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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
manidipine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
calcium channel blockers, nifedipine derivatives
1631
89226-50-6
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
manidipine dihydrochloride
manidipine
(+/-)-Manidipine
franidipine
manidipine hydrochloride
manidipine HCl
Molecular weight: 610.71
Formula: C35H38N4O6
CLOGP: 7.02
LIPINSKI: 2
HAC: 10
HDO: 1
TPSA: 114.25
ALOGS: -5.79
ROTB: 12
Drug dosage:
Dose
Unit
Route
10
mg
O
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Hyponatraemia
63.19
37.07
27
549
111873
63376573
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1
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Drug interaction
73.87
37.61
53
799
225893
34730186
Trichoglossia
61.38
37.61
10
842
318
34955761
Dermatitis bullous
43.75
37.61
13
839
6909
34949170
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1
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Drug interaction
94.27
29.99
72
1495
415111
79327710
Hyponatraemia
87.23
29.99
50
1517
177798
79565023
Acute kidney injury
59.10
29.99
61
1506
519343
79223478
Trichoglossia
56.54
29.99
10
1557
649
79742172
Dermatitis bullous
37.23
29.99
13
1554
14232
79728589
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C08CA11
CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC
C09BB12
CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
MeSH PA
D000959
Antihypertensive Agents
MeSH PA
D002121
Calcium Channel Blockers
MeSH PA
D000077264
Calcium-Regulating Hormones and Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D049990
Membrane Transport Modulators
Showing 1 to 7 of 7 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
6.7
Basic
pKa2
2.87
Basic
pKa3
2.2
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Voltage-gated L-type calcium channel
Ion channel
Q01668
Q13936
CAC1D_HUMAN
CAC1C_HUMAN
BLOCKER
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Cruzipain
Enzyme
CYSP_TRYCR
IC50
5.22
CHEMBL
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External reference:
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ID
Source
008164
NDDF
008165
NDDF
11739
IUPHAR_LIGAND_ID
259487
RXNORM
4008
PUBCHEM_CID
6300
INN_ID
6O4754US88
UNII
765322004
SNOMEDCT_US
765323009
SNOMEDCT_US
89226-75-5
SECONDARY_CAS_RN
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Pharmaceutical products:
None
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manidipine