All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

hyaluronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	3957	9004-61-9

Description:

Molecule	Description
Synonyms: hyaluronate sodium hyaluronic acid hyaluronate	A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA. Molecular weight: Formula: (C14H21NO12)n CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
3.60	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	432.75	10.51	176	281251	287670	90059350
Acute kidney injury	413.21	10.51	241	281186	320146	90026874
Completed suicide	398.95	10.51	11	281416	145047	90201973
Rheumatoid arthritis	381.57	10.51	2170	279257	360444	89986576
Night sweats	378.95	10.51	1065	280362	127701	90219319
Psoriatic arthropathy	363.17	10.51	1538	279889	226797	90120223
Rheumatic fever	354.44	10.51	1164	280263	151957	90195063
Drug interaction	343.77	10.51	217	281210	276236	90070784
Bursitis	329.41	10.51	1028	280399	130626	90216394
Lip dry	326.97	10.51	865	280562	100090	90246930
Prescribed overdose	316.71	10.51	837	280590	96788	90250232
Fibromyalgia	309.25	10.51	1365	280062	204904	90142116
Peripheral venous disease	287.08	10.51	734	280693	83187	90263833
Temperature regulation disorder	279.21	10.51	282	281145	14297	90332723
Type 2 diabetes mellitus	274.95	10.51	1305	280122	201939	90145081
Liver injury	271.92	10.51	1150	280277	169417	90177603
Food allergy	263.21	10.51	359	281068	25119	90321901
Facet joint syndrome	255.11	10.51	778	280649	97611	90249409
Swollen joint count increased	253.34	10.51	841	280586	110365	90236655
Neutropenia	238.88	10.51	208	281219	224696	90122324
Joint range of motion decreased	235.47	10.51	939	280488	134704	90212316
C-reactive protein abnormal	228.35	10.51	891	280536	126538	90220482
Road traffic accident	227.65	10.51	794	280633	106832	90240188
Urticaria	221.14	10.51	1695	279732	311039	90035981
Deep vein thrombosis postoperative	220.44	10.51	598	280829	70211	90276809
Intentional overdose	217.93	10.51	20	281407	93814	90253206
Cardiac arrest	210.70	10.51	36	281391	104899	90242121
Lower limb fracture	209.97	10.51	661	280766	84352	90262668
Injury	209.82	10.51	1185	280242	196164	90150856
Folliculitis	209.37	10.51	1215	280212	203138	90143882
Immunodeficiency	207.29	10.51	432	280995	42802	90304218
Asthma	206.28	10.51	1373	280054	240787	90106233
Dry mouth	206.22	10.51	1121	280306	182938	90164082
Muscle injury	202.04	10.51	1082	280345	175572	90171448
Duodenal ulcer perforation	199.66	10.51	1273	280154	220015	90127005
Irritable bowel syndrome	198.16	10.51	1211	280216	206237	90140783
Blood cholesterol increased	197.88	10.51	1213	280214	206799	90140221
Gait inability	192.63	10.51	933	280494	145523	90201497
Autoimmune disorder	187.95	10.51	595	280832	76149	90270871
Helicobacter infection	184.11	10.51	1271	280156	225579	90121441
Macular degeneration	180.40	10.51	378	281049	37592	90309428
Impaired healing	177.72	10.51	1291	280136	232908	90114112
Mobility decreased	175.50	10.51	1356	280071	249378	90097642
Renal failure	172.36	10.51	96	281331	130911	90216109
Sleep disorder due to general medical condition, insomnia type	172.22	10.51	824	280603	127870	90219150
Sensitisation	171.25	10.51	125	281302	4050	90342970
Abdominal pain upper	166.37	10.51	1671	279756	331003	90016017
Sciatica	164.94	10.51	688	280739	100694	90246326
Drug ineffective	163.92	10.51	3175	278252	1381123	88965897
Coeliac disease	162.81	10.51	400	281027	44210	90302810
Suicide attempt	162.58	10.51	21	281406	75378	90271642
Pancytopenia	159.85	10.51	87	281340	120176	90226844
Death	159.50	10.51	802	280625	455749	89891271
Wheezing	158.59	10.51	1273	280154	236807	90110213
Obesity	157.80	10.51	698	280729	104809	90242211
Infusion related reaction	154.38	10.51	1974	279453	414806	89932214
Seizure	153.89	10.51	148	281279	152481	90194539
Taste disorder	153.30	10.51	480	280947	61066	90285954
Ill-defined disorder	152.99	10.51	1041	280386	183850	90163170
Stomatitis	152.19	10.51	1410	280017	273288	90073732
Pericarditis	145.82	10.51	1379	280048	268772	90078248
Ear pain	144.62	10.51	451	280976	57251	90289769
Febrile neutropenia	144.56	10.51	167	281260	158182	90188838
Ejection fraction	141.62	10.51	98	281329	2913	90344107
Sleep disorder	140.76	10.51	1075	280352	196955	90150065
Polycystic ovaries	139.90	10.51	126	281301	5528	90341492
Anaemia	137.78	10.51	595	280832	352207	89994813
Hypotension	137.58	10.51	532	280895	324865	90022155
Lung disorder	136.81	10.51	865	280562	149018	90198002
Septic shock	135.51	10.51	46	281381	84114	90262906
Lower respiratory tract infection	135.01	10.51	1279	280148	249380	90097640
Cardiac failure	134.54	10.51	87	281340	109409	90237611
Hepatic enzyme increased	134.13	10.51	1710	279717	359026	89987994
X-ray abnormal	132.82	10.51	375	281052	45049	90301971
Sinusitis	131.68	10.51	1636	279791	341452	90005568
Cardio-respiratory arrest	130.47	10.51	20	281407	63120	90283900
Liver disorder	128.02	10.51	727	280700	120542	90226478
Wound infection	127.96	10.51	661	280766	105741	90241279
C-reactive protein	127.16	10.51	293	281134	31074	90315946
Hypoaesthesia	126.51	10.51	1512	279915	312698	90034322
Musculoskeletal pain	126.41	10.51	938	280489	170313	90176707
Wound	124.20	10.51	1463	279964	301517	90045503
Rheumatoid factor positive	123.77	10.51	935	280492	170715	90176305
Blister	123.16	10.51	1272	280155	253726	90093294
Hypokalaemia	122.16	10.51	136	281291	130980	90216040
Live birth	120.28	10.51	526	280901	78581	90268439
Lupus vulgaris	120.22	10.51	360	281067	44699	90302321
Multiple organ dysfunction syndrome	119.72	10.51	32	281395	68304	90278716
Electrocardiogram QT prolonged	119.48	10.51	38	281389	72418	90274602
Respiratory failure	119.16	10.51	115	281312	118303	90228717
Drug abuse	117.81	10.51	54	281373	82293	90264727
Breast cancer stage III	117.54	10.51	547	280880	83900	90263120
Renal impairment	117.42	10.51	93	281334	105328	90241692
Hyperkalaemia	116.54	10.51	29	281398	64935	90282085
Disease progression	116.04	10.51	192	281235	156423	90190597
Respiratory disorder	115.06	10.51	452	280975	64364	90282656
Sepsis	113.38	10.51	243	281184	179571	90167449
Joint swelling	111.74	10.51	2188	279239	501112	89845908
Hyponatraemia	108.25	10.51	154	281273	133384	90213636
Loss of consciousness	107.59	10.51	168	281259	140070	90206950
Bradycardia	106.63	10.51	64	281363	83783	90263237
Blepharospasm	105.26	10.51	395	281032	55050	90291970
Muscle spasticity	103.65	10.51	292	281135	35030	90311990
Pulmonary embolism	102.00	10.51	155	281272	130665	90216355
Rhabdomyolysis	101.97	10.51	18	281409	51238	90295782
Angioedema	101.80	10.51	37	281390	64839	90282181
Gastrooesophageal reflux disease	101.39	10.51	872	280555	165465	90181555
Peripheral swelling	100.28	10.51	1821	279606	411285	89935735
Metabolic acidosis	99.58	10.51	25	281402	55651	90291369
Ulcer haemorrhage	99.22	10.51	239	281188	26082	90320938
Myocardial infarction	98.62	10.51	110	281317	105862	90241158
Lactic acidosis	97.65	10.51	19	281408	50444	90296576
Inflammation	96.46	10.51	912	280515	177680	90169340
Weight increased	95.81	10.51	1826	279601	416101	89930919
Malignant neoplasm progression	95.07	10.51	115	281312	106755	90240265
Hypoglycaemia	95.06	10.51	49	281378	69799	90277221
Osteoarthritis	93.82	10.51	975	280452	194755	90152265
Syncope	92.48	10.51	169	281258	132494	90214526
Dehydration	91.36	10.51	304	281123	194143	90152877
Hand deformity	89.06	10.51	1353	280074	295009	90052011
Onychomadesis	86.74	10.51	327	281100	45671	90301349
Nasopharyngitis	86.32	10.51	1758	279669	405346	89941674
Interstitial lung disease	85.59	10.51	67	281360	76338	90270682
Glossodynia	85.41	10.51	1439	279988	320340	90026680
Chronic sinusitis	85.33	10.51	212	281215	23590	90323430
Mucosal inflammation	85.25	10.51	36	281391	57589	90289431
Intentional product use issue	85.17	10.51	1039	280388	215853	90131167
Drug reaction with eosinophilia and systemic symptoms	85.09	10.51	15	281412	42743	90304277
Alanine aminotransferase increased	84.96	10.51	148	281279	118190	90228830
Encephalopathy	84.74	10.51	20	281407	46424	90300596
Cholestasis	83.58	10.51	8	281419	36291	90310729
Fluid retention	82.60	10.51	512	280915	87579	90259441
Hypertension	81.82	10.51	1928	279499	455604	89891416
Hypercholesterolaemia	81.58	10.51	565	280862	100327	90246693
Foetal exposure during pregnancy	81.45	10.51	17	281410	42958	90304062
Pemphigus	80.02	10.51	1443	279984	325421	90021599
Insomnia	79.48	10.51	1466	279961	332008	90015012
Suicidal ideation	78.72	10.51	68	281359	73787	90273233
Intentional self-injury	77.86	10.51	3	281424	29331	90317689
Upper respiratory tract infection	77.81	10.51	672	280755	127646	90219374
Anti-cyclic citrullinated peptide antibody positive	77.54	10.51	1096	280331	235337	90111683
Rash erythematous	77.25	10.51	403	281024	64701	90282319
Dyspepsia	77.24	10.51	948	280479	197212	90149808
Hypoxia	76.75	10.51	67	281360	72332	90274688
Frequent bowel movements	76.44	10.51	365	281062	56570	90290450
Hepatic cytolysis	76.24	10.51	5	281422	30911	90316109
Gastrointestinal disorder	75.61	10.51	1168	280259	255519	90091501
Synovitis	75.25	10.51	1440	279987	328312	90018708
Muscle spasms	74.90	10.51	1148	280279	250735	90096285
Ejection fraction abnormal	72.71	10.51	61	281366	2430	90344590
Serotonin syndrome	71.77	10.51	15	281412	37872	90309148
Adverse event	71.24	10.51	615	280812	116803	90230217
Hepatocellular injury	70.49	10.51	5	281422	28953	90318067
Liver function test abnormal	70.19	10.51	35	281392	50810	90296210
Treatment failure	69.95	10.51	1329	280098	302599	90044421
Blood creatinine increased	69.91	10.51	130	281297	101256	90245764
Vaginal flatulence	69.82	10.51	134	281293	12504	90334516
Retinitis	69.72	10.51	270	281157	38188	90308832
Dislocation of vertebra	69.57	10.51	351	281076	55617	90291403
Grip strength decreased	69.36	10.51	509	280918	92067	90254953
Adjustment disorder with depressed mood	69.20	10.51	354	281073	56399	90290621
Cough	69.18	10.51	772	280655	368190	89978830
Product quality issue	68.78	10.51	452	280975	78873	90268147
Rhinitis allergic	68.26	10.51	157	281270	16628	90330392
Breast cancer stage II	68.13	10.51	253	281174	35081	90311939
Cardiac failure congestive	67.65	10.51	127	281300	98567	90248453
Sleep disorder due to a general medical condition	67.63	10.51	297	281130	44441	90302579
Contraindicated product administered	66.67	10.51	1379	280048	318760	90028260
Myelosuppression	66.62	10.51	42	281385	53549	90293471
Migraine	66.24	10.51	892	280535	189500	90157520
Memory impairment	66.13	10.51	918	280509	196326	90150694
Maternal exposure timing unspecified	66.10	10.51	186	281241	22297	90324723
Transaminases increased	65.94	10.51	17	281410	37175	90309845
Aspartate aminotransferase increased	65.79	10.51	138	281289	102799	90244221
Foetal death	65.45	10.51	176	281251	20547	90326473
Anaphylactic reaction	65.09	10.51	107	281320	87417	90259603
Therapy non-responder	65.02	10.51	680	280747	136024	90210996
Body temperature increased	64.71	10.51	293	281134	44417	90302603
Ventricular tachycardia	64.01	10.51	3	281424	24705	90322315
Eosinophilia	63.85	10.51	7	281420	28526	90318494
Atrial fibrillation	62.66	10.51	209	281218	133402	90213618
Disorientation	61.45	10.51	30	281397	44084	90302936
Nephrectomy	60.92	10.51	50	281377	1931	90345089
Carpal tunnel syndrome	60.84	10.51	188	281239	23740	90323280
Tachycardia	60.20	10.51	268	281159	157405	90189615
Agranulocytosis	60.17	10.51	17	281410	34985	90312035
Somnolence	59.59	10.51	392	281035	208692	90138328
Oedema	58.80	10.51	911	280516	199384	90147636
Bone marrow failure	58.54	10.51	14	281413	32207	90314813
Pleural effusion	58.32	10.51	167	281260	111824	90235196
Device expulsion	58.18	10.51	27	281400	40859	90306161
Nausea	57.70	10.51	2840	278587	1107476	89239544
Blood test abnormal	57.40	10.51	169	281258	20783	90326237
Laryngitis	57.36	10.51	310	281117	50443	90296577
Abortion spontaneous	57.33	10.51	50	281377	54006	90293014
Hepatic failure	56.90	10.51	26	281401	39702	90307318
Rash maculo-papular	56.77	10.51	28	281399	40905	90306115
Cerebrovascular accident	56.73	10.51	195	281232	123338	90223682
Premature baby	56.50	10.51	6	281421	25071	90321949
Systemic lupus erythematosus	56.31	10.51	1497	279930	360399	89986621
Anti-cyclic citrullinated peptide antibody	55.94	10.51	199	281228	27022	90319998
Contusion	55.90	10.51	1093	280334	250123	90096897
Hypersensitivity	55.32	10.51	1824	279603	452853	89894167
Deep vein thrombosis	55.12	10.51	127	281300	91493	90255527
Proctitis	54.79	10.51	136	281291	15123	90331897
Cardiogenic shock	54.76	10.51	6	281421	24462	90322558
Hallucination	54.50	10.51	75	281352	65884	90281136
Pneumonia	54.39	10.51	1537	279890	636522	89710498
Hypocalcaemia	54.34	10.51	32	281395	42336	90304684
Psychotic disorder	53.99	10.51	15	281412	31215	90315805
International normalised ratio increased	53.62	10.51	41	281386	47275	90299745
Sedation complication	53.61	10.51	144	281283	16800	90330220
Pulmonary fibrosis	53.13	10.51	539	280888	106964	90240056
Premature delivery	53.03	10.51	27	281400	38735	90308285
Unresponsive to stimuli	52.98	10.51	26	281401	38095	90308925
Tremor	52.83	10.51	270	281157	152903	90194117
Exostosis	52.44	10.51	313	281114	52821	90294199
Tubulointerstitial nephritis	52.42	10.51	8	281419	25335	90321685
Product use issue	52.26	10.51	1368	280059	328551	90018469
Nail disorder	52.07	10.51	338	281089	58729	90288291
Paraesthesia	51.67	10.51	1077	280350	249249	90097771
Hepatotoxicity	51.59	10.51	40	281387	45802	90301218
Deafness transitory	51.48	10.51	46	281381	1997	90345023
Headache	51.42	10.51	3218	278209	859528	89487492
Cytokine release syndrome	51.12	10.51	12	281415	27961	90319059
Leukopenia	51.12	10.51	152	281275	100558	90246462
Ischaemic stroke	50.73	10.51	5	281422	22161	90324859
Diabetes mellitus	49.47	10.51	78	281349	64797	90282223
Cytomegalovirus infection	49.44	10.51	11	281416	26591	90320429
Urinary retention	49.13	10.51	28	281399	37716	90309304
Drug dependence	49.03	10.51	15	281412	29312	90317708
Hypomagnesaemia	48.37	10.51	25	281402	35563	90311457
Generalised tonic-clonic seizure	48.21	10.51	24	281403	34879	90312141
Agitation	48.08	10.51	84	281343	67014	90280006
No adverse event	47.90	10.51	86	281341	67896	90279124
Hepatic function abnormal	47.67	10.51	44	281383	46244	90300776
Hyperglycaemia	47.31	10.51	53	281374	50917	90296103
Colitis ulcerative	47.24	10.51	335	281092	59931	90287089
Pulmonary oedema	47.00	10.51	75	281352	62005	90285015
Creatinine renal clearance decreased	46.68	10.51	147	281280	18752	90328268
Oxygen saturation decreased	46.47	10.51	174	281253	107309	90239711
Female genital tract fistula	46.00	10.51	141	281286	17727	90329293
Respiratory arrest	45.87	10.51	23	281404	33288	90313732
Toxic anterior segment syndrome	45.81	10.51	45	281382	2205	90344815
Subcutaneous drug absorption impaired	45.80	10.51	118	281309	13427	90333593
Hepatic cirrhosis	45.80	10.51	345	281082	62908	90284112
Back injury	45.60	10.51	274	281153	46348	90300672
Dyspnoea	45.35	10.51	2255	279172	878700	89468320
Arthropathy	45.23	10.51	1472	279955	364770	89982250
Respiratory distress	45.09	10.51	33	281394	38913	90308107
Musculoskeletal stiffness	45.07	10.51	1223	280204	295309	90051711
Paraesthesia oral	44.72	10.51	206	281221	31453	90315567
Swollen tongue	44.64	10.51	46	281381	45910	90301110
Altered state of consciousness	44.60	10.51	21	281406	31511	90315509
Therapeutic product effect incomplete	44.27	10.51	847	280580	193049	90153971
Mental status changes	44.23	10.51	44	281383	44635	90302385
Bone erosion	44.08	10.51	299	281128	52722	90294298
Palpitations	43.83	10.51	247	281180	136481	90210539
Melaena	43.62	10.51	27	281400	34770	90312250
Swelling	43.49	10.51	1651	279776	417407	89929613
Inappropriate antidiuretic hormone secretion	43.10	10.51	5	281422	19500	90327520
Circulatory collapse	42.98	10.51	12	281415	24892	90322128
Metastases to liver	42.60	10.51	18	281409	28789	90318231
Prescribed underdose	42.43	10.51	387	281040	74632	90272388
Vaginal discharge	42.34	10.51	145	281282	19319	90327701
Drug eruption	42.31	10.51	29	281398	35378	90311642
Dysphagia	42.15	10.51	192	281235	112086	90234934
Radiculopathy	42.15	10.51	140	281287	18365	90328655
Pneumocystis jirovecii pneumonia	42.11	10.51	8	281419	21608	90325412
Cholelithiasis	42.09	10.51	61	281366	52445	90294575
Dysarthria	42.02	10.51	65	281362	54417	90292603
Posterior reversible encephalopathy syndrome	42.00	10.51	9	281418	22330	90324690
Anaphylactic shock	41.81	10.51	23	281404	31594	90315426
Epilepsy	41.02	10.51	413	281014	81793	90265227
Blood pressure decreased	40.99	10.51	109	281318	74786	90272234
Shock	40.96	10.51	19	281408	28759	90318261
Lupus-like syndrome	40.93	10.51	276	281151	48570	90298450
Coronary artery disease	40.90	10.51	27	281400	33596	90313424
Acute respiratory distress syndrome	40.73	10.51	19	281408	28667	90318353
Sinus tachycardia	40.31	10.51	19	281408	28494	90318526
Drug level increased	40.02	10.51	18	281409	27744	90319276
Dyskinesia	39.71	10.51	33	281394	36501	90310519
Myalgia	39.64	10.51	350	281077	174775	90172245
Blood bilirubin increased	39.48	10.51	46	281381	43424	90303596
Stevens-Johnson syndrome	39.39	10.51	21	281406	29355	90317665
Gastrointestinal haemorrhage	39.08	10.51	146	281281	90102	90256918
Lupus vasculitis	38.91	10.51	24	281403	584	90346436
Acute hepatic failure	38.70	10.51	11	281416	22550	90324470
Urinary tract infection	38.59	10.51	692	280735	304940	90042080
Eye injury	38.29	10.51	97	281330	10923	90336097
Rheumatoid nodule	38.17	10.51	8	281419	20158	90326862
Fall	37.91	10.51	1173	280254	480637	89866383
Ascites	37.74	10.51	56	281371	47684	90299336
Metastases to bone	37.62	10.51	16	281411	25489	90321531
Toxic skin eruption	37.61	10.51	3	281424	15771	90331249
Myoclonus	37.54	10.51	7	281420	19161	90327859
Constipation	37.23	10.51	1137	280290	279258	90067762
Arrhythmia	37.17	10.51	46	281381	42286	90304734
Poisoning deliberate	37	10.51	4	281423	16482	90330538
Haematoma	36.91	10.51	40	281387	39008	90308012
Discomfort	36.85	10.51	1114	280313	273221	90073799
Poisoning	35.99	10.51	3	281424	15214	90331806
Polyneuropathy	35.94	10.51	8	281419	19333	90327687
Aggression	35.85	10.51	19	281408	26649	90320371
Onychomycosis	35.50	10.51	218	281209	37158	90309862
Haematuria	35.05	10.51	34	281393	34903	90312117
Drug resistance	34.99	10.51	26	281401	30423	90316597
Status epilepticus	34.68	10.51	8	281419	18866	90328154
Drug ineffective for unapproved indication	34.24	10.51	100	281327	66544	90280476
Pneumonitis	33.78	10.51	53	281374	44117	90302903
Hypercalcaemia	33.57	10.51	34	281393	34206	90312814
Pain	33.43	10.51	3557	277870	992784	89354236
Jaundice	33.38	10.51	31	281396	32486	90314534
Blood creatine phosphokinase increased	33.11	10.51	34	281393	33989	90313031
Lymphadenopathy	33.07	10.51	57	281370	45718	90301302
Body tinea	33.06	10.51	37	281390	2111	90344909
Pregnancy	33.04	10.51	316	281111	61731	90285289
Infection	32.78	10.51	1406	280021	360688	89986332
Osteonecrosis of jaw	32.77	10.51	44	281383	39059	90307961
General symptom	32.54	10.51	110	281317	14558	90332462
Therapy partial responder	32.24	10.51	14	281413	22029	90324991
Toxic epidermal necrolysis	32.23	10.51	32	281395	32496	90314524
Osteonecrosis	32.02	10.51	21	281406	26220	90320800
Sleep apnoea syndrome	31.96	10.51	188	281239	31559	90315461
Blood pressure systolic increased	31.86	10.51	85	281342	58260	90288760
Drug hypersensitivity	31.85	10.51	1752	279675	461857	89885163
Hallucination, visual	31.71	10.51	16	281411	23076	90323944
Pulmonary hypertension	31.60	10.51	52	281375	42471	90304549
Hypocholesterolaemia	31.56	10.51	65	281362	6384	90340636
Tenosynovitis	31.54	10.51	4	281423	14563	90332457
Skin necrosis	31.49	10.51	7	281420	16934	90330086
Panniculitis	31.23	10.51	4	281423	14454	90332566
Pallor	31.19	10.51	36	281391	34129	90312891
Dystonia	31.16	10.51	7	281420	16812	90330208
Disseminated intravascular coagulation	30.99	10.51	14	281413	21524	90325496
Neurotoxicity	30.82	10.51	14	281413	21453	90325567
Muscle rigidity	30.81	10.51	4	281423	14305	90332715
Porphyria acute	30.80	10.51	124	281303	17851	90329169
Neutropenic sepsis	30.80	10.51	9	281418	18121	90328899
Neuroleptic malignant syndrome	30.69	10.51	5	281422	15091	90331929
Diabetic ketoacidosis	30.51	10.51	19	281408	24388	90322632
Caesarean section	30.17	10.51	10	281417	18567	90328453
Ventricular fibrillation	30.06	10.51	4	281423	14040	90332980
Rash vesicular	29.97	10.51	124	281303	18073	90328947
Bronchiectasis	29.88	10.51	16	281411	22314	90324706
Chronic kidney disease	29.84	10.51	70	281357	50121	90296899
Vaginal haemorrhage	29.59	10.51	32	281395	31239	90315781
Sinus bradycardia	29.57	10.51	8	281419	16944	90330076
Gamma-glutamyltransferase increased	29.54	10.51	45	281382	37907	90309113
Dyspnoea exertional	29.34	10.51	120	281307	72168	90274852
Labelled drug-drug interaction medication error	29.27	10.51	5	281422	14577	90332443
Creatinine renal clearance increased	29.11	10.51	43	281384	3238	90343782
Tachypnoea	28.91	10.51	15	281412	21294	90325726
Acute myeloid leukaemia	28.80	10.51	14	281413	20626	90326394
Ataxia	28.80	10.51	10	281417	18032	90328988
Blood calcium decreased	28.64	10.51	176	281251	30006	90317014
Psoriasis	28.62	10.51	630	280797	147124	90199896
Acute myocardial infarction	28.50	10.51	40	281387	34850	90312170
Pericardial effusion	28.35	10.51	44	281383	36789	90310231
Thrombotic microangiopathy	28.28	10.51	7	281420	15736	90331284
Haematotoxicity	28.24	10.51	3	281424	12532	90334488
Extrapyramidal disorder	27.87	10.51	8	281419	16295	90330725
Incorrect dose administered	27.85	10.51	138	281289	78792	90268228
Anuria	27.79	10.51	6	281421	14812	90332208
Cardiomyopathy	27.75	10.51	14	281413	20192	90326828
Infusion site reaction	27.72	10.51	125	281302	18914	90328106
Chest discomfort	27.70	10.51	285	281142	138080	90208940
Procedural pain	27.65	10.51	188	281239	33172	90313848
Drug withdrawal syndrome	27.62	10.51	29	281398	28694	90318326
Tendonitis	27.61	10.51	16	281411	21356	90325664
Basal cell carcinoma	27.55	10.51	38	281389	33351	90313669
Haematemesis	27.21	10.51	39	281388	33687	90313333
Incorrect route of product administration	27.04	10.51	258	281169	50368	90296652
Mouth ulceration	26.90	10.51	52	281375	39922	90307098
Staphylococcal infection	26.88	10.51	70	281357	48369	90298651
Acute generalised exanthematous pustulosis	26.85	10.51	5	281422	13698	90333322
Right ventricular failure	26.84	10.51	13	281414	19192	90327828
Swollen joint count	26.83	10.51	73	281354	8580	90338440
Ear infection	26.81	10.51	333	281094	69442	90277578
Decreased appetite	26.64	10.51	1427	280000	375113	89971907
Peritonitis	26.55	10.51	14	281413	19691	90327329
Overlap syndrome	26.39	10.51	72	281355	8476	90338544
Keratopathy	26.36	10.51	20	281407	688	90346332
Angina pectoris	26.30	10.51	51	281376	39109	90307911
Infection susceptibility increased	25.96	10.51	45	281382	3881	90343139
Premature labour	25.95	10.51	5	281422	13371	90333649
Product use in unapproved indication	25.76	10.51	1284	280143	334952	90012068
Aplastic anaemia	25.66	10.51	5	281422	13264	90333756
Accidental overdose	25.59	10.51	30	281397	28243	90318777
Diabetes mellitus inadequate control	25.58	10.51	13	281414	18671	90328349
Nervous system disorder	25.39	10.51	18	281409	21575	90325445
Thrombocytopenia	25.26	10.51	476	280951	208249	90138771
Abnormal behaviour	25.14	10.51	20	281407	22608	90324412
Blood lactate dehydrogenase increased	25.14	10.51	26	281401	25906	90321114
Myelodysplastic syndrome	25.14	10.51	17	281410	20886	90326134
Multiple fractures	25.12	10.51	76	281351	9486	90337534
Skin ulcer	25.10	10.51	76	281351	49999	90297021
Device dislocation	24.82	10.51	37	281390	31445	90315575
Disturbance in attention	24.70	10.51	70	281357	47039	90299981
Gastroenteritis	24.38	10.51	33	281394	29196	90317824
Akathisia	24.31	10.51	3	281424	11156	90335864
Cerebral infarction	24.31	10.51	28	281399	26568	90320452
Influenza	24.27	10.51	296	281131	138968	90208052
Cardiovascular disorder	24.24	10.51	6	281421	13486	90333534
Pustular psoriasis	24.21	10.51	118	281309	18438	90328582
General physical health deterioration	24.17	10.51	1341	280086	353774	89993246
Vasculitis	24.05	10.51	21	281406	22672	90324348
Hepatic steatosis	24.05	10.51	49	281378	36896	90310124
Blood glucose increased	23.98	10.51	185	281242	95061	90251959
Product substitution issue	23.96	10.51	13	281414	17995	90329025
Subarachnoid haemorrhage	23.71	10.51	13	281414	17891	90329129
Tuberculosis	23.70	10.51	5	281422	12544	90334476
Hallucination, auditory	23.59	10.51	10	281417	15965	90331055
Exposure during pregnancy	23.44	10.51	934	280493	237476	90109544
Coma	23.39	10.51	131	281296	72501	90274519
Cardiomegaly	23.29	10.51	15	281412	18910	90328110
Myocardial ischaemia	23.21	10.51	7	281420	13807	90333213
Cyanosis	23.16	10.51	16	281411	19439	90327581
Complication associated with device	23.15	10.51	16	281411	19433	90327587
Abdominal discomfort	23.14	10.51	1751	279676	475577	89871443
Face oedema	23.04	10.51	23	281404	23295	90323725
Cardiac murmur	22.97	10.51	14	281413	18180	90328840
Granuloma skin	22.96	10.51	3	281424	10677	90336343
Gastric ulcer	22.89	10.51	31	281396	27417	90319603
Device difficult to use	22.81	10.51	13	281414	17512	90329508
Adrenal insufficiency	22.79	10.51	36	281391	29885	90317135
Device malfunction	22.73	10.51	19	281408	20958	90326062
Mental disorder	22.66	10.51	41	281386	32277	90314743
Renal function test abnormal	22.63	10.51	61	281366	7130	90339890
Schizophrenia	22.57	10.51	9	281418	14905	90332115
Hip arthroplasty	22.49	10.51	347	281080	75861	90271159
Functional gastrointestinal disorder	22.43	10.51	49	281378	5013	90342007
Vertigo	22.43	10.51	126	281301	69685	90277335
Haemorrhage	22.40	10.51	125	281302	69244	90277776
Cerebral haemorrhage	22.29	10.51	46	281381	34476	90312544
Pyelonephritis	22.26	10.51	20	281407	21296	90325724
Gastrointestinal pain	22.24	10.51	81	281346	11125	90335895
Metastases to lung	22.08	10.51	11	281416	15980	90331040
Hypertensive crisis	22.02	10.51	14	281413	17770	90329250
Epstein-Barr virus infection	22.01	10.51	3	281424	10341	90336679
Heart rate increased	22.01	10.51	234	281193	112668	90234352
Proteinuria	21.85	10.51	24	281403	23267	90323753
Drug-induced liver injury	21.79	10.51	398	281029	89920	90257100
Renal tubular necrosis	21.68	10.51	9	281418	14546	90332474
Haemorrhage intracranial	21.59	10.51	10	281417	15152	90331868
Mydriasis	21.23	10.51	10	281417	15002	90332018
Jaundice cholestatic	21.16	10.51	3	281424	10040	90336980
Dermatitis atopic	21.10	10.51	135	281292	23337	90323683
Nail bed inflammation	21.10	10.51	27	281400	1774	90345246
Aspergillus infection	21.10	10.51	4	281423	10819	90336201
Palmar-plantar erythrodysaesthesia syndrome	21.07	10.51	34	281393	27989	90319031
Disability	20.95	10.51	206	281221	40539	90306481
Product administration error	20.88	10.51	31	281396	26392	90320628
Underdose	20.84	10.51	258	281169	53759	90293261
Coagulopathy	20.77	10.51	25	281402	23264	90323756
Bronchopulmonary aspergillosis	20.61	10.51	5	281422	11393	90335627
Product prescribing error	20.47	10.51	39	281388	30106	90316914
Escherichia infection	20.39	10.51	12	281415	15883	90331137
Stress cardiomyopathy	20.31	10.51	8	281419	13347	90333673
Neuropathy peripheral	20.29	10.51	301	281126	136669	90210351
Leukocytosis	20.26	10.51	41	281386	30949	90316071
Ulcer	20.24	10.51	45	281382	32837	90314183
Haemoptysis	20.19	10.51	46	281381	33274	90313746
Stoma site dermatitis	20.13	10.51	12	281415	274	90346746
Hemiparesis	20.04	10.51	43	281384	31776	90315244
Flushing	19.95	10.51	177	281250	88314	90258706
Intentional product misuse	19.95	10.51	390	281037	89214	90257806
Chills	19.91	10.51	289	281138	131692	90215328
Progressive multifocal leukoencephalopathy	19.83	10.51	12	281415	15643	90331377
Adverse reaction	19.81	10.51	159	281268	29553	90317467
Ankylosing spondylitis	19.75	10.51	8	281419	13125	90333895
Treatment noncompliance	19.68	10.51	88	281339	51639	90295381
Oral candidiasis	19.59	10.51	182	281245	35273	90311747
Transient ischaemic attack	19.25	10.51	69	281358	43107	90303913
Myopathy	19.12	10.51	9	281418	13509	90333511
Pulmonary toxicity	19.09	10.51	6	281421	11525	90335495
Mania	19.08	10.51	10	281417	14114	90332906
Lung infiltration	18.96	10.51	12	281415	15270	90331750
Nasal mucosal disorder	18.92	10.51	26	281401	1831	90345189
Acute respiratory failure	18.86	10.51	69	281358	42849	90304171
Blood pressure increased	18.86	10.51	467	280960	196750	90150270
C-reactive protein increased	18.86	10.51	715	280712	180674	90166346
Adverse drug reaction	18.76	10.51	485	280942	116216	90230804
Accidental exposure to product	18.69	10.51	68	281359	42298	90304722
Swelling face	18.66	10.51	162	281265	81190	90265830
Nephropathy toxic	18.65	10.51	8	281419	12680	90334340
Pain in jaw	18.64	10.51	81	281346	47904	90299116
Epistaxis	18.44	10.51	172	281255	84953	90262067
Presyncope	18.40	10.51	45	281382	31760	90315260
Obstructive defaecation	18.15	10.51	11	281416	259	90346761
Pancreatitis acute	18.14	10.51	46	281381	32069	90314951
Subdural haematoma	18.13	10.51	15	281412	16630	90330390
Faecaloma	18.05	10.51	5	281422	10426	90336594
Inhibitory drug interaction	18.04	10.51	34	281393	3129	90343891
Decreased immune responsiveness	18.01	10.51	64	281363	8684	90338336
Atelectasis	18.00	10.51	30	281397	24379	90322641
Obstructive airways disorder	17.98	10.51	33	281394	25836	90321184
Hydronephrosis	17.94	10.51	8	281419	12394	90334626
Crepitations	17.84	10.51	3	281424	8849	90338171
Haemolytic anaemia	17.80	10.51	7	281420	11690	90335330
Gastritis	17.78	10.51	68	281359	41685	90305335
Acute pulmonary oedema	17.72	10.51	4	281423	9576	90337444
Lethargy	17.66	10.51	119	281308	63020	90284000
Renal injury	17.56	10.51	5	281422	10238	90336782
Shock haemorrhagic	17.56	10.51	8	281419	12237	90334783
Genital haemorrhage	17.43	10.51	3	281424	8699	90338321
Psychomotor hyperactivity	17.41	10.51	9	281418	12804	90334216
Breast cancer	17.29	10.51	97	281330	53664	90293356
Acute coronary syndrome	17.25	10.51	6	281421	10807	90336213
Osteomyelitis	17.23	10.51	38	281389	27808	90319212
Sputum discoloured	17.03	10.51	23	281404	20368	90326652
Haemoglobin decreased	17.02	10.51	378	281049	161578	90185442
Hypervolaemia	16.94	10.51	49	281378	32708	90314312
Atrioventricular block first degree	16.90	10.51	3	281424	8508	90338512
Pulmonary arterial hypertension	16.82	10.51	35	281392	26152	90320868
Antinuclear antibody positive	16.82	10.51	4	281423	9237	90337783
Blood immunoglobulin M increased	16.76	10.51	21	281406	1351	90345669
Joint effusion	16.70	10.51	22	281405	19688	90327332
Cestode infection	16.63	10.51	11	281416	303	90346717
Breath sounds abnormal	16.60	10.51	14	281413	15372	90331648
Atrioventricular block complete	16.43	10.51	5	281422	9806	90337214
Pleuritic pain	16.35	10.51	6	281421	10455	90336565
Aphasia	16.19	10.51	73	281354	42739	90304281
Weight fluctuation	16.19	10.51	111	281316	19638	90327382
Injection site erythema	16.17	10.51	212	281215	98290	90248730
Blood urea increased	16.09	10.51	45	281382	30368	90316652
Clostridium difficile colitis	16.07	10.51	37	281390	26669	90320351
Erythema multiforme	16.06	10.51	9	281418	12237	90334783
Pulseless electrical activity	15.99	10.51	4	281423	8928	90338092
Gastrointestinal stoma output abnormal	15.94	10.51	12	281415	408	90346612
Tardive dyskinesia	15.89	10.51	7	281420	10923	90336097
Injection site pain	15.88	10.51	414	281013	173285	90173735
Pruritus	15.86	10.51	1917	279510	539608	89807412
Gastric disorder	15.80	10.51	52	281375	33332	90313688
Rectal haemorrhage	15.76	10.51	352	281075	82392	90264628
Renal disorder	15.55	10.51	183	281244	37676	90309344
Platelet count decreased	15.46	10.51	316	281111	136653	90210367
Withdrawal syndrome	15.42	10.51	29	281398	22495	90324525
Apnoea	15.41	10.51	5	281422	9409	90337611
Bacterial infection	15.34	10.51	31	281396	23413	90323607
Diffuse large B-cell lymphoma	15.23	10.51	4	281423	8641	90338379
Enterococcal infection	15.17	10.51	6	281421	9985	90337035
Hypovolaemia	15.10	10.51	10	281417	12421	90334599
Product label confusion	15.08	10.51	122	281305	22728	90324292
Spinal pain	15.07	10.51	16	281411	15751	90331269
Gestational diabetes	15.04	10.51	7	281420	10575	90336445
Electrolyte imbalance	15.03	10.51	32	281395	23713	90323307
Disease recurrence	14.97	10.51	63	281364	37590	90309430
Fear of injection	14.89	10.51	4	281423	8511	90338509
Back disorder	14.88	10.51	133	281294	25498	90321522
Rash	14.88	10.51	2747	278680	793353	89553667
Encephalitis	14.87	10.51	8	281419	11126	90335894
Nasal obstruction	14.80	10.51	28	281399	2584	90344436
Bronchospasm	14.77	10.51	26	281401	20683	90326337
Flank pain	14.76	10.51	23	281404	19199	90327821
Device issue	14.68	10.51	45	281382	29492	90317528
Pre-eclampsia	14.66	10.51	8	281419	11040	90335980
Wrong product administered	14.59	10.51	3	281424	7662	90339358
Hepatomegaly	14.53	10.51	12	281415	13314	90333706
Unintended pregnancy	14.51	10.51	3	281424	7634	90339386
Ileus	14.50	10.51	18	281409	16528	90330492
Nephrolithiasis	14.49	10.51	91	281336	48994	90298026
Myocarditis	14.36	10.51	13	281414	13793	90333227
Dysphonia	14.30	10.51	126	281301	62958	90284062
Injection site pruritus	14.30	10.51	103	281324	53731	90293289
Cytopenia	14.25	10.51	20	281407	17429	90329591
Atrial septal defect	14.15	10.51	4	281423	8230	90338790
Blood immunoglobulin A decreased	14.14	10.51	22	281405	1734	90345286
Intestinal ischaemia	14.05	10.51	5	281422	8878	90338142
Neutrophil count decreased	14.04	10.51	148	281279	71384	90275636
Dermatitis allergic	14.02	10.51	20	281407	17307	90329713
Myositis	13.91	10.51	125	281302	24003	90323017
Gastrointestinal toxicity	13.86	10.51	6	281421	9461	90337559
Biliary tract infection	13.79	10.51	15	281412	829	90346191
Blood lactic acid increased	13.78	10.51	5	281422	8773	90338247
Blood sodium decreased	13.77	10.51	42	281385	27571	90319449
Sarcoidosis	13.77	10.51	8	281419	10665	90336355
Lichen sclerosus	13.76	10.51	19	281408	1344	90345676
Fracture	13.76	10.51	30	281397	22046	90324974
Electrocardiogram QRS complex prolonged	13.73	10.51	3	281424	7345	90339675
Device breakage	13.71	10.51	14	281413	14030	90332990
Paranoia	13.61	10.51	12	281415	12896	90334124
Partial seizures	13.49	10.51	3	281424	7257	90339763
Hyperbilirubinaemia	13.48	10.51	14	281413	13922	90333098
Walking aid user	13.44	10.51	169	281258	35337	90311683
Peripheral sensory neuropathy	13.33	10.51	6	281421	9244	90337776
Blood potassium decreased	13.32	10.51	90	281337	47637	90299383
Pulmonary congestion	13.32	10.51	25	281402	19408	90327612
Acidosis	13.24	10.51	12	281415	12724	90334296
Knee arthroplasty	13.16	10.51	345	281082	82837	90264183
Bone disorder	13.15	10.51	33	281394	23087	90323933
Cushingoid	13.12	10.51	8	281419	10387	90336633
Hypovolaemic shock	13.05	10.51	3	281424	7091	90339929
Hyperthyroidism	13.04	10.51	23	281404	18287	90328733
Inappropriate schedule of product administration	13.02	10.51	360	281067	149573	90197447
Abdominal pain lower	12.94	10.51	49	281378	30128	90316892
Chronic obstructive pulmonary disease	12.83	10.51	157	281270	73672	90273348
Hypotonia	12.82	10.51	10	281417	11416	90335604
Cholangitis infective	12.78	10.51	11	281416	454	90346566
Congenital neuropathy	12.72	10.51	4	281423	16	90347004
Dysuria	12.72	10.51	71	281356	39330	90307690
Brow ptosis	12.69	10.51	10	281417	364	90346656
Gonorrhoea	12.66	10.51	7	281420	138	90346882
Movement disorder	12.52	10.51	47	281380	28972	90318048
Abdominal pain	12.52	10.51	1058	280369	394663	89952357
Alopecia	12.51	10.51	1737	279690	493334	89853686
Cholecystitis	12.51	10.51	21	281406	17019	90330001
Fumbling	12.48	10.51	7	281420	142	90346878
Laryngeal oedema	12.48	10.51	3	281424	6878	90340142
Emotional distress	12.42	10.51	65	281362	36597	90310423
Low birth weight baby	12.35	10.51	7	281420	9460	90337560
Ejection fraction decreased	12.35	10.51	41	281386	26212	90320808
Intracranial pressure increased	12.29	10.51	3	281424	6808	90340212
Thinking abnormal	12.26	10.51	11	281416	11721	90335299
Tumour lysis syndrome	12.21	10.51	10	281417	11142	90335878
Skin toxicity	12.21	10.51	3	281424	6776	90340244
Staphylococcal sepsis	12.16	10.51	7	281420	9376	90337644
Foetal growth restriction	12.15	10.51	7	281420	9373	90337647
Wrong technique in product usage process	12.13	10.51	153	281274	71418	90275602
Neoplasm malignant	12.09	10.51	59	281368	33821	90313199
Tricuspid valve incompetence	11.93	10.51	21	281406	16710	90330310
Device occlusion	11.92	10.51	7	281420	9275	90337745
Congestive cardiomyopathy	11.87	10.51	4	281423	7350	90339670
Streptococcal infection	11.82	10.51	4	281423	7329	90339691
Cardiac disorder	11.81	10.51	245	281182	56627	90290393
Finger deformity	11.79	10.51	155	281272	32742	90314278
Personality change	11.78	10.51	4	281423	7317	90339703
Lymphoma	11.69	10.51	15	281412	13576	90333444
Autoimmune hepatitis	11.69	10.51	9	281418	10342	90336678
Klebsiella infection	11.57	10.51	9	281418	10288	90336732
Arteriosclerosis	11.55	10.51	10	281417	10843	90336177
Device use error	11.53	10.51	4	281423	7217	90339803
Red blood cell sedimentation rate increased	11.50	10.51	337	281090	82258	90264762
Therapeutic product effect decreased	11.46	10.51	1006	280421	276565	90070455
Sleep disorder due to general medical condition, hypersomnia type	11.43	10.51	22	281405	2057	90344963
Femoral neck fracture	11.42	10.51	9	281418	10224	90336796
Upper gastrointestinal haemorrhage	11.42	10.51	35	281392	22941	90324079
Drug dose omission by device	11.42	10.51	9	281418	10222	90336798
Confusional state	11.40	10.51	1368	280059	384837	89962183
Chest pain	11.33	10.51	1146	280281	318499	90028521
Granulocytopenia	11.31	10.51	3	281424	6438	90340582
Speech disorder	11.26	10.51	89	281338	45496	90301524
Endocarditis	11.25	10.51	4	281423	7109	90339911
Muscle twitching	11.24	10.51	38	281389	24164	90322856
Asphyxia	11.23	10.51	4	281423	7099	90339921
Blood immunoglobulin G increased	11.21	10.51	27	281400	2945	90344075
Brain injury	11.18	10.51	5	281422	7733	90339287
Pneumothorax	11.18	10.51	27	281400	19140	90327880
Dyslipidaemia	11.14	10.51	9	281418	10098	90336922
Left atrial volume increased	11.11	10.51	5	281422	62	90346958
Orthostatic hypotension	11.05	10.51	187	281240	41640	90305380
Immune reconstitution inflammatory syndrome	11.02	10.51	4	281423	7015	90340005
Petechiae	11.01	10.51	20	281407	15721	90331299
Generalised oedema	10.99	10.51	27	281400	19026	90327994
Respiratory tract infection	10.89	10.51	124	281303	58954	90288066
Affect lability	10.89	10.51	25	281402	18038	90328982
Nightmare	10.87	10.51	33	281394	21692	90325328
Photophobia	10.86	10.51	32	281395	21237	90325783
Left ventricular dysfunction	10.84	10.51	18	281409	14651	90332369
Diplopia	10.83	10.51	49	281378	28665	90318355
Small intestinal obstruction	10.81	10.51	32	281395	21202	90325818
Blood pressure inadequately controlled	10.74	10.51	3	281424	6221	90340799
Head injury	10.73	10.51	55	281372	31133	90315887
Eosinophil count increased	10.68	10.51	15	281412	13066	90333954
Demyelination	10.65	10.51	6	281421	8134	90338886
Polyarthritis	10.58	10.51	26	281401	18324	90328696
Glomerular filtration rate decreased	10.56	10.51	23	281404	16909	90330111
Toxic encephalopathy	10.56	10.51	7	281420	8692	90338328

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug interaction	152.50	11.23	72	53312	266927	42301024
Toxicity to various agents	148.41	11.23	51	53333	229085	42338866
Coombs positive haemolytic anaemia	121.89	11.23	49	53335	1186	42566765
Appendicolith	118.96	11.23	113	53271	13343	42554608
Appendicitis	90.27	11.23	120	53264	20493	42547458
Blood phosphorus increased	90.04	11.23	94	53290	12431	42555520
Lymphadenitis	88.72	11.23	49	53335	2462	42565489
Constipation	81.34	11.23	410	52974	161881	42406070
Sleep disorder therapy	81.00	11.23	68	53316	6826	42561125
Myasthenia gravis	78.57	11.23	99	53285	16038	42551913
Analgesic therapy	78.00	11.23	65	53319	6459	42561492
Hyperphosphataemia	76.79	11.23	88	53296	12916	42555035
Fatigue	72.85	11.23	849	52535	434792	42133159
Ventricular fibrillation	67.40	11.23	129	53255	29994	42537957
Abdominal distension	66.12	11.23	219	53165	71516	42496435
Completed suicide	64.95	11.23	20	53364	96445	42471506
Drug therapy	63.00	11.23	57	53327	6323	42561628
Blood uric acid increased	62.75	11.23	87	53297	15460	42552491
Neuralgia	61.32	11.23	113	53271	25534	42542417
Iron deficiency	60.55	11.23	72	53312	10989	42556962
Epidural lipomatosis	60.52	11.23	34	53350	1766	42566185
Hypophosphataemia	58.76	11.23	99	53285	20846	42547105
Antacid therapy	58.48	11.23	48	53336	4669	42563282
Anticoagulant therapy	55.91	11.23	46	53338	4489	42563462
Blood cholesterol increased	54.35	11.23	110	53274	26631	42541320
Dry mouth	54.31	11.23	140	53244	39739	42528212
Nasopharyngitis	52.15	11.23	226	53158	83770	42484181
Victim of child abuse	49.85	11.23	26	53358	1163	42566788
Juvenile idiopathic arthritis	48.56	11.23	34	53350	2605	42565346
Bacterial infection	47.79	11.23	107	53277	27772	42540179
Stress	47.17	11.23	142	53242	44070	42523881
Acute kidney injury	47.06	11.23	269	53115	367068	42200883
Thrombosis	45.36	11.23	188	53196	68323	42499628
Intentional overdose	44.24	11.23	6	53378	51450	42516501
Incorrect route of product administration	42.46	11.23	94	53290	24211	42543740
Dry skin	40.51	11.23	143	53241	48195	42519756
Haemolysis	39.20	11.23	54	53330	9535	42558416
Cardiogenic shock	37.57	11.23	114	53270	35526	42532425
Aortic stenosis	36.89	11.23	50	53334	8695	42559256
Swelling	36.63	11.23	151	53233	54734	42513217
Chronic obstructive pulmonary disease	35.54	11.23	165	53219	62949	42505002
Activated partial thromboplastin time prolonged	35.43	11.23	68	53316	15835	42552116
Product dose omission issue	35.23	11.23	321	53063	154044	42413907
Ulcer	35.05	11.23	69	53315	16372	42551579
Rhabdomyolysis	34.77	11.23	28	53356	77991	42489960
Gout	34.66	11.23	95	53289	27960	42539991
Leukopenia	33.09	11.23	27	53357	74719	42493232
Hyperlipidaemia	32.94	11.23	79	53305	21437	42546514
Pruritus	32.75	11.23	371	53013	188400	42379551
Ascites	32.52	11.23	149	53235	56529	42511422
Blood calcium increased	32.17	11.23	46	53338	8408	42559543
Mucosal inflammation	31.87	11.23	11	53373	49363	42518588
Sleep disorder	31.84	11.23	132	53252	47963	42519988
Cardio-respiratory arrest	31.60	11.23	17	53367	58619	42509332
Overdose	31.53	11.23	52	53332	105212	42462739
Intentional product misuse	31.37	11.23	157	53227	61743	42506208
Coma	31.17	11.23	14	53370	53540	42514411
Stiff person syndrome	30.43	11.23	11	53373	197	42567754
Bronchopulmonary aspergillosis allergic	30.38	11.23	33	53351	4565	42563386
Suicide attempt	30.23	11.23	10	53374	46090	42521861
Treatment failure	29.80	11.23	21	53363	62603	42505348
Drug abuse	29.33	11.23	54	53330	104717	42463234
End stage renal disease	28.88	11.23	64	53320	16494	42551457
Muscle swelling	27.98	11.23	13	53371	451	42567500
Migraine	27.45	11.23	82	53302	25332	42542619
Thrombocytopenia	27.27	11.23	134	53250	190145	42377806
Migraine with aura	27.26	11.23	16	53368	903	42567048
Cytomegalovirus infection	27.22	11.23	4	53380	32302	42535649
Drug resistance	27.16	11.23	5	53379	34243	42533708
Iris hypopigmentation	26.81	11.23	7	53377	38	42567913
Renal failure	26.34	11.23	92	53292	143634	42424317
Interstitial lung disease	26.16	11.23	36	53348	78426	42489525
Total lung capacity decreased	26.03	11.23	27	53357	3543	42564408
Full blood count decreased	25.77	11.23	70	53314	20490	42547461
Hypotension	25.74	11.23	203	53181	257428	42310523
Diabetes mellitus	25.39	11.23	145	53239	59942	42508009
Child abuse	25.08	11.23	15	53369	877	42567074
Foetal exposure during pregnancy	25.08	11.23	14	53370	47297	42520654
Sinusitis	24.70	11.23	121	53263	47171	42520780
Injection related reaction	24.49	11.23	13	53371	603	42567348
Pancytopenia	23.91	11.23	72	53312	117671	42450280
Blood test abnormal	23.77	11.23	51	53333	12855	42555096
Corneal opacity	23.56	11.23	13	53371	652	42567299
Hemiparaesthesia	23.53	11.23	9	53375	190	42567761
Septic shock	23.29	11.23	50	53334	91622	42476329
Rhinocerebral mucormycosis	23.11	11.23	13	53371	677	42567274
Keratopathy	22.97	11.23	13	53371	685	42567266
Dermatitis atopic	22.83	11.23	49	53335	12355	42555596
Lactic acidosis	21.76	11.23	15	53369	45246	42522705
Drug reaction with eosinophilia and systemic symptoms	21.52	11.23	13	53371	42062	42525889
Respiratory depression	21.45	11.23	62	53322	18806	42549145
Seasonal allergy	21.18	11.23	37	53347	8018	42559933
Cytokine release syndrome	21.09	11.23	15	53369	44512	42523439
Eosinophilia	20.10	11.23	8	53376	32891	42535060
Dry eye	19.64	11.23	53	53331	15453	42552498
Influenza	19.44	11.23	139	53245	62036	42505915
Sedation	19.31	11.23	7	53377	30468	42537483
Asthenia	19.00	11.23	473	52911	280320	42287631
Lung hernia	18.88	11.23	6	53378	71	42567880
Muscle spasticity	18.80	11.23	32	53352	6790	42561161
Febrile neutropenia	18.68	11.23	146	53238	185557	42382394
Cholestasis	18.50	11.23	9	53375	32870	42535081
Depressed level of consciousness	18.10	11.23	20	53364	47950	42520001
Urinary tract infection	18.04	11.23	197	53187	99087	42468864
Bacteroides infection	17.85	11.23	19	53365	2568	42565383
Hypoaesthesia	17.51	11.23	151	53233	71312	42496639
Tenderness	17.40	11.23	36	53348	8847	42559104
Upper respiratory tract infection	17.31	11.23	101	53283	42072	42525879
Cataract	17.21	11.23	80	53304	30524	42537427
Hyperkalaemia	17.20	11.23	48	53336	80410	42487541
Accidental overdose	17.13	11.23	7	53377	28323	42539628
Aggression	17.12	11.23	18	53366	44145	42523806
Cough	16.85	11.23	315	53069	177788	42390163
Toxic anterior segment syndrome	16.70	11.23	14	53370	1402	42566549
Needle fatigue	16.43	11.23	13	53371	1200	42566751
Micturition urgency	16.43	11.23	42	53342	11856	42556095
Diarrhoea	16.11	11.23	718	52666	460131	42107820
Relapsing-remitting multiple sclerosis	16.04	11.23	14	53370	1481	42566470
Stevens-Johnson syndrome	16.03	11.23	4	53380	22174	42545777
Pneumonia	15.93	11.23	663	52721	421486	42146465
Crystal nephropathy	15.91	11.23	10	53374	639	42567312
Tubulointerstitial nephritis	15.78	11.23	10	53374	31538	42536413
Myocardial infarction	15.71	11.23	91	53293	123918	42444033
Angioedema	15.71	11.23	18	53366	42459	42525492
Madarosis	15.51	11.23	9	53375	497	42567454
Increased tendency to bruise	15.50	11.23	23	53361	4347	42563604
Hot flush	15.30	11.23	62	53322	22289	42545662
Neuroleptic malignant syndrome	15.28	11.23	4	53380	21468	42546483
Plasma cell myeloma	15.24	11.23	107	53277	47471	42520480
Infusion related reaction	15.17	11.23	129	53255	60677	42507274
Metabolic acidosis	15.16	11.23	26	53358	51832	42516119
Peripheral swelling	14.99	11.23	176	53208	90094	42477857
Keratitis viral	14.98	11.23	3	53381	3	42567948
Nocturia	14.94	11.23	41	53343	12071	42555880
Troponin increased	14.78	11.23	55	53329	19007	42548944
Gait spastic	14.73	11.23	13	53371	1396	42566555
Hepatic enzyme increased	14.69	11.23	103	53281	45681	42522270
Renal impairment	14.44	11.23	80	53304	110148	42457803
Flatulence	14.33	11.23	66	53318	25086	42542865
Rhinorrhoea	14.27	11.23	78	53306	31716	42536235
Ischaemic stroke	14.27	11.23	5	53379	22228	42545723
Nausea	14.24	11.23	620	52764	396179	42171772
Neurotoxicity	14.05	11.23	6	53378	23645	42544306
Blood pressure systolic abnormal	14.02	11.23	25	53359	5503	42562448
Lower respiratory tract infection	13.99	11.23	94	53290	41112	42526839
Hyponatraemia	13.94	11.23	191	53193	101271	42466680
Full blood count abnormal	13.89	11.23	74	53310	29802	42538149
Ulcerative keratitis	13.82	11.23	15	53369	2073	42565878
Haemophagocytic lymphohistiocytosis	13.74	11.23	3	53381	18219	42549732
Conjunctival scar	13.72	11.23	7	53377	299	42567652
Corneal disorder	13.60	11.23	11	53373	1048	42566903
Drug level increased	13.53	11.23	8	53376	26192	42541759
COVID-19	13.47	11.23	212	53172	115736	42452215
Corneal exfoliation	13.45	11.23	3	53381	7	42567944
Feeling abnormal	13.38	11.23	140	53244	69646	42498305
Ocular surface squamous neoplasia	13.38	11.23	4	53380	38	42567913
Haemoglobin decreased	13.11	11.23	236	53148	132235	42435716
Musculoskeletal stiffness	13.09	11.23	120	53264	57645	42510306
Taste disorder	13.04	11.23	35	53349	10172	42557779
Cardiac arrest	12.91	11.23	82	53302	109238	42458713
Respiratory arrest	12.91	11.23	10	53374	28414	42539537
Insomnia	12.91	11.23	214	53170	118039	42449912
Joint injury	12.79	11.23	44	53340	14632	42553319
Oesophageal injury	12.79	11.23	6	53378	213	42567738
Hepatotoxicity	12.56	11.23	8	53376	25159	42542792
Insulin autoimmune syndrome	12.54	11.23	8	53376	525	42567426
Fluid retention	12.51	11.23	75	53309	31544	42536407
Weight decreased	12.51	11.23	345	53039	207603	42360348
Skin exfoliation	12.47	11.23	92	53292	41461	42526490
Dizziness	12.42	11.23	404	52980	248850	42319101
Psychotic disorder	12.37	11.23	11	53373	29197	42538754
Hypertonic bladder	12.21	11.23	15	53369	2366	42565585
Throat irritation	12.17	11.23	40	53344	12996	42554955
Therapeutic response shortened	12.13	11.23	41	53343	13513	42554438
Premature baby	12.05	11.23	7	53377	23146	42544805
Pollakiuria	12.05	11.23	58	53326	22447	42545504
Sudden death	12.02	11.23	3	53381	16626	42551325
Muscle spasms	11.83	11.23	162	53222	85882	42482069
Benign prostatic hyperplasia	11.81	11.23	55	53329	20997	42546954
Conjunctival hyperaemia	11.67	11.23	17	53367	3159	42564792
Hepatic cytolysis	11.50	11.23	10	53374	26834	42541117
Electrocardiogram QT prolonged	11.48	11.23	27	53357	47918	42520033
Pain	11.47	11.23	394	52990	244454	42323497
Agranulocytosis	11.29	11.23	13	53371	30599	42537352

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	651.49	10.82	215	285525	480340	109823219
Drug interaction	617.32	10.82	260	285480	499923	109803636
Acute kidney injury	567.76	10.82	485	285255	634945	109668614
Rheumatoid arthritis	527.41	10.82	1838	283902	297775	110005784
Rheumatic fever	512.97	10.82	1039	284701	121540	110182019
Completed suicide	499.71	10.82	32	285708	242349	110061210
Night sweats	436.78	10.82	1027	284713	132956	110170603
Fibromyalgia	428.28	10.82	1186	284554	169723	110133836
Bursitis	426.96	10.82	999	284741	128919	110174640
Psoriatic arthropathy	412.27	10.82	1281	284459	195480	110108079
Lip dry	411.19	10.82	842	284898	99241	110204318
Type 2 diabetes mellitus	374.17	10.82	1157	284583	176075	110127484
Peripheral venous disease	358.99	10.82	719	285021	83398	110220161
Swollen joint count increased	353.33	10.82	712	285028	82949	110220610
Joint range of motion decreased	342.07	10.82	882	284858	120950	110182609
Blood cholesterol increased	330.39	10.82	1140	284600	183645	110119914
Facet joint syndrome	326.23	10.82	752	284988	96076	110207483
Duodenal ulcer perforation	323.57	10.82	1103	284637	176597	110126962
Irritable bowel syndrome	322.77	10.82	1046	284694	163169	110140390
Folliculitis	318.85	10.82	1056	284684	166597	110136962
Helicobacter infection	317.31	10.82	1113	284627	180764	110122795
Dry mouth	310.37	10.82	1178	284562	198770	110104789
Impaired healing	310.34	10.82	1165	284575	195552	110108007
Muscle injury	308.16	10.82	931	284809	139876	110163683
C-reactive protein abnormal	301.39	10.82	876	284864	128819	110174740
Wound	289.47	10.82	1287	284453	233150	110070409
Injury	288.96	10.82	1061	284679	176204	110127355
Temperature regulation disorder	286.38	10.82	249	285491	12577	110290982
Liver injury	284.74	10.82	946	284794	149467	110154092
Infusion related reaction	274.55	10.82	1805	283935	379357	109924202
Road traffic accident	273.59	10.82	750	284990	106648	110196911
Prescribed overdose	273.10	10.82	660	285080	86921	110216638
Lower limb fracture	272.56	10.82	602	285138	74746	110228813
Pemphigus	272.52	10.82	1188	284552	213382	110090177
Mobility decreased	272.01	10.82	1275	284465	236147	110067412
Deep vein thrombosis postoperative	271.38	10.82	522	285218	58769	110244790
Glossodynia	269.74	10.82	1213	284527	220791	110082768
Pericarditis	260.08	10.82	1189	284551	217925	110085634
Hepatic enzyme increased	254.83	10.82	1558	284182	319334	109984225
Neutropenia	254.51	10.82	358	285382	374262	109929297
Intentional overdose	252.11	10.82	25	285715	132476	110171083
Cardiac arrest	244.44	10.82	101	285639	196652	110106907
Sleep disorder due to general medical condition, insomnia type	243.93	10.82	712	285028	104931	110198628
Ill-defined disorder	243.26	10.82	924	284816	155929	110147630
Hypotension	242.65	10.82	630	285110	523219	109780340
Hand deformity	241.96	10.82	1162	284578	217344	110086215
Rheumatoid factor positive	241.23	10.82	819	284921	130821	110172738
Urticaria	239.36	10.82	1526	284214	317331	109986228
Autoimmune disorder	238.90	10.82	525	285215	64958	110238601
Sciatica	236.08	10.82	646	285094	91753	110211806
Renal failure	235.62	10.82	147	285593	226427	110077132
Joint swelling	232.25	10.82	1945	283795	440900	109862659
Obesity	230.83	10.82	731	285009	112620	110190939
Sleep disorder	229.86	10.82	1070	284670	197574	110105985
Food allergy	225.45	10.82	268	285472	19680	110283879
Blister	224.10	10.82	1170	284570	226206	110077353
Gait inability	219.45	10.82	813	284927	135563	110167996
Sinusitis	218.41	10.82	1413	284327	295275	110008284
Pancytopenia	217.95	10.82	136	285604	209477	110094082
Hypoaesthesia	217.11	10.82	1473	284267	312750	109990809
Systemic lupus erythematosus	214.08	10.82	1254	284486	253084	110050475
Febrile neutropenia	213.84	10.82	304	285436	316463	109987096
Coeliac disease	212.26	10.82	392	285348	42795	110260764
Asthma	211.28	10.82	1235	284505	249056	110054503
Lower respiratory tract infection	205.49	10.82	1200	284540	241906	110061653
Stomatitis	203.16	10.82	1294	284446	268948	110034611
Anti-cyclic citrullinated peptide antibody positive	202.32	10.82	969	284771	181015	110122544
Drug abuse	197.40	10.82	106	285634	177305	110126254
Osteoarthritis	196.26	10.82	963	284777	181660	110121899
Septic shock	193.83	10.82	82	285658	157446	110146113
Wound infection	193.57	10.82	619	285121	95846	110207713
Taste disorder	191.38	10.82	481	285259	64906	110238653
Cardio-respiratory arrest	189.31	10.82	35	285705	115801	110187758
Rhabdomyolysis	187.13	10.82	41	285699	120360	110183199
Synovitis	184.62	10.82	1277	284463	272815	110030744
Wheezing	178.96	10.82	1201	284539	254029	110049530
Suicide attempt	178.37	10.82	27	285713	103367	110200192
Musculoskeletal pain	177.69	10.82	938	284802	182085	110121474
Live birth	176.69	10.82	485	285255	68999	110234560
Breast cancer stage III	176.68	10.82	527	285213	78590	110224969
Contraindicated product administered	176.33	10.82	1172	284568	247095	110056464
Nasopharyngitis	169.34	10.82	1659	284081	392702	109910857
Abdominal pain upper	168.59	10.82	1506	284234	347605	109955954
Lupus vulgaris	167.07	10.82	308	285432	33575	110269984
Immunodeficiency	166.87	10.82	333	285407	38505	110265054
Swelling	166.80	10.82	1509	284231	349532	109954027
Peripheral swelling	165.42	10.82	1683	284057	402351	109901208
Renal impairment	165.26	10.82	146	285594	188299	110115260
Hyperkalaemia	164.98	10.82	72	285668	135724	110167835
Sensitisation	163.83	10.82	113	285627	4038	110299521
X-ray abnormal	162.79	10.82	326	285414	37791	110265768
Lung disorder	156.83	10.82	896	284844	179151	110124408
Cardiac failure	155.53	10.82	153	285587	187473	110116086
C-reactive protein	153.71	10.82	279	285461	30052	110273507
Seizure	150.48	10.82	211	285529	220974	110082585
Myocardial infarction	149.79	10.82	165	285575	191918	110111641
Interstitial lung disease	149.58	10.82	87	285653	139247	110164312
Polycystic ovaries	149.18	10.82	113	285627	4683	110298876
Lactic acidosis	147.52	10.82	30	285710	92781	110210778
Blepharospasm	143.59	10.82	387	285353	54464	110249095
Hypercholesterolaemia	143.15	10.82	538	285202	90299	110213260
Ear pain	142.83	10.82	379	285361	52847	110250712
Arthropathy	142.73	10.82	1248	284492	286274	110017285
Weight increased	140.54	10.82	1680	284060	417964	109885595
Respiratory failure	135.26	10.82	217	285523	215115	110088444
Drug ineffective	135.23	10.82	2950	282790	1517590	108785969
Migraine	135.19	10.82	832	284908	170820	110132739
Adverse event	133.89	10.82	597	285143	108212	110195347
Gastrooesophageal reflux disease	132.84	10.82	858	284882	179118	110124441
Ejection fraction	132.33	10.82	87	285653	2868	110300691
Inflammation	132.23	10.82	904	284836	192334	110111225
Metabolic acidosis	130.82	10.82	47	285693	99697	110203862
Angioedema	129.89	10.82	46	285694	98454	110205105
Drug reaction with eosinophilia and systemic symptoms	129.52	10.82	27	285713	82068	110221491
Retinitis	129.20	10.82	269	285471	32058	110271501
Bradycardia	128.67	10.82	127	285613	155390	110148169
Anaemia	128.24	10.82	857	284883	546229	109757330
Electrocardiogram QT prolonged	127.32	10.82	61	285679	108899	110194660
Disease progression	126.73	10.82	276	285464	243758	110059801
Mucosal inflammation	124.90	10.82	46	285694	96095	110207464
Treatment failure	124.69	10.82	1178	284562	276056	110027503
Grip strength decreased	122.33	10.82	470	285270	79704	110223855
Alopecia	121.98	10.82	1460	284280	363293	109940266
Onychomadesis	121.36	10.82	324	285416	45339	110258220
Liver disorder	121.31	10.82	704	285036	141539	110162020
Muscle spasms	118.73	10.82	1169	284571	276988	110026571
Hypersensitivity	117.62	10.82	1576	284164	402422	109901137
Abdominal discomfort	115.72	10.82	1539	284201	392319	109911240
Pain	114.38	10.82	3252	282488	951703	109351856
Muscle spasticity	113.36	10.82	272	285468	35643	110267916
Cholestasis	113.24	10.82	16	285724	64502	110239057
Death	112.34	10.82	1209	284531	697660	109605899
Adjustment disorder with depressed mood	112.24	10.82	307	285433	43576	110259983
Musculoskeletal stiffness	112.22	10.82	1161	284579	278661	110024898
Hypokalaemia	110.72	10.82	188	285552	182260	110121299
Discomfort	109.67	10.82	938	284802	213769	110089790
Loss of consciousness	109.56	10.82	213	285527	196093	110107466
Gastrointestinal disorder	108.24	10.82	1027	284713	240925	110062634
Hypoglycaemia	107.88	10.82	85	285655	116019	110187540
Insomnia	106.73	10.82	1411	284329	359179	109944380
Serotonin syndrome	105.41	10.82	14	285726	59139	110244420
Thrombocytopenia	105.27	10.82	503	285237	348382	109955177
Cytokine release syndrome	105.15	10.82	26	285714	70280	110233279
Eosinophilia	104.96	10.82	13	285727	57923	110245636
Anti-cyclic citrullinated peptide antibody	104.17	10.82	186	285554	19778	110283781
Laryngitis	103.83	10.82	292	285448	42119	110261440
Hepatocellular injury	103.38	10.82	7	285733	50635	110252924
Dislocation of vertebra	102.15	10.82	296	285444	43425	110260134
Chronic sinusitis	101.73	10.82	210	285530	24874	110278685
Memory impairment	99.84	10.82	859	284881	196085	110107474
Product quality issue	98.80	10.82	429	285311	76870	110226689
Syncope	98.72	10.82	237	285503	202299	110101260
Malignant neoplasm progression	97.77	10.82	189	285551	174378	110129181
Dyspepsia	97.37	10.82	834	284906	190131	110113428
Contusion	96.78	10.82	975	284765	232386	110071173
Intentional product use issue	96.75	10.82	1023	284717	246883	110056676
Cytomegalovirus infection	96.74	10.82	13	285727	54431	110249128
Maternal exposure timing unspecified	93.68	10.82	183	285557	20830	110282729
Hepatic cytolysis	93.53	10.82	15	285725	55038	110248521
Upper respiratory tract infection	93.18	10.82	620	285120	130708	110172851
Myelosuppression	92.90	10.82	65	285675	94275	110209284
Drug hypersensitivity	90.79	10.82	1663	284077	452427	109851132
Vaginal flatulence	90.48	10.82	133	285607	12011	110291548
Leukopenia	88.74	10.82	155	285585	148636	110154923
Suicidal ideation	88.25	10.82	68	285672	93869	110209690
Ulcer haemorrhage	88.07	10.82	186	285554	22385	110281174
Exostosis	87.74	10.82	290	285450	45666	110257893
Tubulointerstitial nephritis	87.41	10.82	17	285723	54267	110249292
Respiratory disorder	87.31	10.82	391	285349	70991	110232568
Agranulocytosis	86.43	10.82	26	285714	61734	110241825
Frequent bowel movements	85.79	10.82	389	285351	71001	110232558
Macular degeneration	85.11	10.82	179	285561	21480	110282079
Encephalopathy	85.03	10.82	52	285688	81003	110222556
Lupus-like syndrome	84.77	10.82	265	285475	40527	110263032
Sepsis	83.70	10.82	499	285241	326847	109976712
Fluid retention	83.17	10.82	471	285269	93836	110209723
Rash maculo-papular	83.04	10.82	44	285696	74178	110229381
Paraesthesia	83.02	10.82	1085	284655	275436	110028123
Agitation	79.73	10.82	105	285635	112946	110190613
Alanine aminotransferase increased	78.94	10.82	229	285511	183544	110120015
Nail disorder	78.26	10.82	327	285413	57608	110245951
Ventricular tachycardia	77.76	10.82	17	285723	49992	110253567
Prescribed underdose	77.47	10.82	354	285386	64820	110238739
Coombs positive haemolytic anaemia	76.94	10.82	49	285691	1528	110302031
Dehydration	76.89	10.82	416	285324	279095	110024464
Therapeutic product effect decreased	76.86	10.82	967	284773	243349	110060210
Hepatic failure	76.53	10.82	41	285699	68698	110234861
Respiratory arrest	75.55	10.82	28	285712	58271	110245288
Foetal death	75.54	10.82	143	285597	15902	110287657
Ischaemic stroke	75.38	10.82	9	285731	41254	110262305
Hip arthroplasty	75.37	10.82	315	285425	55498	110248061
Tachycardia	74.79	10.82	316	285424	226329	110077230
Bone marrow failure	74.60	10.82	28	285712	57820	110245739
Hypertension	74.49	10.82	1784	283956	508300	109795259
Pregnancy	74.34	10.82	295	285445	50772	110252787
Aggression	74.14	10.82	30	285710	59180	110244379
Product use issue	73.68	10.82	1173	284567	310522	109993037
Atrial fibrillation	73.44	10.82	324	285416	229318	110074241
Disorientation	73.21	10.82	46	285694	70625	110232934
Headache	72.30	10.82	2875	282865	879502	109424057
Psychotic disorder	72.09	10.82	21	285719	50916	110252643
Bone erosion	70.86	10.82	272	285468	46099	110257460
Hypoxia	70.12	10.82	143	285597	129372	110174187
Maternal exposure during pregnancy	69.89	10.82	984	284756	253899	110049660
Hallucination	68.72	10.82	97	285643	101335	110202224
Liver function test abnormal	68.56	10.82	47	285693	68903	110234656
Neurotoxicity	68.42	10.82	13	285727	42194	110261365
Anaphylactic reaction	68.22	10.82	119	285621	114181	110189378
International normalised ratio increased	68.21	10.82	74	285666	86698	110216861
Carpal tunnel syndrome	67.90	10.82	168	285572	22442	110281117
Proctitis	67.81	10.82	141	285599	16786	110286773
Drug resistance	66.72	10.82	31	285709	56343	110247216
Female genital tract fistula	66.64	10.82	138	285602	16381	110287178
Constipation	66.53	10.82	1296	284444	356490	109947069
Acute myocardial infarction	66.35	10.82	71	285669	83706	110219853
Intentional self-injury	66.35	10.82	9	285731	37420	110266139
Blood creatinine increased	66.05	10.82	246	285494	182643	110120916
Melaena	65.57	10.82	49	285691	68708	110234851
Breast cancer stage II	65.56	10.82	187	285553	27188	110276371
Hepatic cirrhosis	65.17	10.82	346	285394	67280	110236279
Generalised tonic-clonic seizure	64.82	10.82	30	285710	54650	110248909
Vaginal discharge	64.64	10.82	143	285597	17765	110285794
Rhinitis allergic	64.56	10.82	143	285597	17779	110285780
Multiple organ dysfunction syndrome	64.46	10.82	190	285550	151520	110152039
Exposure during pregnancy	64.40	10.82	689	285051	166735	110136824
Ejection fraction abnormal	63.17	10.82	60	285680	3400	110300159
Hypomagnesaemia	62.95	10.82	39	285701	60331	110243228
Oedema	62.62	10.82	823	284917	209153	110094406
Haemophagocytic lymphohistiocytosis	62.59	10.82	5	285735	31554	110272005
Coma	62.25	10.82	132	285608	117737	110185822
Back injury	62.05	10.82	265	285475	47134	110256425
Sleep disorder due to a general medical condition	61.90	10.82	283	285457	51829	110251730
Stevens-Johnson syndrome	61.66	10.82	22	285718	46879	110256680
Blood test abnormal	61.65	10.82	188	285552	28366	110275193
Pulmonary embolism	61.32	10.82	315	285425	214159	110089400
Neuroleptic malignant syndrome	60.83	10.82	8	285732	34051	110269508
Drug level increased	60.04	10.82	24	285716	47695	110255864
Gastrointestinal haemorrhage	59.53	10.82	223	285517	165295	110138264
Toxic anterior segment syndrome	59.48	10.82	58	285682	3396	110300163
Poisoning	59.48	10.82	4	285736	29101	110274458
Hepatotoxicity	59.41	10.82	46	285694	63354	110240205
Altered state of consciousness	59.02	10.82	38	285702	57588	110245971
Haematuria	58.63	10.82	77	285663	82928	110220631
Therapeutic product effect incomplete	58.55	10.82	857	284883	222948	110080611
Tremor	58.40	10.82	296	285444	201936	110101623
Pneumocystis jirovecii pneumonia	58.00	10.82	19	285721	42716	110260843
Blood creatine phosphokinase increased	57.80	10.82	62	285678	73015	110230544
Acute hepatic failure	57.51	10.82	12	285728	36456	110267103
Respiratory distress	57.24	10.82	56	285684	68818	110234741
Sedation complication	56.97	10.82	145	285595	19710	110283849
Pleural effusion	56.65	10.82	251	285489	177458	110126101
Drug ineffective for unapproved indication	56.14	10.82	113	285627	102725	110200834
Posterior reversible encephalopathy syndrome	55.81	10.82	10	285730	33851	110269708
Knee arthroplasty	55.70	10.82	322	285418	64626	110238933
Anaphylactic shock	55.57	10.82	32	285708	51514	110252045
Shock	55.35	10.82	35	285705	53553	110250006
Hepatic function abnormal	55.09	10.82	91	285649	89204	110214355
Therapy partial responder	54.85	10.82	14	285726	37047	110266512
Cerebrovascular accident	54.84	10.82	261	285479	181023	110122536
Pulmonary fibrosis	54.83	10.82	451	285289	101591	110201968
Aspartate aminotransferase increased	54.62	10.82	220	285520	159716	110143843
Labelled drug-drug interaction medication error	54.51	10.82	6	285734	29296	110274263
Nephrectomy	54.44	10.82	49	285691	2591	110300968
Radiculopathy	54.23	10.82	140	285600	19196	110284363
Circulatory collapse	53.48	10.82	22	285718	42971	110260588
Creatinine renal clearance decreased	53.20	10.82	150	285590	21665	110281894
Blood bilirubin increased	53.12	10.82	71	285669	75901	110227658
Status epilepticus	52.74	10.82	9	285731	31562	110271997
Poisoning deliberate	52.71	10.82	4	285736	26327	110277232
Paraesthesia oral	52.68	10.82	199	285541	33472	110270087
Onychomycosis	52.44	10.82	218	285522	38313	110265246
Hyponatraemia	52.38	10.82	338	285402	217315	110086244
Pulmonary oedema	52.09	10.82	114	285626	100545	110203014
Appendicolith	51.64	10.82	114	285626	14141	110289418
Cardiac failure congestive	50.75	10.82	209	285531	150791	110152768
Accidental overdose	50.65	10.82	36	285704	51798	110251761
Hyperglycaemia	50.40	10.82	89	285651	85001	110218558
Hypocalcaemia	50	10.82	57	285683	65309	110238250
Hypothermia	49.92	10.82	5	285735	26297	110277262
Toxic epidermal necrolysis	49.64	10.82	44	285696	56683	110246876
Polyneuropathy	49.53	10.82	11	285729	32001	110271558
Dysphagia	49.53	10.82	216	285524	153384	110150175
Unresponsive to stimuli	49.48	10.82	55	285685	63735	110239824
Incorrect route of product administration	49.45	10.82	309	285431	63752	110239807
Colitis ulcerative	49.40	10.82	356	285384	77007	110226552
Thrombotic microangiopathy	49.39	10.82	8	285732	29141	110274418
Haematemesis	49.19	10.82	48	285692	59060	110244499
Transaminases increased	48.79	10.82	55	285685	63335	110240224
Acute respiratory distress syndrome	48.09	10.82	40	285700	53158	110250401
Hallucination, visual	48.09	10.82	21	285719	39584	110263975
Myoclonus	47.82	10.82	13	285727	32985	110270574
Deep vein thrombosis	47.40	10.82	193	285547	139694	110163865
Haemodynamic instability	47.20	10.82	3	285737	22885	110280674
Drug intolerance	46.68	10.82	1378	284362	405134	109898425
Therapy non-responder	46.65	10.82	616	285124	156691	110146868
Ear infection	46.20	10.82	299	285441	62433	110241126
Pneumonia	45.98	10.82	1826	283914	874888	109428671
Aspergillus infection	45.79	10.82	6	285734	25610	110277949
Swollen tongue	45.78	10.82	53	285687	60309	110243250
Arrhythmia	45.68	10.82	68	285672	69507	110234052
Cough	44.72	10.82	882	284858	460759	109842800
Haematoma	44.72	10.82	51	285689	58425	110245134
Rash erythematous	44.67	10.82	363	285377	81469	110222090
Mental status changes	43.85	10.82	81	285659	76041	110227518
Porphyria acute	43.73	10.82	127	285613	18653	110284906
Transplant rejection	43.33	10.82	6	285734	24561	110278998
Somnolence	42.81	10.82	527	285213	296922	110006637
Haematotoxicity	42.78	10.82	3	285737	21079	110282480
Lupus vasculitis	42.64	10.82	24	285716	594	110302965
Dyskinesia	42.55	10.82	42	285698	51404	110252155
Oxygen saturation decreased	42.40	10.82	235	285505	156747	110146812
Drug eruption	41.91	10.82	46	285694	53613	110249946
Pneumonitis	41.85	10.82	84	285656	76447	110227112
Schizophrenia	41.81	10.82	4	285736	21822	110281737
Jaundice	41.78	10.82	55	285685	59181	110244378
Myalgia	41.37	10.82	371	285369	222010	110081549
Pallor	41.31	10.82	51	285689	56416	110247143
Metastases to liver	41.04	10.82	20	285720	35366	110268193
Inappropriate antidiuretic hormone secretion	41.02	10.82	18	285722	33833	110269726
Walking aid user	40.73	10.82	150	285590	24925	110278634
Hypocholesterolaemia	40.36	10.82	65	285675	6356	110297203
Dystonia	39.66	10.82	9	285731	25796	110277763
Abnormal behaviour	39.63	10.82	26	285714	39013	110264546
Pancreatitis acute	39.49	10.82	59	285681	60215	110243344
Acute generalised exanthematous pustulosis	38.90	10.82	5	285735	21659	110281900
Extrapyramidal disorder	38.88	10.82	13	285727	28854	110274705
Cerebral infarction	38.79	10.82	46	285694	51792	110251767
Subdural haematoma	38.77	10.82	23	285717	36431	110267128
Disturbance in attention	38.41	10.82	63	285677	61932	110241627
Sinus tachycardia	38.35	10.82	35	285705	44458	110259101
Aplastic anaemia	38.33	10.82	8	285732	24300	110279259
Sleep disorder therapy	38.20	10.82	69	285671	7402	110296157
Procedural pain	37.77	10.82	187	285553	35378	110268181
Urinary retention	37.66	10.82	77	285663	69606	110233953
Keratopathy	37.60	10.82	30	285710	1343	110302216
Rash	37.55	10.82	2531	283209	818433	109485126
Hypercalcaemia	37.55	10.82	39	285701	46618	110256941
Dysarthria	37.46	10.82	103	285637	84018	110219541
Epilepsy	37.41	10.82	410	285330	99799	110203760
Body temperature increased	37.41	10.82	256	285484	54457	110249102
Miosis	37.32	10.82	6	285734	21977	110281582
Dyspnoea	37.08	10.82	2414	283326	1104458	109199101
Epstein-Barr virus infection	37.08	10.82	3	285737	18735	110284824
Angina pectoris	37.04	10.82	65	285675	62230	110241329
Swollen joint count	36.81	10.82	74	285666	8600	110294959
Osteonecrosis of jaw	36.59	10.82	42	285698	47975	110255584
Gamma-glutamyltransferase increased	36.42	10.82	64	285676	61245	110242314
Osteonecrosis	36.30	10.82	21	285719	33720	110269839
Psoriasis	36.17	10.82	535	285205	139458	110164101
Bronchopulmonary aspergillosis	35.99	10.82	16	285724	29847	110273712
Cerebral haemorrhage	35.79	10.82	71	285669	64897	110238662
Joint dislocation	35.76	10.82	179	285561	34011	110269548
Face oedema	35.76	10.82	21	285719	33448	110270111
Subcutaneous drug absorption impaired	35.73	10.82	68	285672	7591	110295968
Psychomotor hyperactivity	35.65	10.82	5	285735	20272	110283287
Analgesic therapy	35.64	10.82	66	285674	7218	110296341
Infection	35.58	10.82	1205	284535	360995	109942564
Peritonitis	35.50	10.82	20	285720	32587	110270972
Body tinea	35.46	10.82	35	285705	2080	110301479
Fatigue	35.37	10.82	3622	282118	1212336	109091223
Nervous system disorder	35.19	10.82	19	285721	31702	110271857
Tachypnoea	35.15	10.82	30	285710	39365	110264194
Disability	35.05	10.82	163	285577	30060	110273499
Disseminated intravascular coagulation	34.97	10.82	33	285707	41253	110262306
Blood calcium decreased	34.94	10.82	184	285556	35661	110267898
Neutropenic sepsis	34.72	10.82	18	285722	30728	110272831
Blood pressure decreased	34.63	10.82	166	285574	114925	110188634
Toxic skin eruption	34.35	10.82	14	285726	27501	110276058
Epidural lipomatosis	34.28	10.82	34	285706	2033	110301526
Chronic kidney disease	34.28	10.82	93	285647	76198	110227361
Underdose	34.19	10.82	281	285459	63273	110240286
Myelodysplastic syndrome	34.11	10.82	28	285712	37456	110266103
Diabetic ketoacidosis	34.03	10.82	35	285705	42023	110261536
Febrile bone marrow aplasia	34.00	10.82	3	285737	17462	110286097
Blood phosphorus increased	33.81	10.82	106	285634	16234	110287325
Acute coronary syndrome	33.69	10.82	9	285731	23103	110280456
Blood lactate dehydrogenase increased	33.54	10.82	39	285701	44295	110259264
Pruritus	33.51	10.82	1830	283910	579730	109723829
Overlap syndrome	33.44	10.82	73	285667	8986	110294573
Escherichia infection	33.37	10.82	10	285730	23806	110279753
Coronary artery disease	33.27	10.82	86	285654	71604	110231955
Coagulopathy	33.15	10.82	34	285706	40877	110262682
Akathisia	33.15	10.82	3	285737	17110	110286449
Hyperbilirubinaemia	33.12	10.82	19	285721	30652	110272907
Multiple fractures	32.96	10.82	72	285668	8868	110294691
Anuria	32.72	10.82	11	285729	24330	110279229
Haemorrhage intracranial	32.66	10.82	17	285723	28952	110274607
Palpitations	32.58	10.82	259	285481	158953	110144606
Lymphadenopathy	32.45	10.82	73	285667	63762	110239797
Progressive multifocal leukoencephalopathy	32.31	10.82	12	285728	24944	110278615
Victim of child abuse	32.18	10.82	26	285714	1185	110302374
Foot deformity	32.06	10.82	225	285515	48255	110255304
Muscle rigidity	32.06	10.82	11	285729	24020	110279539
Tumour lysis syndrome	31.97	10.82	20	285720	30781	110272778
Pathogen resistance	31.92	10.82	4	285736	17668	110285891
Creatinine renal clearance increased	31.90	10.82	43	285697	3582	110299977
Oliguria	31.88	10.82	5	285735	18652	110284907
Nightmare	31.83	10.82	32	285708	38831	110264728
Hepatitis cholestatic	31.67	10.82	4	285736	17562	110285997
Acute myeloid leukaemia	31.65	10.82	31	285709	38079	110265480
Product administration error	31.22	10.82	30	285710	37187	110266372
Bronchiectasis	31.10	10.82	29	285711	36464	110267095
Sinus bradycardia	30.80	10.82	19	285721	29464	110274095
Device expulsion	30.78	10.82	21	285719	30870	110272689
Adverse drug reaction	30.72	10.82	412	285328	105147	110198412
Sleep apnoea syndrome	30.53	10.82	194	285546	40253	110263306
Cholelithiasis	30.27	10.82	75	285665	63347	110240212
Deafness transitory	30.18	10.82	24	285716	1069	110302490
General physical health deterioration	30.02	10.82	1365	284375	423930	109879629
Diabetes mellitus inadequate control	29.99	10.82	20	285720	29755	110273804
Parkinsonism	29.87	10.82	10	285730	22177	110281382
Subarachnoid haemorrhage	29.86	10.82	20	285720	29682	110273877
Haemoptysis	29.84	10.82	90	285650	71264	110232295
Lymphadenitis	29.72	10.82	52	285688	5441	110298118
Hyperthermia	29.68	10.82	9	285731	21263	110282296
Osteoporosis	29.57	10.82	350	285390	86802	110216757
Rheumatoid nodule	29.40	10.82	8	285732	20288	110283271
Haemorrhage	29.20	10.82	159	285581	106533	110197026
Incorrect dose administered	29.17	10.82	153	285587	103488	110200071
Hallucination, auditory	29.01	10.82	16	285724	26381	110277178
Joint stiffness	28.83	10.82	283	285457	66960	110236599
Hemiparesis	28.73	10.82	43	285697	43860	110259699
Immune reconstitution inflammatory syndrome	28.53	10.82	4	285736	16222	110287337
Skin necrosis	28.43	10.82	10	285730	21502	110282057
Myocardial ischaemia	28.15	10.82	17	285723	26667	110276892
Red blood cell sedimentation rate increased	28.15	10.82	318	285422	77984	110225575
Infusion site reaction	28.07	10.82	105	285635	17577	110285982
Shock haemorrhagic	27.86	10.82	18	285722	27229	110276330
Leukocytosis	27.82	10.82	61	285679	53767	110249792
Injection site reaction	27.75	10.82	352	285388	88718	110214841
Adverse reaction	27.55	10.82	150	285590	29444	110274115
Haemolytic anaemia	27.18	10.82	10	285730	20910	110282649
Panniculitis	27.03	10.82	4	285736	15578	110287981
Neutrophil count decreased	27.00	10.82	192	285548	120749	110182810
Nephropathy toxic	26.96	10.82	19	285721	27459	110276100
Neuropathy peripheral	26.78	10.82	315	285425	178962	110124597
Staphylococcal infection	26.62	10.82	92	285648	69852	110233707
Chills	26.53	10.82	340	285400	190240	110113319
Treatment noncompliance	26.45	10.82	98	285642	72892	110230667
Presyncope	26.44	10.82	54	285686	48833	110254726
Myopathy	26.19	10.82	16	285724	24944	110278615
Drug withdrawal syndrome	26.16	10.82	36	285704	38018	110265541
Drug therapy	26.07	10.82	58	285682	7233	110296326
Enterococcal infection	26.02	10.82	10	285730	20356	110283203
Epistaxis	25.79	10.82	214	285526	130158	110173401
Tuberculosis	25.76	10.82	7	285733	17767	110285792
Clostridium difficile colitis	25.73	10.82	46	285694	43732	110259827
Infection susceptibility increased	25.59	10.82	43	285697	4355	110299204
Lung infiltration	25.55	10.82	16	285724	24612	110278947
Prostate cancer	25.49	10.82	36	285704	37605	110265954
Right ventricular failure	25.39	10.82	18	285722	25936	110277623
Weight fluctuation	25.36	10.82	119	285621	22026	110281533
Product label confusion	25.35	10.82	121	285619	22556	110281003
Premature delivery	25.34	10.82	25	285715	30607	110272952
Sudden death	25.10	10.82	16	285724	24379	110279180
Hyperammonaemia	25.07	10.82	3	285737	13729	110289830
Renal tubular necrosis	25.06	10.82	25	285715	30450	110273109
Mydriasis	24.98	10.82	13	285727	22144	110281415
Pericardial effusion	24.77	10.82	71	285669	57146	110246413
General symptom	24.76	10.82	64	285676	8782	110294777
Antacid therapy	24.74	10.82	48	285692	5436	110298123
Adrenal insufficiency	24.51	10.82	45	285695	42345	110261214
Proteinuria	24.48	10.82	41	285699	39977	110263582
Tenosynovitis	24.39	10.82	6	285734	16277	110287282
Hepatitis acute	24.33	10.82	9	285731	18757	110284802
C-reactive protein increased	24.25	10.82	736	285004	217183	110086376
Cardiac murmur	24.20	10.82	17	285723	24611	110278948
Nail bed inflammation	24.14	10.82	28	285712	2002	110301557
Nasal mucosal disorder	24.14	10.82	27	285713	1856	110301703
Overdose	24.05	10.82	442	285298	233352	110070207
Atrioventricular block first degree	23.88	10.82	4	285736	14221	110289338
Mania	23.75	10.82	12	285728	20784	110282775
BK virus infection	23.59	10.82	3	285737	13103	110290456
Gastroenteritis	23.51	10.82	40	285700	38760	110264799
Myasthenia gravis	23.48	10.82	114	285626	21397	110282162
Vertigo	23.47	10.82	130	285610	86740	110216819
Electrocardiogram QRS complex prolonged	23.39	10.82	3	285737	13018	110290541
Fall	23.35	10.82	1298	284442	602184	109701375
Myocarditis	23.21	10.82	26	285714	30029	110273530
Anticoagulant therapy	23.06	10.82	46	285694	5315	110298244
Spondylitis	22.95	10.82	73	285667	11265	110292294
Cardiomegaly	22.72	10.82	25	285715	29105	110274454
Finger deformity	22.72	10.82	155	285585	32937	110270622
Electrolyte imbalance	22.59	10.82	38	285702	36990	110266569
Blood glucose increased	22.51	10.82	226	285514	132270	110171289
Tardive dyskinesia	22.40	10.82	4	285736	13575	110289984
Renal function test abnormal	22.29	10.82	62	285678	8884	110294675
Klebsiella infection	22.18	10.82	12	285728	19997	110283562
Platelet count decreased	22.06	10.82	441	285299	230002	110073557
Liver function test increased	21.94	10.82	336	285404	88212	110215347
Asphyxia	21.76	10.82	5	285735	14210	110289349
Hyperphosphataemia	21.76	10.82	92	285648	16289	110287270
Diffuse large B-cell lymphoma	21.69	10.82	7	285733	15891	110287668
Stoma site dermatitis	21.69	10.82	12	285728	287	110303272
Hepatic steatosis	21.58	10.82	60	285680	48771	110254788
Gastric ulcer	21.53	10.82	44	285696	39783	110263776
Delusion	21.30	10.82	18	285722	23737	110279822
Drug-induced liver injury	21.30	10.82	432	285308	119635	110183924
Graft versus host disease	21.25	10.82	11	285729	18795	110284764
Hypertensive crisis	21.21	10.82	19	285721	24353	110279206
Ataxia	21.19	10.82	28	285712	30080	110273479
Decreased appetite	21.16	10.82	1464	284276	474382	109829177
Aphasia	20.87	10.82	80	285660	58917	110244642
Dermatitis atopic	20.85	10.82	125	285615	25416	110278143
Cardiomyopathy	20.83	10.82	34	285706	33491	110270068
Hepatomegaly	20.75	10.82	15	285725	21399	110282160
Acute respiratory failure	20.68	10.82	112	285628	75148	110228411
Acute pulmonary oedema	20.65	10.82	9	285731	16987	110286572
Pulmonary toxicity	20.63	10.82	10	285730	17736	110285823
Pulmonary congestion	20.59	10.82	30	285710	30936	110272623
Basal cell carcinoma	20.47	10.82	55	285685	45215	110258344
Obstructive defaecation	20.35	10.82	11	285729	251	110303308
Metastases to bone	20.27	10.82	31	285709	31341	110272218
No adverse event	20.22	10.82	110	285630	73729	110229830
Blood immunoglobulin M increased	20.18	10.82	23	285717	1614	110301945
Generalised oedema	20.16	10.82	30	285710	30674	110272885
Pulmonary hypertension	20.10	10.82	74	285666	55146	110248413
Dyspnoea exertional	20.05	10.82	172	285568	103888	110199671
Product substitution issue	20.04	10.82	18	285722	23043	110280516
Oral candidiasis	19.99	10.82	190	285550	44570	110258989
Vasculitis	19.93	10.82	39	285701	35834	110267725
Mouth ulceration	19.93	10.82	61	285679	48077	110255482
Congestive cardiomyopathy	19.87	10.82	6	285734	14213	110289346
Device malfunction	19.86	10.82	22	285718	25536	110278023
Blood urea increased	19.78	10.82	74	285666	54883	110248676
Tendonitis	19.67	10.82	23	285717	26060	110277499
Partial seizures	19.49	10.82	3	285737	11346	110292213
Bundle branch block right	19.47	10.82	4	285736	12287	110291272
Ankylosing spondylitis	19.40	10.82	8	285732	15604	110287955
Cardiac tamponade	19.39	10.82	3	285737	11304	110292255
Catatonia	19.37	10.82	3	285737	11297	110292262
Granuloma skin	19.33	10.82	3	285737	11280	110292279
Ileus	19.25	10.82	31	285709	30698	110272861
Enteritis	19.12	10.82	13	285727	19143	110284416
Haemodialysis	19.10	10.82	11	285729	17708	110285851
Acidosis	19.09	10.82	18	285722	22513	110281046
Immune thrombocytopenia	19.02	10.82	18	285722	22476	110281083
Lichen sclerosus	18.98	10.82	19	285721	1149	110302410
Jaundice cholestatic	18.95	10.82	7	285733	14601	110288958
Metastases to lung	18.88	10.82	19	285721	23044	110280515
Hypervolaemia	18.86	10.82	65	285675	49395	110254164
Hyperthyroidism	18.82	10.82	29	285711	29232	110274327
Lymphopenia	18.78	10.82	48	285692	40122	110263437
Appendicitis	18.76	10.82	132	285608	28332	110275227
Decreased immune responsiveness	18.68	10.82	61	285679	9545	110294014
Adenovirus infection	18.66	10.82	3	285737	10991	110292568
Bladder cancer	18.66	10.82	15	285725	20277	110283282
Pulseless electrical activity	18.64	10.82	10	285730	16747	110286812
Rash vesicular	18.47	10.82	81	285659	14571	110288988
Gastric haemorrhage	18.45	10.82	9	285731	15906	110287653
Iris hypopigmentation	18.39	10.82	7	285733	67	110303492
Renal injury	18.28	10.82	13	285727	18700	110284859
Stress cardiomyopathy	18.23	10.82	9	285731	15797	110287762
Pneumothorax	18.22	10.82	40	285700	35245	110268314
Organising pneumonia	18.19	10.82	7	285733	14236	110289323
Disease recurrence	18.09	10.82	88	285652	60696	110242863
Endocarditis	18.05	10.82	6	285734	13365	110290194
Dysuria	18.04	10.82	87	285653	60144	110243415
Mucormycosis	17.82	10.82	3	285737	10625	110292934
Oesophageal carcinoma	17.75	10.82	4	285736	11520	110292039
Rebound effect	17.74	10.82	8	285732	14798	110288761
Cyanosis	17.71	10.82	31	285709	29710	110273849
Intestinal ischaemia	17.50	10.82	10	285730	16169	110287390
Seronegative arthritis	17.50	10.82	74	285666	13103	110290456
Atrioventricular block	17.46	10.82	11	285729	16866	110286693
Obstructive airways disorder	17.36	10.82	61	285679	46088	110257471
Cystitis haemorrhagic	17.34	10.82	5	285735	12204	110291355
Renal cancer	17.33	10.82	6	285734	13028	110290531
Caesarean section	17.30	10.82	7	285733	13810	110289749
Encephalitis	17.23	10.82	14	285726	18825	110284734
Coronary artery stenosis	17.17	10.82	7	285733	13751	110289808
Emotional distress	17.06	10.82	59	285681	44788	110258771
Toxic encephalopathy	17.04	10.82	9	285731	15205	110288354
Amnesia	16.99	10.82	374	285366	105034	110198525
Large intestine perforation	16.98	10.82	11	285729	16618	110286941
Blood pressure systolic increased	16.98	10.82	135	285605	82856	110220703
Accidental exposure to product	16.93	10.82	69	285671	49939	110253620
Kidney transplant rejection	16.86	10.82	5	285735	11982	110291577
Skin ulcer	16.78	10.82	96	285644	63549	110240010
Heart rate increased	16.70	10.82	266	285474	143568	110159991
Granulocytopenia	16.65	10.82	6	285734	12709	110290850
Malnutrition	16.64	10.82	28	285712	27251	110276308
Brain injury	16.59	10.82	7	285733	13469	110290090
Personality change	16.58	10.82	4	285736	10998	110292561
Azotaemia	16.57	10.82	3	285737	10082	110293477
Erythema multiforme	16.57	10.82	18	285722	21079	110282480
Corneal erosion	16.50	10.82	12	285728	467	110303092
Skin toxicity	16.41	10.82	5	285735	11778	110291781
Enterocolitis	16.22	10.82	15	285725	18934	110284625
Left atrial volume increased	16.15	10.82	7	285733	96	110303463
Cestode infection	16.11	10.82	10	285730	298	110303261
Ejection fraction decreased	16.08	10.82	53	285687	40827	110262732
Systemic infection	15.97	10.82	3	285737	9816	110293743
Bacteraemia	15.97	10.82	56	285684	42334	110261225
Erysipelas	15.94	10.82	7	285733	13151	110290408
Sputum discoloured	15.86	10.82	30	285710	27915	110275644
Hemiparaesthesia	15.85	10.82	11	285729	397	110303162
Bronchospasm	15.85	10.82	34	285706	30205	110273354
Gastritis	15.83	10.82	78	285662	53621	110249938
Hydronephrosis	15.82	10.82	18	285722	20647	110282912
Device related infection	15.71	10.82	51	285689	39468	110264091
Chest discomfort	15.66	10.82	336	285404	173512	110130047
Cachexia	15.62	10.82	7	285733	12998	110290561
Blood sodium decreased	15.55	10.82	49	285691	38270	110265289
Paranoia	15.55	10.82	21	285719	22353	110281206
Cerebral haematoma	15.54	10.82	3	285737	9629	110293930
Mental disorder	15.46	10.82	50	285690	38741	110264818
Child abuse	15.44	10.82	15	285725	874	110302685
Apnoea	15.38	10.82	8	285732	13631	110289928
Gastrointestinal stoma output abnormal	15.28	10.82	11	285729	421	110303138
Abortion spontaneous	15.24	10.82	42	285698	34240	110269319
Functional gastrointestinal disorder	15.15	10.82	42	285698	6007	110297552
Chronic graft versus host disease	15.14	10.82	3	285737	9454	110294105
Dialysis	15.12	10.82	17	285723	19602	110283957
Spinal fusion surgery	15.06	10.82	55	285685	9101	110294458
Faecaloma	15.04	10.82	10	285730	14898	110288661
Rhinocerebral mucormycosis	14.91	10.82	19	285721	1498	110302061
Cytopenia	14.85	10.82	35	285705	30081	110273478
Hypogammaglobulinaemia	14.82	10.82	18	285722	20058	110283501
Pustular psoriasis	14.78	10.82	72	285668	13533	110290026
Device dislocation	14.73	10.82	38	285702	31666	110271893
Staphylococcal sepsis	14.72	10.82	14	285726	17440	110286119
Blood alkaline phosphatase increased	14.69	10.82	115	285625	70820	110232739
Burning sensation	14.68	10.82	256	285484	68956	110234603
Bradyphrenia	14.59	10.82	6	285734	11722	110291837
Arteriosclerosis	14.58	10.82	26	285714	24741	110278818
Multiple-drug resistance	14.58	10.82	8	285732	13227	110290332
Cushingoid	14.55	10.82	6	285734	11706	110291853
Antinuclear antibody positive	14.49	10.82	3	285737	9165	110294394
Lung hernia	14.49	10.82	6	285734	73	110303486
Pulmonary arterial hypertension	14.40	10.82	40	285700	32528	110271031
Colorectal cancer	14.37	10.82	3	285737	9111	110294448
Arteriospasm coronary	14.34	10.82	3	285737	9097	110294462
Respiratory acidosis	14.32	10.82	9	285731	13817	110289742
Spinal pain	14.32	10.82	16	285724	18499	110285060
Device use error	14.31	10.82	3	285737	9086	110294473
Product use in unapproved indication	14.29	10.82	1342	284398	446035	109857524
Grip strength	14.28	10.82	54	285686	9087	110294472
Nasal cyst	14.26	10.82	5	285735	37	110303522
Restlessness	14.23	10.82	86	285654	56173	110247386
Blood lactic acid increased	14.17	10.82	12	285728	15809	110287750
Hepatocellular carcinoma	14.12	10.82	4	285736	9876	110293683
Normal newborn	14.11	10.82	101	285639	21795	110281764
Herpes simplex	14.07	10.82	12	285728	15752	110287807
Neoplasm malignant	14.04	10.82	49	285691	37094	110266465
Premenstrual syndrome	14.00	10.82	12	285728	594	110302965
Eye injury	13.97	10.82	48	285692	7707	110295852
Blood pressure increased	13.95	10.82	536	285204	257837	110045722
Lung neoplasm malignant	13.92	10.82	43	285697	33799	110269760
Fear of injection	13.91	10.82	3	285737	8908	110294651
Atrioventricular block complete	13.80	10.82	19	285721	20063	110283496
Metabolic disorder	13.70	10.82	5	285735	10505	110293054
Speech disorder	13.61	10.82	98	285642	61471	110242088
Behaviour disorder	13.61	10.82	4	285736	9643	110293916
Autoimmune hepatitis	13.54	10.82	11	285729	14793	110288766
Ventricular hypokinesia	13.53	10.82	6	285734	11208	110292351
Clonus	13.47	10.82	3	285737	8713	110294846
Sleep disorder due to general medical condition, hypersomnia type	13.46	10.82	21	285719	1998	110301561
Hydrocephalus	13.41	10.82	5	285735	10370	110293189
Gastrointestinal toxicity	13.39	10.82	6	285734	11142	110292417
Staphylococcal bacteraemia	13.37	10.82	14	285726	16674	110286885
Nausea	13.33	10.82	2907	282833	1232783	109070776
Vaginal haemorrhage	13.30	10.82	28	285712	25046	110278513
Congenital neuropathy	13.26	10.82	4	285736	17	110303542
Intestinal perforation	13.24	10.82	21	285719	20923	110282636
Ocular pemphigoid	13.23	10.82	8	285732	227	110303332
Irritability	13.21	10.82	71	285669	47738	110255821
Left ventricular hypertrophy	13.20	10.82	9	285731	13235	110290324
Pemphigoid	13.19	10.82	19	285721	19688	110283871
Supraventricular tachycardia	13.18	10.82	27	285713	24395	110279164
Brow ptosis	13.11	10.82	8	285732	231	110303328
Blood immunoglobulin A decreased	13.11	10.82	22	285718	2226	110301333
Inhibitory drug interaction	13.04	10.82	35	285705	4912	110298647
Palmar-plantar erythrodysaesthesia syndrome	13.03	10.82	58	285682	40967	110262592
Haemoglobin decreased	12.99	10.82	518	285222	248209	110055350
Upper gastrointestinal haemorrhage	12.98	10.82	76	285664	50020	110253539
Lymphoma	12.96	10.82	20	285720	20151	110283408
Potentiating drug interaction	12.88	10.82	7	285733	11636	110291923
Injection related reaction	12.81	10.82	18	285722	1560	110301999
Incoherent	12.67	10.82	3	285737	8355	110295204
Oesophageal candidiasis	12.66	10.82	7	285733	11527	110292032
Second primary malignancy	12.51	10.82	17	285723	18051	110285508
Metastasis	12.47	10.82	3	285737	8264	110295295
Tachyarrhythmia	12.46	10.82	3	285737	8258	110295301
Hemiplegia	12.46	10.82	25	285715	22757	110280802
Head injury	12.39	10.82	63	285677	42954	110260605
Laryngeal oedema	12.23	10.82	5	285735	9802	110293757
Fear	12.22	10.82	26	285714	23167	110280392
Atelectasis	12.21	10.82	51	285689	36661	110266898
Anal incontinence	12.10	10.82	24	285716	21940	110281619
Fracture	12.07	10.82	29	285711	24759	110278800
Colitis ischaemic	11.99	10.82	17	285723	17733	110285826
Intentional product misuse	11.99	10.82	438	285302	132466	110171093
Polyuria	11.97	10.82	17	285723	17721	110285838
Hypovolaemic shock	11.95	10.82	12	285728	14571	110288988
Gastric disorder	11.95	10.82	45	285695	33312	110270247
Sarcoidosis	11.95	10.82	9	285731	12570	110290989
Brain herniation	11.92	10.82	4	285736	8859	110294700
Hepatic cancer	11.92	10.82	7	285733	11149	110292410
Lethargy	11.91	10.82	170	285570	93406	110210153
Back pain	11.86	10.82	1113	284627	369883	109933676
Left ventricular dysfunction	11.83	10.82	27	285713	23466	110280093
Cholecystitis acute	11.81	10.82	14	285726	15768	110287791
Pneumonia bacterial	11.80	10.82	32	285708	26229	110277330
Death neonatal	11.76	10.82	18	285722	1685	110301874
Hypotonia	11.75	10.82	14	285726	15731	110287828
Neutrophilia	11.73	10.82	6	285734	10323	110293236
Wrong technique in product usage process	11.72	10.82	157	285583	87191	110216368
Cholangitis	11.69	10.82	15	285725	16320	110287239
Varicose vein	11.68	10.82	42	285698	6898	110296661
Cardiopulmonary failure	11.67	10.82	3	285737	7900	110295659
Hypovolaemia	11.67	10.82	24	285716	21650	110281909
Ileus paralytic	11.67	10.82	8	285732	11729	110291830
Orthopnoea	11.66	10.82	7	285733	11014	110292545
Swelling face	11.65	10.82	168	285572	92153	110211406
Dermatitis bullous	11.63	10.82	17	285723	17512	110286047
Petechiae	11.58	10.82	27	285713	23290	110280269
Granuloma	11.57	10.82	5	285735	9485	110294074
Lip swelling	11.52	10.82	80	285660	50587	110252972
Paralysis	11.50	10.82	14	285726	15586	110287973
Blood uric acid increased	11.48	10.82	95	285645	21434	110282125
Ventricular extrasystoles	11.42	10.82	26	285714	22615	110280944
Product preparation error	11.41	10.82	57	285683	10822	110292737
Drug level above therapeutic	11.38	10.82	8	285732	11580	110291979
Unevaluable event	11.36	10.82	98	285642	59129	110244430
Flank pain	11.31	10.82	27	285713	23103	110280456
Crepitations	11.29	10.82	7	285733	10828	110292731
Hepatitis fulminant	11.28	10.82	4	285736	8556	110295003
Fumbling	11.25	10.82	6	285734	133	110303426
Nasal obstruction	11.25	10.82	26	285714	3324	110300235
Ketoacidosis	11.25	10.82	6	285734	10081	110293478
Balance disorder	11.22	10.82	387	285353	116173	110187386
Stiff person syndrome	11.21	10.82	11	285729	649	110302910
Prothrombin time prolonged	11.20	10.82	17	285723	17244	110286315
Pyelonephritis	11.18	10.82	31	285709	25219	110278340
Guillain-Barre syndrome	11.12	10.82	7	285733	10737	110292822
Odynophagia	11.11	10.82	12	285728	14089	110289470
Anal fistula	11.09	10.82	4	285736	8469	110295090
Cardiac failure acute	11.08	10.82	29	285711	24049	110279510
Pain in jaw	11.05	10.82	82	285658	51095	110252464
Necrosis	11.04	10.82	8	285732	11398	110292161
Duodenal ulcer	11.03	10.82	21	285719	19493	110284066
Depressed level of consciousness	11.00	10.82	214	285526	112064	110191495
Necrotising fasciitis	10.98	10.82	3	285737	7588	110295971
Muscle twitching	10.97	10.82	40	285700	29895	110273664
Duodenitis	10.97	10.82	5	285735	9191	110294368
Premature labour	10.92	10.82	5	285735	9167	110294392
Urinary incontinence	10.91	10.82	77	285663	48510	110255049

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anaphylactic shock	23.32	19.04	3	3	9	113938

Pharmacologic Action:

Source	Code	Description
ATC	D03AX05	DERMATOLOGICALS PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS CICATRIZANTS Other cicatrizants
ATC	M09AX01	MUSCULO-SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM Other drugs for disorders of the musculo-skeletal system
ATC	R01AX09	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Other nasal preparations
ATC	S01KA01	SENSORY ORGANS OPHTHALMOLOGICALS SURGICAL AIDS Viscoelastic substances
ATC	S01KA51	SENSORY ORGANS OPHTHALMOLOGICALS SURGICAL AIDS Viscoelastic substances
MeSH PA	D000276	Adjuvants, Immunologic
MeSH PA	D007155	Immunologic Factors
MeSH PA	D020011	Protective Agents
MeSH PA	D055675	Viscosupplements
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:73336	vulnerary
CHEBI has role	CHEBI:77746	human metabolite
CHEBI has role	CHEBI:233423	antifibrotic agent
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:49201	anti-ulcer drug
CHEBI has role	CHEBI:77715	nasal decongestant

Related Drugs by ATC class:

D03AX Other cicatrizants 9 drugs

becaplerminberemagene geperpaveccalcium pantothenatecrilanomerdexpanthenolenoxolonesodium chloritetrafermintrolamine

M09AX Other drugs for disorders of the musculo-skeletal system 11 drugs

aceneuramic acidatalurencasimerseneteplirsengivinostatgolodirsennusinersenonasemnogene abeparvovecpalovarotenerisdiplamviltolarsen

R01AX Other nasal preparations 6 drugs

framycetinhexamidineipratropiummupirocinretinolritiometan

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Surgical procedure on eye proper	indication	373353005
Operation on lens	indication	386612009
Glaucoma	contraindication	23986001	DOID:1686

🐶 Veterinary Drug Use

Species	Use	Relation
Horses	Joint dysfunction caused by noninfectious synovitis associated with osteoarthritis	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Hylartin V, Hylartin V Injection	Zoetis Inc.	1
Hyvisc	Anika Therapeutics	1
Equron	Zoetis Inc.	1
Synacid	Intervet Inc.	1
Hyalovet	Boehringer lngelheim Animal Health USA Inc.	1
Legend Injectable Solution, Legend Multi Dose	Boehringer lngelheim Animal Health USA Inc.	1
NexHA	Vetoquinol USA Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019426	VUID
N0000147557	NUI
D08043	KEGG_DRUG
9067-32-7	SECONDARY_CAS_RN
4019426	VANDF
4020205	VANDF
C0020196	UMLSCUI
CHEBI:16336	CHEBI
CHEMBL5314376	ChEMBL_ID
CHEMBL4594244	ChEMBL_ID
D006820	MESH_DESCRIPTOR_UI
DB08818	DRUGBANK_ID
S270N0TRQY	UNII
42892	RXNORM
119505	MMSL
18314	MMSL
26653	MMSL
5484	MMSL
d04329	MMSL
d05234	MMSL
002239	NDDF
006663	NDDF
015689	NDDF
38218009	SNOMEDCT_US
387578003	SNOMEDCT_US
96278006	SNOMEDCT_US
S270N0TRQY	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ginsamin Beauty	HUMAN OTC DRUG LABEL	4	44738-6001	GRANULE	60 mg	ORAL	unapproved drug other	3 sections
Cotta	HUMAN OTC DRUG LABEL	3	58748-001	FILM, EXTENDED RELEASE	0.30 g	TOPICAL	unapproved drug other	8 sections
WELLAGE FAMILY MASK SMALL	HUMAN OTC DRUG LABEL	1	69346-0001	PATCH	0.06 g	TOPICAL	unapproved drug other	7 sections
WELLAGE FAMILY MASK LARGE	HUMAN OTC DRUG LABEL	1	69346-0008	PATCH	0.06 g	TOPICAL	unapproved drug other	7 sections
WELLAGE Hyaluronic Acid Micro Needle	HUMAN OTC DRUG LABEL	1	69346-9001	PATCH	99 g	TOPICAL	unapproved drug other	8 sections
Clapiel Hyalon Serum	HUMAN OTC DRUG LABEL	2	69977-020	CREAM	10.50 mg	TOPICAL	unapproved drug other	8 sections
Hyaluronic Acid Micro	HUMAN OTC DRUG LABEL	1	70018-010	PATCH	1.14 g	TOPICAL	unapproved drug other	8 sections
Ramosu Hyaluronic Acid Solution 100	HUMAN OTC DRUG LABEL	1	70465-0003	LIQUID	100 g	TOPICAL	unapproved drug other	6 sections
Im Fill	HUMAN OTC DRUG LABEL	1	70514-0009	PATCH	99.97 g	TOPICAL	unapproved drug other	7 sections
Hyaluronic Acid Gel	HUMAN OTC DRUG LABEL	1	70663-001	GEL	3.50 mg	TOPICAL	unapproved drug other	12 sections
Hyaluronic Acid Gel	HUMAN OTC DRUG LABEL	1	70663-005	GEL	3.50 mg	TOPICAL	unapproved drug other	12 sections
XR CELLULAR MAGIC	HUMAN OTC DRUG LABEL	1	70663-008	GEL	0.10 mg	TOPICAL	unapproved drug other	10 sections
DEEPAIR MICRO INTENSIVE MAGIC	HUMAN OTC DRUG LABEL	1	70961-0001	PATCH	6.10 g	TOPICAL	unapproved drug other	7 sections
PRO PH Filler	HUMAN OTC DRUG LABEL	1	71066-0002	GEL	1000 g	TOPICAL	unapproved drug other	5 sections
KAEWOON FOR MEN	HUMAN OTC DRUG LABEL	2	71237-003	GEL	20 mg	TOPICAL	unapproved drug other	8 sections
KAEWOON FOR WOMEN	HUMAN OTC DRUG LABEL	2	71237-004	GEL	20 mg	TOPICAL	unapproved drug other	8 sections
HYALURON 3S SERUM	HUMAN OTC DRUG LABEL	1	71276-140	CREAM	0.15 g	TOPICAL	unapproved drug other	8 sections
Le-Blen EGF Serum	HUMAN OTC DRUG LABEL	2	72271-100	LOTION	0.40 g	TOPICAL	unapproved drug other	7 sections
Le-Blen FGF Serum	HUMAN OTC DRUG LABEL	3	72271-101	EMULSION	0.40 g	TOPICAL	unapproved drug other	8 sections
Le-Blen Nano Collagen Peptide Serum	HUMAN OTC DRUG LABEL	3	72271-102	LOTION	0.54 g	TOPICAL	unapproved drug other	8 sections
Le-Blen Vitamin C Serum	HUMAN OTC DRUG LABEL	2	72271-103	LOTION	2.84 g	TOPICAL	unapproved drug other	8 sections
Miracle Aqua Peeling	HUMAN OTC DRUG LABEL	1	72557-001	GEL	0.01 g	TOPICAL	unapproved drug other	8 sections
Miracle Laser Mask	HUMAN OTC DRUG LABEL	1	72557-005	CREAM	0.00 g	TOPICAL	unapproved drug other	8 sections
DR.PLINUS FILLINCELL MULTI	HUMAN OTC DRUG LABEL	3	72630-020	PATCH	0.21 g	TOPICAL	unapproved drug other	10 sections
ELCOSYS	HUMAN OTC DRUG LABEL	1	72910-0001	PATCH	99.97 mg	TOPICAL	unapproved drug other	7 sections
PokePoke Patch	HUMAN OTC DRUG LABEL	1	72910-0002	PATCH	94.39 mg	TOPICAL	unapproved drug other	7 sections
FUNEES	HUMAN OTC DRUG LABEL	1	72910-0003	PATCH	6.14 g	TOPICAL	unapproved drug other	7 sections
ASCORBYL PALMITATE 2% / HYALURONIC ACID SODIUM SALT 0.2% / NIACINAMIDE 5% / TRETINOIN 0.025%	HUMAN PRESCRIPTION DRUG LABEL	3	72934-1088	GEL	0.20 g	TOPICAL	unapproved drug other	4 sections
CALCIPOTRIENE 0.005% / DICLOFENAC SODIUM 3% / HYALURONIC ACID SODIUM SALT 2% / NIACINAMIDE 2%	HUMAN PRESCRIPTION DRUG LABEL	4	72934-2030	CREAM	2 g	TOPICAL	unapproved drug other	3 sections
FLUOCINONIDE 0.05% / HYALURONIC ACID SODIUM SALT 0.5% / NIACINAMIDE 4%	HUMAN PRESCRIPTION DRUG LABEL	2	72934-2086	CREAM	0.50 g	TOPICAL	unapproved drug other	4 sections