propamidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3493 104-32-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • propamidine
  • panamidin
  • propamidine dihydrochloride
  • propamidine hydrochloride
  • propamidine HCl
  • propamidine isetionate
  • propamidine isethionate
  • Molecular weight: 312.37
  • Formula: C17H20N4O2
  • CLOGP: 1.49
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 118.20
  • ALOGS: -3.73
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.441 High 0.88
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.274 High 0.88
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.207 10^-6 cm/s High 0.88
dh-clint Dog hepatocyte intrinsic clearance 5.200 uL/min/10^6 cells High 0.88
dppb Dog plasma protein binding (% unbound) 28.710 % High 0.88
fcs-ppb Fetal calf serum protein binding (% unbound) 48.390 % High 0.88
herg hERG pIC50 4.396 pIC50 High 0.88
hh-clint Human hepatocyte intrinsic clearance 1.854 uL/min/10^6 cells High 0.88
hlm-clint Human liver microsomal intrinsic clearance 5.768 uL/min/mg protein High 0.88
hppb Human plasma protein binding (% unbound) 60.820 % High 0.88
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KIT,MAP2K1,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 73
kinase-selectivity-class ACVR2B,BRAF,CDK4,EIF2AK3,ERBB2,GRK2,PDK4,SIK2,STK33 9
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.455 High 0.88
mh-clint Mouse hepatocyte intrinsic clearance 17.061 High 0.88
mppb Mouse plasma protein binding (% unbound) 26.190 High 0.88
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.849 High 0.88
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 0.88
pppb Pig plasma protein binding (% unbound) 76.560 % High 0.88
rh-clint Rat hepatocyte intrinsic clearance 2.812 uL/min/10^6 cells High 0.88
rh-fuinc Rat hepatocyte fraction unbound in incubation 35.360 % High 0.88
rppb Rat plasma protein binding (% unbound) 63.900 % High 0.88
solubility-dd Solubility at pH 7.4 in DMSO 298.538 uM High 0.88

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AC03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Biguanides and amidines
ATC S01AX15 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Other antiinfectives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:48218 antiseptic drug
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

D08AC Biguanides and amidines 4 drugs
chlorhexidinedibrompropamidinehexamidinepolihexanide
S01AX Other antiinfectives 13 drugs
bibrocatholcethexoniumchlorhexidinedibrompropamidinehexamidinelotilanernitrofurazonepicloxydinepolihexanidepovidone-iodineresorcinolsodium borate show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.38 Basic
pKa2 10.78 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Trypsin-1 Enzyme Ki 5.48 CHEMBL
Transmembrane protease serine 2 Enzyme IC50 5.05 CHEMBL
Acrosin Enzyme Ki 5.46 CHEMBL

External reference:

IDSource
D07205 KEGG_DRUG
C0072159 UMLSCUI
CHEBI:87462 CHEBI
CHEMBL23013 ChEMBL_ID
DB13296 DRUGBANK_ID
C005555 MESH_SUPPLEMENTAL_RECORD_UI
64949 PUBCHEM_CID
4182 INN_ID
G20G12V769 UNII
34633 RXNORM
005501 NDDF
005502 NDDF
395847007 SNOMEDCT_US
395996003 SNOMEDCT_US
421796008 SNOMEDCT_US
TNT PDB_CHEM_ID
140-63-6 SECONDARY_CAS_RN
C046651 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None