benidipine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 3880 105979-17-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benidipine
  • benidipine hydrochloride
  • coniel
  • benidipine HCl
  • Molecular weight: 505.57
  • Formula: C28H31N3O6
  • CLOGP: 5.71
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -5.32
  • ROTB: 9

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.90 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.23 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1991 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 94.47 27.15 43 2630 36856 53309537
Cerebral infarction 67.33 27.15 30 2643 24414 53321979
Inappropriate antidiuretic hormone secretion 63.55 27.15 25 2648 14926 53331467
Renal impairment 48.11 27.15 37 2636 83281 53263112
Blood urea increased 44.23 27.15 23 2650 26208 53320185
Blood creatinine increased 44.02 27.15 35 2638 82627 53263766
Altered state of consciousness 42.52 27.15 22 2651 24814 53321579
Cardiac failure 36.67 27.15 32 2641 85812 53260581
Platelet count decreased 35.89 27.15 35 2638 108064 53238329
Decreased appetite 31.79 27.15 46 2627 214928 53131465
Interstitial lung disease 29.44 27.15 24 2649 58598 53287795

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 76.66 24.08 57 3009 64944 32445516
Cerebral infarction 46.05 24.08 30 3036 27584 32482876
Renal impairment 44.79 24.08 49 3017 91923 32418537
Hepatic function abnormal 43.36 24.08 35 3031 44805 32465655
Platelet count decreased 37.66 24.08 50 3016 114541 32395919
Blood urea increased 32.90 24.08 26 3040 32247 32478213
Liver disorder 31.20 24.08 25 3041 31629 32478831
Cardiac failure 30.08 24.08 40 3026 91633 32418827
Dyslalia 26.94 24.08 7 3059 580 32509880

Pharmacologic Action:

SourceCodeDescription
ATC C08CA15 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.05 Basic
pKa2 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER IC50 5.31 IUPHAR SCIENTIFIC LITERATURE
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel BLOCKER IC50 6.84 SCIENTIFIC LITERATURE

External reference:

IDSource
D02045 KEGG_DRUG
91599-74-5 SECONDARY_CAS_RN
C0053108 UMLSCUI
CHEBI:135806 CHEBI
CHEMBL2074972 ChEMBL_ID
CHEMBL2105555 ChEMBL_ID
CHEMBL2218858 ChEMBL_ID
DB09231 DRUGBANK_ID
C061004 MESH_SUPPLEMENTAL_RECORD_UI
10159 IUPHAR_LIGAND_ID
C050883 MESH_SUPPLEMENTAL_RECORD_UI
6137 INN_ID
4G9T91JS7E UNII
656668 PUBCHEM_CID
008170 NDDF
008171 NDDF

Pharmaceutical products:

None