Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
calcium channel blockers, verapamil derivatives	2815	52-53-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: verapamil RS-Verapamil (+/-)-Verapamil verapamil hydrochloride verapamil HCl	A calcium channel blocker that is a class IV anti-arrhythmia agent. Molecular weight: 454.61 Formula: C27H38N2O4 CLOGP: 4.27 LIPINSKI: 0 HAC: 6 HDO: 0 TPSA: 63.95 ALOGS: -5.06 ROTB: 13 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

verapamil
RS-Verapamil
(+/-)-Verapamil
verapamil hydrochloride
verapamil HCl

A calcium channel blocker that is a class IV anti-arrhythmia agent.

Molecular weight: 454.61
Formula: C27H38N2O4
CLOGP: 4.27
LIPINSKI: 0
HAC: 6
HDO: 0
TPSA: 63.95
ALOGS: -5.06
ROTB: 13

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.24	g	O
0.24	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ
S (Water solubility)	0.75 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1.50 %	Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability)	22 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	3.70 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	18 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.09 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	2.80 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70	50
kinase-selectivity-class	AKT3,AXL,BRAF,EIF2AK3,EPHB4,ERBB2,GRK2,PDK4,PIK3CD,PRKDC,SIK2,TEK,TTK	13
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	1.396		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	1		High	1
rat-kpuu-brain	Rat brain Kpuu	0.196	%	High	1

Approvals:

Date	Agency	Company	Orphan
Aug. 12, 1981	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1219.25	12.20	759	37500	144299	90445889
Bradycardia	681.23	12.20	430	37829	83417	90506771
Toxicity to various agents	490.73	12.20	605	37654	287241	90302947
Cardiogenic shock	421.37	12.20	206	38053	24262	90565926
Hypotension	409.97	12.20	590	37669	324807	90265381
Drug interaction	409.39	12.20	542	37717	275911	90314277
Atrioventricular block complete	385.68	12.20	148	38111	9663	90580525
BRASH syndrome	384.60	12.20	100	38159	1779	90588409
Atrioventricular block	242.88	12.20	103	38156	8712	90581476
Metabolic acidosis	202.15	12.20	176	38083	55500	90534688
Overdose	189.37	12.20	280	37979	157429	90432759
Intentional overdose	175.27	12.20	207	38052	93627	90496561
Anuria	167.08	12.20	94	38165	14724	90575464
Neovascularisation	165.01	12.20	50	38209	1580	90588608
Drug ineffective for unapproved indication	126.04	12.20	148	38111	66496	90523692
Synovitis	121.25	12.20	4	38255	329748	90260440
Electrocardiogram QRS complex prolonged	120.88	12.20	60	38199	7288	90582900
Acute respiratory distress syndrome	119.12	12.20	98	38161	28588	90561600
Glossodynia	117.97	12.20	4	38255	321775	90268413
Shock	114.69	12.20	96	38163	28682	90561506
Sinus bradycardia	113.16	12.20	77	38182	16875	90573313
Paradoxical drug reaction	112.75	12.20	53	38206	5713	90584475
Atrioventricular block first degree	112.56	12.20	60	38199	8451	90581737
Systemic lupus erythematosus	110.51	12.20	12	38247	361884	90228304
Infusion related reaction	104.44	12.20	24	38235	416756	90173432
Joint swelling	104.40	12.20	41	38218	503259	90086929
Cardiac arrest	103.13	12.20	170	38089	104765	90485423
Vasoplegia syndrome	98.37	12.20	39	38220	2775	90587413
Electrocardiogram QT prolonged	97.65	12.20	136	38123	72320	90517868
Pericarditis	96.80	12.20	4	38255	270147	90320041
Arthropathy	96.02	12.20	19	38240	366223	90223965
Cryopyrin associated periodic syndrome	91.42	12.20	25	38234	543	90589645
Distributive shock	84.43	12.20	37	38222	3387	90586801
Wound	80.92	12.20	15	38244	302965	90287223
Duodenal ulcer perforation	80.21	12.20	3	38256	221285	90368903
Hyperglycaemia	79.89	12.20	103	38156	50867	90539321
Nodal rhythm	77.10	12.20	29	38230	1789	90588399
Hepatic enzyme increased	77.07	12.20	28	38231	360708	90229480
Extrapyramidal disorder	72.54	12.20	58	38201	16245	90573943
Atrial fibrillation	70.84	12.20	167	38092	133444	90456744
Labelled drug-drug interaction medication error	69.45	12.20	54	38205	14528	90575660
Lower respiratory tract infection	67.81	12.20	12	38247	250647	90339541
Rhythm idioventricular	66.26	12.20	18	38241	381	90589807
Impaired healing	66.06	12.20	10	38249	234189	90355999
Swelling	62.68	12.20	51	38208	419007	90171181
Irritable bowel syndrome	60.51	12.20	8	38251	207440	90382748
Acute kidney injury	59.27	12.20	280	37979	320107	90270081
Therapeutic product effect decreased	58.50	12.20	22	38237	277549	90312639
Fear of disease	57.04	12.20	22	38237	1454	90588734
Type 2 diabetes mellitus	56.58	12.20	9	38250	203235	90386953
Rash	54.08	12.20	165	38094	795935	89794253
Nodal arrhythmia	52.42	12.20	20	38239	1283	90588905
Atrioventricular block second degree	52.24	12.20	29	38230	4423	90585765
Rheumatoid arthritis	51.92	12.20	46	38213	362568	90227620
Cardiac failure congestive	51.90	12.20	123	38136	98571	90491617
Alopecia	51.43	12.20	81	38178	494990	90095198
Liver injury	51.15	12.20	6	38253	170561	90419627
Abdominal discomfort	50.63	12.20	77	38182	477251	90112937
Coma	50.13	12.20	101	38158	72531	90517657
Acute lung injury	49.72	12.20	20	38239	1478	90588710
Bundle branch block right	49.34	12.20	30	38229	5423	90584765
Contraindicated product administered	49.06	12.20	38	38221	320101	90270087
Cardiac failure	47.67	12.20	127	38132	109369	90480819
Discomfort	46.76	12.20	29	38230	274306	90315882
Hyperkalaemia	45.62	12.20	91	38168	64873	90525315
Suicide attempt	45.23	12.20	99	38160	75300	90514888
Rhabdomyolysis	44.99	12.20	79	38180	51177	90539011
Blister	44.80	12.20	26	38233	254972	90335216
Large intestine polyp	43.06	12.20	34	38225	9352	90580836
Blood cholesterol increased	42.96	12.20	17	38242	207995	90382193
Medication overuse headache	42.88	12.20	18	38241	1483	90588705
Joint range of motion decreased	42.65	12.20	4	38255	135639	90454549
Suspected suicide	42.48	12.20	34	38225	9534	90580654
Atrioventricular dissociation	40.89	12.20	11	38248	224	90589964
Arrhythmia	40.78	12.20	68	38191	42264	90547924
Cardio-respiratory arrest	40.27	12.20	85	38174	63055	90527133
Cough	40.18	12.20	280	37979	368682	90221506
Non-cardiogenic pulmonary oedema	39.45	12.20	16	38243	1208	90588980
Mobility decreased	39.38	12.20	29	38230	250705	90339483
Tongue oedema	39.34	12.20	26	38233	5428	90584760
Hypoglobulinaemia	38.93	12.20	10	38249	169	90590019
Drug intolerance	38.65	12.20	82	38177	447509	90142679
Device pacing issue	38.53	12.20	9	38250	100	90590088
Lactic acidosis	38.25	12.20	73	38186	50390	90539798
Myocardial stunning	37.77	12.20	11	38248	302	90589886
Sinus node dysfunction	37.11	12.20	25	38234	5387	90584801
Gastrointestinal disorder	36.20	12.20	33	38226	256654	90333534
Reversible cerebral vasoconstriction syndrome	35.52	12.20	22	38237	4108	90586080
Supraventricular tachycardia	35.48	12.20	39	38220	16297	90573891
Respiratory depression	35.25	12.20	38	38221	15537	90574651
Sleep disorder	35.05	12.20	20	38239	198010	90392178
Pain	34.92	12.20	262	37997	996079	89594109
Injury	34.83	12.20	20	38239	197329	90392859
Ill-defined disorder	33.69	12.20	18	38241	184873	90405315
Melaena	33.65	12.20	56	38203	34741	90555447
Myocardial ischaemia	33.57	12.20	35	38224	13779	90576409
Night sweats	33.04	12.20	7	38252	128759	90461429
Product coating issue	32.75	12.20	8	38251	109	90590079
Body temperature decreased	32.51	12.20	45	38214	23771	90566417
Bursitis	32.10	12.20	8	38251	131646	90458542
Pulmonary fibrosis	31.69	12.20	4	38255	107499	90482689
Wound infection	31.27	12.20	4	38255	106398	90483790
Hypersensitivity	30.96	12.20	94	38165	454583	90135605
Mycobacterium tuberculosis complex test positive	30.61	12.20	17	38242	2595	90587593
Anion gap	30.31	12.20	13	38246	1129	90589059
Pulseless electrical activity	29.93	12.20	27	38232	8905	90581283
Cerebrovascular accident	29.75	12.20	117	38142	123416	90466772
Musculoskeletal stiffness	29.37	12.20	50	38209	296482	90293706
Hypercholesterolaemia	29.15	12.20	4	38255	100888	90489300
Maternal exposure during pregnancy	28.60	12.20	69	38190	359994	90230194
Fibromyalgia	28.51	12.20	27	38232	206242	90383946
Syncope	28.27	12.20	121	38138	132542	90457646
Electrolyte imbalance	28.21	12.20	42	38217	23703	90566485
Clinically isolated syndrome	28.17	12.20	6	38253	42	90590146
Product used for unknown indication	28.11	12.20	11	38248	756	90589432
Infection	27.50	12.20	71	38188	362023	90228165
Acquired apparent mineralocorticoid excess	27.18	12.20	5	38254	14	90590174
Cardiac complication associated with device	27.08	12.20	4	38255	0	90590188
Psoriatic arthropathy	27.01	12.20	34	38225	228301	90361887
Cardiac failure acute	26.81	12.20	29	38230	11900	90578288
Rubber sensitivity	26.68	12.20	16	38243	2821	90587367
Accidental overdose	26.67	12.20	45	38214	28228	90561960
Mental status changes	26.03	12.20	58	38201	44621	90545567
Ventricular extrasystoles	25.99	12.20	30	38229	13220	90576968
Facet joint syndrome	25.97	12.20	5	38254	98384	90491804
Neonatal respiratory distress	25.67	12.20	10	38249	679	90589509
Ventricular dyssynchrony	25.19	12.20	6	38253	73	90590115
Communication disorder	24.60	12.20	16	38243	3250	90586938
Depressed level of consciousness	24.49	12.20	77	38182	72707	90517481
Gait inability	24.23	12.20	16	38243	146440	90443748
Product monitoring error	24.22	12.20	18	38241	4526	90585662
Renal impairment	23.90	12.20	98	38161	105323	90484865
Poisoning deliberate	23.79	12.20	32	38227	16454	90573734
Road traffic accident	23.56	12.20	8	38251	107618	90482570
Cluster headache	23.56	12.20	10	38249	847	90589341
Mixed liver injury	23.51	12.20	22	38237	7601	90582587
Breast pain	22.85	12.20	25	38234	10393	90579795
Therapeutic product effect incomplete	22.80	12.20	29	38230	193867	90396321
Peripheral venous disease	22.72	12.20	4	38255	83917	90506271
Death	22.17	12.20	292	37967	456259	90133929
Sinoatrial block	22.03	12.20	10	38249	995	90589193
Stomatitis	21.52	12.20	53	38206	274645	90315543
Tricuspid valve disease	21.47	12.20	7	38252	282	90589906
Productive cough	21.04	12.20	76	38183	76987	90513201
Cerebral infarction	20.80	12.20	39	38220	26557	90563631
Somnolence	20.60	12.20	155	38104	208929	90381259
Pulmonary oedema	20.27	12.20	65	38194	62015	90528173
Hyponatraemic syndrome	20.22	12.20	8	38251	566	90589622
Red blood cell sedimentation rate increased	20.17	12.20	5	38254	82590	90507598
Intentional product misuse	20.08	12.20	83	38176	89521	90500667
Autoimmune disorder	20.04	12.20	4	38255	76740	90513448
Blood pressure decreased	19.72	12.20	73	38186	74822	90515366
Pallor	19.51	12.20	44	38215	34121	90556067
C-reactive protein increased	19.45	12.20	29	38230	181360	90408828
Hypoaesthesia	19.26	12.20	68	38191	314142	90276046
Multiple organ dysfunction syndrome	19.18	12.20	68	38191	68268	90521920
Anaemia vitamin B12 deficiency	19.00	12.20	8	38251	664	90589524
Low cardiac output syndrome	18.70	12.20	7	38252	426	90589762
Hypotonia neonatal	18.68	12.20	10	38249	1420	90588768
Exposure during pregnancy	18.67	12.20	46	38213	238364	90351824
Blood phosphorus decreased	18.43	12.20	16	38243	5018	90585170
Hip fracture	18.23	12.20	42	38217	33035	90557153
Placental calcification	17.99	12.20	4	38255	35	90590153
Hyponatraemia	17.98	12.20	107	38152	133431	90456757
Cholestatic liver injury	17.95	12.20	14	38245	3783	90586405
Stress	17.93	12.20	75	38184	81320	90508868
Hip arthroplasty	17.87	12.20	5	38254	76203	90513985
Fall	17.82	12.20	294	37965	481516	90108672
Musculoskeletal pain	17.76	12.20	28	38231	171223	90418965
Intentional product use issue	17.65	12.20	41	38218	216851	90373337
Pyrexia	17.64	12.20	186	38073	660299	89929889
Weight increased	17.53	12.20	104	38155	417823	90172365
Lower limb fracture	17.46	12.20	7	38252	85006	90505182
Bundle branch block left	17.43	12.20	19	38240	7866	90582322
Sinus arrest	17.37	12.20	11	38248	2135	90588053
Prescribed overdose	17.06	12.20	10	38249	97615	90492573
Arthralgia	17.05	12.20	229	38030	778293	89811895
Ventricular fibrillation	16.91	12.20	25	38234	14019	90576169
Coma scale abnormal	16.90	12.20	16	38243	5610	90584578
Apraxia	16.84	12.20	11	38248	2251	90587937
Myalgia	16.78	12.20	129	38130	174996	90415192
Breast enlargement	16.77	12.20	10	38249	1745	90588443
Ischaemic stroke	16.71	12.20	32	38227	22134	90568054
Alkalosis	16.67	12.20	7	38252	577	90589611
Delirium	16.46	12.20	12	38247	104347	90485841
Normocytic anaemia	16.46	12.20	12	38247	2932	90587256
Hypokalaemia	16.35	12.20	103	38156	131013	90459175
Cardiotoxicity	16.27	12.20	22	38237	11367	90578821
Dizziness	16.06	12.20	343	37916	588941	90001247
Bleeding varicose vein	16.03	12.20	6	38253	365	90589823
Respiratory failure	16.01	12.20	95	38164	118323	90471865
Inflammation	15.99	12.20	32	38227	178560	90411628
Cerebral haemorrhage	15.99	12.20	41	38218	34481	90555707
Metastases to retroperitoneum	15.96	12.20	5	38254	177	90590011
Osteoarthritis	15.93	12.20	37	38222	195693	90394495
Interstitial lung disease	15.74	12.20	69	38190	76336	90513852
Exfoliative rash	15.59	12.20	12	38247	3180	90587008
Dyspnoea	15.58	12.20	484	37775	880471	89709717
Blood pressure immeasurable	15.57	12.20	9	38250	1483	90588705
Renal tubular disorder	15.54	12.20	12	38247	3195	90586993
Poisoning	15.40	12.20	25	38234	15192	90574996
Salivary gland calculus	15.32	12.20	5	38254	202	90589986
Circulatory collapse	15.27	12.20	33	38226	24871	90565317
Type III immune complex mediated reaction	15.27	12.20	6	38253	417	90589771
Interspinous osteoarthritis	15.13	12.20	4	38255	76	90590112
Hepatocellular injury	15.11	12.20	36	38223	28922	90561266
Embolic stroke	15.02	12.20	13	38246	4059	90586129
Palpitations	14.98	12.20	104	38155	136624	90453564
Stress cardiomyopathy	14.98	12.20	23	38236	13332	90576856
Product physical issue	14.95	12.20	15	38244	5645	90584543
Frequent bowel movements	14.80	12.20	3	38256	56932	90533256
Pregnancy	14.68	12.20	4	38255	62043	90528145
Urticaria	14.65	12.20	75	38184	312659	90277529
Hypertrophic cardiomyopathy	14.58	12.20	10	38249	2218	90587970
Tachycardia	14.48	12.20	115	38144	157558	90432630
Gallbladder oedema	14.46	12.20	5	38254	242	90589946
Dislocation of vertebra	14.44	12.20	3	38256	55965	90534223
Obesity	14.35	12.20	14	38245	105493	90484695
Conduction disorder	14.31	12.20	9	38250	1726	90588462
Blepharospasm	14.25	12.20	3	38256	55442	90534746
Atrial flutter	14.19	12.20	20	38239	10738	90579450
Malabsorption	14.19	12.20	14	38245	5164	90585024
Pneumonia chlamydial	14.09	12.20	4	38255	100	90590088
Dry mouth	14.03	12.20	36	38223	184023	90406165
Tachycardia induced cardiomyopathy	13.98	12.20	4	38255	103	90590085
Live birth	13.97	12.20	8	38251	79099	90511089
Chronic obstructive pulmonary disease	13.96	12.20	65	38194	73764	90516424
Hypoxia	13.88	12.20	64	38195	72335	90517853
Loss of consciousness	13.83	12.20	104	38155	140134	90450054
Nasopharyngitis	13.74	12.20	108	38151	406996	90183192
Rhabdomyosarcoma	13.70	12.20	4	38255	111	90590077
Febrile neutropenia	13.65	12.20	29	38230	158320	90431868
Blood pressure diastolic decreased	13.63	12.20	33	38226	26793	90563395
Epilepsy	13.57	12.20	9	38250	82197	90507991
Toxic skin eruption	13.43	12.20	24	38235	15750	90574438
Loss of personal independence in daily activities	13.42	12.20	23	38236	136082	90454106
Haemarthrosis	13.24	12.20	12	38247	3982	90586206
Hepatitis A antibody abnormal	13.12	12.20	4	38255	129	90590059
Malignant neoplasm of ampulla of Vater	12.87	12.20	3	38256	33	90590155
Haemorrhage subcutaneous	12.85	12.20	11	38248	3385	90586803
Periorbital oedema	12.68	12.20	15	38244	6784	90583404
Myoclonus	12.44	12.20	26	38233	19142	90571046
Ventricular arrhythmia	12.43	12.20	12	38247	4309	90585879
Anion gap abnormal	12.41	12.20	5	38254	371	90589817
Subacute cutaneous lupus erythematosus	12.34	12.20	11	38248	3571	90586617
Heart rate decreased	12.33	12.20	50	38209	53455	90536733
Confusional state	12.33	12.20	104	38155	386101	90204087
Epidermolysis	12.29	12.20	6	38253	703	90589485
Herbal interaction	12.27	12.20	4	38255	161	90590027

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	620.37	13.50	453	20517	96012	42504353
Cardiogenic shock	312.51	13.50	203	20767	35437	42564928
Bradycardia	309.59	13.50	288	20682	85196	42515169
Toxicity to various agents	184.06	13.50	370	20600	228766	42371599
Hypotension	158.89	13.50	374	20596	257257	42343108
Intentional overdose	153.39	13.50	156	20814	51300	42549065
Shock	108.80	13.50	100	20870	29021	42571344
Atrioventricular block complete	107.57	13.50	68	20902	11296	42589069
Brain scan abnormal	103.36	13.50	34	20936	1205	42599160
Cerebral artery thrombosis	103.09	13.50	34	20936	1215	42599150
Nodal rhythm	90.75	13.50	33	20937	1584	42598781
Drug interaction	82.31	13.50	303	20667	266696	42333669
Areflexia	81.94	13.50	39	20931	3704	42596661
Hemiplegia	69.24	13.50	45	20925	7834	42592531
Overdose	66.96	13.50	155	20815	105109	42495256
Vasoplegia syndrome	59.14	13.50	28	20942	2627	42597738
Coma	50.74	13.50	93	20877	53461	42546904
Febrile neutropenia	49.40	13.50	15	20955	185688	42414677
Ischaemic stroke	46.44	13.50	56	20914	22177	42578188
Acute respiratory distress syndrome	44.53	13.50	64	20906	30044	42570321
BRASH syndrome	42.98	13.50	20	20950	1805	42598560
Compartment syndrome	42.35	13.50	24	20946	3265	42597100
Facial paralysis	39.05	13.50	39	20931	12524	42587841
Cardiac arrest	37.77	13.50	129	20841	109191	42491174
Nodular melanoma	36.46	13.50	10	20960	187	42600178
Pacemaker generated rhythm	35.62	13.50	8	20962	62	42600303
Coma scale abnormal	35.11	13.50	24	20946	4541	42595824
Oesophageal ulcer haemorrhage	33.93	13.50	11	20959	372	42599993
Sinus bradycardia	33.64	13.50	39	20931	14814	42585551
Hyperkalaemia	33.28	13.50	101	20869	80357	42520008
Antiacetylcholine receptor antibody positive	32.62	13.50	8	20962	94	42600271
Prostatic adenoma	32.11	13.50	9	20961	183	42600182
Pseudomonal sepsis	31.88	13.50	22	20948	4227	42596138
Bundle branch block left	31.78	13.50	26	20944	6450	42593915
Cerebral haematoma	30.68	13.50	24	20946	5586	42594779
Respiratory distress	30.39	13.50	65	20905	41755	42558610
Pulse absent	30.21	13.50	25	20945	6302	42594063
Atrioventricular block first degree	29.65	13.50	25	20945	6466	42593899
Suicide attempt	29.39	13.50	68	20902	46032	42554333
Supraventricular tachycardia	28.81	13.50	33	20937	12375	42587990
Lactic acidosis	28.02	13.50	66	20904	45195	42555170
Cerebral infarction	26.86	13.50	52	20918	31117	42569248
Lip discolouration	26.79	13.50	8	20962	205	42600160
Rhythm idioventricular	26.71	13.50	9	20961	344	42600021
Electrocardiogram QT prolonged	26.58	13.50	67	20903	47878	42552487
Embolic stroke	26.35	13.50	21	20949	5019	42595346
Neuromyopathy	25.38	13.50	12	20958	1122	42599243
Poisoning deliberate	25.32	13.50	28	20942	10106	42590259
Nodal arrhythmia	24.80	13.50	11	20959	888	42599477
Disease progression	24.25	13.50	21	20949	143635	42456730
Superinfection	23.85	13.50	16	20954	2935	42597430
Left ventricle outflow tract obstruction	23.60	13.50	7	20963	175	42600190
Pyrexia	23.46	13.50	107	20863	393935	42206430
Xanthelasma	23.18	13.50	6	20964	89	42600276
Cluster headache	22.62	13.50	9	20961	553	42599812
Mallory-Weiss syndrome	22.05	13.50	12	20958	1509	42598856
Cardiorenal syndrome	21.69	13.50	10	20960	883	42599482
Haemodynamic instability	20.50	13.50	28	20942	12529	42587836
Hepatocellular injury	19.79	13.50	39	20931	23639	42576726
Therapeutic drug monitoring analysis incorrectly performed	19.62	13.50	7	20963	318	42600047
Foetal growth restriction	19.44	13.50	18	20952	5265	42595100
Victim of crime	19.44	13.50	8	20962	537	42599828
Alkalosis hypochloraemic	19.41	13.50	7	20963	328	42600037
Antineutrophil cytoplasmic antibody increased	18.99	13.50	4	20966	22	42600343
Suspected suicide	18.81	13.50	19	20951	6180	42594185
Labelled drug-drug interaction medication error	18.61	13.50	30	20940	15552	42584813
Tobacco abuse	18.44	13.50	8	20962	612	42599753
Atrial fibrillation	18.02	13.50	124	20846	139469	42460896
Dyspnoea	17.80	13.50	311	20659	442310	42158055
Acute kidney injury	17.71	13.50	266	20704	367071	42233294
Palpitations	17.57	13.50	60	20910	50737	42549628
Neutrophil count decreased	17.06	13.50	5	20965	63410	42536955
Disease recurrence	16.99	13.50	42	20928	29636	42570729
Defect conduction intraventricular	16.95	13.50	7	20963	474	42599891
Pallor	16.67	13.50	41	20929	28845	42571520
Lymphoedema	16.57	13.50	16	20954	4932	42595433
Atrioventricular block	16.55	13.50	22	20948	9593	42590772
Tachycardia	16.26	13.50	95	20875	100992	42499373
Atrioventricular dissociation	16.12	13.50	5	20965	146	42600219
Hyperthermia	16.11	13.50	25	20945	12549	42587816
Arrhythmia	16.08	13.50	50	20920	40267	42560098
Normochromic normocytic anaemia	16.07	13.50	21	20949	9010	42591355
Sudden death	15.89	13.50	29	20941	16600	42583765
Cardio-respiratory arrest	15.87	13.50	64	20906	58572	42541793
Neutropenia	15.86	13.50	48	20922	199383	42400982
Disturbance in attention	15.78	13.50	41	20929	29825	42570540
Pancytopenia	15.65	13.50	21	20949	117722	42482643
Prothrombin time ratio decreased	15.58	13.50	7	20963	582	42599783
Erythromelalgia	15.47	13.50	4	20966	59	42600306
Pain	15.44	13.50	65	20905	244783	42355582
Heart rate abnormal	15.42	13.50	11	20959	2228	42598137
Diarrhoea	15.33	13.50	149	20821	460700	42139665
Neck injury	15.24	13.50	9	20961	1322	42599043
Hyperparathyroidism primary	15.23	13.50	5	20965	176	42600189
Myofascial pain syndrome	15.20	13.50	6	20964	361	42600004
Acidosis	15.16	13.50	24	20946	12255	42588110
COVID-19	15.09	13.50	21	20949	115927	42484438
Mucosal inflammation	15.03	13.50	3	20967	49371	42550994
Drug diversion	14.90	13.50	8	20962	979	42599386
Anuria	14.87	13.50	23	20947	11509	42588856
Wrong patient received product	14.74	13.50	13	20957	3570	42596795
Hypoparathyroidism secondary	14.64	13.50	5	20965	199	42600166
Unresponsive to stimuli	14.48	13.50	41	20929	31362	42569003
Hypertrophic cardiomyopathy	14.44	13.50	9	20961	1456	42598909
Anaphylactic reaction	14.35	13.50	50	20920	42693	42557672
Gravitational oedema	14.35	13.50	7	20963	701	42599664
Sinus rhythm	14.30	13.50	6	20964	423	42599942
Altered state of consciousness	14.28	13.50	39	20931	29220	42571145
Ileus	14.19	13.50	30	20940	19109	42581256
Hyperlactacidaemia	14.00	13.50	14	20956	4502	42595863
Nervous system disorder	13.98	13.50	28	20942	17167	42583198
Thalamus haemorrhage	13.96	13.50	8	20962	1111	42599254
Rebound tachycardia	13.89	13.50	3	20967	19	42600346
Vascular resistance systemic decreased	13.72	13.50	4	20966	94	42600271
Haemoglobin decreased	13.55	13.50	28	20942	132443	42467922

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1812.16	11.78	1240	52332	241141	110294586
Bradycardia	899.28	11.78	682	52890	154835	110380892
Cardiogenic shock	704.03	11.78	403	53169	56935	110478792
Toxicity to various agents	642.19	11.78	963	52609	479592	110056135
Hypotension	535.94	11.78	930	52642	522919	110012808
Atrioventricular block complete	451.40	11.78	212	53360	19870	110515857
Drug interaction	426.36	11.78	821	52751	499362	110036365
BRASH syndrome	381.47	11.78	119	53453	3604	110532123
Intentional overdose	312.01	11.78	352	53220	132149	110403578
Overdose	253.87	11.78	427	53145	233367	110302360
Shock	218.40	11.78	192	53380	53396	110482331
Atrioventricular block	216.05	11.78	122	53450	16755	110518972
Nodal rhythm	164.22	11.78	62	53510	3361	110532366
Anuria	158.81	11.78	115	53457	24226	110511501
Metabolic acidosis	156.03	11.78	216	53356	99528	110436199
Neovascularisation	155.10	11.78	50	53522	1687	110534040
Vasoplegia syndrome	152.48	11.78	67	53505	5372	110530355
Acute respiratory distress syndrome	147.23	11.78	154	53418	53044	110482683
Cardiac arrest	143.16	11.78	303	53269	196450	110339277
Atrioventricular block first degree	133.00	11.78	84	53488	14141	110521586
Sinus bradycardia	130.98	11.78	111	53461	29372	110506355
Electrocardiogram QT prolonged	123.44	11.78	203	53369	108757	110426970
Coma	120.81	11.78	210	53362	117659	110418068
Synovitis	114.92	11.78	4	53568	274088	110261639
Joint swelling	105.96	11.78	41	53531	442804	110092923
Electrocardiogram QRS complex prolonged	104.82	11.78	70	53502	12951	110522776
Drug ineffective for unapproved indication	101.20	11.78	180	53392	102658	110433069
Infusion related reaction	96.78	11.78	32	53540	381130	110154597
Brain scan abnormal	92.17	11.78	33	53539	1538	110534189
Systemic lupus erythematosus	90.78	11.78	9	53563	254329	110281398
Rhythm idioventricular	88.48	11.78	27	53545	758	110534969
Distributive shock	87.45	11.78	47	53525	5857	110529870
Glossodynia	87.30	11.78	5	53567	221999	110313728
Pemphigus	87.01	11.78	4	53568	214566	110321161
Cerebral artery thrombosis	86.54	11.78	32	53540	1636	110534091
Cryopyrin associated periodic syndrome	85.65	11.78	25	53547	600	110535127
Arthropathy	84.59	11.78	18	53554	287504	110248223
Hepatic enzyme increased	81.34	11.78	27	53545	320865	110214862
Pericarditis	77.55	11.78	8	53564	219106	110316621
Paradoxical drug reaction	74.77	11.78	51	53521	9766	110525961
Labelled drug-drug interaction medication error	74.31	11.78	81	53491	29221	110506506
Duodenal ulcer perforation	73.08	11.78	3	53569	177697	110358030
Atrial fibrillation	72.18	11.78	260	53312	229382	110306345
Nodal arrhythmia	71.41	11.78	30	53542	2154	110533573
Hyperglycaemia	70.06	11.78	138	53434	84952	110450775
Hyperkalaemia	67.09	11.78	180	53392	135616	110400111
Swelling	66.72	11.78	44	53528	350997	110184730
Lower respiratory tract infection	66.05	11.78	18	53554	243088	110292639
Cardio-respiratory arrest	64.92	11.78	161	53411	115675	110420052
Suicide attempt	64.71	11.78	150	53422	103244	110432483
Wound	62.50	11.78	18	53554	234419	110301308
Folliculitis	62.33	11.78	5	53567	167648	110368079
Acute kidney injury	61.95	11.78	522	53050	634908	109900819
Areflexia	60.86	11.78	39	53533	6730	110528997
Lactic acidosis	60.69	11.78	137	53435	92674	110443053
Supraventricular tachycardia	59.31	11.78	66	53506	24356	110511371
Febrile neutropenia	58.46	11.78	41	53531	316726	110219001
Irritable bowel syndrome	58.09	11.78	6	53566	164209	110371518
Ischaemic stroke	58.06	11.78	85	53487	41178	110494549
Therapeutic product effect decreased	56.14	11.78	24	53548	244292	110291435
Fear of disease	55.31	11.78	22	53550	1373	110534354
Atrioventricular dissociation	55.05	11.78	16	53556	378	110535349
Rheumatoid arthritis	53.69	11.78	40	53532	299573	110236154
Suspected suicide	51.25	11.78	49	53523	15150	110520577
Non-cardiogenic pulmonary oedema	51.00	11.78	23	53549	1961	110533766
Impaired healing	50.80	11.78	16	53556	196701	110339026
Type 2 diabetes mellitus	50.29	11.78	12	53560	177220	110358507
Coma scale abnormal	50.28	11.78	40	53532	9686	110526041
Cerebral infarction	50.03	11.78	90	53482	51748	110483979
Blood cholesterol increased	49.59	11.78	14	53558	184771	110350956
Sinus node dysfunction	48.47	11.78	38	53534	9009	110526718
Pain	48.12	11.78	269	53303	954686	109581041
Alopecia	47.82	11.78	64	53508	364689	110171038
Atrioventricular block second degree	47.41	11.78	36	53536	8145	110527582
Cardiac failure	46.39	11.78	197	53375	187429	110348298
Poisoning deliberate	45.68	11.78	60	53512	26271	110509456
Musculoskeletal stiffness	45.61	11.78	41	53531	279781	110255946
Liver injury	45.08	11.78	9	53563	150404	110385323
Hypoglobulinaemia	44.32	11.78	12	53560	217	110535510
Rhabdomyolysis	42.74	11.78	142	53430	120259	110415468
Bundle branch block left	42.42	11.78	41	53531	12847	110522880
Mobility decreased	42.14	11.78	32	53540	237390	110298337
Embolic stroke	41.06	11.78	34	53538	8709	110527018
Cardiac failure congestive	40.03	11.78	162	53410	150838	110384889
Extrapyramidal disorder	39.94	11.78	59	53513	28808	110506919
Medication overuse headache	39.79	11.78	18	53554	1545	110534182
Fibromyalgia	38.92	11.78	17	53555	170892	110364835
Gastrointestinal disorder	38.77	11.78	36	53536	241916	110293811
Bursitis	38.46	11.78	8	53564	129910	110405817
Bundle branch block right	38.40	11.78	38	53534	12253	110523474
Arrhythmia	38.23	11.78	96	53476	69479	110466248
Discomfort	38.02	11.78	29	53543	214678	110321049
Cluster headache	37.54	11.78	16	53556	1191	110534536
Pulseless electrical activity	36.82	11.78	43	53529	16714	110519013
Compartment syndrome	36.46	11.78	27	53545	5883	110529844
Cerebrovascular accident	36.37	11.78	179	53393	181105	110354622
Facial paralysis	35.70	11.78	51	53521	24163	110511564
Acute lung injury	35.58	11.78	21	53551	3130	110532597
Prostatic adenoma	35.52	11.78	9	53563	124	110535603
Pacemaker generated rhythm	35.30	11.78	8	53564	66	110535661
Myocardial stunning	35.19	11.78	11	53561	335	110535392
Infection	35.13	11.78	77	53495	362123	110173604
Syncope	35.10	11.78	192	53380	202344	110333383
Sinoatrial block	34.56	11.78	16	53556	1449	110534278
Hepatocellular injury	34.49	11.78	76	53496	50566	110485161
Product monitoring error	34.39	11.78	31	53541	8896	110526831
Altered state of consciousness	34.30	11.78	82	53490	57544	110478183
Hemiplegia	33.61	11.78	48	53524	22734	110512993
Pulse absent	33.60	11.78	34	53538	11258	110524469
Hypertrophic cardiomyopathy	32.92	11.78	20	53552	3143	110532584
Nodular melanoma	32.90	11.78	10	53562	277	110535450
Injury	32.61	11.78	23	53549	177242	110358485
Amaurosis fugax	32.55	11.78	18	53554	2372	110533355
Tongue oedema	32.46	11.78	29	53543	8227	110527500
Tachycardia	32.26	11.78	204	53368	226441	110309286
Haemodynamic instability	31.98	11.78	47	53525	22841	110512886
Pyrexia	31.92	11.78	280	53292	897985	109637742
Disease progression	31.78	11.78	43	53529	243991	110291736
Abdominal discomfort	31.78	11.78	92	53480	393766	110141961
Night sweats	31.03	11.78	13	53559	133970	110401757
Road traffic accident	31.00	11.78	7	53565	107391	110428336
Product coating issue	30.94	11.78	8	53564	120	110535607
Rash	30.92	11.78	252	53320	820712	109715015
Facet joint syndrome	30.73	11.78	5	53567	96823	110438904
Ill-defined disorder	30.68	11.78	19	53553	156834	110378893
Dry mouth	30.58	11.78	31	53541	199917	110335810
Hypercholesterolaemia	30.43	11.78	4	53568	90833	110444894
Weight increased	30.35	11.78	103	53469	419541	110116186
Left ventricle outflow tract obstruction	30.33	11.78	11	53561	532	110535195
Large intestine polyp	30.27	11.78	37	53535	15080	110520647
Pallor	30.07	11.78	77	53495	56390	110479337
Hypersensitivity	30.01	11.78	98	53474	403900	110131827
Peripheral venous disease	29.94	11.78	3	53569	84114	110451613
Reversible cerebral vasoconstriction syndrome	29.93	11.78	22	53550	4739	110530988
Myelosuppression	29.65	11.78	5	53567	94335	110441392
Sleep disorder	29.04	11.78	32	53540	198612	110337115
Blister	28.67	11.78	41	53531	227335	110308392
Myocardial ischaemia	27.91	11.78	48	53524	26636	110509091
Respiratory failure	27.71	11.78	189	53383	215143	110320584
Oesophageal ulcer haemorrhage	27.57	11.78	12	53560	940	110534787
Cough	27.48	11.78	343	53229	461298	110074429
Rubber sensitivity	27.01	11.78	16	53556	2402	110533325
Acidosis	26.88	11.78	43	53529	22488	110513239
Drug intolerance	26.61	11.78	104	53468	406408	110129319
Cardiac complication associated with device	26.53	11.78	4	53568	0	110535727
Clinically isolated syndrome	26.53	11.78	6	53566	49	110535678
Wound infection	26.46	11.78	7	53565	96458	110439269
Intentional product use issue	26.33	11.78	50	53522	247856	110287871
Psoriatic arthropathy	26.30	11.78	34	53538	196727	110339000
Low cardiac output syndrome	25.84	11.78	12	53560	1094	110534633
Mycobacterium tuberculosis complex test positive	24.85	11.78	17	53555	3271	110532456
Antiacetylcholine receptor antibody positive	24.75	11.78	8	53564	272	110535455
Contraindicated product administered	24.71	11.78	52	53520	248215	110287512
Device pacing issue	24.35	11.78	7	53565	159	110535568
Pulmonary oedema	24.33	11.78	105	53467	100554	110435173
Dyspnoea	23.87	11.78	703	52869	1106169	109429558
Gait inability	23.41	11.78	19	53553	136357	110399370
Mixed liver injury	23.27	11.78	29	53543	12050	110523677
Obesity	23.20	11.78	13	53559	113338	110422389
Neuromyopathy	23.14	11.78	13	53559	1766	110533961
Sinus arrest	23.12	11.78	18	53554	4224	110531503
Ventricular dyssynchrony	23.08	11.78	6	53566	92	110535635
Osteoarthritis	22.95	11.78	33	53539	182590	110353137
Stomatitis	22.62	11.78	62	53510	270180	110265547
Breast pain	22.54	11.78	26	53546	9974	110525753
Poisoning	22.51	11.78	46	53526	29059	110506668
Maternal exposure during pregnancy	22.45	11.78	57	53515	254826	110280901
C-reactive protein increased	22.23	11.78	45	53527	217874	110317853
Periorbital oedema	22.14	11.78	26	53546	10166	110525561
Hypoaesthesia	22.12	11.78	78	53494	314145	110221582
Frequent bowel movements	21.96	11.78	4	53568	71386	110464341
Urticaria	21.88	11.78	80	53492	318777	110216950
Blood pressure immeasurable	21.88	11.78	14	53558	2409	110533318
Neutrophil count decreased	21.84	11.78	16	53556	120925	110414802
Anion gap	21.82	11.78	13	53559	1972	110533755
Cerebral haematoma	21.63	11.78	25	53547	9607	110526120
Therapeutic product effect incomplete	21.34	11.78	48	53524	223757	110311970
Melaena	20.85	11.78	77	53495	68680	110467047
Internal haemorrhage	20.73	11.78	25	53547	10046	110525681
Malignant neoplasm progression	20.54	11.78	33	53539	174534	110361193
Body temperature decreased	20.32	11.78	51	53521	36884	110498843
Musculoskeletal pain	20.24	11.78	36	53536	182987	110352740
Pancytopenia	19.95	11.78	45	53527	209568	110326159
Acute myocardial infarction	19.95	11.78	87	53485	83690	110452037
Haematoma	19.89	11.78	68	53504	58408	110477319
Xanthelasma	19.85	11.78	6	53566	163	110535564
Pseudomonal sepsis	19.52	11.78	23	53549	9023	110526704
Arthralgia	19.26	11.78	264	53308	779368	109756359
Electrolyte imbalance	19.20	11.78	50	53522	36978	110498749
Respiratory distress	19.13	11.78	75	53497	68799	110466928
Electrocardiogram T wave abnormal	18.98	11.78	16	53556	4201	110531526
Loss of consciousness	18.91	11.78	161	53411	196145	110339582
Alkalosis hypochloraemic	18.80	11.78	8	53564	593	110535134
Placental calcification	18.76	11.78	4	53568	24	110535703
Cardiac failure acute	18.55	11.78	38	53534	24040	110511687
Communication disorder	18.44	11.78	17	53555	5022	110530705
Head discomfort	18.35	11.78	33	53539	18967	110516760
Sciatica	18.33	11.78	11	53561	92388	110443339
Palpitations	18.30	11.78	136	53436	159076	110376651
Choking sensation	18.27	11.78	16	53556	4420	110531307
Cerebral haemorrhage	18.25	11.78	71	53501	64897	110470830
Urinary tract disorder	18.13	11.78	18	53554	5826	110529901
Acquired apparent mineralocorticoid excess	17.99	11.78	5	53567	100	110535627
Tachycardia induced cardiomyopathy	17.98	11.78	6	53566	226	110535501
Lower limb fracture	17.95	11.78	7	53565	75341	110460386
Ventricular extrasystoles	17.76	11.78	36	53536	22605	110513122
Myalgia	17.68	11.78	175	53397	222206	110313521
Autoimmune disorder	17.49	11.78	5	53567	65478	110470249
Red blood cell sedimentation rate increased	17.49	11.78	8	53564	78294	110457433
Sinusitis	17.49	11.78	79	53493	296609	110239118
Conduction disorder	17.46	11.78	15	53557	4040	110531687
Blood pressure decreased	17.24	11.78	105	53467	114986	110420741
Inflammation	17.18	11.78	43	53529	193195	110342532
Cardiotoxicity	17.18	11.78	30	53542	16851	110518876
Tricuspid valve disease	17.09	11.78	7	53565	471	110535256
Loss of personal independence in daily activities	17.05	11.78	29	53543	149991	110385736
Product used for unknown indication	16.88	11.78	11	53561	1952	110533775
Presyncope	16.76	11.78	57	53515	48830	110486897
Hyponatraemic syndrome	16.64	11.78	8	53564	789	110534938
Generalised oedema	16.48	11.78	42	53530	30662	110505065
Mallory-Weiss syndrome	16.34	11.78	13	53559	3148	110532579
Nail disorder	16.28	11.78	4	53568	57931	110477796
Nasopharyngitis	16.24	11.78	118	53454	394243	110141484
Anaemia vitamin B12 deficiency	16.05	11.78	9	53563	1218	110534509
Disturbance in attention	16.01	11.78	66	53506	61929	110473798
Multiple organ dysfunction syndrome	15.99	11.78	127	53445	151583	110384144
Renal failure	15.97	11.78	174	53398	226400	110309327
Exfoliative rash	15.90	11.78	15	53557	4559	110531168
Renal impairment	15.81	11.78	150	53422	188295	110347432
Hip fracture	15.77	11.78	45	53527	35106	110500621
Peripheral swelling	15.64	11.78	123	53449	403911	110131816
Gallbladder oedema	15.29	11.78	6	53566	361	110535366
Fall	15.13	11.78	391	53181	603091	109932636
Drug diversion	15.07	11.78	9	53563	1371	110534356
Victim of crime	15.05	11.78	9	53563	1374	110534353
Superinfection	14.73	11.78	16	53556	5747	110529980
Hypokalaemia	14.70	11.78	144	53428	182304	110353423
Cardiorenal syndrome	14.69	11.78	10	53562	1908	110533819
Circulatory collapse	14.62	11.78	50	53522	42943	110492784
Interspinous osteoarthritis	14.59	11.78	4	53568	76	110535651
Hyperthermia	14.57	11.78	32	53540	21240	110514487
Hyperlactacidaemia	14.56	11.78	19	53553	8267	110527460
Medication error	14.46	11.78	94	53478	105272	110430455
Wrong patient received product	14.45	11.78	17	53555	6657	110529070
Tobacco abuse	14.44	11.78	8	53564	1058	110534669
Therapeutic drug monitoring analysis incorrectly performed	14.42	11.78	7	53565	705	110535022
Intentional product misuse	14.41	11.78	112	53460	132792	110402935
Wrong patient	14.38	11.78	9	53563	1490	110534237
Product prescribing error	14.34	11.78	56	53516	51275	110484452
Defect conduction intraventricular	14.33	11.78	7	53565	714	110535013
Live birth	14.17	11.78	8	53564	69476	110466251
Depressed level of consciousness	14.11	11.78	98	53474	112180	110423547
Pneumonia aspiration	14.05	11.78	77	53495	81156	110454571
Atrial flutter	13.87	11.78	34	53538	24228	110511499
Contusion	13.83	11.78	62	53510	233299	110302428
Tobacco user	13.83	11.78	7	53565	771	110534956
Mental status changes	13.74	11.78	73	53499	76049	110459678
Hip arthroplasty	13.60	11.78	5	53567	55808	110479919
Alkalosis	13.60	11.78	7	53565	799	110534928
Haemorrhage subcutaneous	13.50	11.78	15	53557	5524	110530203
Hyponatraemia	13.48	11.78	163	53409	217490	110318237
Pregnancy	13.45	11.78	4	53568	51063	110484664
Haemorrhagic stroke	13.38	11.78	24	53548	13765	110521962
Accidental overdose	13.24	11.78	55	53517	51779	110483948
Platelet count decreased	13.19	11.78	62	53510	230381	110305346
Neutropenia	13.16	11.78	117	53455	374503	110161224
Ventricular fibrillation	13.15	11.78	47	53525	41266	110494461
Cytokine release syndrome	13.09	11.78	9	53563	70297	110465430
Tachyarrhythmia	13.07	11.78	18	53554	8243	110527484
Hypoparathyroidism secondary	13.02	11.78	5	53567	284	110535443
Colitis ulcerative	13.00	11.78	11	53561	77352	110458375
Muscular weakness	13.00	11.78	69	53503	248399	110287328
Delirium	12.83	11.78	29	53543	134996	110400731
Chronotropic incompetence	12.76	11.78	4	53568	123	110535604
Nervous system disorder	12.70	11.78	39	53533	31682	110504045
Taste disorder	12.67	11.78	8	53564	65379	110470348
Ocular discomfort	12.62	11.78	18	53554	8515	110527212
Hepatitis A antibody abnormal	12.58	11.78	4	53568	129	110535598
Respiratory depression	12.49	11.78	39	53533	31962	110503765
Mucosal inflammation	12.45	11.78	17	53555	96124	110439603
Dislocation of vertebra	12.32	11.78	3	53569	43718	110492009
Pneumonia chlamydial	12.29	11.78	4	53568	139	110535588
Thalamus haemorrhage	12.18	11.78	9	53563	1955	110533772
Malignant neoplasm of ampulla of Vater	12.07	11.78	3	53569	38	110535689
Respiratory arrest	11.99	11.78	58	53514	58241	110477486
Vestibular disorder	11.87	11.78	10	53562	2622	110533105
Heart rate abnormal	11.80	11.78	16	53556	7222	110528505

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Foetal growth restriction	20.04	10.92	5	3	716	113229

Pharmacologic Action:

Source	Code	Description
ATC	C08DA01	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS Phenylalkylamine derivatives
ATC	C08DA51	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS Phenylalkylamine derivatives
ATC	C09BB10	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers
FDA MoA	N0000000069	Calcium Channel Antagonists
FDA EPC	N0000175566	Calcium Channel Blocker
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D000889	Anti-Arrhythmia Agents
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D014665	Vasodilator Agents
MeSH PA	D049990	Membrane Transport Modulators
FDA MoA	N0000182141	Cytochrome P450 3A4 Inhibitors
FDA MoA	N0000185503	P-Glycoprotein Inhibitors
FDA MoA	N0000190114	Cytochrome P450 3A Inhibitors
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35476	antipsychotic agent
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35620	vasodilator agent
CHEBI has role	CHEBI:35674	antihypertensive agent
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:38070	anti-arrhythmia drug
CHEBI has role	CHEBI:38215	calcium channel blocker
CHEBI has role	CHEBI:62872	EC 1.2.3.1 (aldehyde oxidase) inhibitor
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:77255	EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor
CHEBI has role	CHEBI:77745	EC 3.4.24.18 (meprin A) inhibitor
CHEBI has role	CHEBI:77747	EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor
CHEBI has role	CHEBI:77748	EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
CHEBI has role	CHEBI:78298	environmental contaminant

Related Drugs by ATC class:

C08DA Phenylalkylamine derivatives 2 drugs

etripamil gallopamil

C09BB ACE inhibitors and calcium channel blockers 13 drugs

amlodipine benazepril delapril enalapril felodipine lercanidipine lisinopril manidipine nitrendipine perindopril ramipril trandolapril show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Atrial fibrillation	indication	49436004	DOID:0060224
Paroxysmal supraventricular tachycardia	indication	67198005
Prinzmetal angina	indication	87343002
Angina pectoris	indication	194828000
Acute coronary syndrome	indication	394659003
Prevention of Paroxysmal Supraventricular Tachycardia	indication
Cardioversion of Atrial Fibrillation	indication
Diastolic heart failure	off-label use	418304008	DOID:9775
Cluster Headache Prevention	off-label use
Hyperkalemia	contraindication	14140009
Ventricular tachycardia	contraindication	25569003
Complete atrioventricular block	contraindication	27885002
Acute cerebrovascular insufficiency	contraindication	29322000
Sick sinus syndrome	contraindication	36083008	DOID:13884
Immunosuppression	contraindication	38013005
Angioedema	contraindication	41291007	DOID:1558
Low cardiac output syndrome	contraindication	44088000
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Lown-Ganong-Levine syndrome	contraindication	55475008	DOID:13087
Aortic valve stenosis	contraindication	60573004	DOID:1712
Wolff-Parkinson-White pattern	contraindication	74390002	DOID:384
Duchenne muscular dystrophy	contraindication	76670001	DOID:11723
Transplantation	contraindication	77465005
Chronic idiopathic constipation	contraindication	82934008
Hereditary angioneurotic edema	contraindication	82966003	DOID:14735
Left heart failure	contraindication	85232009
Cardiogenic shock	contraindication	89138009
Hyponatremia	contraindication	89627008
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Disorder of connective tissue	contraindication	105969002	DOID:65
Liver function tests abnormal	contraindication	166603001
Second degree atrioventricular block	contraindication	195042002
Hypertrophic cardiomyopathy	contraindication	233873004	DOID:11984
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Renal artery stenosis	contraindication	302233006
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
First Degree Atrioventricular Heart Block	contraindication
Neuromuscular Transmission Deficiency	contraindication
Hemodialysis with High-Flux Membrane	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.91	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel	Q13936	CAC1C_HUMAN	BLOCKER	IC50	6	WOMBAT-PK	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1S	Ion channel	Q13698	CAC1S_HUMAN	BLOCKER			UNKNOWN	IUPHAR
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.66	DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	8	CHEMBL
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN	INHIBITOR	Ki	6.22	IUPHAR
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	6.52	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	6.90	DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	5.76	DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.85	PDSP
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.98	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.81	DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	7.20	DRUG MATRIX
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	5.59	DRUG MATRIX
Aldehyde oxidase	Enzyme	Q06278	AOXA_HUMAN		IC50	5.46	WOMBAT-PK
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	6.07	DRUG MATRIX
Multidrug resistance-associated protein 1	Transporter	P33527	MRP1_HUMAN		Ki	4.88	CHEMBL
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN		EC50	4.43	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN				WOMBAT-PK
G protein-activated inward rectifier potassium channel 2	Ion channel	P48051	KCNJ6_HUMAN				WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H	Ion channel	O95180	CAC1H_HUMAN	BLOCKER	Ki	4.49	WOMBAT-PK
Potassium voltage-gated channel subfamily A member 10	Ion channel	Q16322	KCA10_HUMAN	BLOCKER	IC50	4.30	IUPHAR
Potassium voltage-gated channel subfamily A member 3	Ion channel	P22001	KCNA3_HUMAN		IC50	5.10	CHEMBL
Potassium voltage-gated channel subfamily C member 2	Ion channel	Q96PR1	KCNC2_HUMAN		EC50	4.90	WOMBAT-PK
Solute carrier family 22 member 1	Transporter	O15245	S22A1_HUMAN		IC50	5.17	CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Ion channel	Q9Y3Q4	HCN4_HUMAN		IC50	4.35	WOMBAT-PK
Potassium voltage-gated channel subfamily A member 7	Ion channel	Q96RP8	KCNA7_HUMAN		Kd	4.80	WOMBAT-PK
Solute carrier family 22 member 2	Transporter	O15244	S22A2_HUMAN		IC50	4.07	WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5.48	CHEMBL
Two pore calcium channel protein 1	Ion channel	Q9ULQ1	TPC1_HUMAN	BLOCKER	IC50	4.64	IUPHAR
Equilibrative nucleoside transporter 4	Transporter	Q7RTT9	S29A4_HUMAN	INHIBITOR	Ki	4.73	IUPHAR
Two pore calcium channel protein 2	Ion channel	Q8NHX9	TPC2_HUMAN	BLOCKER	IC50	5	IUPHAR
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN				WOMBAT-PK
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	6.03	DRUG MATRIX
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	5.76	DRUG MATRIX
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	5.68	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		IC50	5.52	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel		CAC1C_RABIT		IC50	6	CHEMBL
Translocator protein	Membrane receptor		TSPO_RAT		IC50	8.85	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel		CAC1C_RAT		IC50	7.41	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1S	Ion channel		CAC1S_RAT		Ki	7.24	CHEMBL
Muscarinic acetylcholine receptor M2	GPCR		ACM2_PIG		EC50	4.51	CHEMBL
Voltage-gated L-type calcium channel	Ion channel		CAC1C_RAT CAC1D_RAT CAC1S_RAT		IC50	8.43	CHEMBL
Chloroquine resistance transporter	Transporter		CRT_PLAFA		IC50	4.52	CHEMBL
Potassium voltage-gated channel subfamily C member 2	Ion channel		KCNC2_RAT	BLOCKER	EC50	4.90	IUPHAR

External reference:

ID	Source
4019969	VUID
N0000148054	NUI
D00619	KEGG_DRUG
152-11-4	SECONDARY_CAS_RN
4018128	VANDF
4019969	VANDF
C0042523	UMLSCUI
CHEBI:9948	CHEBI
CHEMBL6966	ChEMBL_ID
CHEMBL1280	ChEMBL_ID
D014700	MESH_DESCRIPTOR_UI
DB00661	DRUGBANK_ID
2406	IUPHAR_LIGAND_ID
2122	INN_ID
CJ0O37KU29	UNII
2520	PUBCHEM_CID
11170	RXNORM
5670	MMSL
757	MMSL
d00048	MMSL
000709	NDDF
004515	NDDF
14340003	SNOMEDCT_US
372754009	SNOMEDCT_US
47898004	SNOMEDCT_US
CJ0O37KU29	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6320	CAPSULE, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6380	CAPSULE, EXTENDED RELEASE	180 mg	ORAL	ANDA	16 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6440	CAPSULE, EXTENDED RELEASE	240 mg	ORAL	ANDA	16 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9966	INJECTION, SOLUTION	2.50 mg	INTRAVENOUS	ANDA	11 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9966	INJECTION, SOLUTION	2.50 mg	INTRAVENOUS	ANDA	11 sections
VERAPAMIL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9967	INJECTION, SOLUTION	2.50 mg	INTRAVENOUS	ANDA	11 sections
VERAPAMIL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9967	INJECTION, SOLUTION	2.50 mg	INTRAVENOUS	ANDA	11 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9968	INJECTION, SOLUTION	2.50 mg	INTRAVENOUS	ANDA	12 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9968	INJECTION, SOLUTION	2.50 mg	INTRAVENOUS	ANDA	12 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1144	INJECTION, SOLUTION	2.50 mg	INTRAVENOUS	ANDA	21 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0409-1144	INJECTION, SOLUTION	2.50 mg	INTRAVENOUS	ANDA	21 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0409-4011	INJECTION, SOLUTION	2.50 mg	INTRAVENOUS	ANDA	17 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0343	TABLET, FILM COATED	80 mg	ORAL	ANDA	20 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0345	TABLET, FILM COATED	120 mg	ORAL	ANDA	20 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0591-0404	TABLET, FILM COATED	40 mg	ORAL	ANDA	20 sections
Verapamil Hydrochloride	Human Prescription Drug Label	1	0591-2880	CAPSULE, DELAYED RELEASE PELLETS	120 mg	ORAL	NDA	25 sections
Verapamil Hydrochloride	Human Prescription Drug Label	1	0591-2882	CAPSULE, DELAYED RELEASE PELLETS	180 mg	ORAL	NDA	25 sections
Verapamil Hydrochloride	Human Prescription Drug Label	1	0591-2884	CAPSULE, DELAYED RELEASE PELLETS	240 mg	ORAL	NDA	25 sections
Verapamil Hydrochloride	Human Prescription Drug Label	1	0591-2886	CAPSULE, DELAYED RELEASE PELLETS	360 mg	ORAL	NDA	25 sections
verapamil hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-035	TABLET, FILM COATED, EXTENDED RELEASE	240 mg	ORAL	ANDA	21 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-541	TABLET, FILM COATED, EXTENDED RELEASE	240 mg	ORAL	ANDA	23 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-570	TABLET, FILM COATED	120 mg	ORAL	ANDA	20 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-511	TABLET	80 mg	ORAL	ANDA	12 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-512	TABLET	120 mg	ORAL	ANDA	12 sections
Verapamil Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-868	TABLET, FILM COATED, EXTENDED RELEASE	240 mg	ORAL	ANDA	23 sections
VERAPAMIL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	23155-026	TABLET	80 mg	ORAL	ANDA	13 sections
VERAPAMIL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	23155-059	TABLET	40 mg	ORAL	ANDA	13 sections
VERAPAMIL HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	23155-486	TABLET	120 mg	ORAL	ANDA	13 sections
Verapamil hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	23155-911	INJECTION	2.50 mg	INTRAVENOUS	ANDA	12 sections
Verapamil hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	23155-912	INJECTION	2.50 mg	INTRAVENOUS	ANDA	12 sections

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verapamil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: