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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
clevidipine ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
calcium channel blockers, nifedipine derivatives
674
167221-71-8
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
clevidipine
clevelox
cleviprex
a calcium channel blocker and antihypertensive agent
Molecular weight: 456.32
Formula: C21H23Cl2NO6
CLOGP: 5.53
LIPINSKI: 1
HAC: 7
HDO: 1
TPSA: 90.93
ALOGS: -5.23
ROTB: 10
Status: OFP
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)
15.65 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
CL (Clearance)
142 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.58 L/kg
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
0.30 hours
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.00 %
Lombardo F, Berellini G, Obach RS
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Approvals:
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Date
Agency
Company
Orphan
Aug. 1, 2008
FDA
MEDICINES CO
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C08CA16
CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
FDA CS
M0006414
Dihydropyridines
FDA EPC
N0000175421
Dihydropyridine Calcium Channel Blocker
FDA MoA
N0000000069
Calcium Channel Antagonists
MeSH PA
D002121
Calcium Channel Blockers
MeSH PA
D000077264
Calcium-Regulating Hormones and Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D049990
Membrane Transport Modulators
Showing 1 to 8 of 8 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hypertensive disorder
indication
38341003
DOID:10763
Tachyarrhythmia
contraindication
6285003
Minimal change disease
contraindication
44785005
DOID:10966
Low blood pressure
contraindication
45007003
Pancreatitis
contraindication
75694006
DOID:4989
Heart failure
contraindication
84114007
DOID:6000
Hypertriglyceridemia
contraindication
302870006
Severe Aortic Valve Stenosis
contraindication
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
0.56
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Voltage-dependent L-type calcium channel subunit alpha-1C
Ion channel
Q13936
CAC1C_HUMAN
BLOCKER
WOMBAT-PK
CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D
Ion channel
Q01668
CAC1D_HUMAN
BLOCKER
WOMBAT-PK
CHEMBL
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External reference:
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ID
Source
012824
NDDF
147455
MMSL
153994
PUBCHEM_CID
19O2GP3B7Q
UNII
233603
RXNORM
4028719
VUID
4028719
VANDF
439471002
SNOMEDCT_US
439624003
SNOMEDCT_US
7468
IUPHAR_LIGAND_ID
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
Cleviprex
HUMAN PRESCRIPTION DRUG LABEL
1
10122-610
EMULSION
0.50 mg
INTRAVENOUS
NDA
25 sections
Cleviprex
HUMAN PRESCRIPTION DRUG LABEL
1
10122-610
EMULSION
0.50 mg
INTRAVENOUS
NDA
25 sections
Cleviprex
HUMAN PRESCRIPTION DRUG LABEL
1
10122-610
EMULSION
0.50 mg
INTRAVENOUS
NDA
25 sections
Cleviprex
HUMAN PRESCRIPTION DRUG LABEL
1
10122-611
EMULSION
0.50 mg
INTRAVENOUS
NDA
25 sections
Cleviprex
HUMAN PRESCRIPTION DRUG LABEL
1
10122-611
EMULSION
0.50 mg
INTRAVENOUS
NDA
25 sections
Cleviprex
HUMAN PRESCRIPTION DRUG LABEL
1
10122-611
EMULSION
0.50 mg
INTRAVENOUS
NDA
25 sections
Cleviprex
HUMAN PRESCRIPTION DRUG LABEL
1
18124-011
EMULSION
0.50 mg
INTRAVENOUS
NDA
29 sections
Cleviprex
HUMAN PRESCRIPTION DRUG LABEL
1
18124-011
EMULSION
0.50 mg
INTRAVENOUS
NDA
29 sections
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clevidipine