povidone-iodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
radiopharmaceuticals, iodine-contained 4249 25655-41-8

Description:

MoleculeDescription

Synonyms:

  • povidone-iodine
  • povidone iodine
  • iodine-povidone complex
  • iodovidone
  • proviodine
An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.
  • Molecular weight:
  • Formula: I2(C6H9NO)n
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.20 g V

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 29, 1985 FDA BECTON DICKINSON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 920.41 23.72 154 5081 1617 63482170
Endophthalmitis 780.32 23.72 149 5086 3443 63480344
Hypopyon 259.52 23.72 46 5189 686 63483101
Corneal oedema 203.25 23.72 42 5193 1451 63482336
Visual acuity reduced 188.51 23.72 70 5165 21756 63462031
Drug hypersensitivity 185.15 23.72 173 5062 310514 63173273
Eye pain 136.48 23.72 63 5172 33791 63449996
Vitritis 135.56 23.72 28 5207 964 63482823
Anterior chamber cell 126.88 23.72 24 5211 520 63483267
Aqueous fibrin 125.13 23.72 18 5217 59 63483728
Tonsillar ulcer 120.48 23.72 21 5214 282 63483505
Retinopathy of prematurity 116.93 23.72 21 5214 338 63483449
Eye inflammation 104.19 23.72 32 5203 5567 63478220
Lower respiratory tract infection viral 97.19 23.72 21 5214 900 63482887
Anterior chamber fibrin 89.82 23.72 13 5222 45 63483742
Intraocular pressure increased 81.21 23.72 27 5208 6051 63477736
Ocular hyperaemia 80.60 23.72 40 5195 25104 63458683
Lip ulceration 80.48 23.72 21 5214 2029 63481758
Conjunctival oedema 79.69 23.72 17 5218 685 63483102
Punctate keratitis 70.27 23.72 15 5220 606 63483181
Vitreous floaters 69.84 23.72 24 5211 5942 63477845
Macular oedema 67.25 23.72 21 5214 3856 63479931
Oliguria 66.99 23.72 26 5209 9075 63474712
Corneal epithelium defect 66.41 23.72 13 5222 339 63483448
Bacterial endophthalmitis 66.17 23.72 11 5224 109 63483678
Tonsillitis 63.00 23.72 22 5213 5713 63478074
Post procedural discomfort 61.55 23.72 15 5220 1099 63482688
Parophthalmia 61.37 23.72 12 5223 311 63483476
Vision blurred 57.85 23.72 53 5182 91871 63391916
Metamorphopsia 55.88 23.72 14 5221 1149 63482638
Cataract nuclear 53.89 23.72 13 5222 912 63482875
Procedural pain 53.80 23.72 29 5206 21540 63462247
Visual impairment 53.74 23.72 49 5186 84397 63399390
Retinal haemorrhage 46.77 23.72 17 5218 4952 63478835
Corneal abrasion 46.47 23.72 12 5223 1112 63482675
Product contamination microbial 40.77 23.72 8 5227 211 63483576
Eye irritation 39.87 23.72 24 5211 21947 63461840
Foetal non-stress test abnormal 39.04 23.72 6 5229 34 63483753
Cystoid macular oedema 37.97 23.72 11 5224 1564 63482223
Anaphylactic reaction 37.50 23.72 36 5199 66064 63417723
Ophthalmological examination abnormal 35.04 23.72 6 5229 72 63483715
Eye oedema 33.93 23.72 10 5225 1510 63482277
Conjunctivitis 33.36 23.72 21 5214 20775 63463012
Off label use 33.15 23.72 126 5109 674336 62809451
Retinal disorder 32.88 23.72 10 5225 1680 63482107
Suspected transmission of an infectious agent via product 32.50 23.72 7 5228 295 63483492
Anterior chamber disorder 32.03 23.72 6 5229 123 63483664
Cataract operation complication 31.54 23.72 6 5229 134 63483653
Streptococcal sepsis 31.49 23.72 10 5225 1936 63481851
Retinal scar 31.12 23.72 6 5229 144 63483643
Vitreous detachment 31.09 23.72 10 5225 2017 63481770
Vitreous haemorrhage 30.98 23.72 10 5225 2040 63481747
Genital haemorrhage 30.61 23.72 14 5221 7318 63476469
Multiple use of single-use product 29.76 23.72 9 5226 1483 63482304
Exophthalmos 29.62 23.72 9 5226 1507 63482280
Blindness unilateral 29.51 23.72 13 5222 6228 63477559
Pseudomonal sepsis 29.43 23.72 10 5225 2391 63481396
Post procedural complication 29.30 23.72 18 5217 17056 63466731
Haematuria 29.15 23.72 22 5213 29135 63454652
Iridocyclitis 28.95 23.72 10 5225 2512 63481275
Eyelid oedema 28.70 23.72 15 5220 10464 63473323
Lacrimation increased 28.58 23.72 19 5216 20612 63463175
Retinal pigment epithelial tear 27.85 23.72 6 5229 253 63483534
Swollen tongue 27.78 23.72 23 5212 34777 63449010
Photopsia 26.64 23.72 11 5224 4498 63479289
Retinal oedema 26.64 23.72 7 5228 694 63483093
Foreign body sensation in eyes 26.19 23.72 9 5226 2225 63481562
Enterocutaneous fistula 26.05 23.72 8 5227 1389 63482398
Lymphopenia 25.68 23.72 17 5218 18310 63465477
Conjunctival hyperaemia 25.64 23.72 9 5226 2370 63481417
Blindness 25.37 23.72 18 5217 21681 63462106
Corneal infiltrates 25.30 23.72 5 5230 137 63483650
Transmission of an infectious agent via product 24.99 23.72 5 5230 146 63483641
Procedural haemorrhage 24.56 23.72 9 5226 2679 63481108
Vascular device infection 24.51 23.72 12 5223 7300 63476487
Delayed delivery 24.31 23.72 4 5231 37 63483750

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Endophthalmitis 542.59 26.36 112 3185 3396 34950238
Toxic anterior segment syndrome 467.94 26.36 83 3214 1086 34952548
Hypopyon 157.51 26.36 28 3269 368 34953266
Visual acuity reduced 147.83 26.36 56 3241 16093 34937541
Corneal oedema 139.59 26.36 31 3266 1320 34952314
Retinopathy of prematurity 130.82 26.36 21 3276 141 34953493
Eye pain 106.48 26.36 42 3255 13420 34940214
Vitritis 106.24 26.36 23 3274 868 34952766
Vision blurred 97.21 26.36 58 3239 45905 34907729
Vitreous floaters 96.12 26.36 28 3269 3557 34950077
Anterior chamber cell 94.27 26.36 18 3279 357 34953277
Eye inflammation 85.39 26.36 23 3274 2195 34951439
Aqueous fibrin 66.61 26.36 10 3287 40 34953594
Anterior chamber fibrin 65.85 26.36 10 3287 44 34953590
Ocular hyperaemia 61.09 26.36 27 3270 11425 34942209
Blindness 54.16 26.36 27 3270 14959 34938675
Visual impairment 48.04 26.36 34 3263 35768 34917866
Anaphylactic reaction 46.43 26.36 32 3265 32269 34921365
Vitreous disorder 39.21 26.36 7 3290 94 34953540
Anaphylactic shock 38.60 26.36 22 3275 15919 34937715
Macular oedema 37.43 26.36 13 3284 2901 34950733
Non-infectious endophthalmitis 36 26.36 7 3290 153 34953481
Eye irritation 34.52 26.36 16 3281 7545 34946089
Anterior chamber flare 34.01 26.36 6 3291 75 34953559
Eye oedema 33.77 26.36 9 3288 823 34952811
Vitreous detachment 33.19 26.36 9 3288 879 34952755
Metamorphopsia 32.68 26.36 8 3289 521 34953113
Retinal pigment epithelial tear 32.02 26.36 7 3290 276 34953358
Urine iodine increased 29.84 26.36 4 3293 5 34953629
Off label use 29.15 26.36 96 3201 419428 34534206
Diabetic retinal oedema 28.75 26.36 6 3291 189 34953445
Haemorrhoids thrombosed 28.42 26.36 6 3291 200 34953434
Toxic skin eruption 28.33 26.36 16 3281 11369 34942265
Retinal haemorrhage 27.13 26.36 12 3285 5077 34948557

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 1310.69 20.93 226 7161 2538 79734463
Endophthalmitis 1168.18 20.93 234 7153 6194 79730807
Hypopyon 365.63 20.93 67 7320 1075 79735926
Corneal oedema 321.42 20.93 69 7318 2551 79734450
Visual acuity reduced 270.72 20.93 102 7285 29367 79707634
Vitritis 229.97 20.93 49 7338 1745 79735256
Anterior chamber cell 217.31 20.93 42 7345 907 79736094
Aqueous fibrin 172.12 20.93 26 7361 112 79736889
Eye pain 149.91 20.93 72 7315 37506 79699495
Anterior chamber fibrin 143.85 20.93 23 7364 153 79736848
Eye inflammation 133.31 20.93 41 7346 6372 79730629
Ocular hyperaemia 112.33 20.93 54 7333 28152 79708849
Tonsillar ulcer 110.64 20.93 21 7366 410 79736591
Drug hypersensitivity 99.45 20.93 130 7257 298786 79438215
Vitreous floaters 92.36 20.93 32 7355 7224 79729777
Lower respiratory tract infection viral 88.86 20.93 21 7366 1199 79735802
Punctate keratitis 87.90 20.93 20 7367 966 79736035
Vision blurred 87.66 20.93 75 7312 105823 79631178
Intraocular pressure increased 84.92 20.93 32 7355 9173 79727828
Bacterial endophthalmitis 80.29 20.93 14 7373 166 79736835
Anaphylactic reaction 79.03 20.93 64 7323 83679 79653322
Lip ulceration 75.42 20.93 21 7366 2304 79734697
Corneal epithelium defect 66.34 20.93 15 7372 704 79736297
Visual impairment 65.73 20.93 60 7327 92071 79644930
Procedural pain 65.05 20.93 35 7352 23049 79713952
Macular oedema 61.48 20.93 22 7365 5452 79731549
Retinal pigment epithelial tear 60.98 20.93 13 7374 463 79736538
Post procedural discomfort 60.83 20.93 15 7372 1025 79735976
Conjunctival oedema 59.23 20.93 15 7372 1143 79735858
Metamorphopsia 57.59 20.93 15 7372 1278 79735723
Tonsillitis 57.10 20.93 22 7365 6692 79730309
Non-infectious endophthalmitis 53.75 20.93 11 7376 320 79736681
Post procedural complication 53.17 20.93 31 7356 23798 79713203
Off label use 51.48 20.93 192 7195 907023 78829978
Blindness 50.66 20.93 32 7355 28351 79708650
Retinal haemorrhage 49.46 20.93 21 7366 8196 79728805
Corneal abrasion 48.61 20.93 13 7374 1226 79735775
Corneal infiltrates 48.56 20.93 10 7377 300 79736701
Anaphylactic shock 48.35 20.93 34 7353 35962 79701039
Transmission of an infectious agent via product 46.65 20.93 9 7378 192 79736809
Parophthalmia 46.10 20.93 10 7377 387 79736614
Suspected transmission of an infectious agent via product 44.44 20.93 12 7375 1174 79735827
Oliguria 43.92 20.93 24 7363 16285 79720716
Product contamination microbial 42.25 20.93 11 7376 935 79736066
Anterior chamber flare 42.10 20.93 8 7379 157 79736844
Eye oedema 42.06 20.93 13 7374 2050 79734951
Cataract nuclear 41.16 20.93 11 7376 1035 79735966
Eye irritation 38.62 20.93 24 7363 20657 79716344
Conjunctivitis 38.56 20.93 26 7361 25689 79711312
Vitreous disorder 38.44 20.93 8 7379 253 79736748
Urine iodine increased 37.97 20.93 5 7382 5 79736996
Multiple use of single-use product 37.70 20.93 10 7377 914 79736087
Foreign body sensation in eyes 37.35 20.93 12 7375 2145 79734856
Ocular hypertension 37.09 20.93 11 7376 1509 79735492
Toxic skin eruption 36.97 20.93 24 7363 22269 79714732
Vitreous detachment 36.81 20.93 12 7375 2247 79734754
Conjunctival hyperaemia 35.89 20.93 14 7373 4399 79732602
Iridocyclitis 34.60 20.93 13 7374 3691 79733310
Vitreous haemorrhage 34.57 20.93 13 7374 3700 79733301
Post procedural infection 34.15 20.93 18 7369 11366 79725635
Ocular toxicity 33.41 20.93 9 7378 872 79736129
Anterior chamber inflammation 32.17 20.93 8 7379 566 79736435
Cataract operation complication 31.71 20.93 7 7380 294 79736707
Genital haemorrhage 31.18 20.93 14 7373 6241 79730760
Vitreous opacities 30.88 20.93 8 7379 667 79736334
Blindness unilateral 30.61 20.93 15 7372 8131 79728870
Eye infection bacterial 30.29 20.93 7 7380 362 79736639
Cystoid macular oedema 30.18 20.93 10 7377 1970 79735031
Anterior chamber disorder 29.96 20.93 6 7381 156 79736845
Retinal disorder 29.85 20.93 10 7377 2037 79734964
Lacrimation increased 29.64 20.93 21 7366 22456 79714545
Pseudoendophthalmitis 29.45 20.93 5 7382 50 79736951
Retinal scar 29.26 20.93 7 7380 421 79736580
Swollen tongue 28.92 20.93 27 7360 42543 79694458
Ophthalmological examination abnormal 28.25 20.93 5 7382 65 79736936
Retinal oedema 28.05 20.93 8 7379 957 79736044
Poor quality product administered 27.67 20.93 11 7376 3634 79733367
Corneal opacity 27.61 20.93 8 7379 1012 79735989
Exophthalmos 27.42 20.93 9 7378 1721 79735280
Haemorrhoids thrombosed 27.30 20.93 6 7381 247 79736754
Photopsia 26.78 20.93 12 7375 5324 79731677
Maculopathy 26.70 20.93 10 7377 2815 79734186
Eye pruritus 26.62 20.93 19 7368 20551 79716450
Delayed delivery 25.51 20.93 4 7383 23 79736978
Balanitis candida 25.31 20.93 5 7382 121 79736880
Keratic precipitates 25.14 20.93 6 7381 357 79736644
Device expulsion 24.86 20.93 20 7367 25841 79711160
Photophobia 24.38 20.93 18 7369 20510 79716491
Fatigue 23.66 20.93 31 7356 929696 78807305
Retinal detachment 23.22 20.93 13 7374 9234 79727767
Dermatitis bullous 22.79 20.93 15 7372 14230 79722771
Enterocutaneous fistula 22.47 20.93 8 7379 1953 79735048
Retinopathy of prematurity 21.57 20.93 3 7384 6 79736995
Ocular discomfort 21.22 20.93 10 7377 4973 79732028
Macular fibrosis 21.04 20.93 6 7381 717 79736284

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AG02 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
ATC D09AA09 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC D11AC06 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Medicated shampoos
ATC G01AX11 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Other antiinfectives and antiseptics
ATC R02AA15 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
ATC S01AX18 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Other antiinfectives
FDA CS M0011640 Iodine
FDA EPC N0000175486 Antiseptic
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bacterial septicemia contraindication 10001005 DOID:0040085
Shock contraindication 27942005
Decreased respiratory function contraindication 80954004
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019273 VUID
N0000147472 NUI
D00863 KEGG_DRUG
4018171 VANDF
4019273 VANDF
C0032857 UMLSCUI
CHEBI:8347 CHEBI
CHEMBL1201724 ChEMBL_ID
D011206 MESH_DESCRIPTOR_UI
DB06812 DRUGBANK_ID
85H0HZU99M UNII
410087 PUBCHEM_CID
8611 RXNORM
1871 MMSL
5338 MMSL
003153 NDDF
111144003 SNOMEDCT_US
386989006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Betadine HUMAN PRESCRIPTION DRUG LABEL 1 0065-0411 SOLUTION 5 mg OPHTHALMIC NDA 16 sections
Betadine HUMAN PRESCRIPTION DRUG LABEL 1 0065-0411 SOLUTION 5 mg OPHTHALMIC NDA 16 sections
SUMMERS EVE HUMAN OTC DRUG LABEL 1 0132-8743 DOUCHE 4 g VAGINAL OTC MONOGRAPH NOT FINAL 12 sections
SUMMERS EVE HUMAN OTC DRUG LABEL 1 0132-8743 DOUCHE 4 g VAGINAL OTC MONOGRAPH NOT FINAL 12 sections
First Aid Antiseptic HUMAN OTC DRUG LABEL 1 0363-0777 SOLUTION 10 mg TOPICAL OTC monograph not final 13 sections
First Aid Antiseptic HUMAN OTC DRUG LABEL 1 0363-0777 SOLUTION 10 mg TOPICAL OTC monograph not final 13 sections
Apothecary PVP Topical HUMAN OTC DRUG LABEL 1 0363-0939 SOLUTION 1 g TOPICAL OTC monograph not final 11 sections
Humco Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-2325 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
Humco Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-2325 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9123 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9123 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9128 LIQUID 5 mg TOPICAL OTC monograph not final 14 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9128 LIQUID 5 mg TOPICAL OTC monograph not final 14 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9128 LIQUID 5 mg TOPICAL OTC monograph not final 14 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9129 LIQUID 50 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9129 LIQUID 50 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9129 LIQUID 50 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9136 LIQUID 5 mg TOPICAL OTC monograph not final 14 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9136 LIQUID 5 mg TOPICAL OTC monograph not final 14 sections
Henry Schein Povidone-Iodine Swabsticks HUMAN OTC DRUG LABEL 1 0404-0119 SWAB 1 g TOPICAL OTC monograph not final 13 sections
Henry Schein Povidone-Iodine Prep Pad HUMAN OTC DRUG LABEL 1 0404-0121 SWAB 1 g TOPICAL OTC monograph not final 10 sections
povidine iodine HUMAN OTC DRUG LABEL 1 0404-5637 SWAB 10 mL TOPICAL OTC monograph final 11 sections
povidine iodine HUMAN OTC DRUG LABEL 1 0404-5638 SWAB 10 mL TOPICAL OTC monograph final 11 sections
povidine iodine HUMAN OTC DRUG LABEL 1 0404-5639 SWAB 10 mL TOPICAL OTC monograph final 11 sections
North PVP Iodine Swabs HUMAN OTC DRUG LABEL 1 0498-0118 SOLUTION 0.01 g TOPICAL unapproved drug other 14 sections
North PVP Iodine Swabs HUMAN OTC DRUG LABEL 1 0498-0118 SOLUTION 0.01 g TOPICAL unapproved drug other 14 sections
North PVP Iodine Wipe HUMAN OTC DRUG LABEL 1 0498-0120 SWAB 10 mg TOPICAL unapproved drug other 12 sections
North PVP Iodine Wipe HUMAN OTC DRUG LABEL 1 0498-0120 SWAB 10 mg TOPICAL unapproved drug other 12 sections
PVP Iodine Wipe HUMAN OTC DRUG LABEL 1 0498-0121 SWAB 10 mg TOPICAL unapproved drug other 12 sections
PVP Iodine Wipe HUMAN OTC DRUG LABEL 1 0498-0121 SWAB 10 mg TOPICAL unapproved drug other 12 sections