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benzethonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 3018 | 121-54-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK | 47 | |||
| kinase-selectivity-class | AXL,BRAF,GRK2,PDK4 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D08AJ08 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds |
| ATC | D08AJ58 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds |
| ATC | R02AA09 | RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000891 | Anti-Infective Agents, Local |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35718 | antifungal agent |
| CHEBI has role | CHEBI:48218 | antiseptic drug |
| CHEBI has role | CHEBI:48219 | disinfectant |
Related Drugs by ATC class:
D08AJ Quaternary ammonium compounds 9 drugs
R02AA Antiseptics 15 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Skin irritation | indication | 367466007 | |
| Itching of skin | indication | 418363000 | |
| Minor Skin Wound Pain | indication | ||
| Prevent Minor Bacterial Skin Infection | indication | ||
| Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
| Shock | contraindication | 27942005 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Bleeding hemorrhoids | contraindication | 51551000 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Disorder of mucous membrane | contraindication | 95351003 | |
| Open wound | contraindication | 125643001 | |
| Seizure disorder | contraindication | 128613002 | |
| Heart block | contraindication | 233916004 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Denuded skin | contraindication | 418242004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | GPCR | Ki | 5.93 | DRUG MATRIX | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | Ki | 7.05 | DRUG MATRIX | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 5.89 | DRUG MATRIX | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Ki | 6.05 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 7.43 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.27 | DRUG MATRIX | |||||
| Alpha-2B adrenergic receptor | GPCR | Ki | 6.53 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.00 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.69 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.09 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.44 | DRUG MATRIX | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.02 | DRUG MATRIX | |||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 6.55 | DRUG MATRIX | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 5.97 | DRUG MATRIX | |||||
| Acetylcholinesterase | Enzyme | IC50 | 5.65 | DRUG MATRIX | |||||
| Tyrosine-protein kinase Fyn | Kinase | IC50 | 6.12 | DRUG MATRIX | |||||
| Receptor tyrosine-protein kinase erbB-2 | Kinase | IC50 | 5.68 | DRUG MATRIX | |||||
| Substance-K receptor | GPCR | Ki | 6.19 | DRUG MATRIX | |||||
| KiSS-1 receptor | GPCR | Ki | 5.44 | CHEMBL | |||||
| Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 7.16 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| N0000005872 | NUI |
| D01140 | KEGG_DRUG |
| 10172-60-8 | SECONDARY_CAS_RN |
| 4018649 | VANDF |
| C0005041 | UMLSCUI |
| CHEBI:94725 | CHEBI |
| CHEMBL1182210 | ChEMBL_ID |
| CHEMBL221753 | ChEMBL_ID |
| D001558 | MESH_DESCRIPTOR_UI |
| DB11125 | DRUGBANK_ID |
| 2335 | PUBCHEM_CID |
| 1VU15B70BP | UNII |
| 1390 | RXNORM |
| 11805 | MMSL |
| NOCODE | MMSL |
| 003142 | NDDF |
| 126147005 | SNOMEDCT_US |
| 34929006 | SNOMEDCT_US |
| 373482005 | SNOMEDCT_US |
| 1170 | INN_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Benzethonium chloride and Dyclonine hydrochloride | HUMAN OTC DRUG LABEL | 2 | 0363-0210 | LIQUID | 0.06 mg | TOPICAL | OTC Monograph Drug | 15 sections |
| Benzethonium chloride and Dyclonine hydrochloride | HUMAN OTC DRUG LABEL | 2 | 0363-0210 | LIQUID | 0.06 mg | TOPICAL | OTC Monograph Drug | 15 sections |
| Walgreens Antiseptic Wound Wash | HUMAN OTC DRUG LABEL | 1 | 0363-1507 | SOLUTION | 1.30 mg | TOPICAL | OTC Monograph Drug | 14 sections |
| Walgreens Advanced Wound Hydrogel | HUMAN OTC DRUG LABEL | 2 | 0363-9655 | GEL | 1.20 mg | TOPICAL | OTC Monograph Drug | 13 sections |
| North First Aid Antiseptic | HUMAN OTC DRUG LABEL | 2 | 0498-0015 | SPRAY | 0.20 g | TOPICAL | OTC monograph not final | 11 sections |
| Simply SalineWound Care | HUMAN OTC DRUG LABEL | 1 | 10237-700 | SPRAY | 1 mg | TOPICAL | OTC Monograph Drug | 11 sections |
| TriDerma Pressure Sore Relief | HUMAN OTC DRUG LABEL | 1 | 10738-031 | LIQUID | 0.00 g | TOPICAL | OTC Monograph Drug | 8 sections |
| TriDerma Clean Soothe Bottom Wash | HUMAN OTC DRUG LABEL | 1 | 10738-096 | LIQUID | 0.00 g | TOPICAL | OTC Monograph Drug | 10 sections |
| Bedside-Care | HUMAN OTC DRUG LABEL | 1 | 11701-020 | SHAMPOO | 1 mL | TOPICAL | OTC monograph not final | 10 sections |
| Bedside-Care Foam(Alcohol Free) | HUMAN OTC DRUG LABEL | 1 | 11701-052 | SHAMPOO | 100 mg | TOPICAL | OTC MONOGRAPH DRUG | 10 sections |
| Bedside-Care | HUMAN OTC DRUG LABEL | 1 | 11701-053 | SHAMPOO | 100 mg | TOPICAL | OTC MONOGRAPH DRUG | 10 sections |
| Bedside-Care Perineal Wash | HUMAN OTC DRUG LABEL | 1 | 11701-059 | LIQUID | 1 mL | TOPICAL | OTC monograph not final | 10 sections |
| Benzethonium chloride Plus Dyclonine hydrochloride | HUMAN OTC DRUG LABEL | 2 | 11822-0128 | LIQUID | 0.20 mg | TOPICAL | OTC Monograph Drug | 15 sections |
| 3 in 1 First Aid Wound Care | HUMAN OTC DRUG LABEL | 1 | 11822-5074 | SOLUTION | 1.30 mg | TOPICAL | OTC Monograph Drug | 14 sections |
| Mada MedicalFoam Sanitizer | HUMAN OTC DRUG LABEL | 1 | 11928-682 | LIQUID | 0.20 mL | TOPICAL | OTC monograph not final | 8 sections |
| Veti-Foam | HUMAN OTC DRUG LABEL | 1 | 13985-529 | LIQUID | 2 g | TOPICAL | OTC MONOGRAPH NOT FINAL | 14 sections |
| New Skin Bandage | HUMAN OTC DRUG LABEL | 1 | 16864-440 | LIQUID | 1.80 mg | TOPICAL | OTC Monograph Drug | 15 sections |
| New Skin Bandage | HUMAN OTC DRUG LABEL | 1 | 16864-450 | SPRAY | 60 mg | TOPICAL | OTC Monograph Drug | 15 sections |
| Dermoplast KidsFirst Aid | HUMAN OTC DRUG LABEL | 2 | 16864-660 | SPRAY | 2 mg | TOPICAL | OTC Monograph Drug | 15 sections |
| Dermoplast First Aid | HUMAN OTC DRUG LABEL | 2 | 16864-670 | SPRAY | 2 mg | TOPICAL | OTC Monograph Drug | 15 sections |
| Wet Wipes | HUMAN OTC DRUG LABEL | 1 | 20276-432 | SWAB | 0.30 mL | TOPICAL | OTC monograph not final | 11 sections |
| Wet Wipes | HUMAN OTC DRUG LABEL | 1 | 20276-433 | SWAB | 0.30 mL | TOPICAL | OTC monograph not final | 11 sections |
| Saline Wound WashSignature Care | HUMAN OTC DRUG LABEL | 1 | 21130-762 | LIQUID | 0.10 g | TOPICAL | OTC monograph not final | 7 sections |
| TerrasilMed Wound Cleanser | HUMAN OTC DRUG LABEL | 2 | 24909-028 | OINTMENT | 0.20 g | TOPICAL | OTC Monograph Drug | 7 sections |
| TERRASIL WOUND CARE | HUMAN OTC DRUG LABEL | 2 | 24909-115 | OINTMENT | 0.50 g | TOPICAL | OTC monograph not final | 7 sections |
| Terrasil Wound CareMAX | HUMAN OTC DRUG LABEL | 2 | 24909-116 | OINTMENT | 0.20 g | TOPICAL | OTC monograph not final | 8 sections |
| Terrasil Wound Care | HUMAN OTC DRUG LABEL | 2 | 24909-117 | OINTMENT | 0.10 g | TOPICAL | OTC monograph not final | 8 sections |
| Terrasil Skin Repair | HUMAN OTC DRUG LABEL | 2 | 24909-131 | OINTMENT | 0.10 g | TOPICAL | OTC monograph not final | 11 sections |
| Terrasil Skin RepairMAX | HUMAN OTC DRUG LABEL | 2 | 24909-132 | OINTMENT | 0.20 g | TOPICAL | OTC monograph not final | 11 sections |
| Fastrin Infection Control Skin Repair | HUMAN OTC DRUG LABEL | 1 | 24909-602 | OINTMENT | 0.20 g | TOPICAL | OTC monograph not final | 8 sections |