propamidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3493	104-32-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

propamidine
panamidin
propamidine dihydrochloride
propamidine hydrochloride
propamidine HCl
propamidine isetionate
propamidine isethionate

Molecular weight: 312.37
Formula: C17H20N4O2
CLOGP: 1.49
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 118.20
ALOGS: -3.73
ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AC03	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Biguanides and amidines
ATC	S01AX15	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Other antiinfectives
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000977	Antiparasitic Agents
MeSH PA	D000981	Antiprotozoal Agents
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:48218	antiseptics

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.38	Basic
pKa2	10.78	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Trypsin-1	Enzyme	P07477	TRY1_HUMAN		Ki	5.48		CHEMBL
Acrosin	Enzyme		ACRO_PIG		Ki	5.46		CHEMBL

External reference:

ID	Source
D07205	KEGG_DRUG
C0072159	UMLSCUI
CHEBI:87462	CHEBI
CHEMBL23013	ChEMBL_ID
DB13296	DRUGBANK_ID
C005555	MESH_SUPPLEMENTAL_RECORD_UI
64949	PUBCHEM_CID
C046651	MESH_SUPPLEMENTAL_RECORD_UI
4182	INN_ID
140-63-6	SECONDARY_CAS_RN
G20G12V769	UNII
34633	RXNORM
005501	NDDF
005502	NDDF
395847007	SNOMEDCT_US
395996003	SNOMEDCT_US
421796008	SNOMEDCT_US
TNT	PDB_CHEM_ID

Pharmaceutical products:

None