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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
benidipine ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
calcium channel blockers, nifedipine derivatives
3880
105979-17-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
benidipine
benidipine hydrochloride
coniel
benidipine HCl
Molecular weight: 505.57
Formula: C28H31N3O6
CLOGP: 5.71
LIPINSKI: 2
HAC: 9
HDO: 1
TPSA: 111.01
ALOGS: -5.32
ROTB: 9
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
S (Water solubility)
1.90 mg/mL
Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)
1 %
Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)
1
Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)
0.23 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
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Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1991
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Inappropriate antidiuretic hormone secretion
61.41
33.43
19
1140
15443
63472420
Cerebral infarction
45.83
33.43
17
1142
23876
63463987
Hepatic function abnormal
45.15
33.43
19
1140
37123
63450740
Altered state of consciousness
37.80
33.43
15
1144
25215
63462648
Renal impairment
34.67
33.43
21
1138
88334
63399529
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Interstitial lung disease
52.29
27.49
32
1312
65250
34890337
Cerebral infarction
37.09
27.49
19
1325
27436
34928151
Renal impairment
35.11
27.49
29
1315
94484
34861103
Cardiac failure
31.82
27.49
27
1317
91221
34864366
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Cerebral infarction
74.72
24.93
35
2764
45641
79695948
Renal impairment
61.52
24.93
48
2751
157735
79583854
Interstitial lung disease
61.48
24.93
42
2757
112558
79629031
Hepatic function abnormal
56.60
24.93
34
2765
73073
79668516
Cardiac failure
47.51
24.93
41
2758
154801
79586788
Altered state of consciousness
46.34
24.93
25
2774
43797
79697792
Inappropriate antidiuretic hormone secretion
45.60
24.93
21
2778
26292
79715297
Platelet count decreased
41.33
24.93
42
2757
194622
79546967
Erythema multiforme
27.22
24.93
13
2786
17638
79723951
Colon cancer
26.44
24.93
12
2787
14511
79727078
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C08CA15
CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA
D002121
Calcium Channel Blockers
MeSH PA
D000077264
Calcium-Regulating Hormones and Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D049990
Membrane Transport Modulators
MeSH PA
D014665
Vasodilator Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.05
Basic
pKa2
2.23
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Voltage-gated L-type calcium channel
Ion channel
Q01668
Q13936
CAC1D_HUMAN
CAC1C_HUMAN
BLOCKER
IC50
5.31
IUPHAR
SCIENTIFIC LITERATURE
Voltage-dependent T-type calcium channel subunit alpha-1H
Ion channel
O95180
CAC1H_HUMAN
BLOCKER
IC50
6.84
SCIENTIFIC LITERATURE
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External reference:
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ID
Source
008170
NDDF
008171
NDDF
10159
IUPHAR_LIGAND_ID
4G9T91JS7E
UNII
6137
INN_ID
656668
PUBCHEM_CID
91599-74-5
SECONDARY_CAS_RN
C0053108
UMLSCUI
C050883
MESH_SUPPLEMENTAL_RECORD_UI
C061004
MESH_SUPPLEMENTAL_RECORD_UI
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Pharmaceutical products:
None
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benidipine