Stem definition | Drug id | CAS RN |
---|---|---|
angiotensin-converting enzyme inhibitors | 299 | 86541-75-5 |
Dose | Unit | Route |
---|---|---|
7.50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 78 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.13 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 18 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
June 25, 1991 | FDA | US PHARMS HOLDINGS I |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 141.67 | 12.87 | 111 | 17302 | 41342 | 56233312 |
Cerebrovascular accident | 125.46 | 12.87 | 154 | 17259 | 99116 | 56175538 |
Myocardial infarction | 112.41 | 12.87 | 141 | 17272 | 92729 | 56181925 |
Coronary artery disease | 110.72 | 12.87 | 85 | 17328 | 30711 | 56243943 |
Cardiac failure congestive | 102.69 | 12.87 | 131 | 17282 | 87589 | 56187065 |
Off label use | 61.94 | 12.87 | 49 | 17364 | 556131 | 55718523 |
Drug ineffective | 54.05 | 12.87 | 129 | 17284 | 918860 | 55355794 |
Maternal exposure during pregnancy | 43.98 | 12.87 | 4 | 17409 | 189549 | 56085105 |
Transient ischaemic attack | 43.82 | 12.87 | 53 | 17360 | 33524 | 56241130 |
Rheumatoid arthritis | 43.42 | 12.87 | 33 | 17380 | 382571 | 55892083 |
Contraindicated product administered | 43.04 | 12.87 | 4 | 17409 | 186282 | 56088372 |
Chest pain | 42.33 | 12.87 | 142 | 17271 | 189655 | 56084999 |
Drug intolerance | 39.91 | 12.87 | 16 | 17397 | 264802 | 56009852 |
Dizziness | 37.45 | 12.87 | 221 | 17192 | 375919 | 55898735 |
Blood pressure inadequately controlled | 37.29 | 12.87 | 21 | 17392 | 4503 | 56270151 |
Treatment failure | 36.00 | 12.87 | 5 | 17408 | 170387 | 56104267 |
Swollen tongue | 34.98 | 12.87 | 45 | 17368 | 30279 | 56244375 |
Mitral valve incompetence | 32.87 | 12.87 | 34 | 17379 | 18119 | 56256535 |
Infusion related reaction | 32.50 | 12.87 | 12 | 17401 | 208919 | 56065735 |
Renal failure | 32.38 | 12.87 | 91 | 17322 | 110409 | 56164245 |
Systemic lupus erythematosus | 32.25 | 12.87 | 8 | 17405 | 180070 | 56094584 |
Vasodilatation | 31.32 | 12.87 | 15 | 17398 | 2306 | 56272348 |
Glossodynia | 30.99 | 12.87 | 5 | 17408 | 152453 | 56122201 |
Product complaint | 30.77 | 12.87 | 27 | 17386 | 11733 | 56262921 |
Carotid artery stenosis | 30.53 | 12.87 | 19 | 17394 | 4891 | 56269763 |
Oropharyngeal swelling | 30.08 | 12.87 | 11 | 17402 | 860 | 56273794 |
Oedema peripheral | 29.60 | 12.87 | 118 | 17295 | 171136 | 56103518 |
Arteriosclerosis | 29.46 | 12.87 | 24 | 17389 | 9429 | 56265225 |
Angina unstable | 29.38 | 12.87 | 21 | 17392 | 6800 | 56267854 |
Rhabdomyolysis | 28.90 | 12.87 | 48 | 17365 | 40610 | 56234044 |
Renal tubular atrophy | 27.99 | 12.87 | 10 | 17403 | 731 | 56273923 |
Completed suicide | 26.23 | 12.87 | 96 | 17317 | 133737 | 56140917 |
Kounis syndrome | 25.82 | 12.87 | 11 | 17402 | 1287 | 56273367 |
Wound | 25.17 | 12.87 | 6 | 17407 | 138798 | 56135856 |
Nephrosclerosis | 25.11 | 12.87 | 10 | 17403 | 986 | 56273668 |
Emotional distress | 25.10 | 12.87 | 38 | 17375 | 29725 | 56244929 |
Cardiac disorder | 24.71 | 12.87 | 48 | 17365 | 45839 | 56228815 |
Cardiovascular disorder | 24.56 | 12.87 | 23 | 17390 | 10866 | 56263788 |
Exposure during pregnancy | 24.51 | 12.87 | 6 | 17407 | 136336 | 56138318 |
Tricuspid valve incompetence | 22.52 | 12.87 | 24 | 17389 | 13229 | 56261425 |
Renal injury | 22.45 | 12.87 | 20 | 17393 | 8867 | 56265787 |
Hypertension | 20.79 | 12.87 | 138 | 17275 | 244140 | 56030514 |
Arteriosclerosis coronary artery | 20.58 | 12.87 | 18 | 17395 | 7787 | 56266867 |
Kidney fibrosis | 19.75 | 12.87 | 10 | 17403 | 1732 | 56272922 |
Blood pressure increased | 19.68 | 12.87 | 93 | 17320 | 145083 | 56129571 |
Dehydration | 19.57 | 12.87 | 99 | 17314 | 158726 | 56115928 |
Reaction to excipient | 19.49 | 12.87 | 9 | 17404 | 1275 | 56273379 |
Depression | 19.28 | 12.87 | 108 | 17305 | 180009 | 56094645 |
Swelling face | 19.26 | 12.87 | 49 | 17364 | 56020 | 56218634 |
Injury | 19.22 | 12.87 | 51 | 17362 | 59800 | 56214854 |
Pericarditis | 19.18 | 12.87 | 5 | 17408 | 108918 | 56165736 |
Gastrooesophageal reflux disease | 19.15 | 12.87 | 63 | 17350 | 83194 | 56191460 |
Palpitations | 19.10 | 12.87 | 71 | 17342 | 99601 | 56175053 |
Gastrointestinal haemorrhage | 18.86 | 12.87 | 59 | 17354 | 75892 | 56198762 |
Fear | 18.58 | 12.87 | 23 | 17390 | 14885 | 56259769 |
Hyperdynamic left ventricle | 17.60 | 12.87 | 5 | 17408 | 173 | 56274481 |
Joint swelling | 17.44 | 12.87 | 40 | 17373 | 289760 | 55984894 |
Coronary artery occlusion | 16.81 | 12.87 | 16 | 17397 | 7713 | 56266941 |
Keratoacanthoma | 16.70 | 12.87 | 6 | 17407 | 446 | 56274208 |
Vasoplegia syndrome | 16.18 | 12.87 | 8 | 17405 | 1317 | 56273337 |
Blood glucose increased | 15.64 | 12.87 | 55 | 17358 | 75096 | 56199558 |
Product use issue | 15.42 | 12.87 | 21 | 17392 | 186020 | 56088634 |
Therapeutic product effect decreased | 15.21 | 12.87 | 18 | 17395 | 169434 | 56105220 |
Tendon rupture | 15.20 | 12.87 | 15 | 17398 | 7555 | 56267099 |
C-reactive protein increased | 15.07 | 12.87 | 3 | 17410 | 78681 | 56195973 |
Blood urea increased | 14.91 | 12.87 | 27 | 17386 | 24446 | 56250208 |
Pyrexia | 14.77 | 12.87 | 73 | 17340 | 418700 | 55855954 |
Peripheral vascular disorder | 14.69 | 12.87 | 13 | 17400 | 5712 | 56268942 |
Cardiomegaly | 13.85 | 12.87 | 21 | 17392 | 16446 | 56258208 |
Rhinitis allergic | 13.79 | 12.87 | 15 | 17398 | 8459 | 56266195 |
Laryngeal pain | 13.75 | 12.87 | 11 | 17402 | 4209 | 56270445 |
Hyperlipidaemia | 13.71 | 12.87 | 22 | 17391 | 18087 | 56256567 |
Hiatus hernia | 13.69 | 12.87 | 23 | 17390 | 19629 | 56255025 |
Tubulointerstitial nephritis | 13.66 | 12.87 | 21 | 17392 | 16644 | 56258010 |
Anxiety | 13.44 | 12.87 | 104 | 17309 | 193068 | 56081586 |
Haemorrhoids | 13.22 | 12.87 | 23 | 17390 | 20183 | 56254471 |
Asthenia | 13.18 | 12.87 | 163 | 17250 | 342810 | 55931844 |
Muscle spasms | 13.15 | 12.87 | 80 | 17333 | 137291 | 56137363 |
Mental status changes | 13.11 | 12.87 | 33 | 17380 | 37468 | 56237186 |
Alopecia | 12.89 | 12.87 | 47 | 17366 | 293411 | 55981243 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 198.59 | 13.07 | 143 | 13614 | 33475 | 31650112 |
Myocardial infarction | 127.58 | 13.07 | 198 | 13559 | 113256 | 31570331 |
Coronary artery disease | 102.98 | 13.07 | 113 | 13644 | 45974 | 31637613 |
Cardiac failure congestive | 73.44 | 13.07 | 127 | 13630 | 79260 | 31604327 |
Cerebrovascular accident | 69.44 | 13.07 | 124 | 13633 | 79360 | 31604227 |
Off label use | 54.21 | 13.07 | 43 | 13714 | 347231 | 31336356 |
Injury | 33.43 | 13.07 | 42 | 13715 | 19667 | 31663920 |
Swollen tongue | 29.48 | 13.07 | 32 | 13725 | 12830 | 31670757 |
Chest pain | 27.53 | 13.07 | 112 | 13645 | 116845 | 31566742 |
Product complaint | 26.98 | 13.07 | 21 | 13736 | 5503 | 31678084 |
Emotional distress | 26.62 | 13.07 | 32 | 13725 | 14324 | 31669263 |
Blood glucose increased | 26.52 | 13.07 | 72 | 13685 | 61011 | 31622576 |
Nodular rash | 23.05 | 13.07 | 6 | 13751 | 104 | 31683483 |
Lymphomatoid papulosis | 19.50 | 13.07 | 6 | 13751 | 194 | 31683393 |
Asthenia | 18.39 | 13.07 | 163 | 13594 | 224592 | 31458995 |
Blood pressure inadequately controlled | 18.07 | 13.07 | 12 | 13745 | 2457 | 31681130 |
Neutropenia | 17.61 | 13.07 | 21 | 13736 | 140343 | 31543244 |
Pancreatitis | 17.39 | 13.07 | 44 | 13713 | 35727 | 31647860 |
Carotid artery stenosis | 17.11 | 13.07 | 15 | 13742 | 4637 | 31678950 |
Blood gases abnormal | 17.02 | 13.07 | 6 | 13751 | 299 | 31683288 |
Shock | 16.82 | 13.07 | 33 | 13724 | 22612 | 31660975 |
Hyperlipidaemia | 16.18 | 13.07 | 24 | 13733 | 13136 | 31670451 |
Depression | 16.11 | 13.07 | 80 | 13677 | 90735 | 31592852 |
Angina unstable | 16.10 | 13.07 | 22 | 13735 | 11173 | 31672414 |
Lip swelling | 15.95 | 13.07 | 24 | 13733 | 13299 | 31670288 |
Product use in unapproved indication | 15.75 | 13.07 | 12 | 13745 | 99159 | 31584428 |
Acute myocardial infarction | 15.55 | 13.07 | 53 | 13704 | 50770 | 31632817 |
Dizziness | 15.55 | 13.07 | 143 | 13614 | 199004 | 31484583 |
General physical health deterioration | 15.29 | 13.07 | 16 | 13741 | 113419 | 31570168 |
Nephrogenic systemic fibrosis | 15.04 | 13.07 | 13 | 13744 | 3942 | 31679645 |
Fear | 14.95 | 13.07 | 20 | 13737 | 9954 | 31673633 |
Anxiety | 14.62 | 13.07 | 78 | 13679 | 90955 | 31592632 |
Cardiovascular disorder | 14.35 | 13.07 | 19 | 13738 | 9359 | 31674228 |
Pharyngeal oedema | 14.31 | 13.07 | 15 | 13742 | 5781 | 31677806 |
Transient ischaemic attack | 14.30 | 13.07 | 32 | 13725 | 24024 | 31659563 |
Drug interaction | 14.14 | 13.07 | 45 | 13712 | 208498 | 31475089 |
Type 2 diabetes mellitus | 14.09 | 13.07 | 24 | 13733 | 14760 | 31668827 |
Lacunar infarction | 13.98 | 13.07 | 11 | 13746 | 2929 | 31680658 |
Toxicity to various agents | 13.88 | 13.07 | 37 | 13720 | 181450 | 31502137 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angioedema | 290.87 | 12.58 | 216 | 24362 | 66394 | 70837472 |
Myocardial infarction | 247.74 | 12.58 | 301 | 24277 | 171344 | 70732522 |
Coronary artery disease | 229.13 | 12.58 | 183 | 24395 | 62553 | 70841313 |
Cerebrovascular accident | 188.30 | 12.58 | 240 | 24338 | 143230 | 70760636 |
Cardiac failure congestive | 152.12 | 12.58 | 210 | 24368 | 135247 | 70768619 |
Off label use | 99.68 | 12.58 | 68 | 24510 | 742992 | 70160874 |
Transient ischaemic attack | 54.16 | 12.58 | 73 | 24505 | 45871 | 70857995 |
Chest pain | 52.82 | 12.58 | 199 | 24379 | 251061 | 70652805 |
Emotional distress | 49.92 | 12.58 | 63 | 24515 | 37125 | 70866741 |
Angina unstable | 48.86 | 12.58 | 42 | 24536 | 15851 | 70888015 |
Rheumatoid arthritis | 47.24 | 12.58 | 21 | 24557 | 291784 | 70612082 |
Carotid artery stenosis | 43.44 | 12.58 | 30 | 24548 | 8206 | 70895660 |
Product complaint | 43.15 | 12.58 | 35 | 24543 | 12196 | 70891670 |
Swollen tongue | 42.35 | 12.58 | 58 | 24520 | 36988 | 70866878 |
Cardiac disorder | 41.32 | 12.58 | 74 | 24504 | 59341 | 70844525 |
Injury | 41.27 | 12.58 | 78 | 24500 | 65167 | 70838699 |
Drug intolerance | 38.52 | 12.58 | 15 | 24563 | 225672 | 70678194 |
Blood pressure inadequately controlled | 38.35 | 12.58 | 24 | 24554 | 5568 | 70898298 |
Cardiovascular disorder | 37.51 | 12.58 | 37 | 24541 | 16633 | 70887233 |
Drug ineffective | 34.75 | 12.58 | 188 | 24390 | 939564 | 69964302 |
Drug abuse | 34.46 | 12.58 | 5 | 24573 | 147251 | 70756615 |
Renal failure | 34.26 | 12.58 | 143 | 24435 | 188927 | 70714939 |
Arteriosclerosis | 33.91 | 12.58 | 35 | 24543 | 16603 | 70887263 |
Contraindicated product administered | 32.86 | 12.58 | 4 | 24574 | 134608 | 70769258 |
Mitral valve incompetence | 32.30 | 12.58 | 43 | 24535 | 26685 | 70877181 |
Depression | 30.38 | 12.58 | 143 | 24435 | 198831 | 70705035 |
Dizziness | 29.92 | 12.58 | 268 | 24310 | 463873 | 70439993 |
Acute myocardial infarction | 29.78 | 12.58 | 73 | 24505 | 72814 | 70831052 |
Hyperlipidaemia | 29.78 | 12.58 | 39 | 24539 | 23824 | 70880042 |
Treatment failure | 29.23 | 12.58 | 7 | 24571 | 144135 | 70759731 |
Fear | 29.11 | 12.58 | 36 | 24542 | 20775 | 70883091 |
Neutropenia | 28.77 | 12.58 | 28 | 24550 | 257128 | 70646738 |
Infusion related reaction | 27.82 | 12.58 | 17 | 24561 | 197517 | 70706349 |
Arteriosclerosis coronary artery | 27.58 | 12.58 | 31 | 24547 | 16184 | 70887682 |
Peripheral vascular disorder | 27.26 | 12.58 | 22 | 24556 | 7610 | 70896256 |
Maternal exposure during pregnancy | 26.79 | 12.58 | 4 | 24574 | 115341 | 70788525 |
Vasodilatation | 25.68 | 12.58 | 15 | 24563 | 3073 | 70900793 |
Blood pressure increased | 25.57 | 12.58 | 131 | 24447 | 188386 | 70715480 |
Pyrexia | 24.88 | 12.58 | 117 | 24461 | 606835 | 70297031 |
Renal injury | 24.40 | 12.58 | 29 | 24549 | 16065 | 70887801 |
Hypertension | 23.92 | 12.58 | 180 | 24398 | 295853 | 70608013 |
Blood glucose increased | 23.64 | 12.58 | 84 | 24494 | 102898 | 70800968 |
Tricuspid valve incompetence | 23.61 | 12.58 | 30 | 24548 | 17787 | 70886079 |
Anxiety | 23.18 | 12.58 | 143 | 24435 | 220187 | 70683679 |
Shock | 22.72 | 12.58 | 46 | 24532 | 40379 | 70863487 |
Nephrosclerosis | 21.66 | 12.58 | 11 | 24567 | 1710 | 70902156 |
Product use in unapproved indication | 21.61 | 12.58 | 24 | 24554 | 207454 | 70696412 |
Lacunar infarction | 21.58 | 12.58 | 17 | 24561 | 5679 | 70898187 |
Ventricular hypertrophy | 21.47 | 12.58 | 18 | 24560 | 6566 | 70897300 |
C-reactive protein increased | 21.20 | 12.58 | 6 | 24572 | 110511 | 70793355 |
Exposure during pregnancy | 20.46 | 12.58 | 3 | 24575 | 87714 | 70816152 |
Palpitations | 20.22 | 12.58 | 84 | 24494 | 110669 | 70793197 |
Completed suicide | 19.41 | 12.58 | 140 | 24438 | 226995 | 70676871 |
Laryngeal pain | 19.38 | 12.58 | 16 | 24562 | 5712 | 70898154 |
Kounis syndrome | 19.36 | 12.58 | 13 | 24565 | 3398 | 70900468 |
Asthenia | 19.01 | 12.58 | 242 | 24336 | 457424 | 70446442 |
Anhedonia | 18.94 | 12.58 | 24 | 24554 | 14189 | 70889677 |
Coronary artery occlusion | 18.77 | 12.58 | 24 | 24554 | 14321 | 70889545 |
Oropharyngeal swelling | 18.73 | 12.58 | 9 | 24569 | 1243 | 70902623 |
Systemic lupus erythematosus | 18.69 | 12.58 | 6 | 24572 | 101896 | 70801970 |
Renal tubular atrophy | 18.68 | 12.58 | 10 | 24568 | 1732 | 70902134 |
Rhabdomyolysis | 18.57 | 12.58 | 74 | 24504 | 95686 | 70808180 |
Nodular rash | 18.06 | 12.58 | 6 | 24572 | 314 | 70903552 |
Unevaluable event | 18.02 | 12.58 | 49 | 24529 | 52014 | 70851852 |
Oedema peripheral | 18.02 | 12.58 | 138 | 24440 | 227953 | 70675913 |
Wound | 17.78 | 12.58 | 6 | 24572 | 98726 | 70805140 |
Lymphomatoid papulosis | 17.67 | 12.58 | 6 | 24572 | 336 | 70903530 |
Cardiomegaly | 17.61 | 12.58 | 31 | 24547 | 24514 | 70879352 |
Gastrooesophageal reflux disease | 17.45 | 12.58 | 70 | 24508 | 90769 | 70813097 |
Reaction to excipient | 17.43 | 12.58 | 9 | 24569 | 1449 | 70902417 |
Pancytopenia | 17.42 | 12.58 | 16 | 24562 | 151091 | 70752775 |
Pericarditis | 17.39 | 12.58 | 4 | 24574 | 84701 | 70819165 |
Joint swelling | 17.17 | 12.58 | 39 | 24539 | 253172 | 70650694 |
Pancreatitis | 16.93 | 12.58 | 54 | 24524 | 62614 | 70841252 |
Myocardial ischaemia | 16.64 | 12.58 | 30 | 24548 | 24170 | 70879696 |
Gastrointestinal haemorrhage | 16.25 | 12.58 | 92 | 24486 | 137316 | 70766550 |
Febrile neutropenia | 15.95 | 12.58 | 29 | 24549 | 204289 | 70699577 |
Hypertensive heart disease | 15.52 | 12.58 | 12 | 24566 | 3904 | 70899962 |
Gastritis | 15.46 | 12.58 | 42 | 24536 | 44549 | 70859317 |
Atrial fibrillation | 15.38 | 12.58 | 113 | 24465 | 184235 | 70719631 |
Swelling face | 14.90 | 12.58 | 52 | 24526 | 63112 | 70840754 |
Drug interaction | 14.74 | 12.58 | 75 | 24503 | 381366 | 70522500 |
Ischaemic cardiomyopathy | 14.57 | 12.58 | 15 | 24563 | 7089 | 70896777 |
Product use issue | 14.53 | 12.58 | 25 | 24553 | 179912 | 70723954 |
Musculoskeletal stiffness | 14.41 | 12.58 | 18 | 24560 | 147742 | 70756124 |
General physical health deterioration | 13.94 | 12.58 | 39 | 24539 | 235992 | 70667874 |
Blood urea increased | 13.74 | 12.58 | 41 | 24537 | 45868 | 70857998 |
Tendon rupture | 13.54 | 12.58 | 18 | 24560 | 11151 | 70892715 |
Electrocardiogram QT prolonged | 13.51 | 12.58 | 6 | 24572 | 83511 | 70820355 |
Therapeutic product effect incomplete | 13.46 | 12.58 | 13 | 24565 | 119869 | 70783997 |
Cerebral infarction | 13.43 | 12.58 | 39 | 24539 | 42970 | 70860896 |
Hyperdynamic left ventricle | 13.41 | 12.58 | 5 | 24573 | 368 | 70903498 |
Neck injury | 13.10 | 12.58 | 9 | 24569 | 2441 | 70901425 |
Kidney fibrosis | 12.83 | 12.58 | 10 | 24568 | 3290 | 70900576 |
Pharyngeal oedema | 12.81 | 12.58 | 21 | 24557 | 15675 | 70888191 |
Lip swelling | 12.75 | 12.58 | 33 | 24545 | 34021 | 70869845 |
None
Source | Code | Description |
---|---|---|
ATC | C09AA07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
ATC | C09BA07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics |
FDA MoA | N0000000181 | Angiotensin-converting Enzyme Inhibitors |
FDA EPC | N0000175562 | Angiotensin Converting Enzyme Inhibitor |
CHEBI has role | CHEBI:35457 | ACE inhibitor |
CHEBI has role | CHEBI:50266 | Prodrugs |
MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D011480 | Protease Inhibitors |
FDA PE | N0000178477 | Decreased Blood Pressure |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | off-label use | 48447003 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Diabetic renal disease | off-label use | 127013003 | |
Acute scleroderma renal crisis | off-label use | 236503001 | |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Hypertension due to Scleroderma | off-label use | ||
Nondiabetic Proteinuric Nephropathy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Jaundice | contraindication | 18165001 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Hepatic failure | contraindication | 59927004 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Azotemia | contraindication | 445009001 | |
Intestinal Angioedema | contraindication | ||
Head and Neck Angioedema | contraindication | ||
Hemodialysis with High-Flux Membrane | contraindication | ||
Severe Aortic Valve Stenosis | contraindication |
None
Product | Applicant | Ingredients |
---|---|---|
Cardalis | Ceva Sante Animale | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.9 | acidic |
pKa2 | 5.34 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 6.51 | WOMBAT-PK | CHEMBL | |||
Angiotensin-converting enzyme | Enzyme | IC50 | 8.70 | CHEMBL | |||||
Angiotensin-converting enzyme | Enzyme | IC50 | 8.77 | CHEMBL |
ID | Source |
---|---|
4020817 | VUID |
N0000148336 | NUI |
D00620 | KEGG_DRUG |
86541-74-4 | SECONDARY_CAS_RN |
1546196 | RXNORM |
4020025 | VANDF |
4020817 | VANDF |
C0053091 | UMLSCUI |
CHEBI:3011 | CHEBI |
CHEBI:88200 | CHEBI |
CHEMBL838 | ChEMBL_ID |
CHEMBL1694 | ChEMBL_ID |
DB00542 | DRUGBANK_ID |
C044946 | MESH_SUPPLEMENTAL_RECORD_UI |
5362124 | PUBCHEM_CID |
6374 | IUPHAR_LIGAND_ID |
C052133 | MESH_SUPPLEMENTAL_RECORD_UI |
6375 | IUPHAR_LIGAND_ID |
6129 | INN_ID |
UDM7Q7QWP8 | UNII |
DB14125 | DRUGBANK_ID |
1267 | MMSL |
4251 | MMSL |
48720 | MMSL |
d00730 | MMSL |
003597 | NDDF |
003598 | NDDF |
108572003 | SNOMEDCT_US |
108573008 | SNOMEDCT_US |
372511001 | SNOMEDCT_US |
C0105523 | UMLSCUI |
CHEMBL1192519 | ChEMBL_ID |
6128 | INN_ID |
86541-78-8 | SECONDARY_CAS_RN |
5463984 | PUBCHEM_CID |
JRM708L703 | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0364 | CAPSULE | 20 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0364 | CAPSULE | 20 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0379 | CAPSULE | 40 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0379 | CAPSULE | 40 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0405 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0405 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0406 | CAPSULE | 20 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0406 | CAPSULE | 20 mg | ORAL | NDA | 31 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0211 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0211 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0211 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0236 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0236 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0236 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0277 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0277 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0277 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0325 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0325 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 22 sections |
Benazepril Hydrochloride and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0185-0325 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 22 sections |
benazepril hydrochloride and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0574-0227 | TABLET | 10 mg | ORAL | NDA authorized generic | 23 sections |
benazepril hydrochloride and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0574-0228 | TABLET | 20 mg | ORAL | NDA authorized generic | 23 sections |
benazepril hydrochloride and hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0574-0229 | TABLET | 20 mg | ORAL | NDA authorized generic | 23 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-554 | TABLET | 20 mg | ORAL | ANDA | 13 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-561 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 13 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-566 | TABLET | 10 mg | ORAL | ANDA | 13 sections |
BENAZEPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-259 | TABLET | 20 mg | ORAL | ANDA | 13 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-280 | TABLET | 10 mg | ORAL | ANDA | 12 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-327 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 19 sections |
Benazepril Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-612 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 19 sections |