chlorquinaldol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 3095 72-80-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chlorquinaldol
  • chloquinan
  • chlorchinaldin
  • chlorchinaldol
  • chlorguinaldon
Local anti-infective agent used for skin, gastrointestinal, and vaginal infections with fungi, protozoa, and certain bacteria. In animals, it causes central nervous system damage and is not administered parenterally. It is also used as antiseptic, fungistat, or deodorant.
  • Molecular weight: 228.07
  • Formula: C10H7Cl2NO
  • CLOGP: 3.84
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 33.12
  • ALOGS: -3.63
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.20 g V

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,GSK3B,IKBKB,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 46
kinase-selectivity-class ACVR2B,AXL,BRAF,EIF2AK3,EPHB4,GRK2,MAP2K6,MAPK7,PDK4,PIK3CD,SIK2,TEK,TGFBR1 13
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AH02 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quinoline derivatives
ATC G01AC03 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Quinoline derivatives
ATC P01AA04 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
Hydroxyquinoline derivatives
ATC R02AA11 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
FDA CS M0000728 Allergens
MeSH PA D000890 Anti-Infective Agents
FDA PE N0000175629 Increased Histamine Release
FDA PE N0000184306 Cell-mediated Immunity
FDA EPC N0000185508 Standardized Chemical Allergen
CHEBI has role CHEBI:35820 antiprotozoal drug
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:48218 antiseptic drug
CHEBI has role CHEBI:171664 antiamoebic agent

Related Drugs by ATC class:

D08AH Quinoline derivatives 3 drugs
clioquinoldequaliniumoxyquinoline
G01AC Quinoline derivatives 5 drugs
broxyquinolineclioquinoldequaliniumdiiodohydroxyquinolineoxyquinoline
P01AA Hydroxyquinoline derivatives 4 drugs
broxyquinolineclioquinoltilbroquinoltiliquinol
R02AA Antiseptics 15 drugs
ambazonebenzalkoniumbenzethoniumcetrimoniumcetylpyridiniumchlorhexidinedequaliniumdichlorobenzyl alcoholeuflavinehexamidinehexylresorcinoloctenidine show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 acidic
pKa2 3.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Botulinum neurotoxin type A Enzyme IC50 5 CHEMBL

External reference:

IDSource
N0000166918 NUI
D07208 KEGG_DRUG
C0008292 UMLSCUI
CHEBI:74500 CHEBI
CHEMBL224325 ChEMBL_ID
DB13306 DRUGBANK_ID
D002750 MESH_DESCRIPTOR_UI
6301 PUBCHEM_CID
215 INN_ID
D6VHC87LLS UNII
2407 RXNORM
002899 NDDF
255863008 SNOMEDCT_US
411197006 SNOMEDCT_US

Pharmaceutical products:

None