Stem definition | Drug id | CAS RN |
---|---|---|
angiotensin-converting enzyme inhibitors | 299 | 86541-75-5 |
Dose | Unit | Route |
---|---|---|
7.50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 78 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.13 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 18 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
June 25, 1991 | FDA | US PHARMS HOLDINGS I |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 142.96 | 12.65 | 111 | 16890 | 37565 | 50550558 |
Cerebrovascular accident | 117.99 | 12.65 | 152 | 16849 | 94528 | 50493595 |
Coronary artery disease | 107.17 | 12.65 | 85 | 16916 | 29641 | 50558482 |
Myocardial infarction | 104.81 | 12.65 | 139 | 16862 | 88888 | 50499235 |
Cardiac failure congestive | 95.11 | 12.65 | 129 | 16872 | 84253 | 50503870 |
Off label use | 55.36 | 12.65 | 47 | 16954 | 474379 | 50113744 |
Drug ineffective | 50.68 | 12.65 | 127 | 16874 | 819206 | 49768917 |
Maternal exposure during pregnancy | 42.10 | 12.65 | 3 | 16998 | 159775 | 50428348 |
Transient ischaemic attack | 40.50 | 12.65 | 52 | 16949 | 32158 | 50555965 |
Chest pain | 39.59 | 12.65 | 140 | 16861 | 176742 | 50411381 |
Contraindicated product administered | 38.67 | 12.65 | 3 | 16998 | 148955 | 50439168 |
Blood pressure inadequately controlled | 36.31 | 12.65 | 21 | 16980 | 4359 | 50583764 |
Swollen tongue | 34.09 | 12.65 | 45 | 16956 | 28585 | 50559538 |
Drug intolerance | 33.29 | 12.65 | 16 | 16985 | 219088 | 50369035 |
Dizziness | 33.03 | 12.65 | 214 | 16787 | 346155 | 50241968 |
Mitral valve incompetence | 31.62 | 12.65 | 34 | 16967 | 17437 | 50570686 |
Vasodilatation | 30.40 | 12.65 | 15 | 16986 | 2264 | 50585859 |
Treatment failure | 30.17 | 12.65 | 5 | 16996 | 137632 | 50450491 |
Oropharyngeal swelling | 30.02 | 12.65 | 11 | 16990 | 795 | 50587328 |
Carotid artery stenosis | 29.74 | 12.65 | 19 | 16982 | 4712 | 50583411 |
Infusion related reaction | 29.63 | 12.65 | 10 | 16991 | 169547 | 50418576 |
Product complaint | 29.44 | 12.65 | 27 | 16974 | 11439 | 50576684 |
Renal failure | 28.82 | 12.65 | 90 | 16911 | 106543 | 50481580 |
Oedema peripheral | 28.69 | 12.65 | 117 | 16884 | 157844 | 50430279 |
Arteriosclerosis | 28.58 | 12.65 | 24 | 16977 | 9053 | 50579070 |
Angina unstable | 28.14 | 12.65 | 21 | 16980 | 6685 | 50581438 |
Systemic lupus erythematosus | 26.93 | 12.65 | 7 | 16994 | 140615 | 50447508 |
Kounis syndrome | 26 | 12.65 | 11 | 16990 | 1164 | 50586959 |
Cardiac disorder | 24.13 | 12.65 | 48 | 16953 | 42931 | 50545192 |
Emotional distress | 23.82 | 12.65 | 38 | 16963 | 28625 | 50559498 |
Cardiovascular disorder | 23.75 | 12.65 | 23 | 16978 | 10431 | 50577692 |
Glossodynia | 23.61 | 12.65 | 5 | 16996 | 115564 | 50472559 |
Injury | 23.22 | 12.65 | 51 | 16950 | 48874 | 50539249 |
Exposure during pregnancy | 23.21 | 12.65 | 6 | 16995 | 121009 | 50467114 |
Completed suicide | 22.61 | 12.65 | 96 | 16905 | 131793 | 50456330 |
Tricuspid valve incompetence | 21.62 | 12.65 | 24 | 16977 | 12746 | 50575377 |
Renal injury | 21.57 | 12.65 | 20 | 16981 | 8591 | 50579532 |
Reaction to excipient | 19.63 | 12.65 | 9 | 16992 | 1153 | 50586970 |
Depression | 19.41 | 12.65 | 108 | 16893 | 165315 | 50422808 |
Wound | 18.89 | 12.65 | 6 | 16995 | 105788 | 50482335 |
Rhabdomyolysis | 18.88 | 12.65 | 41 | 16960 | 38986 | 50549137 |
Blood pressure increased | 18.43 | 12.65 | 91 | 16910 | 133041 | 50455082 |
Gastrooesophageal reflux disease | 18.37 | 12.65 | 62 | 16939 | 76366 | 50511757 |
Hyperdynamic left ventricle | 18.01 | 12.65 | 5 | 16996 | 146 | 50587977 |
Arteriosclerosis coronary artery | 17.72 | 12.65 | 17 | 16984 | 7619 | 50580504 |
Swelling face | 17.67 | 12.65 | 48 | 16953 | 52547 | 50535576 |
Fear | 17.52 | 12.65 | 23 | 16978 | 14526 | 50573597 |
Gastrointestinal haemorrhage | 17.20 | 12.65 | 59 | 16942 | 73262 | 50514861 |
Palpitations | 17.14 | 12.65 | 70 | 16931 | 94436 | 50493687 |
Vasoplegia syndrome | 16.87 | 12.65 | 8 | 16993 | 1106 | 50587017 |
Dehydration | 16.87 | 12.65 | 98 | 16903 | 152351 | 50435772 |
Keratoacanthoma | 16.56 | 12.65 | 6 | 16995 | 420 | 50587703 |
Coronary artery occlusion | 16.10 | 12.65 | 16 | 16985 | 7487 | 50580636 |
Tendon rupture | 14.89 | 12.65 | 15 | 16986 | 7129 | 50580994 |
Rhinitis allergic | 14.80 | 12.65 | 15 | 16986 | 7185 | 50580938 |
Blood glucose increased | 14.69 | 12.65 | 55 | 16946 | 71269 | 50516854 |
Peripheral vascular disorder | 14.28 | 12.65 | 13 | 16988 | 5454 | 50582669 |
Blood urea increased | 14.04 | 12.65 | 27 | 16974 | 23558 | 50564565 |
Pyrexia | 13.98 | 12.65 | 73 | 16928 | 380130 | 50207993 |
Joint swelling | 13.55 | 12.65 | 40 | 16961 | 245246 | 50342877 |
Hiatus hernia | 13.46 | 12.65 | 23 | 16978 | 18321 | 50569802 |
C-reactive protein increased | 13.32 | 12.65 | 3 | 16998 | 66471 | 50521652 |
Pericarditis | 13.12 | 12.65 | 5 | 16996 | 78684 | 50509439 |
Cardiomegaly | 13.05 | 12.65 | 21 | 16980 | 15924 | 50572199 |
Laryngeal pain | 13.01 | 12.65 | 11 | 16990 | 4188 | 50583935 |
Hyperlipidaemia | 12.93 | 12.65 | 22 | 16979 | 17468 | 50570655 |
Haemorrhoids | 12.83 | 12.65 | 23 | 16978 | 19030 | 50569093 |
Muscle spasms | 12.79 | 12.65 | 79 | 16922 | 125474 | 50462649 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 193.06 | 13.42 | 141 | 13483 | 31774 | 29529129 |
Myocardial infarction | 122.93 | 13.42 | 198 | 13426 | 110098 | 29450805 |
Coronary artery disease | 101.35 | 13.42 | 113 | 13511 | 44077 | 29516826 |
Cardiac failure congestive | 69.98 | 13.42 | 126 | 13498 | 76455 | 29484448 |
Cerebrovascular accident | 67.06 | 13.42 | 124 | 13500 | 76787 | 29484116 |
Off label use | 47.99 | 13.42 | 41 | 13583 | 300759 | 29260144 |
Injury | 32.58 | 13.42 | 42 | 13582 | 19004 | 29541899 |
Swollen tongue | 29.16 | 13.42 | 32 | 13592 | 12234 | 29548669 |
Chest pain | 26.55 | 13.42 | 112 | 13512 | 111861 | 29449042 |
Product complaint | 26.28 | 13.42 | 21 | 13603 | 5384 | 29555519 |
Emotional distress | 25.92 | 13.42 | 32 | 13592 | 13863 | 29547040 |
Blood glucose increased | 24.44 | 13.42 | 71 | 13553 | 58913 | 29501990 |
Nodular rash | 22.70 | 13.42 | 6 | 13618 | 104 | 29560799 |
Lymphomatoid papulosis | 19.52 | 13.42 | 6 | 13618 | 182 | 29560721 |
Blood pressure inadequately controlled | 17.79 | 13.42 | 12 | 13612 | 2374 | 29558529 |
Neutropenia | 17.45 | 13.42 | 21 | 13603 | 131690 | 29429213 |
Blood gases abnormal | 17.09 | 13.42 | 6 | 13618 | 278 | 29560625 |
Carotid artery stenosis | 16.85 | 13.42 | 15 | 13609 | 4454 | 29556449 |
Asthenia | 16.83 | 13.42 | 162 | 13462 | 215088 | 29345815 |
Shock | 16.74 | 13.42 | 33 | 13591 | 21371 | 29539532 |
Pancreatitis | 16.72 | 13.42 | 44 | 13580 | 34470 | 29526433 |
Depression | 16.30 | 13.42 | 80 | 13544 | 85067 | 29475836 |
Lip swelling | 16.16 | 13.42 | 24 | 13600 | 12386 | 29548517 |
Hyperlipidaemia | 15.90 | 13.42 | 24 | 13600 | 12566 | 29548337 |
Angina unstable | 15.59 | 13.42 | 22 | 13602 | 10843 | 29550060 |
Acute myocardial infarction | 15.20 | 13.42 | 53 | 13571 | 48385 | 29512518 |
Dizziness | 14.93 | 13.42 | 143 | 13481 | 189541 | 29371362 |
Product use in unapproved indication | 14.85 | 13.42 | 11 | 13613 | 86864 | 29474039 |
Fear | 14.77 | 13.42 | 20 | 13604 | 9484 | 29551419 |
Toxicity to various agents | 14.54 | 13.42 | 37 | 13587 | 173624 | 29387279 |
Type 2 diabetes mellitus | 14.54 | 13.42 | 24 | 13600 | 13557 | 29547346 |
Nephrogenic systemic fibrosis | 14.41 | 13.42 | 13 | 13611 | 3929 | 29556974 |
Drug interaction | 14.35 | 13.42 | 45 | 13579 | 197340 | 29363563 |
Cardiovascular disorder | 14.19 | 13.42 | 19 | 13605 | 8916 | 29551987 |
Anxiety | 14.12 | 13.42 | 77 | 13547 | 85288 | 29475615 |
General physical health deterioration | 14.05 | 13.42 | 16 | 13608 | 102841 | 29458062 |
Lacunar infarction | 13.81 | 13.42 | 11 | 13613 | 2808 | 29558095 |
Transient ischaemic attack | 13.73 | 13.42 | 32 | 13592 | 23238 | 29537665 |
Pharyngeal oedema | 13.70 | 13.42 | 15 | 13609 | 5719 | 29555184 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 286.25 | 12.10 | 214 | 23887 | 61607 | 64413024 |
Myocardial infarction | 234.74 | 12.10 | 299 | 23802 | 165522 | 64309109 |
Coronary artery disease | 223.02 | 12.10 | 183 | 23918 | 60250 | 64414381 |
Cerebrovascular accident | 178.86 | 12.10 | 238 | 23863 | 137345 | 64337286 |
Cardiac failure congestive | 142.91 | 12.10 | 208 | 23893 | 130372 | 64344259 |
Off label use | 89.44 | 12.10 | 64 | 24037 | 632742 | 63841889 |
Transient ischaemic attack | 50.61 | 12.10 | 72 | 24029 | 44110 | 64430521 |
Chest pain | 49.78 | 12.10 | 197 | 23904 | 235783 | 64238848 |
Emotional distress | 47.72 | 12.10 | 63 | 24038 | 35975 | 64438656 |
Angina unstable | 47.11 | 12.10 | 42 | 24059 | 15425 | 64459206 |
Injury | 45.63 | 12.10 | 78 | 24023 | 55914 | 64418717 |
Carotid artery stenosis | 42.39 | 12.10 | 30 | 24071 | 7911 | 64466720 |
Swollen tongue | 41.57 | 12.10 | 58 | 24043 | 34896 | 64439735 |
Product complaint | 41.54 | 12.10 | 35 | 24066 | 11919 | 64462712 |
Cardiac disorder | 40.63 | 12.10 | 74 | 24027 | 55742 | 64418889 |
Blood pressure inadequately controlled | 37.52 | 12.10 | 24 | 24077 | 5360 | 64469271 |
Cardiovascular disorder | 36.67 | 12.10 | 37 | 24064 | 15844 | 64458787 |
Arteriosclerosis | 33.07 | 12.10 | 35 | 24066 | 15842 | 64458789 |
Drug abuse | 33.05 | 12.10 | 5 | 24096 | 132369 | 64342262 |
Drug intolerance | 32.15 | 12.10 | 15 | 24086 | 187977 | 64286654 |
Renal failure | 31.54 | 12.10 | 143 | 23958 | 181545 | 64293086 |
Mitral valve incompetence | 31.30 | 12.10 | 43 | 24058 | 25495 | 64449136 |
Drug ineffective | 30.93 | 12.10 | 186 | 23915 | 840061 | 63634570 |
Depression | 30.88 | 12.10 | 143 | 23958 | 183148 | 64291483 |
Contraindicated product administered | 29.53 | 12.10 | 3 | 24098 | 107826 | 64366805 |
Neutropenia | 29.07 | 12.10 | 28 | 24073 | 239596 | 64235035 |
Hyperlipidaemia | 28.63 | 12.10 | 39 | 24062 | 22937 | 64451694 |
Acute myocardial infarction | 28.32 | 12.10 | 73 | 24028 | 69645 | 64404986 |
Fear | 27.85 | 12.10 | 36 | 24065 | 20135 | 64454496 |
Dizziness | 26.96 | 12.10 | 262 | 23839 | 429901 | 64044730 |
Peripheral vascular disorder | 26.77 | 12.10 | 22 | 24079 | 7239 | 64467392 |
Maternal exposure during pregnancy | 25.41 | 12.10 | 3 | 24098 | 95881 | 64378750 |
Pyrexia | 25.37 | 12.10 | 115 | 23986 | 558529 | 63916102 |
Arteriosclerosis coronary artery | 25.10 | 12.10 | 30 | 24071 | 15499 | 64459132 |
Vasodilatation | 24.95 | 12.10 | 15 | 24086 | 3003 | 64471628 |
Blood pressure increased | 24.33 | 12.10 | 128 | 23973 | 172424 | 64302207 |
Infusion related reaction | 23.97 | 12.10 | 16 | 24085 | 164451 | 64310180 |
Treatment failure | 23.87 | 12.10 | 7 | 24094 | 116809 | 64357822 |
Renal injury | 23.62 | 12.10 | 29 | 24072 | 15400 | 64459231 |
Product use in unapproved indication | 23.38 | 12.10 | 19 | 24082 | 176599 | 64298032 |
Tricuspid valve incompetence | 22.93 | 12.10 | 30 | 24071 | 16973 | 64457658 |
Anxiety | 22.47 | 12.10 | 141 | 23960 | 202508 | 64272123 |
Blood glucose increased | 22.37 | 12.10 | 84 | 24017 | 97989 | 64376642 |
Shock | 22.09 | 12.10 | 46 | 24055 | 38194 | 64436437 |
Lacunar infarction | 20.89 | 12.10 | 17 | 24084 | 5515 | 64469116 |
Ventricular hypertrophy | 20.45 | 12.10 | 18 | 24083 | 6498 | 64468133 |
Kounis syndrome | 19.89 | 12.10 | 13 | 24088 | 3012 | 64471619 |
Exposure during pregnancy | 19.23 | 12.10 | 3 | 24098 | 77672 | 64396959 |
Rheumatoid arthritis | 19.00 | 12.10 | 20 | 24081 | 164274 | 64310357 |
C-reactive protein increased | 18.82 | 12.10 | 6 | 24095 | 94903 | 64379728 |
Palpitations | 18.68 | 12.10 | 83 | 24018 | 104405 | 64370226 |
Drug interaction | 18.60 | 12.10 | 71 | 24030 | 362012 | 64112619 |
Oropharyngeal swelling | 18.51 | 12.10 | 9 | 24092 | 1182 | 64473449 |
Laryngeal pain | 18.48 | 12.10 | 16 | 24085 | 5652 | 64468979 |
Pancytopenia | 18.25 | 12.10 | 16 | 24085 | 143293 | 64331338 |
Anhedonia | 18.20 | 12.10 | 24 | 24077 | 13682 | 64460949 |
Gastrooesophageal reflux disease | 17.96 | 12.10 | 70 | 24031 | 83073 | 64391558 |
Coronary artery occlusion | 17.95 | 12.10 | 24 | 24077 | 13867 | 64460764 |
Oedema peripheral | 17.80 | 12.10 | 137 | 23964 | 210180 | 64264451 |
Nodular rash | 17.61 | 12.10 | 6 | 24095 | 314 | 64474317 |
Lymphomatoid papulosis | 17.51 | 12.10 | 6 | 24095 | 320 | 64474311 |
Reaction to excipient | 17.11 | 12.10 | 9 | 24092 | 1394 | 64473237 |
Cardiomegaly | 16.72 | 12.10 | 31 | 24070 | 23653 | 64450978 |
Asthenia | 16.66 | 12.10 | 238 | 23863 | 427806 | 64046825 |
Unevaluable event | 16.65 | 12.10 | 49 | 24052 | 50440 | 64424191 |
Pancreatitis | 16.12 | 12.10 | 54 | 24047 | 59553 | 64415078 |
Myocardial ischaemia | 15.88 | 12.10 | 30 | 24071 | 23221 | 64451410 |
Completed suicide | 15.68 | 12.10 | 140 | 23961 | 224274 | 64250357 |
Febrile neutropenia | 15.55 | 12.10 | 29 | 24072 | 187628 | 64287003 |
Hypertensive heart disease | 15.02 | 12.10 | 12 | 24089 | 3792 | 64470839 |
Gastrointestinal haemorrhage | 14.61 | 12.10 | 92 | 24009 | 132220 | 64342411 |
Swelling face | 14.60 | 12.10 | 52 | 24049 | 59114 | 64415517 |
Hyperdynamic left ventricle | 14.25 | 12.10 | 5 | 24096 | 286 | 64474345 |
Atrial fibrillation | 14.22 | 12.10 | 111 | 23990 | 170978 | 64303653 |
Type 2 diabetes mellitus | 14.20 | 12.10 | 36 | 24065 | 33984 | 64440647 |
Ischaemic cardiomyopathy | 14.11 | 12.10 | 15 | 24086 | 6823 | 64467808 |
Electrocardiogram QT prolonged | 14.11 | 12.10 | 6 | 24095 | 79442 | 64395189 |
Gastritis | 13.71 | 12.10 | 41 | 24060 | 42577 | 64432054 |
Systemic lupus erythematosus | 13.56 | 12.10 | 6 | 24095 | 77606 | 64397025 |
Joint swelling | 13.26 | 12.10 | 39 | 24062 | 215343 | 64259288 |
Wound | 13.22 | 12.10 | 6 | 24095 | 76471 | 64398160 |
Urinary tract stoma complication | 13.15 | 12.10 | 3 | 24098 | 34 | 64474597 |
Tendon rupture | 13.00 | 12.10 | 18 | 24083 | 10749 | 64463882 |
Neck injury | 12.94 | 12.10 | 9 | 24092 | 2309 | 64472322 |
Blood urea increased | 12.83 | 12.10 | 41 | 24060 | 44112 | 64430519 |
Thrombocytopenia | 12.74 | 12.10 | 42 | 24059 | 223759 | 64250872 |
Therapeutic product effect incomplete | 12.64 | 12.10 | 12 | 24089 | 103470 | 64371161 |
General physical health deterioration | 12.60 | 12.10 | 37 | 24064 | 204388 | 64270243 |
Lip swelling | 12.53 | 12.10 | 33 | 24068 | 31874 | 64442757 |
Pericarditis | 12.31 | 12.10 | 4 | 24097 | 62512 | 64412119 |
Rhabdomyolysis | 12.21 | 12.10 | 67 | 24034 | 91659 | 64382972 |
Coronary artery surgery | 12.16 | 12.10 | 4 | 24097 | 188 | 64474443 |
None
Source | Code | Description |
---|---|---|
ATC | C09AA07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
ATC | C09BA07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics |
FDA MoA | N0000000181 | Angiotensin-converting Enzyme Inhibitors |
FDA EPC | N0000175562 | Angiotensin Converting Enzyme Inhibitor |
CHEBI has role | CHEBI:35457 | ACE inhibitor |
CHEBI has role | CHEBI:50266 | Prodrugs |
MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D011480 | Protease Inhibitors |
FDA PE | N0000178477 | Decreased Blood Pressure |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | off-label use | 48447003 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Diabetic renal disease | off-label use | 127013003 | |
Acute scleroderma renal crisis | off-label use | 236503001 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Hypertension due to Scleroderma | off-label use | ||
Nondiabetic Proteinuric Nephropathy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Jaundice | contraindication | 18165001 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Hepatic failure | contraindication | 59927004 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Azotemia | contraindication | 445009001 | |
Intestinal Angioedema | contraindication | ||
Head and Neck Angioedema | contraindication | ||
Hemodialysis with High-Flux Membrane | contraindication | ||
Severe Aortic Valve Stenosis | contraindication |
None
Product | Applicant | Ingredients |
---|---|---|
Cardalis | Ceva Sante Animale | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.9 | acidic |
pKa2 | 5.34 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 6.51 | WOMBAT-PK | CHEMBL | |||
Angiotensin-converting enzyme | Enzyme | IC50 | 8.70 | CHEMBL | |||||
Angiotensin-converting enzyme | Enzyme | IC50 | 8.77 | CHEMBL |
ID | Source |
---|---|
4020817 | VUID |
N0000148336 | NUI |
D00620 | KEGG_DRUG |
86541-74-4 | SECONDARY_CAS_RN |
1546196 | RXNORM |
C0053091 | UMLSCUI |
CHEBI:3011 | CHEBI |
CHEBI:88200 | CHEBI |
CHEMBL838 | ChEMBL_ID |
CHEMBL1694 | ChEMBL_ID |
DB00542 | DRUGBANK_ID |
C044946 | MESH_SUPPLEMENTAL_RECORD_UI |
5362124 | PUBCHEM_CID |
6374 | IUPHAR_LIGAND_ID |
C052133 | MESH_SUPPLEMENTAL_RECORD_UI |
6375 | IUPHAR_LIGAND_ID |
6129 | INN_ID |
86541-78-8 | SECONDARY_CAS_RN |
UDM7Q7QWP8 | UNII |
5463984 | PUBCHEM_CID |
DB14125 | DRUGBANK_ID |
1267 | MMSL |
4251 | MMSL |
48720 | MMSL |
d00730 | MMSL |
003597 | NDDF |
003598 | NDDF |
4020025 | VANDF |
4020817 | VANDF |
C0105523 | UMLSCUI |
CHEMBL1192519 | ChEMBL_ID |
6128 | INN_ID |
108572003 | SNOMEDCT_US |
108573008 | SNOMEDCT_US |
372511001 | SNOMEDCT_US |
JRM708L703 | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0364 | CAPSULE | 20 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0364 | CAPSULE | 20 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0379 | CAPSULE | 40 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0379 | CAPSULE | 40 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0405 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0405 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0406 | CAPSULE | 20 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0406 | CAPSULE | 20 mg | ORAL | NDA | 31 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0211 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0211 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0236 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0236 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0277 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0277 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0325 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0325 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 22 sections |
benazepril hydrochloride and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0574-0227 | TABLET | 10 mg | ORAL | NDA authorized generic | 23 sections |
benazepril hydrochloride and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0574-0228 | TABLET | 20 mg | ORAL | NDA authorized generic | 23 sections |
benazepril hydrochloride and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0574-0229 | TABLET | 20 mg | ORAL | NDA authorized generic | 23 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-554 | TABLET | 20 mg | ORAL | ANDA | 13 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-561 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 13 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-566 | TABLET | 10 mg | ORAL | ANDA | 13 sections |
BENAZEPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-259 | TABLET | 20 mg | ORAL | ANDA | 13 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-280 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-327 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 19 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-612 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 19 sections |
Amlobenz | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-866 | CAPSULE | 10 mg | ORAL | ANDA | 27 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-877 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 19 sections |
Amlobenz | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-916 | CAPSULE | 20 mg | ORAL | ANDA | 27 sections |
Lotensin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 30698-448 | TABLET | 10 mg | ORAL | NDA | 26 sections |