verapamil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, verapamil derivatives 2815 52-53-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • verapamil
  • RS-Verapamil
  • (+/-)-Verapamil
  • verapamil hydrochloride
  • verapamil HCl
A calcium channel blocker that is a class IV anti-arrhythmia agent.
  • Molecular weight: 454.61
  • Formula: C27H38N2O4
  • CLOGP: 4.27
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 63.95
  • ALOGS: -5.06
  • ROTB: 13
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 g O
0.24 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.75 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 22 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 18 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.09 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.80 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 50
kinase-selectivity-class AKT3,AXL,BRAF,EIF2AK3,EPHB4,ERBB2,GRK2,PDK4,PIK3CD,PRKDC,SIK2,TEK,TTK 13
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.396 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 0.196 % High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 12, 1981 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1219.25 12.20 759 37500 144299 90445889
Bradycardia 681.23 12.20 430 37829 83417 90506771
Toxicity to various agents 490.73 12.20 605 37654 287241 90302947
Cardiogenic shock 421.37 12.20 206 38053 24262 90565926
Hypotension 409.97 12.20 590 37669 324807 90265381
Drug interaction 409.39 12.20 542 37717 275911 90314277
Atrioventricular block complete 385.68 12.20 148 38111 9663 90580525
BRASH syndrome 384.60 12.20 100 38159 1779 90588409
Atrioventricular block 242.88 12.20 103 38156 8712 90581476
Metabolic acidosis 202.15 12.20 176 38083 55500 90534688
Overdose 189.37 12.20 280 37979 157429 90432759
Intentional overdose 175.27 12.20 207 38052 93627 90496561
Anuria 167.08 12.20 94 38165 14724 90575464
Neovascularisation 165.01 12.20 50 38209 1580 90588608
Drug ineffective for unapproved indication 126.04 12.20 148 38111 66496 90523692
Synovitis 121.25 12.20 4 38255 329748 90260440
Electrocardiogram QRS complex prolonged 120.88 12.20 60 38199 7288 90582900
Acute respiratory distress syndrome 119.12 12.20 98 38161 28588 90561600
Glossodynia 117.97 12.20 4 38255 321775 90268413
Shock 114.69 12.20 96 38163 28682 90561506
Sinus bradycardia 113.16 12.20 77 38182 16875 90573313
Paradoxical drug reaction 112.75 12.20 53 38206 5713 90584475
Atrioventricular block first degree 112.56 12.20 60 38199 8451 90581737
Systemic lupus erythematosus 110.51 12.20 12 38247 361884 90228304
Infusion related reaction 104.44 12.20 24 38235 416756 90173432
Joint swelling 104.40 12.20 41 38218 503259 90086929
Cardiac arrest 103.13 12.20 170 38089 104765 90485423
Vasoplegia syndrome 98.37 12.20 39 38220 2775 90587413
Electrocardiogram QT prolonged 97.65 12.20 136 38123 72320 90517868
Pericarditis 96.80 12.20 4 38255 270147 90320041
Arthropathy 96.02 12.20 19 38240 366223 90223965
Cryopyrin associated periodic syndrome 91.42 12.20 25 38234 543 90589645
Distributive shock 84.43 12.20 37 38222 3387 90586801
Wound 80.92 12.20 15 38244 302965 90287223
Duodenal ulcer perforation 80.21 12.20 3 38256 221285 90368903
Hyperglycaemia 79.89 12.20 103 38156 50867 90539321
Nodal rhythm 77.10 12.20 29 38230 1789 90588399
Hepatic enzyme increased 77.07 12.20 28 38231 360708 90229480
Extrapyramidal disorder 72.54 12.20 58 38201 16245 90573943
Atrial fibrillation 70.84 12.20 167 38092 133444 90456744
Labelled drug-drug interaction medication error 69.45 12.20 54 38205 14528 90575660
Lower respiratory tract infection 67.81 12.20 12 38247 250647 90339541
Rhythm idioventricular 66.26 12.20 18 38241 381 90589807
Impaired healing 66.06 12.20 10 38249 234189 90355999
Swelling 62.68 12.20 51 38208 419007 90171181
Irritable bowel syndrome 60.51 12.20 8 38251 207440 90382748
Acute kidney injury 59.27 12.20 280 37979 320107 90270081
Therapeutic product effect decreased 58.50 12.20 22 38237 277549 90312639
Fear of disease 57.04 12.20 22 38237 1454 90588734
Type 2 diabetes mellitus 56.58 12.20 9 38250 203235 90386953
Rash 54.08 12.20 165 38094 795935 89794253
Nodal arrhythmia 52.42 12.20 20 38239 1283 90588905
Atrioventricular block second degree 52.24 12.20 29 38230 4423 90585765
Rheumatoid arthritis 51.92 12.20 46 38213 362568 90227620
Cardiac failure congestive 51.90 12.20 123 38136 98571 90491617
Alopecia 51.43 12.20 81 38178 494990 90095198
Liver injury 51.15 12.20 6 38253 170561 90419627
Abdominal discomfort 50.63 12.20 77 38182 477251 90112937
Coma 50.13 12.20 101 38158 72531 90517657
Acute lung injury 49.72 12.20 20 38239 1478 90588710
Bundle branch block right 49.34 12.20 30 38229 5423 90584765
Contraindicated product administered 49.06 12.20 38 38221 320101 90270087
Cardiac failure 47.67 12.20 127 38132 109369 90480819
Discomfort 46.76 12.20 29 38230 274306 90315882
Hyperkalaemia 45.62 12.20 91 38168 64873 90525315
Suicide attempt 45.23 12.20 99 38160 75300 90514888
Rhabdomyolysis 44.99 12.20 79 38180 51177 90539011
Blister 44.80 12.20 26 38233 254972 90335216
Large intestine polyp 43.06 12.20 34 38225 9352 90580836
Blood cholesterol increased 42.96 12.20 17 38242 207995 90382193
Medication overuse headache 42.88 12.20 18 38241 1483 90588705
Joint range of motion decreased 42.65 12.20 4 38255 135639 90454549
Suspected suicide 42.48 12.20 34 38225 9534 90580654
Atrioventricular dissociation 40.89 12.20 11 38248 224 90589964
Arrhythmia 40.78 12.20 68 38191 42264 90547924
Cardio-respiratory arrest 40.27 12.20 85 38174 63055 90527133
Cough 40.18 12.20 280 37979 368682 90221506
Non-cardiogenic pulmonary oedema 39.45 12.20 16 38243 1208 90588980
Mobility decreased 39.38 12.20 29 38230 250705 90339483
Tongue oedema 39.34 12.20 26 38233 5428 90584760
Hypoglobulinaemia 38.93 12.20 10 38249 169 90590019
Drug intolerance 38.65 12.20 82 38177 447509 90142679
Device pacing issue 38.53 12.20 9 38250 100 90590088
Lactic acidosis 38.25 12.20 73 38186 50390 90539798
Myocardial stunning 37.77 12.20 11 38248 302 90589886
Sinus node dysfunction 37.11 12.20 25 38234 5387 90584801
Gastrointestinal disorder 36.20 12.20 33 38226 256654 90333534
Reversible cerebral vasoconstriction syndrome 35.52 12.20 22 38237 4108 90586080
Supraventricular tachycardia 35.48 12.20 39 38220 16297 90573891
Respiratory depression 35.25 12.20 38 38221 15537 90574651
Sleep disorder 35.05 12.20 20 38239 198010 90392178
Pain 34.92 12.20 262 37997 996079 89594109
Injury 34.83 12.20 20 38239 197329 90392859
Ill-defined disorder 33.69 12.20 18 38241 184873 90405315
Melaena 33.65 12.20 56 38203 34741 90555447
Myocardial ischaemia 33.57 12.20 35 38224 13779 90576409
Night sweats 33.04 12.20 7 38252 128759 90461429
Product coating issue 32.75 12.20 8 38251 109 90590079
Body temperature decreased 32.51 12.20 45 38214 23771 90566417
Bursitis 32.10 12.20 8 38251 131646 90458542
Pulmonary fibrosis 31.69 12.20 4 38255 107499 90482689
Wound infection 31.27 12.20 4 38255 106398 90483790
Hypersensitivity 30.96 12.20 94 38165 454583 90135605
Mycobacterium tuberculosis complex test positive 30.61 12.20 17 38242 2595 90587593
Anion gap 30.31 12.20 13 38246 1129 90589059
Pulseless electrical activity 29.93 12.20 27 38232 8905 90581283
Cerebrovascular accident 29.75 12.20 117 38142 123416 90466772
Musculoskeletal stiffness 29.37 12.20 50 38209 296482 90293706
Hypercholesterolaemia 29.15 12.20 4 38255 100888 90489300
Maternal exposure during pregnancy 28.60 12.20 69 38190 359994 90230194
Fibromyalgia 28.51 12.20 27 38232 206242 90383946
Syncope 28.27 12.20 121 38138 132542 90457646
Electrolyte imbalance 28.21 12.20 42 38217 23703 90566485
Clinically isolated syndrome 28.17 12.20 6 38253 42 90590146
Product used for unknown indication 28.11 12.20 11 38248 756 90589432
Infection 27.50 12.20 71 38188 362023 90228165
Acquired apparent mineralocorticoid excess 27.18 12.20 5 38254 14 90590174
Cardiac complication associated with device 27.08 12.20 4 38255 0 90590188
Psoriatic arthropathy 27.01 12.20 34 38225 228301 90361887
Cardiac failure acute 26.81 12.20 29 38230 11900 90578288
Rubber sensitivity 26.68 12.20 16 38243 2821 90587367
Accidental overdose 26.67 12.20 45 38214 28228 90561960
Mental status changes 26.03 12.20 58 38201 44621 90545567
Ventricular extrasystoles 25.99 12.20 30 38229 13220 90576968
Facet joint syndrome 25.97 12.20 5 38254 98384 90491804
Neonatal respiratory distress 25.67 12.20 10 38249 679 90589509
Ventricular dyssynchrony 25.19 12.20 6 38253 73 90590115
Communication disorder 24.60 12.20 16 38243 3250 90586938
Depressed level of consciousness 24.49 12.20 77 38182 72707 90517481
Gait inability 24.23 12.20 16 38243 146440 90443748
Product monitoring error 24.22 12.20 18 38241 4526 90585662
Renal impairment 23.90 12.20 98 38161 105323 90484865
Poisoning deliberate 23.79 12.20 32 38227 16454 90573734
Road traffic accident 23.56 12.20 8 38251 107618 90482570
Cluster headache 23.56 12.20 10 38249 847 90589341
Mixed liver injury 23.51 12.20 22 38237 7601 90582587
Breast pain 22.85 12.20 25 38234 10393 90579795
Therapeutic product effect incomplete 22.80 12.20 29 38230 193867 90396321
Peripheral venous disease 22.72 12.20 4 38255 83917 90506271
Death 22.17 12.20 292 37967 456259 90133929
Sinoatrial block 22.03 12.20 10 38249 995 90589193
Stomatitis 21.52 12.20 53 38206 274645 90315543
Tricuspid valve disease 21.47 12.20 7 38252 282 90589906
Productive cough 21.04 12.20 76 38183 76987 90513201
Cerebral infarction 20.80 12.20 39 38220 26557 90563631
Somnolence 20.60 12.20 155 38104 208929 90381259
Pulmonary oedema 20.27 12.20 65 38194 62015 90528173
Hyponatraemic syndrome 20.22 12.20 8 38251 566 90589622
Red blood cell sedimentation rate increased 20.17 12.20 5 38254 82590 90507598
Intentional product misuse 20.08 12.20 83 38176 89521 90500667
Autoimmune disorder 20.04 12.20 4 38255 76740 90513448
Blood pressure decreased 19.72 12.20 73 38186 74822 90515366
Pallor 19.51 12.20 44 38215 34121 90556067
C-reactive protein increased 19.45 12.20 29 38230 181360 90408828
Hypoaesthesia 19.26 12.20 68 38191 314142 90276046
Multiple organ dysfunction syndrome 19.18 12.20 68 38191 68268 90521920
Anaemia vitamin B12 deficiency 19.00 12.20 8 38251 664 90589524
Low cardiac output syndrome 18.70 12.20 7 38252 426 90589762
Hypotonia neonatal 18.68 12.20 10 38249 1420 90588768
Exposure during pregnancy 18.67 12.20 46 38213 238364 90351824
Blood phosphorus decreased 18.43 12.20 16 38243 5018 90585170
Hip fracture 18.23 12.20 42 38217 33035 90557153
Placental calcification 17.99 12.20 4 38255 35 90590153
Hyponatraemia 17.98 12.20 107 38152 133431 90456757
Cholestatic liver injury 17.95 12.20 14 38245 3783 90586405
Stress 17.93 12.20 75 38184 81320 90508868
Hip arthroplasty 17.87 12.20 5 38254 76203 90513985
Fall 17.82 12.20 294 37965 481516 90108672
Musculoskeletal pain 17.76 12.20 28 38231 171223 90418965
Intentional product use issue 17.65 12.20 41 38218 216851 90373337
Pyrexia 17.64 12.20 186 38073 660299 89929889
Weight increased 17.53 12.20 104 38155 417823 90172365
Lower limb fracture 17.46 12.20 7 38252 85006 90505182
Bundle branch block left 17.43 12.20 19 38240 7866 90582322
Sinus arrest 17.37 12.20 11 38248 2135 90588053
Prescribed overdose 17.06 12.20 10 38249 97615 90492573
Arthralgia 17.05 12.20 229 38030 778293 89811895
Ventricular fibrillation 16.91 12.20 25 38234 14019 90576169
Coma scale abnormal 16.90 12.20 16 38243 5610 90584578
Apraxia 16.84 12.20 11 38248 2251 90587937
Myalgia 16.78 12.20 129 38130 174996 90415192
Breast enlargement 16.77 12.20 10 38249 1745 90588443
Ischaemic stroke 16.71 12.20 32 38227 22134 90568054
Alkalosis 16.67 12.20 7 38252 577 90589611
Delirium 16.46 12.20 12 38247 104347 90485841
Normocytic anaemia 16.46 12.20 12 38247 2932 90587256
Hypokalaemia 16.35 12.20 103 38156 131013 90459175
Cardiotoxicity 16.27 12.20 22 38237 11367 90578821
Dizziness 16.06 12.20 343 37916 588941 90001247
Bleeding varicose vein 16.03 12.20 6 38253 365 90589823
Respiratory failure 16.01 12.20 95 38164 118323 90471865
Inflammation 15.99 12.20 32 38227 178560 90411628
Cerebral haemorrhage 15.99 12.20 41 38218 34481 90555707
Metastases to retroperitoneum 15.96 12.20 5 38254 177 90590011
Osteoarthritis 15.93 12.20 37 38222 195693 90394495
Interstitial lung disease 15.74 12.20 69 38190 76336 90513852
Exfoliative rash 15.59 12.20 12 38247 3180 90587008
Dyspnoea 15.58 12.20 484 37775 880471 89709717
Blood pressure immeasurable 15.57 12.20 9 38250 1483 90588705
Renal tubular disorder 15.54 12.20 12 38247 3195 90586993
Poisoning 15.40 12.20 25 38234 15192 90574996
Salivary gland calculus 15.32 12.20 5 38254 202 90589986
Circulatory collapse 15.27 12.20 33 38226 24871 90565317
Type III immune complex mediated reaction 15.27 12.20 6 38253 417 90589771
Interspinous osteoarthritis 15.13 12.20 4 38255 76 90590112
Hepatocellular injury 15.11 12.20 36 38223 28922 90561266
Embolic stroke 15.02 12.20 13 38246 4059 90586129
Palpitations 14.98 12.20 104 38155 136624 90453564
Stress cardiomyopathy 14.98 12.20 23 38236 13332 90576856
Product physical issue 14.95 12.20 15 38244 5645 90584543
Frequent bowel movements 14.80 12.20 3 38256 56932 90533256
Pregnancy 14.68 12.20 4 38255 62043 90528145
Urticaria 14.65 12.20 75 38184 312659 90277529
Hypertrophic cardiomyopathy 14.58 12.20 10 38249 2218 90587970
Tachycardia 14.48 12.20 115 38144 157558 90432630
Gallbladder oedema 14.46 12.20 5 38254 242 90589946
Dislocation of vertebra 14.44 12.20 3 38256 55965 90534223
Obesity 14.35 12.20 14 38245 105493 90484695
Conduction disorder 14.31 12.20 9 38250 1726 90588462
Blepharospasm 14.25 12.20 3 38256 55442 90534746
Atrial flutter 14.19 12.20 20 38239 10738 90579450
Malabsorption 14.19 12.20 14 38245 5164 90585024
Pneumonia chlamydial 14.09 12.20 4 38255 100 90590088
Dry mouth 14.03 12.20 36 38223 184023 90406165
Tachycardia induced cardiomyopathy 13.98 12.20 4 38255 103 90590085
Live birth 13.97 12.20 8 38251 79099 90511089
Chronic obstructive pulmonary disease 13.96 12.20 65 38194 73764 90516424
Hypoxia 13.88 12.20 64 38195 72335 90517853
Loss of consciousness 13.83 12.20 104 38155 140134 90450054
Nasopharyngitis 13.74 12.20 108 38151 406996 90183192
Rhabdomyosarcoma 13.70 12.20 4 38255 111 90590077
Febrile neutropenia 13.65 12.20 29 38230 158320 90431868
Blood pressure diastolic decreased 13.63 12.20 33 38226 26793 90563395
Epilepsy 13.57 12.20 9 38250 82197 90507991
Toxic skin eruption 13.43 12.20 24 38235 15750 90574438
Loss of personal independence in daily activities 13.42 12.20 23 38236 136082 90454106
Haemarthrosis 13.24 12.20 12 38247 3982 90586206
Hepatitis A antibody abnormal 13.12 12.20 4 38255 129 90590059
Malignant neoplasm of ampulla of Vater 12.87 12.20 3 38256 33 90590155
Haemorrhage subcutaneous 12.85 12.20 11 38248 3385 90586803
Periorbital oedema 12.68 12.20 15 38244 6784 90583404
Myoclonus 12.44 12.20 26 38233 19142 90571046
Ventricular arrhythmia 12.43 12.20 12 38247 4309 90585879
Anion gap abnormal 12.41 12.20 5 38254 371 90589817
Subacute cutaneous lupus erythematosus 12.34 12.20 11 38248 3571 90586617
Heart rate decreased 12.33 12.20 50 38209 53455 90536733
Confusional state 12.33 12.20 104 38155 386101 90204087
Epidermolysis 12.29 12.20 6 38253 703 90589485
Herbal interaction 12.27 12.20 4 38255 161 90590027

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 620.37 13.50 453 20517 96012 42504353
Cardiogenic shock 312.51 13.50 203 20767 35437 42564928
Bradycardia 309.59 13.50 288 20682 85196 42515169
Toxicity to various agents 184.06 13.50 370 20600 228766 42371599
Hypotension 158.89 13.50 374 20596 257257 42343108
Intentional overdose 153.39 13.50 156 20814 51300 42549065
Shock 108.80 13.50 100 20870 29021 42571344
Atrioventricular block complete 107.57 13.50 68 20902 11296 42589069
Brain scan abnormal 103.36 13.50 34 20936 1205 42599160
Cerebral artery thrombosis 103.09 13.50 34 20936 1215 42599150
Nodal rhythm 90.75 13.50 33 20937 1584 42598781
Drug interaction 82.31 13.50 303 20667 266696 42333669
Areflexia 81.94 13.50 39 20931 3704 42596661
Hemiplegia 69.24 13.50 45 20925 7834 42592531
Overdose 66.96 13.50 155 20815 105109 42495256
Vasoplegia syndrome 59.14 13.50 28 20942 2627 42597738
Coma 50.74 13.50 93 20877 53461 42546904
Febrile neutropenia 49.40 13.50 15 20955 185688 42414677
Ischaemic stroke 46.44 13.50 56 20914 22177 42578188
Acute respiratory distress syndrome 44.53 13.50 64 20906 30044 42570321
BRASH syndrome 42.98 13.50 20 20950 1805 42598560
Compartment syndrome 42.35 13.50 24 20946 3265 42597100
Facial paralysis 39.05 13.50 39 20931 12524 42587841
Cardiac arrest 37.77 13.50 129 20841 109191 42491174
Nodular melanoma 36.46 13.50 10 20960 187 42600178
Pacemaker generated rhythm 35.62 13.50 8 20962 62 42600303
Coma scale abnormal 35.11 13.50 24 20946 4541 42595824
Oesophageal ulcer haemorrhage 33.93 13.50 11 20959 372 42599993
Sinus bradycardia 33.64 13.50 39 20931 14814 42585551
Hyperkalaemia 33.28 13.50 101 20869 80357 42520008
Antiacetylcholine receptor antibody positive 32.62 13.50 8 20962 94 42600271
Prostatic adenoma 32.11 13.50 9 20961 183 42600182
Pseudomonal sepsis 31.88 13.50 22 20948 4227 42596138
Bundle branch block left 31.78 13.50 26 20944 6450 42593915
Cerebral haematoma 30.68 13.50 24 20946 5586 42594779
Respiratory distress 30.39 13.50 65 20905 41755 42558610
Pulse absent 30.21 13.50 25 20945 6302 42594063
Atrioventricular block first degree 29.65 13.50 25 20945 6466 42593899
Suicide attempt 29.39 13.50 68 20902 46032 42554333
Supraventricular tachycardia 28.81 13.50 33 20937 12375 42587990
Lactic acidosis 28.02 13.50 66 20904 45195 42555170
Cerebral infarction 26.86 13.50 52 20918 31117 42569248
Lip discolouration 26.79 13.50 8 20962 205 42600160
Rhythm idioventricular 26.71 13.50 9 20961 344 42600021
Electrocardiogram QT prolonged 26.58 13.50 67 20903 47878 42552487
Embolic stroke 26.35 13.50 21 20949 5019 42595346
Neuromyopathy 25.38 13.50 12 20958 1122 42599243
Poisoning deliberate 25.32 13.50 28 20942 10106 42590259
Nodal arrhythmia 24.80 13.50 11 20959 888 42599477
Disease progression 24.25 13.50 21 20949 143635 42456730
Superinfection 23.85 13.50 16 20954 2935 42597430
Left ventricle outflow tract obstruction 23.60 13.50 7 20963 175 42600190
Pyrexia 23.46 13.50 107 20863 393935 42206430
Xanthelasma 23.18 13.50 6 20964 89 42600276
Cluster headache 22.62 13.50 9 20961 553 42599812
Mallory-Weiss syndrome 22.05 13.50 12 20958 1509 42598856
Cardiorenal syndrome 21.69 13.50 10 20960 883 42599482
Haemodynamic instability 20.50 13.50 28 20942 12529 42587836
Hepatocellular injury 19.79 13.50 39 20931 23639 42576726
Therapeutic drug monitoring analysis incorrectly performed 19.62 13.50 7 20963 318 42600047
Foetal growth restriction 19.44 13.50 18 20952 5265 42595100
Victim of crime 19.44 13.50 8 20962 537 42599828
Alkalosis hypochloraemic 19.41 13.50 7 20963 328 42600037
Antineutrophil cytoplasmic antibody increased 18.99 13.50 4 20966 22 42600343
Suspected suicide 18.81 13.50 19 20951 6180 42594185
Labelled drug-drug interaction medication error 18.61 13.50 30 20940 15552 42584813
Tobacco abuse 18.44 13.50 8 20962 612 42599753
Atrial fibrillation 18.02 13.50 124 20846 139469 42460896
Dyspnoea 17.80 13.50 311 20659 442310 42158055
Acute kidney injury 17.71 13.50 266 20704 367071 42233294
Palpitations 17.57 13.50 60 20910 50737 42549628
Neutrophil count decreased 17.06 13.50 5 20965 63410 42536955
Disease recurrence 16.99 13.50 42 20928 29636 42570729
Defect conduction intraventricular 16.95 13.50 7 20963 474 42599891
Pallor 16.67 13.50 41 20929 28845 42571520
Lymphoedema 16.57 13.50 16 20954 4932 42595433
Atrioventricular block 16.55 13.50 22 20948 9593 42590772
Tachycardia 16.26 13.50 95 20875 100992 42499373
Atrioventricular dissociation 16.12 13.50 5 20965 146 42600219
Hyperthermia 16.11 13.50 25 20945 12549 42587816
Arrhythmia 16.08 13.50 50 20920 40267 42560098
Normochromic normocytic anaemia 16.07 13.50 21 20949 9010 42591355
Sudden death 15.89 13.50 29 20941 16600 42583765
Cardio-respiratory arrest 15.87 13.50 64 20906 58572 42541793
Neutropenia 15.86 13.50 48 20922 199383 42400982
Disturbance in attention 15.78 13.50 41 20929 29825 42570540
Pancytopenia 15.65 13.50 21 20949 117722 42482643
Prothrombin time ratio decreased 15.58 13.50 7 20963 582 42599783
Erythromelalgia 15.47 13.50 4 20966 59 42600306
Pain 15.44 13.50 65 20905 244783 42355582
Heart rate abnormal 15.42 13.50 11 20959 2228 42598137
Diarrhoea 15.33 13.50 149 20821 460700 42139665
Neck injury 15.24 13.50 9 20961 1322 42599043
Hyperparathyroidism primary 15.23 13.50 5 20965 176 42600189
Myofascial pain syndrome 15.20 13.50 6 20964 361 42600004
Acidosis 15.16 13.50 24 20946 12255 42588110
COVID-19 15.09 13.50 21 20949 115927 42484438
Mucosal inflammation 15.03 13.50 3 20967 49371 42550994
Drug diversion 14.90 13.50 8 20962 979 42599386
Anuria 14.87 13.50 23 20947 11509 42588856
Wrong patient received product 14.74 13.50 13 20957 3570 42596795
Hypoparathyroidism secondary 14.64 13.50 5 20965 199 42600166
Unresponsive to stimuli 14.48 13.50 41 20929 31362 42569003
Hypertrophic cardiomyopathy 14.44 13.50 9 20961 1456 42598909
Anaphylactic reaction 14.35 13.50 50 20920 42693 42557672
Gravitational oedema 14.35 13.50 7 20963 701 42599664
Sinus rhythm 14.30 13.50 6 20964 423 42599942
Altered state of consciousness 14.28 13.50 39 20931 29220 42571145
Ileus 14.19 13.50 30 20940 19109 42581256
Hyperlactacidaemia 14.00 13.50 14 20956 4502 42595863
Nervous system disorder 13.98 13.50 28 20942 17167 42583198
Thalamus haemorrhage 13.96 13.50 8 20962 1111 42599254
Rebound tachycardia 13.89 13.50 3 20967 19 42600346
Vascular resistance systemic decreased 13.72 13.50 4 20966 94 42600271
Haemoglobin decreased 13.55 13.50 28 20942 132443 42467922

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1812.16 11.78 1240 52332 241141 110294586
Bradycardia 899.28 11.78 682 52890 154835 110380892
Cardiogenic shock 704.03 11.78 403 53169 56935 110478792
Toxicity to various agents 642.19 11.78 963 52609 479592 110056135
Hypotension 535.94 11.78 930 52642 522919 110012808
Atrioventricular block complete 451.40 11.78 212 53360 19870 110515857
Drug interaction 426.36 11.78 821 52751 499362 110036365
BRASH syndrome 381.47 11.78 119 53453 3604 110532123
Intentional overdose 312.01 11.78 352 53220 132149 110403578
Overdose 253.87 11.78 427 53145 233367 110302360
Shock 218.40 11.78 192 53380 53396 110482331
Atrioventricular block 216.05 11.78 122 53450 16755 110518972
Nodal rhythm 164.22 11.78 62 53510 3361 110532366
Anuria 158.81 11.78 115 53457 24226 110511501
Metabolic acidosis 156.03 11.78 216 53356 99528 110436199
Neovascularisation 155.10 11.78 50 53522 1687 110534040
Vasoplegia syndrome 152.48 11.78 67 53505 5372 110530355
Acute respiratory distress syndrome 147.23 11.78 154 53418 53044 110482683
Cardiac arrest 143.16 11.78 303 53269 196450 110339277
Atrioventricular block first degree 133.00 11.78 84 53488 14141 110521586
Sinus bradycardia 130.98 11.78 111 53461 29372 110506355
Electrocardiogram QT prolonged 123.44 11.78 203 53369 108757 110426970
Coma 120.81 11.78 210 53362 117659 110418068
Synovitis 114.92 11.78 4 53568 274088 110261639
Joint swelling 105.96 11.78 41 53531 442804 110092923
Electrocardiogram QRS complex prolonged 104.82 11.78 70 53502 12951 110522776
Drug ineffective for unapproved indication 101.20 11.78 180 53392 102658 110433069
Infusion related reaction 96.78 11.78 32 53540 381130 110154597
Brain scan abnormal 92.17 11.78 33 53539 1538 110534189
Systemic lupus erythematosus 90.78 11.78 9 53563 254329 110281398
Rhythm idioventricular 88.48 11.78 27 53545 758 110534969
Distributive shock 87.45 11.78 47 53525 5857 110529870
Glossodynia 87.30 11.78 5 53567 221999 110313728
Pemphigus 87.01 11.78 4 53568 214566 110321161
Cerebral artery thrombosis 86.54 11.78 32 53540 1636 110534091
Cryopyrin associated periodic syndrome 85.65 11.78 25 53547 600 110535127
Arthropathy 84.59 11.78 18 53554 287504 110248223
Hepatic enzyme increased 81.34 11.78 27 53545 320865 110214862
Pericarditis 77.55 11.78 8 53564 219106 110316621
Paradoxical drug reaction 74.77 11.78 51 53521 9766 110525961
Labelled drug-drug interaction medication error 74.31 11.78 81 53491 29221 110506506
Duodenal ulcer perforation 73.08 11.78 3 53569 177697 110358030
Atrial fibrillation 72.18 11.78 260 53312 229382 110306345
Nodal arrhythmia 71.41 11.78 30 53542 2154 110533573
Hyperglycaemia 70.06 11.78 138 53434 84952 110450775
Hyperkalaemia 67.09 11.78 180 53392 135616 110400111
Swelling 66.72 11.78 44 53528 350997 110184730
Lower respiratory tract infection 66.05 11.78 18 53554 243088 110292639
Cardio-respiratory arrest 64.92 11.78 161 53411 115675 110420052
Suicide attempt 64.71 11.78 150 53422 103244 110432483
Wound 62.50 11.78 18 53554 234419 110301308
Folliculitis 62.33 11.78 5 53567 167648 110368079
Acute kidney injury 61.95 11.78 522 53050 634908 109900819
Areflexia 60.86 11.78 39 53533 6730 110528997
Lactic acidosis 60.69 11.78 137 53435 92674 110443053
Supraventricular tachycardia 59.31 11.78 66 53506 24356 110511371
Febrile neutropenia 58.46 11.78 41 53531 316726 110219001
Irritable bowel syndrome 58.09 11.78 6 53566 164209 110371518
Ischaemic stroke 58.06 11.78 85 53487 41178 110494549
Therapeutic product effect decreased 56.14 11.78 24 53548 244292 110291435
Fear of disease 55.31 11.78 22 53550 1373 110534354
Atrioventricular dissociation 55.05 11.78 16 53556 378 110535349
Rheumatoid arthritis 53.69 11.78 40 53532 299573 110236154
Suspected suicide 51.25 11.78 49 53523 15150 110520577
Non-cardiogenic pulmonary oedema 51.00 11.78 23 53549 1961 110533766
Impaired healing 50.80 11.78 16 53556 196701 110339026
Type 2 diabetes mellitus 50.29 11.78 12 53560 177220 110358507
Coma scale abnormal 50.28 11.78 40 53532 9686 110526041
Cerebral infarction 50.03 11.78 90 53482 51748 110483979
Blood cholesterol increased 49.59 11.78 14 53558 184771 110350956
Sinus node dysfunction 48.47 11.78 38 53534 9009 110526718
Pain 48.12 11.78 269 53303 954686 109581041
Alopecia 47.82 11.78 64 53508 364689 110171038
Atrioventricular block second degree 47.41 11.78 36 53536 8145 110527582
Cardiac failure 46.39 11.78 197 53375 187429 110348298
Poisoning deliberate 45.68 11.78 60 53512 26271 110509456
Musculoskeletal stiffness 45.61 11.78 41 53531 279781 110255946
Liver injury 45.08 11.78 9 53563 150404 110385323
Hypoglobulinaemia 44.32 11.78 12 53560 217 110535510
Rhabdomyolysis 42.74 11.78 142 53430 120259 110415468
Bundle branch block left 42.42 11.78 41 53531 12847 110522880
Mobility decreased 42.14 11.78 32 53540 237390 110298337
Embolic stroke 41.06 11.78 34 53538 8709 110527018
Cardiac failure congestive 40.03 11.78 162 53410 150838 110384889
Extrapyramidal disorder 39.94 11.78 59 53513 28808 110506919
Medication overuse headache 39.79 11.78 18 53554 1545 110534182
Fibromyalgia 38.92 11.78 17 53555 170892 110364835
Gastrointestinal disorder 38.77 11.78 36 53536 241916 110293811
Bursitis 38.46 11.78 8 53564 129910 110405817
Bundle branch block right 38.40 11.78 38 53534 12253 110523474
Arrhythmia 38.23 11.78 96 53476 69479 110466248
Discomfort 38.02 11.78 29 53543 214678 110321049
Cluster headache 37.54 11.78 16 53556 1191 110534536
Pulseless electrical activity 36.82 11.78 43 53529 16714 110519013
Compartment syndrome 36.46 11.78 27 53545 5883 110529844
Cerebrovascular accident 36.37 11.78 179 53393 181105 110354622
Facial paralysis 35.70 11.78 51 53521 24163 110511564
Acute lung injury 35.58 11.78 21 53551 3130 110532597
Prostatic adenoma 35.52 11.78 9 53563 124 110535603
Pacemaker generated rhythm 35.30 11.78 8 53564 66 110535661
Myocardial stunning 35.19 11.78 11 53561 335 110535392
Infection 35.13 11.78 77 53495 362123 110173604
Syncope 35.10 11.78 192 53380 202344 110333383
Sinoatrial block 34.56 11.78 16 53556 1449 110534278
Hepatocellular injury 34.49 11.78 76 53496 50566 110485161
Product monitoring error 34.39 11.78 31 53541 8896 110526831
Altered state of consciousness 34.30 11.78 82 53490 57544 110478183
Hemiplegia 33.61 11.78 48 53524 22734 110512993
Pulse absent 33.60 11.78 34 53538 11258 110524469
Hypertrophic cardiomyopathy 32.92 11.78 20 53552 3143 110532584
Nodular melanoma 32.90 11.78 10 53562 277 110535450
Injury 32.61 11.78 23 53549 177242 110358485
Amaurosis fugax 32.55 11.78 18 53554 2372 110533355
Tongue oedema 32.46 11.78 29 53543 8227 110527500
Tachycardia 32.26 11.78 204 53368 226441 110309286
Haemodynamic instability 31.98 11.78 47 53525 22841 110512886
Pyrexia 31.92 11.78 280 53292 897985 109637742
Disease progression 31.78 11.78 43 53529 243991 110291736
Abdominal discomfort 31.78 11.78 92 53480 393766 110141961
Night sweats 31.03 11.78 13 53559 133970 110401757
Road traffic accident 31.00 11.78 7 53565 107391 110428336
Product coating issue 30.94 11.78 8 53564 120 110535607
Rash 30.92 11.78 252 53320 820712 109715015
Facet joint syndrome 30.73 11.78 5 53567 96823 110438904
Ill-defined disorder 30.68 11.78 19 53553 156834 110378893
Dry mouth 30.58 11.78 31 53541 199917 110335810
Hypercholesterolaemia 30.43 11.78 4 53568 90833 110444894
Weight increased 30.35 11.78 103 53469 419541 110116186
Left ventricle outflow tract obstruction 30.33 11.78 11 53561 532 110535195
Large intestine polyp 30.27 11.78 37 53535 15080 110520647
Pallor 30.07 11.78 77 53495 56390 110479337
Hypersensitivity 30.01 11.78 98 53474 403900 110131827
Peripheral venous disease 29.94 11.78 3 53569 84114 110451613
Reversible cerebral vasoconstriction syndrome 29.93 11.78 22 53550 4739 110530988
Myelosuppression 29.65 11.78 5 53567 94335 110441392
Sleep disorder 29.04 11.78 32 53540 198612 110337115
Blister 28.67 11.78 41 53531 227335 110308392
Myocardial ischaemia 27.91 11.78 48 53524 26636 110509091
Respiratory failure 27.71 11.78 189 53383 215143 110320584
Oesophageal ulcer haemorrhage 27.57 11.78 12 53560 940 110534787
Cough 27.48 11.78 343 53229 461298 110074429
Rubber sensitivity 27.01 11.78 16 53556 2402 110533325
Acidosis 26.88 11.78 43 53529 22488 110513239
Drug intolerance 26.61 11.78 104 53468 406408 110129319
Cardiac complication associated with device 26.53 11.78 4 53568 0 110535727
Clinically isolated syndrome 26.53 11.78 6 53566 49 110535678
Wound infection 26.46 11.78 7 53565 96458 110439269
Intentional product use issue 26.33 11.78 50 53522 247856 110287871
Psoriatic arthropathy 26.30 11.78 34 53538 196727 110339000
Low cardiac output syndrome 25.84 11.78 12 53560 1094 110534633
Mycobacterium tuberculosis complex test positive 24.85 11.78 17 53555 3271 110532456
Antiacetylcholine receptor antibody positive 24.75 11.78 8 53564 272 110535455
Contraindicated product administered 24.71 11.78 52 53520 248215 110287512
Device pacing issue 24.35 11.78 7 53565 159 110535568
Pulmonary oedema 24.33 11.78 105 53467 100554 110435173
Dyspnoea 23.87 11.78 703 52869 1106169 109429558
Gait inability 23.41 11.78 19 53553 136357 110399370
Mixed liver injury 23.27 11.78 29 53543 12050 110523677
Obesity 23.20 11.78 13 53559 113338 110422389
Neuromyopathy 23.14 11.78 13 53559 1766 110533961
Sinus arrest 23.12 11.78 18 53554 4224 110531503
Ventricular dyssynchrony 23.08 11.78 6 53566 92 110535635
Osteoarthritis 22.95 11.78 33 53539 182590 110353137
Stomatitis 22.62 11.78 62 53510 270180 110265547
Breast pain 22.54 11.78 26 53546 9974 110525753
Poisoning 22.51 11.78 46 53526 29059 110506668
Maternal exposure during pregnancy 22.45 11.78 57 53515 254826 110280901
C-reactive protein increased 22.23 11.78 45 53527 217874 110317853
Periorbital oedema 22.14 11.78 26 53546 10166 110525561
Hypoaesthesia 22.12 11.78 78 53494 314145 110221582
Frequent bowel movements 21.96 11.78 4 53568 71386 110464341
Urticaria 21.88 11.78 80 53492 318777 110216950
Blood pressure immeasurable 21.88 11.78 14 53558 2409 110533318
Neutrophil count decreased 21.84 11.78 16 53556 120925 110414802
Anion gap 21.82 11.78 13 53559 1972 110533755
Cerebral haematoma 21.63 11.78 25 53547 9607 110526120
Therapeutic product effect incomplete 21.34 11.78 48 53524 223757 110311970
Melaena 20.85 11.78 77 53495 68680 110467047
Internal haemorrhage 20.73 11.78 25 53547 10046 110525681
Malignant neoplasm progression 20.54 11.78 33 53539 174534 110361193
Body temperature decreased 20.32 11.78 51 53521 36884 110498843
Musculoskeletal pain 20.24 11.78 36 53536 182987 110352740
Pancytopenia 19.95 11.78 45 53527 209568 110326159
Acute myocardial infarction 19.95 11.78 87 53485 83690 110452037
Haematoma 19.89 11.78 68 53504 58408 110477319
Xanthelasma 19.85 11.78 6 53566 163 110535564
Pseudomonal sepsis 19.52 11.78 23 53549 9023 110526704
Arthralgia 19.26 11.78 264 53308 779368 109756359
Electrolyte imbalance 19.20 11.78 50 53522 36978 110498749
Respiratory distress 19.13 11.78 75 53497 68799 110466928
Electrocardiogram T wave abnormal 18.98 11.78 16 53556 4201 110531526
Loss of consciousness 18.91 11.78 161 53411 196145 110339582
Alkalosis hypochloraemic 18.80 11.78 8 53564 593 110535134
Placental calcification 18.76 11.78 4 53568 24 110535703
Cardiac failure acute 18.55 11.78 38 53534 24040 110511687
Communication disorder 18.44 11.78 17 53555 5022 110530705
Head discomfort 18.35 11.78 33 53539 18967 110516760
Sciatica 18.33 11.78 11 53561 92388 110443339
Palpitations 18.30 11.78 136 53436 159076 110376651
Choking sensation 18.27 11.78 16 53556 4420 110531307
Cerebral haemorrhage 18.25 11.78 71 53501 64897 110470830
Urinary tract disorder 18.13 11.78 18 53554 5826 110529901
Acquired apparent mineralocorticoid excess 17.99 11.78 5 53567 100 110535627
Tachycardia induced cardiomyopathy 17.98 11.78 6 53566 226 110535501
Lower limb fracture 17.95 11.78 7 53565 75341 110460386
Ventricular extrasystoles 17.76 11.78 36 53536 22605 110513122
Myalgia 17.68 11.78 175 53397 222206 110313521
Autoimmune disorder 17.49 11.78 5 53567 65478 110470249
Red blood cell sedimentation rate increased 17.49 11.78 8 53564 78294 110457433
Sinusitis 17.49 11.78 79 53493 296609 110239118
Conduction disorder 17.46 11.78 15 53557 4040 110531687
Blood pressure decreased 17.24 11.78 105 53467 114986 110420741
Inflammation 17.18 11.78 43 53529 193195 110342532
Cardiotoxicity 17.18 11.78 30 53542 16851 110518876
Tricuspid valve disease 17.09 11.78 7 53565 471 110535256
Loss of personal independence in daily activities 17.05 11.78 29 53543 149991 110385736
Product used for unknown indication 16.88 11.78 11 53561 1952 110533775
Presyncope 16.76 11.78 57 53515 48830 110486897
Hyponatraemic syndrome 16.64 11.78 8 53564 789 110534938
Generalised oedema 16.48 11.78 42 53530 30662 110505065
Mallory-Weiss syndrome 16.34 11.78 13 53559 3148 110532579
Nail disorder 16.28 11.78 4 53568 57931 110477796
Nasopharyngitis 16.24 11.78 118 53454 394243 110141484
Anaemia vitamin B12 deficiency 16.05 11.78 9 53563 1218 110534509
Disturbance in attention 16.01 11.78 66 53506 61929 110473798
Multiple organ dysfunction syndrome 15.99 11.78 127 53445 151583 110384144
Renal failure 15.97 11.78 174 53398 226400 110309327
Exfoliative rash 15.90 11.78 15 53557 4559 110531168
Renal impairment 15.81 11.78 150 53422 188295 110347432
Hip fracture 15.77 11.78 45 53527 35106 110500621
Peripheral swelling 15.64 11.78 123 53449 403911 110131816
Gallbladder oedema 15.29 11.78 6 53566 361 110535366
Fall 15.13 11.78 391 53181 603091 109932636
Drug diversion 15.07 11.78 9 53563 1371 110534356
Victim of crime 15.05 11.78 9 53563 1374 110534353
Superinfection 14.73 11.78 16 53556 5747 110529980
Hypokalaemia 14.70 11.78 144 53428 182304 110353423
Cardiorenal syndrome 14.69 11.78 10 53562 1908 110533819
Circulatory collapse 14.62 11.78 50 53522 42943 110492784
Interspinous osteoarthritis 14.59 11.78 4 53568 76 110535651
Hyperthermia 14.57 11.78 32 53540 21240 110514487
Hyperlactacidaemia 14.56 11.78 19 53553 8267 110527460
Medication error 14.46 11.78 94 53478 105272 110430455
Wrong patient received product 14.45 11.78 17 53555 6657 110529070
Tobacco abuse 14.44 11.78 8 53564 1058 110534669
Therapeutic drug monitoring analysis incorrectly performed 14.42 11.78 7 53565 705 110535022
Intentional product misuse 14.41 11.78 112 53460 132792 110402935
Wrong patient 14.38 11.78 9 53563 1490 110534237
Product prescribing error 14.34 11.78 56 53516 51275 110484452
Defect conduction intraventricular 14.33 11.78 7 53565 714 110535013
Live birth 14.17 11.78 8 53564 69476 110466251
Depressed level of consciousness 14.11 11.78 98 53474 112180 110423547
Pneumonia aspiration 14.05 11.78 77 53495 81156 110454571
Atrial flutter 13.87 11.78 34 53538 24228 110511499
Contusion 13.83 11.78 62 53510 233299 110302428
Tobacco user 13.83 11.78 7 53565 771 110534956
Mental status changes 13.74 11.78 73 53499 76049 110459678
Hip arthroplasty 13.60 11.78 5 53567 55808 110479919
Alkalosis 13.60 11.78 7 53565 799 110534928
Haemorrhage subcutaneous 13.50 11.78 15 53557 5524 110530203
Hyponatraemia 13.48 11.78 163 53409 217490 110318237
Pregnancy 13.45 11.78 4 53568 51063 110484664
Haemorrhagic stroke 13.38 11.78 24 53548 13765 110521962
Accidental overdose 13.24 11.78 55 53517 51779 110483948
Platelet count decreased 13.19 11.78 62 53510 230381 110305346
Neutropenia 13.16 11.78 117 53455 374503 110161224
Ventricular fibrillation 13.15 11.78 47 53525 41266 110494461
Cytokine release syndrome 13.09 11.78 9 53563 70297 110465430
Tachyarrhythmia 13.07 11.78 18 53554 8243 110527484
Hypoparathyroidism secondary 13.02 11.78 5 53567 284 110535443
Colitis ulcerative 13.00 11.78 11 53561 77352 110458375
Muscular weakness 13.00 11.78 69 53503 248399 110287328
Delirium 12.83 11.78 29 53543 134996 110400731
Chronotropic incompetence 12.76 11.78 4 53568 123 110535604
Nervous system disorder 12.70 11.78 39 53533 31682 110504045
Taste disorder 12.67 11.78 8 53564 65379 110470348
Ocular discomfort 12.62 11.78 18 53554 8515 110527212
Hepatitis A antibody abnormal 12.58 11.78 4 53568 129 110535598
Respiratory depression 12.49 11.78 39 53533 31962 110503765
Mucosal inflammation 12.45 11.78 17 53555 96124 110439603
Dislocation of vertebra 12.32 11.78 3 53569 43718 110492009
Pneumonia chlamydial 12.29 11.78 4 53568 139 110535588
Thalamus haemorrhage 12.18 11.78 9 53563 1955 110533772
Malignant neoplasm of ampulla of Vater 12.07 11.78 3 53569 38 110535689
Respiratory arrest 11.99 11.78 58 53514 58241 110477486
Vestibular disorder 11.87 11.78 10 53562 2622 110533105
Heart rate abnormal 11.80 11.78 16 53556 7222 110528505

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal growth restriction 20.04 10.92 5 3 716 113229

Pharmacologic Action:

SourceCodeDescription
ATC C08DA01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
Phenylalkylamine derivatives
ATC C08DA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
Phenylalkylamine derivatives
ATC C09BB10 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175566 Calcium Channel Blocker
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
MeSH PA D049990 Membrane Transport Modulators
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors
FDA MoA N0000190114 Cytochrome P450 3A Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:38215 calcium channel blocker
CHEBI has role CHEBI:62872 EC 1.2.3.1 (aldehyde oxidase) inhibitor
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:77255 EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor
CHEBI has role CHEBI:77745 EC 3.4.24.18 (meprin A) inhibitor
CHEBI has role CHEBI:77747 EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor
CHEBI has role CHEBI:77748 EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

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C09BB ACE inhibitors and calcium channel blockers 13 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Atrial fibrillation indication 49436004 DOID:0060224
Paroxysmal supraventricular tachycardia indication 67198005
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Acute coronary syndrome indication 394659003
Prevention of Paroxysmal Supraventricular Tachycardia indication
Cardioversion of Atrial Fibrillation indication
Diastolic heart failure off-label use 418304008 DOID:9775
Cluster Headache Prevention off-label use
Hyperkalemia contraindication 14140009
Ventricular tachycardia contraindication 25569003
Complete atrioventricular block contraindication 27885002
Acute cerebrovascular insufficiency contraindication 29322000
Sick sinus syndrome contraindication 36083008 DOID:13884
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Low cardiac output syndrome contraindication 44088000
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Lown-Ganong-Levine syndrome contraindication 55475008 DOID:13087
Aortic valve stenosis contraindication 60573004 DOID:1712
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Left heart failure contraindication 85232009
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of connective tissue contraindication 105969002 DOID:65
Liver function tests abnormal contraindication 166603001
Second degree atrioventricular block contraindication 195042002
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
First Degree Atrioventricular Heart Block contraindication
Neuromuscular Transmission Deficiency contraindication
Hemodialysis with High-Flux Membrane contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.91 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER IC50 6 WOMBAT-PK CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel BLOCKER UNKNOWN IUPHAR
Alpha-2A adrenergic receptor GPCR Ki 6.66 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 8 CHEMBL
Cytochrome P450 3A4 Enzyme INHIBITOR Ki 6.22 IUPHAR
Multidrug resistance protein 1 Transporter Ki 6.52 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.90 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 5.76 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.85 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 6.98 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.81 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 7.20 DRUG MATRIX
Histamine H2 receptor GPCR Ki 5.59 DRUG MATRIX
Aldehyde oxidase Enzyme IC50 5.46 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 6.07 DRUG MATRIX
Multidrug resistance-associated protein 1 Transporter Ki 4.88 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter EC50 4.43 CHEMBL
Carbonic anhydrase 1 Enzyme WOMBAT-PK
G protein-activated inward rectifier potassium channel 2 Ion channel WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel BLOCKER Ki 4.49 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 10 Ion channel BLOCKER IC50 4.30 IUPHAR
Potassium voltage-gated channel subfamily A member 3 Ion channel IC50 5.10 CHEMBL
Potassium voltage-gated channel subfamily C member 2 Ion channel EC50 4.90 WOMBAT-PK
Solute carrier family 22 member 1 Transporter IC50 5.17 CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 4.35 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 7 Ion channel Kd 4.80 WOMBAT-PK
Solute carrier family 22 member 2 Transporter IC50 4.07 WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.48 CHEMBL
Two pore calcium channel protein 1 Ion channel BLOCKER IC50 4.64 IUPHAR
Equilibrative nucleoside transporter 4 Transporter INHIBITOR Ki 4.73 IUPHAR
Two pore calcium channel protein 2 Ion channel BLOCKER IC50 5 IUPHAR
Sodium channel protein type 5 subunit alpha Ion channel WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 6.03 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 5.76 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 5.68 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.52 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 6 CHEMBL
Translocator protein Membrane receptor IC50 8.85 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel IC50 7.41 CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1S Ion channel Ki 7.24 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR EC50 4.51 CHEMBL
Voltage-gated L-type calcium channel Ion channel IC50 8.43 CHEMBL
Chloroquine resistance transporter Transporter IC50 4.52 CHEMBL
Potassium voltage-gated channel subfamily C member 2 Ion channel BLOCKER EC50 4.90 IUPHAR

External reference:

IDSource
4019969 VUID
N0000148054 NUI
D00619 KEGG_DRUG
152-11-4 SECONDARY_CAS_RN
4018128 VANDF
4019969 VANDF
C0042523 UMLSCUI
CHEBI:9948 CHEBI
CHEMBL6966 ChEMBL_ID
CHEMBL1280 ChEMBL_ID
D014700 MESH_DESCRIPTOR_UI
DB00661 DRUGBANK_ID
2406 IUPHAR_LIGAND_ID
2122 INN_ID
CJ0O37KU29 UNII
2520 PUBCHEM_CID
11170 RXNORM
5670 MMSL
757 MMSL
d00048 MMSL
000709 NDDF
004515 NDDF
14340003 SNOMEDCT_US
372754009 SNOMEDCT_US
47898004 SNOMEDCT_US
CJ0O37KU29 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6320 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 16 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6380 CAPSULE, EXTENDED RELEASE 180 mg ORAL ANDA 16 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-6440 CAPSULE, EXTENDED RELEASE 240 mg ORAL ANDA 16 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9966 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9966 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
VERAPAMIL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9967 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
VERAPAMIL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9967 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 11 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9968 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 12 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9968 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 12 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1144 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 21 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1144 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 21 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-4011 INJECTION, SOLUTION 2.50 mg INTRAVENOUS ANDA 17 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-0343 TABLET, FILM COATED 80 mg ORAL ANDA 20 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-0345 TABLET, FILM COATED 120 mg ORAL ANDA 20 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0591-0404 TABLET, FILM COATED 40 mg ORAL ANDA 20 sections
Verapamil Hydrochloride Human Prescription Drug Label 1 0591-2880 CAPSULE, DELAYED RELEASE PELLETS 120 mg ORAL NDA 25 sections
Verapamil Hydrochloride Human Prescription Drug Label 1 0591-2882 CAPSULE, DELAYED RELEASE PELLETS 180 mg ORAL NDA 25 sections
Verapamil Hydrochloride Human Prescription Drug Label 1 0591-2884 CAPSULE, DELAYED RELEASE PELLETS 240 mg ORAL NDA 25 sections
Verapamil Hydrochloride Human Prescription Drug Label 1 0591-2886 CAPSULE, DELAYED RELEASE PELLETS 360 mg ORAL NDA 25 sections
verapamil hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-035 TABLET, FILM COATED, EXTENDED RELEASE 240 mg ORAL ANDA 21 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-541 TABLET, FILM COATED, EXTENDED RELEASE 240 mg ORAL ANDA 23 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-570 TABLET, FILM COATED 120 mg ORAL ANDA 20 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-511 TABLET 80 mg ORAL ANDA 12 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-512 TABLET 120 mg ORAL ANDA 12 sections
Verapamil Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-868 TABLET, FILM COATED, EXTENDED RELEASE 240 mg ORAL ANDA 23 sections
VERAPAMIL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 23155-026 TABLET 80 mg ORAL ANDA 13 sections
VERAPAMIL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 23155-059 TABLET 40 mg ORAL ANDA 13 sections
VERAPAMIL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 23155-486 TABLET 120 mg ORAL ANDA 13 sections
Verapamil hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 23155-911 INJECTION 2.50 mg INTRAVENOUS ANDA 12 sections
Verapamil hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 23155-912 INJECTION 2.50 mg INTRAVENOUS ANDA 12 sections