.48 CHEMBL
Carbonic anhydrase 4 Enzyme WOMBAT-PK
Calcium-activated potassium channel subunit alpha-1 Ion channel WOMBAT-PK
Carbonic anhydrase 2 Enzyme Ki 5.90 WOMBAT-PK
Astrosclerin-3 Enzyme Ki 6.40 CHEMBL
Delta carbonic anhydrase Unclassified Ki 5.37 CHEMBL
Carbonic anhydrase Enzyme Ki 7.50 CHEMBL
Carbonic anhydrase, alpha family Unclassified Ki 6.53 CHEMBL
Carbonate dehydratase Enzyme Ki 8.14 CHEMBL

External reference:

IDSource
4017615 VUID
N0000145995 NUI
D00340 KEGG_DRUG
4017615 VANDF
C0020261 UMLSCUI
CHEBI:5778 CHEBI
HCZ PDB_CHEM_ID
CHEMBL435 ChEMBL_ID
CHEMBL43686 ChEMBL_ID
CHEMBL15605 ChEMBL_ID
DB00999 DRUGBANK_ID
D006852 MESH_DESCRIPTOR_UI
3639 PUBCHEM_CID
4836 IUPHAR_LIGAND_ID
841 INN_ID
0J48LPH2TH UNII
5487 RXNORM
4834 MMSL
924 MMSL
d00253 MMSL
002294 NDDF
387525002 SNOMEDCT_US
91667005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5855 TABLET, FILM COATED 12.50 mg ORAL NDA 30 sections
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5855 TABLET, FILM COATED 12.50 mg ORAL NDA 30 sections
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5856 TABLET, FILM COATED 12.50 mg ORAL NDA 30 sections
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5856 TABLET, FILM COATED 12.50 mg ORAL NDA 30 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1011 TABLET, FILM COATED 25 mg ORAL NDA 24 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1011 TABLET, FILM COATED 25 mg ORAL NDA 24 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1021 TABLET, FILM COATED 50 mg ORAL NDA 24 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1021 TABLET, FILM COATED 50 mg ORAL NDA 24 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0254 TABLET 12.50 mg ORAL ANDA 28 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0255 TABLET 12.50 mg ORAL ANDA 28 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0545 TABLET 12.50 mg ORAL NDA authorized generic 27 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0546 TABLET 12.50 mg ORAL NDA authorized generic 27 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0547 TABLET 25 mg ORAL NDA authorized generic 27 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-0220 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-0222 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-0223 TABLET, FILM COATED 25 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-0223 TABLET, FILM COATED 25 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-3112 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-3112 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-5212 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-5212 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-7225 TABLET, FILM COATED 25 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-7225 TABLET, FILM COATED 25 mg ORAL NDA 22 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0314 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0314 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0314 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0315 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0315 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0315 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0383 TABLET, FILM COATED 25 mg ORAL NDA 31 sections