benidipine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 3880 105979-17-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benidipine
  • benidipine hydrochloride
  • coniel
  • benidipine HCl
  • Molecular weight: 505.57
  • Formula: C28H31N3O6
  • CLOGP: 5.71
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -5.32
  • ROTB: 9

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.90 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.23 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1991 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 93.43 25.99 43 2530 34378 46649111
Cerebral infarction 62.76 25.99 29 2544 23337 46660152
Inappropriate antidiuretic hormone secretion 62.67 25.99 25 2548 14077 46669412
Renal impairment 46.52 25.99 36 2537 74336 46609153
Blood urea increased 42.91 25.99 23 2550 25329 46658160
Altered state of consciousness 41.83 25.99 22 2551 23326 46660163
Blood creatinine increased 37.26 25.99 32 2541 76371 46607118
Cardiac failure 34.03 25.99 31 2542 79917 46603572
Platelet count decreased 33.53 25.99 34 2539 99990 46583499
Decreased appetite 32.09 25.99 46 2527 193790 46489699
Interstitial lung disease 29.18 25.99 24 2549 53925 46629564
Hyperuricaemia 26.78 25.99 10 2563 4707 46678782
Disseminated intravascular coagulation 26.01 25.99 15 2558 18990 46664499

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 71.39 23.42 54 2910 60143 29889371
Hepatic function abnormal 43.93 23.42 35 2929 41910 29907604
Cerebral infarction 43.56 23.42 29 2935 26344 29923170
Renal impairment 42.91 23.42 47 2917 84137 29865377
Platelet count decreased 38.79 23.42 50 2914 106079 29843435
Blood urea increased 32.44 23.42 26 2938 31355 29918159
Liver disorder 31.53 23.42 25 2939 29697 29919817
Cardiac failure 28.42 23.42 38 2926 83380 29866134
Dyslalia 27.61 23.42 7 2957 501 29949013
Drug eruption 23.58 23.42 17 2947 17509 29932005
Blood pressure decreased 23.44 23.42 26 2938 47049 29902465
Prinzmetal angina 23.43 23.42 7 2957 922 29948592

Pharmacologic Action:

SourceCodeDescription
ATC C08CA15 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.05 Basic
pKa2 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel BLOCKER IC50 6.84 SCIENTIFIC LITERATURE

External reference:

IDSource
4G9T91JS7E UNII
D02045 KEGG_DRUG
91599-74-5 SECONDARY_CAS_RN
C0053108 UMLSCUI
CHEBI:135806 CHEBI
CHEMBL2074972 ChEMBL_ID
CHEMBL2105555 ChEMBL_ID
CHEMBL2218858 ChEMBL_ID
DB09231 DRUGBANK_ID
6137 INN_ID
C061004 MESH_SUPPLEMENTAL_RECORD_UI
C050883 MESH_SUPPLEMENTAL_RECORD_UI
656668 PUBCHEM_CID
10159 IUPHAR_LIGAND_ID
008170 NDDF
008171 NDDF

Pharmaceutical products:

None