benzethonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3018	121-54-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzethonium benzethionium chloride benzethonium chloride benzetonium chloride	Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade. Molecular weight: 412.64 Formula: C27H42NO2 CLOGP: 4.29 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 18.46 ALOGS: -7.78 ROTB: 12

Molecule

Description

Molfile Inchi Smiles

Synonyms:

benzethonium
benzethionium chloride
benzethonium chloride
benzetonium chloride

Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. It is an ingredient in medicaments, deodorants, mouthwashes, etc., and is used to disinfect apparatus, etc., in the food processing and pharmaceutical industries, in surgery, and also as a preservative. The compound is toxic orally as a result of neuromuscular blockade.

Molecular weight: 412.64
Formula: C27H42NO2
CLOGP: 4.29
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 18.46
ALOGS: -7.78
ROTB: 12

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	5734.29	23.32	1985	14917	129904	50458318
Toxicity to various agents	3460.07	23.32	1579	15323	210920	50377302
Drug abuse	1620.48	23.32	643	16259	59203	50529019
Intentional overdose	1151.12	23.32	511	16391	61993	50526229
Cardio-respiratory arrest	1137.01	23.32	485	16417	53407	50534815
Overdose	829.14	23.32	476	16426	99251	50488971
Suicide attempt	672.49	23.32	333	16569	51399	50536823
Alcohol interaction	475.27	23.32	116	16786	2028	50586194
Suspected suicide	416.58	23.32	127	16775	5230	50582992
Respiratory arrest	322.04	23.32	170	16732	29839	50558383
Intentional product misuse	321.60	23.32	198	16704	46536	50541686
Cardiac arrest	288.25	23.32	232	16670	83419	50504803
Alcohol poisoning	259.00	23.32	69	16833	1731	50586491
Death	231.14	23.32	399	16503	324980	50263242
Alcohol use	219.83	23.32	62	16840	1933	50586289
Coma	206.97	23.32	163	16739	56716	50531506
Alcohol abuse	182.22	23.32	53	16849	1848	50586374
Somnolence	176.35	23.32	237	16665	154748	50433474
Drug ineffective	170.47	23.32	34	16868	819299	49768923
Exposure to toxic agent	140.60	23.32	51	16851	3607	50584615
Pain	110.14	23.32	29	16873	578874	50009348
Poisoning deliberate	105.65	23.32	52	16850	7860	50580362
Loss of consciousness	101.25	23.32	148	16754	104205	50484017
Diarrhoea	96.85	23.32	38	16864	588438	49999784
Mydriasis	93.91	23.32	53	16849	10574	50577648
Agitation	92.19	23.32	101	16801	53283	50534939
Fatigue	90.94	23.32	63	16839	707538	49880684
Arthralgia	89.20	23.32	19	16883	438683	50149539
Blood alcohol increased	86.61	23.32	23	16879	569	50587653
Poisoning	83.67	23.32	52	16850	12377	50575845
Alcoholism	83.06	23.32	28	16874	1592	50586630
Postmortem blood drug level abnormal	82.52	23.32	20	16882	338	50587884
Intentional self-injury	77.07	23.32	63	16839	23049	50565173
Substance abuse	76.42	23.32	34	16868	4090	50584132
Rash	72.27	23.32	28	16874	437443	50150779
Joint swelling	69.19	23.32	3	16899	245283	50342939
Seizure	67.32	23.32	132	16770	117742	50470480
Myocarditis	63.18	23.32	37	16865	7910	50580312
Condition aggravated	62.09	23.32	12	16890	297046	50291176
Drug dependence	62.00	23.32	52	16850	19707	50568515
Abdominal discomfort	61.68	23.32	4	16898	231637	50356585
Aggression	61.01	23.32	53	16849	21063	50567159
Drug use disorder	59.09	23.32	26	16876	3046	50585176
Alopecia	57.80	23.32	7	16895	245040	50343182
Suicidal ideation	57.23	23.32	81	16821	55304	50532918
Drug interaction	57.06	23.32	171	16731	199450	50388772
Drug withdrawal syndrome	56.94	23.32	55	16847	25026	50563196
Victim of sexual abuse	56.52	23.32	16	16886	505	50587717
Dyspnoea	56.48	23.32	60	16842	547548	50040674
Metabolic acidosis	56.09	23.32	67	16835	38758	50549464
Depressed level of consciousness	53.71	23.32	76	16826	51877	50536345
Liver injury	53.70	23.32	53	16849	24753	50563469
Pyrexia	51.15	23.32	32	16870	380171	50208051
Pneumonia	50.70	23.32	32	16870	378369	50209853
Swelling	49.22	23.32	5	16897	200867	50387355
Pruritus	48.69	23.32	17	16885	283551	50304671
Off label use	47.74	23.32	53	16849	474373	50113849
Drug intolerance	47.60	23.32	8	16894	219096	50369126
Asthenia	45.51	23.32	25	16877	319017	50269205
Anaemia	45.33	23.32	14	16888	252442	50335780
Drug hypersensitivity	44.92	23.32	14	16888	250996	50337226
Rheumatoid arthritis	44.88	23.32	7	16895	202543	50385679
Pain in extremity	44.10	23.32	18	16884	272847	50315375
Tachycardia	43.35	23.32	100	16802	99663	50488559
Somnambulism	41.99	23.32	24	16878	4900	50583322
Electrocardiogram QT prolonged	41.01	23.32	67	16835	51819	50536403
Chemical submission	40.67	23.32	10	16892	180	50588042
Sopor	40.32	23.32	41	16861	19838	50568384
Electrocardiogram QRS complex prolonged	40.17	23.32	24	16878	5320	50582902
Sinusitis	39.88	23.32	5	16897	170553	50417669
Asphyxia	39.83	23.32	24	16878	5403	50582819
Headache	38.60	23.32	69	16833	506466	50081756
Nasopharyngitis	37.81	23.32	9	16893	192918	50395304
Peripheral swelling	37.72	23.32	11	16891	205925	50382297
Product dose omission issue	37.18	23.32	8	16894	183830	50404392
Weight increased	36.58	23.32	11	16891	201880	50386342
Neutropenia	35.43	23.32	4	16898	147961	50440261
Protein C increased	34.48	23.32	8	16894	111	50588111
Urinary tract infection	34.24	23.32	16	16886	224004	50364218
Homicide	34.01	23.32	10	16892	362	50587860
Amnesia	33.97	23.32	55	16847	42205	50546017
Ventricular tachycardia	32.76	23.32	33	16869	15788	50572434
Treatment failure	32.26	23.32	4	16898	137633	50450589
Constipation	32.08	23.32	11	16891	185697	50402525
Broncholithiasis	32.03	23.32	8	16894	154	50588068
Lichen nitidus	32.01	23.32	7	16895	73	50588149
Cough	31.45	23.32	21	16881	241243	50346979
Accidental death	31.10	23.32	14	16888	1730	50586492
Nausea	30.47	23.32	127	16775	705271	49882951
Back pain	30.26	23.32	18	16884	220012	50368210
Substance dependence	30.20	23.32	8	16894	196	50588026
Abnormal behaviour	30.16	23.32	35	16867	19623	50568599
Induced abortion failed	29.07	23.32	8	16894	227	50587995
Lymph node calcification	28.97	23.32	8	16894	230	50587992
Shock	28.77	23.32	35	16867	20615	50567607
Hypotension	28.30	23.32	154	16748	235315	50352907
Sexual abuse	27.77	23.32	7	16895	140	50588082
Road traffic accident	27.21	23.32	37	16865	24315	50563907
Musculoskeletal stiffness	27.21	23.32	5	16897	128476	50459746
Congenital umbilical hernia	26.81	23.32	8	16894	305	50587917
Disinhibition	26.37	23.32	10	16892	800	50587422
Sinus tachycardia	26.25	23.32	34	16868	21320	50566902
Aspiration	26.24	23.32	23	16879	9241	50578981
Areflexia	24.92	23.32	14	16888	2766	50585456
Euphoric mood	24.87	23.32	16	16886	4039	50584183
Respiratory depression	24.77	23.32	25	16877	11985	50576237
Electrocardiogram ST segment elevation	24.56	23.32	15	16887	3458	50584764
Postmortem blood drug level	24.35	23.32	6	16896	109	50588113
Injection site pain	24.21	23.32	4	16898	111020	50477202
Blood ethanol increased	24.14	23.32	6	16896	113	50588109
Alcoholic	24.05	23.32	5	16897	40	50588182
Stomatitis	23.61	23.32	3	16899	101341	50486881
Malaise	23.49	23.32	48	16854	335484	50252738

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	4132.32	22.62	1664	18672	78219	29475972
Completed suicide	3668.34	22.62	1584	18752	88662	29465529
Toxicity to various agents	3235.47	22.62	1786	18550	171875	29382316
Intentional overdose	796.10	22.62	429	19907	38099	29516092
Cardio-respiratory arrest	785.17	22.62	467	19869	50134	29504057
Overdose	591.99	22.62	467	19869	79352	29474839
Alcohol abuse	533.34	22.62	173	20163	4160	29550031
Alcohol interaction	502.24	22.62	148	20188	2555	29551636
Suicide attempt	479.74	22.62	296	20040	33814	29520377
Intentional product misuse	475.37	22.62	296	20040	34365	29519826
Suspected suicide	369.91	22.62	129	20207	3891	29550300
Substance abuse	281.16	22.62	122	20214	6665	29547526
Alcohol poisoning	276.02	22.62	97	20239	2992	29551199
Drug dependence	269.32	22.62	172	20164	20809	29533382
Aggression	186.65	22.62	171	20165	35370	29518821
Respiratory arrest	186.08	22.62	149	20187	25684	29528507
Coma	175.18	22.62	173	20163	39277	29514914
Alcohol use	172.48	22.62	69	20267	3063	29551128
Respiratory depression	154.22	22.62	103	20233	13420	29540771
Exposure to toxic agent	135.82	22.62	55	20281	2520	29551671
Poisoning deliberate	129.72	22.62	68	20268	5663	29548528
Asphyxia	128.73	22.62	66	20270	5249	29548942
Intentional product use issue	124.94	22.62	150	20186	42348	29511843
Diarrhoea	116.44	22.62	42	20294	332656	29221535
Incorrect route of product administration	110.63	22.62	77	20259	10724	29543467
Blood alcohol increased	105.66	22.62	33	20303	697	29553494
Cardiac arrest	105.23	22.62	201	20135	85390	29468801
Pneumonia	102.89	22.62	46	20290	320126	29234065
Drug ineffective	95.40	22.62	67	20269	363103	29191088
Poisoning	92.54	22.62	67	20269	9926	29544265
Pyrexia	86.73	22.62	45	20291	287577	29266614
Fatigue	85.07	22.62	57	20279	316764	29237427
Anaemia	83.85	22.62	18	20318	200933	29353258
Drug withdrawal syndrome	83.72	22.62	81	20255	17903	29536288
Suicidal ideation	79.07	22.62	108	20228	34608	29519583
Rash	75.22	22.62	19	20317	189800	29364391
Neutropenia	74.27	22.62	4	20332	131707	29422484
Intentional self-injury	69.34	22.62	62	20274	12399	29541792
Alcohol withdrawal syndrome	67.87	22.62	28	20308	1345	29552846
Drug interaction	61.96	22.62	284	20052	197101	29357090
Death	57.80	22.62	417	19919	341667	29212524
Dyspnoea	57.53	22.62	85	20251	326647	29227544
Off label use	54.17	22.62	77	20259	300723	29253468
Drug use disorder	53.90	22.62	32	20304	3390	29550801
Miosis	52.98	22.62	44	20292	7965	29546226
Medication error	52.89	22.62	69	20267	21142	29533049
Agitation	52.81	22.62	112	20224	51192	29502999
Road traffic accident	52.49	22.62	59	20277	15502	29538689
Drug screen positive	50.80	22.62	32	20304	3769	29550422
Sopor	50.41	22.62	49	20287	10885	29543306
Accidental death	50.41	22.62	26	20310	2092	29552099
Alcoholism	50.23	22.62	28	20308	2633	29551558
Sepsis	49.75	22.62	18	20318	142664	29411527
Alcohol intolerance	49.49	22.62	16	20320	379	29553812
Arthralgia	48.02	22.62	18	20318	139599	29414592
Pain	47.02	22.62	30	20306	171402	29382789
Asthenia	46.21	22.62	48	20288	215202	29338989
Constipation	45.99	22.62	11	20325	114149	29440042
Mydriasis	45.69	22.62	36	20300	6049	29548142
Depressed level of consciousness	45.60	22.62	87	20249	36855	29517336
Hepatic fibrosis	45.02	22.62	28	20308	3224	29550967
Ex-drug abuser	44.87	22.62	12	20324	142	29554049
Disease progression	44.60	22.62	3	20333	81913	29472278
Haemoglobin decreased	44.54	22.62	10	20326	108365	29445826
Platelet count decreased	44.36	22.62	9	20327	104663	29449528
Amnesia	43.52	22.62	65	20271	22578	29531613
White blood cell count decreased	42.74	22.62	4	20332	83358	29470833
Fractional exhaled nitric oxide increased	42.15	22.62	14	20322	362	29553829
Pain in extremity	41.90	22.62	12	20324	110421	29443770
Infection	41.23	22.62	3	20333	76748	29477443
Nausea	40.27	22.62	87	20249	289168	29265023
Pancytopenia	40.07	22.62	5	20331	83163	29471028
General physical health deterioration	39.34	22.62	11	20325	102846	29451345
Decreased appetite	39.07	22.62	26	20310	145316	29408875
Somnolence	38.63	22.62	147	20189	93808	29460383
Product dose omission issue	37.44	22.62	10	20326	96373	29457818
Impaired driving ability	37.24	22.62	22	20314	2309	29551882
Back pain	37.20	22.62	12	20324	102272	29451919
Malignant neoplasm progression	36.68	22.62	4	20332	73855	29480336
Tachycardia	36.36	22.62	121	20215	72289	29481902
Drug abuser	36.20	22.62	26	20310	3801	29550390
Withdrawal syndrome	35.91	22.62	41	20295	10951	29543240
Metabolic acidosis	35.08	22.62	79	20257	37583	29516608
Pulmonary oedema	33.69	22.62	84	20252	42651	29511540
Cardiac failure congestive	33.68	22.62	6	20330	76575	29477616
Cough	33.61	22.62	23	20313	126704	29427487
Dysarthria	33.56	22.62	69	20267	30842	29523349
Loss of consciousness	33.05	22.62	119	20217	73937	29480254
Homicide	33.00	22.62	15	20321	913	29553278
Thrombocytopenia	32.51	22.62	27	20309	134796	29419395
Neuropathy peripheral	32.49	22.62	5	20331	71022	29483169
Foetal alcohol syndrome	31.63	22.62	9	20327	136	29554055
Oedema peripheral	29.93	22.62	17	20319	103540	29450651
Weight decreased	29.77	22.62	36	20300	150869	29403322
Urinary tract infection	29.07	22.62	7	20329	72347	29481844
Peripheral swelling	28.01	22.62	5	20331	63734	29490457
Myocardial fibrosis	28.01	22.62	14	20322	1054	29553137
Cerebrovascular accident	28.00	22.62	9	20327	76902	29477289
Physical assault	27.81	22.62	14	20322	1070	29553121
Brain oedema	27.77	22.62	38	20298	12182	29542009
Dehydration	27.63	22.62	23	20313	114725	29439466
Cardiac failure	27.61	22.62	10	20326	79277	29474914
Pruritus	27.43	22.62	24	20312	116825	29437366
Opiates positive	27.01	22.62	11	20325	511	29553680
Abdominal pain	27.00	22.62	32	20304	135325	29418866
Myocardial infarction	26.69	22.62	22	20314	110274	29443917
Deep vein thrombosis	26.34	22.62	4	20332	57395	29496796
Choroiditis	26.05	22.62	13	20323	975	29553216
Sensorimotor disorder	26.00	22.62	10	20326	399	29553792
Septic shock	25.23	22.62	6	20330	62554	29491637
Pleural effusion	25.15	22.62	9	20327	71899	29482292
Gun shot wound	24.90	22.62	13	20323	1072	29553119
Blood creatinine increased	24.54	22.62	14	20322	85088	29469103
Dextrocardia	24.11	22.62	7	20329	114	29554077
Unresponsive to stimuli	23.72	22.62	53	20283	25073	29529118
Shock	23.49	22.62	48	20288	21356	29532835
Rhabdomyolysis	23.22	22.62	93	20243	60715	29493476
Muscular weakness	23.05	22.62	7	20329	62045	29492146
Plantar fasciitis	22.88	22.62	13	20323	1268	29552923

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	8839.30	21.76	3525	29515	220889	64244803
Toxicity to various agents	6445.29	21.76	3273	29767	360240	64105452
Drug abuse	5600.30	21.76	2202	30838	130172	64335520
Cardio-respiratory arrest	1884.61	21.76	944	32096	97449	64368243
Intentional overdose	1546.87	21.76	803	32237	89141	64376551
Overdose	1149.18	21.76	815	32225	158751	64306941
Alcohol interaction	809.12	21.76	224	32816	4177	64461515
Intentional product misuse	756.46	21.76	467	32573	71828	64393864
Suicide attempt	715.85	21.76	448	32592	70559	64395133
Suspected suicide	711.27	21.76	237	32803	8417	64457275
Alcohol abuse	538.55	21.76	167	32873	4685	64461007
Respiratory arrest	480.71	21.76	313	32727	52672	64413020
Alcohol poisoning	436.90	21.76	138	32902	4117	64461575
Cardiac arrest	356.14	21.76	416	32624	153648	64312044
Death	335.59	21.76	752	32288	481953	63983739
Coma	335.04	21.76	310	32730	87305	64378387
Alcohol use	326.83	21.76	113	32927	4489	64461203
Substance abuse	301.64	21.76	129	32911	9163	64456529
Drug dependence	300.01	21.76	196	32844	33116	64432576
Exposure to toxic agent	266.33	21.76	105	32935	6054	64459638
Drug ineffective	221.09	21.76	78	32962	840169	63625523
Poisoning deliberate	218.54	21.76	116	32924	13342	64452350
Diarrhoea	197.08	21.76	63	32977	722641	63743051
Aggression	193.05	21.76	172	32868	46060	64419632
Blood alcohol increased	166.92	21.76	49	32991	1133	64464559
Fatigue	161.50	21.76	92	32948	748638	63717054
Pain	158.44	21.76	44	32996	553467	63912225
Poisoning	150.30	21.76	109	32931	21770	64443922
Arthralgia	138.53	21.76	29	33011	442231	64023461
Respiratory depression	132.65	21.76	104	32936	23339	64442353
Asphyxia	131.87	21.76	74	32966	9492	64456200
Incorrect route of product administration	131.06	21.76	103	32937	23195	64442497
Somnolence	129.32	21.76	307	32733	203338	64262354
Pneumonia	128.96	21.76	63	32977	559513	63906179
Pyrexia	125.57	21.76	65	32975	558579	63907113
Intentional product use issue	124.10	21.76	195	32845	95169	64370523
Off label use	123.58	21.76	87	32953	632719	63832973
Dyspnoea	120.32	21.76	115	32925	718559	63747133
Agitation	119.59	21.76	184	32856	88183	64377509
Rash	119.44	21.76	43	32997	458506	64007186
Intentional self-injury	115.18	21.76	105	32935	28939	64436753
Anaemia	110.28	21.76	29	33011	378651	64087041
Mydriasis	106.79	21.76	77	32963	15235	64450457
Drug use disorder	100.58	21.76	53	32987	6001	64459691
Nausea	100.54	21.76	155	32885	785645	63680047
Joint swelling	93.23	21.76	4	33036	215378	64250314
Neutropenia	93.10	21.76	8	33032	239616	64226076
Metabolic acidosis	88.02	21.76	142	32898	70816	64394876
Postmortem blood drug level abnormal	87.77	21.76	26	33014	621	64465071
Loss of consciousness	86.97	21.76	217	32823	148148	64317544
Depressed level of consciousness	85.14	21.76	151	32889	81285	64384407
Pain in extremity	84.86	21.76	25	33015	303060	64162632
Alcoholism	83.82	21.76	39	33001	3378	64462314
Drug interaction	83.73	21.76	387	32653	361696	64103996
Accidental death	80.61	21.76	39	33001	3686	64462006
Suicidal ideation	79.59	21.76	131	32909	66411	64399281
Febrile neutropenia	79.54	21.76	4	33036	187653	64278039
Cough	77.45	21.76	29	33011	302119	64163573
Asthenia	76.83	21.76	64	32976	427980	64037712
Urinary tract infection	72.78	21.76	15	33025	231581	64234111
Condition aggravated	71.48	21.76	52	32988	372374	64093318
Miosis	71.06	21.76	57	32983	13209	64452483
Pruritus	70.56	21.76	36	33004	312364	64153328
Constipation	69.74	21.76	16	33024	229321	64236371
Drug intolerance	68.51	21.76	8	33032	187984	64277708
Alcohol withdrawal syndrome	68.46	21.76	28	33012	1775	64463917
Headache	67.96	21.76	104	32936	529363	63936329
Back pain	65.81	21.76	23	33017	250148	64215544
Nasopharyngitis	65.23	21.76	11	33029	196062	64269630
Drug withdrawal syndrome	64.70	21.76	80	32960	31211	64434481
Alopecia	63.07	21.76	6	33034	165684	64300008
Peripheral swelling	62.78	21.76	15	33025	209138	64256554
Pulmonary oedema	62.67	21.76	130	32910	78544	64387148
Rheumatoid arthritis	62.41	21.76	6	33034	164288	64301404
Sopor	61.60	21.76	76	32964	29585	64436107
Abdominal discomfort	61.16	21.76	10	33030	182312	64283380
Sepsis	60.89	21.76	21	33019	230320	64235372
Tachycardia	60.28	21.76	191	32849	149388	64316304
Drug hypersensitivity	58.98	21.76	24	33016	237791	64227901
Weight increased	57.17	21.76	19	33021	213329	64252363
Haemoglobin decreased	54.72	21.76	16	33024	195047	64270645
Homicide	54.63	21.76	21	33019	1130	64464562
Product dose omission issue	54.58	21.76	16	33024	194731	64270961
White blood cell count decreased	54.43	21.76	8	33032	157829	64307863
Decreased appetite	54.29	21.76	39	33001	281250	64184442
Disease progression	54.27	21.76	5	33035	141675	64324017
Drug abuser	54.27	21.76	35	33005	5773	64459919
Sinusitis	53.69	21.76	6	33034	145922	64319770
General physical health deterioration	53.40	21.76	19	33021	204406	64261286
Drug screen positive	52.24	21.76	34	33006	5695	64459997
Swelling	51.10	21.76	10	33030	160208	64305484
Weight decreased	50.86	21.76	43	32997	285696	64179996
Shock	50.81	21.76	79	32961	38161	64427531
Malaise	50.62	21.76	78	32962	396169	64069523
Pancytopenia	50.03	21.76	7	33033	143302	64322390
Infection	48.60	21.76	17	33023	184863	64280829
Opiates positive	48.47	21.76	18	33022	880	64464812
Electrocardiogram QRS complex prolonged	47.99	21.76	39	33001	9205	64456487
Treatment failure	47.91	21.76	3	33037	116813	64348879
Medication error	47.57	21.76	89	32951	49877	64415815
Road traffic accident	45.80	21.76	67	32973	30678	64435014
Hypersensitivity	43.78	21.76	23	33017	196429	64269263
Platelet count decreased	43.09	21.76	16	33024	167695	64297997
Blood ethanol increased	42.27	21.76	15	33025	643	64465049
Cardiac failure congestive	41.95	21.76	8	33032	130572	64335120
Thrombocytopenia	41.91	21.76	32	33008	223769	64241923
Urticaria	41.46	21.76	12	33028	147305	64318387
Hepatic fibrosis	41.19	21.76	29	33011	5523	64460169
Dizziness	40.78	21.76	101	32939	430062	64035630
Amnesia	39.89	21.76	81	32959	48188	64417504
Stomatitis	39.09	21.76	5	33035	109600	64356092
Rhabdomyolysis	38.65	21.76	119	32921	91607	64374085
Malignant neoplasm progression	38.27	21.76	6	33034	112865	64352827
Product administration error	37.97	21.76	58	32982	27585	64438107
Injection site pain	37.59	21.76	6	33034	111402	64354290
Abdominal pain	37.51	21.76	64	32976	312311	64153381
Cerebrovascular accident	37.29	21.76	12	33028	137571	64328121
Liver injury	37.22	21.76	60	32980	29872	64435820
Septic shock	37.15	21.76	5	33035	105432	64360260
Musculoskeletal stiffness	36.63	21.76	9	33031	123197	64342495
Unresponsive to stimuli	36.35	21.76	80	32960	50313	64415379
Electrocardiogram QT prolonged	35.28	21.76	105	32935	79343	64386349
Abdominal distension	35.17	21.76	4	33036	95990	64369702
Fall	34.89	21.76	104	32936	416722	64048970
Blood ethanol	34.89	21.76	9	33031	126	64465566
Accidental overdose	34.76	21.76	62	32978	33495	64432197
Chemical submission	34.62	21.76	10	33030	218	64465474
Brain oedema	34.18	21.76	49	32991	22026	64443666
Amphetamines positive	34.07	21.76	10	33030	231	64465461
Pulmonary congestion	34.07	21.76	51	32989	23829	64441863
Sinus tachycardia	34.02	21.76	60	32980	32128	64433564
Somnambulism	33.91	21.76	25	33015	5116	64460576
Interstitial lung disease	33.58	21.76	5	33035	97727	64367965
Toxicologic test abnormal	33.24	21.76	15	33025	1210	64464482
Therapeutic product effect decreased	33.19	21.76	9	33031	115342	64350350
Postmortem blood drug level	33.10	21.76	10	33030	256	64465436
Alcohol intolerance	33.08	21.76	11	33029	387	64465305
Victim of sexual abuse	32.83	21.76	11	33029	396	64465296
Deep vein thrombosis	32.63	21.76	7	33033	105175	64360517
Myocardial fibrosis	32.56	21.76	16	33024	1564	64464128
Euphoric mood	32.52	21.76	27	33013	6564	64459128
Abnormal behaviour	32.14	21.76	60	32980	33562	64432130
Withdrawal syndrome	31.86	21.76	49	32991	23443	64442249
Dehydration	31.31	21.76	39	33001	216724	64248968
Substance dependence	30.84	21.76	11	33029	479	64465213
Dysarthria	30.75	21.76	83	32957	59323	64406369
Mobility decreased	30.41	21.76	4	33036	85836	64379856
Oedema peripheral	29.18	21.76	39	33001	210278	64255414
Lichen nitidus	28.77	21.76	7	33033	76	64465616
Pulmonary embolism	28.59	21.76	20	33020	146336	64319356
Respiratory acidosis	28.52	21.76	30	33010	9825	64455867
Restlessness	28.51	21.76	63	32977	39722	64425970
Seizure	28.42	21.76	164	32876	166728	64298964
Acute hepatic failure	28.02	21.76	49	32991	26063	64439629
Influenza	27.63	21.76	10	33030	106521	64359171
Oropharyngeal pain	27.39	21.76	6	33034	88861	64376831
Herpes zoster	27.32	21.76	4	33036	79183	64386509
Impaired driving ability	27.08	21.76	21	33019	4633	64461059
Physical assault	27.01	21.76	14	33026	1532	64464160
Bronchitis	26.89	21.76	11	33029	108732	64356960
Muscular weakness	26.78	21.76	16	33024	127322	64338370
Protein C increased	26.75	21.76	7	33033	104	64465588
Pleural effusion	26.48	21.76	16	33024	126543	64339149
Musculoskeletal pain	26.07	21.76	5	33035	81289	64384403
Substance use disorder	26.01	21.76	9	33031	358	64465334
Chest pain	25.94	21.76	51	32989	235929	64229763
Leukopenia	25.43	21.76	10	33030	101232	64364460
Choroiditis	25.40	21.76	12	33028	1075	64464617
Arthritis	25.15	21.76	6	33034	83808	64381884
Bezoar	24.94	21.76	15	33025	2188	64463504
Broncholithiasis	24.52	21.76	7	33033	146	64465546
Loss of personal independence in daily activities	24.22	21.76	4	33036	72450	64393242
Chills	23.97	21.76	21	33019	137243	64328449
Discomfort	23.86	21.76	6	33034	80872	64384820
Abdominal pain upper	23.73	21.76	33	33007	174997	64290695
Injection site erythema	23.47	21.76	4	33036	70796	64394896
Oedema	23.22	21.76	9	33031	91926	64373766
Induced abortion failed	22.99	21.76	7	33033	184	64465508
Aspiration	22.59	21.76	35	33005	16850	64448842
Sensorimotor disorder	22.44	21.76	10	33030	783	64464909
Hypoaesthesia	22.29	21.76	23	33017	139085	64326607
Cardiac failure	22.23	21.76	21	33019	132352	64333340
Drug level increased	22.11	21.76	52	32988	34144	64431548
Accidental poisoning	22.11	21.76	12	33028	1441	64464251
Blister	22.04	21.76	7	33033	80960	64384732
Exposure via ingestion	21.97	21.76	19	33021	4883	64460809
Erythema	21.82	21.76	39	33001	187031	64278661
Dyspepsia	21.76	21.76	7	33033	80305	64385387

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AJ08	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds
ATC	D08AJ58	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds
ATC	R02AA09	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
CHEBI has role	CHEBI:22587	antiviral agents
CHEBI has role	CHEBI:33282	bactericides
CHEBI has role	CHEBI:35718	antifungal agents
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Skin irritation	indication	367466007
Itching of skin	indication	418363000
Minor Skin Wound Pain	indication
Prevent Minor Bacterial Skin Infection	indication
Bacterial septicemia	contraindication	10001005	DOID:0040085
Shock	contraindication	27942005
Conduction disorder of the heart	contraindication	44808001
Bleeding hemorrhoids	contraindication	51551000
Decreased respiratory function	contraindication	80954004
Disorder of mucous membrane	contraindication	95351003
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Heart block	contraindication	233916004
Disease of liver	contraindication	235856003	DOID:409
Denuded skin	contraindication	418242004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN	Ki	5.93	DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN	Ki	7.05	DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	Ki	5.89	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	Ki	6.05	DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	Ki	7.43	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN	Ki	6.27	DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN	Ki	6.53	DRUG MATRIX
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN	Ki	7.00	DRUG MATRIX
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN	Ki	6.69	DRUG MATRIX
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN	Ki	7.09	DRUG MATRIX
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN	Ki	7.44	DRUG MATRIX
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN	Ki	7.02	DRUG MATRIX
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN	Ki	6.55	DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN	Ki	5.97	DRUG MATRIX
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN	IC50	5.65	DRUG MATRIX
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN	IC50	6.12	DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2	Kinase	P04626	ERBB2_HUMAN	IC50	5.68	DRUG MATRIX
Substance-K receptor	GPCR	P21452	NK2R_HUMAN	Ki	6.19	DRUG MATRIX
KiSS-1 receptor	GPCR	Q969F8	KISSR_HUMAN	Ki	5.44	CHEMBL
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT	Ki	7.16	DRUG MATRIX

External reference:

ID	Source
N0000005872	NUI
D01140	KEGG_DRUG
4018649	VANDF
C0005041	UMLSCUI
CHEBI:94725	CHEBI
CHEMBL1182210	ChEMBL_ID
CHEMBL221753	ChEMBL_ID
D001558	MESH_DESCRIPTOR_UI
DB11125	DRUGBANK_ID
2335	PUBCHEM_CID
1VU15B70BP	UNII
1390	RXNORM
11805	MMSL
NOCODE	MMSL
003142	NDDF
126147005	SNOMEDCT_US
34929006	SNOMEDCT_US
373482005	SNOMEDCT_US
1170	INN_ID
10172-60-8	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Benzethonium chloride and Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0210	LIQUID	0.06 mg	TOPICAL	OTC monograph not final	15 sections
Walgreens Antiseptic Wound Wash	HUMAN OTC DRUG LABEL	1	0363-1507	SOLUTION	1.30 mg	TOPICAL	OTC monograph not final	14 sections
Pyrocaine Burn	HUMAN OTC DRUG LABEL	2	0498-0010	AEROSOL, SPRAY	0.20 g	TOPICAL	OTC monograph not final	11 sections
Pyrocaine Burn	HUMAN OTC DRUG LABEL	2	0498-0011	AEROSOL, SPRAY	0.20 g	TOPICAL	OTC monograph not final	11 sections
North First Aid Antiseptic	HUMAN OTC DRUG LABEL	2	0498-0015	SPRAY	0.20 g	TOPICAL	OTC monograph not final	11 sections
North Burn	HUMAN OTC DRUG LABEL	3	0498-0020	SPRAY	0.20 g	TOPICAL	OTC monograph not final	12 sections
Burn Water Soluble	HUMAN OTC DRUG LABEL	3	0498-0021	SPRAY	0.20 g	TOPICAL	OTC monograph not final	12 sections
North First Aid Antiseptic Water Soluble	HUMAN OTC DRUG LABEL	2	0498-0030	SPRAY	0.20 g	TOPICAL	OTC monograph not final	13 sections
First Aid Antiseptic Water Soluble	HUMAN OTC DRUG LABEL	2	0498-0031	SPRAY	0.20 g	TOPICAL	OTC monograph not final	13 sections
Simply Saline Plus Wound WashAntibacterial First Aid Antiseptic	HUMAN OTC DRUG LABEL	1	10237-694	SPRAY	0.13 mL	TOPICAL	OTC monograph not final	10 sections
Simply SalineWound Care	HUMAN OTC DRUG LABEL	1	10237-700	SPRAY	1 mg	TOPICAL	OTC monograph not final	11 sections
Moisturizing Hand Sanitizer	HUMAN OTC DRUG LABEL	1	11344-478	LOTION	1.98 mg	TOPICAL	OTC monograph not final	10 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11673-629	LIQUID	0.20 mg	TOPICAL	OTC monograph not final	15 sections
Bedside-Care	HUMAN OTC DRUG LABEL	1	11701-020	SHAMPOO	1 mL	TOPICAL	OTC monograph not final	10 sections
Bedside-Care Foam (Alcohol Free)	HUMAN OTC DRUG LABEL	1	11701-052	SHAMPOO	100 mg	TOPICAL	OTC monograph not final	10 sections
Bedside-Care	HUMAN OTC DRUG LABEL	1	11701-053	SHAMPOO	100 mg	TOPICAL	OTC monograph not final	10 sections
Bedside-Care Perineal Wash	HUMAN OTC DRUG LABEL	1	11701-059	LIQUID	1 mL	TOPICAL	OTC monograph not final	10 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0128	LIQUID	0.20 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium Chloride and Dyclonine Hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0779	LIQUID	0.20 mg	TOPICAL	OTC monograph not final	15 sections
3 in 1 First Aid Wound Care	HUMAN OTC DRUG LABEL	1	11822-5074	SOLUTION	1.30 mg	TOPICAL	OTC monograph not final	14 sections
Mada MedicalFoam Sanitizer	HUMAN OTC DRUG LABEL	1	11928-682	LIQUID	0.20 mL	TOPICAL	OTC monograph not final	8 sections
QS Plus Instant Hand Sanitizer	HUMAN OTC DRUG LABEL	1	13302-575	LIQUID	2 mg	TOPICAL	OTC monograph not final	10 sections
QS Plus Hand Sanitizing Wipes	HUMAN OTC DRUG LABEL	1	13302-785	CLOTH	2 mg	TOPICAL	OTC monograph not final	10 sections
Veti-Foam	HUMAN OTC DRUG LABEL	1	13985-529	LIQUID	2 g	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
New Skin Bandage	HUMAN OTC DRUG LABEL	1	16864-440	LIQUID	1.80 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	15 sections
New Skin Bandage	HUMAN OTC DRUG LABEL	1	16864-450	SPRAY	60 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	15 sections
Dermoplast First Aid	HUMAN OTC DRUG LABEL	2	16864-670	SPRAY	2 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	15 sections
Wet Wipes	HUMAN OTC DRUG LABEL	1	20276-432	SWAB	0.30 mL	TOPICAL	OTC monograph not final	11 sections
Wet Wipes	HUMAN OTC DRUG LABEL	1	20276-433	SWAB	0.30 mL	TOPICAL	OTC monograph not final	11 sections
Saline Wound WashSignature Care	HUMAN OTC DRUG LABEL	1	21130-762	LIQUID	0.10 g	TOPICAL	OTC monograph not final	7 sections