hydrochlorothiazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 1385 58-93-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrochlorothiazide
  • hydrochlorothiazid
  • hydrochlorthiazide
  • hydrochlorzide
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
  • Molecular weight: 297.73
  • Formula: C7H8ClN3O4S2
  • CLOGP: -0.36
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -2.12
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
25 mg O
25 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.60 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 100 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.18 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Feb. 12, 1959 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1143.45 9.57 1684 218255 100455 55971673
Pemphigus 548.13 9.57 14 219925 157198 55914930
Hypokalaemia 506.16 9.57 1131 218808 93306 55978822
Maternal exposure during pregnancy 466.12 9.57 88 219851 189465 55882663
Systemic lupus erythematosus 421.22 9.57 94 219845 179984 55892144
Hand deformity 418.89 9.57 27 219912 134465 55937663
Glossodynia 382.91 9.57 67 219872 152391 55919737
Pericarditis 347.88 9.57 19 219920 108904 55963224
Off label use 336.48 9.57 1086 218853 555094 55517034
Contraindicated product administered 321.66 9.57 163 219776 186123 55886005
Acute kidney injury 303.31 9.57 1789 218150 238974 55833154
Synovitis 301.98 9.57 126 219813 161179 55910949
Rheumatoid arthritis 301.01 9.57 655 219284 381949 55690179
Blood pressure increased 282.54 9.57 1220 218719 143956 55928172
Treatment failure 265.60 9.57 169 219770 170223 55901905
Duodenal ulcer perforation 242.29 9.57 5 219934 68337 56003791
Blood potassium decreased 241.38 9.57 493 219446 38179 56033949
Alopecia 237.60 9.57 494 219445 292964 55779164
Exposure during pregnancy 237.24 9.57 118 219821 136224 55935904
Drug intolerance 231.49 9.57 426 219513 264392 55807736
Wound 224.18 9.57 132 219807 138672 55933456
Cerebrovascular accident 220.41 9.57 869 219070 98401 55973727
Drug ineffective 217.35 9.57 2424 217515 916565 55155563
Arthropathy 211.22 9.57 284 219655 199991 55872137
Hypertension 210.44 9.57 1653 218286 242625 55829503
Lower respiratory tract infection 204.80 9.57 96 219843 114698 55957430
Myocardial infarction 200.56 9.57 806 219133 92064 55980064
Rheumatoid factor positive 185.49 9.57 25 219914 69035 56003093
Discomfort 175.28 9.57 177 219762 141584 55930544
Angioedema 174.05 9.57 452 219487 41001 56031127
Infusion related reaction 165.37 9.57 356 219583 208575 55863553
Dizziness 160.89 9.57 2206 217733 373934 55698194
Abdominal discomfort 160.47 9.57 551 219388 276723 55795405
Dehydration 154.25 9.57 1106 218833 157719 55914409
Coronary artery disease 153.89 9.57 359 219580 30437 56041691
Product use issue 143.08 9.57 322 219617 185719 55886409
Syncope 141.76 9.57 813 219126 107386 55964742
Muscle injury 141.00 9.57 19 219920 52481 56019647
Joint swelling 140.08 9.57 619 219320 289181 55782947
Blood pressure inadequately controlled 139.18 9.57 126 219813 4398 56067730
Sleep disorder due to general medical condition, insomnia type 136.97 9.57 8 219931 43330 56028798
Therapeutic product effect decreased 135.49 9.57 287 219652 169165 55902963
Folliculitis 133.99 9.57 26 219913 54953 56017175
Macular degeneration 129.94 9.57 251 219688 18657 56053471
Eosinophilic bronchitis 125.77 9.57 54 219885 460 56071668
Helicobacter infection 125.01 9.57 65 219874 73203 55998925
Swelling 123.94 9.57 499 219440 239272 55832856
Gastrooesophageal reflux disease 122.04 9.57 645 219294 82612 55989516
Inappropriate antidiuretic hormone secretion 121.90 9.57 204 219735 13552 56058576
Asthenia 119.02 9.57 1941 217998 341032 55731096
Drug abuse 118.32 9.57 58 219881 67552 56004576
Fall 113.75 9.57 1995 217944 355515 55716613
Infection 112.28 9.57 403 219536 199803 55872325
Lactic acidosis 108.15 9.57 344 219595 35002 56037126
Condition aggravated 107.83 9.57 847 219092 344051 55728077
Hepatic enzyme increased 103.55 9.57 334 219605 171050 55901078
Irritable bowel syndrome 99.76 9.57 73 219866 68385 56003743
Blister 99.64 9.57 170 219769 108717 55963411
Hypotension 97.20 9.57 1445 218494 249063 55823065
Abortion spontaneous 94.17 9.57 27 219912 43726 56028402
Pain 92.13 9.57 1935 218004 661249 55410879
Intentional product use issue 90.98 9.57 156 219783 99577 55972551
Oedema peripheral 88.09 9.57 1040 218899 170214 55901914
Blood glucose increased 86.46 9.57 546 219393 74605 55997523
Blood sodium decreased 85.12 9.57 235 219704 22099 56050029
Transient ischaemic attack 82.74 9.57 304 219635 33273 56038855
Renal failure 80.16 9.57 720 219219 109780 55962348
Hypertensive crisis 79.48 9.57 172 219767 13864 56058264
Impaired healing 79.06 9.57 136 219803 86705 55985423
Death 79.06 9.57 903 219036 340523 55731605
Hypochloraemia 78.33 9.57 60 219879 1652 56070476
Cardiac failure congestive 73.89 9.57 591 219348 87129 55984999
Chest pain 73.24 9.57 1094 218845 188703 55883425
Product use in unapproved indication 71.48 9.57 295 219644 140527 55931601
Blood urea increased 71.08 9.57 234 219705 24239 56047889
Intentional self-injury 69.65 9.57 8 219931 24984 56047144
Pregnancy 68.17 9.57 22 219917 33011 56039117
Intentional overdose 67.34 9.57 101 219838 68016 56004112
Rash 67.01 9.57 1443 218496 491604 55580524
Pancreatitis acute 66.61 9.57 233 219706 24891 56047237
Sprue-like enteropathy 66.41 9.57 36 219903 534 56071594
Angina pectoris 65.35 9.57 249 219690 27727 56044401
Toxicity to various agents 63.94 9.57 565 219374 223999 55848129
Live birth 63.89 9.57 3 219936 19602 56052526
Hip arthroplasty 63.34 9.57 36 219903 38587 56033541
Hypovolaemia 62.97 9.57 126 219813 9609 56062519
Stomatitis 62.61 9.57 251 219688 120559 55951569
Hypertensive emergency 61.94 9.57 51 219888 1562 56070566
Lung diffusion test abnormal 61.41 9.57 27 219912 245 56071883
Hypersensitivity 60.93 9.57 674 219265 255734 55816394
Blood creatinine increased 59.94 9.57 526 219413 79665 55992463
Product complaint 59.73 9.57 138 219801 11622 56060506
Palpitations 58.81 9.57 622 219317 99050 55973078
Mobility decreased 57.63 9.57 196 219743 98795 55973333
Red blood cell sedimentation rate abnormal 57.35 9.57 4 219935 18669 56053459
Hyperkalaemia 56.91 9.57 367 219572 50498 56021630
C-reactive protein abnormal 56.61 9.57 37 219902 36772 56035356
Ill-defined disorder 55.65 9.57 115 219824 68428 56003700
Polyp 55.17 9.57 90 219849 5852 56066276
Hypoglycaemia 54.85 9.57 390 219549 55425 56016703
Drug interaction 54.38 9.57 1135 218804 208620 55863508
Therapy non-responder 53.21 9.57 99 219840 61256 56010872
Febrile neutropenia 52.98 9.57 222 219717 105323 55966805
Atrial fibrillation 52.32 9.57 653 219286 108244 55963884
Peripheral swelling 52.25 9.57 626 219313 234100 55838028
Sinus bradycardia 51.81 9.57 143 219796 13443 56058685
Loss of employment 50.10 9.57 49 219890 1888 56070240
Nausea 49.41 9.57 3541 216398 760637 55311491
Blood pressure diastolic decreased 49.34 9.57 177 219762 19146 56052982
Angina unstable 48.65 9.57 92 219847 6729 56065399
Gastrointestinal disorder 48.34 9.57 251 219688 112451 55959677
Cytomegalovirus infection 47.27 9.57 9 219930 19287 56052841
Neutropenia 46.30 9.57 395 219544 157772 55914356
Recalled product 45.36 9.57 40 219899 1348 56070780
Psoriatic arthropathy 44.12 9.57 145 219794 73863 55998265
Cataract 43.53 9.57 346 219593 50901 56021227
Pyrexia 42.23 9.57 1280 218659 417493 55654635
Malignant neoplasm progression 41.28 9.57 148 219791 73439 55998689
Arterial occlusive disease 41.13 9.57 75 219864 5335 56066793
Blood pressure systolic increased 40.51 9.57 286 219653 40550 56031578
Disorientation 40.24 9.57 263 219676 36350 56035778
Drug resistance 40.11 9.57 15 219924 20527 56051601
Pemphigoid 40.10 9.57 81 219858 6219 56065909
Pancreatitis 39.74 9.57 307 219632 44773 56027355
Pneumonia aspiration 39.47 9.57 239 219700 32172 56039956
Diabetes mellitus 39.44 9.57 346 219593 52389 56019739
Swollen tongue 39.10 9.57 227 219712 30097 56042031
Musculoskeletal stiffness 39.06 9.57 405 219534 155602 55916526
Myelosuppression 39.01 9.57 10 219929 17445 56054683
Large intestine polyp 38.19 9.57 89 219850 7538 56064590
Milk-alkali syndrome 37.63 9.57 27 219912 671 56071457
Hepatic function abnormal 37.40 9.57 48 219891 34510 56037618
Premature delivery 36.71 9.57 31 219908 27029 56045099
Neutrophil count decreased 36.03 9.57 89 219850 49733 56022395
Ventricular hypertrophy 35.58 9.57 53 219886 3185 56068943
Allergic oedema 34.71 9.57 27 219912 761 56071367
Hypercalcaemia 34.59 9.57 193 219746 25218 56046910
Disease progression 34.31 9.57 255 219684 104918 55967210
Nasopharyngitis 34.01 9.57 633 219306 220326 55851802
Conjoined twins 33.50 9.57 18 219921 262 56071866
Hospitalisation 33.30 9.57 165 219774 74835 55997293
Weight decreased 33.30 9.57 1201 218738 239513 55832615
Arrhythmia 33.23 9.57 243 219696 34840 56037288
Cough 33.07 9.57 1285 218654 258676 55813452
Hyperlipidaemia 32.73 9.57 149 219790 17960 56054168
Rhabdomyolysis 32.63 9.57 271 219668 40387 56031741
Mitral valve incompetence 32.54 9.57 149 219790 18004 56054124
Sedation complication 31.87 9.57 4 219935 11668 56060460
Blood chloride decreased 31.41 9.57 66 219873 5211 56066917
Feeling abnormal 31.10 9.57 712 219227 132890 55939238
Myalgia 30.85 9.57 704 219235 131321 55940807
Intestinal angioedema 30.57 9.57 23 219916 616 56071512
Acute myeloid leukaemia 30.54 9.57 14 219925 16958 56055170
Neutrophilia 30.50 9.57 55 219884 3878 56068250
Muscle spasms 30.41 9.57 727 219212 136644 55935484
Liver injury 30.07 9.57 75 219864 41773 56030355
Systemic infection 29.66 9.57 49 219890 3220 56068908
Atrioventricular block first degree 29.66 9.57 75 219864 6690 56065438
Obstructive airways disorder 29.62 9.57 140 219799 17142 56054986
Arteriosclerosis 28.91 9.57 92 219847 9361 56062767
Suicide attempt 28.80 9.57 122 219817 57714 56014414
Heart rate irregular 28.78 9.57 158 219781 20521 56051607
Leukopenia 28.74 9.57 161 219778 70779 56001349
Depression 28.26 9.57 912 219027 179205 55892923
Ventricular extrasystoles 28.11 9.57 100 219839 10770 56061358
Electrolyte imbalance 27.99 9.57 142 219797 17891 56054237
Product substitution issue 27.80 9.57 122 219817 14477 56057651
Coma 27.48 9.57 355 219584 59300 56012828
Supraventricular extrasystoles 27.46 9.57 54 219885 4066 56068062
Gastric disorder 27.00 9.57 222 219717 32988 56039140
Bone marrow failure 26.94 9.57 43 219896 28243 56043885
Cardiac disorder 26.88 9.57 286 219653 45601 56026527
Carotid artery stenosis 26.47 9.57 59 219880 4851 56067277
Essential hypertension 25.99 9.57 57 219882 4636 56067492
Respiratory tract inflammation 25.79 9.57 20 219919 561 56071567
Hepatic steatosis 25.65 9.57 183 219756 26031 56046097
Device expulsion 25.64 9.57 50 219889 30399 56041729
Dysgeusia 25.38 9.57 258 219681 40657 56031471
Congenital bladder anomaly 25.35 9.57 13 219926 171 56071957
Emotional distress 25.30 9.57 201 219738 29562 56042566
Abnormal dreams 25.16 9.57 89 219850 9560 56062568
Sepsis 24.94 9.57 390 219549 139450 55932678
Urachal abnormality 24.83 9.57 13 219926 179 56071949
Device related thrombosis 24.69 9.57 31 219908 1582 56070546
Product prescribing error 24.54 9.57 165 219774 23021 56049107
Somnolence 24.49 9.57 823 219116 162590 55909538
Haemophagocytic lymphohistiocytosis 24.46 9.57 4 219935 9568 56062560
Eosinophilia 24.41 9.57 148 219791 19929 56052199
Non-cardiogenic pulmonary oedema 24.36 9.57 20 219919 610 56071518
Adverse drug reaction 24.17 9.57 152 219787 64980 56007148
Persistent cloaca 24.03 9.57 13 219926 192 56071936
Neutropenic sepsis 23.71 9.57 15 219924 15170 56056958
Pneumonia 23.68 9.57 1325 218614 405773 55666355
Nervousness 23.61 9.57 194 219745 28821 56043307
Nephrocalcinosis 23.18 9.57 24 219915 991 56071137
Sinusitis 23.17 9.57 591 219348 196990 55875138
Diabetes mellitus inadequate control 23.05 9.57 112 219827 13868 56058260
Cardiac murmur 23.04 9.57 97 219842 11304 56060824
Anhedonia 22.95 9.57 88 219851 9826 56062302
Electrocardiogram abnormal 22.87 9.57 77 219862 8067 56064061
Visual acuity reduced 22.84 9.57 149 219790 20577 56051551
Neurosensory hypoacusis 22.79 9.57 13 219926 214 56071914
Withdrawal hypertension 22.71 9.57 11 219928 127 56072001
Sopor 22.70 9.57 29 219910 20893 56051235
Oropharyngeal swelling 22.46 9.57 22 219917 849 56071279
Cholelithiasis 22.20 9.57 244 219695 39220 56032908
Hypocalcaemia 22.18 9.57 190 219749 28570 56043558
Erythrodermic psoriasis 22.03 9.57 23 219916 959 56071169
Gangrene 21.81 9.57 59 219880 5481 56066647
Glycosylated haemoglobin increased 21.79 9.57 94 219845 11071 56061057
Hyperhidrosis 21.75 9.57 501 219438 93587 55978541
Distributive shock 21.74 9.57 24 219915 1067 56071061
Poisoning deliberate 21.68 9.57 6 219933 9947 56062181
Coronary artery occlusion 21.64 9.57 73 219866 7656 56064472
Epilepsy 21.62 9.57 41 219898 25190 56046938
Electrocardiogram ST segment depression 21.42 9.57 38 219901 2645 56069483
Bundle branch block left 21.39 9.57 64 219875 6298 56065830
Myocardial ischaemia 21.39 9.57 99 219840 12017 56060111
Deep vein thrombosis 21.39 9.57 421 219518 76556 55995572
Intestinal malrotation 21.21 9.57 15 219924 364 56071764
Blood creatine phosphokinase increased 21.21 9.57 184 219755 27768 56044360
Foetal death 21.05 9.57 4 219935 8583 56063545
Foetal exposure during pregnancy 21.04 9.57 65 219874 33758 56038370
Knee arthroplasty 21.04 9.57 95 219844 44164 56027964
Urinary incontinence 21.03 9.57 192 219747 29393 56042735
Overdose 21.00 9.57 289 219650 105541 55966587
Drug hypersensitivity 20.86 9.57 871 219068 274334 55797794
Diverticulum 20.71 9.57 92 219847 10974 56061154
Blood pressure decreased 20.68 9.57 335 219604 58715 56013413
Osteoarthritis 20.60 9.57 434 219505 79862 55992266
Acute coronary syndrome 20.44 9.57 84 219855 9684 56062444
Intervertebral disc protrusion 20.39 9.57 150 219789 21544 56050584
Product monitoring error 20.29 9.57 43 219896 3416 56068712
Interstitial lung disease 20.24 9.57 135 219804 56928 56015200
Device related infection 20.15 9.57 34 219905 21846 56050282
Bladder prolapse 20.11 9.57 31 219908 1920 56070208
Pneumocystis jirovecii pneumonia 20.08 9.57 19 219920 15682 56056446
Orthostatic intolerance 20.07 9.57 23 219916 1066 56071062
Polymyalgia rheumatica 20.06 9.57 40 219899 3042 56069086
Hypoparathyroidism 20.03 9.57 18 219921 622 56071506
Hypersensitivity vasculitis 20.01 9.57 47 219892 4001 56068127
Schizophrenia 19.95 9.57 8 219931 10491 56061637
Platelet count decreased 19.88 9.57 294 219645 106089 55966039
Osteonecrosis 19.85 9.57 157 219782 23058 56049070
Mental status changes 19.80 9.57 229 219710 37272 56034856
Bradycardia 19.71 9.57 372 219567 67132 56004996
Premature labour 19.59 9.57 11 219928 11871 56060257
Micturition disorder 19.52 9.57 33 219906 2210 56069918
Hyperglycaemia 19.43 9.57 232 219707 38049 56034079
Cardiac stress test abnormal 19.27 9.57 17 219922 573 56071555
Procalcitonin increased 19.13 9.57 20 219919 835 56071293
Anxiety 19.00 9.57 930 219009 192242 55879886
Tooth erosion 18.89 9.57 15 219924 436 56071692
Gout 18.80 9.57 96 219843 12125 56060003
Mesenteric panniculitis 18.73 9.57 9 219930 102 56072026
Dysuria 18.69 9.57 193 219746 30536 56041592
Cutaneous lupus erythematosus 18.61 9.57 35 219904 2549 56069579
Small cell carcinoma 18.41 9.57 10 219929 149 56071979
Cyanopsia 18.39 9.57 5 219934 7 56072121
Injection site inflammation 18.36 9.57 41 219898 3375 56068753
Therapy partial responder 18.30 9.57 4 219935 7781 56064347
Hypertensive heart disease 18.27 9.57 33 219906 2330 56069798
Neurofibrosarcoma 18.23 9.57 10 219929 152 56071976
Septic shock 18.20 9.57 151 219788 60684 56011444
Fear 18.19 9.57 110 219829 14798 56057330
Bacterial infection 18.14 9.57 123 219816 17207 56054921
Haemodialysis 18.07 9.57 74 219865 8517 56063611
Coronary artery stenosis 18.01 9.57 48 219891 4420 56067708
Bronchopulmonary aspergillosis 17.96 9.57 5 219934 8259 56063869
Pernicious anaemia 17.86 9.57 17 219922 633 56071495
Bronchomalacia 17.81 9.57 11 219928 211 56071917
C-reactive protein increased 17.80 9.57 209 219730 78475 55993653
Peripheral vascular disorder 17.76 9.57 56 219883 5669 56066459
Pancytopenia 17.70 9.57 242 219697 88473 55983655
Liver function test increased 17.55 9.57 54 219885 28079 56044049
Meniscus injury 17.54 9.57 61 219878 6497 56065631
Renal artery stenosis 17.45 9.57 28 219911 1795 56070333
Vertigo 17.43 9.57 305 219634 54267 56017861
Pneumothorax spontaneous 17.41 9.57 18 219921 742 56071386
Diarrhoea 17.37 9.57 2793 217146 635714 55436414
Fibromyalgia 17.35 9.57 149 219790 59454 56012674
Colitis ulcerative 17.30 9.57 44 219895 24347 56047781
Cutaneous T-cell lymphoma 17.30 9.57 24 219915 1351 56070777
Pathological fracture 17.27 9.57 70 219869 8019 56064109
Lacunar infarction 17.19 9.57 38 219901 3107 56069021
Acute myocardial infarction 17.13 9.57 188 219751 30205 56041923
Hypertensive angiopathy 17.10 9.57 8 219931 85 56072043
Hypertrophic cardiomyopathy 17.07 9.57 24 219915 1368 56070760
Sedation 17.05 9.57 74 219865 34780 56037348
Rotator cuff syndrome 17.04 9.57 93 219846 12050 56060078
Body height decreased 16.92 9.57 76 219863 9109 56063019
Oesophageal discomfort 16.90 9.57 10 219929 177 56071951
Rectal prolapse 16.88 9.57 28 219911 1846 56070282
Ventricular fibrillation 16.83 9.57 86 219853 10866 56061262
Intestinal villi atrophy 16.75 9.57 10 219929 180 56071948
Transplant rejection 16.66 9.57 9 219930 9925 56062203
Macular oedema 16.57 9.57 42 219897 3752 56068376
Forced vital capacity decreased 16.47 9.57 20 219919 986 56071142
Polydipsia 16.47 9.57 38 219901 3197 56068931
Depressed level of consciousness 16.46 9.57 141 219798 56292 56015836
Hypophagia 16.45 9.57 179 219760 28697 56043431
Photosensitivity reaction 16.40 9.57 100 219839 13493 56058635
Paraesthesia 16.06 9.57 643 219296 129871 55942257
Fear of injection 16.04 9.57 3 219936 6512 56065616
Neurotoxicity 16.02 9.57 23 219916 15772 56056356
Carotid bruit 15.97 9.57 16 219923 635 56071493
Extrasystoles 15.87 9.57 48 219891 4751 56067377
Meniere's disease 15.78 9.57 10 219929 201 56071927
Tendon rupture 15.76 9.57 65 219874 7505 56064623
Myopathy 15.74 9.57 78 219861 9734 56062394
Plasma cell myeloma 15.73 9.57 112 219827 46534 56025594
Coronary ostial stenosis 15.69 9.57 7 219932 66 56072062
Carpal tunnel syndrome 15.68 9.57 123 219816 18021 56054107
Renal cyst 15.65 9.57 75 219864 9234 56062894
Adenocarcinoma 15.62 9.57 34 219905 2751 56069377
Joint range of motion decreased 15.60 9.57 49 219890 25316 56046812
Glomerulonephritis rapidly progressive 15.57 9.57 18 219921 842 56071286
Blood pressure abnormal 15.54 9.57 99 219840 13561 56058567
Diverticulitis 15.53 9.57 211 219728 35641 56036487
Spinal osteoarthritis 15.35 9.57 105 219834 14731 56057397
Epstein-Barr virus infection 15.34 9.57 5 219934 7458 56064670
Therapeutic product effect incomplete 15.30 9.57 307 219632 105724 55966404
Renal injury 15.23 9.57 72 219867 8815 56063313
Low density lipoprotein increased 15.16 9.57 54 219885 5820 56066308
Heart rate decreased 15.16 9.57 232 219707 40195 56031933
Petechiae 15.15 9.57 95 219844 12944 56059184
Jaw disorder 15.12 9.57 49 219890 5034 56067094
Metabolic alkalosis 15.08 9.57 34 219905 2817 56069311
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.02 9.57 32 219907 2551 56069577
Disability 15.01 9.57 24 219915 15756 56056372
Osmotic demyelination syndrome 15.00 9.57 15 219924 594 56071534
Cardiomegaly 14.99 9.57 113 219826 16354 56055774
Hypoparathyroidism secondary 14.98 9.57 6 219933 42 56072086
Mucosal membrane hyperplasia 14.98 9.57 6 219933 42 56072086
Therapeutic response unexpected 14.98 9.57 116 219823 16928 56055200
Amaurosis fugax 14.97 9.57 13 219926 429 56071699
Insomnia 14.96 9.57 904 219035 190956 55881172
Tooth abscess 14.88 9.57 98 219841 13577 56058551
International normalised ratio decreased 14.86 9.57 43 219896 4153 56067975
Hip fracture 14.82 9.57 166 219773 26807 56045321
Cardiac hypertrophy 14.79 9.57 19 219920 992 56071136
Dystonia 14.78 9.57 16 219923 12405 56059723
Hepatotoxicity 14.73 9.57 67 219872 31086 56041042
Parkinsonism 14.69 9.57 75 219864 9471 56062657
Hypomagnesaemia 14.69 9.57 156 219783 24859 56047269
Confabulation 14.67 9.57 11 219928 293 56071835
Hyponatraemic encephalopathy 14.61 9.57 10 219929 230 56071898
Vision blurred 14.60 9.57 426 219513 82517 55989611
Gait disturbance 14.57 9.57 779 219160 162542 55909586
Mandibular mass 14.56 9.57 9 219930 173 56071955
Prescribed overdose 14.48 9.57 42 219897 22254 56049874
Multiple drug therapy 14.44 9.57 33 219906 2759 56069369
Anaphylactic reaction 14.41 9.57 154 219785 58841 56013287
Blood hyposmosis 14.40 9.57 5 219934 22 56072106
Breast neoplasm 14.38 9.57 22 219917 1354 56070774
Breast cancer stage III 14.38 9.57 5 219934 7158 56064970
Eosinophil count increased 14.34 9.57 75 219864 9562 56062566
Choroidal effusion 14.33 9.57 13 219926 455 56071673
Chest discomfort 14.32 9.57 496 219443 98361 55973767
Skin haemorrhage 14.31 9.57 68 219871 8345 56063783
Thrombocytopenia 14.26 9.57 414 219525 135810 55936318
Dilatation atrial 14.18 9.57 26 219913 1857 56070271
Actinic keratosis 14.01 9.57 29 219910 2266 56069862
Pulpitis dental 13.92 9.57 17 219922 843 56071285
Left ventricular hypertrophy 13.89 9.57 47 219892 4937 56067191
Mouth ulceration 13.86 9.57 64 219875 29576 56042552
Pollakiuria 13.80 9.57 155 219784 25047 56047081
Gastroenteritis clostridial 13.66 9.57 14 219925 571 56071557
Cardiac ventriculogram left 13.65 9.57 3 219936 0 56072128
Renal artery dissection 13.65 9.57 3 219936 0 56072128
Eczema weeping 13.65 9.57 3 219936 0 56072128
Blood uric acid increased 13.63 9.57 42 219897 4200 56067928
Vomiting 13.59 9.57 2180 217759 496048 55576080
Product residue present 13.55 9.57 39 219900 3756 56068372
Accidental exposure to product 13.53 9.57 50 219889 24597 56047531
COVID-19 13.48 9.57 209 219730 74849 55997279
Atrioventricular block 13.46 9.57 58 219881 6829 56065299
Allergic hepatitis 13.42 9.57 5 219934 28 56072100
Coronavirus test positive 13.35 9.57 15 219924 680 56071448
Liver disorder 13.33 9.57 110 219829 44260 56027868
Eosinophilia myalgia syndrome 13.22 9.57 4 219935 10 56072118
White blood cell count decreased 13.16 9.57 383 219556 125607 55946521
Abortion induced 13.14 9.57 11 219928 9634 56062494
Peripheral circulatory failure 13.11 9.57 17 219922 896 56071232
Chest wall mass 13.05 9.57 6 219933 61 56072067
Dysarthria 12.97 9.57 222 219717 39328 56032800
Rhinalgia 12.95 9.57 19 219920 1126 56071002
Cytokine release syndrome 12.95 9.57 14 219925 10861 56061267
Myelodysplastic syndrome 12.91 9.57 28 219911 16378 56055750
Lipohypertrophy 12.91 9.57 14 219925 610 56071518
Blood creatine increased 12.88 9.57 47 219892 5126 56067002
Laryngeal pain 12.84 9.57 41 219898 4179 56067949
Psychotic disorder 12.80 9.57 48 219891 23510 56048618
Skin exfoliation 12.79 9.57 209 219730 36691 56035437
Multiple organ dysfunction syndrome 12.78 9.57 138 219801 52632 56019496
Procedural complication 12.77 9.57 46 219893 4985 56067143
Pain in extremity 12.76 9.57 1338 218601 296093 55776035
Epileptic encephalopathy 12.76 9.57 10 219929 285 56071843
Product commingling 12.75 9.57 8 219931 158 56071970
Ultrasound kidney abnormal 12.73 9.57 5 219934 33 56072095
Endometrial cancer 12.67 9.57 33 219906 2997 56069131
Renal tubular necrosis 12.65 9.57 79 219860 10749 56061379
Encephalitis 12.62 9.57 8 219931 8082 56064046
Post-anoxic myoclonus 12.61 9.57 5 219934 34 56072094
Grip strength decreased 12.58 9.57 28 219911 16228 56055900
Clostridium difficile infection 12.56 9.57 59 219880 27139 56044989
Product administration error 12.51 9.57 131 219808 20798 56051330
Gastritis erosive 12.50 9.57 49 219890 5528 56066600
Renal impairment 12.46 9.57 408 219531 80305 55991823
Osteomyelitis acute 12.43 9.57 9 219930 227 56071901
Basal cell carcinoma 12.43 9.57 152 219787 25069 56047059
Endometrial cancer stage I 12.39 9.57 9 219930 228 56071900
Asthma 12.38 9.57 549 219390 112221 55959907
Glomerulonephritis 12.38 9.57 23 219916 1660 56070468
Microalbuminuria 12.37 9.57 11 219928 375 56071753
Dysphagia 12.34 9.57 413 219526 81534 55990594
Bone erosion 12.25 9.57 25 219914 14949 56057179
Haematotoxicity 12.13 9.57 9 219930 8374 56063754
Arthralgia 12.13 9.57 1747 218192 499922 55572206
Wound treatment 12.07 9.57 8 219931 174 56071954
Complication of device insertion 12.03 9.57 5 219934 6419 56065709
Metastases to fallopian tube 12.02 9.57 5 219934 39 56072089
Atrioventricular block second degree 12.01 9.57 37 219902 3699 56068429
Pituitary apoplexy 11.97 9.57 7 219932 121 56072007
Diabetic neuropathy 11.94 9.57 37 219902 3711 56068417
Tanning 11.90 9.57 6 219933 76 56072052
Vitiligo 11.76 9.57 19 219920 1225 56070903
Prothrombin time abnormal 11.75 9.57 11 219928 401 56071727
Migraine 11.73 9.57 254 219685 86543 55985585
Acute respiratory distress syndrome 11.70 9.57 45 219894 21881 56050247
Foreign body in reproductive tract 11.70 9.57 12 219927 490 56071638
Non-cardiac chest pain 11.69 9.57 50 219889 5866 56066262
Anaemia postoperative 11.69 9.57 26 219913 2135 56069993
Torsade de pointes 11.68 9.57 86 219853 12354 56059774
Ageusia 11.65 9.57 86 219853 12365 56059763
Nodal rhythm 11.63 9.57 22 219917 1609 56070519
Device difficult to use 11.59 9.57 15 219924 10746 56061382
Gastric atony 11.58 9.57 3 219936 3 56072125
Gallbladder disorder 11.57 9.57 111 219828 17223 56054905
Tricuspid valve incompetence 11.54 9.57 90 219849 13163 56058965
Lymphocyte count decreased 11.54 9.57 63 219876 27876 56044252
Pharyngeal oedema 11.44 9.57 90 219849 13195 56058933
Cerebral ischaemia 11.41 9.57 51 219888 6099 56066029
Azotaemia 11.40 9.57 39 219900 4119 56068009
Disseminated intravascular coagulation 11.39 9.57 34 219905 17851 56054277
Pulmonary arterial hypertension 11.37 9.57 59 219880 26444 56045684
Thrombotic microangiopathy 11.33 9.57 12 219927 9399 56062729
Subacute cutaneous lupus erythematosus 11.31 9.57 27 219912 2322 56069806
Angle closure glaucoma 11.29 9.57 25 219914 2046 56070082
Stupor 11.29 9.57 38 219901 3980 56068148
Maternal drugs affecting foetus 11.22 9.57 3 219936 5090 56067038
Macrocytosis 11.19 9.57 27 219912 2339 56069789
Hot flush 11.17 9.57 250 219689 46476 56025652
Blood creatinine abnormal 11.16 9.57 30 219909 2776 56069352
Chills 11.15 9.57 499 219440 102105 55970023
Abdominal panniculectomy 11.12 9.57 3 219936 4 56072124
Cutaneous T-cell lymphoma stage I 11.11 9.57 4 219935 20 56072108
Nocturia 11.06 9.57 56 219883 7050 56065078
Oesophageal oedema 11.04 9.57 5 219934 49 56072079
Lipoedema 10.95 9.57 9 219930 275 56071853
Delayed fontanelle closure 10.95 9.57 4 219935 21 56072107
Muscular weakness 10.92 9.57 506 219433 103946 55968182
Diverticulum oesophageal 10.91 9.57 7 219932 144 56071984
Hyponatraemic syndrome 10.90 9.57 12 219927 532 56071596
Hypertrichosis 10.82 9.57 17 219922 1071 56071057
Thyroid neoplasm 10.77 9.57 36 219903 3757 56068371
Progressive multifocal leukoencephalopathy 10.76 9.57 19 219920 11994 56060134
Respiratory disorder 10.75 9.57 83 219856 33874 56038254
Gastritis 10.74 9.57 193 219746 34509 56037619
Pathogen resistance 10.72 9.57 5 219934 5995 56066133
Hyperammonaemia 10.72 9.57 3 219936 4937 56067191
Adrenocortical carcinoma 10.70 9.57 5 219934 53 56072075
Respiratory syncytial virus infection 10.64 9.57 4 219935 5457 56066671
Allergic cough 10.63 9.57 12 219927 547 56071581
Oral fibroma 10.62 9.57 5 219934 54 56072074
Lip infection 10.61 9.57 6 219933 97 56072031
Shock haemorrhagic 10.61 9.57 66 219873 8967 56063161
Retroperitoneal fibrosis 10.54 9.57 9 219930 290 56071838
Varicose vein ruptured 10.54 9.57 5 219934 55 56072073
Ankylosing spondylitis 10.53 9.57 14 219925 9916 56062212
Renin increased 10.50 9.57 7 219932 154 56071974
Orthostatic hypotension 10.40 9.57 185 219754 33014 56039114
Femoral bruit 10.37 9.57 3 219936 6 56072122
Iliac artery embolism 10.37 9.57 3 219936 6 56072122
Haemorrhagic fever 10.37 9.57 3 219936 6 56072122
Early satiety 10.37 9.57 15 219924 878 56071250
Sleep apnoea syndrome 10.33 9.57 151 219788 25910 56046218
Endometrial hyperplasia 10.31 9.57 14 219925 772 56071356
Serotonin syndrome 10.25 9.57 61 219878 26429 56045699
Adiposis dolorosa 10.19 9.57 9 219930 304 56071824
Juvenile idiopathic arthritis 10.17 9.57 3 219936 4770 56067358
Chondropathy 10.16 9.57 25 219914 2192 56069936
Vertebral artery stenosis 10.15 9.57 5 219934 60 56072068
Antidiuretic hormone abnormality 10.11 9.57 4 219935 27 56072101
Cytopenia 10.09 9.57 14 219925 9741 56062387
Dementia 10.07 9.57 107 219832 17051 56055077
Blood triglycerides increased 10.00 9.57 79 219860 11598 56060530
Respiratory depression 9.97 9.57 21 219918 12414 56059714
Aneurysm 9.93 9.57 27 219912 2516 56069612
Hiatus hernia 9.93 9.57 119 219820 19533 56052595
Pruritus allergic 9.91 9.57 18 219921 1276 56070852
Overweight 9.90 9.57 32 219907 3282 56068846
Back pain 9.89 9.57 1065 218874 236105 55836023
Neuromyopathy 9.89 9.57 12 219927 591 56071537
Poor personal hygiene 9.87 9.57 9 219930 317 56071811
Unintended pregnancy 9.79 9.57 4 219935 5187 56066941
Non-Hodgkin's lymphoma 9.77 9.57 19 219920 1419 56070709
Coma acidotic 9.76 9.57 6 219933 114 56072014
Spondylolysis 9.74 9.57 5 219934 66 56072062
Immune reconstitution inflammatory syndrome 9.72 9.57 5 219934 5669 56066459
Gastrointestinal toxicity 9.72 9.57 6 219933 6150 56065978
Occult blood positive 9.69 9.57 32 219907 3319 56068809
Renal artery stent placement 9.63 9.57 6 219933 117 56072011
Neuroglycopenia 9.62 9.57 10 219929 415 56071713
Hypovitaminosis 9.60 9.57 13 219926 715 56071413

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 456.20 10.35 925 120443 72874 31503102
Angioedema 327.00 10.35 514 120854 33104 31542872
Off label use 289.64 10.35 558 120810 346716 31229260
Hypokalaemia 238 10.35 589 120779 52985 31522991
Acute kidney injury 228.12 10.35 1838 119530 277876 31298100
Drug abuse 207.04 10.35 42 121326 87716 31488260
Syncope 155.24 10.35 692 120676 84490 31491486
Cerebrovascular accident 152.67 10.35 656 120712 78828 31497148
Dizziness 152.44 10.35 1291 120077 197856 31378120
Death 131.58 10.35 826 120542 359743 31216233
Hypertension 126.08 10.35 881 120487 127219 31448757
Pyrexia 117.05 10.35 684 120684 303156 31272820
Coronary artery disease 114.03 10.35 412 120956 45675 31530301
Product use in unapproved indication 107.45 10.35 133 121235 99038 31476938
Blood pressure increased 102.07 10.35 586 120782 79047 31496929
Neutropenia 97.22 10.35 249 121119 140115 31435861
Febrile neutropenia 95.75 10.35 202 121166 121647 31454329
Blood pressure inadequately controlled 93.97 10.35 77 121291 2392 31573584
Hypotension 93.66 10.35 1195 120173 203423 31372553
Milk-alkali syndrome 93.56 10.35 44 121324 484 31575492
Pneumonia 93.12 10.35 829 120539 334483 31241493
Pancreatitis acute 85.02 10.35 253 121115 25347 31550629
Myocardial infarction 83.16 10.35 729 120639 112725 31463251
Blood glucose increased 81.88 10.35 455 120913 60628 31515348
Sepsis 73.79 10.35 315 121053 151614 31424362
Toxicity to various agents 73.79 10.35 401 120967 181086 31394890
Blood potassium decreased 71.17 10.35 179 121189 16247 31559729
Dehydration 68.36 10.35 727 120641 118384 31457592
Drug ineffective 64.48 10.35 1097 120271 394476 31181500
Thrombocytopenia 63.31 10.35 306 121062 142441 31433535
Cytomegalovirus infection 57.85 10.35 12 121356 24695 31551281
Pancreatitis 55.84 10.35 278 121090 35493 31540483
Treatment failure 51.61 10.35 48 121320 40744 31535232
Hypertensive crisis 50.37 10.35 103 121265 8144 31567832
Hypovolaemia 49.30 10.35 103 121265 8269 31567707
Bundle branch block left 48.99 10.35 81 121287 5437 31570539
Product use issue 48.05 10.35 90 121278 56669 31519307
Foetal exposure during pregnancy 47.26 10.35 52 121316 40824 31535152
Hepatic function abnormal 47.05 10.35 53 121315 41169 31534807
Interstitial lung disease 43.95 10.35 107 121261 61296 31514680
Lactic acidosis 42.83 10.35 238 121130 31699 31544277
Blood mercury abnormal 40.88 10.35 19 121349 203 31575773
Blood creatinine increased 40.50 10.35 520 120848 88558 31487418
Intentional product use issue 39.39 10.35 81 121287 49266 31526710
Cardiomegaly 39.14 10.35 133 121235 14292 31561684
5-hydroxyindolacetic acid in urine increased 39.10 10.35 19 121349 226 31575750
Leukopenia 38.89 10.35 104 121264 57724 31518252
Injury 38.79 10.35 164 121204 19545 31556431
Hypochloraemia 38.27 10.35 25 121343 542 31575434
Cardiac failure congestive 38.04 10.35 468 120900 78919 31497057
Hospitalisation 37.88 10.35 84 121284 49723 31526253
Metabolic alkalosis 37.63 10.35 35 121333 1292 31574684
Sprue-like enteropathy 37.05 10.35 23 121345 455 31575521
Orthostatic intolerance 36.44 10.35 27 121341 721 31575255
Carotid artery stenosis 35.68 10.35 64 121304 4588 31571388
Myelosuppression 35.44 10.35 7 121361 14913 31561063
Cytokine release syndrome 35.21 10.35 10 121358 16632 31559344
Interstitial granulomatous dermatitis 35.01 10.35 16 121352 164 31575812
Blood urea increased 34.22 10.35 209 121159 28803 31547173
Plasma cell myeloma 34.12 10.35 107 121261 56424 31519552
Renal artery stenosis 33.19 10.35 41 121327 2101 31573875
Blood pressure systolic increased 33.03 10.35 155 121213 19315 31556661
Drug resistance 32.85 10.35 25 121343 23428 31552548
Arteriosclerosis coronary artery 32.78 10.35 106 121262 11102 31564874
Hypomagnesaemia 32.54 10.35 152 121216 18906 31557070
Pancytopenia 31.64 10.35 200 121168 87116 31488860
Blood chloride decreased 31.46 10.35 53 121315 3613 31572363
Bronchopulmonary aspergillosis 31.15 10.35 7 121361 13627 31562349
Vertigo 30.92 10.35 172 121196 22913 31553063
Drug intolerance 30.34 10.35 100 121268 51933 31524043
Bone marrow failure 29.84 10.35 38 121330 27970 31548006
Renal failure 29.40 10.35 648 120720 122682 31453294
Glycosylated haemoglobin increased 29.20 10.35 97 121271 10303 31565673
Blood cholesterol increased 29.03 10.35 135 121233 16758 31559218
Infection 29.00 10.35 189 121179 81742 31494234
Pulmonary valve disease 28.84 10.35 17 121351 305 31575671
Inappropriate antidiuretic hormone secretion 28.31 10.35 102 121266 11285 31564691
Granulomatous pneumonitis 28.27 10.35 9 121359 29 31575947
Acute myocardial infarction 28.07 10.35 308 121060 50515 31525461
Pericardial disease 27.64 10.35 18 121350 388 31575588
Oedema peripheral 27.42 10.35 581 120787 109258 31466718
Angina pectoris 27.41 10.35 201 121167 29440 31546536
Pneumonia aspiration 26.52 10.35 69 121299 38657 31537319
Actinic keratosis 26.48 10.35 53 121315 4126 31571850
Neutrophil count decreased 26.48 10.35 90 121278 46304 31529672
Intentional self-injury 26.38 10.35 9 121359 13306 31562670
Low density lipoprotein decreased 26.35 10.35 26 121342 1034 31574942
Transient ischaemic attack 26.31 10.35 170 121198 23886 31552090
Mitral valve incompetence 26.25 10.35 115 121253 13918 31562058
Sopor 26.25 10.35 6 121362 11546 31564430
Erectile dysfunction 26.22 10.35 144 121224 19091 31556885
Hypertensive emergency 26.21 10.35 25 121343 953 31575023
Aspergillus infection 26.17 10.35 6 121362 11522 31564454
Nodular rash 25.31 10.35 11 121357 99 31575877
Swollen tongue 25.29 10.35 107 121261 12755 31563221
Liver disorder 25.23 10.35 47 121321 29660 31546316
Fall 24.81 10.35 908 120460 185181 31390795
Platelet count decreased 24.32 10.35 288 121080 110147 31465829
Lichen planus 24.04 10.35 23 121345 880 31575096
Drug-induced liver injury 23.99 10.35 35 121333 24328 31551648
Blood sodium decreased 23.87 10.35 119 121249 15196 31560780
Blood triglycerides increased 23.72 10.35 108 121260 13289 31562687
Lower respiratory tract infection 23.69 10.35 45 121323 28192 31547784
Tricuspid valve incompetence 23.59 10.35 81 121287 8748 31567228
Hypercalcaemia 23.41 10.35 111 121257 13889 31562087
Bacteraemia 23.20 10.35 20 121348 17614 31558362
Neurotoxicity 23.11 10.35 17 121351 16209 31559767
Disseminated intravascular coagulation 22.78 10.35 27 121341 20510 31555466
Angina unstable 22.69 10.35 94 121274 11101 31564875
Pseudolymphoma 22.64 10.35 18 121350 535 31575441
Graft versus host disease 22.62 10.35 6 121362 10441 31565535
Polydipsia 22.56 10.35 45 121323 3495 31572481
Hyperlipidaemia 22.49 10.35 105 121263 13055 31562921
High density lipoprotein decreased 22.47 10.35 42 121326 3108 31572868
Malaise 22.47 10.35 483 120885 168028 31407948
Electrolyte imbalance 22.31 10.35 99 121269 12049 31563927
Renal injury 21.97 10.35 90 121278 10575 31565401
Peritonitis 21.90 10.35 16 121352 15311 31560665
Osteoarthritis 21.63 10.35 136 121232 18931 31557045
Vestibular neuronitis 21.40 10.35 12 121356 195 31575781
IgM nephropathy 21.31 10.35 8 121360 47 31575929
Seizure 21.27 10.35 262 121106 99506 31476470
Blood pressure decreased 21.11 10.35 279 121089 47812 31528164
Hepatic neoplasm 21.03 10.35 31 121337 1884 31574092
Respiratory depression 20.92 10.35 15 121353 14495 31561481
Arrhythmia 20.88 10.35 206 121162 32871 31543105
Congenital diaphragmatic anomaly 20.82 10.35 7 121361 28 31575948
Ventricular hypertrophy 20.79 10.35 49 121319 4267 31571709
Drug dependence 20.74 10.35 34 121334 22545 31553431
Choroidal detachment 20.69 10.35 15 121353 387 31575589
Aplastic anaemia 20.48 10.35 5 121363 9198 31566778
Choroidal effusion 20.28 10.35 11 121357 167 31575809
Lymphocyte count decreased 20.00 10.35 30 121338 20619 31555357
Dysgeusia 19.94 10.35 156 121212 23310 31552666
Pulmonary valve stenosis congenital 19.87 10.35 10 121358 129 31575847
Extrasystoles 19.85 10.35 43 121325 3539 31572437
Physical examination abnormal 19.73 10.35 13 121355 286 31575690
Intestinal villi atrophy 19.73 10.35 10 121358 131 31575845
Gout 19.61 10.35 128 121240 18046 31557930
Shock 19.49 10.35 151 121217 22494 31553482
Acquired acrodermatitis enteropathica 19.40 10.35 5 121363 5 31575971
Microalbuminuria 19.25 10.35 18 121350 669 31575307
Pneumocystis jirovecii pneumonia 19.19 10.35 25 121343 18226 31557750
Immune reconstitution inflammatory syndrome 19.09 10.35 4 121364 8174 31567802
Lymphomatoid papulosis 19.08 10.35 11 121357 189 31575787
Myalgia 19.05 10.35 408 120960 76850 31499126
Alkalosis hypochloraemic 18.97 10.35 13 121355 306 31575670
Pharyngeal oedema 18.97 10.35 57 121311 5739 31570237
Neutropenic sepsis 18.92 10.35 12 121356 12367 31563609
Contraindicated product administered 18.89 10.35 29 121339 19743 31556233
Polyuria 18.74 10.35 69 121299 7714 31568262
Schizophrenia 18.72 10.35 9 121359 10821 31565155
Product complaint 18.72 10.35 55 121313 5469 31570507
Drug reaction with eosinophilia and systemic symptoms 18.69 10.35 56 121312 29962 31546014
Hemiparesis 18.65 10.35 109 121259 14785 31561191
Septic shock 18.49 10.35 163 121205 65995 31509981
Chest pain 18.42 10.35 582 120786 116375 31459601
C-reactive protein increased 18.36 10.35 110 121258 48540 31527436
Toxic epidermal necrolysis 18.30 10.35 29 121339 19495 31556481
Renin decreased 18.28 10.35 4 121364 0 31575976
CD4/CD8 ratio increased 18.28 10.35 4 121364 0 31575976
Mucosal inflammation 18.17 10.35 69 121299 34358 31541618
Vascular purpura 18.12 10.35 25 121343 1429 31574547
Akathisia 18.10 10.35 3 121365 7250 31568726
Diastolic dysfunction 17.96 10.35 53 121315 5282 31570694
Gastrointestinal tract mucosal pigmentation 17.96 10.35 14 121354 404 31575572
Arteriosclerosis 17.74 10.35 85 121283 10682 31565294
Mitral valve disease 17.70 10.35 23 121345 1240 31574736
Bradycardia 17.70 10.35 368 121000 68959 31507017
Left ventricular hypertrophy 17.65 10.35 65 121303 7267 31568709
Mastitis 17.65 10.35 10 121358 166 31575810
Muscle necrosis 17.54 10.35 19 121349 844 31575132
Precancerous skin lesion 17.51 10.35 16 121352 577 31575399
Therapeutic product effect incomplete 17.45 10.35 97 121271 43599 31532377
Renal artery angioplasty 17.39 10.35 5 121363 10 31575966
Renal artery stent placement 17.39 10.35 5 121363 10 31575966
Spinal cord infarction 17.34 10.35 12 121356 287 31575689
Expired product administered 17.26 10.35 37 121331 3024 31572952
Low density lipoprotein increased 17.13 10.35 44 121324 4044 31571932
Carcinoid tumour of the gastrointestinal tract 17.04 10.35 7 121361 54 31575922
Sedation 17.01 10.35 29 121339 18936 31557040
Malignant neoplasm progression 17.00 10.35 207 121161 78791 31497185
Haemophagocytic lymphohistiocytosis 16.93 10.35 12 121356 11666 31564310
Dystonia 16.92 10.35 9 121359 10216 31565760
Supraventricular extrasystoles 16.91 10.35 37 121331 3067 31572909
Aortic arteriosclerosis 16.89 10.35 44 121324 4079 31571897
Neoplasm 16.84 10.35 47 121321 4539 31571437
Sinus bradycardia 16.82 10.35 91 121277 11996 31563980
Hypophagia 16.82 10.35 143 121225 21899 31554077
Aortic valve incompetence 16.74 10.35 53 121315 5488 31570488
Stomatitis 16.61 10.35 86 121282 39352 31536624
Atrial fibrillation 16.58 10.35 561 120807 113222 31462754
Colitis 16.57 10.35 70 121298 33817 31542159
Coronary artery occlusion 16.52 10.35 81 121287 10275 31565701
Laryngeal cleft 16.49 10.35 5 121363 13 31575963
Pancreatitis necrotising 16.46 10.35 32 121336 2439 31573537
Coronary arterial stent insertion 16.38 10.35 43 121325 4005 31571971
Acute myeloid leukaemia 16.33 10.35 29 121339 18643 31557333
Occult blood 16.16 10.35 16 121352 639 31575337
Kidney transplant rejection 16.12 10.35 4 121364 7278 31568698
Fatigue 16.12 10.35 1491 119877 333715 31242261
Lymphangiectasia intestinal 16.05 10.35 4 121364 3 31575973
Supraventricular tachycardia 16.00 10.35 80 121288 10227 31565749
Myocardial ischaemia 15.97 10.35 114 121254 16553 31559423
Type 2 diabetes mellitus 15.88 10.35 104 121264 14680 31561296
Dilatation atrial 15.85 10.35 27 121341 1857 31574119
Eosinophilic colitis 15.58 10.35 10 121358 210 31575766
Epilepsy 15.57 10.35 36 121332 21005 31554971
Paresis cranial nerve 15.55 10.35 7 121361 69 31575907
Hypoaesthesia 15.51 10.35 301 121067 55721 31520255
Anhedonia 15.48 10.35 63 121305 7379 31568597
Product monitoring error 15.47 10.35 37 121331 3253 31572723
Hormone level abnormal 15.44 10.35 12 121356 345 31575631
Transplant rejection 15.41 10.35 9 121359 9699 31566277
Gastrointestinal angiodysplasia 15.32 10.35 15 121353 591 31575385
Inappropriate schedule of product administration 15.19 10.35 123 121245 50700 31525276
Fear 15.19 10.35 77 121291 9897 31566079
Balance disorder 15.15 10.35 214 121154 37208 31538768
Rhabdomyolysis 15.11 10.35 334 121034 63247 31512729
Exposure during pregnancy 15.09 10.35 7 121361 8591 31567385
Shoshin beriberi 15.05 10.35 7 121361 75 31575901
Coma 15.03 10.35 94 121274 41056 31534920
Miosis 15.00 10.35 7 121361 8563 31567413
Premature baby 14.97 10.35 29 121339 18037 31557939
Asthenia 14.91 10.35 1025 120343 223730 31352246
Synovitis 14.89 10.35 15 121353 12268 31563708
Waist circumference increased 14.84 10.35 17 121351 804 31575172
Ascites 14.81 10.35 94 121274 40919 31535057
Hypercalciuria 14.77 10.35 11 121357 296 31575680
Aggression 14.77 10.35 83 121285 37208 31538768
Renal tubular necrosis 14.75 10.35 102 121266 14657 31561319
Transaminases increased 14.73 10.35 46 121322 24295 31551681
Echocardiogram abnormal 14.73 10.35 18 121350 912 31575064
Acute cutaneous lupus erythematosus 14.73 10.35 7 121361 79 31575897
Intestinal intraepithelial lymphocytes increased 14.63 10.35 4 121364 6 31575970
Hemiataxia 14.63 10.35 6 121362 46 31575930
Brain stem infarction 14.59 10.35 20 121348 1136 31574840
Multiple organ dysfunction syndrome 14.57 10.35 179 121189 68024 31507952
Basal cell carcinoma 14.43 10.35 119 121249 18060 31557916
Febrile bone marrow aplasia 14.38 10.35 6 121362 7840 31568136
Drug ineffective for unapproved indication 14.36 10.35 29 121339 17761 31558215
Hyperkalaemia 14.34 10.35 335 121033 64016 31511960
Electrocardiogram U-wave abnormality 14.31 10.35 6 121362 49 31575927
Tumour lysis syndrome 14.28 10.35 23 121345 15362 31560614
Enterocolitis 14.27 10.35 5 121363 7269 31568707
Torsade de pointes 14.26 10.35 58 121310 6792 31569184
White blood cell count decreased 14.24 10.35 242 121126 87156 31488820
Therapy non-responder 14.08 10.35 74 121294 33737 31542239
Patent ductus arteriosus 14.04 10.35 35 121333 3158 31572818
Atrioventricular block first degree 13.93 10.35 51 121317 5686 31570290
Pathogen resistance 13.91 10.35 8 121360 8693 31567283
Substance abuse 13.90 10.35 5 121363 7153 31568823
Cytopenia 13.87 10.35 13 121355 10997 31564979
Renin increased 13.79 10.35 7 121361 92 31575884
Diffuse large B-cell lymphoma 13.73 10.35 8 121360 8633 31567343
Atrioventricular block 13.72 10.35 60 121308 7255 31568721
Weight loss poor 13.70 10.35 8 121360 141 31575835
Orthostatic hypotension 13.69 10.35 147 121221 23972 31552004
Agitation 13.62 10.35 137 121231 54032 31521944
Shock hypoglycaemic 13.59 10.35 7 121361 95 31575881
Infective pulmonary exacerbation of cystic fibrosis 13.53 10.35 4 121364 6480 31569496
Osteitis deformans 13.52 10.35 5 121363 28 31575948
Bundle branch block right 13.47 10.35 58 121310 6966 31569010
Tendon rupture 13.42 10.35 55 121313 6464 31569512
Preternatural anus 13.40 10.35 7 121361 98 31575878
Photosensitivity reaction 13.40 10.35 74 121294 9830 31566146
Rales 13.37 10.35 67 121301 8572 31567404
Intestinal angioedema 13.35 10.35 9 121359 206 31575770
Carcinogenicity 13.34 10.35 6 121362 59 31575917
Pyelitis 13.28 10.35 7 121361 100 31575876
Vision blurred 13.27 10.35 230 121138 41685 31534291
Infusion related reaction 13.16 10.35 119 121249 47936 31528040
Aortic valve stenosis 13.14 10.35 29 121339 2417 31573559
Gait disturbance 13.09 10.35 389 120979 77106 31498870
Hypertensive heart disease 13.04 10.35 27 121341 2154 31573822
Cutaneous T-cell lymphoma 12.91 10.35 21 121347 1390 31574586
Renal artery restenosis 12.78 10.35 4 121364 12 31575964
Liver function test increased 12.78 10.35 18 121350 12696 31563280
Fluid intake reduced 12.76 10.35 34 121334 3195 31572781
Alanine aminotransferase increased 12.73 10.35 205 121163 74451 31501525
Dermatosis 12.70 10.35 10 121358 293 31575683
Cardiac discomfort 12.67 10.35 13 121355 542 31575434
Electrocardiogram T wave amplitude decreased 12.63 10.35 9 121359 226 31575750
Parotitis 12.59 10.35 17 121351 952 31575024
Meningitis streptococcal 12.58 10.35 5 121363 35 31575941
Forced expiratory flow decreased 12.55 10.35 8 121360 166 31575810
Blood uric acid increased 12.53 10.35 53 121315 6317 31569659
Macular ischaemia 12.52 10.35 6 121362 69 31575907
Troponin I increased 12.51 10.35 26 121342 2079 31573897
Stenosis 12.51 10.35 19 121349 1186 31574790
Angiopathy 12.46 10.35 38 121330 3857 31572119
Weaning failure 12.42 10.35 9 121359 232 31575744
Neuroleptic malignant syndrome 12.37 10.35 29 121339 16840 31559136
Peripheral vascular disorder 12.37 10.35 43 121325 4673 31571303
Electrocardiogram QT interval 12.35 10.35 5 121363 37 31575939
High frequency ablation 12.34 10.35 8 121360 171 31575805
Gastrointestinal mucosal necrosis 12.34 10.35 8 121360 171 31575805
Renovascular hypertension 12.31 10.35 4 121364 14 31575962
Electrocardiogram Q wave abnormal 12.29 10.35 11 121357 386 31575590
Intentional product misuse 12.21 10.35 90 121278 37861 31538115
Accelerated hypertension 12.03 10.35 9 121359 244 31575732
Cataract nuclear 12.02 10.35 12 121356 484 31575492
Pemphigoid 12.00 10.35 63 121305 8208 31567768
Rheumatoid arthritis 11.98 10.35 121 121247 47688 31528288
Coronary artery bypass 11.94 10.35 43 121325 4756 31571220
Urine albumin/creatinine ratio increased 11.91 10.35 8 121360 182 31575794
Squamous cell carcinoma 11.90 10.35 76 121292 10635 31565341
Suture insertion 11.80 10.35 5 121363 42 31575934
Abnormal behaviour 11.78 10.35 49 121319 23779 31552197
Pleural effusion 11.71 10.35 209 121159 74711 31501265
Cardiac disorder 11.64 10.35 213 121155 39001 31536975
Aortic valve sclerosis 11.60 10.35 15 121353 805 31575171
Ventricular arrhythmia 11.47 10.35 43 121325 4848 31571128
Hyperammonaemia 11.46 10.35 4 121364 5829 31570147
Myopathy 11.45 10.35 76 121292 10776 31565200
Left ventricular dysfunction 11.41 10.35 68 121300 9289 31566687
Enterococcal infection 11.36 10.35 10 121358 8721 31567255
Mechanical urticaria 11.36 10.35 6 121362 86 31575890
Indifference 11.34 10.35 7 121361 137 31575839
Myosclerosis 11.31 10.35 9 121359 268 31575708
Dissociation 11.30 10.35 19 121349 1293 31574683
Uveitis 11.28 10.35 6 121362 6810 31569166
Chromatopsia 11.22 10.35 8 121360 201 31575775
Trigger finger 11.22 10.35 14 121354 725 31575251
Left ventricle outflow tract obstruction 11.12 10.35 7 121361 142 31575834
Nephropathy 11.10 10.35 46 121322 5433 31570543
Post procedural haematoma 11.10 10.35 20 121348 1439 31574537
Electrocardiogram ST segment abnormal 11.08 10.35 12 121356 533 31575443
Swelling face 11.06 10.35 128 121240 21262 31554714
Prothrombin time prolonged 10.97 10.35 66 121302 9046 31566930
Nail discolouration 10.92 10.35 15 121353 854 31575122
Emotional distress 10.88 10.35 93 121275 14263 31561713
Renal function test abnormal 10.83 10.35 26 121342 2291 31573685
Clumsiness 10.82 10.35 21 121347 1598 31574378
Electrocardiogram QT prolonged 10.82 10.35 205 121163 37782 31538194
Renal artery arteriosclerosis 10.73 10.35 4 121364 23 31575953
Condition aggravated 10.69 10.35 516 120852 163493 31412483
Abdominal tenderness 10.67 10.35 35 121333 3693 31572283
Carotid artery occlusion 10.63 10.35 24 121344 2032 31573944
Rotator cuff syndrome 10.60 10.35 44 121324 5201 31570775
Fibrous histiocytoma 10.59 10.35 7 121361 155 31575821
Anhidrosis 10.57 10.35 6 121362 100 31575876
Myelodysplastic syndrome 10.54 10.35 38 121330 19213 31556763
Dilatation ventricular 10.51 10.35 27 121341 2482 31573494
Mydriasis 10.51 10.35 6 121362 6546 31569430
Diverticulum 10.50 10.35 51 121317 6443 31569533
Staring 10.38 10.35 19 121349 1383 31574593
Glomerular filtration rate abnormal 10.35 10.35 14 121354 785 31575191

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 1473.41 9.58 2370 266206 157717 70502151
Hypokalaemia 658.54 9.58 1502 267074 129686 70530182
Off label use 480.72 9.58 1344 267232 741716 69918152
Acute kidney injury 477.14 9.58 3251 265325 471373 70188495
Angioedema 447.80 9.58 860 267716 65750 70594118
Drug abuse 334.58 9.58 74 268502 147182 70512686
Cerebrovascular accident 323.38 9.58 1235 267341 142235 70517633
Blood pressure increased 268.63 9.58 1416 267160 187101 70472767
Hypertension 259.70 9.58 1964 266612 294069 70365799
Maternal exposure during pregnancy 253.99 9.58 62 268514 115283 70544585
Coronary artery disease 250.26 9.58 658 267918 62078 70597790
Hand deformity 243.56 9.58 23 268553 86459 70573409
Pemphigus 242.27 9.58 19 268557 83017 70576851
Syncope 241.78 9.58 1253 267323 164456 70495412
Myocardial infarction 241.59 9.58 1285 267291 170360 70489508
Blood potassium decreased 236.60 9.58 507 268069 41914 70617954
Pericarditis 215.14 9.58 32 268544 84673 70575195
Dizziness 213.27 9.58 2688 265888 461453 70198415
Synovitis 199.52 9.58 121 268455 129107 70530761
Systemic lupus erythematosus 189.84 9.58 74 268502 101828 70558040
Drug ineffective 173.01 9.58 2514 266062 937238 69722630
Dehydration 172.79 9.58 1454 267122 224688 70435180
Drug intolerance 161.41 9.58 387 268189 225300 70434568
Duodenal ulcer perforation 160.12 9.58 8 268568 51104 70608764
Lower respiratory tract infection 157.66 9.58 116 268460 111797 70548071
Treatment failure 156.61 9.58 189 268387 143953 70515915
Hypotension 153.21 9.58 2263 266313 402118 70257750
Contraindicated product administered 152.17 9.58 171 268405 134441 70525427
Glossodynia 149.61 9.58 70 268506 86417 70573451
Product use in unapproved indication 147.39 9.58 357 268219 207121 70452747
Blood pressure inadequately controlled 140.00 9.58 137 268439 5455 70654413
Febrile neutropenia 136.29 9.58 363 268213 203955 70455913
Lactic acidosis 136.02 9.58 547 268029 64477 70595391
Neutropenia 134.31 9.58 510 268066 256646 70403222
Exposure during pregnancy 132.78 9.58 84 268492 87633 70572235
Death 132.77 9.58 1263 267313 508798 70151070
Inappropriate antidiuretic hormone secretion 131.86 9.58 280 268296 22996 70636872
Pyrexia 129.44 9.58 1574 267002 605378 70054490
Rheumatoid arthritis 128.87 9.58 617 267959 291188 70368680
Pancreatitis acute 122.82 9.58 414 268162 44810 70615058
Blood glucose increased 120.42 9.58 734 267842 102248 70557620
Milk-alkali syndrome 119.86 9.58 68 268508 1145 70658723
Toxicity to various agents 118.81 9.58 903 267673 381269 70278599
Fall 117.90 9.58 2347 266229 441749 70218119
Infection 112.01 9.58 415 268161 210370 70449498
Hypovolaemia 110.49 9.58 209 268367 15784 70644084
Pneumonia 108.60 9.58 1597 266979 594635 70065233
Rheumatoid factor positive 108.52 9.58 25 268551 48375 70611493
Alopecia 107.96 9.58 387 268189 198103 70461765
Hypertensive crisis 105.99 9.58 229 268347 19033 70640835
Infusion related reaction 104.89 9.58 389 268187 197145 70462723
Hypochloraemia 104.13 9.58 77 268499 2074 70657794
Sprue-like enteropathy 101.07 9.58 59 268517 1051 70658817
Cardiac failure congestive 99.69 9.58 864 267712 134593 70525275
Sleep disorder due to general medical condition, insomnia type 96.73 9.58 11 268565 35721 70624147
Muscle injury 96.68 9.58 15 268561 38479 70621389
Therapeutic product effect decreased 94.64 9.58 255 268321 142763 70517105
Cytomegalovirus infection 94.35 9.58 18 268558 39740 70620128
Sepsis 93.97 9.58 542 268034 244003 70415865
Asthenia 92.20 9.58 2326 266250 455340 70204528
Folliculitis 91.52 9.58 24 268552 42546 70617322
Product use issue 90.60 9.58 362 268214 179575 70480293
Gastrooesophageal reflux disease 88.81 9.58 619 267957 90220 70569648
Hypertensive emergency 88.61 9.58 74 268502 2389 70657479
Condition aggravated 88.34 9.58 1116 267460 426519 70233349
Intentional product use issue 88.24 9.58 203 268373 119939 70539929
Arthropathy 86.02 9.58 286 268290 149771 70510097
Hepatic function abnormal 85.20 9.58 79 268497 67917 70591951
Transient ischaemic attack 83.25 9.58 370 268206 45574 70614294
Renal failure 81.45 9.58 1083 267493 187987 70471881
Irritable bowel syndrome 79.31 9.58 47 268529 50803 70609065
Chest pain 76.93 9.58 1358 267218 249902 70409966
Intentional self-injury 75.81 9.58 14 268562 31636 70628232
Angina pectoris 75.46 9.58 373 268203 48010 70611858
Joint swelling 75.00 9.58 606 267970 252605 70407263
Myelosuppression 70.79 9.58 14 268562 30131 70629737
Neutrophil count decreased 69.06 9.58 132 268444 83424 70576444
Blood sodium decreased 69.04 9.58 266 268310 30732 70629136
Bundle branch block left 68.28 9.58 133 268443 10266 70649602
Helicobacter infection 68.16 9.58 66 268510 55590 70604278
Blood urea increased 68.13 9.58 349 268227 45560 70614308
Wound 67.62 9.58 173 268403 98559 70561309
Blood creatinine increased 67.43 9.58 833 267743 142168 70517700
Angina unstable 66.74 9.58 170 268406 15723 70644145
Thrombocytopenia 66.41 9.58 582 267994 238528 70421340
Discomfort 66.03 9.58 193 268383 105243 70554625
Pancreatitis 65.99 9.58 435 268141 62233 70597635
Oedema peripheral 63.24 9.58 1214 267362 226877 70432991
Stomatitis 63.12 9.58 261 268315 128250 70531618
Blood pressure systolic increased 63.08 9.58 402 268174 56857 70603011
Hyperlipidaemia 60.90 9.58 214 268362 23649 70636219
Blister 60.81 9.58 187 268389 100339 70559529
Abortion spontaneous 60.72 9.58 13 268563 26466 70633402
Drug resistance 59.98 9.58 35 268541 38155 70621713
Drug interaction 59.77 9.58 1878 266698 379563 70280305
Lung diffusion test abnormal 59.72 9.58 26 268550 238 70659630
Sinus bradycardia 58.70 9.58 210 268366 23413 70636455
Product complaint 56.83 9.58 136 268440 12095 70647773
Hyperkalaemia 56.02 9.58 634 267942 105957 70553911
Interstitial lung disease 54.98 9.58 207 268369 104478 70555390
Red blood cell sedimentation rate abnormal 54.69 9.58 5 268571 19298 70640570
Pregnancy 53.88 9.58 12 268564 23769 70636099
Carotid artery stenosis 53.67 9.58 105 268471 8131 70651737
Orthostatic intolerance 53.28 9.58 48 268528 1719 70658149
Blood chloride decreased 52.27 9.58 101 268475 7749 70652119
Hypercalcaemia 51.44 9.58 262 268314 34123 70625745
Leukopenia 51.34 9.58 218 268358 106342 70553526
Swollen tongue 51.10 9.58 276 268300 36770 70623098
Plasma cell myeloma 51.10 9.58 127 268449 73074 70586794
Bronchopulmonary aspergillosis 50.93 9.58 9 268567 20993 70638875
Hypoglycaemia 50.82 9.58 564 268012 93800 70566068
Hepatic enzyme increased 50.55 9.58 367 268209 156623 70503245
Mitral valve incompetence 49.74 9.58 217 268359 26511 70633357
Therapy non-responder 49.47 9.58 139 268437 76776 70583092
Bone marrow failure 49.34 9.58 68 268508 48942 70610926
Ventricular hypertrophy 49.19 9.58 89 268487 6495 70653373
Pancytopenia 47.81 9.58 355 268221 150752 70509116
Electrolyte imbalance 47.66 9.58 215 268361 26646 70633222
Atrial fibrillation 46.67 9.58 968 267608 183380 70476488
Hypomagnesaemia 46.64 9.58 289 268287 40475 70619393
Malignant neoplasm progression 46.61 9.58 270 268306 121469 70538399
Swelling 46.31 9.58 473 268103 188066 70471802
Abdominal discomfort 46.19 9.58 555 268021 214103 70445765
Rhabdomyolysis 46.07 9.58 560 268016 95200 70564668
Acute myocardial infarction 46.04 9.58 450 268126 72437 70587431
Sopor 45.87 9.58 31 268545 31236 70628632
Renal artery stenosis 45.30 9.58 59 268517 3225 70656643
Pemphigoid 45.03 9.58 136 268440 13886 70645982
Blood pressure diastolic decreased 44.74 9.58 205 268371 25575 70634293
Intestinal angioedema 44.65 9.58 32 268544 820 70659048
Platelet count decreased 44.23 9.58 446 268130 177776 70482092
Cardiomegaly 43.96 9.58 197 268379 24348 70635520
Arterial occlusive disease 43.69 9.58 93 268483 7649 70652219
C-reactive protein abnormal 43.58 9.58 49 268527 38530 70621338
Glycosylated haemoglobin increased 43.55 9.58 155 268421 17236 70642632
Loss of employment 43.35 9.58 48 268528 2211 70657657
Arrhythmia 42.79 9.58 361 268215 55782 70604086
5-hydroxyindolacetic acid in urine increased 42.19 9.58 20 268556 227 70659641
Peripheral swelling 42.07 9.58 636 267940 235927 70423941
Cytokine release syndrome 41.93 9.58 24 268552 26443 70633425
Supraventricular extrasystoles 41.58 9.58 80 268496 6118 70653750
Emotional distress 41.52 9.58 262 268314 36926 70622942
Arteriosclerosis 41.42 9.58 148 268428 16490 70643378
Blood mercury abnormal 41.08 9.58 19 268557 203 70659665
Live birth 40.61 9.58 3 268573 13776 70646092
Palpitations 40.29 9.58 616 267960 110137 70549731
Myocardial ischaemia 40.20 9.58 190 268386 24010 70635858
Arteriosclerosis coronary artery 40.16 9.58 144 268432 16071 70643797
Atrioventricular block first degree 40.13 9.58 116 268460 11557 70648311
Neutropenic sepsis 40.08 9.58 22 268554 24808 70635060
Acute myeloid leukaemia 39.88 9.58 35 268541 30905 70628963
Metabolic alkalosis 39.20 9.58 62 268514 4054 70655814
Intentional overdose 38.93 9.58 216 268360 98219 70561649
Septic shock 38.81 9.58 257 268319 112001 70547867
Epstein-Barr virus infection 38.54 9.58 3 268573 13195 70646673
Disease progression 38.07 9.58 394 268182 156278 70503590
Graft versus host disease 37.40 9.58 6 268570 15017 70644851
Pneumocystis jirovecii pneumonia 36.45 9.58 36 268540 30046 70629822
Impaired healing 35.92 9.58 152 268424 74222 70585646
Anhedonia 35.87 9.58 127 268449 14086 70645782
Hypersensitivity 35.53 9.58 634 267942 229178 70430690
Product monitoring error 35.51 9.58 79 268497 6697 70653171
Haemophagocytic lymphohistiocytosis 35.28 9.58 15 268561 19597 70640271
Sedation 35.07 9.58 78 268498 46653 70613215
Mobility decreased 35.00 9.58 237 268339 102762 70557106
Hospitalisation 34.42 9.58 178 268398 82390 70577478
Allergic oedema 34.26 9.58 26 268550 729 70659139
Renal injury 34.13 9.58 136 268440 15958 70643910
Psoriatic arthropathy 34.05 9.58 128 268448 64643 70595225
Actinic keratosis 33.71 9.58 69 268507 5521 70654347
Cardiac murmur 33.47 9.58 112 268464 12074 70647794
Liver disorder 33.46 9.58 120 268456 61448 70598420
Respiratory depression 33.34 9.58 27 268549 24804 70635064
Multiple organ dysfunction syndrome 33.34 9.58 257 268319 108258 70551610
Lymphocyte count decreased 33.23 9.58 72 268504 43467 70616401
Systemic infection 33.09 9.58 76 268500 6581 70653287
Choroidal effusion 32.95 9.58 24 268552 631 70659237
Cataract 32.95 9.58 339 268237 55306 70604562
Fear 32.84 9.58 161 268415 20650 70639218
Bradycardia 32.72 9.58 658 267918 123957 70535911
Eosinophilic bronchitis 32.49 9.58 20 268556 394 70659474
Neurotoxicity 32.48 9.58 39 268537 29787 70630081
Dystonia 32.48 9.58 17 268559 19689 70640179
Cardiac disorder 32.39 9.58 356 268220 59059 70600809
Epilepsy 32.28 9.58 61 268515 38723 70621145
Infective pulmonary exacerbation of cystic fibrosis 32.27 9.58 4 268572 12154 70647714
Nausea 32.21 9.58 3690 264886 848398 69811470
Vertigo 32.18 9.58 371 268205 62272 70597596
Bronchomalacia 31.98 9.58 16 268560 206 70659662
Sedation complication 31.97 9.58 6 268570 13404 70646464
Adverse drug reaction 31.71 9.58 100 268476 53244 70606624
Aspergillus infection 31.61 9.58 14 268562 17854 70642014
Hypophagia 31.52 9.58 267 268309 41303 70618565
Schizophrenia 31.51 9.58 12 268564 16756 70643112
Disseminated intravascular coagulation 31.48 9.58 49 268527 33549 70626319
Large intestine polyp 31.10 9.58 105 268471 11371 70648497
Pulmonary valve disease 30.84 9.58 17 268559 270 70659598
White blood cell count decreased 30.73 9.58 456 268120 169685 70490183
Bacteraemia 30.17 9.58 40 268536 29269 70630599
Rash 29.99 9.58 1604 266972 508958 70150910
Essential hypertension 29.94 9.58 65 268511 5419 70654449
Pericardial disease 29.86 9.58 21 268555 522 70659346
Granulomatous pneumonitis 29.85 9.58 12 268564 88 70659780
Transplant rejection 29.47 9.58 16 268560 18155 70641713
Product prescribing error 29.43 9.58 250 268326 38702 70621166
Hypertensive heart disease 29.34 9.58 53 268523 3863 70656005
Weight decreased 29.07 9.58 1446 267130 309042 70350826
C-reactive protein increased 28.91 9.58 273 268303 110244 70549624
Disorientation 28.84 9.58 341 268235 57582 70602286
Haematotoxicity 28.84 9.58 8 268568 13666 70646202
Dysgeusia 28.56 9.58 300 268276 49202 70610666
Intestinal villi atrophy 28.32 9.58 18 268558 376 70659492
Polydipsia 28.27 9.58 67 268509 5921 70653947
Hip arthroplasty 28.12 9.58 39 268537 28001 70631867
Photosensitivity reaction 27.98 9.58 146 268430 19194 70640674
Myalgia 27.93 9.58 833 267743 167059 70492809
Ventricular extrasystoles 27.35 9.58 139 268437 18087 70641781
Left ventricular hypertrophy 27.34 9.58 93 268483 10109 70649759
Kidney transplant rejection 27.13 9.58 3 268573 9958 70649910
Vascular purpura 27.03 9.58 42 268534 2704 70657164
Overdose 26.96 9.58 466 268110 169279 70490589
Immune reconstitution inflammatory syndrome 26.66 9.58 8 268568 12982 70646886
Aggression 26.61 9.58 94 268482 48352 70611516
Electrocardiogram ST segment depression 26.57 9.58 55 268521 4436 70655432
Pernicious anaemia 26.53 9.58 20 268556 555 70659313
Injury 26.52 9.58 370 268206 64875 70594993
Cutaneous T-cell lymphoma 26.48 9.58 40 268536 2513 70657355
Premature delivery 26.39 9.58 25 268551 21279 70638589
Extrasystoles 26.28 9.58 71 268505 6803 70653065
Tricuspid valve incompetence 26.12 9.58 135 268441 17682 70642186
Drug ineffective for unapproved indication 26.01 9.58 68 268508 38470 70621398
Atrioventricular block 25.93 9.58 106 268470 12582 70647286
Nasopharyngitis 25.83 9.58 642 267934 221564 70438304
Ill-defined disorder 25.74 9.58 113 268463 54628 70605240
Gout 25.63 9.58 162 268414 22844 70637024
Myelodysplastic syndrome 25.54 9.58 46 268530 29739 70630129
Peripheral vascular disorder 25.43 9.58 75 268501 7557 70652311
Interstitial granulomatous dermatitis 25.36 9.58 14 268562 223 70659645
Venoocclusive liver disease 24.98 9.58 5 268571 10673 70649195
Myopathy 24.55 9.58 137 268439 18475 70641393
Erectile dysfunction 24.40 9.58 109 268467 13453 70646415
Microalbuminuria 24.35 9.58 23 268553 876 70658992
Muscle spasms 23.94 9.58 758 267818 153288 70506580
Anti-neutrophil cytoplasmic antibody positive vasculitis 23.91 9.58 44 268532 3253 70656615
Hypogammaglobulinaemia 23.87 9.58 7 268569 11531 70648337
Toxic epidermal necrolysis 23.62 9.58 74 268502 39483 70620385
Polyuria 23.56 9.58 107 268469 13299 70646569
Low density lipoprotein decreased 23.41 9.58 25 268551 1105 70658763
Rotator cuff syndrome 23.40 9.58 103 268473 12631 70647237
Tendon rupture 23.37 9.58 94 268482 11075 70648793
Renal artery stent placement 23.32 9.58 8 268568 35 70659833
Thrombotic microangiopathy 23.24 9.58 20 268556 17828 70642040
Dilatation atrial 23.16 9.58 45 268531 3467 70656401
Physical examination abnormal 22.96 9.58 14 268562 271 70659597
Blood pressure decreased 22.96 9.58 480 268096 91035 70568833
Device related thrombosis 22.76 9.58 36 268540 2354 70657514
Bladder prolapse 22.74 9.58 26 268550 1241 70658627
Fluid intake reduced 22.54 9.58 59 268517 5548 70654320
Depressed level of consciousness 22.42 9.58 217 268359 87214 70572654
Mydriasis 22.40 9.58 17 268559 16136 70643732
Diverticulum 22.38 9.58 107 268469 13586 70646282
Device related infection 22.33 9.58 56 268520 32129 70627739
Mental status changes 22.19 9.58 349 268227 62752 70597116
Gastrointestinal disorder 22.12 9.58 274 268302 105153 70554715
Lacunar infarction 21.94 9.58 59 268517 5637 70654231
Liver function test increased 21.88 9.58 61 268515 33786 70626082
Cytopenia 21.84 9.58 20 268556 17303 70642565
Hyperammonaemia 21.75 9.58 6 268570 10287 70649581
Mucosal inflammation 21.64 9.58 159 268417 67691 70592177
Depression 21.46 9.58 940 267636 198034 70461834
IgM nephropathy 21.40 9.58 8 268568 47 70659821
Coronary artery occlusion 21.24 9.58 109 268467 14236 70645632
Bundle branch block right 21.18 9.58 88 268488 10522 70649346
Multiple drug therapy 21.17 9.58 41 268535 3151 70656717
Pancreatitis necrotising 21.16 9.58 42 268534 3286 70656582
Diastolic dysfunction 21.04 9.58 81 268495 9352 70650516
Non-cardiogenic pulmonary oedema 20.99 9.58 26 268550 1351 70658517
Acute coronary syndrome 20.90 9.58 139 268437 19940 70639928
Occult blood 20.86 9.58 27 268549 1467 70658401
Basal cell carcinoma 20.76 9.58 207 268369 33491 70626377
Gastric disorder 20.68 9.58 205 268371 33117 70626751
Neurosensory hypoacusis 20.64 9.58 12 268564 212 70659656
Pollakiuria 20.35 9.58 205 268371 33256 70626612
Low density lipoprotein increased 20.29 9.58 72 268504 7993 70651875
Respiratory failure 20.29 9.58 485 268091 168250 70491618
Therapy partial responder 20.21 9.58 11 268565 12463 70647405
Gait disturbance 20.08 9.58 875 267701 184231 70475637
Pain 20.06 9.58 2080 266496 626736 70033132
Hyperhidrosis 19.79 9.58 645 267931 130941 70528927
Bone erosion 19.76 9.58 17 268559 15156 70644712
Colorectal cancer 19.75 9.58 4 268572 8466 70651402
Blood creatine phosphokinase increased 19.74 9.58 334 268242 60929 70598939
Pathogen resistance 19.70 9.58 13 268563 13266 70646602
Nervousness 19.58 9.58 192 268384 30928 70628940
Acute respiratory distress syndrome 19.49 9.58 85 268491 41169 70618699
Acquired acrodermatitis enteropathica 19.45 9.58 5 268571 5 70659863
Product quality issue 19.45 9.58 189 268387 30372 70629496
Encephalitis 19.22 9.58 14 268562 13571 70646297
Injection site inflammation 19.06 9.58 41 268535 3397 70656471
Drug hypersensitivity 19.05 9.58 806 267770 261653 70398215
Osteoarthritis 18.95 9.58 390 268186 73757 70586111
Uveitis 18.88 9.58 17 268559 14828 70645040
Tooth erosion 18.78 9.58 14 268562 382 70659486
Diverticulitis 18.75 9.58 241 268335 41493 70618375
Renal tubular necrosis 18.73 9.58 151 268425 23020 70636848
Lymphopenia 18.68 9.58 48 268528 27311 70632557
Coronary artery bypass 18.61 9.58 57 268519 5863 70654005
Renovascular hypertension 18.60 9.58 7 268569 42 70659826
Peritonitis 18.55 9.58 45 268531 26114 70633754
Accidental exposure to product 18.55 9.58 50 268526 28001 70631867
Substance abuse 18.55 9.58 7 268569 9830 70650038
Osteonecrosis of jaw 18.46 9.58 86 268490 40916 70618952
Atrioventricular block second degree 18.35 9.58 62 268514 6716 70653152
Gangrene 18.25 9.58 71 268505 8238 70651630
Respiratory tract inflammation 18.24 9.58 19 268557 816 70659052
Meniscus injury 18.12 9.58 58 268518 6109 70653759
Electrocardiogram abnormal 18.07 9.58 106 268470 14558 70645310
Oropharyngeal swelling 18.07 9.58 23 268553 1229 70658639
Aplastic anaemia 18.05 9.58 22 268554 16694 70643174
Muscle necrosis 17.98 9.58 24 268552 1344 70658524
Pleural effusion 17.93 9.58 375 268201 132489 70527379
COVID-19 17.87 9.58 287 268289 105470 70554398
Colitis ulcerative 17.85 9.58 67 268509 33856 70626012
Polymyalgia rheumatica 17.83 9.58 43 268533 3843 70656025
Meniere's disease 17.80 9.58 10 268566 165 70659703
Pharyngeal oedema 17.78 9.58 111 268465 15585 70644283
Cell death 17.71 9.58 45 268531 4155 70655713
Blood uric acid increased 17.66 9.58 75 268501 9054 70650814
Angle closure glaucoma 17.59 9.58 35 268541 2744 70657124
Heart rate irregular 17.51 9.58 181 268395 29562 70630306
Cholelithiasis 17.47 9.58 264 268312 47076 70612792
Orthostatic hypotension 17.37 9.58 284 268292 51459 70608409
Sinusitis 17.26 9.58 498 268078 168697 70491171
Progressive multifocal leukoencephalopathy 17.08 9.58 29 268547 19185 70640683
Breast neoplasm 17.02 9.58 19 268557 883 70658985
Psychotic disorder 17.02 9.58 79 268497 37622 70622246
Akathisia 16.97 9.58 13 268563 12280 70647588
Blood creatine increased 16.96 9.58 72 268504 8692 70651176
Blood triglycerides increased 16.91 9.58 130 268446 19534 70640334
Renal function test abnormal 16.86 9.58 44 268532 4130 70655738
Hepatic steatosis 16.80 9.58 199 268377 33614 70626254
Allergic cough 16.72 9.58 15 268561 534 70659334
Cystitis haemorrhagic 16.40 9.58 6 268570 8587 70651281
Hypoxia 16.22 9.58 252 268324 93092 70566776
Hypertensive angiopathy 16.20 9.58 8 268568 100 70659768
Intervertebral disc degeneration 16.18 9.58 99 268477 13801 70646067
Suicide attempt 16.17 9.58 208 268368 79302 70580566
Lichen planus 16.13 9.58 32 268544 2503 70657365
Colitis 16.10 9.58 159 268417 63655 70596213
Nephrocalcinosis 16.04 9.58 23 268553 1378 70658490
Clostridium difficile infection 15.99 9.58 84 268492 38732 70621136
Pulmonary arterial hypertension 15.95 9.58 67 268509 32788 70627080
Carpal tunnel syndrome 15.94 9.58 115 268461 16942 70642926
Cardiovascular disorder 15.93 9.58 113 268463 16557 70643311
Rectal prolapse 15.89 9.58 28 268548 2001 70657867
Fear of injection 15.87 9.58 3 268573 6669 70653199
Fibromyalgia 15.84 9.58 111 268465 47763 70612105
Cutaneous lupus erythematosus 15.83 9.58 34 268542 2814 70657054
Mandibular mass 15.77 9.58 10 268566 208 70659660
Paradoxical drug reaction 15.75 9.58 3 268573 6633 70653235
Seizure 15.68 9.58 534 268042 177428 70482440
Choroidal detachment 15.67 9.58 15 268561 581 70659287
Erythrodermic psoriasis 15.53 9.58 25 268551 1659 70658209
Neurofibrosarcoma 15.52 9.58 10 268566 214 70659654
Mouth ulceration 15.49 9.58 72 268504 34277 70625591
Endometrial cancer stage I 15.38 9.58 9 268567 161 70659707
Musculoskeletal stiffness 15.30 9.58 434 268142 147326 70512542
Troponin I increased 15.27 9.58 42 268534 4066 70655802
Spinal osteoarthritis 15.23 9.58 105 268471 15243 70644625
Jaw disorder 15.21 9.58 46 268530 4700 70655168
Renin increased 15.20 9.58 10 268566 222 70659646
Torsade de pointes 15.16 9.58 119 268457 17997 70641871
Thalamic infarction 15.15 9.58 21 268555 1219 70658649
Squamous cell carcinoma 15.14 9.58 101 268475 14503 70645365
Shoshin beriberi 15.12 9.58 7 268569 75 70659793
Hemiparesis 15.11 9.58 184 268392 31285 70628583
Withdrawal hypertension 15.09 9.58 12 268564 361 70659507
Mucosal membrane hyperplasia 15.04 9.58 6 268570 43 70659825
Eosinophilia 14.94 9.58 225 268351 40094 70619774
Poisoning deliberate 14.94 9.58 26 268550 17034 70642834
Drug-induced liver injury 14.93 9.58 138 268438 55975 70603893
Disability 14.87 9.58 21 268555 14962 70644906
Aortic valve incompetence 14.86 9.58 70 268506 8834 70651034
Pseudomonas infection 14.84 9.58 31 268545 18963 70640905
Body temperature decreased 14.81 9.58 170 268406 28502 70631366
Hip fracture 14.79 9.58 168 268408 28095 70631773
Trigger finger 14.76 9.58 39 268537 3688 70656180
Blood osmolarity decreased 14.75 9.58 21 268555 1250 70658618
Polyp 14.73 9.58 60 268516 7110 70652758
Gouty arthritis 14.71 9.58 22 268554 1370 70658498
Lymphangiectasia intestinal 14.68 9.58 4 268572 6 70659862
Liver injury 14.65 9.58 93 268483 40942 70618926
Alkalosis hypochloraemic 14.65 9.58 13 268563 456 70659412
Carcinoid tumour of the gastrointestinal tract 14.65 9.58 7 268569 81 70659787
Agitation 14.60 9.58 257 268319 93118 70566750
Renal artery angioplasty 14.55 9.58 5 268571 22 70659846
Lipohypertrophy 14.53 9.58 17 268559 832 70659036
Shock hypoglycaemic 14.52 9.58 10 268566 240 70659628
Nodular rash 14.48 9.58 11 268565 309 70659559
Blood hyposmosis 14.37 9.58 5 268571 23 70659845
Enterocolitis 14.32 9.58 17 268559 13049 70646819
Laryngeal pain 14.30 9.58 51 268525 5677 70654191
Electrocardiogram U-wave abnormality 14.28 9.58 7 268569 86 70659782
Anxiety 14.27 9.58 993 267583 219337 70440531
Hypocalcaemia 14.25 9.58 244 268332 44615 70615253
Hepatic neoplasm 14.24 9.58 35 268541 3165 70656703
High density lipoprotein decreased 14.23 9.58 41 268535 4078 70655790
Tumour lysis syndrome 14.18 9.58 38 268538 21322 70638546
Rhinovirus infection 14.09 9.58 4 268572 6729 70653139
Agranulocytosis 14.05 9.58 92 268484 40206 70619662
Tooth abscess 14.00 9.58 99 268477 14490 70645378
Distributive shock 13.95 9.58 28 268548 2209 70657659
Enterococcal infection 13.92 9.58 21 268555 14561 70645307
Echocardiogram abnormal 13.84 9.58 26 268550 1953 70657915
Gastrointestinal angiodysplasia 13.83 9.58 18 268558 983 70658885
Lymphomatoid papulosis 13.83 9.58 11 268565 331 70659537
Pruritus allergic 13.81 9.58 19 268557 1095 70658773
Dysuria 13.79 9.58 247 268329 45547 70614321
Miosis 13.76 9.58 20 268556 14081 70645787
Carotid bruit 13.72 9.58 15 268561 681 70659187
Intestinal intraepithelial lymphocytes increased 13.64 9.58 4 268572 9 70659859
Electrocardiogram T wave amplitude decreased 13.61 9.58 14 268562 592 70659276
Angiopathy 13.53 9.58 55 268521 6512 70653356
Preternatural anus 13.48 9.58 7 268569 98 70659770
Intentional product misuse 13.45 9.58 216 268360 79379 70580489
International normalised ratio decreased 13.45 9.58 61 268515 7577 70652291
Diabetes mellitus inadequate control 13.42 9.58 138 268438 22507 70637361
Eosinophilia myalgia syndrome 13.35 9.58 4 268572 10 70659858
Intervertebral disc displacement 13.27 9.58 12 268564 432 70659436
Adenocarcinoma 13.24 9.58 37 268539 3616 70656252
Allergic hepatitis 13.15 9.58 5 268571 31 70659837
Metabolic syndrome 13.13 9.58 29 268547 2446 70657422
Cardiac discomfort 13.08 9.58 19 268557 1152 70658716
Pulpitis dental 13.04 9.58 18 268558 1041 70658827
Recalled product 13.03 9.58 17 268559 931 70658937
Nephropathy 13.03 9.58 67 268509 8758 70651110
Rhinalgia 12.92 9.58 20 268556 1284 70658584
Endometrial hyperplasia 12.91 9.58 13 268563 536 70659332
Renal artery restenosis 12.82 9.58 4 268572 12 70659856
Febrile bone marrow aplasia 12.72 9.58 16 268560 11975 70647893
Neoplasm 12.68 9.58 61 268515 7763 70652105
Cerebral ischaemia 12.66 9.58 75 268501 10337 70649531
Renal artery arteriosclerosis 12.64 9.58 5 268571 35 70659833
Lung disorder 12.61 9.58 186 268390 69298 70590570
Renin decreased 12.54 9.58 7 268569 114 70659754
Hyponatraemic encephalopathy 12.54 9.58 10 268566 302 70659566
Foetal death 12.52 9.58 4 268572 6235 70653633
Small cell carcinoma 12.51 9.58 10 268566 303 70659565
Deep vein thrombosis 12.50 9.58 527 268049 110515 70549353
CD4/CD8 ratio increased 12.36 9.58 4 268572 14 70659854
Device expulsion 12.33 9.58 43 268533 22203 70637665
Intervertebral disc protrusion 12.25 9.58 130 268446 21373 70638495
Vestibular neuronitis 12.20 9.58 14 268562 671 70659197
Metastases to fallopian tube 12.17 9.58 5 268571 39 70659829
Body height decreased 12.13 9.58 60 268516 7723 70652145
Drug use disorder 12.06 9.58 8 268568 8143 70651725
Neuroleptic malignant syndrome 12.04 9.58 54 268522 25953 70633915
Bacterial sepsis 12.02 9.58 7 268569 7640 70652228
Flank pain 12.01 9.58 110 268466 17392 70642476
Cyanopsia 12.01 9.58 6 268570 77 70659791
Paresis cranial nerve 11.96 9.58 5 268571 41 70659827
Haemorrhagic stroke 11.96 9.58 73 268503 10169 70649699
Pulmonary alveolar haemorrhage 11.90 9.58 13 268563 10356 70649512
Mesenteric panniculitis 11.84 9.58 9 268567 253 70659615
Anaphylactic reaction 11.84 9.58 206 268370 74768 70585100
COVID-19 pneumonia 11.82 9.58 43 268533 21926 70637942
Ischaemic stroke 11.81 9.58 173 268403 30647 70629221
Crystal arthropathy 11.80 9.58 8 268568 187 70659681
Delirium 11.78 9.58 205 268371 74409 70585459
Aortic stenosis 11.77 9.58 53 268523 6563 70653305
Hemiataxia 11.75 9.58 5 268571 43 70659825
Carcinogenicity 11.74 9.58 6 268570 81 70659787
Osteitis deformans 11.69 9.58 8 268568 190 70659678
Homans' sign 11.67 9.58 3 268573 3 70659865
Renal artery dissection 11.67 9.58 3 268573 3 70659865
Non-cardiac chest pain 11.65 9.58 66 268510 8949 70650919
Haemolysis 11.65 9.58 16 268560 11535 70648333
Premature labour 11.64 9.58 8 268568 7992 70651876
Pathological fracture 11.63 9.58 69 268507 9514 70650354
Glomerulonephritis rapidly progressive 11.62 9.58 20 268556 1403 70658465
Hyperglycaemia 11.60 9.58 324 268252 64348 70595520
Pseudolymphoma 11.59 9.58 17 268559 1040 70658828
Chronic kidney disease 11.55 9.58 308 268268 60749 70599119
Hepatitis B reactivation 11.55 9.58 3 268573 5352 70654516
Atrophy 11.54 9.58 24 268552 1942 70657926
Accelerated hypertension 11.53 9.58 13 268563 611 70659257
Sleep apnoea syndrome 11.52 9.58 181 268395 32532 70627336
Peripheral circulatory failure 11.52 9.58 17 268559 1046 70658822
Breast cancer stage II 11.52 9.58 3 268573 5343 70654525
Electrocardiogram Q waves 11.49 9.58 6 268570 85 70659783
Coronary artery restenosis 11.46 9.58 19 268557 1293 70658575
Serotonin syndrome 11.45 9.58 103 268473 42011 70617857
Fibrous histiocytoma 11.44 9.58 13 268563 616 70659252
Paraesthesia 11.44 9.58 667 267909 144870 70514998
Pneumatosis intestinalis 11.42 9.58 4 268572 5883 70653985
Wrong technique in product usage process 11.42 9.58 187 268389 68511 70591357
Immunosuppressant drug level increased 11.38 9.58 8 268568 7899 70651969
Haemodialysis 11.35 9.58 108 268468 17258 70642610
Cardiac stress test abnormal 11.31 9.58 14 268562 727 70659141
Oesophageal discomfort 11.31 9.58 9 268567 271 70659597
Diabetes mellitus 11.30 9.58 354 268222 71470 70588398
Ischaemic cardiomyopathy 11.24 9.58 55 268521 7049 70652819
Diabetic neuropathy 11.24 9.58 48 268528 5810 70654058
Skin exfoliation 11.21 9.58 252 268324 48374 70611494
Pulmonary tuberculosis 11.21 9.58 8 268568 7837 70652031
Aortic valve sclerosis 11.19 9.58 21 268555 1576 70658292
Nail bed inflammation 11.17 9.58 12 268564 534 70659334
Coronary artery stenosis 11.17 9.58 79 268497 11565 70648303
Gastrointestinal mucosal necrosis 11.16 9.58 8 268568 205 70659663
Supraventricular tachycardia 11.16 9.58 119 268457 19591 70640277
Parotitis 11.15 9.58 26 268550 2273 70657595
Thirst decreased 11.11 9.58 9 268567 278 70659590
Aortic arteriosclerosis 11.10 9.58 59 268517 7810 70652058
Prescribed overdose 11.10 9.58 59 268517 27122 70632746
Herpes zoster 11.08 9.58 242 268334 84993 70574875
Staring 11.08 9.58 27 268549 2429 70657439
Diffuse large B-cell lymphoma 11.00 9.58 21 268555 13281 70646587
Depressive symptom 10.99 9.58 3 268573 5178 70654690
Swelling face 10.93 9.58 315 268261 62849 70597019
Nodal arrhythmia 10.90 9.58 23 268553 1880 70657988
Confabulation 10.82 9.58 11 268565 459 70659409
Renal arteriosclerosis 10.82 9.58 9 268567 289 70659579
Foreign body in reproductive tract 10.80 9.58 11 268565 460 70659408
Acute hepatic failure 10.78 9.58 61 268515 27611 70632257
Shock 10.78 9.58 214 268362 40211 70619657
Asphyxia 10.76 9.58 14 268562 10328 70649540
Hepatocellular injury 10.74 9.58 117 268459 45974 70613894
Ventricular fibrillation 10.72 9.58 153 268423 26958 70632910
Device use error 10.71 9.58 6 268570 6690 70653178
Post-anoxic myoclonus 10.68 9.58 5 268571 55 70659813
Hypoparathyroidism 10.68 9.58 16 268560 998 70658870
Diverticulum oesophageal 10.66 9.58 7 268569 155 70659713
Blood growth hormone increased 10.66 9.58 13 268563 665 70659203
Helicobacter gastritis 10.63 9.58 26 268550 2345 70657523
Klebsiella infection 10.61 9.58 24 268552 14268 70645600
Aspiration 10.60 9.58 33 268543 17642 70642226
Haematocrit decreased 10.59 9.58 288 268288 56970 70602898
Ventricular arrhythmia 10.57 9.58 58 268518 7772 70652096
Gallbladder disorder 10.53 9.58 108 268468 17604 70642264
Product commingling 10.53 9.58 6 268570 102 70659766
Hypervitaminosis D 10.53 9.58 6 268570 102 70659766
Fine motor skill dysfunction 10.48 9.58 3 268573 5021 70654847
Device issue 10.46 9.58 51 268525 23974 70635894
Vascular device infection 10.45 9.58 9 268567 8021 70651847
Adiposis dolorosa 10.43 9.58 9 268567 304 70659564
Staphylococcal sepsis 10.42 9.58 22 268554 13405 70646463
Blood lactate dehydrogenase increased 10.41 9.58 84 268492 35043 70624825
Cardiac arrest 10.33 9.58 497 268079 159337 70500531
Spinal cord infarction 10.33 9.58 12 268564 583 70659285
Hypovitaminosis 10.31 9.58 16 268560 1029 70658839
Depressed mood 10.31 9.58 111 268465 43709 70616159
Skin turgor decreased 10.31 9.58 13 268563 688 70659180
Abdominal tenderness 10.30 9.58 68 268508 9732 70650136
Osmotic demyelination syndrome 10.29 9.58 18 268558 1279 70658589
Electrocardiogram ST-T change 10.28 9.58 20 268556 1542 70658326
Renal cyst 10.26 9.58 86 268490 13259 70646609
Macrocytosis 10.26 9.58 28 268548 2699 70657169
Erythema 10.22 9.58 635 267941 198928 70460940
Product residue present 10.18 9.58 32 268544 3338 70656530
Sciatic nerve injury 10.18 9.58 11 268565 493 70659375
Bladder irrigation 10.16 9.58 5 268571 62 70659806
Status epilepticus 10.15 9.58 53 268523 24473 70635395
Brain stem infarction 10.14 9.58 22 268554 1833 70658035
QRS axis abnormal 10.13 9.58 22 268554 1835 70658033
Iatrogenic injury 10.12 9.58 19 268557 1426 70658442
Hyperparathyroidism primary 10.12 9.58 10 268566 403 70659465
Heart rate decreased 10.11 9.58 307 268269 61708 70598160
Hypercholesterolaemia 10.08 9.58 109 268467 18008 70641860
Electrocardiogram ST segment elevation 10.05 9.58 56 268520 7548 70652320
Coordination abnormal 10.05 9.58 99 268477 15967 70643901
Labyrinthitis 10.02 9.58 28 268548 2736 70657132
Haemarthrosis 10.00 9.58 44 268532 5395 70654473
Wound treatment 9.99 9.58 7 268569 173 70659695
Dementia 9.98 9.58 129 268447 22236 70637632
Ankylosing spondylitis 9.97 9.58 18 268558 11628 70648240
Rales 9.95 9.58 104 268472 17031 70642837
Aortic valve calcification 9.95 9.58 13 268563 713 70659155
Mitral valve disease 9.90 9.58 29 268547 2911 70656957
Endometrial disorder 9.89 9.58 11 268565 509 70659359
Nodal rhythm 9.89 9.58 29 268547 2912 70656956
Epileptic encephalopathy 9.88 9.58 10 268566 415 70659453
Gastrointestinal toxicity 9.87 9.58 6 268570 6399 70653469
Encephalopathy 9.87 9.58 169 268407 61492 70598376
Forced vital capacity decreased 9.87 9.58 20 268556 1589 70658279
Feeling abnormal 9.84 9.58 645 267931 141674 70518194
Amnesia 9.84 9.58 263 268313 51892 70607976
Abdominoplasty 9.82 9.58 5 268571 67 70659801
Gastrointestinal tract mucosal pigmentation 9.79 9.58 15 268561 954 70658914
Haemorrhagic fever 9.76 9.58 4 268572 31 70659837
Neuroglycopenia 9.76 9.58 10 268566 421 70659447
Muscular weakness 9.75 9.58 628 267948 137708 70522160
Pneumothorax spontaneous 9.74 9.58 18 268558 1335 70658533
Cachexia 9.70 9.58 14 268562 9886 70649982
Asymptomatic bacteriuria 9.70 9.58 9 268567 335 70659533
Expired product administered 9.68 9.58 49 268527 6364 70653504
Pituitary apoplexy 9.68 9.58 7 268569 182 70659686
Injection site hypersensitivity 9.67 9.58 21 268555 1751 70658117
Macular degeneration 9.66 9.58 55 268521 7473 70652395
Urinary incontinence 9.65 9.58 199 268377 37643 70622225
Activated partial thromboplastin time 9.65 9.58 4 268572 32 70659836
Visual acuity reduced 9.64 9.58 154 268422 27776 70632092
Vision blurred 9.63 9.58 446 268130 94538 70565330
Coronary arterial stent insertion 9.62 9.58 46 268530 5841 70654027
Drug reaction with eosinophilia and systemic symptoms 9.61 9.58 158 268418 57855 70602013
Grip strength decreased 9.61 9.58 29 268547 15656 70644212
Ascites 9.60 9.58 189 268387 67358 70592510
Aplasia 9.59 9.58 8 268568 7243 70652625
Amaurosis fugax 9.59 9.58 14 268562 853 70659015

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03AA03 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, plain
ATC C03AB03 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides and potassium in combination
ATC C03AX01 CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, combinations with other drugs
ATC C03EA01 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Low-ceiling diuretics and potassium-sparing agents
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09DX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09XA52 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C09XA54 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
FDA CS M0471776 Thiazides
FDA PE N0000175359 Increased Diuresis
FDA EPC N0000175419 Thiazide Diuretic
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049993 Sodium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35498 diuretics
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Edema indication 267038008
Hypertensive urgency indication 443482000
Pulmonary Edema due to Chronic Heart Failure indication
Edema due to Hepatic Cirrhosis indication
Peripheral Edema due to Chronic Heart Failure indication
Edema due to Nephrotic Syndrome indication
Hypertension with Left Ventricular Hypertrophy indication
Nephrogenic diabetes insipidus off-label use 111395007 DOID:12387
Calcium renal calculus off-label use 427649000
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Suicidal thoughts contraindication 6471006
Psoriasis contraindication 9014002 DOID:8893
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Chronic disease of respiratory system contraindication 17097001
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Jaundice contraindication 18165001
Cirrhosis of liver contraindication 19943007 DOID:5082
Secondary angle-closure glaucoma contraindication 21571006
Electroconvulsive therapy contraindication 23835007
Acute vomiting contraindication 23971007
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Acute cerebrovascular insufficiency contraindication 29322000
Obstruction of bile duct contraindication 30144000
Parkinsonism contraindication 32798002
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Acute hepatitis contraindication 37871000
Immunosuppression contraindication 38013005
Anaphylaxis contraindication 39579001
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Sinus bradycardia contraindication 49710005
Cough contraindication 49727002
Acidosis contraindication 51387008
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Aortic valve stenosis contraindication 60573004 DOID:1712
Chronic bronchitis contraindication 63480004 DOID:6132
Ulcerative colitis contraindication 64766004 DOID:8577
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Benign intracranial hypertension contraindication 68267002 DOID:11459
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Oliguria contraindication 83128009
Epilepsy contraindication 84757009 DOID:1826
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Kidney stone contraindication 95570007
Disorder of connective tissue contraindication 105969002 DOID:65
Diabetic renal disease contraindication 127013003
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Angina pectoris contraindication 194828000
Partial atrioventricular block contraindication 195039008
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Asthma contraindication 195967001 DOID:2841
Acute hepatic failure contraindication 197270009
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Disorder of electrolytes contraindication 237840007
Lupus erythematosus and erythema multiforme-like syndrome contraindication 238926009
Rhabdomyolysis contraindication 240131006
Raynaud's phenomenon contraindication 266261006
Calculus in biliary tract contraindication 266474003
Anemia contraindication 271737000 DOID:2355
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Pheochromocytoma contraindication 302835009
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Severe chronic obstructive pulmonary disease contraindication 313299006
Right ventricular failure contraindication 367363000
Surgical procedure contraindication 387713003
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Severe diarrhea contraindication 409587002
Autoimmune hemolytic anemia contraindication 413603009 DOID:718
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Porphyria contraindication 418470004
Intraoperative floppy iris syndrome contraindication 418801006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005
Azotemia contraindication 445009001
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
First Degree Atrioventricular Heart Block contraindication
Severe Aortic Valve Stenosis contraindication
Head and Neck Angioedema contraindication
Severe Cerebrovascular Disease contraindication
Intestinal Angioedema contraindication
Hemodialysis with High-Flux Membrane contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle Postparturient udder edema Indication

🐶 Veterinary products

ProductApplicantIngredients
Hydrozide Injection Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.89 acidic
pKa2 11.02 acidic
pKa3 0.71 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 12 member 3 Transporter INHIBITOR A2 7.01 WOMBAT-PK CHEMBL
Carbonic anhydrase 1 Enzyme Ki 6.48 CHEMBL
Carbonic anhydrase 4 Enzyme WOMBAT-PK
Calcium-activated potassium channel subunit alpha-1 Ion channel WOMBAT-PK
Carbonic anhydrase 2 Enzyme Ki 5.90 WOMBAT-PK
Astrosclerin-3 Enzyme Ki 6.40 CHEMBL
Delta carbonic anhydrase Unclassified Ki 5.37 CHEMBL
Carbonic anhydrase Enzyme Ki 7.50 CHEMBL
Carbonic anhydrase, alpha family Unclassified Ki 6.53 CHEMBL
Carbonate dehydratase Enzyme Ki 8.14 CHEMBL

External reference:

IDSource
4017615 VUID
N0000145995 NUI
D00340 KEGG_DRUG
4017615 VANDF
C0020261 UMLSCUI
CHEBI:5778 CHEBI
HCZ PDB_CHEM_ID
CHEMBL435 ChEMBL_ID
CHEMBL43686 ChEMBL_ID
CHEMBL15605 ChEMBL_ID
DB00999 DRUGBANK_ID
D006852 MESH_DESCRIPTOR_UI
3639 PUBCHEM_CID
4836 IUPHAR_LIGAND_ID
841 INN_ID
0J48LPH2TH UNII
5487 RXNORM
4834 MMSL
924 MMSL
d00253 MMSL
002294 NDDF
387525002 SNOMEDCT_US
91667005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5855 TABLET, FILM COATED 12.50 mg ORAL NDA 30 sections
Avalide HUMAN PRESCRIPTION DRUG LABEL 2 0024-5856 TABLET, FILM COATED 12.50 mg ORAL NDA 30 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1011 TABLET, FILM COATED 25 mg ORAL NDA 24 sections
ALDACTAZIDE HUMAN PRESCRIPTION DRUG LABEL 2 0025-1021 TABLET, FILM COATED 50 mg ORAL NDA 24 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0254 TABLET 12.50 mg ORAL ANDA 28 sections
Irbesartan and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0255 TABLET 12.50 mg ORAL ANDA 28 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0545 TABLET 12.50 mg ORAL NDA authorized generic 27 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0546 TABLET 12.50 mg ORAL NDA authorized generic 27 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0547 TABLET 25 mg ORAL NDA authorized generic 27 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-0220 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-0222 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-0223 TABLET, FILM COATED 25 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-3112 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-5212 TABLET, FILM COATED 12.50 mg ORAL NDA 22 sections
ACCURETIC HUMAN PRESCRIPTION DRUG LABEL 2 0071-7225 TABLET, FILM COATED 25 mg ORAL NDA 22 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0314 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0314 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0315 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0315 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0383 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0383 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0471 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0471 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0472 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Diovan HCT HUMAN PRESCRIPTION DRUG LABEL 2 0078-0472 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0559 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0559 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0560 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0560 TABLET, FILM COATED 25 mg ORAL NDA 31 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0561 TABLET, FILM COATED 12.50 mg ORAL NDA 31 sections