povidone-iodine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4249 25655-41-8

Description:

MoleculeDescription

Synonyms:

  • povidone-iodine
  • povidone iodine
  • iodine-povidone complex
  • iodovidone
  • proviodine
An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.
  • Molecular weight:
  • Formula: I2(C6H9NO)n
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.20 g V

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 29, 1985 FDA BECTON DICKINSON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 888.98 23.84 150 4690 1415 50598869
Endophthalmitis 652.33 23.84 127 4713 2789 50597495
Hypopyon 250.28 23.84 45 4795 624 50599660
Corneal oedema 200.14 23.84 42 4798 1345 50598939
Drug hypersensitivity 187.02 23.84 169 4671 250841 50349443
Visual acuity reduced 173.16 23.84 67 4773 20072 50580212
Eye pain 134.91 23.84 62 4778 28387 50571897
Vitritis 128.91 23.84 27 4813 855 50599429
Anterior chamber cell 125.64 23.84 24 4816 470 50599814
Aqueous fibrin 122.47 23.84 18 4822 59 50600225
Retinopathy of prematurity 115.14 23.84 21 4819 316 50599968
Tonsillar ulcer 111.62 23.84 20 4820 271 50600013
Eye inflammation 104.17 23.84 31 4809 4177 50596107
Lower respiratory tract infection viral 95.06 23.84 20 4820 647 50599637
Anterior chamber fibrin 87.90 23.84 13 4827 45 50600239
Ocular hyperaemia 83.12 23.84 40 4800 20252 50580032
Intraocular pressure increased 79.85 23.84 27 4813 5489 50594795
Conjunctival oedema 78.67 23.84 17 4823 626 50599658
Lip ulceration 75.26 23.84 20 4820 1785 50598499
Punctate keratitis 69.68 23.84 15 4825 542 50599742
Vitreous floaters 69.08 23.84 24 4816 5290 50594994
Oliguria 65.83 23.84 26 4814 8190 50592094
Macular oedema 65.41 23.84 21 4819 3633 50596651
Corneal epithelium defect 65.12 23.84 13 4827 322 50599962
Post procedural discomfort 61.25 23.84 15 4825 965 50599319
Parophthalmia 59.93 23.84 12 4828 302 50599982
Tonsillitis 59.27 23.84 21 4819 4902 50595382
Visual impairment 56.47 23.84 49 4791 68226 50532058
Metamorphopsia 56.33 23.84 14 4826 957 50599327
Vision blurred 56.27 23.84 52 4788 78595 50521689
Procedural pain 52.82 23.84 26 4814 13806 50586478
Cataract nuclear 52.72 23.84 13 4827 860 50599424
Corneal abrasion 47.86 23.84 12 4828 850 50599434
Retinal haemorrhage 45.66 23.84 17 4823 4564 50595720
Eye irritation 42.10 23.84 24 4816 17116 50583168
Product contamination microbial 39.92 23.84 8 4832 202 50600082
Foetal non-stress test abnormal 38.31 23.84 6 4834 33 50600251
Cystoid macular oedema 37.65 23.84 11 4829 1388 50598896
Ophthalmological examination abnormal 34.15 23.84 6 4834 72 50600212
Eye oedema 33.69 23.84 10 4830 1333 50598951
Anterior chamber disorder 33.43 23.84 6 4834 82 50600202
Anaphylactic reaction 33.42 23.84 33 4807 54022 50546262
Suspected transmission of an infectious agent via product 33.07 23.84 7 4833 233 50600051
Retinal disorder 32.75 23.84 10 4830 1467 50598817
Cataract operation complication 31.42 23.84 6 4834 117 50600167
Vitreous detachment 30.83 23.84 10 4830 1784 50598500
Retinal scar 30.36 23.84 6 4834 141 50600143
Exophthalmos 30.02 23.84 9 4831 1241 50599043
Lacrimation increased 29.37 23.84 19 4821 16973 50583311
Post procedural complication 28.88 23.84 18 4822 15086 50585198
Off label use 28.84 23.84 105 4735 474321 50125963
Haematuria 28.78 23.84 22 4818 25591 50574693
Eyelid oedema 28.04 23.84 15 4825 9451 50590833
Conjunctivitis 27.78 23.84 18 4822 16127 50584157
Retinal pigment epithelial tear 27.28 23.84 6 4834 240 50600044
Streptococcal sepsis 27.26 23.84 9 4831 1698 50598586
Vitreous haemorrhage 27.05 23.84 9 4831 1739 50598545
Genital haemorrhage 27.02 23.84 13 4827 6561 50593723
Foreign body sensation in eyes 26.74 23.84 9 4831 1802 50598482
Blindness 26.67 23.84 18 4822 17251 50583033
Swollen tongue 26.62 23.84 22 4818 28608 50571676
Retinal oedema 26.54 23.84 7 4833 606 50599678
Bacterial endophthalmitis 26.39 23.84 4 4836 17 50600267
Enterocutaneous fistula 26.18 23.84 8 4832 1176 50599108
Lymphopenia 25.86 23.84 17 4823 15604 50584680
Iridocyclitis 25.65 23.84 9 4831 2040 50598244
Conjunctival hyperaemia 25.51 23.84 9 4831 2073 50598211
Pseudomonal sepsis 25.40 23.84 9 4831 2098 50598186
Vascular device infection 25.37 23.84 11 4829 4373 50595911
Corneal infiltrates 25.24 23.84 5 4835 119 50600165
Transmission of an infectious agent via product 24.49 23.84 5 4835 139 50600145
Procedural haemorrhage 24.29 23.84 9 4831 2381 50597903

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 459.39 29.96 81 2892 955 29570599
Endophthalmitis 458.25 29.96 95 2878 2753 29568801
Hypopyon 153.14 29.96 27 2946 315 29571239
Visual acuity reduced 148.88 29.96 56 2917 14820 29556734
Retinopathy of prematurity 139.00 29.96 21 2952 82 29571472
Corneal oedema 131.68 29.96 29 2944 1113 29570441
Vitritis 104.76 29.96 22 2951 671 29570883
Eye pain 102.85 29.96 40 2933 11555 29559999
Vision blurred 98.40 29.96 57 2916 40119 29531435
Vitreous floaters 98.20 29.96 28 2945 3093 29568461
Anterior chamber cell 91.34 29.96 17 2956 273 29571281
Eye inflammation 90.06 29.96 23 2950 1673 29569881
Anterior chamber fibrin 65.98 29.96 10 2963 40 29571514
Ocular hyperaemia 65.35 29.96 27 2946 9100 29562454
Aqueous fibrin 59.38 29.96 9 2964 36 29571518
Blindness 52.04 29.96 25 2948 11998 29559556
Visual impairment 49.42 29.96 33 2940 29675 29541879
Vitreous disorder 39.20 29.96 7 2966 88 29571466
Macular oedema 38.79 29.96 13 2960 2445 29569109
Eye irritation 37.36 29.96 16 2957 5882 29565672
Non-infectious endophthalmitis 36.24 29.96 7 2966 138 29571416
Anaphylactic reaction 35.07 29.96 26 2947 27547 29544007
Eye oedema 35.00 29.96 9 2964 671 29570883
Anterior chamber flare 34.33 29.96 6 2967 66 29571488
Vitreous detachment 33.88 29.96 9 2964 762 29570792
Metamorphopsia 32.59 29.96 8 2965 494 29571060
Retinal pigment epithelial tear 32.33 29.96 7 2966 247 29571307

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 1273.45 21.93 220 6453 2219 64489840
Endophthalmitis 969.14 21.93 198 6475 5167 64486892
Hypopyon 352.36 21.93 65 6608 964 64491095
Corneal oedema 310.24 21.93 67 6606 2276 64489783
Visual acuity reduced 257.21 21.93 99 6574 27042 64465017
Vitritis 220.82 21.93 47 6626 1486 64490573
Anterior chamber cell 212.42 21.93 41 6632 783 64491276
Aqueous fibrin 162.68 21.93 25 6648 108 64491951
Eye pain 144.96 21.93 69 6604 31556 64460503
Anterior chamber fibrin 141.97 21.93 23 6650 148 64491911
Eye inflammation 135.70 21.93 40 6633 4817 64487242
Ocular hyperaemia 118.16 21.93 54 6619 22510 64469549
Drug hypersensitivity 106.84 21.93 127 6546 237688 64254371
Tonsillar ulcer 102.76 21.93 20 6653 399 64491660
Vitreous floaters 92.97 21.93 32 6641 6341 64485718
Punctate keratitis 88.31 21.93 20 6653 845 64491214
Vision blurred 86.72 21.93 73 6600 90243 64401816
Lower respiratory tract infection viral 86.34 21.93 20 6653 935 64491124
Intraocular pressure increased 77.52 21.93 30 6643 8272 64483787
Lip ulceration 71.65 21.93 20 6653 1981 64490078
Visual impairment 71.34 21.93 60 6613 74017 64418042
Corneal epithelium defect 65.41 21.93 15 6658 670 64491389
Anaphylactic reaction 64.84 21.93 55 6618 68609 64423450
Macular oedema 61.64 21.93 22 6651 4845 64487214
Post procedural discomfort 61.29 21.93 15 6658 888 64491171
Retinal pigment epithelial tear 60.80 21.93 13 6660 419 64491640
Conjunctival oedema 58.85 21.93 15 6658 1049 64491010
Metamorphopsia 57.92 21.93 15 6658 1117 64490942
Tonsillitis 54.22 21.93 21 6652 5799 64486260
Procedural pain 53.72 21.93 28 6645 15480 64476579
Non-infectious endophthalmitis 53.43 21.93 11 6662 294 64491765
Post procedural complication 53.15 21.93 31 6642 21322 64470737
Corneal abrasion 50.64 21.93 13 6660 935 64491124
Blindness 49.67 21.93 30 6643 21989 64470070
Corneal infiltrates 48.30 21.93 10 6663 275 64491784
Parophthalmia 46.46 21.93 10 6663 333 64491726
Transmission of an infectious agent via product 46.26 21.93 9 6664 179 64491880
Suspected transmission of an infectious agent via product 46.16 21.93 12 6661 907 64491152
Retinal haemorrhage 46.06 21.93 20 6653 7378 64484681
Oliguria 43.96 21.93 24 6649 14552 64477507
Off label use 42.93 21.93 153 6520 632653 63859406
Eye oedema 42.59 21.93 13 6660 1760 64490299
Eye irritation 42.07 21.93 24 6649 15832 64476227
Product contamination microbial 41.80 21.93 11 6662 872 64491187
Anterior chamber flare 41.67 21.93 8 6665 148 64491911
Cataract nuclear 40.81 21.93 11 6662 956 64491103
Foreign body sensation in eyes 38.53 21.93 12 6661 1737 64490322
Vitreous disorder 37.91 21.93 8 6665 242 64491817
Urine iodine increased 37.42 21.93 5 6668 5 64492054
Vitreous detachment 37.28 21.93 12 6661 1932 64490127
Conjunctival hyperaemia 36.07 21.93 14 6659 3885 64488174
Ocular toxicity 35.20 21.93 9 6664 637 64491422
Post procedural infection 35.17 21.93 18 6655 9579 64482480
Eye pruritus 33.15 21.93 19 6654 12640 64479419
Eye infection bacterial 32.94 21.93 7 6666 219 64491840
Anterior chamber inflammation 32.37 21.93 8 6665 493 64491566
Vitreous opacities 32.24 21.93 8 6665 501 64491558
Vitreous haemorrhage 31.85 21.93 12 6661 3073 64488986
Conjunctivitis 31.76 21.93 22 6651 20332 64471727
Cataract operation complication 31.52 21.93 7 6666 270 64491789
Lacrimation increased 31.40 21.93 21 6652 18325 64473734
Cystoid macular oedema 30.17 21.93 10 6663 1764 64490295
Retinal disorder 30.05 21.93 10 6663 1786 64490273
Anterior chamber disorder 29.97 21.93 6 6667 139 64491920
Ocular hypertension 29.24 21.93 9 6664 1252 64490807
Pseudoendophthalmitis 29.09 21.93 5 6668 48 64492011
Retinal scar 29.03 21.93 7 6666 389 64491670
Retinal oedema 28.58 21.93 8 6665 800 64491259
Iridocyclitis 28.41 21.93 11 6662 3034 64489025
Genital haemorrhage 28.21 21.93 13 6660 5509 64486550
Poor quality product administered 27.83 21.93 11 6662 3204 64488855
Ophthalmological examination abnormal 27.70 21.93 5 6668 65 64491994
Corneal opacity 27.68 21.93 8 6665 897 64491162
Haemorrhoids thrombosed 27.61 21.93 6 6667 209 64491850
Exophthalmos 27.36 21.93 9 6664 1551 64490508
Maculopathy 26.83 21.93 10 6663 2486 64489573
Anaphylactic shock 25.98 21.93 23 6650 30305 64461754
Keratic precipitates 25.54 21.93 6 6667 298 64491761
Photophobia 25.36 21.93 18 6655 17275 64474784
Delayed delivery 25.07 21.93 4 6669 23 64492036
Balanitis candida 24.80 21.93 5 6668 120 64491939
Photopsia 23.77 21.93 11 6662 4703 64487356
Retinal detachment 23.68 21.93 13 6660 7963 64484096
Dermatitis bullous 23.57 21.93 15 6658 12039 64480020
Enterocutaneous fistula 23.41 21.93 8 6665 1549 64490510
Fatigue 22.20 21.93 27 6646 748703 63743356
Device expulsion 22.15 21.93 18 6655 21118 64470941
Cardiac pacemaker removal 21.99 21.93 3 6670 4 64492055

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AG02 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Iodine products
ATC D09AA09 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC D11AC06 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Medicated shampoos
ATC G01AX11 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Other antiinfectives and antiseptics
ATC R02AA15 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
ATC S01AX18 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Other antiinfectives
FDA CS M0011640 Iodine
FDA EPC N0000175486 Antiseptic
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bacterial septicemia contraindication 10001005 DOID:0040085
Shock contraindication 27942005
Decreased respiratory function contraindication 80954004
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019273 VUID
N0000147472 NUI
D00863 KEGG_DRUG
4018171 VANDF
4019273 VANDF
C0032857 UMLSCUI
CHEBI:8347 CHEBI
CHEMBL1201724 ChEMBL_ID
D011206 MESH_DESCRIPTOR_UI
DB06812 DRUGBANK_ID
85H0HZU99M UNII
410087 PUBCHEM_CID
8611 RXNORM
1871 MMSL
5338 MMSL
003153 NDDF
111144003 SNOMEDCT_US
386989006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Betadine HUMAN PRESCRIPTION DRUG LABEL 1 0065-0411 SOLUTION 5 mg OPHTHALMIC NDA 16 sections
SUMMERS EVE HUMAN OTC DRUG LABEL 1 0132-8743 DOUCHE 4 g VAGINAL OTC MONOGRAPH NOT FINAL 12 sections
First Aid Antiseptic HUMAN OTC DRUG LABEL 1 0363-0777 SOLUTION 10 mg TOPICAL OTC monograph not final 13 sections
Apothecary PVP Topical HUMAN OTC DRUG LABEL 1 0363-0939 SOLUTION 1 g TOPICAL OTC monograph not final 11 sections
Humco Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-2325 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
Humco Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-2325 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9123 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9123 LIQUID 100 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9128 LIQUID 5 mg TOPICAL OTC monograph not final 14 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9128 LIQUID 5 mg TOPICAL OTC monograph not final 14 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9129 LIQUID 50 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9129 LIQUID 50 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9136 LIQUID 5 mg TOPICAL OTC monograph not final 14 sections
Povidone Iodine HUMAN OTC DRUG LABEL 1 0395-9136 LIQUID 5 mg TOPICAL OTC monograph not final 14 sections
Henry Schein Povidone-Iodine Swabsticks HUMAN OTC DRUG LABEL 1 0404-0119 SWAB 1 g TOPICAL OTC monograph not final 13 sections
Henry Schein Povidone-Iodine Prep Pad HUMAN OTC DRUG LABEL 1 0404-0121 SWAB 1 g TOPICAL OTC monograph not final 10 sections
povidine iodine HUMAN OTC DRUG LABEL 1 0404-5637 SWAB 10 mL TOPICAL OTC monograph final 11 sections
povidine iodine HUMAN OTC DRUG LABEL 1 0404-5638 SWAB 10 mL TOPICAL OTC monograph final 11 sections
povidine iodine HUMAN OTC DRUG LABEL 1 0404-5639 SWAB 10 mL TOPICAL OTC monograph final 11 sections
North PVP Iodine Swabs HUMAN OTC DRUG LABEL 1 0498-0118 SOLUTION 0.01 g TOPICAL unapproved drug other 14 sections
North PVP Iodine Wipe HUMAN OTC DRUG LABEL 1 0498-0120 SWAB 10 mg TOPICAL unapproved drug other 12 sections
PVP Iodine Wipe HUMAN OTC DRUG LABEL 1 0498-0121 SWAB 10 mg TOPICAL unapproved drug other 12 sections
PVP Iodine Swabs HUMAN OTC DRUG LABEL 1 0498-0128 SOLUTION 0.01 g TOPICAL unapproved drug other 14 sections
First Aid Antiseptic HUMAN OTC DRUG LABEL 1 0536-1271 OINTMENT 100 mg TOPICAL OTC monograph not final 13 sections
Povidone Iodine Solution First Aid Antiseptic HUMAN OTC DRUG LABEL 1 0869-0050 SOLUTION 10.34 mg TOPICAL OTC monograph not final 14 sections
Povidone Iodine Solution First Aid Antiseptic HUMAN OTC DRUG LABEL 1 0869-0050 SOLUTION 10.34 mg TOPICAL OTC monograph not final 14 sections
Major Povidone Iodine HUMAN OTC DRUG LABEL 1 0904-1102 OINTMENT 100 mg TOPICAL OTC monograph final 14 sections
povidone iodine HUMAN OTC DRUG LABEL 1 0904-1103 SOLUTION 100 mg TOPICAL OTC monograph final 11 sections
First Aid Only Povidone-Iodine Prep Pad HUMAN OTC DRUG LABEL 1 0924-8110 PATCH 10 g TOPICAL OTC monograph not final 9 sections
First Aid Only Povidone-Iodine Antiseptic HUMAN OTC DRUG LABEL 1 0924-8112 SWAB 1 g TOPICAL OTC monograph not final 12 sections