losartan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
angiotensin II receptor antagonists, antihypertensive (non-peptidic)	1610	114798-26-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: losartan allisartan lortaan losartan potassium losartan monopotassium losartan monopotassium salt	An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II. Molecular weight: 422.92 Formula: C22H23ClN6O CLOGP: 3.85 LIPINSKI: 0 HAC: 7 HDO: 2 TPSA: 92.51 ALOGS: -4.97 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

losartan
allisartan
lortaan
losartan potassium
losartan monopotassium
losartan monopotassium salt

An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.

Molecular weight: 422.92
Formula: C22H23ClN6O
CLOGP: 3.85
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 92.51
ALOGS: -4.97
ROTB: 8

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
50	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.05 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	12 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	3.95 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	35 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.37 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	8.20 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1.80 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
April 14, 1995	FDA	MERCK SHARP DOHME

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	390.07	9.75	3	145817	157209	55989038
Rheumatoid arthritis	366.60	9.75	274	145546	382330	55763917
Synovitis	320.17	9.75	26	145794	161279	55984968
Systemic lupus erythematosus	305.41	9.75	50	145770	180028	55966219
Hand deformity	303.28	9.75	10	145810	134482	56011765
Maternal exposure during pregnancy	271.95	9.75	77	145743	189476	55956771
Contraindicated product administered	257.56	9.75	81	145739	186205	55960042
Glossodynia	235.89	9.75	53	145767	152405	55993842
Pericarditis	220.48	9.75	16	145804	108907	56037340
Drug ineffective	206.76	9.75	1466	144354	917523	55228724
Wound	205.41	9.75	53	145767	138751	56007496
Treatment failure	199.34	9.75	96	145724	170296	55975951
Infusion related reaction	199.27	9.75	150	145670	208781	55937466
Drug intolerance	198.87	9.75	236	145584	264582	55881665
Cardiac failure congestive	185.55	9.75	574	145246	87146	56059101
Arthropathy	165.21	9.75	165	145655	200110	55946137
Blood pressure increased	163.47	9.75	777	145043	144399	56001848
Duodenal ulcer perforation	161.91	9.75	3	145817	68339	56077908
Rheumatoid factor positive	159.80	9.75	4	145816	69056	56077191
Hepatic enzyme increased	146.20	9.75	137	145683	171247	55975000
Off label use	146.10	9.75	845	144975	555335	55590912
Dizziness	146.00	9.75	1552	144268	374588	55771659
Therapeutic product effect decreased	133.64	9.75	145	145675	169307	55976940
Helicobacter infection	127.17	9.75	19	145801	73249	56072998
Acute kidney injury	127.08	9.75	1061	144759	239702	55906545
Discomfort	126.06	9.75	109	145711	141652	56004595
Exposure during pregnancy	123.48	9.75	103	145717	136239	56010008
Folliculitis	120.74	9.75	5	145815	54974	56091273
Lower respiratory tract infection	117.85	9.75	76	145744	114718	56031529
Joint swelling	116.61	9.75	374	145446	289426	55856821
Swelling	111.38	9.75	289	145531	239482	55906765
Drug abuse	103.52	9.75	24	145796	67586	56078661
Hyponatraemia	100.95	9.75	527	145293	101612	56044635
Product substitution issue	98.71	9.75	153	145667	14446	56131801
Muscle injury	97.39	9.75	11	145809	52489	56093758
Cough	97.11	9.75	1065	144755	258896	55887351
Hypertension	96.94	9.75	1013	144807	243265	55902982
Diarrhoea	94.54	9.75	2240	143580	636267	55509980
Sleep disorder due to general medical condition, insomnia type	88.73	9.75	6	145814	43332	56102915
Product dose omission issue	88.37	9.75	864	144956	203889	55942358
Myocardial infarction	86.19	9.75	471	145349	92399	56053848
Blood glucose increased	81.44	9.75	398	145422	74753	56071494
Muscle spasms	80.88	9.75	621	145199	136750	56009497
Blood pressure inadequately controlled	79.69	9.75	77	145743	4447	56141800
Product use issue	76.22	9.75	238	145582	185803	55960444
Cerebrovascular accident	73.19	9.75	474	145346	98796	56047451
Feeling abnormal	72.63	9.75	593	145227	133009	56013238
Hyperkalaemia	72.21	9.75	292	145528	50573	56095674
Atrial fibrillation	71.34	9.75	505	145315	108392	56037855
Hypersensitivity	71.17	9.75	382	145438	256026	55890221
Malaise	64.51	9.75	1323	144497	366537	55779710
General physical health deterioration	63.78	9.75	226	145594	169784	55976463
Loss of employment	63.17	9.75	47	145773	1890	56144357
Irritable bowel syndrome	62.83	9.75	51	145769	68407	56077840
Febrile neutropenia	61.54	9.75	112	145708	105433	56040814
Toxicity to various agents	60.95	9.75	337	145483	224227	55922020
Abortion spontaneous	58.68	9.75	20	145800	43733	56102514
C-reactive protein increased	58.01	9.75	71	145749	78613	56067634
Pain	57.57	9.75	1295	144525	661889	55484358
Acute myocardial infarction	57.05	9.75	191	145629	30202	56116045
Infection	56.79	9.75	296	145524	199910	55946337
Coronary artery disease	56.45	9.75	192	145628	30604	56115643
Impaired healing	56.33	9.75	86	145734	86755	56059492
Pyrexia	56.17	9.75	756	145064	418017	55728230
Fall	55.04	9.75	1262	144558	356248	55789999
Palpitations	55.01	9.75	444	145376	99228	56047019
Chronic kidney disease	53.13	9.75	233	145587	41823	56104424
COVID-19	52.64	9.75	354	145466	74704	56071543
Hypertensive crisis	50.39	9.75	112	145708	13924	56132323
Alopecia	50.10	9.75	502	145318	292956	55853291
Pregnancy	50.02	9.75	12	145808	33021	56113226
Oligohydramnios	47.97	9.75	68	145752	5926	56140321
Asthenia	47.70	9.75	1194	144626	341779	55804468
Product taste abnormal	46.87	9.75	39	145781	1849	56144398
Myalgia	45.62	9.75	533	145287	131492	56014755
Chest pain	45.35	9.75	717	145103	189080	55957167
Dyspnoea	44.74	9.75	1918	143902	590659	55555588
Bradycardia	44.74	9.75	314	145506	67190	56079057
Abdominal discomfort	44.59	9.75	481	145339	276793	55869454
Intestinal angioedema	44.53	9.75	25	145795	614	56145633
Lactic acidosis	44.02	9.75	195	145625	35151	56111096
Blister	43.37	9.75	141	145679	108746	56037501
Body height decreased	43.27	9.75	82	145738	9103	56137144
Renal failure	43.15	9.75	457	145363	110043	56036204
Vision blurred	41.78	9.75	362	145458	82581	56063666
Blood pressure abnormal	41.39	9.75	102	145718	13558	56132689
Product odour abnormal	40.64	9.75	29	145791	1092	56145155
Therapy cessation	39.87	9.75	158	145662	27106	56119141
Cardiac disorder	38.76	9.75	227	145593	45660	56100587
Skin discolouration	38.67	9.75	184	145636	34172	56112075
Blood creatinine increased	38.33	9.75	346	145474	79845	56066402
Memory impairment	38.12	9.75	367	145453	86190	56060057
Glycosylated haemoglobin increased	37.75	9.75	87	145733	11078	56135169
Pancytopenia	37.36	9.75	112	145708	88603	56057644
Hip arthroplasty	36.41	9.75	28	145792	38595	56107652
Gastrointestinal disorder	36.39	9.75	159	145661	112543	56033704
Musculoskeletal stiffness	36.10	9.75	246	145574	155761	55990486
Oedema peripheral	34.36	9.75	629	145191	170625	55975622
Device expulsion	34.29	9.75	18	145802	30431	56115816
Live birth	34.20	9.75	5	145815	19600	56126647
Malignant mediastinal neoplasm	34.17	9.75	24	145796	881	56145366
Transient ischaemic attack	33.66	9.75	174	145646	33403	56112844
Neutropenia	33.41	9.75	256	145564	157911	55988336
Renal impairment	33.01	9.75	337	145483	80376	56065871
Dry skin	32.91	9.75	222	145598	46887	56099360
Full blood count decreased	32.30	9.75	133	145687	23216	56123031
Anti-neutrophil cytoplasmic antibody positive vasculitis	31.27	9.75	36	145784	2547	56143700
Asthmatic crisis	29.92	9.75	29	145791	1681	56144566
Loss of personal independence in daily activities	29.28	9.75	110	145710	81259	56064988
Inappropriate antidiuretic hormone secretion	29.03	9.75	90	145730	13666	56132581
Suicide attempt	28.93	9.75	67	145753	57769	56088478
Urinary tract infection	28.70	9.75	821	144999	239692	55906555
Dysgeusia	28.69	9.75	193	145627	40722	56105525
Hypoglycaemia	28.31	9.75	244	145576	55571	56090676
Psoriasis	28.03	9.75	365	145455	92327	56053920
Flatulence	27.88	9.75	157	145663	31131	56115116
Therapeutic product effect incomplete	27.71	9.75	161	145659	105870	56040377
Condition aggravated	27.69	9.75	681	145139	344217	55802030
Liver injury	27.56	9.75	41	145779	41807	56104440
Fibromyalgia	27.49	9.75	72	145748	59531	56086716
CD30 expression	27.28	9.75	8	145812	30	56146217
Leukopenia	26.78	9.75	94	145726	70846	56075401
Mobility decreased	26.58	9.75	149	145671	98842	56047405
Ill-defined disorder	26.43	9.75	90	145730	68453	56077794
Mitral valve incompetence	26.38	9.75	105	145715	18048	56128199
Glomerulonephritis rapidly progressive	26.12	9.75	20	145800	840	56145407
Abdominal pain upper	25.69	9.75	624	145196	177689	55968558
Pulmonary oedema	25.63	9.75	223	145597	50920	56095327
Renal disorder	24.71	9.75	146	145674	29459	56116788
Dysphonia	24.30	9.75	189	145631	41758	56104489
Neuropathy peripheral	24.28	9.75	388	145432	102505	56043742
Malignant neoplasm progression	24.25	9.75	103	145717	73484	56072763
Hypotension	24.06	9.75	833	144987	249675	55896572
Bone erosion	23.55	9.75	5	145815	14969	56131278
Syncope	23.32	9.75	402	145418	107797	56038450
Bundle branch block left	23.10	9.75	51	145769	6311	56139936
Eye irritation	22.95	9.75	104	145716	18924	56127323
Gastrointestinal haemorrhage	22.92	9.75	299	145521	75652	56070595
Cutaneous T-cell dyscrasia	22.48	9.75	8	145812	62	56146185
Drug tolerance decreased	22.10	9.75	4	145816	13407	56132840
Hypoparathyroidism	21.93	9.75	16	145804	624	56145623
Blood potassium decreased	21.72	9.75	173	145647	38499	56107748
Hepatic steatosis	21.70	9.75	129	145691	26085	56120162
Overweight	21.38	9.75	34	145786	3280	56142967
Papillary muscle rupture	21.34	9.75	5	145815	5	56146242
Intentional self-injury	21.25	9.75	20	145800	24972	56121275
Sprue-like enteropathy	21.25	9.75	15	145805	555	56145692
Intentional product use issue	21.24	9.75	161	145659	99572	56046675
Diabetes mellitus inadequate control	21.24	9.75	82	145738	13898	56132349
Body temperature increased	21.16	9.75	35	145785	34207	56112040
Angioedema	20.90	9.75	181	145639	41272	56104975
Vitamin B6 deficiency	20.78	9.75	8	145812	79	56146168
Milk-alkali syndrome	20.69	9.75	16	145804	682	56145565
Product quality issue	20.66	9.75	147	145673	31589	56114658
Balance disorder	20.54	9.75	295	145525	76225	56070022
Red blood cell sedimentation rate increased	20.34	9.75	40	145780	36583	56109664
Hyperglycaemia	20.28	9.75	169	145651	38112	56108135
Noninfectious peritonitis	20.14	9.75	9	145811	133	56146114
Glomerular filtration rate decreased	20.13	9.75	74	145746	12255	56133992
Primary hyperaldosteronism	20.04	9.75	7	145813	51	56146196
Cardiac failure	19.53	9.75	310	145510	81783	56064464
Cytomegalovirus infection	19.48	9.75	13	145807	19283	56126964
Influenza	19.48	9.75	351	145469	94910	56051337
Dehydration	19.44	9.75	544	145276	158281	55987966
Suspected suicide	18.93	9.75	43	145777	5423	56140824
Blood urea increased	18.72	9.75	118	145702	24355	56121892
Myelosuppression	18.67	9.75	11	145809	17444	56128803
Blood phosphorus increased	18.63	9.75	29	145791	2747	56143500
Multi-organ disorder	18.58	9.75	20	145800	1313	56144934
Sedation	18.56	9.75	39	145781	34815	56111432
Vascular stenosis	18.43	9.75	11	145809	304	56145943
Diabetic ketoacidosis	18.36	9.75	97	145723	18774	56127473
Near death experience	18.16	9.75	12	145808	398	56145849
Nervousness	18.08	9.75	133	145687	28882	56117365
Ageusia	18.08	9.75	72	145748	12379	56133868
Product residue present	18.02	9.75	34	145786	3761	56142486
Myeloma cast nephropathy	17.98	9.75	8	145812	117	56146130
Blood pressure diastolic abnormal	17.98	9.75	4	145816	11594	56134653
Thrombosis	17.95	9.75	234	145586	59193	56087054
Sialoadenitis	17.89	9.75	21	145799	1517	56144730
Injection site reaction	17.87	9.75	74	145746	53173	56093074
Blood glucose decreased	17.82	9.75	97	145723	18990	56127257
Swollen tongue	17.77	9.75	137	145683	30187	56116060
Sodium retention	17.68	9.75	8	145812	122	56146125
Hypomagnesaemia	17.54	9.75	118	145702	24897	56121350
Bone marrow failure	17.40	9.75	29	145791	28257	56117990
Atrioventricular block	17.35	9.75	48	145772	6839	56139408
Linear IgA disease	17.33	9.75	19	145801	1274	56144973
Injury	17.22	9.75	88	145732	59763	56086484
Eye haemorrhage	17.17	9.75	52	145768	7795	56138452
Drug interaction	17.11	9.75	685	145135	209070	55937177
Anuria	17.07	9.75	68	145752	11692	56134555
Nodular rash	17.00	9.75	9	145811	196	56146051
Coma	17.00	9.75	88	145732	59567	56086680
Diabetic foot	16.92	9.75	19	145801	1308	56144939
Hyperlipidaemia	16.88	9.75	92	145728	18017	56128230
Eye pain	16.78	9.75	137	145683	30710	56115537
Premature baby	16.77	9.75	15	145805	19190	56127057
Catarrh	16.72	9.75	11	145809	362	56145885
Venous occlusion	16.67	9.75	15	145805	791	56145456
Nausea	16.67	9.75	2240	143580	761938	55384309
Arrhythmia	16.56	9.75	151	145669	34932	56111315
Thymus disorder	16.48	9.75	10	145810	285	56145962
Ischaemic cardiomyopathy	16.37	9.75	25	145795	2329	56143918
Pseudolymphoma	16.32	9.75	13	145807	579	56145668
Foetal exposure during pregnancy	16.26	9.75	40	145780	33783	56112464
Nasal congestion	16.21	9.75	220	145600	56150	56090097
Gait disturbance	16.14	9.75	545	145275	162776	55983471
Panniculitis	16.08	9.75	3	145817	9839	56136408
Blood pressure systolic abnormal	15.93	9.75	3	145817	9774	56136473
Neuroleptic malignant syndrome	15.82	9.75	5	145815	11473	56134774
Knee arthroplasty	15.81	9.75	60	145760	44199	56102048
Muscle spasticity	15.80	9.75	17	145803	19943	56126304
International normalised ratio increased	15.73	9.75	179	145641	43862	56102385
Gout	15.65	9.75	68	145752	12153	56134094
Lacrimation increased	15.64	9.75	91	145729	18257	56127990
Oral pain	15.52	9.75	119	145701	26174	56120073
Tremor	15.45	9.75	417	145403	120672	56025575
Disability	15.44	9.75	11	145809	15769	56130478
Norepinephrine increased	15.26	9.75	6	145814	63	56146184
Diabetes mellitus	15.24	9.75	206	145614	52529	56093718
Therapy interrupted	15.14	9.75	116	145704	25509	56120738
Insomnia	15.05	9.75	624	145196	191236	55955011
Mouth swelling	15.05	9.75	33	145787	4064	56142183
Haemoglobin decreased	14.92	9.75	454	145366	133683	56012564
Eosinophilia myalgia syndrome	14.85	9.75	4	145816	10	56146237
Angina unstable	14.74	9.75	45	145775	6776	56139471
Sinus bradycardia	14.74	9.75	72	145748	13514	56132733
Gastritis	14.71	9.75	146	145674	34556	56111691
Premature delivery	14.64	9.75	30	145790	27030	56119217
Type 2 diabetes mellitus	14.58	9.75	67	145753	46795	56099452
Decreased appetite	14.57	9.75	701	145119	218530	55927717
Angina pectoris	14.55	9.75	123	145697	27853	56118394
Electrocardiogram PR prolongation	14.53	9.75	13	145807	680	56145567
Thyroid disorder	14.50	9.75	73	145747	13865	56132382
Blood pressure decreased	14.43	9.75	224	145596	58826	56087421
Urine albumin/creatinine ratio increased	14.42	9.75	9	145811	270	56145977
Diabetic retinopathy	14.41	9.75	23	145797	2226	56144021
Weight decreased	14.41	9.75	762	145058	239952	55906295
Headache	14.40	9.75	1656	144164	557388	55588859
Pruritus	14.38	9.75	978	144842	315645	55830602
Blood immunoglobulin E increased	14.34	9.75	27	145793	2982	56143265
Arrhythmia supraventricular	14.33	9.75	15	145805	954	56145293
Hepatic failure	14.29	9.75	42	145778	33444	56112803
Patella fracture	14.18	9.75	21	145799	1904	56144343
Recalled product administered	14.14	9.75	11	145809	473	56145774
Amenorrhoea	14.13	9.75	3	145817	8983	56137264
Hepatotoxicity	14.09	9.75	38	145782	31115	56115132
Extradural haematoma	14.08	9.75	19	145801	1581	56144666
Ascites	14.00	9.75	50	145770	37494	56108753
Acute myeloid leukaemia	13.95	9.75	14	145806	16958	56129289
Pain in extremity	13.91	9.75	921	144899	296510	55849737
Cholecystitis chronic	13.88	9.75	4	145816	9744	56136503
Suicidal ideation	13.87	9.75	90	145730	57652	56088595
Otolithiasis	13.85	9.75	4	145816	14	56146233
Choking	13.85	9.75	53	145767	8944	56137303
Generalised tonic-clonic seizure	13.73	9.75	32	145788	27534	56118713
Blood sodium decreased	13.70	9.75	102	145718	22232	56124015
Blood magnesium decreased	13.66	9.75	64	145756	11810	56134437
Dengue fever	13.66	9.75	12	145808	613	56145634
Blood pressure diastolic decreased	13.65	9.75	18	145802	19305	56126942
Drug resistance	13.65	9.75	20	145800	20522	56125725
Anaphylactic reaction	13.64	9.75	93	145727	58902	56087345
Epilepsy	13.63	9.75	28	145792	25203	56121044
Eyelid pain	13.55	9.75	9	145811	301	56145946
Upper gastrointestinal haemorrhage	13.53	9.75	83	145737	16971	56129276
Rhinorrhoea	13.42	9.75	215	145605	56822	56089425
Haemorrhage intracranial	13.41	9.75	67	145753	12688	56133559
Anosmia	13.39	9.75	33	145787	4386	56141861
Crystal urine	13.21	9.75	5	145815	47	56146200
Spinal epidural haematoma	13.14	9.75	15	145805	1052	56145195
Product dispensing error	12.99	9.75	53	145767	9211	56137036
Haemorrhagic stroke	12.97	9.75	37	145783	5366	56140881
Drug hypersensitivity	12.89	9.75	582	145238	274623	55871624
Cardiorenal syndrome	12.68	9.75	13	145807	807	56145440
Renin decreased	12.67	9.75	6	145814	102	56146145
Platelet count decreased	12.62	9.75	363	145457	106020	56040227
Product physical issue	12.62	9.75	33	145787	4549	56141698
Blindness transient	12.59	9.75	28	145792	3482	56142765
Poor quality product administered	12.58	9.75	25	145795	2874	56143373
Hypoacusis	12.56	9.75	98	145722	21670	56124577
Nasopharyngitis	12.55	9.75	457	145363	220502	55925745
Aortic stenosis	12.53	9.75	32	145788	4348	56141899
Head injury	12.40	9.75	109	145711	24957	56121290
Cardiac valve disease	12.35	9.75	30	145790	3951	56142296
Leukaemoid reaction	12.32	9.75	7	145813	176	56146071
Swelling face	12.32	9.75	209	145611	55860	56090387
Back pain	12.29	9.75	741	145079	236429	55909818
Hiccups	12.29	9.75	20	145800	1968	56144279
Hypertensive encephalopathy	12.22	9.75	11	145809	580	56145667
Agitation	12.15	9.75	90	145730	55946	56090301
Chikungunya virus infection	12.15	9.75	7	145813	181	56146066
Schizophrenia	12.13	9.75	6	145814	10493	56135754
Instillation site pain	12.12	9.75	13	145807	850	56145397
Product packaging issue	12.07	9.75	14	145806	999	56145248
Cardiovascular disorder	12.02	9.75	58	145762	10831	56135416
Laboratory test abnormal	12.02	9.75	107	145713	24588	56121659
Premature labour	12.00	9.75	8	145812	11874	56134373
Gastroenteritis aeromonas	11.98	9.75	4	145816	25	56146222
Nail bed tenderness	11.92	9.75	9	145811	370	56145877
Gastric disorder	11.87	9.75	135	145685	33075	56113172
Rash	11.84	9.75	1108	144712	491939	55654308
Left ventricular hypertrophy	11.84	9.75	34	145786	4950	56141297
Human herpesvirus 6 encephalitis	11.81	9.75	7	145813	191	56146056
Haemophagocytic lymphohistiocytosis	11.79	9.75	5	145815	9567	56136680
Dystonia	11.71	9.75	9	145811	12412	56133835
Pulmonary toxicity	11.67	9.75	3	145817	7880	56138367
Septic shock	11.67	9.75	101	145719	60734	56085513
Taste disorder	11.64	9.75	53	145767	9662	56136585
Familial periodic paralysis	11.63	9.75	5	145815	67	56146180
Sedation complication	11.60	9.75	8	145812	11664	56134583
Haemorrhagic fever	11.60	9.75	3	145817	6	56146241
Diabetic metabolic decompensation	11.57	9.75	17	145803	1531	56144716
Fear	11.47	9.75	72	145748	14836	56131411
Renal hypertrophy	11.47	9.75	4	145816	29	56146218
Atrial septal defect	11.43	9.75	40	145780	6466	56139781
Overdose	11.41	9.75	199	145621	105631	56040616
Blindness unilateral	11.38	9.75	36	145784	5524	56140723
Visual impairment	11.38	9.75	262	145558	73940	56072307
Affect lability	11.38	9.75	6	145814	10119	56136128
Drug dependence	11.35	9.75	26	145794	22507	56123740
Carotid bruit	11.32	9.75	11	145809	640	56145607
Stomatitis	11.24	9.75	233	145587	120577	56025670
Eructation	11.11	9.75	44	145776	7544	56138703
End stage renal disease	11.11	9.75	38	145782	6073	56140174
Drug monitoring procedure not performed	11.04	9.75	10	145810	532	56145715
Transplant rejection	11.00	9.75	6	145814	9928	56136319
Ultrasound kidney abnormal	10.92	9.75	4	145816	34	56146213
Arteriosclerosis	10.91	9.75	51	145769	9402	56136845
Pneumonia aspiration	10.90	9.75	45	145775	32366	56113881
Creatinine renal clearance decreased	10.87	9.75	13	145807	14546	56131701
Hypovolaemia	10.85	9.75	52	145768	9683	56136564
Chronic obstructive pulmonary disease	10.85	9.75	209	145611	57206	56089041
Renal artery stenosis	10.81	9.75	18	145802	1805	56144442
Migraine	10.76	9.75	159	145661	86638	56059609
Normal newborn	10.76	9.75	3	145817	7467	56138780
Periorbital oedema	10.74	9.75	34	145786	5220	56141027
Bronchopulmonary aspergillosis	10.70	9.75	4	145816	8260	56137987
Device dislocation	10.66	9.75	27	145793	22579	56123668
Mucosal inflammation	10.65	9.75	66	145754	42744	56103503
Faeces discoloured	10.64	9.75	78	145742	16918	56129329
Intentional overdose	10.59	9.75	119	145701	67998	56078249
Chromaturia	10.57	9.75	72	145748	15253	56130994
Atrioventricular block first degree	10.54	9.75	40	145780	6725	56139522
Dry eye	10.52	9.75	140	145680	35576	56110671
Dermatitis atopic	10.49	9.75	46	145774	8253	56137994
Product supply issue	10.48	9.75	16	145804	1490	56144757
Onychoclasis	10.39	9.75	35	145785	5550	56140697
Heart valve calcification	10.28	9.75	3	145817	11	56146236
Carotid artery stenosis	10.25	9.75	32	145788	4878	56141369
Blood aldosterone increased	10.11	9.75	6	145814	164	56146083
Mania	10.06	9.75	9	145811	11511	56134736
Poisoning	10.04	9.75	11	145809	12802	56133445
Blood triglycerides increased	10.01	9.75	58	145762	11619	56134628
Respiratory arrest	10.00	9.75	43	145777	30582	56115665
Cardiomegaly	9.98	9.75	75	145745	16392	56129855
Generalised anxiety disorder	9.97	9.75	18	145802	1926	56144321
Myopathy	9.94	9.75	51	145769	9761	56136486
Bone pain	9.93	9.75	184	145636	50001	56096246
Device difficult to use	9.89	9.75	8	145812	10753	56135494
Nail infection	9.86	9.75	20	145800	2333	56143914
Unevaluable event	9.84	9.75	176	145644	47511	56098736
Thrombocytopenia	9.83	9.75	273	145547	135951	56010296
Status epilepticus	9.81	9.75	15	145805	15126	56131121
ADAMTS13 activity decreased	9.78	9.75	5	145815	101	56146146
Neonatal anuria	9.77	9.75	4	145816	47	56146200
Progressive multifocal leukoencephalopathy	9.77	9.75	10	145810	12003	56134244

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	166.27	10.50	27	91515	87731	31518071
Angioedema	123.53	10.50	289	91253	33329	31572473
Febrile neutropenia	100.95	10.50	122	91420	121727	31484075
Toxicity to various agents	94.78	10.50	243	91299	181244	31424558
Cardiac failure congestive	90.57	10.50	461	91081	78926	31526876
Dizziness	86.56	10.50	917	90625	198230	31407572
Neutropenia	85.36	10.50	173	91369	140191	31465611
Off label use	80.77	10.50	630	90912	346644	31259158
Foetal exposure during pregnancy	76.43	10.50	13	91529	40863	31564939
Hypertension	75.17	10.50	629	90913	127471	31478331
Myocardial infarction	68.10	10.50	560	90982	112894	31492908
Fatigue	65.49	10.50	1343	90199	333863	31271939
Acute myocardial infarction	62.81	10.50	302	91240	50521	31555281
Suicide attempt	55.67	10.50	19	91523	37229	31568573
Hyperkalaemia	55.03	10.50	346	91196	64005	31541797
Leukopenia	50.99	10.50	55	91487	57773	31548029
Product dose omission issue	49.46	10.50	494	91048	105092	31500710
Pyrexia	49.07	10.50	602	90940	303238	31302564
Sprue-like enteropathy	48.80	10.50	25	91517	453	31605349
Blood pressure increased	46.63	10.50	391	91151	79242	31526560
General physical health deterioration	45.56	10.50	171	91371	113264	31492538
Drug ineffective	45.56	10.50	837	90705	394736	31211066
Angina unstable	45.27	10.50	100	91442	11095	31594707
Product substitution issue	40.13	10.50	86	91456	9346	31596456
Serotonin syndrome	39.80	10.50	4	91538	18769	31587033
Thrombocytopenia	38.88	10.50	247	91295	142500	31463302
Myalgia	38.87	10.50	367	91175	76891	31528911
Peripheral swelling	37.50	10.50	329	91213	67536	31538266
Cerebrovascular accident	36.29	10.50	370	91172	79114	31526688
Cytomegalovirus infection	36.24	10.50	13	91529	24694	31581108
Atrial fibrillation	35.33	10.50	492	91050	113291	31492511
Blood glucose increased	35.26	10.50	299	91243	60784	31545018
Coronary artery disease	35.25	10.50	241	91301	45846	31559956
Overdose	35.05	10.50	126	91416	84538	31521264
Treatment failure	34.63	10.50	40	91502	40752	31565050
Intentional overdose	33.64	10.50	42	91500	41347	31564455
Plasmapheresis	33.38	10.50	17	91525	304	31605498
Coma	33.19	10.50	42	91500	41108	31564694
Cardiac disorder	32.98	10.50	210	91332	39004	31566798
Drug dispensed to wrong patient	32.16	10.50	19	91523	460	31605342
Paraesthesia	30.03	10.50	270	91272	55801	31550001
Hypertensive crisis	29.30	10.50	70	91472	8177	31597625
Diarrhoea	28.86	10.50	1268	90274	351141	31254661
Acute kidney injury	28.60	10.50	1031	90511	278683	31327119
Epilepsy	27.73	10.50	13	91529	21028	31584774
Intestinal angioedema	27.16	10.50	13	91529	202	31605600
Psoriasis	27.12	10.50	229	91313	46490	31559312
Multiple organ dysfunction syndrome	26.60	10.50	104	91438	68099	31537703
Pruritus	26.46	10.50	508	91034	124659	31481143
Septic shock	25.72	10.50	101	91441	66057	31539745
Malignant neoplasm progression	25.65	10.50	129	91413	78869	31526933
Feeling abnormal	25.36	10.50	264	91278	56738	31549064
Dyspnoea	25.32	10.50	1223	90319	342256	31263546
Mucosal inflammation	24.90	10.50	38	91504	34389	31571413
Palpitations	24.77	10.50	178	91364	34405	31571397
Neuroleptic malignant syndrome	24.53	10.50	9	91533	16860	31588942
Cough	24.49	10.50	535	91007	134279	31471523
Rheumatoid arthritis	23.39	10.50	66	91476	47743	31558059
Paraplegia	22.35	10.50	33	91509	2674	31603128
Pancytopenia	21.79	10.50	155	91387	87161	31518641
Blood pressure inadequately controlled	21.69	10.50	31	91511	2438	31603364
Skin discolouration	21.66	10.50	99	91443	16208	31589594
Syncope	21.64	10.50	356	91186	84826	31520976
Diabetic neuropathy	21.60	10.50	40	91502	3909	31601893
Transient ischaemic attack	21.58	10.50	131	91411	23925	31581877
Schizophrenia	21.25	10.50	3	91539	10827	31594975
Chronic kidney disease	20.91	10.50	184	91358	37791	31568011
Alanine aminotransferase increased	20.39	10.50	129	91413	74527	31531275
Rash	20.39	10.50	742	90800	200744	31405058
Abdominal discomfort	20.25	10.50	233	91309	51334	31554468
Status epilepticus	20.24	10.50	5	91537	12101	31593701
Neurotoxicity	19.93	10.50	11	91531	16215	31589587
Premature baby	19.77	10.50	14	91528	18052	31587750
Condition aggravated	19.72	10.50	344	91198	163665	31442137
Infusion related reaction	19.56	10.50	72	91470	47983	31557819
Abdominal wall haematoma	19.14	10.50	24	91518	1663	31604139
Hyperthermia	19.10	10.50	3	91539	10001	31595801
C-reactive protein increased	19.08	10.50	74	91468	48576	31557226
Hepatic cytolysis	19.04	10.50	4	91538	10819	31594983
Carcinogenicity	18.52	10.50	7	91535	58	31605744
Delirium	18.24	10.50	60	91482	41361	31564441
Hypertensive emergency	18.16	10.50	18	91524	960	31604842
Gastroenteritis eosinophilic	18.03	10.50	9	91533	154	31605648
Cholestasis	17.82	10.50	28	91514	25047	31580755
Guillain-Barre syndrome	17.45	10.50	44	91498	5316	31600486
Bone marrow failure	17.43	10.50	34	91508	27974	31577828
Disease progression	17.40	10.50	172	91370	90292	31515510
Vitamin B1 deficiency	17.30	10.50	11	91531	305	31605497
High frequency ablation	17.23	10.50	9	91533	170	31605632
Drug dependence	17.23	10.50	24	91518	22555	31583247
Contraindicated product administered	17.20	10.50	19	91523	19753	31586049
Gamma-glutamyltransferase increased	17.13	10.50	34	91508	27791	31578011
Balance disorder	16.96	10.50	174	91368	37248	31568554
Asthenia	16.87	10.50	802	90740	223953	31381849
Blood pressure abnormal	16.65	10.50	53	91489	7316	31598486
Vascular injury	16.36	10.50	10	91532	258	31605544
Intentional product use issue	16.34	10.50	80	91462	49267	31556535
Ascites	16.33	10.50	62	91480	40951	31564851
Respiratory depression	16.20	10.50	11	91531	14499	31591303
Acute respiratory distress syndrome	15.97	10.50	29	91513	24511	31581291
Pathogen resistance	15.76	10.50	3	91539	8698	31597104
Product use in unapproved indication	15.73	10.50	197	91345	98974	31506828
Antineutrophil cytoplasmic antibody increased	15.70	10.50	5	91537	23	31605779
Blood creatinine increased	15.68	10.50	352	91190	88726	31517076
Sedation	15.66	10.50	19	91523	18946	31586856
Diffuse large B-cell lymphoma	15.60	10.50	3	91539	8638	31597164
Posterior reversible encephalopathy syndrome	15.41	10.50	4	91538	9363	31596439
COVID-19	15.39	10.50	233	91309	54588	31551214
Pneumocystis jirovecii pneumonia	15.38	10.50	18	91524	18233	31587569
Cardiac flutter	15.30	10.50	22	91520	1740	31604062
Diabetic foot	15.27	10.50	26	91516	2379	31603423
Hyponatraemic seizure	15.16	10.50	6	91536	57	31605745
Fluid retention	15.15	10.50	123	91419	24679	31581123
Ageusia	14.98	10.50	60	91482	9271	31596531
Burning feet syndrome	14.97	10.50	7	91535	103	31605699
Tubulointerstitial nephritis	14.90	10.50	98	91444	18398	31587404
Atheroembolism	14.80	10.50	9	91533	230	31605572
Pneumonia aspiration	14.49	10.50	60	91482	38666	31567136
Cytokine release syndrome	14.47	10.50	16	91526	16626	31589176
Oral mucosal blistering	14.38	10.50	21	91521	1684	31604118
Therapeutic product effect incomplete	14.38	10.50	71	91471	43625	31562177
Chikungunya virus infection	14.21	10.50	5	91537	33	31605769
Muscular weakness	13.93	10.50	266	91276	65182	31540620
Eczema nummular	13.91	10.50	7	91535	122	31605680
Renal disorder	13.77	10.50	116	91426	23529	31582273
Depressed level of consciousness	13.71	10.50	61	91481	38540	31567262
Muscle spasms	13.65	10.50	275	91267	68043	31537759
Heat stroke	13.63	10.50	15	91527	904	31604898
Shoshin beriberi	13.63	10.50	6	91536	76	31605726
Febrile bone marrow aplasia	13.60	10.50	3	91539	7843	31597959
Tinnitus	13.58	10.50	87	91455	16188	31589614
Product quality issue	13.37	10.50	86	91456	16025	31589777
Tenosynovitis stenosans	13.21	10.50	4	91538	15	31605787
Blood glucose decreased	13.21	10.50	71	91471	12400	31593402
Back pain	13.09	10.50	411	91131	109002	31496800
Dysphonia	13.06	10.50	103	91439	20488	31585314
Aspartate aminotransferase increased	13.02	10.50	117	91425	62602	31543200
Product odour abnormal	13.01	10.50	13	91529	700	31605102
Eosinophilia	12.99	10.50	30	91512	23223	31582579
Coeliac disease	12.89	10.50	12	91530	592	31605210
Recalled product administered	12.86	10.50	11	91531	485	31605317
Eye infection	12.85	10.50	28	91514	3077	31602725
Skin exfoliation	12.79	10.50	115	91427	23759	31582043
Renal pain	12.73	10.50	27	91515	2912	31602890
Flatulence	12.69	10.50	96	91446	18852	31586950
Hepatocellular injury	12.69	10.50	27	91515	21517	31584285
Aggression	12.61	10.50	60	91482	37231	31568571
Generalised tonic-clonic seizure	12.57	10.50	24	91518	19907	31585895
Application site haematoma	12.49	10.50	5	91537	49	31605753
B-cell small lymphocytic lymphoma stage IV	12.48	10.50	3	91539	3	31605799
Cataract	12.41	10.50	114	91428	23693	31582109
Tendon rupture	12.18	10.50	44	91498	6475	31599327
Anhidrosis	12.16	10.50	6	91536	100	31605702
Lichen planus	12.14	10.50	14	91528	889	31604913
Coordination abnormal	11.94	10.50	47	91495	7204	31598598
Toxic epidermal necrolysis	11.89	10.50	24	91518	19500	31586302
Haematotoxicity	11.83	10.50	3	91539	7134	31598668
Exposure during pregnancy	11.82	10.50	5	91537	8593	31597209
Miosis	11.76	10.50	5	91537	8565	31597237
Glomerular filtration rate decreased	11.53	10.50	66	91476	11799	31594003
Poisoning	11.44	10.50	8	91534	10383	31595419
Carotid bruit	11.34	10.50	7	91535	184	31605618
Extremity necrosis	11.27	10.50	19	91523	1724	31604078
Bradyarrhythmia	11.21	10.50	21	91521	2070	31603732
Seizure	11.12	10.50	212	91330	99556	31506246
Dysgeusia	11.06	10.50	110	91432	23356	31582446
Gout	11.03	10.50	90	91452	18084	31587718
Weight decreased	10.99	10.50	566	90976	159386	31446416
Constipation	10.95	10.50	450	91092	123541	31482261
Osteoarthritis	10.81	10.50	93	91449	18974	31586828
Blister	10.79	10.50	100	91442	20836	31584966
Dry mouth	10.74	10.50	113	91429	24345	31581457
Psychotic disorder	10.73	10.50	31	91511	22262	31583540
Aortic dissection	10.73	10.50	23	91519	2499	31603303
Cachexia	10.71	10.50	3	91539	6676	31599126
Deafness bilateral	10.63	10.50	14	91528	1019	31604783
Dengue fever	10.61	10.50	7	91535	207	31605595

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure congestive	262.30	9.49	877	188466	134580	70604521
Drug abuse	246.59	9.49	47	189296	147209	70591892
Synovitis	237.15	9.49	32	189311	129196	70609905
Rheumatoid arthritis	228.94	9.49	265	189078	291540	70447561
Maternal exposure during pregnancy	192.71	9.49	37	189306	115308	70623793
Off label use	190.86	9.49	1183	188160	741877	69997224
Hand deformity	189.60	9.49	10	189333	86472	70652629
Drug ineffective	185.42	9.49	1613	187730	938139	69800962
Pemphigus	169.11	9.49	14	189329	83022	70656079
Infusion related reaction	161.84	9.49	173	189170	197361	70541740
Myocardial infarction	160.24	9.49	891	188452	170754	70568347
Contraindicated product administered	159.37	9.49	80	189263	134532	70604569
Dizziness	147.79	9.49	1889	187454	462252	70276849
Acute kidney injury	141.23	9.49	1908	187435	472716	70266385
Systemic lupus erythematosus	139.17	9.49	49	189294	101853	70637248
Febrile neutropenia	134.33	9.49	211	189132	204107	70534994
Angioedema	132.14	9.49	435	188908	66175	70672926
Hypertension	129.15	9.49	1282	188061	294751	70444350
Treatment failure	127.50	9.49	118	189225	144024	70595077
Blood pressure increased	127.43	9.49	901	188442	187616	70551485
Toxicity to various agents	126.08	9.49	558	188785	381614	70357487
Drug intolerance	115.25	9.49	271	189072	225416	70513685
Rheumatoid factor positive	114.96	9.49	3	189340	48397	70690704
Duodenal ulcer perforation	111.74	9.49	6	189337	51106	70687995
Cerebrovascular accident	110.91	9.49	709	188634	142761	70596340
Hepatic enzyme increased	110.10	9.49	155	189188	156835	70582266
Pericarditis	108.56	9.49	45	189298	84660	70654441
Acute myocardial infarction	106.50	9.49	431	188912	72456	70666645
Hyperkalaemia	104.57	9.49	561	188782	106030	70633071
Atrial fibrillation	101.57	9.49	840	188503	183508	70555593
Product dose omission issue	99.28	9.49	951	188392	216517	70522584
Folliculitis	96.29	9.49	4	189339	42566	70696535
Wound	94.40	9.49	75	189268	98657	70640444
Blood glucose increased	94.31	9.49	532	188811	102450	70636651
General physical health deterioration	91.50	9.49	323	189020	235708	70503393
Glossodynia	90.10	9.49	60	189283	86427	70652674
Coronary artery disease	90.08	9.49	369	188974	62367	70676734
C-reactive protein abnormal	89.41	9.49	3	189340	38576	70700525
Helicobacter infection	88.51	9.49	20	189323	55636	70683465
Neutropenia	88.06	9.49	370	188973	256786	70482315
Pyrexia	84.04	9.49	1129	188214	605823	70133278
Hyponatraemia	82.64	9.49	719	188624	159368	70579733
Product substitution issue	80.98	9.49	163	189180	18350	70720751
Exposure during pregnancy	80.92	9.49	69	189274	87648	70651453
Arthropathy	79.14	9.49	177	189166	149880	70589221
Lower respiratory tract infection	76.96	9.49	112	189231	111801	70627300
Sleep disorder due to general medical condition, insomnia type	75.67	9.49	5	189338	35727	70703374
Therapeutic product effect decreased	75.18	9.49	169	189174	142849	70596252
Intestinal angioedema	71.28	9.49	38	189305	814	70738287
Cough	70.03	9.49	1239	188104	324138	70414963
Joint swelling	69.49	9.49	394	188949	252817	70486284
Diarrhoea	68.92	9.49	2647	186696	780694	69958407
Cardiac disorder	67.55	9.49	326	189017	59089	70680012
Sprue-like enteropathy	67.07	9.49	40	189303	1070	70738031
Myalgia	65.93	9.49	712	188631	167180	70571921
Feeling abnormal	64.22	9.49	621	188722	141698	70597403
Muscle injury	62.90	9.49	13	189330	38481	70700620
Hypertensive crisis	62.04	9.49	150	189193	19112	70719989
C-reactive protein increased	61.90	9.49	126	189217	110391	70628710
Discomfort	59.23	9.49	120	189223	105316	70633785
Palpitations	56.38	9.49	496	188847	110257	70628844
Loss of employment	55.54	9.49	47	189296	2212	70736889
Dyspnoea	55.39	9.49	2548	186795	767512	69971589
Leukopenia	54.31	9.49	128	189215	106432	70632669
Suicide attempt	52.31	9.49	82	189261	79428	70659673
Infection	52.04	9.49	339	189004	210446	70528655
COVID-19	51.97	9.49	470	188873	105287	70633814
Blood creatinine increased	51.83	9.49	597	188746	142404	70596697
Blood pressure inadequately controlled	51.57	9.49	69	189274	5523	70733578
Pancytopenia	50.70	9.49	219	189124	150888	70588213
Body height decreased	50.00	9.49	81	189262	7702	70731399
Muscle spasms	49.25	9.49	628	188715	153418	70585683
Lactic acidosis	48.16	9.49	318	189025	64706	70674395
Irritable bowel syndrome	48.13	9.49	39	189304	50811	70688290
Cytomegalovirus infection	47.98	9.49	23	189320	39735	70699366
Chronic kidney disease	47.91	9.49	303	189040	60754	70678347
Asthenia	47.35	9.49	1576	187767	456090	70283011
Chest pain	46.17	9.49	934	188409	250326	70488775
Coma	45.47	9.49	112	189231	91732	70647369
Angina unstable	43.12	9.49	116	189227	15777	70723324
Syncope	41.48	9.49	647	188696	165062	70574039
Swelling	40.31	9.49	316	189027	188223	70550878
Transient ischaemic attack	39.20	9.49	233	189110	45711	70693390
Malaise	39.10	9.49	1468	187875	431464	70307637
Drug resistance	39.09	9.49	27	189316	38163	70700938
Neuroleptic malignant syndrome	38.17	9.49	11	189332	25996	70713105
Drug dispensed to wrong patient	38.01	9.49	22	189321	556	70738545
Therapy cessation	37.71	9.49	184	189159	33492	70705609
Skin discolouration	37.63	9.49	198	189145	37127	70701974
Fall	37.53	9.49	1495	187848	442601	70296500
Pregnancy	36.91	9.49	9	189334	23772	70715329
Aspergillus infection	36.41	9.49	3	189340	17865	70721236
Malignant neoplasm progression	36.37	9.49	184	189159	121555	70617546
Fatigue	35.52	9.49	2605	186738	821714	69917387
Glomerular filtration rate decreased	35.44	9.49	129	189214	20627	70718474
Epilepsy	35.16	9.49	31	189312	38753	70700348
Intentional product use issue	34.53	9.49	184	189159	119958	70619143
Poisoning deliberate	34.39	9.49	3	189340	17057	70722044
Overdose	34.22	9.49	289	189054	169456	70569645
Product use issue	34.22	9.49	311	189032	179626	70559475
Product taste abnormal	34.21	9.49	35	189308	2101	70737000
Myelosuppression	34.06	9.49	19	189324	30126	70708975
Therapeutic product effect incomplete	33.69	9.49	185	189158	119697	70619404
Product quality issue	33.52	9.49	166	189177	30395	70708706
Oedema peripheral	33.10	9.49	820	188523	227271	70511830
Diabetic ketoacidosis	32.35	9.49	168	189175	31344	70707757
Renal impairment	32.29	9.49	552	188791	143385	70595716
Glycosylated haemoglobin increased	32.19	9.49	111	189232	17280	70721821
Hypoglycaemia	31.99	9.49	389	188954	93975	70645126
Malignant mediastinal neoplasm	31.94	9.49	23	189320	852	70738249
Memory impairment	31.88	9.49	383	188960	92258	70646843
Condition aggravated	31.71	9.49	884	188459	426751	70312350
Impaired healing	31.38	9.49	98	189245	74276	70664825
Haemophagocytic lymphohistiocytosis	31.28	9.49	7	189336	19605	70719496
Hypersensitivity	31.12	9.49	429	188914	229383	70509718
Abortion spontaneous	30.92	9.49	16	189327	26463	70712638
Dysphonia	30.67	9.49	234	189109	49866	70689235
Septic shock	30.58	9.49	175	189168	112083	70627018
Bundle branch block left	30.35	9.49	78	189265	10321	70728780
Vision blurred	30.24	9.49	387	188956	94597	70644504
Bone marrow failure	29.96	9.49	53	189290	48957	70690144
Blood pressure diastolic decreased	29.49	9.49	16	189327	25764	70713337
Graft versus host disease	29.33	9.49	3	189340	15020	70724081
Thrombocytopenia	29.03	9.49	456	188887	238654	70500447
Renal failure	28.71	9.49	684	188659	188386	70550715
Diabetic neuropathy	28.56	9.49	54	189289	5804	70733297
Sedation	28.14	9.49	51	189292	46680	70692421
Blood pressure diastolic abnormal	28.05	9.49	4	189339	15500	70723601
Anti-neutrophil cytoplasmic antibody positive vasculitis	27.86	9.49	39	189304	3258	70735843
Suspected suicide	27.60	9.49	68	189275	8766	70730335
Mucosal inflammation	27.51	9.49	91	189252	67759	70671342
Musculoskeletal stiffness	27.40	9.49	257	189086	147503	70591598
Bone erosion	27.25	9.49	4	189339	15169	70723932
Intentional overdose	27.05	9.49	153	189190	98282	70640819
Product odour abnormal	27.01	9.49	24	189319	1207	70737894
Blood pressure abnormal	26.98	9.49	97	189246	15417	70723684
Flatulence	26.63	9.49	184	189159	37997	70701104
Fibromyalgia	26.44	9.49	55	189288	47819	70691282
Premature delivery	26.21	9.49	12	189331	21292	70717809
Poisoning	25.93	9.49	14	189329	22608	70716493
Ageusia	25.91	9.49	93	189250	14769	70724332
Product use in unapproved indication	25.41	9.49	395	188948	207083	70532018
CD30 expression	24.88	9.49	8	189335	42	70739059
Psoriasis	24.87	9.49	385	188958	98048	70641053
Schizophrenia	24.78	9.49	7	189336	16761	70722340
Balance disorder	24.51	9.49	357	188986	89771	70649330
Diabetic foot	24.38	9.49	36	189307	3158	70735943
Dysgeusia	24.31	9.49	220	189123	49282	70689819
Haemorrhagic stroke	24.10	9.49	71	189272	10171	70728930
Live birth	23.91	9.49	4	189339	13775	70725326
Dry skin	23.72	9.49	241	189102	55690	70683411
Pneumonia aspiration	23.60	9.49	86	189257	62203	70676898
Serotonin syndrome	23.58	9.49	48	189295	42066	70697035
Full blood count decreased	23.51	9.49	126	189217	23792	70715309
Plasmapheresis	23.46	9.49	17	189326	636	70738465
Bradycardia	23.44	9.49	465	188878	124150	70614951
Acute myeloid leukaemia	23.25	9.49	29	189314	30911	70708190
Status epilepticus	22.97	9.49	19	189324	24507	70714594
Pathogen resistance	22.72	9.49	4	189339	13275	70725826
Hypotension	22.59	9.49	1307	188036	403074	70336027
Ascites	22.58	9.49	98	189245	67449	70671652
Chikungunya virus infection	22.45	9.49	11	189332	196	70738905
Renal disorder	22.42	9.49	176	189167	37833	70701268
Respiratory depression	22.33	9.49	20	189323	24811	70714290
Paraplegia	22.32	9.49	43	189300	4687	70734414
Loss of personal independence in daily activities	22.25	9.49	134	189209	84776	70654325
Cutaneous T-cell dyscrasia	22.24	9.49	8	189335	62	70739039
Mouth swelling	22.10	9.49	46	189297	5303	70733798
Immune reconstitution inflammatory syndrome	22.04	9.49	4	189339	12986	70726115
Oral pain	22.03	9.49	143	189200	28923	70710178
Blood pressure systolic abnormal	21.85	9.49	4	189339	12905	70726196
Cardiac valve disease	21.81	9.49	46	189297	5352	70733749
Mydriasis	21.65	9.49	8	189335	16145	70722956
Blood glucose decreased	21.57	9.49	124	189219	24035	70715066
Gastrointestinal haemorrhage	21.43	9.49	499	188844	136909	70602192
Generalised tonic-clonic seizure	21.25	9.49	50	189293	41611	70697490
Renal pain	21.01	9.49	56	189287	7574	70731527
Hyperlipidaemia	20.99	9.49	122	189221	23741	70715360
Pneumocystis jirovecii pneumonia	20.77	9.49	30	189313	30052	70709049
Diabetes mellitus inadequate control	20.72	9.49	117	189226	22528	70716573
Hepatocellular injury	20.69	9.49	59	189284	46032	70693069
Carcinogenicity	20.55	9.49	8	189335	79	70739022
Drug dependence	20.51	9.49	43	189300	37278	70701823
Swollen tongue	20.47	9.49	169	189174	36877	70702224
Noninfectious peritonitis	20.45	9.49	11	189332	240	70738861
Glomerulonephritis rapidly progressive	20.44	9.49	22	189321	1401	70737700
Posterior reversible encephalopathy syndrome	20.37	9.49	21	189322	24381	70714720
Recalled product administered	20.22	9.49	17	189326	793	70738308
Primary hyperaldosteronism	20.19	9.49	9	189334	128	70738973
Burning feet syndrome	20.17	9.49	10	189333	183	70738918
Haemorrhage intracranial	20.08	9.49	124	189219	24653	70714448
Red blood cell sedimentation rate increased	20.01	9.49	46	189297	38596	70700505
Dengue fever	19.95	9.49	17	189326	808	70738293
Drug interaction	19.81	9.49	1225	188118	380216	70358885
Febrile bone marrow aplasia	19.69	9.49	4	189339	11987	70727114
Intentional self-injury	19.55	9.49	34	189309	31616	70707485
Urinary tract infection	19.49	9.49	831	188512	247938	70491163
Sinusitis	19.42	9.49	326	189017	168869	70570232
Pain	19.24	9.49	1432	187911	627384	70111717
Gout	19.19	9.49	116	189227	22890	70716211
Ill-defined disorder	19.18	9.49	78	189265	54663	70684438
Progressive multifocal leukoencephalopathy	19.12	9.49	14	189329	19200	70719901
Urine albumin/creatinine ratio increased	19.08	9.49	13	189330	440	70738661
Hepatic failure	19.02	9.49	84	189259	57541	70681560
Myopathy	18.94	9.49	99	189244	18513	70720588
High frequency ablation	18.86	9.49	11	189332	282	70738819
Diffuse large B-cell lymphoma	18.84	9.49	6	189337	13296	70725805
Device expulsion	18.74	9.49	19	189324	22227	70716874
Pruritus	18.73	9.49	1114	188229	344446	70394655
Asthmatic crisis	18.54	9.49	24	189319	1860	70737241
Neurotoxicity	18.46	9.49	32	189311	29794	70709307
Transplant rejection	18.39	9.49	13	189330	18158	70720943
Pseudolymphoma	18.18	9.49	18	189325	1039	70738062
Erectile dysfunction	18.08	9.49	78	189265	13484	70725617
Gastrointestinal disorder	18.02	9.49	187	189156	105240	70633861
Haematotoxicity	17.95	9.49	7	189336	13667	70725434
Gastroenteritis eosinophilic	17.89	9.49	10	189333	236	70738865
Paraesthesia	17.87	9.49	512	188831	145025	70594076
Hepatic cytolysis	17.81	9.49	15	189328	19177	70719924
Abdominal pain upper	17.79	9.49	658	188685	192944	70546157
Blood pressure decreased	17.72	9.49	343	189000	91172	70647929
Blood urea increased	17.67	9.49	194	189149	45715	70693386
Sodium retention	17.67	9.49	9	189334	175	70738926
Dystonia	17.57	9.49	16	189327	19690	70719411
Oligohydramnios	17.22	9.49	31	189312	3209	70735892
Therapy interrupted	16.99	9.49	119	189224	24683	70714418
Atrioventricular block	16.93	9.49	73	189270	12615	70726486
Rhabdomyolysis	16.91	9.49	354	188989	95406	70643695
Cachexia	16.90	9.49	3	189340	9897	70729204
Panniculitis	16.65	9.49	4	189339	10672	70728429
Catarrh	16.63	9.49	13	189330	546	70738555
Blister	16.49	9.49	180	189163	100346	70638755
Mitral valve incompetence	16.45	9.49	125	189218	26603	70712498
Chronic obstructive pulmonary disease	16.42	9.49	295	189048	77346	70661755
Aggression	16.37	9.49	70	189273	48376	70690725
Cardiomegaly	16.36	9.49	117	189226	24428	70714673
Post transplant lymphoproliferative disorder	16.35	9.49	4	189339	10541	70728560
Dermatitis atopic	16.25	9.49	57	189286	8950	70730151
Thymus disorder	16.23	9.49	10	189333	284	70738817
Blood potassium decreased	16.21	9.49	179	189164	42242	70696859
Back pain	16.21	9.49	882	188461	270270	70468831
Carotid bruit	16.13	9.49	14	189329	682	70738419
Dehydration	16.07	9.49	748	188595	225394	70513707
Sedation complication	15.81	9.49	8	189335	13402	70725699
Depressed level of consciousness	15.80	9.49	153	189190	87278	70651823
Miosis	15.77	9.49	9	189334	14092	70725009
Eye irritation	15.68	9.49	91	189252	17697	70721404
Oral mucosal blistering	15.52	9.49	41	189302	5515	70733586
Drug hypersensitivity	15.44	9.49	559	188784	261900	70477201
Therapy partial responder	15.38	9.49	7	189336	12467	70726634
Nasopharyngitis	15.26	9.49	464	188879	221742	70517359
Multiple organ dysfunction syndrome	15.24	9.49	201	189142	108314	70630787
Tubulointerstitial nephritis	15.23	9.49	145	189198	32931	70706170
Bradyarrhythmia	15.18	9.49	33	189310	3920	70735181
Product residue present	15.13	9.49	30	189313	3340	70735761
Near death experience	15.08	9.49	11	189332	416	70738685
Peripheral swelling	15.04	9.49	774	188569	235789	70503312
Atheroembolism	14.98	9.49	9	189334	244	70738857
Fluid retention	14.91	9.49	245	189098	63140	70675961
Sialoadenitis	14.85	9.49	21	189322	1771	70737330
Hip arthroplasty	14.83	9.49	33	189310	28007	70711094
Disability	14.80	9.49	11	189332	14972	70724129
Carotid artery stenosis	14.75	9.49	52	189291	8184	70730917
Headache	14.74	9.49	1767	187576	578638	70160463
Granulocytopenia	14.74	9.49	5	189338	10642	70728459
Eosinophilia myalgia syndrome	14.73	9.49	4	189339	10	70739091
Drug tolerance decreased	14.73	9.49	4	189339	9829	70729272
Patella fracture	14.71	9.49	20	189323	1626	70737475
Guillain-Barre syndrome	14.61	9.49	51	189292	7989	70731112
Hepatotoxicity	14.59	9.49	64	189279	43922	70695179
Abdominal pain	14.47	9.49	756	188587	341371	70397730
Renal artery stenosis	14.46	9.49	29	189314	3255	70735846
Papillary muscle rupture	14.46	9.49	4	189339	11	70739090
Decreased immune responsiveness	14.45	9.49	37	189306	4884	70734217
Inappropriate antidiuretic hormone secretion	14.40	9.49	109	189234	23167	70715934
Product physical issue	14.26	9.49	31	189312	3683	70735418
Norepinephrine increased	14.23	9.49	6	189337	74	70739027
Neutropenic sepsis	14.16	9.49	28	189315	24802	70714299
Shoshin beriberi	14.08	9.49	6	189337	76	70739025
Extrapyramidal disorder	14.03	9.49	21	189322	20729	70718372
Therapeutic response unexpected	14.00	9.49	90	189253	18141	70720960
Heat stroke	13.98	9.49	19	189324	1544	70737557
Neutrophil count decreased	13.95	9.49	149	189194	83407	70655694
Chromaturia	13.90	9.49	109	189234	23419	70715682
Gamma-glutamyltransferase increased	13.80	9.49	79	189264	50606	70688495
Gait disturbance	13.74	9.49	615	188728	184491	70554610
Product supply issue	13.68	9.49	19	189324	1576	70737525
Hypertensive emergency	13.65	9.49	24	189319	2439	70736662
Aortic dissection	13.52	9.49	31	189312	3816	70735285
Blood pressure fluctuation	13.51	9.49	97	189246	58915	70680186
Diabetes mellitus	13.50	9.49	268	189075	71556	70667545
Bronchopulmonary aspergillosis	13.49	9.49	22	189321	20980	70718121
Cardiac flutter	13.42	9.49	34	189309	4459	70734642
Therapeutic response decreased	13.42	9.49	96	189247	58357	70680744
Hypoparathyroidism	13.39	9.49	15	189328	999	70738102
Accelerated hypertension	13.36	9.49	12	189331	612	70738489
Hypomagnesaemia	13.36	9.49	167	189176	40597	70698504
Venous occlusion	13.32	9.49	15	189328	1005	70738096
Cytokine release syndrome	13.31	9.49	32	189311	26435	70712666
Visual impairment	13.31	9.49	294	189049	79956	70659145
Delirium	13.30	9.49	131	189212	74483	70664618
Angina pectoris	13.29	9.49	192	189151	48191	70690910
Atrioventricular block first degree	13.23	9.49	64	189279	11609	70727492
Tendon rupture	13.21	9.49	62	189281	11107	70727994
Body temperature increased	13.19	9.49	58	189285	39776	70699325
Respiratory arrest	13.16	9.49	87	189256	53846	70685255
Lichen planus	13.15	9.49	24	189319	2511	70736590
Eczema nummular	13.12	9.49	9	189334	308	70738793
Insomnia	13.11	9.49	709	188634	217097	70522004
Orbital oedema	13.10	9.49	9	189334	309	70738792
Pseudoaldosteronism	13.09	9.49	7	189336	151	70738950
Hyperglycaemia	13.07	9.49	244	189099	64428	70674673
Pseudomonas infection	13.06	9.49	19	189324	18975	70720126
Coronary artery occlusion	13.05	9.49	74	189269	14271	70724830
Nodular rash	13.05	9.49	9	189334	311	70738790
Myeloma cast nephropathy	13.05	9.49	7	189336	152	70738949
Stomatitis	13.04	9.49	253	189090	128258	70610843
Decreased appetite	13.01	9.49	963	188380	303817	70435284
Vascular stenosis	12.94	9.49	11	189332	521	70738580
Hypovolaemia	12.94	9.49	80	189263	15913	70723188
Hypertensive encephalopathy	12.93	9.49	14	189329	898	70738203
Aortic stenosis	12.93	9.49	43	189300	6573	70732528
Non-cardiac chest pain	12.91	9.49	53	189290	8962	70730139
Injection site reaction	12.89	9.49	79	189264	49773	70689328
Ischaemic cardiomyopathy	12.85	9.49	45	189298	7059	70732042
Overweight	12.84	9.49	29	189314	3534	70735567
Liver injury	12.84	9.49	61	189282	40974	70698127
Low density lipoprotein increased	12.83	9.49	49	189294	8016	70731085
Enterococcal infection	12.81	9.49	12	189331	14570	70724531
Milk-alkali syndrome	12.80	9.49	16	189327	1197	70737904
Obstructive airways disorder	12.80	9.49	32	189311	26081	70713020
Blood triglycerides abnormal	12.75	9.49	10	189333	422	70738679
Weight decreased	12.74	9.49	978	188365	309510	70429591
B-cell small lymphocytic lymphoma stage IV	12.71	9.49	3	189340	3	70739098
Pollakiuria	12.70	9.49	141	189202	33320	70705781
Epstein-Barr virus infection	12.64	9.49	10	189333	13188	70725913
Tinnitus	12.63	9.49	150	189193	36026	70703075
Rash maculo-papular	12.60	9.49	81	189262	50464	70688637
Acute respiratory distress syndrome	12.51	9.49	62	189281	41192	70697909
Arrhythmia	12.47	9.49	215	189128	55928	70683173
Photopsia	12.44	9.49	35	189308	4886	70734215
Arrhythmia supraventricular	12.43	9.49	20	189323	1890	70737211
Hyperammonaemia	12.35	9.49	6	189337	10287	70728814
Eye haemorrhage	12.34	9.49	52	189291	8897	70730204
Cholestasis	12.31	9.49	76	189267	47796	70691305
Muscle spasticity	12.30	9.49	21	189322	19668	70719433
Electrocardiogram PR prolongation	12.17	9.49	17	189326	1417	70737684
Periorbital oedema	12.17	9.49	47	189296	7728	70731373
Blindness unilateral	12.10	9.49	45	189298	7268	70731833
Diabetic retinopathy	12.07	9.49	25	189318	2872	70736229
Agitation	12.03	9.49	176	189167	93199	70645902
Nasal congestion	11.99	9.49	244	189099	65428	70673673
Cerebellar haemorrhage	11.99	9.49	24	189319	2691	70736410
Nephrolithiasis	11.91	9.49	185	189158	47138	70691963
Wrong product administered	11.89	9.49	49	189294	8302	70730799
Multi-organ disorder	11.89	9.49	22	189321	2327	70736774
Gastroenteritis aeromonas	11.86	9.49	4	189339	25	70739076
Renin decreased	11.85	9.49	6	189337	115	70738986
Pancreatitis acute	11.85	9.49	178	189165	45046	70694055
Psychotic disorder	11.82	9.49	56	189287	37645	70701456
Ischaemic stroke	11.75	9.49	130	189213	30690	70708411
Eye pain	11.73	9.49	141	189202	33961	70705140
Generalised anxiety disorder	11.72	9.49	20	189323	1985	70737116
Mitral valve stenosis	11.69	9.49	15	189328	1152	70737949
Spider naevus	11.67	9.49	6	189337	119	70738982
Mobility decreased	11.63	9.49	199	189144	102800	70636301
Faeces discoloured	11.60	9.49	116	189227	26693	70712408
Nail bed tenderness	11.58	9.49	9	189334	375	70738726
Cardiac failure	11.57	9.49	481	188862	143060	70596041
Disease progression	11.54	9.49	324	189019	156348	70582753
Parathyroid haemorrhage	11.51	9.49	3	189340	6	70739095
Agranulocytosis	11.42	9.49	62	189281	40236	70698865
Tumour lysis syndrome	11.41	9.49	25	189318	21335	70717766
Alanine aminotransferase increased	11.38	9.49	303	189040	147177	70591924
Anticoagulation drug level above therapeutic	11.28	9.49	26	189317	3212	70735889
Application site scab	11.26	9.49	7	189336	202	70738899
Lymphocyte count decreased	11.25	9.49	69	189274	43470	70695631
Blood parathyroid hormone decreased	11.23	9.49	5	189338	9019	70730082
Diabetic metabolic decompensation	11.18	9.49	25	189318	3027	70736074
Alopecia	11.17	9.49	425	188918	198065	70541036
Hyperthermia	11.15	9.49	17	189326	16654	70722447
Haemorrhagic fever	11.12	9.49	4	189339	31	70739070
Hyponatraemic seizure	11.10	9.49	10	189333	512	70738589
Application site haematoma	11.10	9.49	5	189338	73	70739028
Cardiotoxicity	11.10	9.49	8	189335	11062	70728039
Anuria	11.04	9.49	90	189253	19563	70719538
Angiotensin converting enzyme inhibitor foetopathy	11.01	9.49	4	189339	32	70739069
Vitamin B6 deficiency	11.00	9.49	8	189335	301	70738800
Multiple-drug resistance	11.00	9.49	3	189340	7352	70731749
Fear	11.00	9.49	94	189249	20717	70718384
Hepatic steatosis	10.85	9.49	138	189205	33675	70705426
Extremity necrosis	10.82	9.49	24	189319	2890	70736211
Anhidrosis	10.76	9.49	7	189336	219	70738882
Parathyroid tumour	10.75	9.49	5	189338	79	70739022
Abdominal wall haematoma	10.70	9.49	31	189312	4399	70734702
Anosmia	10.69	9.49	33	189310	4850	70734251
Infective pulmonary exacerbation of cystic fibrosis	10.68	9.49	10	189333	12148	70726953
Blindness transient	10.68	9.49	31	189312	4405	70734696
Thrombosis	10.59	9.49	270	189073	75135	70663966
Body temperature decreased	10.59	9.49	40	189303	28632	70710469
Inflammation	10.58	9.49	147	189196	78518	70660583
Instillation site pain	10.55	9.49	11	189332	675	70738426
Respiratory rate increased	10.53	9.49	23	189320	19649	70719452
Hypersensitivity vasculitis	10.49	9.49	41	189302	6781	70732320
Unintentional medical device removal	10.48	9.49	3	189340	7121	70731980
Tachycardia	10.41	9.49	333	189010	158213	70580888
Eosinophilia	10.37	9.49	64	189279	40255	70698846
Umbilical hernia repair	10.37	9.49	5	189338	86	70739015
Extrasystoles	10.31	9.49	41	189302	6833	70732268
Blood loss anaemia	10.31	9.49	70	189273	14371	70724730
Cardiovascular disorder	10.28	9.49	78	189265	16592	70722509
Encephalopathy	10.28	9.49	110	189233	61551	70677550
Thyroid disorder	10.26	9.49	64	189279	12768	70726333
Orthopnoea	10.24	9.49	51	189292	9357	70729744
Loss of consciousness	10.20	9.49	511	188832	155205	70583896
Creatinine renal clearance decreased	10.15	9.49	19	189324	17181	70721920
Essential hypertension	10.15	9.49	35	189308	5449	70733652
Nightmare	10.14	9.49	97	189246	22059	70717042
Cardiorenal syndrome	10.14	9.49	16	189327	1488	70737613
Myocardial ischaemia	10.13	9.49	104	189239	24096	70715005
Dry mouth	10.11	9.49	253	189090	70204	70668897
Amenorrhoea	10.04	9.49	3	189340	6927	70732174
Blood magnesium decreased	10.04	9.49	71	189272	14770	70724331
Hair colour changes	10.01	9.49	28	189315	3895	70735206
Gastritis	9.99	9.49	171	189172	44420	70694681
Foreign body in respiratory tract	9.97	9.49	8	189335	349	70738752
Spinal epidural haematoma	9.97	9.49	15	189328	1338	70737763
Atrioventricular block complete	9.95	9.49	72	189271	15091	70724010
Encephalitis	9.93	9.49	13	189330	13572	70725529
Familial periodic paralysis	9.91	9.49	6	189337	165	70738936
Blood glucose abnormal	9.84	9.49	51	189292	9506	70729595
Amputation	9.78	9.49	10	189333	600	70738501
Expulsion of medication	9.73	9.49	4	189339	46	70739055
Sneezing	9.72	9.49	78	189265	16873	70722228
Lip swelling	9.70	9.49	136	189207	33918	70705183
Product dispensing error	9.67	9.49	60	189283	11948	70727153
Cardioactive drug level increased	9.66	9.49	26	189317	3536	70735565
Hair injury	9.62	9.49	3	189340	14	70739087
Otolithiasis	9.62	9.49	3	189340	14	70739087
Hypervitaminosis D	9.55	9.49	5	189338	103	70738998
Vascular parkinsonism	9.51	9.49	5	189338	104	70738997

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C09CA01	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN Angiotensin II receptor blockers (ARBs), plain
ATC	C09DA01	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and diuretics
ATC	C09DB06	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
FDA MoA	N0000000070	Angiotensin 2 Receptor Antagonists
FDA EPC	N0000175561	Angiotensin 2 Receptor Blocker
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:38070	antiarrhythmic agent
CHEBI has role	CHEBI:51451	ERA
CHEBI has role	CHEBI:61016	angiotensin receptor antagonists
MeSH PA	D047228	Angiotensin II Type 1 Receptor Blockers
MeSH PA	D057911	Angiotensin Receptor Antagonists
MeSH PA	D000889	Anti-Arrhythmia Agents
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Diabetic renal disease	indication	127013003
Hypertensive urgency	indication	443482000
Hypertension with Left Ventricular Hypertrophy	indication
Chronic heart failure	off-label use	48447003
Atrial fibrillation	off-label use	49436004	DOID:0060224
Diastolic heart failure	off-label use	418304008	DOID:9775
Nondiabetic Proteinuric Nephropathy	off-label use
Anuria	contraindication	2472002	DOID:2983
Hypercholesterolemia	contraindication	13644009
Hyperkalemia	contraindication	14140009
Secondary angle-closure glaucoma	contraindication	21571006
Hypovolemia	contraindication	28560003
Dehydration	contraindication	34095006
Hyperuricemia	contraindication	35885006	DOID:1920
Hypokalemia	contraindication	43339004
Low blood pressure	contraindication	45007003
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Sympathectomy	contraindication	57071006
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Hypochloremic alkalosis	contraindication	70134007
Hepatic coma	contraindication	72836002	DOID:12550
Diabetes mellitus	contraindication	73211009	DOID:9351
Hyponatremia	contraindication	89627008
Gout	contraindication	90560007	DOID:13189
Hypomagnesemia	contraindication	190855004
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Disease of liver	contraindication	235856003	DOID:409
Neonatal hyperbilirubinemia	contraindication	281610001
Pregnancy, function	contraindication	289908002
Renal artery stenosis	contraindication	302233006
Azotemia	contraindication	445009001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.5	acidic
pKa2	13.19	acidic
pKa3	3.89	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Type-1 angiotensin II receptor	GPCR	P30556	AGTR1_HUMAN	ANTAGONIST	IC50	9.48	CHEMBL	CHEMBL
Angiotensin-converting enzyme	Enzyme	P12821	ACE_HUMAN		IC50	7.72	CHEMBL
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	5.54	DRUG MATRIX
Thromboxane A2 receptor	GPCR	P21731	TA2R_HUMAN		IC50	4.70	CHEMBL
Type-2 angiotensin II receptor	GPCR	P50052	AGTR2_HUMAN		IC50	5	CHEMBL
Phosphodiesterase 3	Enzyme	Q13370 Q14432	PDE3B_HUMAN PDE3A_HUMAN		IC50	4.89	CHEMBL
Phosphodiesterase 4	Enzyme	P27815 Q07343 Q08493 Q08499	PDE4A_HUMAN PDE4B_HUMAN PDE4C_HUMAN PDE4D_HUMAN		IC50	4.59	CHEMBL
Angiotensin II receptor	GPCR	P30556 P50052	AGTR1_HUMAN AGTR2_HUMAN		Kd	8.43	CHEMBL
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Km	3.50	WOMBAT-PK
Platelet glycoprotein VI	Unclassified	Q9HCN6	GPVI_HUMAN		IC50	4.98	CHEMBL
Type-1B angiotensin II receptor	GPCR		AGTRB_RAT		Ki	8.44	CHEMBL
Type-2 angiotensin II receptor	GPCR		AGTR2_RAT		IC50	5.13	CHEMBL
Type-1 angiotensin II receptor	GPCR		AGTR1_BOVIN		IC50	7.02	CHEMBL
Type-1A angiotensin II receptor	GPCR		AGTRA_RAT		Ki	7.84	CHEMBL
Type-1 angiotensin II receptor	GPCR		AGTR1_RABIT		Kd	8.80	CHEMBL
Type-1 angiotensin II receptor	GPCR		AGTR1_CAVPO		IC50	7.74	CHEMBL
Angiotensin II receptor (AT-1) type-1	GPCR		AGTRA_RAT AGTRB_RAT		Ki	8.72	CHEMBL
Angiotensin II receptor	GPCR		AGTRA_RAT AGTRB_RAT AGTR2_RAT		IC50	8.34	CHEMBL

External reference:

ID	Source
4020913	VUID
N0000148401	NUI
D00357	KEGG_DRUG
124750-99-8	SECONDARY_CAS_RN
4020913	VANDF
4020920	VANDF
C0126174	UMLSCUI
CHEBI:6541	CHEBI
LSN	PDB_CHEM_ID
CHEMBL191	ChEMBL_ID
CHEMBL995	ChEMBL_ID
D019808	MESH_DESCRIPTOR_UI
DB00678	DRUGBANK_ID
3961	PUBCHEM_CID
590	IUPHAR_LIGAND_ID
6913	INN_ID
JMS50MPO89	UNII
203160	RXNORM
172424	MMSL
4996	MMSL
d03821	MMSL
004991	NDDF
004992	NDDF
108582002	SNOMEDCT_US
373567002	SNOMEDCT_US
96309000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0123	TABLET	25 mg	ORAL	ANDA	26 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0124	TABLET	50 mg	ORAL	ANDA	26 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0125	TABLET	100 mg	ORAL	ANDA	26 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7367	TABLET, FILM COATED	50 mg	ORAL	ANDA	26 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7367	TABLET, FILM COATED	50 mg	ORAL	ANDA	26 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7368	TABLET, FILM COATED	100 mg	ORAL	ANDA	26 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7368	TABLET, FILM COATED	100 mg	ORAL	ANDA	26 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7369	TABLET, FILM COATED	100 mg	ORAL	ANDA	26 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7369	TABLET, FILM COATED	100 mg	ORAL	ANDA	26 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7958	TABLET, FILM COATED	25 mg	ORAL	ANDA	28 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7959	TABLET, FILM COATED	50 mg	ORAL	ANDA	28 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7960	TABLET, FILM COATED	100 mg	ORAL	ANDA	28 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7047	TABLET, FILM COATED	25 mg	ORAL	ANDA	27 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7047	TABLET, FILM COATED	25 mg	ORAL	ANDA	27 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7048	TABLET, FILM COATED	50 mg	ORAL	ANDA	27 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7048	TABLET, FILM COATED	50 mg	ORAL	ANDA	27 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7049	TABLET, FILM COATED	100 mg	ORAL	ANDA	27 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7049	TABLET, FILM COATED	100 mg	ORAL	ANDA	27 sections
LOSARTAN POTASSIUM	Human Prescription Drug Label	1	13107-195	TABLET	25 mg	ORAL	ANDA	27 sections
LOSARTAN POTASSIUM	Human Prescription Drug Label	1	13107-196	TABLET	50 mg	ORAL	ANDA	27 sections
LOSARTAN POTASSIUM	Human Prescription Drug Label	1	13107-197	TABLET	100 mg	ORAL	ANDA	27 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	13668-113	TABLET	25 mg	ORAL	ANDA	28 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	13668-113	TABLET	25 mg	ORAL	ANDA	28 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	13668-115	TABLET	100 mg	ORAL	ANDA	28 sections
Losartan Potassium	HUMAN PRESCRIPTION DRUG LABEL	1	13668-115	TABLET	100 mg	ORAL	ANDA	28 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	13668-116	TABLET	50 mg	ORAL	ANDA	25 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	13668-116	TABLET	50 mg	ORAL	ANDA	25 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	13668-117	TABLET	100 mg	ORAL	ANDA	25 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	13668-117	TABLET	100 mg	ORAL	ANDA	25 sections
Losartan Potassium and Hydrochlorothiazide	HUMAN PRESCRIPTION DRUG LABEL	2	13668-118	TABLET	100 mg	ORAL	ANDA	25 sections