All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

benzalkonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
quaternary ammonium compounds	3017	139-07-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzalkonium chloride benzalkonium benzyldodecyldimethylammonium chloride benzododecinium	A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics. Molecular weight: 304.54 Formula: C21H38N CLOGP: 3.18 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: ALOGS: -7.85 ROTB: 13

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70	55
kinase-selectivity-class	AKT2,AKT3,AXL,CDK4,EIF2AK3,EPHB4,GRK2,MAP2K6,MTOR,PDK4,PLK1,PRKCD,SIK2,STK33,TEK	15
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	5189.82	9.17	2851	111579	142207	90371810
Toxicity to various agents	3335.49	9.17	2814	111616	285032	90228985
Drug abuse	1881.30	9.17	1215	113215	81132	90432885
Cardio-respiratory arrest	1119.91	9.17	797	113633	62343	90451674
Local anaesthetic systemic toxicity	1025.29	9.17	313	114117	3187	90510830
Intentional overdose	702.95	9.17	722	113708	93112	90420905
Cardiac arrest	651.52	9.17	731	113699	104204	90409813
Overdose	514.64	9.17	801	113629	156908	90357109
Alcohol interaction	493.09	9.17	152	114278	1602	90512415
Suspected suicide	468.84	9.17	233	114197	9335	90504682
Suicide attempt	457.17	9.17	519	113911	74880	90439137
Exposure to toxic agent	375.58	9.17	189	114241	7778	90506239
Maternal exposure during delivery	362.66	9.17	148	114282	3698	90510319
Pemphigus	323.97	9.17	23	114407	326841	90187176
Respiratory arrest	310.33	9.17	289	114141	33022	90480995
Methaemoglobinaemia	309.94	9.17	134	114296	3881	90510136
Victim of crime	307.46	9.17	90	114340	782	90513235
Alcohol poisoning	301.15	9.17	107	114323	1805	90512212
Synovitis	297.82	9.17	34	114396	329718	90184299
Glossodynia	291.05	9.17	33	114397	321746	90192271
Hand deformity	284.81	9.17	24	114406	296338	90217679
Systemic lupus erythematosus	282.00	9.17	57	114373	361839	90152178
Death	263.92	9.17	1208	113222	455343	90058674
Anaphylactic shock	239.63	9.17	245	114185	31372	90482645
Pericarditis	238.60	9.17	30	114400	270121	90243896
Hepatic enzyme increased	231.78	9.17	83	114347	360653	90153364
Wound	221.35	9.17	55	114375	302925	90211092
Toxic anterior segment syndrome	220.44	9.17	89	114341	2161	90511856
Anti-cyclic citrullinated peptide antibody positive	216.90	9.17	23	114407	236410	90277607
Intentional product misuse	213.60	9.17	396	114034	89208	90424809
Substance use disorder	205.15	9.17	82	114348	1938	90512079
Alopecia	203.75	9.17	195	114235	494876	90019141
Duodenal ulcer perforation	199.26	9.17	23	114407	221265	90292752
Anaphylactic reaction	197.68	9.17	378	114052	87146	90426871
Generalised tonic-clonic seizure	194.25	9.17	230	114200	34673	90479344
Hypotension	188.50	9.17	862	113568	324535	90189482
Abdominal discomfort	187.25	9.17	196	114234	477132	90036885
Coma	181.96	9.17	328	114102	72304	90441713
Helicobacter infection	180.25	9.17	34	114396	226816	90287201
Joint swelling	178.65	9.17	224	114206	503076	90010941
Seizure	174.63	9.17	505	113925	152124	90361893
Drug use disorder	172.86	9.17	116	114314	8227	90505790
Rheumatoid factor positive	170.19	9.17	12	114418	171638	90342379
Mydriasis	165.00	9.17	143	114287	14869	90499148
Somnolence	164.57	9.17	609	113821	208475	90305542
Kounis syndrome	164.27	9.17	75	114355	2478	90511539
Folliculitis	163.69	9.17	30	114400	204323	90309694
Psoriatic arthropathy	161.85	9.17	44	114386	228291	90285726
General physical health deterioration	160.37	9.17	128	114302	354987	90159030
Contraindicated product administered	156.72	9.17	106	114324	320033	90193984
Alcohol use	154.83	9.17	64	114366	1653	90512364
Impaired healing	148.45	9.17	55	114375	234144	90279873
Poisoning deliberate	145.81	9.17	139	114291	16347	90497670
Muscle injury	145.72	9.17	24	114406	176630	90337387
Alcohol abuse	144.42	9.17	64	114366	1969	90512048
Rheumatic fever	142.72	9.17	14	114416	153107	90360910
Swelling	136.97	9.17	198	114232	418860	90095157
Chemical submission	132.53	9.17	42	114388	488	90513529
Mobility decreased	132.40	9.17	76	114354	250658	90263359
Agitation	131.32	9.17	273	114157	66825	90447192
Infusion site pain	128.34	9.17	141	114289	19597	90494420
Stress cardiomyopathy	124.61	9.17	116	114314	13239	90500778
Arthropathy	121.68	9.17	171	114259	366071	90147946
Drug intolerance	120.92	9.17	239	114191	447352	90066665
Gastrointestinal toxicity	120.17	9.17	98	114332	9369	90504648
Type 2 diabetes mellitus	118.64	9.17	54	114376	203190	90310827
Anaesthetic complication	117.71	9.17	59	114371	2406	90511611
Pulseless electrical activity	116.63	9.17	94	114336	8838	90505179
Sleep disorder due to general medical condition, insomnia type	114.27	9.17	14	114416	128680	90385337
Irritable bowel syndrome	110.77	9.17	62	114368	207386	90306631
Lower respiratory tract infection	109.81	9.17	93	114337	250566	90263451
Ill-defined disorder	109.68	9.17	48	114382	184843	90329174
Substance abuse	109.21	9.17	74	114356	5332	90508685
Infusion related reaction	107.09	9.17	229	114201	416551	90097466
Ventricular tachycardia	105.97	9.17	143	114287	24565	90489452
Hypersensitivity	105.43	9.17	264	114166	454413	90059604
Therapeutic product effect decreased	105.35	9.17	117	114313	277454	90236563
Poisoning	104.70	9.17	112	114318	15105	90498912
Blister	104.09	9.17	101	114329	254897	90259120
Infusion site swelling	102.10	9.17	98	114332	11622	90502395
Unresponsive to stimuli	101.69	9.17	177	114253	37944	90476073
Loss of consciousness	100.82	9.17	397	114033	139841	90374176
Tachycardia	100.45	9.17	430	114000	157243	90356774
Stomatitis	95.51	9.17	124	114306	274574	90239443
Swollen joint count increased	94.20	9.17	14	114416	111192	90402825
Pulmonary toxicity	92.19	9.17	92	114338	11439	90502578
Bradycardia	89.71	9.17	271	114159	83576	90430441
Rheumatoid arthritis	89.21	9.17	204	114226	362410	90151607
Insurance issue	88.67	9.17	88	114342	10870	90503147
Procedural hypotension	87.48	9.17	42	114388	1558	90512459
Sulphaemoglobinaemia	84.59	9.17	30	114400	503	90513514
Rash	84.31	9.17	624	113806	795476	89718541
Infusion site erythema	82.61	9.17	94	114336	13576	90500441
Lip dry	82.60	9.17	14	114416	100941	90413076
Drug interaction	82.13	9.17	614	113816	275839	90238178
Anaesthetic complication neurological	81.97	9.17	32	114398	709	90513308
Infusion site extravasation	81.83	9.17	82	114348	10246	90503771
Body tinea	81.32	9.17	44	114386	2104	90511913
Victim of sexual abuse	80.39	9.17	31	114399	664	90513353
Infusion site pruritus	79.56	9.17	67	114363	6698	90507319
Gait inability	77.83	9.17	44	114386	146412	90367605
Peripheral venous disease	77.33	9.17	8	114422	83913	90430104
Apnoea	76.91	9.17	76	114354	9338	90504679
Facet joint syndrome	75.49	9.17	16	114414	98373	90415644
Respiratory depression	74.32	9.17	95	114335	15480	90498537
Diarrhoea	74.03	9.17	794	113636	938396	89575621
Discomfort	73.56	9.17	147	114283	274188	90239829
Pulse absent	73.34	9.17	61	114369	5994	90508023
Electrocardiogram QRS complex prolonged	72.79	9.17	66	114364	7282	90506735
Sinus tachycardia	71.68	9.17	129	114301	28384	90485633
Blood alcohol increased	71.64	9.17	27	114403	542	90513475
Blood cholesterol increased	71.16	9.17	95	114335	207917	90306100
Arthralgia	69.73	9.17	638	113792	777884	89736133
Ventricular fibrillation	69.13	9.17	87	114343	13957	90500060
Abdominal pain upper	68.91	9.17	204	114226	332470	90181547
Mental status changes	68.55	9.17	165	114265	44514	90469503
Infusion site haemorrhage	66.56	9.17	55	114375	5356	90508661
Osteoarthritis	66.33	9.17	90	114340	195640	90318377
Product administration interrupted	65.69	9.17	80	114350	12412	90501605
Drug dependence	65.36	9.17	126	114304	29201	90484816
Fibromyalgia	64.83	9.17	100	114330	206169	90307848
Sleep disorder	64.18	9.17	94	114336	197936	90316081
Inhibitory drug interaction	63.19	9.17	43	114387	3120	90510897
Postmortem blood drug level abnormal	63.14	9.17	20	114410	232	90513785
Alcoholism	62.98	9.17	35	114395	1765	90512252
Nystagmus	62.14	9.17	60	114370	7167	90506850
Neoplasm malignant	60.68	9.17	133	114297	33747	90480270
Depressed level of consciousness	60.56	9.17	216	114214	72568	90441449
Phrenic nerve paralysis	60.53	9.17	21	114409	329	90513688
Prescribed underdose	60.07	9.17	11	114419	75008	90439009
Grip strength decreased	58.18	9.17	22	114408	92554	90421463
Victim of chemical submission	58.14	9.17	25	114405	714	90513303
Embolia cutis medicamentosa	58.09	9.17	24	114406	619	90513398
Inflammation	57.65	9.17	85	114345	178507	90335510
Pulmonary fibrosis	57.54	9.17	32	114398	107471	90406546
Systemic toxicity	57.32	9.17	19	114411	257	90513760
Tracheal deviation	57.32	9.17	19	114411	257	90513760
Obesity	57.06	9.17	31	114399	105476	90408541
Infusion site bruising	57.06	9.17	46	114384	4326	90509691
Infection susceptibility increased	57.03	9.17	44	114386	3882	90510135
Peripheral swelling	57.00	9.17	298	114132	412808	90101209
Asthenia	56.56	9.17	418	114012	533333	89980684
Electrocardiogram ST segment elevation	56.15	9.17	44	114386	3972	90510045
C-reactive protein increased	55.99	9.17	89	114341	181300	90332717
Corneal oedema	55.90	9.17	33	114397	1868	90512149
Cardiogenic shock	55.60	9.17	106	114324	24362	90489655
Withdrawal syndrome	55.46	9.17	101	114329	22423	90491594
Wheezing	55.28	9.17	138	114292	237942	90276075
Sinusitis	53.45	9.17	665	113765	342423	90171594
Breast cancer stage III	53.19	9.17	20	114410	84427	90429590
Joint injury	52.68	9.17	123	114307	32541	90481476
Wound infection	52.31	9.17	35	114395	106367	90407650
Suicidal ideation	52.18	9.17	208	114222	73647	90440370
Status epilepticus	52.12	9.17	89	114341	18785	90495232
Deep vein thrombosis postoperative	51.36	9.17	13	114417	70796	90443221
Night sweats	51.36	9.17	52	114378	128714	90385303
Extradural haematoma	50.81	9.17	32	114398	2036	90511981
Product use issue	50.70	9.17	229	114201	329690	90184327
Aggression	50.41	9.17	107	114323	26561	90487456
Electrocardiogram QT prolonged	50.34	9.17	203	114227	72253	90441764
Illness	50.21	9.17	221	114209	81748	90432269
Extradural abscess	50.17	9.17	27	114403	1277	90512740
Incorrect drug administration rate	49.95	9.17	46	114384	5177	90508840
Gastrointestinal disorder	49.88	9.17	162	114268	256525	90257492
Circulatory collapse	49.50	9.17	102	114328	24802	90489215
Incorrect route of product administration	48.94	9.17	158	114272	50468	90463549
Glucose tolerance impaired	48.40	9.17	55	114375	7930	90506087
Joint range of motion decreased	48.39	9.17	60	114370	135583	90378434
Weight increased	48.32	9.17	319	114111	417608	90096409
Bursitis	48.27	9.17	57	114373	131597	90382420
Dislocation of vertebra	47.50	9.17	7	114423	55961	90458056
Hypercholesterolaemia	47.21	9.17	35	114395	100857	90413160
Dermatitis contact	46.98	9.17	71	114359	13524	90500493
Lung disorder	46.77	9.17	73	114357	149810	90364207
Fear	45.40	9.17	78	114352	16544	90497473
Hepatotoxicity	45.16	9.17	144	114286	45698	90468319
Drug withdrawal syndrome	45.06	9.17	107	114323	28616	90485401
Vascular malformation	44.98	9.17	21	114409	731	90513286
Musculoskeletal stiffness	44.86	9.17	207	114223	296325	90217692
Product adhesion issue	44.79	9.17	43	114387	5099	90508918
COVID-19	44.56	9.17	365	114065	168478	90345539
Knee arthroplasty	44.17	9.17	25	114405	83157	90430860
Foetal exposure during delivery	44.13	9.17	17	114413	363	90513654
Red blood cell sedimentation rate increased	43.61	9.17	25	114405	82570	90431447
Paranasal cyst	43.49	9.17	21	114409	789	90513228
Infusion site urticaria	43.30	9.17	27	114403	1688	90512329
Hip arthroplasty	43.28	9.17	21	114409	76187	90437830
Therapy interrupted	42.79	9.17	150	114280	49958	90464059
X-ray abnormal	42.71	9.17	4	114426	45420	90468597
Hypoxia	42.69	9.17	193	114237	72206	90441811
Purtscher retinopathy	42.17	9.17	13	114417	137	90513880
Seasonal allergy	42.04	9.17	91	114339	22892	90491125
Pulmonary oedema	41.59	9.17	172	114258	61908	90452109
Thrombocytopenia	41.05	9.17	131	114299	208594	90305423
Poor quality sleep	40.93	9.17	94	114336	24599	90489418
Prescribed overdose	40.58	9.17	38	114392	97587	90416430
Areflexia	40.55	9.17	35	114395	3618	90510399
Drug level increased	39.90	9.17	100	114330	27662	90486355
Psoriasis	39.73	9.17	79	114351	147675	90366342
Brain stem syndrome	39.57	9.17	19	114411	705	90513312
Nail disorder	38.89	9.17	13	114417	59054	90454963
Liver injury	38.71	9.17	100	114330	170467	90343550
Blepharospasm	38.66	9.17	11	114419	55434	90458583
Onychomadesis	38.47	9.17	6	114424	45992	90468025
Liver disorder	37.89	9.17	59	114371	121210	90392807
Cyanosis	37.86	9.17	79	114351	19376	90494641
Emotional distress	37.80	9.17	117	114313	36545	90477472
Pain	37.78	9.17	964	113466	995377	89518640
Treatment failure	37.67	9.17	227	114203	303701	90210316
Condition aggravated	37.48	9.17	528	113902	595017	89919000
Dry mouth	37.26	9.17	114	114316	183945	90330072
Lagophthalmos	37.24	9.17	16	114414	456	90513561
Meningitis chemical	37.24	9.17	14	114416	279	90513738
Staphylococcal infection	37.13	9.17	140	114290	48299	90465718
Bronchospasm	36.75	9.17	81	114349	20628	90493389
Asphyxia	36.56	9.17	45	114385	7058	90506959
Anterior chamber cell	36.28	9.17	18	114412	718	90513299
Peripheral nerve injury	36.21	9.17	18	114412	721	90513296
Encephalopathy	35.40	9.17	134	114296	46310	90467707
Disease progression	35.40	9.17	92	114338	156523	90357494
Underdose	35.37	9.17	12	114418	54005	90460012
Pruritus	34.82	9.17	478	113952	541047	89972970
Neurotoxicity	34.79	9.17	81	114349	21386	90492631
Pneumocephalus	34.72	9.17	13	114417	256	90513761
Loss of personal independence in daily activities	34.71	9.17	75	114355	136030	90377987
Bundle branch block left	34.36	9.17	46	114384	7839	90506178
Bone erosion	34.33	9.17	12	114418	53009	90461008
Myocarditis	34.11	9.17	62	114368	13744	90500273
Restlessness	34.09	9.17	111	114319	35609	90478408
Adverse event	34.01	9.17	60	114370	117358	90396659
Neutropenia	34.00	9.17	157	114273	224747	90289270
Hypoaesthesia	33.74	9.17	245	114185	313965	90200052
Shock	33.62	9.17	96	114334	28682	90485335
Spinal epidural haemorrhage	33.30	9.17	13	114417	288	90513729
Administration site pain	33.29	9.17	20	114410	1169	90512848
Cauda equina syndrome	33.20	9.17	21	114409	1346	90512671
Type I hypersensitivity	32.94	9.17	33	114397	4122	90509895
Infusion site mass	32.82	9.17	25	114405	2164	90511853
Hypopyon	32.60	9.17	18	114412	896	90513121
Infusion site discharge	32.59	9.17	26	114404	2409	90511608
Amnesia	32.17	9.17	241	114189	108264	90405753
Removal of foreign body	31.73	9.17	7	114423	15	90514002
Hepatic encephalopathy	31.71	9.17	60	114370	13712	90500305
Fatigue	31.39	9.17	1167	113263	1152856	89361161
Endophthalmitis	31.38	9.17	34	114396	4651	90509366
Bursitis infective	31.29	9.17	21	114409	1489	90512528
Spinal epidural haematoma	31.17	9.17	20	114410	1314	90512703
Dyspepsia	30.75	9.17	137	114293	198023	90315994
Miosis	30.62	9.17	48	114382	9436	90504581
Paraplegia	30.61	9.17	29	114401	3383	90510634
Dysarthria	30.46	9.17	143	114287	54339	90459678
Nasopharyngitis	30.40	9.17	348	114082	406756	90107261
Respiratory tract infection	30.11	9.17	151	114279	58927	90455090
Confusional state	30.08	9.17	327	114103	385878	90128139
Decreased appetite	30.05	9.17	317	114113	376223	90137794
Infusion site rash	30.04	9.17	25	114405	2458	90511559
Accidental death	29.85	9.17	23	114407	2025	90511992
Mastoiditis	29.38	9.17	21	114409	1649	90512368
Stridor	29.03	9.17	33	114397	4760	90509257
Fear of eating	28.77	9.17	13	114417	419	90513598
Protein C increased	28.36	9.17	8	114422	60	90513957
Colitis ulcerative	28.07	9.17	21	114409	60245	90453772
Blood ethanol increased	27.99	9.17	9	114421	110	90513907
Postmortem blood drug level	27.99	9.17	9	114421	110	90513907
Gastrooesophageal reflux disease	27.65	9.17	112	114318	166225	90347792
Drug ineffective for unapproved indication	27.64	9.17	161	114269	66483	90447534
Frequent bowel movements	27.62	9.17	19	114411	56916	90457101
Platelet aggregation inhibition	27.59	9.17	10	114420	179	90513838
Respiratory acidosis	27.49	9.17	42	114388	8077	90505940
Disinhibition	27.43	9.17	17	114413	1051	90512966
Corneal epithelium defect	27.18	9.17	13	114417	478	90513539
Haemodynamic instability	26.85	9.17	51	114379	11688	90502329
Liver function test increased	26.78	9.17	41	114389	84814	90429203
Hyperthermia malignant	26.77	9.17	18	114412	1280	90512737
Somnambulism	26.63	9.17	36	114394	6192	90507825
Drug ineffective	26.41	9.17	1455	112975	1382843	89131174
Lupus vulgaris	26.23	9.17	12	114418	45047	90468970
Accidental overdose	26.21	9.17	87	114343	28186	90485831
Ventricular hypokinesia	26.15	9.17	33	114397	5308	90508709
Retinitis	26.14	9.17	8	114422	38450	90475567
Epidural haemorrhage	25.95	9.17	11	114419	303	90513714
Anal skin tags	25.94	9.17	14	114416	666	90513351
Parophthalmia	25.88	9.17	12	114418	411	90513606
Neonatal toxicity	25.75	9.17	7	114423	45	90513972
Congestive hepatopathy	25.74	9.17	25	114405	3008	90511009
Altered state of consciousness	25.73	9.17	93	114337	31439	90482578
Anxiety	25.72	9.17	541	113889	309231	90204786
Premature delivery	25.65	9.17	107	114323	38655	90475362
Vitritis	25.46	9.17	19	114411	1595	90512422
Urinary tract infection	25.45	9.17	534	113896	305098	90208919
Hyperlipidaemia	25.38	9.17	75	114355	22841	90491176
Anhedonia	25.33	9.17	49	114381	11382	90502635
Renal injury	25.31	9.17	46	114384	10197	90503820
Impaired work ability	25.08	9.17	67	114363	19259	90494758
Upper respiratory tract infection	25.03	9.17	260	114170	128058	90385959
Schizencephaly	25.02	9.17	11	114419	332	90513685
Cerebral haemorrhage foetal	24.86	9.17	11	114419	337	90513680
Back injury	24.77	9.17	14	114416	46608	90467409
Off label use	24.76	9.17	1139	113291	1101113	89412904
Breast cancer stage II	24.66	9.17	7	114423	35327	90478690
Vocal cord dysfunction	24.63	9.17	15	114415	899	90513118
Bone density decreased	24.43	9.17	62	114368	17283	90496734
Infusion site nodule	24.35	9.17	19	114411	1704	90512313
Brain oedema	24.33	9.17	62	114368	17323	90496694
Therapy partial responder	24.28	9.17	72	114358	21971	90492046
C-reactive protein	24.26	9.17	5	114425	31362	90482655
Metabolic acidosis	24.07	9.17	136	114294	55540	90458477
Substance dependence	23.96	9.17	9	114421	179	90513838
Drug hypersensitivity	23.78	9.17	427	114003	463182	90050835
Surgery	23.78	9.17	116	114314	44771	90469246
Blood lactic acid increased	23.72	9.17	41	114389	8737	90505280
Otitis media	23.70	9.17	33	114397	5837	90508180
Aqueous fibrin	23.69	9.17	8	114422	115	90513902
Arthritis	23.42	9.17	120	114310	167195	90346822
Central pain syndrome	23.37	9.17	13	114417	657	90513360
Brain death	23.20	9.17	27	114403	3994	90510023
Impaired quality of life	23.06	9.17	73	114357	23071	90490946
Malaise	22.93	9.17	564	113866	585422	89928595
Coeliac disease	22.84	9.17	14	114416	44596	90469421
Trigeminal palsy	22.60	9.17	7	114423	75	90513942
Homicide	22.52	9.17	10	114420	309	90513708
Kidney infection	22.49	9.17	78	114352	25838	90488179
Drug reaction with eosinophilia and systemic symptoms	22.49	9.17	13	114417	42745	90471272
Septic arthritis staphylococcal	22.35	9.17	12	114418	565	90513452
Medical device site cellulitis	22.35	9.17	9	114421	217	90513800
Administration site swelling	22.21	9.17	17	114413	1482	90512535
Cardiac death	22.14	9.17	12	114418	576	90513441
Ophthalmoplegia	21.98	9.17	18	114412	1731	90512286
Spinal anaesthesia	21.96	9.17	7	114423	83	90513934
Alcohol withdrawal syndrome	21.96	9.17	14	114416	910	90513107
Sciatica	21.81	9.17	61	114369	101321	90412696
Retinal vasculitis	21.80	9.17	17	114413	1524	90512493
Eyelid ptosis	21.69	9.17	40	114390	8966	90505051
Haematochezia	21.67	9.17	35	114395	70878	90443139
Urticaria	21.55	9.17	272	114158	312462	90201555
Lower limb fracture	21.54	9.17	47	114383	84966	90429051
Meningitis aseptic	21.48	9.17	34	114396	6739	90507278
Infusion site discomfort	21.38	9.17	18	114412	1798	90512219
Drug screen positive	21.30	9.17	25	114405	3732	90510285
Alcoholic	21.22	9.17	5	114425	16	90514001
Unevaluable event	21.14	9.17	130	114300	54718	90459299
Epidural analgesia	21.12	9.17	8	114422	163	90513854
Malignant neoplasm progression	21.05	9.17	67	114363	106803	90407214
Gait disturbance	20.89	9.17	219	114211	260277	90253740
Procedure aborted	20.89	9.17	8	114422	168	90513849
Serotonin syndrome	20.85	9.17	99	114331	37788	90476229
Upper airway obstruction	20.55	9.17	14	114416	1018	90512999
Electrocardiogram ST segment depression	20.44	9.17	23	114407	3280	90510737
Spinal cord compression	20.41	9.17	28	114402	4883	90509134
Pyrexia	20.40	9.17	657	113773	659828	89854189
Psychomotor hyperactivity	20.39	9.17	48	114382	12765	90501252
Orthostatic hypotension	20.23	9.17	14	114416	41813	90472204
Onychomycosis	20.18	9.17	11	114419	37365	90476652
Retrograde amnesia	20.01	9.17	11	114419	543	90513474
Purpura	19.96	9.17	52	114378	14726	90499291
Vasoplegia syndrome	19.87	9.17	21	114409	2793	90511224
Blood ethanol	19.79	9.17	5	114425	23	90513994
Induced abortion failed	19.71	9.17	8	114422	197	90513820
Intentional dose omission	19.50	9.17	58	114372	17725	90496292
Medical device site abscess	19.48	9.17	8	114422	203	90513814
Renal tubular necrosis	19.44	9.17	51	114379	14504	90499513
Ventricular extrasystoles	19.33	9.17	48	114382	13202	90500815
Adjustment disorder with depressed mood	19.31	9.17	26	114404	56727	90457290
Amphetamines positive	19.30	9.17	8	114422	208	90513809
Infusion site irritation	19.30	9.17	15	114415	1338	90512679
Blood pressure decreased	19.26	9.17	161	114269	74734	90439283
Dyspnoea	19.21	9.17	913	113517	880042	89633975
Opiates positive	19.18	9.17	9	114421	317	90513700
Multiple allergies	19.15	9.17	52	114378	15094	90498923
Arthritis bacterial	19.11	9.17	34	114396	7411	90506606
Foetal heart rate abnormal	19.03	9.17	13	114417	949	90513068
Tremor	18.94	9.17	285	114145	152888	90361129
Pupil fixed	18.92	9.17	18	114412	2110	90511907
Post procedural complication	18.92	9.17	60	114370	18982	90495035
Nerve root injury	18.83	9.17	6	114424	71	90513946
Punctate keratitis	18.76	9.17	12	114418	784	90513233
Pancytopenia	18.73	9.17	83	114347	120180	90393837
Bronchitis	18.70	9.17	284	114146	152643	90361374
Trigemino-cardiac reflex	18.68	9.17	6	114424	73	90513944
Acute respiratory failure	18.66	9.17	105	114325	42813	90471204
Foot deformity	18.65	9.17	29	114401	59622	90454395
Lethargy	18.57	9.17	140	114290	62999	90451018
Infusion site warmth	18.57	9.17	18	114412	2160	90511857
Dose calculation error	18.54	9.17	9	114421	342	90513675
Ear infection	18.48	9.17	151	114279	69624	90444393
Wrong product administered	18.40	9.17	34	114396	7631	90506386
Acute kidney injury	18.40	9.17	289	114141	320098	90193919
Neuromuscular block prolonged	18.34	9.17	11	114419	641	90513376
Product administration error	18.32	9.17	74	114356	26349	90487668
Hypoaesthesia oral	18.18	9.17	52	114378	15548	90498469
Autoimmune disorder	18.17	9.17	44	114386	76700	90437317
Atonic urinary bladder	18.11	9.17	7	114423	151	90513866
Lupus-like syndrome	18.06	9.17	21	114409	48825	90465192
Labelled drug-food interaction issue	17.90	9.17	5	114425	36	90513981
Leukopenia	17.89	9.17	66	114364	100644	90413373
Intentional self-injury	17.89	9.17	79	114351	29255	90484762
Nerve block	17.85	9.17	12	114418	853	90513164
Immunodeficiency	17.76	9.17	17	114413	43217	90470800
Muscle spasms	17.75	9.17	218	114212	251665	90262352
Haemoglobin increased	17.73	9.17	33	114397	7448	90506569
Respiratory distress	17.41	9.17	96	114334	38850	90475167
Stress	17.36	9.17	168	114262	81227	90432790
Device infusion issue	17.27	9.17	19	114411	2643	90511374
Paralysis	17.19	9.17	42	114388	11436	90502581
Glossoptosis	17.18	9.17	6	114424	96	90513921
Abortion spontaneous	17.17	9.17	26	114404	54030	90459987
Product dose omission issue	17.14	9.17	486	113944	291201	90222816
Airway peak pressure increased	17.06	9.17	9	114421	409	90513608
Inappropriate schedule of product administration	17.02	9.17	275	114155	149658	90364359
Walking aid user	17.02	9.17	12	114418	35494	90478523
Memory impairment	16.99	9.17	163	114267	197081	90316936
Brachial artery entrapment syndrome	16.92	9.17	5	114425	45	90513972
Vitamin D increased	16.88	9.17	12	114418	934	90513083
Nephrolithiasis	16.86	9.17	113	114317	48972	90465045
Eye movement disorder	16.81	9.17	29	114401	6169	90507848
Product distribution issue	16.74	9.17	22	114408	3683	90510334
Macular degeneration	16.71	9.17	14	114416	37956	90476061
Foetal death	16.67	9.17	3	114427	20720	90493297
Anaphylactoid shock	16.66	9.17	9	114421	429	90513588
Axillary nerve injury	16.64	9.17	5	114425	48	90513969
Substance abuser	16.61	9.17	7	114423	190	90513827
Skin infection	16.58	9.17	55	114375	17809	90496208
Hallucination, tactile	16.58	9.17	9	114421	433	90513584
Laboratory test abnormal	16.57	9.17	17	114413	41837	90472180
Taste disorder	16.46	9.17	33	114397	61513	90452504
Septic shock	16.41	9.17	53	114377	84107	90429910
Hypoproteinaemia	16.32	9.17	20	114410	3122	90510895
Neonatal seizure	16.30	9.17	10	114420	607	90513410
Maternal alcohol use	16.29	9.17	4	114426	16	90514001
Injection site abscess	16.28	9.17	14	114416	1440	90512577
Ataxia	16.26	9.17	55	114375	17987	90496030
Abdominal pain	16.25	9.17	378	114052	395343	90118674
Drug-induced liver injury	16.17	9.17	59	114371	90259	90423758
Coma scale abnormal	16.16	9.17	27	114403	5599	90508418
Retinal artery occlusion	16.13	9.17	17	114413	2254	90511763
Blood pressure immeasurable	15.97	9.17	14	114416	1478	90512539
Congenital umbilical hernia	15.92	9.17	8	114422	328	90513689
Inadequate analgesia	15.91	9.17	20	114410	3204	90510813
Piloerection	15.88	9.17	10	114420	636	90513381
Myelosuppression	15.87	9.17	27	114403	53564	90460453
Analgesic drug level increased	15.85	9.17	19	114411	2900	90511117
Injury	15.78	9.17	166	114264	197183	90316834
Apnoeic attack	15.76	9.17	8	114422	335	90513682
Device expulsion	15.75	9.17	17	114413	40869	90473148
Accidental exposure to product	15.44	9.17	99	114331	42267	90471750
Hypothermia	15.40	9.17	49	114381	15526	90498491
Infusion site discolouration	15.37	9.17	12	114418	1077	90512940
Pre-existing condition improved	15.30	9.17	35	114395	9134	90504883
Procedural complication	15.29	9.17	27	114403	5851	90508166
Drug tolerance decreased	15.22	9.17	11	114419	32119	90481898
Epilepsy	15.18	9.17	53	114377	82153	90431864
Anorgasmia	15.15	9.17	10	114420	690	90513327
Heliotrope rash	15.14	9.17	7	114423	238	90513779
Diplopia	15.06	9.17	74	114356	28640	90485377
Nail bed tenderness	15.03	9.17	8	114422	370	90513647
Vascular stenosis	14.97	9.17	9	114421	527	90513490
Anaphylactoid reaction	14.97	9.17	23	114407	4445	90509572
Supraventricular extrasystoles	14.79	9.17	25	114405	5232	90508785
Eye infarction	14.74	9.17	5	114425	73	90513944
Transferrin decreased	14.64	9.17	8	114422	390	90513627
Finger deformity	14.64	9.17	12	114418	32885	90481132
Brain injury	14.57	9.17	31	114399	7707	90506310
Spinal synovial cyst	14.55	9.17	5	114425	76	90513941
Product contamination	14.49	9.17	12	114418	1172	90512845
Educational problem	14.41	9.17	9	114421	564	90513453
Premenstrual dysphoric disorder	14.37	9.17	5	114425	79	90513938
Oedema peripheral	14.35	9.17	234	114196	257681	90256336
Apgar score low	14.32	9.17	12	114418	1191	90512826
Visual acuity reduced	14.24	9.17	63	114367	23347	90490670
Prescription drug used without a prescription	14.20	9.17	19	114411	3236	90510781
Ventricular arrhythmia	14.13	9.17	22	114408	4299	90509718
Administration site extravasation	14.09	9.17	12	114418	1218	90512799
Left ventricle outflow tract obstruction	14.03	9.17	8	114422	424	90513593
Acute hepatic failure	13.94	9.17	61	114369	22500	90491517
Infusion site infection	13.93	9.17	17	114413	2643	90511374
Tenderness	13.92	9.17	69	114361	26799	90487218
Monoplegia	13.87	9.17	20	114410	3654	90510363
Gastroenteritis	13.85	9.17	10	114420	29219	90484798
Right ventricular dysfunction	13.85	9.17	16	114414	2348	90511669
Delayed recovery from anaesthesia	13.79	9.17	11	114419	1019	90512998
Tonic posturing	13.74	9.17	3	114427	6	90514011
Nerve root injury cervical	13.74	9.17	3	114427	6	90514011
Drug resistance	13.68	9.17	11	114419	30438	90483579
Porphyria acute	13.63	9.17	3	114427	17972	90496045
Face oedema	13.62	9.17	62	114368	23256	90490761
Infantile apnoea	13.62	9.17	12	114418	1275	90512742
Hyperlipasaemia	13.60	9.17	10	114420	821	90513196
Genital erosion	13.52	9.17	8	114422	455	90513562
Chest pain	13.49	9.17	304	114126	319341	90194676
Injection site reaction	13.48	9.17	65	114365	92015	90422002
Device wireless communication issue	13.47	9.17	5	114425	96	90513921
Iron binding capacity total decreased	13.47	9.17	8	114422	458	90513559
Injection site atrophy	13.46	9.17	10	114420	834	90513183
Distributive shock	13.45	9.17	19	114411	3405	90510612
Poikiloderma	13.41	9.17	7	114423	311	90513706
Foreign body in respiratory tract	13.37	9.17	7	114423	313	90513704
Inappropriate antidiuretic hormone secretion	13.36	9.17	4	114426	19501	90494516
Incision site rash	13.35	9.17	4	114426	38	90513979
Dissociative amnesia	13.35	9.17	4	114426	38	90513979
Cardiotoxicity	13.31	9.17	38	114392	11351	90502666
Ejection fraction decreased	13.30	9.17	67	114363	26186	90487831
Localised infection	13.22	9.17	80	114350	33482	90480535
Osteonecrosis of jaw	13.21	9.17	18	114412	39085	90474932
Allergy to immunoglobulin therapy	13.18	9.17	6	114424	197	90513820
Eyelid contusion	13.15	9.17	5	114425	103	90513914
Cardiac failure congestive	13.13	9.17	72	114358	98622	90415395
Multiple organ dysfunction syndrome	13.10	9.17	138	114292	68198	90445819
Parasomnia	13.05	9.17	9	114421	667	90513350
Gastroenteritis viral	13.02	9.17	74	114356	30281	90483736
Intercepted medication error	12.91	9.17	10	114420	887	90513130
Anal sphincter atony	12.91	9.17	7	114423	336	90513681
Quadriparesis	12.88	9.17	16	114414	2533	90511484
Sinusitis bacterial	12.84	9.17	14	114416	1929	90512088
Hepatitis	12.80	9.17	46	114384	70693	90443324
Mean arterial pressure decreased	12.77	9.17	6	114424	212	90513805
Foetal heart rate decreased	12.77	9.17	6	114424	212	90513805
Pancreatitis acute	12.76	9.17	13	114417	32102	90481915
Orbital infection	12.76	9.17	5	114425	112	90513905
Oral herpes	12.63	9.17	79	114351	33445	90480572
Autonomic neuropathy	12.56	9.17	12	114418	1415	90512602
Cancer pain	12.48	9.17	20	114410	4005	90510012
Infusion site oedema	12.47	9.17	11	114419	1170	90512847
Toxicologic test abnormal	12.41	9.17	9	114421	723	90513294
Oedema	12.41	9.17	178	114252	200117	90313900
Infusion site inflammation	12.35	9.17	8	114422	534	90513483
Myocardial ischaemia	12.35	9.17	42	114388	13772	90500245
Vaginal abscess	12.35	9.17	8	114422	534	90513483
Conduction disorder	12.34	9.17	13	114417	1722	90512295
Muscular weakness	12.34	9.17	185	114245	206481	90307536
Alcohol intolerance	12.32	9.17	5	114425	123	90513894
Drug eruption	12.27	9.17	16	114414	35391	90478626
Floppy infant	12.17	9.17	5	114425	127	90513890
Haemangioma congenital	12.17	9.17	8	114422	548	90513469
Anterior chamber fibrin	12.03	9.17	5	114425	131	90513886
Tryptase increased	12.03	9.17	8	114422	559	90513458
Myoclonus	11.98	9.17	52	114378	19116	90494901
Disorientation	11.97	9.17	96	114334	44018	90469999
Implant site swelling	11.96	9.17	8	114422	564	90513453
Tachypnoea	11.96	9.17	56	114374	21253	90492764
Attention deficit hyperactivity disorder	11.91	9.17	20	114410	4164	90509853
Spinal operation	11.90	9.17	34	114396	10162	90503855
Incoherent	11.85	9.17	22	114408	4955	90509062
Hypertension	11.84	9.17	465	113965	457067	90056950
Vascular resistance systemic decreased	11.79	9.17	5	114425	138	90513879
Infusion site streaking	11.77	9.17	8	114422	579	90513438
Product preparation error	11.76	9.17	34	114396	10227	90503790
Interstitial lung disease	11.74	9.17	53	114377	76352	90437665
Body dysmorphic disorder	11.73	9.17	7	114423	404	90513613
Infusion site induration	11.66	9.17	12	114418	1547	90512470
Spinal stroke	11.63	9.17	4	114426	61	90513956
Bradypnoea	11.61	9.17	21	114409	4637	90509380
Multiple injuries	11.57	9.17	13	114417	1852	90512165
Infusion site scar	11.54	9.17	8	114422	598	90513419
Implant site bruising	11.50	9.17	7	114423	419	90513598
Haemoglobin decreased	11.47	9.17	140	114290	161816	90352201
Infection	11.43	9.17	359	114071	361735	90152282
Insomnia	11.43	9.17	327	114103	333147	90180870
Mixed anxiety and depressive disorder	11.40	9.17	7	114423	426	90513591
Renal impairment	11.40	9.17	82	114348	105339	90408678
Conjunctivitis	11.38	9.17	65	114365	26641	90487376
Pupillary reflex impaired	11.33	9.17	15	114415	2530	90511487
Laryngitis	11.32	9.17	30	114400	50723	90463294
Cellulitis	11.31	9.17	170	114260	91167	90422850
Feeling drunk	11.29	9.17	21	114409	4737	90509280
Arthritis fungal	11.28	9.17	4	114426	67	90513950
Tinnitus	11.26	9.17	93	114337	43009	90471008
Femur fracture	11.25	9.17	26	114404	46056	90467961
Peripheral vascular disorder	11.24	9.17	25	114405	6406	90507611
Proctalgia	11.23	9.17	29	114401	8169	90505848
Myocardial depression	11.23	9.17	8	114422	625	90513392
Product contamination microbial	11.22	9.17	6	114424	280	90513737
Asthma	11.18	9.17	227	114203	241933	90272084
Procedural anxiety	11.16	9.17	9	114421	847	90513170
Gastric mucosa erythema	11.09	9.17	7	114423	447	90513570
Cholestasis	11.01	9.17	18	114412	36281	90477736
Anaesthetic complication pulmonary	10.97	9.17	4	114426	73	90513944
Intraocular pressure fluctuation	10.97	9.17	4	114426	73	90513944
Therapy cessation	10.90	9.17	81	114349	36280	90477737
Renal cortical necrosis	10.90	9.17	6	114424	297	90513720
Ischaemia	10.89	9.17	22	114408	5273	90508744
Language disorder	10.84	9.17	15	114415	2637	90511380
Atelectasis	10.80	9.17	60	114370	24349	90489668
Pneumocystis jirovecii pneumonia	10.77	9.17	7	114423	21609	90492408
Birth mark	10.74	9.17	5	114425	173	90513844
Bone marrow failure	10.72	9.17	15	114415	32206	90481811
Upper gastrointestinal haemorrhage	10.71	9.17	8	114422	22968	90491049
Oxygen saturation decreased	10.69	9.17	193	114237	107290	90406727
Administration site erythema	10.68	9.17	9	114421	900	90513117
Hemiplegic migraine	10.68	9.17	5	114425	175	90513842
Exostosis	10.68	9.17	33	114397	53101	90460916
Drug abuser	10.68	9.17	15	114415	2675	90511342
Calcinosis	10.66	9.17	15	114415	2680	90511337
Medication error	10.65	9.17	158	114272	84494	90429523
Akinesia	10.59	9.17	12	114418	1724	90512293
Propionibacterium infection	10.58	9.17	3	114427	23	90513994
Pneumonia aspiration	10.52	9.17	88	114342	40852	90473165
Respiratory alkalosis	10.51	9.17	17	114413	3431	90510586
Sensory loss	10.51	9.17	48	114382	18027	90495990
Eclampsia	10.50	9.17	7	114423	491	90513526
Fear-related avoidance of activities	10.40	9.17	5	114425	186	90513831
Diplegia	10.40	9.17	11	114419	1464	90512553
Rash vesicular	10.35	9.17	5	114425	18192	90495825
Peritonitis	10.35	9.17	6	114424	19699	90494318
Incorrect product formulation administered	10.33	9.17	5	114425	189	90513828
Chemical burn	10.29	9.17	7	114423	508	90513509
Spinal cord oedema	10.28	9.17	5	114425	191	90513826
Hepatic enzyme decreased	10.27	9.17	9	114421	949	90513068
Accelerated idioventricular rhythm	10.27	9.17	4	114426	88	90513929
Maternal exposure timing unspecified	10.26	9.17	8	114422	22475	90491542
Nail bed inflammation	10.24	9.17	12	114418	1789	90512228
Imprisonment	10.22	9.17	6	114424	336	90513681
Blood pressure fluctuation	10.22	9.17	33	114397	52380	90461637
Conjunctival oedema	10.18	9.17	9	114421	960	90513057
Concussion	10.17	9.17	34	114396	11057	90502960
Application site alopecia	10.15	9.17	3	114427	27	90513990
Nodal rhythm	10.14	9.17	12	114418	1806	90512211
Aspiration	10.13	9.17	43	114387	15650	90498367
Impaired driving ability	10.06	9.17	21	114409	5152	90508865
Normal newborn	10.05	9.17	57	114373	23305	90490712
Drug detoxification	10.03	9.17	6	114424	348	90513669
Paraesthesia	10.02	9.17	240	114190	250086	90263931
Electrocardiogram PR shortened	9.97	9.17	7	114423	534	90513483
Nasal mucosal disorder	9.94	9.17	12	114418	1845	90512172
Retinal cyst	9.91	9.17	4	114426	97	90513920
Blood methaemoglobin present	9.91	9.17	4	114426	97	90513920
Spinal cord infarction	9.88	9.17	6	114424	358	90513659
Blood pressure systolic increased	9.87	9.17	39	114391	58306	90455711
Neuromuscular blockade	9.84	9.17	6	114424	360	90513657
Syringomyelia	9.80	9.17	5	114425	212	90513805
Repetitive strain injury	9.80	9.17	5	114425	212	90513805
Cholestasis of pregnancy	9.79	9.17	11	114419	1566	90512451
Pneumonia mycoplasmal	9.77	9.17	9	114421	1013	90513004
Hypoventilation	9.72	9.17	21	114409	5275	90508742
Alcoholic pancreatitis	9.70	9.17	3	114427	32	90513985
Allergy to metals	9.64	9.17	9	114421	1031	90512986
Haemorrhagic vasculitis	9.62	9.17	4	114426	105	90513912
Retinal haemorrhage	9.62	9.17	22	114408	5742	90508275
Coccygectomy	9.61	9.17	3	114427	33	90513984
Sympathectomy	9.61	9.17	3	114427	33	90513984
Incontinence	9.61	9.17	38	114392	13397	90500620
Viral infection	9.59	9.17	87	114343	41327	90472690
Creatinine renal clearance decreased	9.58	9.17	6	114424	18893	90495124
Red blood cell sedimentation rate decreased	9.58	9.17	9	114421	1039	90512978
Hyporesponsive to stimuli	9.57	9.17	11	114419	1606	90512411
Chills	9.52	9.17	226	114204	131755	90382262
Ependymoma	9.51	9.17	4	114426	108	90513909
Drug level above therapeutic	9.50	9.17	22	114408	5787	90508230
Depression	9.49	9.17	298	114132	300303	90213714
Metapneumovirus infection	9.49	9.17	10	114420	1325	90512692
Haemorrhoids	9.49	9.17	62	114368	26640	90487377
Hepatic failure	9.47	9.17	84	114346	39644	90474373
Multiple sclerosis relapse	9.47	9.17	34	114396	52271	90461746
Myasthenia gravis crisis	9.46	9.17	9	114421	1055	90512962
Allergy to chemicals	9.45	9.17	17	114413	3737	90510280
Genital ulceration	9.40	9.17	9	114421	1064	90512953
Disease recurrence	9.39	9.17	21	114409	37632	90476385
Diabetes mellitus inadequate control	9.38	9.17	6	114424	18678	90495339
Exposure via ingestion	9.32	9.17	14	114416	2653	90511364
Poor venous access	9.31	9.17	49	114381	19478	90494539
Foetal methotrexate syndrome	9.31	9.17	4	114426	114	90513903
Anorectal discomfort	9.31	9.17	15	114415	3019	90510998
Cerebral congestion	9.28	9.17	4	114426	115	90513902
Pustular psoriasis	9.26	9.17	6	114424	18550	90495467
Injection site infection	9.25	9.17	13	114417	2319	90511698
Kidney congestion	9.23	9.17	3	114427	38	90513979
Retinal detachment	9.21	9.17	24	114406	6798	90507219

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	5534.72	10.99	3031	76206	101740	42440358
Completed suicide	3576.50	10.99	2222	77015	94243	42447855
Toxicity to various agents	3556.96	10.99	3116	76121	226020	42316078
Cardio-respiratory arrest	727.96	10.99	708	78529	57928	42484170
Local anaesthetic systemic toxicity	600.64	10.99	207	79030	2093	42540005
Overdose	598.26	10.99	851	78386	104413	42437685
Substance use disorder	579.55	10.99	254	78983	5091	42537007
Intentional overdose	549.81	10.99	573	78664	50883	42491215
Drug use disorder	511.44	10.99	288	78949	10045	42532053
Alcohol interaction	454.15	10.99	165	79072	1970	42540128
Alcohol abuse	453.89	10.99	197	79040	3852	42538246
Intentional product misuse	414.15	10.99	542	78695	61358	42480740
Suspected suicide	388.24	10.99	202	79035	5997	42536101
Coma	373.94	10.99	479	78758	53075	42489023
Cardiac arrest	356.91	10.99	689	78548	108631	42433467
Substance abuse	312.60	10.99	199	79038	8706	42533392
Suicide attempt	301.01	10.99	399	78838	45701	42496397
Exposure to toxic agent	282.05	10.99	152	79085	4852	42537246
Poisoning	276.93	10.99	225	79012	14474	42527624
Drug dependence	275.31	10.99	304	78933	28790	42513308
Respiratory arrest	265.51	10.99	295	78942	28129	42513969
Asphyxia	234.01	10.99	162	79075	8164	42533934
Methaemoglobinaemia	232.96	10.99	141	79096	5633	42536465
Miosis	228.70	10.99	194	79043	13252	42528846
Anaphylactic shock	228.16	10.99	249	78988	23268	42518830
Respiratory depression	217.39	10.99	219	79018	18649	42523449
Alcohol poisoning	212.00	10.99	147	79090	7427	42534671
Tachycardia	167.13	10.99	489	78748	100598	42441500
Diarrhoea	161.21	10.99	390	78847	460459	42081639
Incorrect route of product administration	157.99	10.99	210	79027	24095	42518003
Anaphylactic reaction	151.12	10.99	279	78958	42464	42499634
Aggression	150.80	10.99	284	78953	43879	42498219
Inspiratory capacity decreased	150.30	10.99	84	79153	2883	42539215
Poisoning deliberate	147.81	10.99	134	79103	10000	42532098
Alcohol use	129.13	10.99	75	79162	2773	42539325
Prescription drug used without a prescription	118.79	10.99	70	79167	2660	42539438
Mydriasis	114.45	10.99	109	79128	8661	42533437
Death	108.26	10.99	1343	77894	469842	42072256
Anaesthetic complication	107.34	10.99	53	79184	1404	42540694
Agitation	106.09	10.99	311	78926	64003	42478095
Generalised tonic-clonic seizure	104.51	10.99	181	79056	26198	42515900
Fatigue	102.31	10.99	440	78797	435201	42106897
Unresponsive to stimuli	101.10	10.99	197	79040	31206	42510892
Disease progression	97.05	10.99	75	79162	143581	42398517
Hypotension	92.61	10.99	805	78432	256826	42285272
Toxic anterior segment syndrome	91.11	10.99	47	79190	1369	42540729
Blood alcohol increased	90.20	10.99	36	79201	564	42541534
Accidental death	86.65	10.99	60	79177	3023	42539075
Injury	85.64	10.99	151	79086	22165	42519933
Anaemia	81.45	10.99	259	78978	280019	42262079
Depressed level of consciousness	81.04	10.99	234	79003	47736	42494362
Interstitial lung disease	80.48	10.99	23	79214	78439	42463659
Decreased appetite	79.29	10.99	149	79088	192988	42349110
Acute kidney injury	77.83	10.99	385	78852	366952	42175146
Loss of consciousness	77.72	10.99	359	78878	91995	42450103
Weight decreased	76.40	10.99	171	79066	207777	42334321
Rash	74.26	10.99	265	78972	276689	42265409
Bradycardia	73.93	10.99	335	78902	85149	42456949
Neutropenia	69.24	10.99	169	79068	199262	42342836
Dyspnoea	66.19	10.99	517	78720	442104	42099994
Ventricular fibrillation	66.15	10.99	162	79075	29961	42512137
Off label use	65.98	10.99	816	78421	637519	41904579
Suicidal ideation	65.63	10.99	218	79019	47943	42494155
Drug screen positive	64.95	10.99	57	79180	4074	42538024
Electrocardiogram ST segment elevation	64.87	10.99	67	79170	5872	42536226
Asthenia	63.68	10.99	287	78950	280506	42261592
Brain oedema	63.32	10.99	111	79126	16216	42525882
Arthralgia	62.88	10.99	185	79052	205053	42337045
Adulterated product	59.83	10.99	29	79208	737	42541361
Accident	58.13	10.99	66	79171	6437	42535661
Malignant neoplasm progression	57.62	10.99	70	79167	108330	42433768
Electrocardiogram QRS complex prolonged	57.05	10.99	62	79175	5761	42536337
Haemoglobin decreased	56.28	10.99	100	79137	132371	42409727
General physical health deterioration	55.82	10.99	124	79113	151122	42390976
Ventricular tachycardia	55.71	10.99	152	79085	30008	42512090
Emotional distress	55.53	10.99	104	79133	15989	42526109
Behaviour disorder	55.41	10.99	67	79170	6987	42535111
Drug withdrawal syndrome	55.08	10.99	123	79114	21426	42520672
Thrombocytopenia	55.08	10.99	176	79061	190103	42351995
Alcohol withdrawal syndrome	54.86	10.99	34	79203	1417	42540681
Fear	53.95	10.99	83	79154	10882	42531216
Accidental overdose	51.56	10.99	142	79095	28188	42513910
Medication error	51.49	10.99	157	79080	32997	42509101
Cardiac failure congestive	51.33	10.99	50	79187	85552	42456546
Impaired driving ability	50.98	10.99	43	79194	2912	42539186
Pancytopenia	50.81	10.99	88	79149	117655	42424443
Bradypnoea	50.60	10.99	51	79186	4342	42537756
Pyrexia	50.47	10.99	479	78758	393563	42148535
Anal inflammation	48.15	10.99	37	79200	2192	42539906
Pulmonary oedema	47.71	10.99	211	79026	53061	42489037
Dehydration	46.95	10.99	123	79114	141644	42400454
Pain in extremity	45.91	10.99	136	79101	150468	42391630
Altered state of consciousness	45.85	10.99	139	79098	29120	42512978
Pruritus	45.77	10.99	188	79049	188583	42353515
Anhedonia	45.07	10.99	63	79174	7577	42534521
Myocardial infarction	44.66	10.99	103	79134	123906	42418192
Alcohol intolerance	44.65	10.99	19	79218	353	42541745
Somnolence	44.51	10.99	429	78808	140676	42401422
Sinus tachycardia	44.21	10.99	110	79127	20543	42521555
Haematochezia	44.09	10.99	27	79210	58409	42483689
SARS-CoV-2 test negative	44.00	10.99	32	79205	1743	42540355
Tubulointerstitial nephritis	43.93	10.99	4	79233	31544	42510554
Infusion site pain	43.62	10.99	52	79185	5343	42536755
Condition aggravated	43.47	10.99	295	78942	260459	42281639
Cough	43.41	10.99	177	79060	177926	42364172
Rheumatoid arthritis	42.49	10.99	13	79224	42427	42499671
Intentional product use issue	42.29	10.99	253	78984	71580	42470518
White blood cell count decreased	41.96	10.99	89	79148	110307	42431791
Weight increased	41.93	10.99	86	79151	107897	42434201
Renal injury	41.92	10.99	79	79158	12201	42529897
Myalgia	41.27	10.99	72	79165	96008	42446090
Leukopenia	41.06	10.99	47	79190	74699	42467399
Abdominal discomfort	40.61	10.99	48	79189	75207	42466891
Ex-drug abuser	40.54	10.99	12	79225	70	42542028
Psoriasis	40.23	10.99	20	79217	48584	42493514
Asthma	40.21	10.99	34	79203	62280	42479818
Oedema peripheral	39.96	10.99	125	79112	135951	42406147
Spinal cord infarction	39.69	10.99	21	79216	645	42541453
Neuropathy peripheral	38.80	10.99	82	79155	101771	42440327
Apnoea	38.29	10.99	59	79178	7744	42534354
Infusion site erythema	38.01	10.99	40	79197	3582	42538516
Prostate cancer	37.51	10.99	18	79219	44625	42497473
Pneumonia	37.51	10.99	556	78681	421593	42120505
Agranulocytosis	37.43	10.99	6	79231	30606	42511492
Shock	37.18	10.99	129	79108	28992	42513106
Malaise	36.35	10.99	238	78999	211918	42330180
Seizure	36.28	10.99	363	78874	120198	42421900
Road traffic accident	36.03	10.99	97	79140	18996	42523102
Intentional self-injury	35.78	10.99	84	79153	15118	42526980
Cardiogenic shock	35.65	10.99	146	79091	35494	42506604
Behavioural addiction	35.58	10.99	11	79226	76	42542022
Alcoholism	35.56	10.99	35	79202	2895	42539203
Respiratory acidosis	35.56	10.99	51	79186	6280	42535818
Renal impairment	35.45	10.99	97	79140	110131	42431967
Withdrawal syndrome	35.17	10.99	82	79155	14693	42527405
Trigemino-cardiac reflex	35.00	10.99	16	79221	355	42541743
Cauda equina syndrome	34.63	10.99	22	79215	958	42541140
Deep vein thrombosis	34.59	10.99	56	79181	76901	42465197
Hypoxia	34.41	10.99	235	79002	69551	42472547
Platelet count decreased	34.20	10.99	137	79100	138444	42403654
Dyspnoea exertional	34.06	10.99	26	79211	50122	42491976
Hyperthermia malignant	32.72	10.99	32	79205	2626	42539472
Loss of personal independence in daily activities	32.36	10.99	27	79210	49789	42492309
Cytomegalovirus infection	32.15	10.99	10	79227	32296	42509802
Drug abuser	31.84	10.99	36	79201	3495	42538603
Myelosuppression	31.50	10.99	18	79219	40443	42501655
Kounis syndrome	31.50	10.99	35	79202	3333	42538765
Blood ethanol	30.86	10.99	10	79227	82	42542016
Nausea	30.76	10.99	536	78701	396263	42145835
Myoclonus	30.51	10.99	85	79152	16980	42525118
Status epilepticus	30.26	10.99	80	79157	15498	42526600
Restlessness	30.19	10.99	121	79116	29128	42512970
Drug resistance	30.03	10.99	13	79224	34235	42507863
Opiates positive	29.11	10.99	16	79221	531	42541567
Therapeutic product effect incomplete	28.82	10.99	55	79182	70884	42471214
Homicide	28.55	10.99	19	79218	896	42541202
Postmortem blood drug level	28.30	10.99	11	79226	160	42541938
Infusion site extravasation	27.68	10.99	42	79195	5439	42536659
Insurance issue	27.41	10.99	36	79201	4080	42538018
Blood pressure systolic increased	27.22	10.99	9	79228	27959	42514139
Myocardial fibrosis	27.18	10.99	21	79216	1254	42540844
Drug reaction with eosinophilia and systemic symptoms	27.09	10.99	23	79214	42052	42500046
Foetal alcohol syndrome	26.84	10.99	9	79228	83	42542015
Dysarthria	26.56	10.99	145	79092	39662	42502436
Pneumocystis jirovecii pneumonia	26.52	10.99	7	79230	25174	42516924
Melaena	26.42	10.99	20	79217	38726	42503372
Cardiac failure	26.13	10.99	106	79131	106750	42435348
Sensorimotor disorder	25.94	10.99	14	79223	448	42541650
Dizziness	25.79	10.99	318	78919	248936	42293162
Coronary artery disease	25.18	10.99	38	79199	53682	42488416
Amnesia	24.97	10.99	112	79125	28325	42513773
Bronchospasm	24.86	10.99	66	79171	12819	42529279
Hypertonia	24.80	10.99	38	79199	4963	42537135
Arthritis	24.71	10.99	25	79212	42040	42500058
Circulatory collapse	24.57	10.99	98	79139	23538	42518560
Removal of foreign body	24.54	10.99	6	79231	14	42542084
Frequent bowel movements	24.43	10.99	5	79232	21402	42520696
Oculocardiac reflex	24.14	10.99	9	79228	116	42541982
Eczema	24.02	10.99	17	79220	34069	42508029
Metabolic acidosis	24.02	10.99	172	79065	51686	42490412
Dyspepsia	23.81	10.99	25	79212	41327	42500771
Pulmonary fibrosis	23.60	10.99	10	79227	26671	42515427
Pupil fixed	23.45	10.99	23	79214	1894	42540204
Proctalgia	23.43	10.99	45	79192	7048	42535050
Disease recurrence	23.39	10.99	13	79224	29665	42512433
Gastrointestinal haemorrhage	23.23	10.99	98	79139	97628	42444470
Blood ethanol increased	22.97	10.99	13	79224	457	42541641
Hepatic function abnormal	22.72	10.99	38	79199	51529	42490569
Bone marrow failure	22.67	10.99	17	79220	33076	42509022
Angina pectoris	22.41	10.99	17	79220	32879	42509219
Rectal haemorrhage	22.38	10.99	36	79201	49570	42492528
Blood pressure fluctuation	22.37	10.99	11	79226	26897	42515201
Hypoxic-ischaemic encephalopathy	22.32	10.99	37	79200	5165	42536933
Anaesthetic complication neurological	22.29	10.99	15	79222	721	42541377
Toxicologic test abnormal	22.23	10.99	13	79224	487	42541611
Hypothermia	22.04	10.99	62	79175	12453	42529645
Delirium tremens	21.87	10.99	14	79223	618	42541480
Gastrointestinal disorder	21.86	10.99	33	79204	46620	42495478
Septic shock	21.75	10.99	92	79145	91580	42450518
Postmortem blood drug level increased	21.73	10.99	13	79224	508	42541590
Ventricular tachyarrhythmia	21.70	10.99	12	79225	403	42541695
Acute pulmonary oedema	21.68	10.99	49	79188	8602	42533496
Blood creatinine increased	21.66	10.99	118	79119	109885	42432213
Somnambulism	21.40	10.99	29	79208	3386	42538712
Wrong product administered	21.18	10.99	40	79197	6186	42535912
Hypercalcaemia	21.07	10.99	4	79233	18054	42524044
Dextrocardia	21.03	10.99	7	79230	63	42542035
Haemodynamic instability	20.95	10.99	61	79176	12496	42529602
Administration related reaction	20.92	10.99	9	79228	172	42541926
Colitis	20.82	10.99	34	79203	46538	42495560
Haematuria	20.80	10.99	48	79189	57751	42484347
Chronic kidney disease	20.64	10.99	35	79202	47206	42494892
Embolia cutis medicamentosa	20.64	10.99	11	79226	343	42541755
Liver disorder	20.63	10.99	26	79211	39618	42502480
Arthropathy	20.54	10.99	15	79222	29582	42512516
Macular ischaemia	20.50	10.99	9	79228	181	42541917
Diabetic ketoacidosis	20.40	10.99	8	79229	22359	42519739
Joint swelling	20.29	10.99	62	79175	67960	42474138
Drug level increased	19.94	10.99	99	79138	26101	42515997
Transient ischaemic attack	19.88	10.99	20	79217	33719	42508379
Open globe injury	19.86	10.99	7	79230	76	42542022
Tracheitis	19.76	10.99	16	79221	1023	42541075
Corneal oedema	19.74	10.99	19	79218	1529	42540569
Neoplasm progression	19.73	10.99	15	79222	28985	42513113
Alcoholic coma	19.70	10.99	7	79230	78	42542020
Full blood count abnormal	19.64	10.99	16	79221	29860	42512238
Drug ineffective for unapproved indication	19.60	10.99	150	79087	46013	42496085
Product administration interrupted	19.56	10.99	34	79203	4932	42537166
Negative pressure pulmonary oedema	19.56	10.99	13	79224	612	42541486
Abnormal behaviour	19.47	10.99	99	79138	26352	42515746
Infusion site swelling	19.20	10.99	27	79210	3265	42538833
Physical assault	19.19	10.99	16	79221	1066	42541032
Blood phosphorus increased	19.15	10.99	59	79178	12466	42529632
Retinal artery occlusion	18.99	10.99	22	79215	2193	42539905
C-reactive protein increased	18.91	10.99	58	79179	63502	42478596
Vasoplegia syndrome	18.90	10.99	24	79213	2631	42539467
Underdose	18.80	10.99	4	79233	16662	42525436
Brain stem syndrome	18.61	10.99	13	79224	664	42541434
Tryptase increased	18.53	10.99	10	79227	320	42541778
Colitis ulcerative	18.51	10.99	13	79224	26162	42515936
Plasma cell myeloma	18.36	10.99	38	79199	47540	42494558
Constipation	18.33	10.99	203	79034	162088	42380010
Dry skin	18.33	10.99	39	79198	48299	42493799
Dysgeusia	18.23	10.99	22	79215	34167	42507931
Proteinuria	18.21	10.99	10	79227	22973	42519125
Respiratory tract infection bacterial	18.13	10.99	20	79217	1889	42540209
Sleep disorder due to a general medical condition	18.10	10.99	5	79232	17448	42524650
Sinusitis	18.08	10.99	150	79087	47142	42494956
Spinal meningeal cyst	18.00	10.99	7	79230	102	42541996
Mental status changes	17.97	10.99	137	79100	41978	42500120
Substance-induced mood disorder	17.93	10.99	6	79231	55	42542043
Chemical burn	17.90	10.99	10	79227	343	42541755
Abdominal pain	17.85	10.99	248	78989	190223	42351875
Jaundice	17.67	10.99	23	79214	34566	42507532
Mean arterial pressure increased	17.64	10.99	6	79231	58	42542040
Postoperative delirium	17.62	10.99	12	79225	588	42541510
Torsade de pointes	17.58	10.99	45	79192	8549	42533549
Neutrophil count decreased	17.39	10.99	60	79177	63355	42478743
International normalised ratio increased	17.33	10.99	40	79197	48128	42493970
Visceral oedema	17.20	10.99	6	79231	63	42542035
Cerebrovascular accident	17.12	10.99	108	79129	97052	42445046
Lymphoma	17.08	10.99	3	79234	14318	42527780
Bezoar	16.91	10.99	16	79221	1260	42540838
Stress	16.77	10.99	140	79097	44072	42498026
Syncope	16.75	10.99	112	79125	99294	42442804
Amphetamines positive	16.70	10.99	8	79229	198	42541900
Hyperkalaemia	16.57	10.99	85	79152	80373	42461725
Mobility decreased	16.52	10.99	25	79212	35281	42506817
Peritonitis	16.45	10.99	7	79230	18626	42523472
Analgesic therapy	16.40	10.99	37	79200	6487	42535611
Pneumonitis	16.37	10.99	33	79204	41685	42500413
Hepatitis	16.29	10.99	16	79221	27284	42514814
Lagophthalmos	16.26	10.99	7	79230	134	42541964
Therapeutic product effect decreased	16.21	10.99	30	79207	39120	42502978
Paraesthesia oral	16.13	10.99	32	79205	5131	42536967
Brachial plexus injury	16.12	10.99	6	79231	77	42542021
Suicidal behaviour	16.09	10.99	17	79220	1529	42540569
Haemoptysis	16.08	10.99	39	79198	46128	42495970
Substance use	16.04	10.99	18	79219	1733	42540365
Chemical submission	15.98	10.99	6	79231	79	42542019
Aqueous fibrin	15.98	10.99	6	79231	79	42542019
Orthostatic hypotension	15.95	10.99	20	79217	30550	42511548
Postictal state	15.89	10.99	14	79223	1006	42541092
Appendicolith	15.80	10.99	58	79179	13398	42528700
Thrombotic microangiopathy	15.78	10.99	4	79233	14778	42527320
Cardiac disorder	15.76	10.99	43	79194	48889	42493209
Psychiatric disorder prophylaxis	15.76	10.99	5	79232	38	42542060
Ear infection	15.72	10.99	56	79181	12748	42529350
Bladder cancer	15.71	10.99	6	79231	17041	42525057
Eosinophilia	15.68	10.99	23	79214	32876	42509222
Muscular weakness	15.66	10.99	91	79146	83407	42458691
Intracranial hypotension	15.63	10.99	10	79227	441	42541657
Toxic leukoencephalopathy	15.56	10.99	12	79225	715	42541383
Brugada syndrome	15.50	10.99	14	79223	1039	42541059
Sepsis	15.47	10.99	269	78968	199065	42343033
Red blood cell count decreased	15.46	10.99	23	79214	32692	42509406
Alopecia	15.44	10.99	19	79218	29257	42512841
Diabetes insipidus	15.39	10.99	26	79211	3687	42538411
Neuromuscular blockade	15.27	10.99	9	79228	342	42541756
Infection	15.24	10.99	134	79103	111934	42430164
Hyperaesthesia	15.24	10.99	34	79203	5918	42536180
Hyperphosphataemia	15.22	10.99	56	79181	12948	42529150
Lip haemorrhage	15.08	10.99	13	79224	907	42541191
Peripheral swelling	15.06	10.99	102	79135	90168	42451930
Self-medication	15.06	10.99	24	79213	3242	42538856
Seizure like phenomena	15.01	10.99	14	79223	1083	42541015
Polyneuropathy	14.96	10.99	8	79229	18653	42523445
Multiple sclerosis relapse	14.96	10.99	4	79233	14260	42527838
Musculoskeletal stiffness	14.94	10.99	56	79181	57709	42484389
Pulse absent	14.93	10.99	35	79202	6292	42535806
Wheezing	14.91	10.99	52	79185	54729	42487369
Analgesic drug level increased	14.89	10.99	14	79223	1094	42541004
Reperfusion arrhythmia	14.86	10.99	6	79231	97	42542001
Accidental poisoning	14.84	10.99	15	79222	1281	42540817
Electrocution	14.75	10.99	4	79233	16	42542082
Hypothyroidism	14.74	10.99	23	79214	32061	42510037
Drug therapy	14.74	10.99	35	79202	6345	42535753
Mucosal inflammation	14.73	10.99	45	79192	49329	42492769
Drowning	14.65	10.99	10	79227	492	42541606
Cardiac murmur	14.55	10.99	3	79234	12772	42529326
Postmortem blood drug level abnormal	14.52	10.99	9	79228	375	42541723
Endophthalmitis	14.49	10.99	28	79209	4405	42537693
Product administration error	14.45	10.99	70	79167	18273	42523825
Product adhesion issue	14.45	10.99	17	79220	1722	42540376
Neurotoxicity	14.36	10.99	84	79153	23567	42518531
Injection site ulcer	14.35	10.99	9	79228	383	42541715
Haemophagocytic lymphohistiocytosis	14.33	10.99	8	79229	18214	42523884
Dysphagia	14.31	10.99	78	79159	72641	42469457
Infusion site irritation	14.27	10.99	9	79228	387	42541711
Patient uncooperative	14.19	10.99	11	79226	660	42541438
Acute myocardial infarction	14.02	10.99	58	79179	58107	42483991
Sleep disorder therapy	14	10.99	36	79201	6858	42535240
Blood glucose increased	13.99	10.99	80	79157	73619	42468479
Respiratory paralysis	13.88	10.99	6	79231	116	42541982
Anxiety	13.88	10.99	303	78934	118257	42423841
Ventricular asystole	13.87	10.99	8	79229	292	42541806
Clostridium difficile infection	13.85	10.99	13	79224	22646	42519452
Hepatic fibrosis	13.81	10.99	29	79208	4843	42537255
Gun shot wound	13.74	10.99	13	79224	1024	42541074
Pericarditis	13.67	10.99	4	79233	13440	42528658
Lymphopenia	13.62	10.99	12	79225	21551	42520547
Full blood count decreased	13.53	10.99	11	79226	20549	42521549
Synovitis	13.50	10.99	6	79231	15561	42526537
Benzodiazepine drug level therapeutic	13.42	10.99	4	79233	24	42542074
Accidental exposure to product	13.41	10.99	74	79163	20319	42521779
Psoriatic arthropathy	13.38	10.99	16	79221	24951	42517147
Alcoholic pancreatitis	13.32	10.99	7	79230	212	42541886
Insomnia	13.31	10.99	148	79089	118105	42423993
Type 2 diabetes mellitus	13.29	10.99	9	79228	18462	42523636
Pneumonia aspiration	13.26	10.99	147	79090	49931	42492167
Vasculitis	13.19	10.99	9	79228	18385	42523713
Metastases to liver	13.09	10.99	7	79230	16319	42525779
Catecholamine crisis	13.04	10.99	5	79232	70	42542028
Respiratory tract infection viral	13.00	10.99	23	79214	3383	42538715
Type I hypersensitivity	12.98	10.99	18	79219	2148	42539950
Screaming	12.92	10.99	17	79220	1930	42540168
Nystagmus	12.90	10.99	30	79207	5366	42536732
Pleural effusion	12.85	10.99	117	79120	97049	42445049
Drug interaction	12.83	10.99	613	78624	266386	42275712
Kidney congestion	12.81	10.99	9	79228	464	42541634
Administration site pain	12.80	10.99	9	79228	465	42541633
Ophthalmoplegia	12.76	10.99	18	79219	2182	42539916
Infusion site bruising	12.74	10.99	12	79225	940	42541158
Psychotic behaviour	12.72	10.99	12	79225	942	42541156
Unevaluable event	12.70	10.99	108	79129	34180	42507918
Lung disorder	12.70	10.99	46	79191	47877	42494221
Product prescribing error	12.69	10.99	18	79219	26094	42516004
Muscle spasms	12.54	10.99	101	79136	85943	42456155
Prostatic pain	12.54	10.99	8	79229	351	42541747
Abdominal pain upper	12.49	10.99	96	79141	82513	42459585
Drug diversion	12.37	10.99	12	79225	975	42541123
Potentiating drug interaction	12.34	10.99	33	79204	6435	42535663
Myasthenia gravis	12.30	10.99	61	79176	16076	42526022
Pulmonary embolism	12.19	10.99	153	79084	119459	42422639
Blood pH decreased	12.16	10.99	18	79219	2280	42539818
Gastritis	12.15	10.99	16	79221	23931	42518167
Corneal opacity	12.14	10.99	10	79227	655	42541443
Thyrotoxic crisis	12.10	10.99	11	79226	823	42541275
Anal sphincter atony	12.05	10.99	6	79231	162	42541936
Vitreous disorder	11.98	10.99	6	79231	164	42541934
Intestinal obstruction	11.98	10.99	20	79217	27138	42514960
Electrocardiogram QT prolonged	11.91	10.99	139	79098	47806	42494292
Upper gastrointestinal haemorrhage	11.86	10.99	24	79213	30275	42511823
Gastroenteritis	11.86	10.99	8	79229	16441	42525657
Device effect incomplete	11.82	10.99	4	79233	38	42542060
Spinal operation	11.82	10.99	25	79212	4195	42537903
Diabetes mellitus inadequate control	11.76	10.99	7	79230	15383	42526715
Painful ejaculation	11.69	10.99	6	79231	173	42541925
Encephalomalacia	11.64	10.99	12	79225	1049	42541049
Coma scale abnormal	11.60	10.99	26	79211	4539	42537559
Sopor	11.59	10.99	52	79185	13150	42528948
Phlebitis superficial	11.58	10.99	7	79230	279	42541819
Impaired work ability	11.58	10.99	4	79233	12087	42530011
Blood lactic acid increased	11.49	10.99	37	79200	8002	42534096
Enterobacter pneumonia	11.44	10.99	9	79228	552	42541546
Palpitations	11.42	10.99	52	79185	50745	42491353
Electrocardiogram T wave amplitude increased	11.32	10.99	5	79232	102	42541996
Hanging	11.32	10.99	6	79231	185	42541913
Pulseless electrical activity	11.31	10.99	38	79199	8399	42533699
Chemical poisoning	11.28	10.99	5	79232	103	42541995
Phaeochromocytoma crisis	11.23	10.99	5	79232	104	42541994
Alcoholic liver disease	11.22	10.99	9	79228	568	42541530
Hypoventilation	11.21	10.99	23	79214	3779	42538319
Pancreatitis acute	11.18	10.99	29	79208	33535	42508563
Graft versus host disease	11.18	10.99	5	79232	12920	42529178
Laryngospasm	11.14	10.99	16	79221	1972	42540126
Conjunctival scar	11.14	10.99	7	79230	299	42541799
Nephropathy toxic	11.09	10.99	9	79228	16829	42525269
Aspergillus infection	11.02	10.99	8	79229	15829	42526269
Laboratory test abnormal	11.01	10.99	16	79221	22962	42519136

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	8651.90	9.65	5014	158103	237367	110188815
Drug abuse	7522.27	9.65	4112	159005	173299	110252883
Toxicity to various agents	7066.25	9.65	5746	157371	474809	109951373
Cardio-respiratory arrest	1874.10	9.65	1472	161645	114364	110311818
Local anaesthetic systemic toxicity	1586.78	9.65	505	162612	5032	110421150
Intentional overdose	1125.69	9.65	1172	161945	131329	110294853
Cardiac arrest	1054.68	9.65	1373	161744	195380	110230802
Overdose	1026.21	9.65	1481	161636	232313	110193869
Alcohol interaction	828.72	9.65	280	162837	3414	110422768
Substance use disorder	824.70	9.65	334	162783	6956	110419226
Suspected suicide	819.03	9.65	415	162702	14784	110411398
Drug use disorder	707.72	9.65	399	162718	17675	110408507
Intentional product misuse	652.52	9.65	889	162228	132015	110294167
Exposure to toxic agent	651.98	9.65	337	162780	12521	110413661
Respiratory arrest	594.81	9.65	570	162547	57729	110368453
Suicide attempt	550.98	9.65	720	162397	102674	110323508
Coma	541.91	9.65	764	162353	117105	110309077
Death	541.72	9.65	2250	160867	696619	109729563
Anaphylactic shock	493.98	9.65	487	162630	51059	110375123
Alcohol abuse	470.29	9.65	200	162917	4729	110421453
Methaemoglobinaemia	469.75	9.65	242	162875	8926	110417256
Alcohol poisoning	388.35	9.65	212	162905	8808	110417374
Substance abuse	379.80	9.65	234	162883	12229	110413953
Poisoning	370.00	9.65	322	162795	28783	110397399
Anaphylactic reaction	369.74	9.65	630	162487	113670	110312512
Drug dependence	331.80	9.65	389	162728	49631	110376551
Synovitis	318.69	9.65	22	163095	274070	110152112
Maternal exposure during delivery	305.21	9.65	134	162983	3431	110422751
Toxic anterior segment syndrome	302.75	9.65	132	162985	3322	110422860
Hypotension	283.53	9.65	1521	161596	522328	109903854
Generalised tonic-clonic seizure	282.21	9.65	375	162742	54305	110371877
Victim of crime	275.81	9.65	96	163021	1287	110424895
Poisoning deliberate	275.23	9.65	261	162856	26070	110400112
Miosis	266.98	9.65	237	162880	21746	110404436
Tachycardia	256.21	9.65	826	162291	225819	110200363
Respiratory depression	255.25	9.65	274	162843	31727	110394455
Asphyxia	249.83	9.65	190	162927	14025	110412157
Mydriasis	247.70	9.65	228	162889	21929	110404253
Alcohol use	244.02	9.65	120	162997	4002	110422180
Hand deformity	238.85	9.65	23	163094	218483	110207699
Systemic lupus erythematosus	237.18	9.65	44	163073	254294	110171888
Pericarditis	237.06	9.65	24	163093	219090	110207092
Pemphigus	236.10	9.65	22	163095	214548	110211634
Hepatic enzyme increased	234.37	9.65	90	163027	320802	110105380
Agitation	234.01	9.65	516	162601	112535	110313647
Joint swelling	230.47	9.65	189	162928	442656	109983526
Glossodynia	216.71	9.65	34	163083	221970	110204212
Anaesthetic complication	213.54	9.65	105	163012	3501	110422681
Helicobacter infection	210.20	9.65	15	163102	181862	110244320
Diarrhoea	209.95	9.65	917	162200	1138588	109287594
Incorrect route of product administration	203.00	9.65	350	162767	63711	110362471
Abdominal discomfort	201.32	9.65	171	162946	393687	110032495
Seizure	201.12	9.65	750	162367	220435	110205747
General physical health deterioration	200.39	9.65	199	162918	425096	110001086
Unresponsive to stimuli	200.15	9.65	347	162770	63443	110362739
Anti-cyclic citrullinated peptide antibody positive	194.10	9.65	21	163096	181963	110244219
Aggression	192.22	9.65	327	162790	58883	110367299
Infusion related reaction	184.60	9.65	174	162943	380988	110045194
Duodenal ulcer perforation	183.32	9.65	23	163094	177677	110248505
Mobility decreased	182.85	9.65	61	163056	237361	110188821
Arthralgia	180.23	9.65	571	162546	779061	109647121
Loss of consciousness	175.41	9.65	662	162455	195644	110230538
Alopecia	172.57	9.65	170	162947	364583	110061599
Kounis syndrome	172.32	9.65	108	163009	5817	110420365
Psoriatic arthropathy	165.30	9.65	43	163074	196718	110229464
Bradycardia	164.21	9.65	554	162563	154963	110271219
Arthropathy	156.71	9.65	117	163000	287405	110138777
Somnolence	156.07	9.65	857	162260	296592	110129590
Folliculitis	154.15	9.65	30	163087	167623	110258559
Wound	153.36	9.65	77	163040	234360	110191822
Rheumatoid factor positive	151.69	9.65	11	163106	131629	110294553
Rash	148.87	9.65	664	162453	820300	109605882
Blood alcohol increased	147.74	9.65	56	163061	970	110425212
Muscle injury	143.36	9.65	19	163098	140788	110285394
Ventricular fibrillation	143.22	9.65	235	162882	41078	110385104
Inspiratory capacity decreased	143.12	9.65	72	163045	2523	110423659
Type 2 diabetes mellitus	142.77	9.65	42	163075	177190	110248992
Ventricular tachycardia	142.69	9.65	261	162856	49748	110376434
Chemical submission	142.16	9.65	47	163070	533	110425649
Electrocardiogram QRS complex prolonged	141.69	9.65	132	162985	12889	110413293
Depressed level of consciousness	141.36	9.65	425	162692	111853	110314329
Drug intolerance	138.42	9.65	242	162875	406270	110019912
Rheumatic fever	136.34	9.65	12	163105	122567	110303615
Impaired healing	135.75	9.65	60	163057	196657	110229525
Fatigue	134.62	9.65	1148	161969	1214810	109211372
Therapeutic product effect decreased	124.85	9.65	106	163011	244210	110181972
Rheumatoid arthritis	123.74	9.65	156	162961	299457	110126725
Sinus tachycardia	122.90	9.65	229	162888	44264	110381918
Prescription drug used without a prescription	120.53	9.65	84	163033	5412	110420770
Contraindicated product administered	118.19	9.65	115	163002	248152	110178030
Accidental death	117.98	9.65	80	163037	4929	110421253
Irritable bowel syndrome	116.64	9.65	48	163069	164167	110262015
Asthenia	115.54	9.65	573	162544	688426	109737756
Anaesthetic complication neurological	112.28	9.65	46	163071	987	110425195
Pulseless electrical activity	112.22	9.65	131	162986	16626	110409556
Stress cardiomyopathy	111.63	9.65	127	162990	15679	110410503
Pulmonary oedema	111.04	9.65	364	162753	100295	110325887
Osteoarthritis	106.51	9.65	69	163048	182554	110243628
Sleep disorder due to general medical condition, insomnia type	105.77	9.65	15	163102	105628	110320554
Lower respiratory tract infection	105.22	9.65	122	162995	242984	110183198
Ill-defined disorder	104.86	9.65	50	163067	156803	110269379
Apnoea	103.89	9.65	114	163003	13525	110412657
Electrocardiogram ST segment elevation	103.82	9.65	95	163022	9065	110417117
Decreased appetite	103.22	9.65	358	162759	475488	109950694
Fear	100.11	9.65	146	162971	23047	110403135
Abdominal pain upper	99.81	9.65	230	162887	348881	110077301
Cardiogenic shock	99.18	9.65	244	162873	57094	110369088
Peripheral venous disease	96.99	9.65	7	163110	84110	110342072
Suicidal ideation	95.92	9.65	331	162786	93606	110332576
Swelling	95.81	9.65	237	162880	350804	110075378
Weight increased	92.84	9.65	313	162804	419331	110006851
Facet joint syndrome	91.85	9.65	16	163101	96812	110329370
Lip dry	91.80	9.65	18	163099	100065	110326117
Fibromyalgia	91.22	9.65	71	163046	170838	110255344
Nasopharyngitis	90.79	9.65	289	162828	394072	110032110
Disease progression	90.76	9.65	137	162980	243897	110182285
Inflammation	90.24	9.65	91	163026	193147	110233035
Brain oedema	89.59	9.65	163	162954	30935	110395247
Obesity	89.22	9.65	28	163089	113323	110312859
Procedural hypotension	89.21	9.65	52	163065	2453	110423729
Stomatitis	89.12	9.65	164	162953	270078	110156104
Accidental overdose	89.04	9.65	220	162897	51614	110374568
Hypersensitivity	88.91	9.65	302	162815	403696	110022486
Gait inability	88.84	9.65	45	163072	136331	110289851
Withdrawal syndrome	88.53	9.65	163	162954	31217	110394965
Drug interaction	87.88	9.65	1125	161992	499058	109927124
Pruritus	87.23	9.65	502	162615	581058	109845124
Peripheral swelling	86.90	9.65	305	162812	403729	110022453
Musculoskeletal stiffness	86.90	9.65	176	162941	279646	110146536
Blister	86.16	9.65	126	162991	227250	110198932
Mental status changes	85.50	9.65	277	162840	75845	110350337
Status epilepticus	85.33	9.65	161	162956	31410	110394772
Gastrointestinal disorder	84.16	9.65	142	162975	241810	110184372
Swollen joint count increased	83.47	9.65	12	163105	83649	110342533
Shock	83.29	9.65	219	162898	53369	110372813
Condition aggravated	83.20	9.65	689	162428	734147	109692035
Emotional distress	83.10	9.65	196	162921	44651	110381531
Hypoxia	80.22	9.65	391	162726	129124	110297058
Hypercholesterolaemia	79.89	9.65	18	163099	90819	110335363
Behaviour disorder	79.39	9.65	84	163033	9563	110416619
Pulse absent	78.51	9.65	90	163027	11202	110414980
Nystagmus	78.35	9.65	91	163026	11486	110414696
Body tinea	78.23	9.65	45	163072	2070	110424112
C-reactive protein increased	77.55	9.65	126	162991	217793	110208389
Sulphaemoglobinaemia	76.83	9.65	30	163087	565	110425617
Renal injury	76.74	9.65	115	163002	18598	110407584
Wheezing	76.32	9.65	164	162953	255066	110171116
Off label use	75.14	9.65	1665	161452	1498520	108927662
Neutropenia	74.53	9.65	292	162825	374328	110051854
Malaise	74.18	9.65	634	162483	671185	109754997
Pulmonary fibrosis	73.80	9.65	29	163088	102013	110324169
Embolia cutis medicamentosa	72.23	9.65	33	163084	930	110425252
Bursitis	71.86	9.65	52	163065	129866	110296316
Drug screen positive	71.71	9.65	66	163051	6344	110419838
Postmortem blood drug level abnormal	71.27	9.65	29	163088	611	110425571
Circulatory collapse	71.25	9.65	180	162937	42813	110383369
Thrombocytopenia	70.64	9.65	270	162847	348615	110077567
Altered state of consciousness	69.57	9.65	215	162902	57411	110368771
Anhedonia	69.33	9.65	99	163018	15329	110410853
Victim of chemical submission	68.70	9.65	31	163086	848	110425334
Corneal oedema	68.42	9.65	48	163069	3125	110423057
Joint range of motion decreased	68.39	9.65	48	163069	121784	110304398
Cauda equina syndrome	67.61	9.65	41	163076	2081	110424101
Restlessness	66.17	9.65	208	162909	56051	110370131
Drug level increased	66.15	9.65	187	162930	47532	110378650
Alcoholism	66.13	9.65	50	163067	3657	110422525
Dyspnoea	65.64	9.65	1194	161923	1105678	109320504
Alcohol withdrawal syndrome	64.91	9.65	40	163077	2090	110424092
Weight decreased	64.90	9.65	414	162703	467643	109958539
Bronchospasm	64.77	9.65	140	162977	30099	110396083
Lung disorder	64.15	9.65	104	163013	179943	110246239
Respiratory acidosis	64.02	9.65	90	163027	13736	110412446
Pyrexia	63.44	9.65	938	162179	897327	109528855
Electrocardiogram QT prolonged	63.26	9.65	323	162794	108637	110317545
Breast cancer stage III	63.24	9.65	19	163098	79098	110347084
Psoriasis	63.02	9.65	68	163049	139925	110286257
Interstitial lung disease	62.36	9.65	68	163049	139266	110286916
Victim of sexual abuse	62.00	9.65	25	163092	514	110425668
Liver disorder	61.94	9.65	71	163046	142172	110284010
Acute kidney injury	61.77	9.65	619	162498	634811	109791371
Grip strength decreased	60.99	9.65	21	163096	80153	110346029
Drug withdrawal syndrome	60.65	9.65	157	162960	37897	110388285
Bradypnoea	60.24	9.65	69	163048	8580	110417602
Hyperthermia malignant	59.59	9.65	48	163069	3852	110422330
Underdose	59.19	9.65	11	163106	63543	110362639
Haematochezia	57.92	9.65	51	163066	115473	110310709
Dyspepsia	57.67	9.65	122	162995	190843	110235339
Arthritis	57.67	9.65	99	163018	167487	110258695
Prescribed underdose	57.14	9.65	13	163104	65161	110361021
Wound infection	56.84	9.65	36	163081	96429	110329753
Tracheal deviation	56.80	9.65	20	163097	278	110425904
Metabolic acidosis	56.73	9.65	294	162823	99450	110326732
Insurance issue	56.62	9.65	74	163043	10538	110415644
Adverse event	55.81	9.65	47	163070	108762	110317420
Deep vein thrombosis postoperative	55.79	9.65	10	163107	59281	110366901
Postmortem blood drug level	55.40	9.65	20	163097	300	110425882
Night sweats	55.02	9.65	70	163047	133913	110292269
Adulterated product	54.91	9.65	29	163088	1126	110425056
Extradural haematoma	54.77	9.65	43	163074	3326	110422856
Trigemino-cardiac reflex	54.71	9.65	22	163095	449	110425733
Product adhesion issue	54.64	9.65	41	163076	2965	110423217
Medication error	54.11	9.65	302	162815	105064	110321118
Nail disorder	54.02	9.65	10	163107	57925	110368257
Red blood cell sedimentation rate increased	53.81	9.65	24	163093	78278	110347904
Pancytopenia	53.71	9.65	146	162971	209467	110216715
Phrenic nerve paralysis	53.30	9.65	23	163094	564	110425618
Myelosuppression	53.17	9.65	37	163080	94303	110331879
Malignant neoplasm progression	53.15	9.65	111	163006	174456	110251726
Pain in extremity	53.12	9.65	461	162656	486657	109939525
Loss of personal independence in daily activities	53.12	9.65	87	163030	149933	110276249
Drug hypersensitivity	53.03	9.65	422	162695	453668	109972514
Colitis ulcerative	52.72	9.65	24	163093	77339	110348843
Haemodynamic instability	52.54	9.65	109	163008	22779	110403403
Anal inflammation	52.07	9.65	37	163080	2459	110423723
Blood ethanol	51.41	9.65	15	163102	108	110426074
Dysarthria	51.39	9.65	253	162864	83868	110342314
Blood cholesterol increased	50.97	9.65	124	162993	184661	110241521
Spinal cord infarction	50.59	9.65	27	163090	1071	110425111
Therapy interrupted	50.36	9.65	175	162942	49647	110376535
Accident	50.28	9.65	71	163046	10881	110415301
Lagophthalmos	50.15	9.65	22	163095	562	110425620
Oedema peripheral	50.12	9.65	282	162835	328378	110097804
Dislocation of vertebra	49.38	9.65	4	163113	43717	110382465
Onychomadesis	49.36	9.65	5	163112	45658	110380524
Extradural abscess	49.13	9.65	33	163084	2001	110424181
Anaemia	49.05	9.65	543	162574	546543	109879639
Opiates positive	48.72	9.65	25	163092	914	110425268
Asthma	48.54	9.65	197	162920	250094	110176088
Drug ineffective for unapproved indication	48.40	9.65	288	162829	102550	110323632
Blood ethanol increased	48.18	9.65	22	163095	619	110425563
Unevaluable event	48.17	9.65	194	162923	59033	110367149
Bone erosion	47.81	9.65	6	163111	46365	110379817
Frequent bowel movements	47.33	9.65	23	163094	71367	110354815
C-reactive protein abnormal	47.06	9.65	74	163043	129621	110296561
Neurotoxicity	46.86	9.65	153	162964	42054	110384128
Removal of foreign body	46.85	9.65	11	163106	28	110426154
Endophthalmitis	46.68	9.65	59	163058	8128	110418054
Drug reaction with eosinophilia and systemic symptoms	46.53	9.65	32	163085	82063	110344119
Infusion site pain	46.04	9.65	88	163029	17331	110408851
Brain stem syndrome	45.59	9.65	27	163090	1312	110424870
SARS-CoV-2 test negative	45.11	9.65	32	163085	2121	110424061
Homicide	44.87	9.65	25	163092	1081	110425101
Infection susceptibility increased	44.82	9.65	43	163074	4355	110421827
Lower limb fracture	44.56	9.65	28	163089	75320	110350862
Amnesia	44.46	9.65	287	162830	105121	110321061
Blepharospasm	44.15	9.65	13	163104	54838	110371344
Paranasal cyst	43.83	9.65	23	163094	881	110425301
Intentional self-injury	43.66	9.65	138	162979	37291	110388891
Cyanosis	43.64	9.65	119	162998	29622	110396560
Coeliac disease	43.54	9.65	6	163111	43181	110383001
Discomfort	43.53	9.65	166	162951	214541	110211641
Prescribed overdose	43.50	9.65	39	163078	87542	110338640
Hypoaesthesia	43.49	9.65	278	162839	313945	110112237
Vascular malformation	43.18	9.65	22	163095	792	110425390
Infection	43.01	9.65	335	162782	361865	110064317
Impaired driving ability	42.99	9.65	50	163067	6320	110419862
Cardiac failure congestive	42.69	9.65	100	163017	150900	110275282
Drug abuser	42.57	9.65	46	163071	5363	110420819
Headache	42.36	9.65	985	162132	881392	109544790
Therapeutic product effect incomplete	42.24	9.65	178	162939	223627	110202555
Wrong product administered	41.62	9.65	65	163052	10895	110415287
Treatment failure	41.11	9.65	240	162877	276994	110149188
Inhibitory drug interaction	40.57	9.65	43	163074	4904	110421278
Nausea	40.27	9.65	1455	161662	1234235	109191947
Product administration interrupted	40.17	9.65	65	163052	11227	110414955
Leukopenia	40.12	9.65	101	163016	148690	110277492
Behavioural addiction	40	9.65	11	163106	62	110426120
Anterior chamber cell	39.96	9.65	24	163093	1197	110424985
Gastrooesophageal reflux disease	39.91	9.65	134	162983	179842	110246340
Infusion site swelling	39.50	9.65	60	163057	9817	110416365
Infusion site bruising	39.33	9.65	37	163080	3657	110422525
X-ray abnormal	39.13	9.65	5	163112	38112	110388070
Systemic toxicity	38.94	9.65	16	163101	346	110425836
Hypopyon	38.77	9.65	25	163092	1415	110424767
Product administration error	38.73	9.65	132	162985	37085	110389097
Haemoglobin decreased	38.68	9.65	212	162905	248515	110177667
Meningitis chemical	38.60	9.65	16	163101	354	110425828
Retinal artery occlusion	38.57	9.65	39	163078	4210	110421972
Amphetamines positive	38.15	9.65	15	163102	288	110425894
Purtscher retinopathy	38.13	9.65	14	163103	221	110425961
Lupus-like syndrome	38.12	9.65	7	163110	40785	110385397
Muscle spasms	38.02	9.65	247	162870	277910	110148272
Type I hypersensitivity	37.93	9.65	47	163070	6346	110419836
Pneumonia	37.90	9.65	994	162123	875720	109550462
Myoclonus	37.88	9.65	121	162996	32877	110393305
Proctalgia	37.70	9.65	69	163048	13153	110413029
Infusion site erythema	37.42	9.65	65	163052	11894	110414288
Hypothermia	37.36	9.65	104	163013	26198	110399984
Retinitis	36.39	9.65	3	163114	32324	110393858
Blood pressure fluctuation	36.35	9.65	34	163083	74790	110351392
Dermatitis contact	36.28	9.65	70	163047	13883	110412299
Paraplegia	35.86	9.65	45	163072	6155	110420027
Aqueous fibrin	35.65	9.65	13	163104	201	110425981
Hip arthroplasty	35.48	9.65	19	163098	55794	110370388
Cough	34.99	9.65	475	162642	461166	109965016
Ophthalmoplegia	34.85	9.65	34	163083	3516	110422666
Foot deformity	34.69	9.65	14	163103	48466	110377716
Accidental exposure to product	34.63	9.65	156	162961	49852	110376330
Injection site reaction	34.07	9.65	49	163068	89021	110337161
Hepatitis	34.00	9.65	50	163067	90004	110336178
Brain death	33.78	9.65	45	163072	6528	110419654
Musculoskeletal pain	33.65	9.65	147	162970	182876	110243306
Blood lactic acid increased	33.60	9.65	73	163044	15748	110410434
Myocardial fibrosis	33.59	9.65	26	163091	1969	110424213
Orthostatic hypotension	33.50	9.65	29	163088	66220	110359962
Lupus vulgaris	33.47	9.65	5	163112	33878	110392304
Blood pressure systolic increased	33.41	9.65	44	163073	82947	110343235
Serotonin syndrome	33.38	9.65	174	162943	58979	110367203
Drug resistance	33.26	9.65	21	163096	56353	110369829
Fear of eating	33.14	9.65	16	163101	512	110425670
Sleep disorder	32.73	9.65	166	162951	198478	110227704
Pupil fixed	32.62	9.65	34	163083	3804	110422378
Alcohol intolerance	32.53	9.65	15	163102	432	110425750
Cytomegalovirus infection	32.51	9.65	20	163097	54424	110371758
Vasoplegia syndrome	32.29	9.65	40	163077	5399	110420783
Muscular weakness	31.78	9.65	225	162892	248243	110177939
Infusion site pruritus	31.63	9.65	38	163079	4970	110421212
Urticaria	31.59	9.65	309	162808	318548	110107634
Agranulocytosis	31.27	9.65	27	163090	61733	110364449
Onychomycosis	31.25	9.65	9	163108	38522	110387660
Areflexia	31.25	9.65	44	163073	6725	110419457
Toxicologic test abnormal	31.08	9.65	21	163096	1286	110424896
Insomnia	31.06	9.65	361	162756	360229	110065953
Tubulointerstitial nephritis	30.97	9.65	21	163096	54263	110371919
Pain	30.92	9.65	1125	161992	953830	109472352
Retinal vasculitis	30.85	9.65	25	163092	2024	110424158
Abdominal pain	30.70	9.65	552	162565	512437	109913745
Analgesic drug level increased	30.08	9.65	33	163084	3913	110422269
Bone marrow failure	29.65	9.65	25	163092	57823	110368359
Tryptase increased	29.48	9.65	18	163099	925	110425257
Coma scale abnormal	29.32	9.65	52	163065	9674	110416508
Infusion site haemorrhage	29.22	9.65	35	163082	4563	110421619
Taste disorder	29.15	9.65	32	163085	65355	110360827
Vitritis	29.07	9.65	27	163090	2626	110423556
Hypoaesthesia oral	29.02	9.65	72	163045	16930	110409252
Glucose tolerance impaired	28.89	9.65	52	163065	9785	110416397
Hypoxic-ischaemic encephalopathy	28.89	9.65	49	163068	8798	110417384
Sciatica	28.76	9.65	58	163059	92341	110333841
Knee arthroplasty	28.72	9.65	32	163085	64916	110361266
Peripheral nerve injury	28.63	9.65	19	163098	1129	110425053
Infusion site extravasation	28.59	9.65	57	163060	11577	110414605
Renal impairment	28.54	9.65	162	162955	188283	110237899
Sensorimotor disorder	28.27	9.65	19	163098	1153	110425029
Appendicolith	28.27	9.65	64	163053	14191	110411991
Pneumocystis jirovecii pneumonia	27.98	9.65	14	163103	42721	110383461
Gastrointestinal toxicity	27.86	9.65	55	163062	11093	110415089
Septic shock	27.48	9.65	129	162988	157399	110268783
Dizziness	27.46	9.65	802	162315	697391	109728791
Postoperative delirium	27.42	9.65	17	163100	898	110425284
Analgesic therapy	27.38	9.65	43	163074	7241	110418941
Cardiotoxicity	27.26	9.65	70	163047	16811	110409371
Liver injury	26.93	9.65	122	162995	150291	110275891
C-reactive protein	26.69	9.65	6	163111	30325	110395857
Hypercalcaemia	26.69	9.65	18	163099	46639	110379543
Spinal epidural haemorrhage	26.67	9.65	12	163105	326	110425856
Anxiety	26.64	9.65	682	162435	344396	110081786
Pneumonia aspiration	26.57	9.65	208	162909	81025	110345157
Surgery	26.53	9.65	126	162991	41157	110385025
Product use issue	26.47	9.65	313	162804	311382	110114800
Multiple organ dysfunction syndrome	26.46	9.65	341	162776	151369	110274813
Drug therapy	25.98	9.65	42	163075	7249	110418933
Oculocardiac reflex	25.76	9.65	9	163108	122	110426060
Gait disturbance	25.74	9.65	274	162843	277934	110148248
Disease recurrence	25.74	9.65	31	163086	60753	110365429
Mastoiditis	25.62	9.65	25	163092	2586	110423596
Epilepsy	25.51	9.65	70	163047	100139	110326043
Hyperphosphataemia	25.50	9.65	67	163050	16314	110409868
Premature delivery	25.44	9.65	101	163016	30531	110395651
Respiratory tract infection bacterial	25.34	9.65	24	163093	2392	110423790
Postmortem blood drug level increased	25.29	9.65	18	163099	1199	110424983
Stress	25.26	9.65	252	162865	105096	110321086
Chemical burn	25.25	9.65	15	163102	733	110425449
Laboratory test abnormal	25.22	9.65	17	163100	44062	110382120
Sleep disorder therapy	25.22	9.65	42	163075	7429	110418753
Delirium tremens	25.20	9.65	15	163102	736	110425446
Pneumocephalus	25.09	9.65	13	163104	485	110425697
Corneal epithelium defect	24.96	9.65	16	163101	896	110425286
Back injury	24.89	9.65	20	163097	47379	110378803
Anal sphincter atony	24.68	9.65	13	163104	502	110425680
Dry mouth	24.63	9.65	183	162934	199765	110226417
Paralysis	24.49	9.65	64	163053	15536	110410646
Somnambulism	24.34	9.65	38	163079	6367	110419815
Abnormal behaviour	24.26	9.65	118	162999	38921	110387261
Rectal haemorrhage	24.05	9.65	93	163024	119740	110306442
Psychomotor hyperactivity	23.87	9.65	75	163042	20202	110405980
Anaphylactoid shock	23.82	9.65	16	163101	970	110425212
Spinal epidural haematoma	23.78	9.65	20	163097	1705	110424477
Paraesthesia	23.74	9.65	277	162840	276244	110149938
Macular ischaemia	23.73	9.65	10	163107	231	110425951
Blood phosphorus increased	23.60	9.65	65	163052	16275	110409907
Stridor	23.59	9.65	39	163078	6856	110419326
Full blood count abnormal	23.30	9.65	29	163088	56023	110370159
Dehydration	23.23	9.65	282	162835	279229	110146953
Delayed recovery from anaesthesia	23.23	9.65	22	163095	2193	110423989
Migraine	23.15	9.65	153	162964	171499	110254683
Protein C increased	23.03	9.65	7	163110	59	110426123
Breast cancer stage II	22.94	9.65	6	163111	27369	110398813
Osteoporosis	22.85	9.65	60	163057	87092	110339090
Chest pain	22.82	9.65	404	162713	375971	110050211
Neuromuscular blockade	22.74	9.65	14	163103	730	110425452
Hyperaesthesia	22.69	9.65	60	163057	14667	110411515
Myocardial infarction	22.62	9.65	178	162939	191905	110234277
Metastases to liver	22.56	9.65	12	163105	35374	110390808
Melaena	22.40	9.65	42	163075	68715	110357467
Spinal anaesthesia	22.35	9.65	8	163109	117	110426065
Poor quality sleep	22.06	9.65	91	163026	27986	110398196
Tremor	22.06	9.65	420	162697	201812	110224370
Hyperlipidaemia	22.02	9.65	108	163009	35740	110390442
Vocal cord dysfunction	21.96	9.65	15	163102	935	110425247
Arthritis bacterial	21.93	9.65	49	163068	10771	110415411
Brain injury	21.89	9.65	56	163061	13420	110412762
Infusion site mass	21.72	9.65	19	163098	1709	110424473
Platelet aggregation inhibition	21.63	9.65	9	163108	201	110425981
Kidney congestion	21.58	9.65	12	163105	517	110425665
Trigeminal palsy	21.53	9.65	7	163110	75	110426107
Epidural haemorrhage	21.44	9.65	11	163106	402	110425780
Bundle branch block left	21.39	9.65	54	163063	12834	110413348
Congestive hepatopathy	21.29	9.65	32	163085	5188	110420994
Respiratory distress	21.24	9.65	174	162943	68700	110357482
Negative pressure pulmonary oedema	20.98	9.65	13	163104	686	110425496
Substance use	20.94	9.65	22	163095	2484	110423698
Diabetes insipidus	20.94	9.65	36	163081	6534	110419648
Prostate cancer	20.89	9.65	15	163102	37626	110388556
Peritonitis	20.87	9.65	11	163106	32596	110393586
Haemorrhoids	20.87	9.65	106	163011	35566	110390616
Gastroenteritis	20.84	9.65	16	163101	38784	110387398
Medical device site cellulitis	20.81	9.65	9	163108	222	110425960
Ventricular arrhythmia	20.80	9.65	46	163071	10041	110416141
Ventricular extrasystoles	20.73	9.65	77	163040	22564	110403618
Post procedural complication	20.63	9.65	86	163031	26572	110399610
Gastrointestinal haemorrhage	20.62	9.65	151	162966	165367	110260815
Alcoholic coma	20.52	9.65	7	163110	88	110426094
Neuromuscular block prolonged	20.45	9.65	16	163101	1231	110424951
Hyperkalaemia	20.42	9.65	117	163000	135679	110290503
Bursitis infective	20.12	9.65	17	163100	1459	110424723
Therapy cessation	20.07	9.65	124	162993	44733	110381449
Incorrect drug administration rate	19.99	9.65	32	163085	5476	110420706
Torsade de pointes	19.98	9.65	76	163041	22524	110403658
Substance abuser	19.95	9.65	11	163106	466	110425716
Exostosis	19.93	9.65	23	163094	45933	110380249
Pupillary reflex impaired	19.89	9.65	27	163090	3988	110422194
Epidural analgesia	19.82	9.65	8	163109	165	110426017
Seasonal allergy	19.69	9.65	69	163048	19653	110406529
Mean arterial pressure decreased	19.65	9.65	11	163106	480	110425702
Cholestasis	19.65	9.65	41	163076	64477	110361705
Drug tolerance decreased	19.63	9.65	8	163109	27532	110398650
White blood cell count decreased	19.60	9.65	230	162887	229160	110197022
Anaesthetic complication pulmonary	19.60	9.65	8	163109	170	110426012
Myasthenia gravis	19.56	9.65	73	163044	21438	110404744
Product preparation error	19.56	9.65	47	163070	10832	110415350
Procedure aborted	19.47	9.65	8	163109	173	110426009
Airway peak pressure increased	19.37	9.65	12	163105	633	110425549
Oedema	19.34	9.65	207	162910	209769	110216413
Accidental poisoning	19.31	9.65	21	163096	2466	110423716
Hypertonia	19.25	9.65	40	163077	8366	110417816
Acute pulmonary oedema	19.22	9.65	62	163055	16934	110409248
Hypoventilation	19.15	9.65	39	163078	8042	110418140
Diabetes mellitus inadequate control	19.12	9.65	10	163107	29765	110396417
Upper airway obstruction	19.09	9.65	18	163099	1784	110424398
Central pain syndrome	19.08	9.65	13	163104	807	110425375
Encephalopathy	19.00	9.65	193	162924	80862	110345320
Glossoptosis	19.00	9.65	9	163108	276	110425906
Adjustment disorder with depressed mood	18.99	9.65	22	163095	43861	110382321
Haematotoxicity	18.90	9.65	4	163113	21078	110405104
Alcoholic pancreatitis	18.89	9.65	8	163109	187	110425995
Product prescribing error	18.89	9.65	29	163088	51302	110374880
Foetal heart rate abnormal	18.87	9.65	12	163105	663	110425519
Multiple sclerosis relapse	18.86	9.65	28	163089	50212	110375970
Otitis media	18.82	9.65	37	163080	7439	110418743
Pulmonary congestion	18.81	9.65	93	163024	30873	110395309
Ventricular tachyarrhythmia	18.81	9.65	11	163106	522	110425660
Autoimmune disorder	18.80	9.65	43	163074	65440	110360742
Punctate keratitis	18.78	9.65	15	163102	1189	110424993
Parophthalmia	18.75	9.65	11	163106	525	110425657
Infusion site urticaria	18.65	9.65	15	163102	1201	110424981
Finger deformity	18.62	9.65	13	163104	33079	110393103
Anticholinergic syndrome	18.55	9.65	27	163090	4253	110421929
Thrombotic microangiopathy	18.41	9.65	10	163107	29139	110397043
Piloerection	18.40	9.65	13	163104	856	110425326
Medical device site abscess	18.32	9.65	8	163109	202	110425980
Nerve root injury	18.31	9.65	6	163111	66	110426116
Diabetic ketoacidosis	18.29	9.65	21	163096	42037	110384145
Liver function test increased	18.24	9.65	68	163049	88480	110337702
Bezoar	18.19	9.65	26	163091	4028	110422154
Progressive multifocal leukoencephalopathy	18.19	9.65	7	163110	24949	110401233
Drug eruption	18.18	9.65	32	163085	53627	110372555
Lung neoplasm malignant	18.12	9.65	14	163103	33828	110392354
Substance dependence	18.08	9.65	12	163105	713	110425469
Porphyria acute	18.03	9.65	3	163114	18777	110407405
Bladder cancer	17.88	9.65	4	163113	20288	110405894
Spinal meningeal cyst	17.87	9.65	7	163110	133	110426049
Tracheitis	17.87	9.65	17	163100	1704	110424478
Product contamination microbial	17.86	9.65	14	163103	1080	110425102
Osteonecrosis of jaw	17.79	9.65	27	163090	47990	110378192
Upper gastrointestinal haemorrhage	17.77	9.65	29	163088	50067	110376115
Inadequate analgesia	17.75	9.65	29	163088	5048	110421134
Deep vein thrombosis	17.72	9.65	127	162990	139760	110286422
Acute hepatic failure	17.71	9.65	103	163014	36365	110389817
Infusion site discharge	17.71	9.65	18	163099	1955	110424227
Bone density decreased	17.67	9.65	58	163059	15984	110410198
Intellectual disability	17.66	9.65	18	163099	1961	110424221
Brachial plexus injury	17.63	9.65	7	163110	138	110426044
Visceral oedema	17.62	9.65	6	163111	75	110426107
Staphylococcal infection	17.59	9.65	169	162948	69775	110356407
Laryngitis	17.57	9.65	22	163095	42389	110383793
Illness	17.55	9.65	192	162925	81979	110344203
Disorientation	17.40	9.65	170	162947	70501	110355681
Incorrect product formulation administered	17.36	9.65	8	163109	230	110425952
Abortion spontaneous	17.34	9.65	15	163102	34267	110391915
Immunodeficiency	17.32	9.65	19	163098	38819	110387363
Retrograde amnesia	17.19	9.65	12	163105	775	110425407
Incoherent	17.11	9.65	38	163079	8320	110417862
Substance-induced mood disorder	17.07	9.65	6	163111	83	110426099
Jaundice	16.92	9.65	39	163078	59197	110366985
Psychiatric disorder prophylaxis	16.90	9.65	5	163112	38	110426144
Apnoeic attack	16.85	9.65	12	163105	800	110425382
Induced abortion failed	16.84	9.65	7	163110	156	110426026
Physical assault	16.75	9.65	16	163101	1612	110424570
Walking aid user	16.74	9.65	8	163109	25067	110401115
Atonic urinary bladder	16.72	9.65	7	163110	159	110426023
Aspiration	16.67	9.65	89	163028	30444	110395738
Vasculitis	16.61	9.65	17	163100	35856	110390326
Dry skin	16.59	9.65	92	163025	107561	110318621
Eczema	16.59	9.65	53	163064	72240	110353942
Food interaction	16.41	9.65	18	163099	2134	110424048
Quadriplegia	16.41	9.65	25	163092	4102	110422080
Sexual abuse	16.34	9.65	8	163109	264	110425918
Pancreatitis acute	16.18	9.65	41	163076	60233	110365949
Postictal state	16.17	9.65	19	163098	2427	110423755
Acidosis	16.14	9.65	71	163046	22460	110403722
Creatinine renal clearance decreased	16.10	9.65	6	163111	21809	110404373
Foreign body in respiratory tract	16.09	9.65	9	163108	392	110425790
Depression	16.08	9.65	351	162766	316984	110109198
Colitis	16.01	9.65	87	163030	102236	110323946
Injection site ulcer	15.99	9.65	12	163105	868	110425314
Uveitis	15.98	9.65	6	163111	21704	110404478
Multiple injuries	15.96	9.65	23	163094	3591	110422591
Pregnancy	15.94	9.65	32	163085	51035	110375147
Painful ejaculation	15.88	9.65	6	163111	103	110426079
Eosinophilia	15.87	9.65	39	163078	57897	110368285
Memory impairment	15.86	9.65	200	162917	196744	110229438
Axillary nerve injury	15.78	9.65	5	163112	49	110426133
Blood creatinine increased	15.77	9.65	183	162934	182706	110243476
Oxygen saturation decreased	15.76	9.65	322	162795	156660	110269522
Therapy partial responder	15.68	9.65	101	163016	36960	110389222
Maternal alcohol use	15.67	9.65	4	163113	16	110426166
Intelligence test abnormal	15.67	9.65	4	163113	16	110426166
Hypophosphataemia	15.65	9.65	93	163024	33089	110393093
Prostatic pain	15.63	9.65	8	163109	291	110425891
Drowning	15.55	9.65	12	163105	905	110425277
Ventricular asystole	15.53	9.65	9	163108	420	110425762
Electrocution	15.48	9.65	4	163113	17	110426165
Lymphopenia	15.46	9.65	22	163095	40148	110386034
Blood pH decreased	15.43	9.65	26	163091	4643	110421539
Fluid retention	15.42	9.65	79	163038	94228	110331954
Confusional state	15.37	9.65	551	162566	468129	109958053
Hyporesponsive to stimuli	15.35	9.65	20	163097	2840	110423342
Gastritis alcoholic	15.29	9.65	4	163113	18	110426164
Mean arterial pressure increased	15.27	9.65	6	163111	115	110426067
Pemphigoid	15.27	9.65	5	163112	19702	110406480
Administration related reaction	15.23	9.65	8	163109	307	110425875
Neuropathy peripheral	15.22	9.65	180	162937	179097	110247085
Brugada syndrome	15.20	9.65	15	163102	1573	110424609
Nasal congestion	15.14	9.65	84	163033	98198	110327984
Sleep disorder due to a general medical condition	15.14	9.65	34	163083	52078	110374104
Suicidal behaviour	15.07	9.65	22	163095	3475	110422707
Myelodysplastic syndrome	14.96	9.65	20	163097	37464	110388718
Brachial artery entrapment syndrome	14.94	9.65	5	163112	59	110426123
Labelled drug-food interaction issue	14.90	9.65	6	163111	123	110426059
Neuroleptic malignant syndrome	14.82	9.65	17	163100	34042	110392140
Procedural complication	14.78	9.65	36	163081	8369	110417813
Intracranial hypotension	14.58	9.65	10	163107	628	110425554
Potentiating drug interaction	14.57	9.65	44	163073	11599	110414583
Seizure like phenomena	14.57	9.65	18	163099	2423	110423759
Brain herniation	14.57	9.65	37	163080	8826	110417356
Lethargy	14.53	9.65	206	162911	93370	110332812
Open globe injury	14.50	9.65	7	163110	224	110425958
Foetal death	14.47	9.65	3	163114	16042	110410140
Cerebral congestion	14.47	9.65	7	163110	225	110425957
Visual acuity reduced	14.43	9.65	89	163028	32084	110394098
Consciousness fluctuating	14.42	9.65	17	163100	2179	110424003
Conjunctival scar	14.40	9.65	8	163109	344	110425838
Cardiac death	14.37	9.65	15	163102	1681	110424501
Alcoholic	14.33	9.65	4	163113	24	110426158
Benzodiazepine drug level therapeutic	14.33	9.65	4	163113	24	110426158
Constipation	14.28	9.65	410	162707	357376	110068806
Injection site atrophy	14.27	9.65	9	163108	490	110425692
Cytopenia	14.26	9.65	14	163103	30102	110396080
Spinal operation	14.24	9.65	42	163075	10930	110415252
Chronic kidney disease	14.18	9.65	61	163056	76230	110349952
Graft versus host disease	14.17	9.65	5	163112	18801	110407381
Gastric disorder	14.14	9.65	17	163100	33340	110392842
Anterior chamber fibrin	13.97	9.65	7	163110	243	110425939
Hepatocellular injury	13.94	9.65	34	163083	50608	110375574
Injection site joint infection	13.91	9.65	5	163112	74	110426108
Device expulsion	13.90	9.65	15	163102	30876	110395306
Environmental exposure	13.75	9.65	8	163109	376	110425806
Nail bed tenderness	13.75	9.65	8	163109	376	110425806
Adverse reaction	13.73	9.65	14	163103	29580	110396602
Ventricular hypokinesia	13.68	9.65	42	163075	11172	110415010
Ear pain	13.68	9.65	37	163080	53189	110372993
Blood pressure systolic abnormal	13.67	9.65	10	163107	24840	110401342
Maternal exposure timing unspecified	13.58	9.65	7	163110	21006	110405176
Left ventricle outflow tract obstruction	13.57	9.65	9	163108	534	110425648
Sinus bradycardia	13.50	9.65	82	163035	29401	110396781
Educational problem	13.50	9.65	9	163108	539	110425643
Skin exfoliation	13.45	9.65	75	163042	87576	110338606
Blood pressure diastolic abnormal	13.42	9.65	11	163106	25804	110400378
Palmar-plantar erythrodysaesthesia syndrome	13.42	9.65	25	163092	41000	110385182
Hepatic function abnormal	13.39	9.65	77	163040	89218	110336964
Angina pectoris	13.38	9.65	47	163070	62248	110363934
Infusion site discomfort	13.38	9.65	15	163102	1822	110424360
Hypoproteinaemia	13.28	9.65	28	163089	5917	110420265
Nerve root injury cervical	13.28	9.65	3	163114	6	110426176
Hallucination, visual	13.27	9.65	102	163015	39503	110386679
Anal skin tags	13.25	9.65	9	163108	556	110425626
Blood pressure decreased	13.23	9.65	241	162876	114850	110311332
Foreign body	13.14	9.65	19	163098	2976	110423206
Long QT syndrome congenital	13.14	9.65	6	163111	169	110426013
Neuralgia	13.13	9.65	119	162998	48359	110377823
Metastases to lung	13.05	9.65	9	163108	23054	110403128
Logorrhoea	13.05	9.65	25	163092	4932	110421250
Patient uncooperative	12.97	9.65	11	163106	949	110425233
Infusion site irritation	12.95	9.65	12	163105	1163	110425019
Accelerated idioventricular rhythm	12.95	9.65	7	163110	285	110425897
Full blood count decreased	12.94	9.65	17	163100	32082	110394100
Coronary artery disease	12.92	9.65	58	163059	71632	110354550
International normalised ratio increased	12.91	9.65	75	163042	86697	110339485
Spinal cord compression	12.91	9.65	32	163085	7520	110418662
End-tidal CO2 decreased	12.86	9.65	5	163112	93	110426089
Syphilis	12.84	9.65	10	163107	764	110425418
Application site alopecia	12.83	9.65	4	163113	37	110426145
Spinal cord injury	12.82	9.65	14	163103	1651	110424531
Eyelid ptosis	12.77	9.65	46	163071	13281	110412901
Device effect incomplete	12.73	9.65	4	163113	38	110426144
Incision site rash	12.73	9.65	4	163113	38	110426144
Catecholamine crisis	12.72	9.65	5	163112	96	110426086
Opisthotonus	12.71	9.65	10	163107	776	110425406
Enterobacter pneumonia	12.69	9.65	9	163108	596	110425586
Dose calculation error	12.66	9.65	8	163109	437	110425745
Euphoric mood	12.63	9.65	35	163082	8792	110417390
Lip haemorrhage	12.59	9.65	13	163104	1439	110424743
Proteinuria	12.55	9.65	25	163092	39993	110386189
Supraventricular extrasystoles	12.55	9.65	33	163084	8040	110418142
Hypothyroidism	12.53	9.65	60	163057	72839	110353343
Reperfusion arrhythmia	12.47	9.65	7	163110	307	110425875
Cardiac failure	12.47	9.65	198	162919	187428	110238754
Inflammatory marker increased	12.46	9.65	3	163114	14466	110411716
Non-cardiogenic pulmonary oedema	12.44	9.65	15	163102	1969	110424213
Self-medication	12.38	9.65	28	163089	6204	110419978
Diffuse large B-cell lymphoma	12.38	9.65	4	163113	15894	110410288
Economic problem	12.34	9.65	22	163095	4109	110422073
Palpitations	12.33	9.65	163	162954	159049	110267133
Multiple allergies	12.33	9.65	43	163074	12220	110413962
Iron deficiency	12.32	9.65	57	163060	18419	110407763
Eyelid contusion	12.30	9.65	5	163112	105	110426077
Respiratory rate decreased	12.30	9.65	28	163089	6230	110419952
Air embolism	12.24	9.65	9	163108	631	110425551
Encephalomalacia	12.22	9.65	13	163104	1489	110424693
Spinal cord oedema	12.14	9.65	8	163109	470	110425712
Fall	12.07	9.65	748	162369	602734	109823448
Exposure via ingestion	12.03	9.65	24	163093	4876	110421306
Drug-induced liver injury	12.03	9.65	116	163001	119951	110306231
Transient ischaemic attack	11.99	9.65	51	163066	63931	110362251
Vitamin D increased	11.99	9.65	10	163107	843	110425339
Implant site bruising	11.97	9.65	7	163110	332	110425850
Hanging	11.96	9.65	6	163111	209	110425973
Vaginal abscess	11.91	9.65	8	163109	485	110425697
Fatty liver alcoholic	11.89	9.65	4	163113	48	110426134
Mucosal inflammation	11.83	9.65	88	163029	96053	110330129
Neoplasm progression	11.79	9.65	52	163065	64543	110361639
Airway complication of anaesthesia	11.70	9.65	9	163108	675	110425507
Laryngospasm	11.63	9.65	23	163094	4645	110421537
Blood pressure diastolic decreased	11.62	9.65	22	163095	35863	110390319
Familial periodic paralysis	11.60	9.65	7	163110	352	110425830
Gun shot wound	11.57	9.65	11	163106	1101	110425081
Contusion	11.57	9.65	259	162858	233102	110193080
Blood pressure immeasurable	11.56	9.65	16	163101	2407	110423775
Repetitive strain injury	11.53	9.65	6	163111	226	110425956
Suspected suicide attempt	11.51	9.65	7	163110	357	110425825
Rash erythematous	11.51	9.65	72	163045	81760	110344422
Abnormal sleep-related event	11.46	9.65	10	163107	896	110425286
Acute respiratory failure	11.41	9.65	165	162952	75095	110351087
Ependymoma	11.39	9.65	5	163112	128	110426054
Eclampsia	11.37	9.65	7	163110	365	110425817
Myopathy	11.37	9.65	12	163105	24948	110401234
Cytomegalovirus viraemia	11.36	9.65	6	163111	17758	110408424
Drug diversion	11.33	9.65	12	163105	1368	110424814
Pulmonary toxicity	11.28	9.65	54	163063	17692	110408490
Heliotrope rash	11.24	9.65	6	163111	238	110425944
Spinal cord ischaemia	11.24	9.65	6	163111	238	110425944
Pancreatic carcinoma	11.13	9.65	4	163113	14868	110411314
Tenderness	11.12	9.65	78	163039	29359	110396823
Drug-disease interaction	11.11	9.65	14	163103	1922	110424260
Appendicitis	11.09	9.65	76	163041	28388	110397794
Dyspnoea exertional	11.09	9.65	99	163018	103961	110322221
Vitreous disorder	11.05	9.65	7	163110	384	110425798
Epstein-Barr virus infection	11.03	9.65	7	163110	18731	110407451
Impaired quality of life	11.02	9.65	79	163038	29938	110396244
Febrile bone marrow aplasia	11.02	9.65	6	163111	17459	110408723
Visual impairment	11.02	9.65	136	162981	134292	110291890
Transplant rejection	10.98	9.65	12	163105	24555	110401627
Oxidative stress	10.96	9.65	4	163113	62	110426120
Acute myeloid leukaemia	10.96	9.65	25	163092	38085	110388097
Hypertension	10.94	9.65	628	162489	509456	109916726
Aspergillus infection	10.92	9.65	13	163104	25603	110400579
Foetal heart rate decreased	10.90	9.65	4	163113	63	110426119
Imprisonment	10.88	9.65	9	163108	750	110425432
Intestinal obstruction	10.88	9.65	41	163076	53186	110372996
Spinal stroke	10.84	9.65	4	163113	64	110426118
Tachypnoea	10.82	9.65	97	163020	39298	110386884
Vascular resistance systemic decreased	10.76	9.65	6	163111	260	110425922
Inappropriate antidiuretic hormone secretion	10.74	9.65	21	163096	33830	110392352
Anaphylactoid reaction	10.71	9.65	28	163089	6798	110419384
Allergy to immunoglobulin therapy	10.69	9.65	5	163112	149	110426033
Vascular stenosis	10.68	9.65	9	163108	769	110425413
Bacteroides infection	10.65	9.65	17	163100	2902	110423280
Harlequin syndrome	10.65	9.65	6	163111	265	110425917
Myokymia	10.62	9.65	5	163112	151	110426031
Infusion site streaking	10.62	9.65	8	163109	582	110425600
Hepatic fibrosis	10.59	9.65	31	163086	8035	110418147
Hepatitis C virus test positive	10.58	9.65	7	163110	414	110425768
Nerve block	10.57	9.65	9	163108	780	110425402
Femoral nerve injury	10.57	9.65	4	163113	69	110426113
Poor quality product administered	10.53	9.65	22	163095	4619	110421563
Basal cell carcinoma	10.52	9.65	33	163084	45237	110380945
Platelet count decreased	10.52	9.65	259	162858	230184	110195998
Blood methaemoglobin present	10.50	9.65	5	163112	155	110426027
Blood glucose increased	10.50	9.65	135	162982	132361	110293821
Hallucination, tactile	10.49	9.65	10	163107	1005	110425177
Corneal opacity	10.48	9.65	11	163106	1240	110424942
Infusion site rash	10.48	9.65	15	163102	2328	110423854
Respiratory tract infection	10.46	9.65	156	162961	71461	110354721
Feeling hot	10.46	9.65	85	163032	91021	110335161
Chronic sinusitis	10.40	9.65	13	163104	25071	110401111
Temperature regulation disorder	10.39	9.65	3	163114	12823	110413359
Cholestasis of pregnancy	10.38	9.65	11	163106	1254	110424928
Body dysmorphic disorder	10.37	9.65	7	163110	428	110425754
Metastases to bone	10.36	9.65	19	163098	31353	110394829
Panniculitis	10.36	9.65	5	163112	15577	110410605
Dextrocardia	10.35	9.65	3	163114	21	110426161
Syringomyelia	10.35	9.65	6	163111	280	110425902
Middle insomnia	10.33	9.65	9	163108	20493	110405689
Macular degeneration	10.33	9.65	10	163107	21649	110404533
Product distribution issue	10.33	9.65	21	163096	4325	110421857
Second primary malignancy	10.29	9.65	7	163110	18061	110408121
Abdominal pain lower	10.29	9.65	25	163092	37258	110388924
Nervous system disorder	10.25	9.65	81	163036	31640	110394542
Administration site pain	10.17	9.65	9	163108	822	110425360
Injection site bruising	10.15	9.65	40	163077	51223	110374959
Respiratory tract infection viral	10.15	9.65	25	163092	5853	110420329
Arterial injury	10.14	9.65	9	163108	825	110425357
Injection site inflammation	10.11	9.65	22	163095	4749	110421433
Distributive shock	10.07	9.65	25	163092	5879	110420303
Irregular breathing	10.03	9.65	8	163109	633	110425549
Sensory loss	10.03	9.65	60	163057	21397	110404785
Lymphoma	9.99	9.65	9	163108	20162	110406020
Tuberculosis	9.97	9.65	7	163110	17767	110408415
Neoplasm malignant	9.97	9.65	91	163026	37052	110389130
Enterocolitis	9.94	9.65	8	163109	18941	110407241
Amaurosis	9.94	9.65	12	163105	1577	110424605
Intentional dose omission	9.94	9.65	57	163060	20023	110406159
Stab wound	9.90	9.65	6	163111	304	110425878
Hypogammaglobulinaemia	9.89	9.65	9	163108	20067	110406115
Procedural anxiety	9.89	9.65	9	163108	852	110425330
Chemical poisoning	9.89	9.65	5	163112	177	110426005
Anal ulcer	9.88	9.65	13	163104	1863	110424319
Angina unstable	9.86	9.65	6	163111	16426	110409756
Photosensitivity reaction	9.86	9.65	14	163103	25575	110400607
Hepatitis alcoholic	9.86	9.65	8	163109	649	110425533
Attention deficit hyperactivity disorder	9.86	9.65	21	163096	4470	110421712
Premature baby	9.85	9.65	22	163095	4833	110421349
Nasal mucosal disorder	9.84	9.65	13	163104	1870	110424312
Neutropenic sepsis	9.82	9.65	19	163098	30727	110395455
Nasal flaring	9.80	9.65	4	163113	85	110426097
Oxygen therapy	9.79	9.65	20	163097	4133	110422049
Toxic leukoencephalopathy	9.77	9.65	12	163105	1605	110424577
Skin lesion	9.77	9.65	41	163076	51590	110374592
Orbital infection	9.71	9.65	5	163112	184	110425998
Pulmonary haemorrhage	9.70	9.65	49	163068	16407	110409775
Infusion site inflammation	9.68	9.65	7	163110	478	110425704
Haemophagocytic lymphohistiocytosis	9.66	9.65	20	163097	31539	110394643

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	35.96	34.40	10	73	139	113731

Pharmacologic Action:

Source	Code	Description
ATC	D08AJ01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds
ATC	D09AA05	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	D09AA11	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	R02AA16	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
CHEBI has role	CHEBI:27780	detergent
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35195	surfactant
CHEBI has role	CHEBI:48218	antiseptic drug
CHEBI has role	CHEBI:48219	disinfectant
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D003902	Detergents
MeSH PA	D010592	Pharmaceutic Aids
MeSH PA	D011310	Preservatives, Pharmaceutical
MeSH PA	D013501	Surface-Active Agents

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R02AA Antiseptics 15 drugs

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Uveitis	indication	128473001	DOID:13141
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Allergic otitis externa	indication	405821001
Itching of skin	indication	418363000
Itching of ear	indication	699392007
Post-Op Ocular Inflammation	indication
Suppression of the Gag Reflex	indication
Mouth Irritation	indication
Prevent Minor Bacterial Skin Infection	indication
Minor Skin Wound Pain	indication
Bacterial septicemia	contraindication	10001005	DOID:0040085
Hypocupremia	contraindication	19577007
Infection of skin AND/OR subcutaneous tissue	contraindication	19824006
Shock	contraindication	27942005
Methemoglobinemia	contraindication	38959009	DOID:10783
Conduction disorder of the heart	contraindication	44808001
Perforation of tympanic membrane	contraindication	60442001
Diabetes mellitus	contraindication	73211009	DOID:9351
Decreased respiratory function	contraindication	80954004
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Deficiency of cytochrome-b>5< reductase	contraindication	124184009
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Heart block	contraindication	233916004
Disease of liver	contraindication	235856003	DOID:409
Condyloma acuminatum	contraindication	240542006	DOID:11168
Peripheral vascular disease	contraindication	400047006
Blister	contraindication	417237009
Denuded skin	contraindication	418242004
Inflammatory dermatosis	contraindication	703938007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018249	VUID
N0000178890	NUI
D00857	KEGG_DRUG
8001-54-5	SECONDARY_CAS_RN
4018249	VANDF
4023321	VANDF
C0005025	UMLSCUI
CHEBI:188978	CHEBI
CHEMBL1187417	ChEMBL_ID
CHEMBL502109	ChEMBL_ID
CHEMBL1907001	ChEMBL_ID
DB11105	DRUGBANK_ID
7N6JUD5X6Y	UNII
2330	PUBCHEM_CID
DB13282	DRUGBANK_ID
1311593	RXNORM
4255	MMSL
5003	MMSL
003141	NDDF
005466	NDDF
006369	NDDF
373549009	SNOMEDCT_US
64686009	SNOMEDCT_US
735078001	SNOMEDCT_US
90370005	SNOMEDCT_US
D001548	MESH_DESCRIPTOR_UI
1168	INN_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
HurriCaine One	HUMAN OTC DRUG LABEL	2	0283-1024	SPRAY	1.30 mg	TOPICAL	OTC Monograph Drug	12 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-0242	SOAP	130 mg	TOPICAL	OTC Monograph Drug	12 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-0242	SOAP	130 mg	TOPICAL	OTC Monograph Drug	12 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	1.30 mg	TOPICAL	OTC monograph not final	10 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	1.30 mg	TOPICAL	OTC monograph not final	10 sections
Nicefresh scent	HUMAN OTC DRUG LABEL	1	0363-0554	CLOTH	0.12 g	TOPICAL	OTC monograph not final	11 sections
4x Medicated Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	0363-0607	CREAM	0.13 g	ORAL	OTC Monograph Drug	10 sections
PM Toothache Relief	HUMAN OTC DRUG LABEL	4	0363-1623	PASTE	0.13 g	DENTAL	OTC Monograph Drug	8 sections
Antibacterial Lidocaine Wound Gel	HUMAN OTC DRUG LABEL	2	0363-1652	GEL	0.13 g	TOPICAL	OTC Monograph Drug	12 sections
Antibacterial Lidocaine Wound Gel	HUMAN OTC DRUG LABEL	2	0363-1652	GEL	0.13 g	TOPICAL	OTC Monograph Drug	12 sections
First Aid AntisepticWell at Walgreens	HUMAN OTC DRUG LABEL	2	0363-3286	SPRAY	0.13 g	TOPICAL	OTC monograph not final	11 sections
Walgreens Antibacterial Hand Wipes	HUMAN OTC DRUG LABEL	1	0363-5189	CLOTH	0.11 g	TOPICAL	OTC Monograph Drug	9 sections
Walgreens Fresh Scent Antibacterial Hand Wipes	HUMAN OTC DRUG LABEL	1	0363-5197	CLOTH	0.11 g	TOPICAL	OTC Monograph Drug	9 sections
4x Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	4	0363-6008	GEL	0.13 g	ORAL	OTC Monograph Drug	9 sections
Walgreen Maximum strength pain relieving cleansing	HUMAN OTC DRUG LABEL	2	0363-7020	LIQUID	0.13 g	TOPICAL	OTC Monograph Drug	14 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	0363-7110	LIQUID	1.25 g	TOPICAL	OTC monograph not final	11 sections
STUDIO 35 BEAUTYAMBER ANTIBACTERIAL REFILL	HUMAN OTC DRUG LABEL	1	0363-7210	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens ANTIBACTERIAL HAND REFILL	HUMAN OTC DRUG LABEL	1	0363-7211	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
STUDIO 35AMBER	HUMAN OTC DRUG LABEL	1	0363-7215	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Antiseptic Pain Relieving	HUMAN OTC DRUG LABEL	2	0363-7779	SPRAY	0.10 g	TOPICAL	OTC monograph not final	7 sections
Walgreens	HUMAN OTC DRUG LABEL	2	0363-7950	SPRAY	0.13 g	TOPICAL	OTC Monograph Drug	12 sections
Walgreens Fresh Antibacterial Foaming Hand	HUMAN OTC DRUG LABEL	1	0363-9000	SOAP	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens Citrus Antibacterial Foaming Hand	HUMAN OTC DRUG LABEL	1	0363-9002	SOAP	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens Max Strength Burn Gel	HUMAN OTC DRUG LABEL	2	0363-9654	GEL	13 mg	TOPICAL	OTC Monograph Drug	13 sections
Walgreens Advanced Wound Wash	HUMAN OTC DRUG LABEL	1	0363-9656	LIQUID	1.30 mg	TOPICAL	OTC Monograph Drug	12 sections
HUMCO Merthiolate	HUMAN OTC DRUG LABEL	1	0395-8010	LIQUID	1.30 mg	TOPICAL	OTC Monograph Drug	13 sections
Merthiolate	HUMAN OTC DRUG LABEL	1	0395-9122	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0404-4445	LIQUID	7.49 g	TOPICAL	OTC monograph not final	11 sections
BZK Towelette	HUMAN OTC DRUG LABEL	1	0404-5824	SWAB	0.00 mL	TOPICAL	OTC monograph not final	8 sections
BZK	HUMAN OTC DRUG LABEL	1	0404-6735	LIQUID	0.00 g	TOPICAL	OTC Monograph Drug	12 sections