povidone-iodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4249	25655-41-8

Description:

Molecule	Description
Synonyms: povidone-iodine povidone iodine iodine-povidone complex iodovidone proviodine	An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes. Molecular weight: Formula: I2(C6H9NO)n CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

povidone-iodine
povidone iodine
iodine-povidone complex
iodovidone
proviodine

An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.

Molecular weight:
Formula: I2(C6H9NO)n
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.20	g	V

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Nov. 29, 1985	FDA	BECTON DICKINSON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	888.98	23.84	150	4690	1415	50598869
Endophthalmitis	652.33	23.84	127	4713	2789	50597495
Hypopyon	250.28	23.84	45	4795	624	50599660
Corneal oedema	200.14	23.84	42	4798	1345	50598939
Drug hypersensitivity	187.02	23.84	169	4671	250841	50349443
Visual acuity reduced	173.16	23.84	67	4773	20072	50580212
Eye pain	134.91	23.84	62	4778	28387	50571897
Vitritis	128.91	23.84	27	4813	855	50599429
Anterior chamber cell	125.64	23.84	24	4816	470	50599814
Aqueous fibrin	122.47	23.84	18	4822	59	50600225
Retinopathy of prematurity	115.14	23.84	21	4819	316	50599968
Tonsillar ulcer	111.62	23.84	20	4820	271	50600013
Eye inflammation	104.17	23.84	31	4809	4177	50596107
Lower respiratory tract infection viral	95.06	23.84	20	4820	647	50599637
Anterior chamber fibrin	87.90	23.84	13	4827	45	50600239
Ocular hyperaemia	83.12	23.84	40	4800	20252	50580032
Intraocular pressure increased	79.85	23.84	27	4813	5489	50594795
Conjunctival oedema	78.67	23.84	17	4823	626	50599658
Lip ulceration	75.26	23.84	20	4820	1785	50598499
Punctate keratitis	69.68	23.84	15	4825	542	50599742
Vitreous floaters	69.08	23.84	24	4816	5290	50594994
Oliguria	65.83	23.84	26	4814	8190	50592094
Macular oedema	65.41	23.84	21	4819	3633	50596651
Corneal epithelium defect	65.12	23.84	13	4827	322	50599962
Post procedural discomfort	61.25	23.84	15	4825	965	50599319
Parophthalmia	59.93	23.84	12	4828	302	50599982
Tonsillitis	59.27	23.84	21	4819	4902	50595382
Visual impairment	56.47	23.84	49	4791	68226	50532058
Metamorphopsia	56.33	23.84	14	4826	957	50599327
Vision blurred	56.27	23.84	52	4788	78595	50521689
Procedural pain	52.82	23.84	26	4814	13806	50586478
Cataract nuclear	52.72	23.84	13	4827	860	50599424
Corneal abrasion	47.86	23.84	12	4828	850	50599434
Retinal haemorrhage	45.66	23.84	17	4823	4564	50595720
Eye irritation	42.10	23.84	24	4816	17116	50583168
Product contamination microbial	39.92	23.84	8	4832	202	50600082
Foetal non-stress test abnormal	38.31	23.84	6	4834	33	50600251
Cystoid macular oedema	37.65	23.84	11	4829	1388	50598896
Ophthalmological examination abnormal	34.15	23.84	6	4834	72	50600212
Eye oedema	33.69	23.84	10	4830	1333	50598951
Anterior chamber disorder	33.43	23.84	6	4834	82	50600202
Anaphylactic reaction	33.42	23.84	33	4807	54022	50546262
Suspected transmission of an infectious agent via product	33.07	23.84	7	4833	233	50600051
Retinal disorder	32.75	23.84	10	4830	1467	50598817
Cataract operation complication	31.42	23.84	6	4834	117	50600167
Vitreous detachment	30.83	23.84	10	4830	1784	50598500
Retinal scar	30.36	23.84	6	4834	141	50600143
Exophthalmos	30.02	23.84	9	4831	1241	50599043
Lacrimation increased	29.37	23.84	19	4821	16973	50583311
Post procedural complication	28.88	23.84	18	4822	15086	50585198
Off label use	28.84	23.84	105	4735	474321	50125963
Haematuria	28.78	23.84	22	4818	25591	50574693
Eyelid oedema	28.04	23.84	15	4825	9451	50590833
Conjunctivitis	27.78	23.84	18	4822	16127	50584157
Retinal pigment epithelial tear	27.28	23.84	6	4834	240	50600044
Streptococcal sepsis	27.26	23.84	9	4831	1698	50598586
Vitreous haemorrhage	27.05	23.84	9	4831	1739	50598545
Genital haemorrhage	27.02	23.84	13	4827	6561	50593723
Foreign body sensation in eyes	26.74	23.84	9	4831	1802	50598482
Blindness	26.67	23.84	18	4822	17251	50583033
Swollen tongue	26.62	23.84	22	4818	28608	50571676
Retinal oedema	26.54	23.84	7	4833	606	50599678
Bacterial endophthalmitis	26.39	23.84	4	4836	17	50600267
Enterocutaneous fistula	26.18	23.84	8	4832	1176	50599108
Lymphopenia	25.86	23.84	17	4823	15604	50584680
Iridocyclitis	25.65	23.84	9	4831	2040	50598244
Conjunctival hyperaemia	25.51	23.84	9	4831	2073	50598211
Pseudomonal sepsis	25.40	23.84	9	4831	2098	50598186
Vascular device infection	25.37	23.84	11	4829	4373	50595911
Corneal infiltrates	25.24	23.84	5	4835	119	50600165
Transmission of an infectious agent via product	24.49	23.84	5	4835	139	50600145
Procedural haemorrhage	24.29	23.84	9	4831	2381	50597903

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	459.39	29.96	81	2892	955	29570599
Endophthalmitis	458.25	29.96	95	2878	2753	29568801
Hypopyon	153.14	29.96	27	2946	315	29571239
Visual acuity reduced	148.88	29.96	56	2917	14820	29556734
Retinopathy of prematurity	139.00	29.96	21	2952	82	29571472
Corneal oedema	131.68	29.96	29	2944	1113	29570441
Vitritis	104.76	29.96	22	2951	671	29570883
Eye pain	102.85	29.96	40	2933	11555	29559999
Vision blurred	98.40	29.96	57	2916	40119	29531435
Vitreous floaters	98.20	29.96	28	2945	3093	29568461
Anterior chamber cell	91.34	29.96	17	2956	273	29571281
Eye inflammation	90.06	29.96	23	2950	1673	29569881
Anterior chamber fibrin	65.98	29.96	10	2963	40	29571514
Ocular hyperaemia	65.35	29.96	27	2946	9100	29562454
Aqueous fibrin	59.38	29.96	9	2964	36	29571518
Blindness	52.04	29.96	25	2948	11998	29559556
Visual impairment	49.42	29.96	33	2940	29675	29541879
Vitreous disorder	39.20	29.96	7	2966	88	29571466
Macular oedema	38.79	29.96	13	2960	2445	29569109
Eye irritation	37.36	29.96	16	2957	5882	29565672
Non-infectious endophthalmitis	36.24	29.96	7	2966	138	29571416
Anaphylactic reaction	35.07	29.96	26	2947	27547	29544007
Eye oedema	35.00	29.96	9	2964	671	29570883
Anterior chamber flare	34.33	29.96	6	2967	66	29571488
Vitreous detachment	33.88	29.96	9	2964	762	29570792
Metamorphopsia	32.59	29.96	8	2965	494	29571060
Retinal pigment epithelial tear	32.33	29.96	7	2966	247	29571307

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	1273.45	21.93	220	6453	2219	64489840
Endophthalmitis	969.14	21.93	198	6475	5167	64486892
Hypopyon	352.36	21.93	65	6608	964	64491095
Corneal oedema	310.24	21.93	67	6606	2276	64489783
Visual acuity reduced	257.21	21.93	99	6574	27042	64465017
Vitritis	220.82	21.93	47	6626	1486	64490573
Anterior chamber cell	212.42	21.93	41	6632	783	64491276
Aqueous fibrin	162.68	21.93	25	6648	108	64491951
Eye pain	144.96	21.93	69	6604	31556	64460503
Anterior chamber fibrin	141.97	21.93	23	6650	148	64491911
Eye inflammation	135.70	21.93	40	6633	4817	64487242
Ocular hyperaemia	118.16	21.93	54	6619	22510	64469549
Drug hypersensitivity	106.84	21.93	127	6546	237688	64254371
Tonsillar ulcer	102.76	21.93	20	6653	399	64491660
Vitreous floaters	92.97	21.93	32	6641	6341	64485718
Punctate keratitis	88.31	21.93	20	6653	845	64491214
Vision blurred	86.72	21.93	73	6600	90243	64401816
Lower respiratory tract infection viral	86.34	21.93	20	6653	935	64491124
Intraocular pressure increased	77.52	21.93	30	6643	8272	64483787
Lip ulceration	71.65	21.93	20	6653	1981	64490078
Visual impairment	71.34	21.93	60	6613	74017	64418042
Corneal epithelium defect	65.41	21.93	15	6658	670	64491389
Anaphylactic reaction	64.84	21.93	55	6618	68609	64423450
Macular oedema	61.64	21.93	22	6651	4845	64487214
Post procedural discomfort	61.29	21.93	15	6658	888	64491171
Retinal pigment epithelial tear	60.80	21.93	13	6660	419	64491640
Conjunctival oedema	58.85	21.93	15	6658	1049	64491010
Metamorphopsia	57.92	21.93	15	6658	1117	64490942
Tonsillitis	54.22	21.93	21	6652	5799	64486260
Procedural pain	53.72	21.93	28	6645	15480	64476579
Non-infectious endophthalmitis	53.43	21.93	11	6662	294	64491765
Post procedural complication	53.15	21.93	31	6642	21322	64470737
Corneal abrasion	50.64	21.93	13	6660	935	64491124
Blindness	49.67	21.93	30	6643	21989	64470070
Corneal infiltrates	48.30	21.93	10	6663	275	64491784
Parophthalmia	46.46	21.93	10	6663	333	64491726
Transmission of an infectious agent via product	46.26	21.93	9	6664	179	64491880
Suspected transmission of an infectious agent via product	46.16	21.93	12	6661	907	64491152
Retinal haemorrhage	46.06	21.93	20	6653	7378	64484681
Oliguria	43.96	21.93	24	6649	14552	64477507
Off label use	42.93	21.93	153	6520	632653	63859406
Eye oedema	42.59	21.93	13	6660	1760	64490299
Eye irritation	42.07	21.93	24	6649	15832	64476227
Product contamination microbial	41.80	21.93	11	6662	872	64491187
Anterior chamber flare	41.67	21.93	8	6665	148	64491911
Cataract nuclear	40.81	21.93	11	6662	956	64491103
Foreign body sensation in eyes	38.53	21.93	12	6661	1737	64490322
Vitreous disorder	37.91	21.93	8	6665	242	64491817
Urine iodine increased	37.42	21.93	5	6668	5	64492054
Vitreous detachment	37.28	21.93	12	6661	1932	64490127
Conjunctival hyperaemia	36.07	21.93	14	6659	3885	64488174
Ocular toxicity	35.20	21.93	9	6664	637	64491422
Post procedural infection	35.17	21.93	18	6655	9579	64482480
Eye pruritus	33.15	21.93	19	6654	12640	64479419
Eye infection bacterial	32.94	21.93	7	6666	219	64491840
Anterior chamber inflammation	32.37	21.93	8	6665	493	64491566
Vitreous opacities	32.24	21.93	8	6665	501	64491558
Vitreous haemorrhage	31.85	21.93	12	6661	3073	64488986
Conjunctivitis	31.76	21.93	22	6651	20332	64471727
Cataract operation complication	31.52	21.93	7	6666	270	64491789
Lacrimation increased	31.40	21.93	21	6652	18325	64473734
Cystoid macular oedema	30.17	21.93	10	6663	1764	64490295
Retinal disorder	30.05	21.93	10	6663	1786	64490273
Anterior chamber disorder	29.97	21.93	6	6667	139	64491920
Ocular hypertension	29.24	21.93	9	6664	1252	64490807
Pseudoendophthalmitis	29.09	21.93	5	6668	48	64492011
Retinal scar	29.03	21.93	7	6666	389	64491670
Retinal oedema	28.58	21.93	8	6665	800	64491259
Iridocyclitis	28.41	21.93	11	6662	3034	64489025
Genital haemorrhage	28.21	21.93	13	6660	5509	64486550
Poor quality product administered	27.83	21.93	11	6662	3204	64488855
Ophthalmological examination abnormal	27.70	21.93	5	6668	65	64491994
Corneal opacity	27.68	21.93	8	6665	897	64491162
Haemorrhoids thrombosed	27.61	21.93	6	6667	209	64491850
Exophthalmos	27.36	21.93	9	6664	1551	64490508
Maculopathy	26.83	21.93	10	6663	2486	64489573
Anaphylactic shock	25.98	21.93	23	6650	30305	64461754
Keratic precipitates	25.54	21.93	6	6667	298	64491761
Photophobia	25.36	21.93	18	6655	17275	64474784
Delayed delivery	25.07	21.93	4	6669	23	64492036
Balanitis candida	24.80	21.93	5	6668	120	64491939
Photopsia	23.77	21.93	11	6662	4703	64487356
Retinal detachment	23.68	21.93	13	6660	7963	64484096
Dermatitis bullous	23.57	21.93	15	6658	12039	64480020
Enterocutaneous fistula	23.41	21.93	8	6665	1549	64490510
Fatigue	22.20	21.93	27	6646	748703	63743356
Device expulsion	22.15	21.93	18	6655	21118	64470941
Cardiac pacemaker removal	21.99	21.93	3	6670	4	64492055

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AG02	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Iodine products
ATC	D09AA09	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	D11AC06	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Medicated shampoos
ATC	G01AX11	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Other antiinfectives and antiseptics
ATC	R02AA15	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
ATC	S01AX18	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Other antiinfectives
FDA CS	M0011640	Iodine
FDA EPC	N0000175486	Antiseptic
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Bacterial septicemia	contraindication	10001005	DOID:0040085
Shock	contraindication	27942005
Decreased respiratory function	contraindication	80954004
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Heart block	contraindication	233916004
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Denuded skin	contraindication	418242004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019273	VUID
N0000147472	NUI
D00863	KEGG_DRUG
4018171	VANDF
4019273	VANDF
C0032857	UMLSCUI
CHEBI:8347	CHEBI
CHEMBL1201724	ChEMBL_ID
D011206	MESH_DESCRIPTOR_UI
DB06812	DRUGBANK_ID
85H0HZU99M	UNII
410087	PUBCHEM_CID
8611	RXNORM
1871	MMSL
5338	MMSL
003153	NDDF
111144003	SNOMEDCT_US
386989006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Betadine	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0411	SOLUTION	5 mg	OPHTHALMIC	NDA	16 sections
SUMMERS EVE	HUMAN OTC DRUG LABEL	1	0132-8743	DOUCHE	4 g	VAGINAL	OTC MONOGRAPH NOT FINAL	12 sections
First Aid Antiseptic	HUMAN OTC DRUG LABEL	1	0363-0777	SOLUTION	10 mg	TOPICAL	OTC monograph not final	13 sections
Apothecary PVP Topical	HUMAN OTC DRUG LABEL	1	0363-0939	SOLUTION	1 g	TOPICAL	OTC monograph not final	11 sections
Humco Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-2325	LIQUID	100 mg	TOPICAL	OTC monograph not final	13 sections
Humco Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-2325	LIQUID	100 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9123	LIQUID	100 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9123	LIQUID	100 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9128	LIQUID	5 mg	TOPICAL	OTC monograph not final	14 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9128	LIQUID	5 mg	TOPICAL	OTC monograph not final	14 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9129	LIQUID	50 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9129	LIQUID	50 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9136	LIQUID	5 mg	TOPICAL	OTC monograph not final	14 sections
Povidone Iodine	HUMAN OTC DRUG LABEL	1	0395-9136	LIQUID	5 mg	TOPICAL	OTC monograph not final	14 sections
Henry Schein Povidone-Iodine Swabsticks	HUMAN OTC DRUG LABEL	1	0404-0119	SWAB	1 g	TOPICAL	OTC monograph not final	13 sections
Henry Schein Povidone-Iodine Prep Pad	HUMAN OTC DRUG LABEL	1	0404-0121	SWAB	1 g	TOPICAL	OTC monograph not final	10 sections
povidine iodine	HUMAN OTC DRUG LABEL	1	0404-5637	SWAB	10 mL	TOPICAL	OTC monograph final	11 sections
povidine iodine	HUMAN OTC DRUG LABEL	1	0404-5638	SWAB	10 mL	TOPICAL	OTC monograph final	11 sections
povidine iodine	HUMAN OTC DRUG LABEL	1	0404-5639	SWAB	10 mL	TOPICAL	OTC monograph final	11 sections
North PVP Iodine Swabs	HUMAN OTC DRUG LABEL	1	0498-0118	SOLUTION	0.01 g	TOPICAL	unapproved drug other	14 sections
North PVP Iodine Wipe	HUMAN OTC DRUG LABEL	1	0498-0120	SWAB	10 mg	TOPICAL	unapproved drug other	12 sections
PVP Iodine Wipe	HUMAN OTC DRUG LABEL	1	0498-0121	SWAB	10 mg	TOPICAL	unapproved drug other	12 sections
PVP Iodine Swabs	HUMAN OTC DRUG LABEL	1	0498-0128	SOLUTION	0.01 g	TOPICAL	unapproved drug other	14 sections
First Aid Antiseptic	HUMAN OTC DRUG LABEL	1	0536-1271	OINTMENT	100 mg	TOPICAL	OTC monograph not final	13 sections
Povidone Iodine Solution First Aid Antiseptic	HUMAN OTC DRUG LABEL	1	0869-0050	SOLUTION	10.34 mg	TOPICAL	OTC monograph not final	14 sections
Povidone Iodine Solution First Aid Antiseptic	HUMAN OTC DRUG LABEL	1	0869-0050	SOLUTION	10.34 mg	TOPICAL	OTC monograph not final	14 sections
Major Povidone Iodine	HUMAN OTC DRUG LABEL	1	0904-1102	OINTMENT	100 mg	TOPICAL	OTC monograph final	14 sections
povidone iodine	HUMAN OTC DRUG LABEL	1	0904-1103	SOLUTION	100 mg	TOPICAL	OTC monograph final	11 sections
First Aid Only Povidone-Iodine Prep Pad	HUMAN OTC DRUG LABEL	1	0924-8110	PATCH	10 g	TOPICAL	OTC monograph not final	9 sections
First Aid Only Povidone-Iodine Antiseptic	HUMAN OTC DRUG LABEL	1	0924-8112	SWAB	1 g	TOPICAL	OTC monograph not final	12 sections