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retinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
retinol derivatives	2831	68-26-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: vitamin A1 vitamin A retinol retinol (vit A)	Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. Molecular weight: 286.46 Formula: C20H30O CLOGP: 6.40 LIPINSKI: 1 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -4.58 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

vitamin A1
vitamin A
retinol
retinol (vit A)

Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.

Molecular weight: 286.46
Formula: C20H30O
CLOGP: 6.40
LIPINSKI: 1
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: -4.58
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
50	TU	O
50	TU	P
800	U	N

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.04 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	249.07	14.78	117	9250	32294	56250406
Coma	177.24	14.78	115	9252	59540	56223160
Gastrooesophageal reflux disease	173.40	14.78	129	9238	83128	56199572
Somnolence	130.73	14.78	148	9219	163265	56119435
Blood magnesium increased	127.82	14.78	38	9329	2913	56279787
Pleural thickening	126.42	14.78	37	9330	2686	56280014
Presbyacusis	120.56	14.78	36	9331	2802	56279898
Pleural fibrosis	117.69	14.78	37	9330	3422	56279278
Deafness neurosensory	110.44	14.78	38	9329	4660	56278040
Epigastric discomfort	96.27	14.78	37	9330	6211	56276489
Cyst	76.66	14.78	39	9328	12739	56269961
Osteopenia	63.88	14.78	39	9328	18102	56264598
Blood potassium increased	63.07	14.78	38	9329	17223	56265477
Skin lesion	57.12	14.78	43	9324	28092	56254608
Dry eye	52.12	14.78	45	9322	35671	56247029
Bone cyst	45.47	14.78	16	9351	2094	56280606
Osteosclerosis	36.91	14.78	16	9351	3647	56279053
Choanal stenosis	35.99	14.78	6	9361	27	56282673
Blood creatinine increased	34.92	14.78	54	9313	80137	56202563
Enterobacter infection	34.66	14.78	13	9354	2039	56280661
Underdose	32.78	14.78	29	9338	23728	56258972
Infective pulmonary exacerbation of cystic fibrosis	29.90	14.78	18	9349	8139	56274561
Granulomatous liver disease	29.71	14.78	9	9358	735	56281965
Osteoarthritis	28.10	14.78	49	9318	80247	56202453
Aorta hypoplasia	27.12	14.78	6	9361	139	56282561
Exostosis	24.20	14.78	20	9347	14923	56267777
Renal impairment	24.12	14.78	46	9321	80667	56202033
Osteochondritis	23.03	14.78	4	9363	24	56282676
Deformity	21.53	14.78	16	9351	10239	56272461
Bone hypertrophy	20.83	14.78	6	9361	411	56282289
Tracheo-oesophageal fistula	19.14	14.78	6	9361	549	56282151
Gastrointestinal disorder	18.83	14.78	51	9316	112651	56170049
Malabsorption	18.20	14.78	10	9357	3811	56278889
Sleep disorder	17.14	14.78	36	9331	67627	56215073
Hepatic cirrhosis	16.49	14.78	19	9348	21244	56261456
Anomaly of external ear congenital	15.77	14.78	4	9363	169	56282531
Hiatus hernia strangulated	15.77	14.78	4	9363	169	56282531
Oesophageal atresia	15.28	14.78	5	9362	525	56282175
Coarctation of the aorta	14.90	14.78	5	9362	568	56282132

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory tract infection bacterial	66.76	16.76	18	3532	1448	31692346
Respiratory tract infection viral	61.10	16.76	18	3532	1996	31691798
Infective pulmonary exacerbation of cystic fibrosis	53.83	16.76	22	3528	6462	31687332
Respiratory tract infection	33.15	16.76	22	3528	17539	31676255
Hypervitaminosis A	26.16	16.76	4	3546	15	31693779
Cytokine release syndrome	24.72	16.76	18	3532	16624	31677170
Ocular hyperaemia	17.59	16.76	12	3538	9997	31683797

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	191.15	13.62	118	10521	62171	70855634
Gastrooesophageal reflux disease	177.49	13.62	130	10509	90709	70827096
Coma	151.88	13.62	119	10520	91725	70826080
Somnolence	128.93	13.62	160	10479	215446	70702359
Presbyacusis	109.03	13.62	32	10607	2605	70915200
Pleural thickening	106.77	13.62	32	10607	2800	70915005
Blood magnesium increased	101.65	13.62	32	10607	3299	70914506
Pleural fibrosis	94.83	13.62	32	10607	4107	70913698
Deafness neurosensory	90.67	13.62	35	10604	6597	70911208
Epigastric discomfort	80.83	13.62	33	10606	7200	70910605
Infective pulmonary exacerbation of cystic fibrosis	73.26	13.62	36	10603	12122	70905683
Cyst	63.02	13.62	33	10606	12686	70905119
Respiratory tract infection bacterial	58.51	13.62	18	10621	1719	70916086
Dry eye	58.02	13.62	44	10595	32238	70885567
Osteopenia	57.23	13.62	34	10605	16663	70901142
Skin lesion	47.21	13.62	42	10597	38418	70879387
Respiratory tract infection viral	45.96	13.62	18	10621	3523	70914282
Bone cyst	42.27	13.62	16	10623	2858	70914947
Blood potassium increased	37.90	13.62	32	10607	27294	70890511
Hypervitaminosis A	36.43	13.62	6	10633	28	70917777
Osteosclerosis	35.00	13.62	15	10624	3690	70914115
Underdose	30.07	13.62	29	10610	29354	70888451
Deformity	26.12	13.62	16	10623	8281	70909524
Osteoarthritis	24.98	13.62	42	10597	74105	70843700
Enterobacter infection	24.39	13.62	12	10627	4048	70913757
Osteochondritis	23.03	13.62	4	10635	27	70917778
Granulomatous liver disease	22.33	13.62	8	10631	1224	70916581
Bone hypertrophy	22.08	13.62	6	10633	369	70917436
Cystic fibrosis	20.90	13.62	11	10628	4270	70913535
Exostosis	20.30	13.62	17	10622	14328	70903477
Sleep disorder	20.19	13.62	37	10602	69835	70847970
Treatment failure	18.03	13.62	55	10584	144087	70773718
Cytokine release syndrome	17.97	13.62	21	10618	26446	70891359
Completed suicide	17.69	13.62	6	10633	227129	70690676
Prealbumin decreased	17.22	13.62	4	10635	129	70917676
Breast cancer	17.00	13.62	23	10616	33526	70884279
Gastrointestinal disorder	16.88	13.62	44	10595	105383	70812422
Vitamin A decreased	16.51	13.62	3	10636	27	70917778
Hiatus hernia strangulated	16.18	13.62	4	10635	169	70917636
Hospitalisation	14.83	13.62	36	10603	82532	70835273
Blood creatinine increased	14.66	13.62	51	10588	142950	70774855
Oesophageal adenocarcinoma	13.63	13.62	5	10634	818	70916987

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11CA01	ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO Vitamin A, plain
ATC	D10AD02	DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Retinoids for topical use in acne
ATC	R01AX02	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Other nasal preparations
ATC	S01XA02	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
FDA CS	M0022788	Vitamin A
CHEBI has role	CHEBI:24020	fat-soluble vitamins
CHEBI has role	CHEBI:25212	metabolites
MeSH PA	D018977	Micronutrients
MeSH PA	D014815	Vitamins
FDA EPC	N0000175950	Vitamin A
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vitamin A deficiency	indication	72000004
Vitamin deficiency	indication	85670002
Mineral deficiency	indication	111379007
Prevention of dental caries	indication	426482000
Mineral Deficiency Prevention	indication
Vitamin Deficiency Prevention	indication
Diaper rash	off-label use	91487003
Abetalipoproteinemia	off-label use	190787008	DOID:1386
Skin irritation	off-label use	367466007
Peptic ulcer	contraindication	13200003	DOID:750
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Hyperphosphatemia	contraindication	20165001	DOID:0050459
Gastroenteritis	contraindication	25374005	DOID:2326
Hypervitaminosis D	contraindication	27712000	DOID:9971
Sarcoidosis	contraindication	31541009	DOID:11335
Hemosiderosis	contraindication	39011001	DOID:12119
Hemolytic anemia	contraindication	61261009	DOID:583
Hypervitaminosis A	contraindication	64559002	DOID:9972
Ulcerative colitis	contraindication	64766004	DOID:8577
Hypercalcemia	contraindication	66931009	DOID:12678
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Diverticular disease	contraindication	397881000
Hemochromatosis	contraindication	399187006	DOID:2352
Repeated Blood Transfusions	contraindication
Malabsorption States	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.62	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
11-cis retinol dehydrogenase	Enzyme	Q92781	RDH1_HUMAN				WOMBAT-PK
Retinol dehydrogenase 12	Enzyme	Q96NR8	RDH12_HUMAN				WOMBAT-PK
Retinol dehydrogenase 13	Enzyme	Q8NBN7	RDH13_HUMAN				WOMBAT-PK
Retinol-binding protein 3	Surface antigen	P10745	RET3_HUMAN				WOMBAT-PK
Retinol-binding protein 5	Cytosolic other	P82980	RET5_HUMAN				WOMBAT-PK
Retinoid-binding protein 7	Cytosolic other	Q96R05	RET7_HUMAN				WOMBAT-PK
Retinol-binding protein 4	Secreted	P02753	RET4_HUMAN		Kd	6.74	CHEMBL
Retinol-binding protein 2	Cytosolic other	P50120	RET2_HUMAN				WOMBAT-PK
Retinal dehydrogenase 2	Enzyme	O94788	AL1A2_HUMAN				WOMBAT-PK
Retinal dehydrogenase 1	Enzyme	P00352	AL1A1_HUMAN				WOMBAT-PK
Retinaldehyde-binding protein 1	Transporter	P12271	RLBP1_HUMAN				WOMBAT-PK
Retinol-binding protein 1	Cytosolic other	P09455	RET1_HUMAN				WOMBAT-PK
Amyloid beta A4 protein	Unclassified	P05067	A4_HUMAN		IC50	6.75	CHEMBL
Nuclear receptor subfamily 2 group C member 2	Nuclear other	P49116	NR2C2_HUMAN	AGONIST	EC50	4.71	IUPHAR
Alpha-synuclein	Transporter	P37840	SYUA_HUMAN		IC50	6.72	CHEMBL
Beta-lactoglobulin	Unclassified		LACB_BOVIN		Kd	7.44	CHEMBL

External reference:

ID	Source
4021164	VUID
N0000148615	NUI
D06543	KEGG_DRUG
11103-57-4	SECONDARY_CAS_RN
4017648	VANDF
4021164	VANDF
4021715	VANDF
C0042839	UMLSCUI
CHEBI:50211	CHEBI
RTL	PDB_CHEM_ID
CHEMBL986	ChEMBL_ID
CHEMBL1675	ChEMBL_ID
DB00162	DRUGBANK_ID
D014801	MESH_DESCRIPTOR_UI
445354	PUBCHEM_CID
4053	IUPHAR_LIGAND_ID
2243	INN_ID
G2SH0XKK91	UNII
11246	RXNORM
232172	MMSL
5678	MMSL
975	MMSL
d00402	MMSL
001000	NDDF
82156005	SNOMEDCT_US
82622003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
VitafolOne	HUMAN PRESCRIPTION DRUG LABEL	16	0642-0070	CAPSULE, GELATIN COATED	330 ug	ORAL	unapproved drug other	14 sections
Vitafol Caplet	HUMAN PRESCRIPTION DRUG LABEL	12	0642-0072	CAPSULE	6000 [iU]	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol OB Caplet	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0079	TABLET	2700 [iU]	ORAL	Unapproved drug other	14 sections
Vitafol Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0092	CAPSULE, LIQUID FILLED	1100 [iU]	ORAL	UNAPPROVED DRUG OTHER	13 sections
Strovite Forte Caplet	HUMAN PRESCRIPTION DRUG LABEL	19	0642-0204	TABLET, COATED	4000 [iU]	ORAL	UNAPPROVED DRUG OTHER	15 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	900 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
Reaphirm Plant Source DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0642-3010	CAPSULE, GELATIN COATED	1100 [iU]	ORAL	unapproved drug other	7 sections
O-Cal Prenatal Vitamin	HUMAN PRESCRIPTION DRUG LABEL	16	0813-0202	TABLET	2500 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Budpak Vitamin A and D	HUMAN OTC DRUG LABEL	2	27293-036	CREAM	181.80 [iU]	TOPICAL	OTC monograph not final	11 sections
Multivitamin with fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	50090-0356	TABLET, CHEWABLE	2500 [iU]	ORAL	UNAPPROVED DRUG OTHER	8 sections
Multivitamin with fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	50090-0435	TABLET, CHEWABLE	2500 [iU]	ORAL	UNAPPROVED DRUG OTHER	8 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	12	50090-4475	TABLET, CHEWABLE	750 ug	ORAL	unapproved drug other	10 sections
Multi Vitamin and Mineralvitamin	HUMAN OTC DRUG LABEL	11	51220-2001	TABLET, CHEWABLE	3.50 mg	ORAL	unapproved drug other	8 sections
Vitamin A and D	HUMAN OTC DRUG LABEL	2	52000-026	CREAM	181.80 [iU]	TOPICAL	OTC monograph not final	11 sections
Kimchi Vitaminchewable multivitamin	HUMAN OTC DRUG LABEL	11	52102-1001	TABLET, CHEWABLE	0.68 mg	ORAL	unapproved drug other	2 sections
Multi-Vitamin Fluoride Drops	HUMAN PRESCRIPTION DRUG LABEL	10	52959-593	SOLUTION	1500 [iU]	ORAL	Unapproved drug other	11 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-163	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-163	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-164	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-164	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-165	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	11	58657-165	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
M-Natal Plus	HUMAN PRESCRIPTION DRUG LABEL	14	58657-170	TABLET	4000 [iU]	ORAL	unapproved drug other	7 sections
M-Natal Plus	HUMAN PRESCRIPTION DRUG LABEL	14	58657-170	TABLET	4000 [iU]	ORAL	unapproved drug other	7 sections
Tri-Vite Drops with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	4	58657-323	SOLUTION	1500 [iU]	ORAL	unapproved drug other	9 sections
Tri-Vite Drops with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	4	58657-323	SOLUTION	1500 [iU]	ORAL	unapproved drug other	9 sections
Tri-Vite Drops with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	4	58657-324	SOLUTION	1500 [iU]	ORAL	unapproved drug other	9 sections
Tri-Vite Drops with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	4	58657-324	SOLUTION	1500 [iU]	ORAL	unapproved drug other	9 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	12	59088-107	TABLET, CHEWABLE	2500 [iU]	ORAL	unapproved drug other	10 sections
Multivitamin with Fluoride	HUMAN PRESCRIPTION DRUG LABEL	12	59088-107	TABLET, CHEWABLE	750 ug	ORAL	unapproved drug other	10 sections