All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

benzalkonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3017	139-07-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzalkonium chloride benzalkonium benzyldodecyldimethylammonium chloride benzododecinium	A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics. Molecular weight: 304.54 Formula: C21H38N CLOGP: 3.18 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: ALOGS: -7.85 ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	2969.22	9.90	1972	66450	129917	50406785
Toxicity to various agents	1853.78	9.90	1825	66597	210674	50326028
Drug abuse	881.12	9.90	694	67728	59152	50477550
Cardio-respiratory arrest	660.72	9.90	562	67860	53330	50483372
Intentional overdose	555.03	9.90	544	67878	61960	50474742
Overdose	420.19	9.90	592	67830	99135	50437567
Cardiac arrest	357.36	9.90	500	67922	83151	50453551
Local anaesthetic systemic toxicity	318.89	9.90	87	68335	525	50536177
Alcohol interaction	314.95	9.90	116	68306	2028	50534674
Suicide attempt	271.27	9.90	342	68080	51390	50485312
Suspected suicide	244.09	9.90	127	68295	5230	50531472
Toxic anterior segment syndrome	216.40	9.90	81	68341	1484	50535218
Methaemoglobinaemia	192.12	9.90	80	68342	1962	50534740
Respiratory arrest	177.67	9.90	211	68211	29798	50506904
Alcohol poisoning	174.35	9.90	72	68350	1728	50534974
Death	150.33	9.90	849	67573	324530	50212172
Intentional product misuse	149.09	9.90	244	68178	46490	50490212
Pemphigus	140.25	9.90	5	68417	120161	50416541
Alcohol use	138.23	9.90	63	68359	1932	50534770
Systemic lupus erythematosus	114.61	9.90	25	68397	140597	50396105
Glossodynia	113.61	9.90	12	68410	115557	50421145
Alcohol abuse	109.98	9.90	53	68369	1848	50534854
Synovitis	105.13	9.90	20	68402	123845	50412857
Alopecia	104.89	9.90	106	68316	244941	50291761
Sinusitis	104.42	9.90	482	67940	170076	50366626
Drug intolerance	104.20	9.90	86	68336	219018	50317684
Joint swelling	102.84	9.90	108	68314	245178	50291524
Therapy interrupted	102.03	9.90	131	68291	20021	50516681
Abdominal discomfort	99.36	9.90	100	68322	231541	50305161
Anaesthetic complication	93.38	9.90	46	68376	1684	50535018
Drug ineffective	88.16	9.90	699	67723	818634	49718068
Contraindicated product administered	87.65	9.90	46	68376	148912	50387790
Pulseless electrical activity	80.95	9.90	70	68352	6771	50529931
Wound	78.11	9.90	23	68399	105771	50430931
Anaphylactic shock	76.45	9.90	114	68308	20041	50516661
Infusion site swelling	76.09	9.90	69	68353	7107	50529595
Exposure to toxic agent	75.30	9.90	52	68370	3606	50533096
Coma	74	9.90	206	68216	56673	50480029
Seizure	73.46	9.90	335	68087	117539	50419163
Arthralgia	72.55	9.90	326	68096	438376	50098326
Hepatic enzyme increased	71.59	9.90	49	68373	137331	50399371
Somnolence	71.03	9.90	404	68018	154581	50382121
Pericarditis	70.50	9.90	11	68411	78678	50458024
Diarrhoea	69.31	9.90	489	67933	587987	49948715
General physical health deterioration	68.80	9.90	55	68367	142379	50394323
Incorrect route of product administration	68.55	9.90	104	68318	18562	50518140
Mydriasis	68.35	9.90	78	68344	10549	50526153
Generalised tonic-clonic seizure	67.72	9.90	125	68297	26185	50510517
Rheumatoid arthritis	67.46	9.90	106	68316	202444	50334258
Maternal exposure during delivery	67.28	9.90	31	68391	975	50535727
Infusion site pain	63.66	9.90	81	68341	12265	50524437
Anaphylactic reaction	62.81	9.90	188	68234	53867	50482835
Infusion site extravasation	62.32	9.90	61	68361	6915	50529787
Ventricular tachycardia	62.18	9.90	91	68331	15730	50520972
Body tinea	62.00	9.90	32	68390	1295	50535407
Loss of consciousness	58.75	9.90	288	68134	104065	50432637
Infusion site erythema	57.73	9.90	65	68357	8662	50528040
Extradural abscess	57.63	9.90	26	68396	778	50535924
Hypotension	57.29	9.90	527	67895	234942	50301760
Unresponsive to stimuli	56.84	9.90	127	68295	30482	50506220
Infusion site pruritus	56.39	9.90	45	68377	3892	50532810
Agitation	55.84	9.90	179	68243	53205	50483497
Arthropathy	55.10	9.90	80	68342	157826	50378876
Corneal oedema	55.05	9.90	30	68392	1357	50535345
Blood alcohol increased	55.04	9.90	23	68399	569	50536133
Postmortem blood drug level abnormal	54.91	9.90	20	68402	338	50536364
Swelling	54.57	9.90	119	68303	200753	50335949
Bradycardia	53.43	9.90	200	68222	64226	50472476
Helicobacter infection	51.95	9.90	4	68418	49698	50487004
Tachycardia	51.01	9.90	268	68154	99495	50437207
Poisoning deliberate	49.08	9.90	57	68365	7855	50528847
Rash	48.74	9.90	369	68053	437102	50099600
Therapeutic product effect decreased	48.38	9.90	68	68354	135982	50400720
Alcoholism	48.11	9.90	29	68393	1591	50535111
Extradural haematoma	46.08	9.90	28	68394	1559	50535143
Lagophthalmos	43.52	9.90	16	68406	278	50536424
Pulse absent	42.89	9.90	42	68380	4764	50531938
Substance abuse	42.44	9.90	39	68383	4085	50532617
Infection susceptibility increased	42.37	9.90	32	68390	2552	50534150
Infusion site haemorrhage	42.31	9.90	34	68388	2970	50533732
Inhibitory drug interaction	41.91	9.90	30	68392	2203	50534499
Ventricular fibrillation	41.88	9.90	61	68361	10498	50526204
Procedural hypotension	41.44	9.90	23	68399	1079	50535623
Respiratory depression	40.03	9.90	64	68358	11946	50524756
Asthenia	39.45	9.90	261	68161	318781	50217921
Drug interaction	38.50	9.90	426	67996	199195	50337507
Gastrointestinal toxicity	38.28	9.90	39	68383	4638	50532064
Incorrect drug administration rate	37.78	9.90	30	68392	2576	50534126
Impaired healing	37.54	9.90	24	68398	69762	50466940
Mobility decreased	37.19	9.90	32	68390	79916	50456786
Mental status changes	36.46	9.90	120	68302	36152	50500550
Folliculitis	36.24	9.90	5	68417	39220	50497482
Electrocardiogram ST segment elevation	36.05	9.90	33	68389	3440	50533262
Fear	36.03	9.90	68	68354	14481	50522221
Hypersensitivity	34.79	9.90	161	68261	215000	50321702
Anaesthetic complication neurological	34.76	9.90	12	68410	172	50536530
Victim of sexual abuse	34.67	9.90	16	68406	505	50536197
Infusion site bruising	34.52	9.90	27	68395	2268	50534434
Off label use	34.02	9.90	445	67977	473981	50062721
Bursitis infective	33.86	9.90	21	68401	1213	50535489
Administration site pain	33.80	9.90	17	68405	651	50536051
Hypopyon	33.78	9.90	17	68405	652	50536050
Stress cardiomyopathy	33.39	9.90	47	68375	7840	50528862
COVID-19	33.14	9.90	138	68284	46524	50490178
Infusion site urticaria	32.41	9.90	19	68403	990	50535712
Anterior chamber cell	32.34	9.90	15	68407	479	50536223
Type I hypersensitivity	31.50	9.90	26	68396	2359	50534343
Neutropenia	31.49	9.90	99	68323	147866	50388836
Muscle injury	31.45	9.90	6	68416	37105	50499597
Corneal epithelium defect	31.09	9.90	13	68409	322	50536380
Pulmonary toxicity	31.09	9.90	38	68384	5524	50531178
Fear of eating	30.91	9.90	13	68409	327	50536375
Sinus tachycardia	30.42	9.90	80	68342	21274	50515428
Retinal vasculitis	30.18	9.90	17	68405	821	50535881
Platelet aggregation inhibition	30.15	9.90	10	68412	126	50536576
Blister	30.05	9.90	43	68379	85375	50451327
Drug use disorder	29.59	9.90	28	68394	3044	50533658
Pneumocephalus	29.45	9.90	10	68412	136	50536566
Vitritis	29.37	9.90	17	68405	865	50535837
Administration site swelling	29.19	9.90	18	68404	1029	50535673
Aggression	28.96	9.90	78	68344	21038	50515664
Renal injury	28.85	9.90	46	68376	8565	50528137
Discomfort	28.75	9.90	65	68357	108315	50428387
Glucose tolerance impaired	28.66	9.90	35	68387	5083	50531619
Parophthalmia	28.53	9.90	12	68410	302	50536400
Acute kidney injury	28.44	9.90	186	68236	227872	50308830
Poisoning	28.22	9.90	56	68366	12373	50524329
Product use issue	27.76	9.90	106	68316	149369	50387333
Peripheral swelling	27.73	9.90	164	68258	205772	50330930
Electrocardiogram QRS complex prolonged	27.45	9.90	35	68387	5309	50531393
Myocarditis	27.38	9.90	43	68379	7904	50528798
Treatment failure	27.28	9.90	95	68327	137542	50399160
C-reactive protein increased	26.99	9.90	30	68392	66444	50470258
Chemical submission	26.87	9.90	10	68412	180	50536522
Aqueous fibrin	26.84	9.90	8	68414	69	50536633
Pulmonary oedema	26.76	9.90	134	68288	48804	50487898
Peripheral nerve injury	25.68	9.90	12	68410	390	50536312
Septic arthritis staphylococcal	25.48	9.90	12	68410	397	50536305
Depressed level of consciousness	25.47	9.90	138	68284	51815	50484887
Anhedonia	25.45	9.90	46	68376	9478	50527224
Dyspnoea	25.40	9.90	556	67866	547052	49989650
Drug dependence	25.13	9.90	71	68351	19688	50517014
Cyanosis	24.89	9.90	60	68362	15124	50521578
Kounis syndrome	24.89	9.90	17	68405	1158	50535544
Nystagmus	24.83	9.90	34	68388	5527	50531175
Bundle branch block left	24.72	9.90	36	68386	6194	50530508
Lower respiratory tract infection	24.52	9.90	58	68364	95143	50441559
Upper airway obstruction	24.44	9.90	13	68409	560	50536142
Pancytopenia	24.29	9.90	48	68374	83982	50452720
Shock	24.14	9.90	72	68350	20578	50516124
Spinal epidural haemorrhage	24.03	9.90	8	68414	102	50536600
Abdominal pain upper	23.54	9.90	123	68299	159186	50377516
Ear infection	23.53	9.90	83	68339	25887	50510815
Disease progression	23.44	9.90	60	68362	95806	50440896
Protein C increased	23.41	9.90	8	68414	111	50536591
Infusion site nodule	23.15	9.90	16	68406	1111	50535591
Fatigue	23.01	9.90	756	67666	706845	49829857
Product adhesion issue	22.93	9.90	29	68393	4363	50532339
Cardiac failure congestive	22.87	9.90	50	68372	84332	50452370
Neurotoxicity	22.84	9.90	57	68365	14683	50522019
Drug withdrawal syndrome	22.59	9.90	80	68342	25001	50511701
Hypoxia	22.55	9.90	132	68290	50991	50485711
Meningitis chemical	22.43	9.90	8	68414	127	50536575
Drug level increased	22.35	9.90	67	68355	19201	50517501
Removal of foreign body	22.24	9.90	5	68417	11	50536691
Arthritis	22.20	9.90	53	68369	86668	50450034
Thrombocytopenia	22.15	9.90	93	68329	127580	50409122
Staphylococcal infection	21.99	9.90	101	68321	35515	50501187
Punctate keratitis	21.98	9.90	12	68410	545	50536157
Leukopenia	21.82	9.90	36	68386	67492	50469210
Nerve root injury	21.74	9.90	6	68416	38	50536664
Apnoea	21.69	9.90	36	68386	6930	50529772
Unevaluable event	21.66	9.90	121	68301	45945	50490757
Atonic urinary bladder	21.49	9.90	7	68415	83	50536619
Sensory loss	21.48	9.90	38	68384	7700	50529002
Spinal anaesthesia	21.35	9.90	6	68416	41	50536661
Poor quality sleep	21.35	9.90	60	68362	16586	50520116
Respiratory acidosis	21.30	9.90	33	68389	5995	50530707
COVID-19 immunisation	21.24	9.90	13	68409	733	50535969
Impaired quality of life	21.19	9.90	33	68389	6023	50530679
Surgery	21.19	9.90	89	68333	30116	50506586
Type 2 diabetes mellitus	21.12	9.90	10	68412	34365	50502337
Cauda equina syndrome	21.11	9.90	13	68409	741	50535961
Upper respiratory tract infection	21.07	9.90	157	68265	65741	50470961
Nerve block	20.83	9.90	11	68411	467	50536235
Hyponatraemia	20.67	9.90	64	68358	96075	50440627
Ophthalmoplegia	20.67	9.90	16	68406	1324	50535378
Infusion site rash	20.65	9.90	16	68406	1326	50535376
Psoriatic arthropathy	20.47	9.90	20	68402	47012	50489690
Trigemino-cardiac reflex	20.42	9.90	6	68416	49	50536653
Homicide	20.40	9.90	10	68412	362	50536340
Condition aggravated	20.38	9.90	281	68141	296777	50239925
Ventricular hypokinesia	20.34	9.90	26	68396	3954	50532748
Somnambulism	20.34	9.90	29	68393	4895	50531807
Abortion spontaneous	20.31	9.90	16	68406	41756	50494946
Anaemia	20.23	9.90	231	68191	252225	50284477
Spinal epidural haematoma	20.22	9.90	14	68408	975	50535727
Miosis	20.18	9.90	33	68389	6277	50530425
Neuromuscular block prolonged	20.14	9.90	11	68411	500	50536202
Infusion site mass	20.08	9.90	15	68407	1177	50535525
Circulatory collapse	19.94	9.90	66	68356	19934	50516768
Postmortem blood drug level	19.81	9.90	7	68415	108	50536594
Delirium	19.78	9.90	103	68319	38089	50498613
Drug hypersensitivity	19.22	9.90	232	68190	250778	50285924
Substance dependence	19.22	9.90	8	68414	196	50536506
Glossoptosis	19.08	9.90	6	68416	63	50536639
Orthostatic hypotension	19.02	9.90	8	68414	29473	50507229
Emotional distress	18.98	9.90	83	68339	28580	50508122
Accidental death	18.94	9.90	17	68405	1727	50534975
Status epilepticus	18.87	9.90	50	68372	13356	50523346
Ventricular extrasystoles	18.81	9.90	43	68379	10473	50526229
Loss of personal independence in daily activities	18.58	9.90	42	68380	70008	50466694
Electrocardiogram QT prolonged	18.55	9.90	127	68295	51759	50484943
Decreased appetite	18.47	9.90	178	68244	200745	50335957
Tryptase increased	18.43	9.90	8	68414	218	50536484
Induced abortion failed	18.13	9.90	8	68414	227	50536475
Pain	17.95	9.90	622	67800	578281	49958421
Infusion related reaction	17.88	9.90	145	68277	169412	50367290
Ill-defined disorder	17.79	9.90	29	68393	54625	50482077
Therapy cessation	17.75	9.90	76	68346	25935	50510767
Infusion site reaction	17.34	9.90	18	68404	2188	50534514
Accidental overdose	17.33	9.90	62	68360	19471	50517231
Amnesia	17.28	9.90	107	68315	42153	50494549
Nasopharyngitis	17.28	9.90	172	68250	192755	50343947
Areflexia	17.19	9.90	20	68402	2760	50533942
Eye infarction	17.11	9.90	5	68417	40	50536662
Alcoholic	17.11	9.90	5	68417	40	50536662
Septic shock	17.10	9.90	32	68390	57143	50479559
Injury	17.05	9.90	119	68303	48806	50487896
Hip arthroplasty	17.01	9.90	10	68412	30419	50506283
Cardiogenic shock	16.94	9.90	53	68369	15546	50521156
Serotonin syndrome	16.70	9.90	72	68350	24641	50512061
Stridor	16.67	9.90	21	68401	3148	50533554
Axillary nerve injury	16.66	9.90	4	68418	13	50536689
Anorgasmia	16.65	9.90	10	68412	545	50536157
Procedural complication	16.48	9.90	26	68396	4797	50531905
Endophthalmitis	16.42	9.90	20	68402	2896	50533806
Blood ethanol	16.39	9.90	5	68417	47	50536655
Phrenic nerve paralysis	16.39	9.90	6	68416	103	50536599
Drug reaction with eosinophilia and systemic symptoms	16.37	9.90	9	68413	28415	50508287
Malignant neoplasm progression	16.37	9.90	43	68379	68081	50468621
Femur fracture	16.22	9.90	16	68406	37448	50499254
Hypocalcaemia	16.17	9.90	8	68414	26808	50509894
Abdominal pain	15.99	9.90	224	68198	236004	50300698
Congenital umbilical hernia	15.94	9.90	8	68414	305	50536397
Blood ethanol increased	15.87	9.90	6	68416	113	50536589
Anaphylactoid shock	15.82	9.90	8	68414	310	50536392
Tracheal deviation	15.77	9.90	5	68417	54	50536648
Interstitial lung disease	15.69	9.90	30	68392	53146	50483556
Stomatitis	15.67	9.90	77	68345	101267	50435435
Nail bed tenderness	15.56	9.90	8	68414	321	50536381
Brain death	15.53	9.90	19	68403	2764	50533938
Eyelid ptosis	15.42	9.90	29	68393	6158	50530544
Incision site rash	15.29	9.90	4	68418	20	50536682
Trigeminal palsy	15.29	9.90	4	68418	20	50536682
Opiates positive	15.25	9.90	8	68414	335	50536367
Haemoglobin decreased	15.21	9.90	105	68317	127111	50409591
Neoplasm malignant	15.19	9.90	68	68354	23647	50513055
Anal sphincter atony	14.97	9.90	7	68415	228	50536474
Musculoskeletal stiffness	14.90	9.90	107	68315	128374	50408328
Blood creatinine increased	14.79	9.90	53	68369	76107	50460595
Cholestasis	14.69	9.90	8	68414	25393	50511309
Intentional self-injury	14.60	9.90	66	68356	23046	50513656
Cough	14.53	9.90	234	68188	241030	50295672
Hepatotoxicity	14.49	9.90	74	68348	27152	50509550
Administration site erythema	14.41	9.90	9	68413	526	50536176
Intentional dose omission	14.28	9.90	25	68397	5025	50531677
Dissociative amnesia	14.28	9.90	4	68418	27	50536675
Administration site extravasation	14.26	9.90	10	68412	711	50535991
Pruritus	14.24	9.90	284	68138	283284	50253418
Body dysmorphic disorder	14.17	9.90	7	68415	258	50536444
Pupillary reflex impaired	14.16	9.90	15	68407	1866	50534836
Systemic toxicity	14.15	9.90	4	68418	28	50536674
Amphetamines positive	14.08	9.90	6	68416	156	50536546
Illness	13.98	9.90	68	68354	24472	50512230
Anaphylactoid reaction	13.98	9.90	20	68402	3386	50533316
Gastroenteritis	13.96	9.90	7	68415	23274	50513428
Paralysis	13.95	9.90	34	68388	8630	50528072
Blood cholesterol increased	13.93	9.90	34	68388	55181	50481521
Propionibacterium infection	13.80	9.90	4	68418	31	50536671
Vitamin D increased	13.75	9.90	9	68413	571	50536131
Arthritis bacterial	13.56	9.90	26	68396	5603	50531099
Brain injury	13.54	9.90	27	68395	5987	50530715
Road traffic accident	13.53	9.90	67	68355	24285	50512417
Airway peak pressure increased	13.46	9.90	7	68415	288	50536414
Red blood cell sedimentation rate increased	13.40	9.90	12	68410	29404	50507298
Vascular resistance systemic decreased	13.24	9.90	5	68417	94	50536608
Disinhibition	13.21	9.90	10	68412	800	50535902
Malaise	13.21	9.90	349	68073	335183	50201519
Harlequin syndrome	13.17	9.90	4	68418	37	50536665
Genital ulceration	13.17	9.90	8	68414	445	50536257
Implant site swelling	12.99	9.90	8	68414	456	50536246
Asphyxia	12.99	9.90	25	68397	5402	50531300
Conjunctival oedema	12.91	9.90	9	68413	634	50536068
Multiple sclerosis relapse	12.88	9.90	24	68398	42940	50493762
Orbital infection	12.80	9.90	4	68418	41	50536661
Anal skin tags	12.80	9.90	7	68415	319	50536383
Application site alopecia	12.68	9.90	3	68419	9	50536693
Prescribed underdose	12.65	9.90	3	68419	15946	50520756
Adverse event	12.64	9.90	25	68397	43738	50492964
Product contamination microbial	12.59	9.90	6	68416	204	50536498
Osteoarthritis	12.50	9.90	49	68373	68557	50468145
Suicidal ideation	12.45	9.90	122	68300	55263	50481439
Bone density decreased	12.37	9.90	38	68384	11037	50525665
Visual acuity reduced	12.35	9.90	57	68365	20082	50516620
Pain in extremity	12.32	9.90	278	68144	272587	50264115
Cardiac death	12.31	9.90	8	68414	501	50536201
Cholestasis of pregnancy	12.24	9.90	11	68411	1120	50535582
Metabolic acidosis	12.13	9.90	92	68330	38733	50497969
Psoriasis	12.12	9.90	50	68372	68950	50467752
Peritonitis	12.11	9.90	3	68419	15483	50521219
Intentional product use issue	12.10	9.90	158	68264	76760	50459942
Foetal heart rate abnormal	12.07	9.90	8	68414	518	50536184
Fear-related avoidance of activities	12.03	9.90	5	68417	122	50536580
Purpura	12.01	9.90	35	68387	9876	50526826
Spinal cord oedema	11.99	9.90	5	68417	123	50536579
Inadequate analgesia	11.97	9.90	16	68406	2542	50534160
Dermatitis contact	11.92	9.90	32	68390	8614	50528088
Osteonecrosis of jaw	11.81	9.90	16	68406	32510	50504192
Left ventricle outflow tract obstruction	11.73	9.90	6	68416	238	50536464
Bronchitis	11.72	9.90	202	68220	103957	50432745
Device expulsion	11.70	9.90	13	68409	28809	50507893
Knee arthroplasty	11.68	9.90	19	68403	35827	50500875
Birth mark	11.63	9.90	5	68417	133	50536569
Blood pressure decreased	11.53	9.90	121	68301	55788	50480914
Arthritis fungal	11.47	9.90	3	68419	15	50536687
Coccygectomy	11.47	9.90	3	68419	15	50536687
Kidney infection	11.45	9.90	53	68369	18693	50518009
Weight decreased	11.28	9.90	221	68201	221024	50315678
Autonomic neuropathy	11.25	9.90	10	68412	1003	50535699
Pneumocystis jirovecii pneumonia	11.16	9.90	3	68419	14660	50522042
Vascular stenosis	11.10	9.90	6	68416	267	50536435
Pupil fixed	11.02	9.90	12	68410	1540	50535162
Post procedural complication	10.98	9.90	45	68377	15059	50521643
Lung disorder	10.97	9.90	28	68394	44771	50491931
Drug resistance	10.96	9.90	6	68416	18983	50517719
Neoplasm progression	10.93	9.90	14	68408	29143	50507559
Repetitive strain injury	10.92	9.90	5	68417	155	50536547
Haemorrhagic vasculitis	10.91	9.90	4	68418	69	50536633
Liver injury	10.90	9.90	64	68358	24742	50511960
Cerebral congestion	10.87	9.90	3	68419	19	50536683
Intercepted medication error	10.87	9.90	7	68415	432	50536270
Retinal cyst	10.85	9.90	4	68418	70	50536632
Toxicologic test abnormal	10.85	9.90	8	68414	615	50536087
Ataxia	10.76	9.90	42	68380	13744	50522958
Pneumonia mycoplasmal	10.68	9.90	9	68413	840	50535862
Agranulocytosis	10.67	9.90	8	68414	21413	50515289
Paranasal cyst	10.61	9.90	6	68416	292	50536410
Gastrointestinal haemorrhage	10.60	9.90	57	68365	73264	50463438
Hemiplegic migraine	10.60	9.90	4	68418	75	50536627
Haematochezia	10.50	9.90	24	68398	39858	50496844
Neurogenic shock	10.50	9.90	6	68416	298	50536404
White blood cell count decreased	10.47	9.90	104	68318	116618	50420084
Blood pressure systolic increased	10.46	9.90	20	68402	35429	50501273
Infusion site discomfort	10.42	9.90	9	68413	869	50535833
Anxiety	10.39	9.90	314	68108	177292	50359410
Drug eruption	10.32	9.90	10	68412	23596	50513106
Transferrin decreased	10.30	9.90	5	68417	177	50536525
Fanconi syndrome	10.27	9.90	10	68412	1126	50535576
Cranial nerve palsies multiple	10.26	9.90	3	68419	24	50536678
Femoral nerve injury	10.26	9.90	3	68419	24	50536678
Withdrawal syndrome	10.21	9.90	49	68373	17541	50519161
Electrocardiogram ST segment depression	10.19	9.90	15	68407	2605	50534097
Blood lactic acid increased	10.17	9.90	23	68399	5562	50531140
Obesity	10.12	9.90	5	68417	16770	50519932
Product administration error	10.11	9.90	53	68369	19646	50517056
Spinal cord compression	10.02	9.90	18	68404	3691	50533011
Diplopia	10.01	9.90	52	68370	19208	50517494
Exposure during pregnancy	10.00	9.90	224	68198	120791	50415911

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	2886.05	11.06	1727	46725	78156	29447919
Toxicity to various agents	2353.99	11.06	2069	46383	171592	29354483
Completed suicide	2332.28	11.06	1580	46872	88666	29437409
Cardio-respiratory arrest	523.40	11.06	522	47930	50079	29475996
Intentional overdose	522.39	11.06	462	47990	38066	29488009
Overdose	445.63	11.06	599	47853	79220	29446855
Alcohol abuse	396.45	11.06	176	48276	4157	29521918
Alcohol interaction	376.00	11.06	148	48304	2555	29523520
Intentional product misuse	306.53	11.06	329	48123	34332	29491743
Suicide attempt	277.68	11.06	310	48142	33800	29492275
Suspected suicide	258.53	11.06	128	48324	3892	29522183
Substance abuse	218.33	11.06	137	48315	6650	29519425
Methaemoglobinaemia	204.93	11.06	96	48356	2575	29523500
Cardiac arrest	198.59	11.06	435	48017	85156	29440919
Alcohol poisoning	194.61	11.06	97	48355	2992	29523083
Respiratory arrest	175.45	11.06	214	48238	25619	29500456
Drug dependence	167.77	11.06	189	48263	20792	29505283
Respiratory depression	151.60	11.06	146	48306	13377	29512698
Coma	142.46	11.06	242	48210	39208	29486867
Alcohol use	118.10	11.06	70	48382	3062	29523013
Anaesthetic complication	113.05	11.06	47	48405	939	29525136
Diarrhoea	112.51	11.06	236	48216	332462	29193613
Anaphylactic reaction	111.44	11.06	178	48274	27395	29498680
Aggression	97.90	11.06	194	48258	35347	29490728
Exposure to toxic agent	93.05	11.06	56	48396	2519	29523556
Toxic anterior segment syndrome	91.28	11.06	41	48411	995	29525080
Incorrect route of product administration	90.95	11.06	100	48352	10701	29515374
Asphyxia	84.65	11.06	70	48382	5245	29520830
Tachycardia	80.22	11.06	281	48171	72129	29453946
Poisoning deliberate	80.05	11.06	70	48382	5661	29520414
Injury	79.77	11.06	125	48327	18921	29507154
Hypotension	78.64	11.06	566	47886	193788	29332287
Death	78.57	11.06	880	47572	341204	29184871
Blood alcohol increased	77.69	11.06	33	48419	697	29525378
Fear	73.20	11.06	84	48368	9420	29516655
Intentional product use issue	71.53	11.06	191	48261	42307	29483768
Poisoning	71.42	11.06	85	48367	9908	29516167
Unresponsive to stimuli	71.41	11.06	139	48313	24987	29501088
Anaemia	69.88	11.06	140	48312	200811	29325264
Anaphylactic shock	68.01	11.06	96	48356	13240	29512835
Mydriasis	66.87	11.06	65	48387	6020	29520055
Miosis	62.04	11.06	71	48381	7938	29518137
Renal injury	60.46	11.06	79	48373	10123	29515952
Ventricular tachycardia	59.48	11.06	121	48331	22453	29503622
Local anaesthetic systemic toxicity	58.95	11.06	19	48433	176	29525899
General physical health deterioration	56.70	11.06	51	48401	102806	29423269
Dyspnoea	53.24	11.06	316	48136	326416	29199659
Anhedonia	52.70	11.06	62	48390	7138	29518937
Emotional distress	52.45	11.06	87	48365	13808	29512267
Decreased appetite	52.43	11.06	99	48353	145243	29380832
Weight decreased	49.99	11.06	108	48344	150797	29375278
Fatigue	49.72	11.06	310	48142	316511	29209564
Accidental overdose	49.59	11.06	97	48355	17496	29508579
Disease progression	47.10	11.06	39	48413	81877	29444198
Alcohol withdrawal syndrome	44.86	11.06	28	48424	1345	29524730
Drug withdrawal syndrome	44.56	11.06	94	48358	17890	29508185
Medication error	43.71	11.06	103	48349	21108	29504967
Interstitial lung disease	43.55	11.06	20	48432	57698	29468377
Pulmonary oedema	42.34	11.06	160	48292	42575	29483500
Electrocardiogram QRS complex prolonged	41.63	11.06	42	48410	4068	29522007
Rash	41.63	11.06	165	48287	189654	29336421
Pyrexia	40.78	11.06	290	48162	287332	29238743
Drug screen positive	40.64	11.06	40	48412	3761	29522314
Generalised tonic-clonic seizure	40.60	11.06	94	48358	19045	29507030
Drug use disorder	40.34	11.06	38	48414	3384	29522691
Suicidal ideation	39.50	11.06	136	48316	34580	29491495
Brain oedema	38.93	11.06	71	48381	12149	29513926
Electrocardiogram ST segment elevation	38.52	11.06	42	48410	4450	29521625
Neutropenia	38.25	11.06	101	48351	131610	29394465
Accidental death	38.19	11.06	30	48422	2088	29523987
Loss of consciousness	37.28	11.06	228	48224	73828	29452247
Asthenia	37.22	11.06	204	48248	215046	29311029
Cardiac failure congestive	36.49	11.06	43	48409	76538	29449537
Therapy interrupted	36.44	11.06	56	48396	8330	29517745
Depressed level of consciousness	36.33	11.06	138	48314	36804	29489271
Agitation	36.02	11.06	173	48279	51131	29474944
Alcohol intolerance	35.97	11.06	16	48436	379	29525696
Road traffic accident	35.87	11.06	79	48373	15482	29510593
Anaesthetic complication neurological	35.61	11.06	15	48437	310	29525765
Haemoglobin decreased	35.50	11.06	78	48374	108297	29417778
Ventricular fibrillation	34.95	11.06	79	48373	15754	29510321
Malaise	34.80	11.06	139	48313	159463	29366612
Ex-drug abuser	34.60	11.06	12	48440	142	29525933
White blood cell count decreased	34.43	11.06	52	48400	83310	29442765
Sinus tachycardia	34.17	11.06	76	48376	14993	29511082
Arthralgia	34.11	11.06	116	48336	139501	29386574
Pneumonia	34.07	11.06	348	48104	319824	29206251
Off label use	33.23	11.06	324	48128	300476	29225599
Myocardial infarction	33.22	11.06	83	48369	110213	29415862
Metabolic acidosis	32.46	11.06	135	48317	37527	29488548
Platelet count decreased	32.13	11.06	78	48374	104594	29421481
Oedema peripheral	31.92	11.06	77	48375	103480	29422595
Drug intolerance	31.76	11.06	20	48432	48359	29477716
Abdominal pain	30.71	11.06	116	48336	135241	29390834
Bradycardia	30.50	11.06	198	48254	65431	29460644
Acute kidney injury	30.43	11.06	283	48169	264984	29261091
Alcoholism	30.32	11.06	29	48423	2632	29523443
Oculocardiac reflex	30.26	11.06	9	48443	62	29526013
Drug abuser	29.76	11.06	34	48418	3793	29522282
Shock	28.99	11.06	89	48363	21315	29504760
Dehydration	28.24	11.06	95	48357	114653	29411422
Pain in extremity	28.17	11.06	90	48362	110343	29415732
Homicide	28.01	11.06	18	48434	910	29525165
Sinusitis	27.95	11.06	121	48331	34229	29491846
Cardiac failure	27.69	11.06	55	48397	79232	29446843
Intentional self-injury	27.31	11.06	62	48390	12399	29513676
Condition aggravated	27.30	11.06	135	48317	146160	29379915
Cough	27.21	11.06	111	48341	126616	29399459
Malignant neoplasm progression	26.87	11.06	50	48402	73809	29452266
Dysarthria	26.79	11.06	111	48341	30800	29495275
Infusion site pain	26.23	11.06	28	48424	2897	29523178
Thrombocytopenia	25.97	11.06	123	48329	134700	29391375
Impaired driving ability	25.80	11.06	25	48427	2306	29523769
Myocardial fibrosis	25.71	11.06	18	48434	1050	29525025
Hepatic fibrosis	25.47	11.06	29	48423	3223	29522852
Removal of foreign body	25.29	11.06	6	48446	14	29526061
Myalgia	24.45	11.06	53	48399	73966	29452109
Embolia cutis medicamentosa	24.37	11.06	10	48442	193	29525882
Unevaluable event	24.17	11.06	105	48347	29746	29496329
Foetal alcohol syndrome	23.95	11.06	9	48443	136	29525939
Drug reaction with eosinophilia and systemic symptoms	23.91	11.06	8	48444	27984	29498091
Neuropathy peripheral	23.34	11.06	51	48401	70976	29455099
Rheumatoid arthritis	22.94	11.06	12	48440	32140	29493935
Cytomegalovirus infection	22.90	11.06	5	48447	23210	29502865
Bezoar	22.56	11.06	15	48437	804	29525271
Corneal oedema	22.39	11.06	17	48435	1125	29524950
Angina pectoris	22.03	11.06	9	48443	27841	29498234
Haematochezia	22.00	11.06	17	48435	36966	29489109
Circulatory collapse	21.98	11.06	74	48378	18599	29507476
Diabetes mellitus	21.63	11.06	20	48432	39811	29486264
Behaviour disorder	21.42	11.06	28	48424	3588	29522487
Spinal cord infarction	21.35	11.06	10	48442	268	29525807
Leukopenia	21.31	11.06	36	48416	55167	29470908
Blood creatinine increased	21.24	11.06	70	48382	85032	29441043
Agranulocytosis	20.85	11.06	4	48448	20336	29505739
Opiates positive	20.55	11.06	12	48440	510	29525565
Loss of personal independence in daily activities	20.49	11.06	8	48444	25432	29500643
Pulmonary embolism	20.48	11.06	61	48391	76473	29449602
Intracranial hypotension	20.36	11.06	9	48443	210	29525865
Pupil fixed	20.31	11.06	19	48433	1677	29524398
Psoriasis	20.23	11.06	14	48438	32213	29493862
Coronary artery disease	19.79	11.06	26	48426	44164	29481911
Somnolence	19.72	11.06	238	48214	93717	29432358
Anxiety	19.59	11.06	220	48232	85145	29440930
Restlessness	19.56	11.06	80	48372	22065	29504010
Eosinophilia	19.51	11.06	6	48446	22155	29503920
Accident	19.47	11.06	27	48425	3661	29522414
Lagophthalmos	19.45	11.06	7	48445	93	29525982
Pancytopenia	19.02	11.06	71	48381	83097	29442978
Respiratory acidosis	18.94	11.06	29	48423	4299	29521776
Apnoea	18.86	11.06	35	48417	6067	29520008
Therapeutic product effect incomplete	18.79	11.06	22	48430	39283	29486792
Acute pulmonary oedema	18.64	11.06	37	48415	6742	29519333
Asthma	18.37	11.06	17	48435	33832	29492243
Sopor	18.23	11.06	49	48403	10885	29515190
Dextrocardia	18.15	11.06	7	48445	114	29525961
Reperfusion arrhythmia	17.94	11.06	6	48446	63	29526012
Dyspnoea exertional	17.90	11.06	20	48432	36470	29489605
Tryptase increased	17.89	11.06	8	48444	192	29525883
Pruritus	17.89	11.06	115	48337	116734	29409341
Amnesia	17.83	11.06	79	48373	22564	29503511
Weight increased	17.82	11.06	65	48387	76602	29449473
Melaena	17.71	11.06	15	48437	31161	29494914
Sensorimotor disorder	17.70	11.06	10	48442	399	29525676
Deep vein thrombosis	17.42	11.06	43	48409	57356	29468719
Gastrointestinal disorder	17.33	11.06	13	48439	28693	29497382
Tubulointerstitial nephritis	17	11.06	4	48448	17639	29508436
Catecholamine crisis	16.86	11.06	5	48447	34	29526041
Sepsis	16.84	11.06	151	48301	142531	29383544
Haematuria	16.84	11.06	29	48423	44110	29481965
Endophthalmitis	16.79	11.06	22	48430	2826	29523249
Product adhesion issue	16.70	11.06	16	48436	1455	29524620
Physical assault	16.68	11.06	14	48438	1070	29525005
Wrong product administered	16.60	11.06	28	48424	4503	29521572
Nausea	16.49	11.06	355	48097	288900	29237175
Substance-induced mood disorder	16.26	11.06	6	48446	86	29525989
Injection site ulcer	16.19	11.06	8	48444	242	29525833
Aqueous fibrin	16.16	11.06	5	48447	40	29526035
Anal sphincter atony	16.13	11.06	6	48446	88	29525987
Pulmonary fibrosis	16.11	11.06	3	48449	15579	29510496
Vitreous disorder	16.07	11.06	6	48446	89	29525986
Abdominal discomfort	16.06	11.06	34	48418	47869	29478206
Pneumocystis jirovecii pneumonia	15.79	11.06	4	48448	16775	29509300
Trigemino-cardiac reflex	15.50	11.06	7	48445	172	29525903
Drug resistance	15.42	11.06	8	48444	21532	29504543
Pulse absent	15.40	11.06	29	48423	5084	29520991
Electrocardiogram T wave amplitude increased	15.35	11.06	5	48447	48	29526027
Toxicologic test abnormal	15.26	11.06	10	48442	523	29525552
Withdrawal syndrome	15.16	11.06	46	48406	10946	29515129
Administration site pain	15.14	11.06	7	48445	182	29525893
Drug level increased	15.14	11.06	66	48386	18721	29507354
Product preparation error	15.06	11.06	16	48436	1646	29524429
Myoclonus	15.01	11.06	52	48400	13257	29512818
Blood pressure fluctuation	14.83	11.06	7	48445	19887	29506188
Diabetic ketoacidosis	14.80	11.06	4	48448	16069	29510006
Transient ischaemic attack	14.75	11.06	10	48442	23260	29502815
Delayed recovery from anaesthesia	14.70	11.06	11	48441	712	29525363
Product dose omission issue	14.68	11.06	95	48357	96288	29429787
Gun shot wound	14.65	11.06	13	48439	1072	29525003
Bone marrow failure	14.64	11.06	14	48438	27435	29498640
Phaeochromocytoma crisis	14.58	11.06	5	48447	57	29526018
Disease recurrence	14.58	11.06	4	48448	15910	29510165
Retinal vasculitis	14.23	11.06	8	48444	316	29525759
Ear infection	14.22	11.06	37	48415	8063	29518012
Hypoxia	14.18	11.06	129	48323	47250	29478825
Somnambulism	14.05	11.06	20	48432	2778	29523297
Stress	14.02	11.06	71	48381	21419	29504656
Musculoskeletal stiffness	13.93	11.06	25	48427	37433	29488642
Suicidal behaviour	13.92	11.06	14	48438	1351	29524724
Hepatic function abnormal	13.90	11.06	27	48425	39232	29486843
Drug interaction	13.81	11.06	422	48030	196963	29329112
Vitreous floaters	13.78	11.06	21	48431	3100	29522975
Red blood cell count decreased	13.72	11.06	13	48439	25589	29500486
Haemoptysis	13.65	11.06	18	48434	30532	29495543
Postmortem blood drug level	13.53	11.06	6	48446	141	29525934
Blood ethanol	13.40	11.06	5	48447	74	29526001
Acute myocardial infarction	13.39	11.06	38	48414	48400	29477675
Feeling drunk	13.31	11.06	15	48437	1649	29524426
Tracheitis	13.29	11.06	10	48442	653	29525422
Brachial plexus injury	13.28	11.06	5	48447	76	29525999
Dyspepsia	13.21	11.06	18	48434	30107	29495968
Corneal opacity	13.18	11.06	9	48443	504	29525571
Cardiotoxicity	13.17	11.06	26	48426	4718	29521357
Administration related reaction	12.93	11.06	5	48447	82	29525993
Muscular weakness	12.90	11.06	55	48397	61997	29464078
Infusion site bruising	12.88	11.06	8	48444	381	29525694
Product administration error	12.88	11.06	52	48400	14258	29511817
Mobility decreased	12.79	11.06	14	48438	25766	29500309
Proteinuria	12.67	11.06	5	48447	15799	29510276
Myokymia	12.66	11.06	5	48447	87	29525988
Prostate cancer	12.51	11.06	14	48438	25513	29500562
Accidental poisoning	12.50	11.06	9	48443	549	29525526
Alcoholic liver disease	12.47	11.06	9	48443	551	29525524
Blood pressure systolic increased	12.45	11.06	6	48446	16839	29509236
Infusion site extravasation	12.37	11.06	20	48432	3107	29522968
Jaundice	12.35	11.06	18	48434	29278	29496797
Oesophageal obstruction	12.30	11.06	8	48444	413	29525662
Chemical poisoning	12.26	11.06	5	48447	95	29525980
Postmortem blood drug level abnormal	12.20	11.06	7	48445	288	29525787
Psychiatric disorder prophylaxis	12.14	11.06	4	48448	40	29526035
Bronchospasm	12.13	11.06	39	48413	9570	29516505
International normalised ratio increased	12.13	11.06	35	48417	44337	29481738
Septic shock	12.07	11.06	57	48395	62503	29463572
Infusion site swelling	11.89	11.06	15	48437	1855	29524220
Blindness	11.88	11.06	45	48407	11978	29514097
Hypertonia	11.88	11.06	22	48430	3807	29522268
Gastrointestinal haemorrhage	11.80	11.06	79	48373	79454	29446621
Phlebitis superficial	11.77	11.06	7	48445	308	29525767
Neuromuscular blockade	11.75	11.06	6	48446	195	29525880
Seizure	11.71	11.06	216	48236	92907	29433168
Drug hypersensitivity	11.69	11.06	65	48387	68341	29457734
Surgery	11.57	11.06	44	48408	11735	29514340
Ophthalmoplegia	11.51	11.06	14	48438	1668	29524407
Diaphragmatic paralysis	11.51	11.06	8	48444	461	29525614
Benzodiazepine drug level therapeutic	11.48	11.06	4	48448	48	29526027
Drug diversion	11.47	11.06	10	48442	805	29525270
Ascites	11.45	11.06	27	48425	36592	29489483
Chronic obstructive pulmonary disease	11.42	11.06	32	48420	40923	29485152
Haemodynamic instability	11.33	11.06	34	48418	8039	29518036
Hypoxic-ischaemic encephalopathy	11.32	11.06	23	48429	4261	29521814
Cluster headache	11.26	11.06	8	48444	478	29525597
Hyperkalaemia	11.23	11.06	57	48395	61335	29464740
Blood ethanol increased	11.18	11.06	8	48444	483	29525592
Myocardial stunning	11.07	11.06	3	48449	14	29526061
Alopecia	11.06	11.06	9	48443	19075	29507000

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	5134.37	10.04	3508	92324	220906	64181994
Toxicity to various agents	4119.22	10.04	3754	92078	359759	64043141
Drug abuse	3583.32	10.04	2303	93529	130071	64272829
Cardio-respiratory arrest	1204.50	10.04	1067	94765	97326	64305574
Intentional overdose	885.03	10.04	864	94968	89080	64313820
Overdose	733.72	10.04	1037	94795	158529	64244371
Alcohol interaction	574.37	10.04	224	95608	4177	64398723
Cardiac arrest	562.06	10.04	899	94933	153165	64249735
Suspected suicide	463.85	10.04	236	95596	8418	64394482
Intentional product misuse	433.96	10.04	536	95296	71759	64331141
Alcohol abuse	371.47	10.04	169	95663	4683	64398217
Respiratory arrest	350.85	10.04	413	95419	52572	64350328
Local anaesthetic systemic toxicity	337.01	10.04	95	95737	590	64402310
Suicide attempt	330.92	10.04	465	95367	70542	64332358
Methaemoglobinaemia	328.31	10.04	150	95682	4198	64398702
Death	319.06	10.04	1489	94343	481216	63921684
Alcohol poisoning	303.18	10.04	141	95691	4114	64398786
Toxic anterior segment syndrome	300.19	10.04	119	95713	2320	64400580
Alcohol use	216.49	10.04	115	95717	4487	64398413
Substance abuse	209.88	10.04	145	95687	9147	64393753
Anaesthetic complication	197.95	10.04	90	95742	2489	64400411
Coma	187.52	10.04	407	95425	87208	64315692
Anaphylactic reaction	182.57	10.04	349	95483	68315	64334585
Diarrhoea	171.84	10.04	529	95303	722175	63680725
Incorrect route of product administration	168.26	10.04	190	95642	23108	64379792
Drug dependence	166.88	10.04	226	95606	33086	64369814
Exposure to toxic agent	162.86	10.04	106	95726	6053	64396847
Respiratory depression	148.94	10.04	179	95653	23264	64379636
Anaphylactic shock	146.24	10.04	202	95630	30126	64372774
Arthralgia	138.14	10.04	281	95551	441979	63960921
Hypotension	135.54	10.04	999	94833	379975	64022925
Therapy interrupted	133.91	10.04	157	95675	19879	64383021
Unresponsive to stimuli	122.84	10.04	247	95585	50146	64352754
Joint swelling	116.12	10.04	90	95742	215292	64187608
Blood alcohol increased	115.87	10.04	49	95783	1133	64401767
Drug intolerance	114.07	10.04	69	95763	187923	64214977
Mydriasis	112.48	10.04	126	95706	15186	64387714
General physical health deterioration	112.02	10.04	84	95748	204341	64198559
Tachycardia	110.66	10.04	478	95354	149101	64253799
Poisoning deliberate	109.74	10.04	117	95715	13341	64389559
Synovitis	107.79	10.04	11	95821	99079	64303821
Fear	101.24	10.04	137	95695	20034	64382866
Generalised tonic-clonic seizure	100.31	10.04	198	95634	39659	64363241
Ventricular tachycardia	98.32	10.04	180	95652	34085	64368815
Aggression	96.85	10.04	213	95619	46019	64356881
Renal injury	93.43	10.04	115	95717	15314	64387586
Fatigue	88.15	10.04	702	95130	748028	63654872
Rheumatoid arthritis	83.14	10.04	73	95759	164221	64238679
Loss of consciousness	82.04	10.04	436	95396	147929	64254971
Agitation	81.01	10.04	302	95530	88065	64314835
Pulmonary oedema	80.75	10.04	279	95553	78395	64324505
Miosis	80.53	10.04	99	95733	13167	64389733
Abdominal discomfort	77.57	10.04	94	95738	182228	64220672
Poisoning	77.26	10.04	126	95706	21753	64381147
Pulseless electrical activity	77.22	10.04	95	95737	12644	64390256
Rash	77.02	10.04	385	95447	458164	63944736
Anhedonia	74.81	10.04	97	95735	13609	64389291
Asphyxia	74.20	10.04	81	95751	9485	64393415
Asthenia	73.25	10.04	357	95475	427687	63975213
Electrocardiogram QRS complex prolonged	72.97	10.04	79	95753	9165	64393735
Off label use	72.23	10.04	598	95234	632208	63770692
Pemphigus	70.77	10.04	5	95827	60696	64342204
Sinus tachycardia	70.49	10.04	151	95681	32037	64370863
Bradycardia	69.20	10.04	353	95479	117866	64285034
Anaemia	68.80	10.04	309	95523	378371	64024529
Corneal oedema	68.58	10.04	43	95789	2300	64400600
Systemic lupus erythematosus	67.77	10.04	16	95816	77596	64325304
Dyspnoea	67.10	10.04	714	95118	717960	63684940
Ventricular fibrillation	66.76	10.04	124	95708	23736	64379164
Seizure	66.36	10.04	450	95382	166442	64236458
Nasopharyngitis	65.05	10.04	120	95712	195953	64206947
Anaesthetic complication neurological	65.01	10.04	26	95806	519	64402381
Maternal exposure during delivery	64.98	10.04	30	95802	860	64402040
Drug use disorder	64.78	10.04	61	95771	5993	64396907
Postmortem blood drug level abnormal	64.02	10.04	27	95805	620	64402280
Contraindicated product administered	63.41	10.04	41	95791	107788	64295112
Pericarditis	62.92	10.04	9	95823	62507	64340393
Injury	62.25	10.04	204	95628	55788	64347112
Alopecia	61.80	10.04	94	95738	165596	64237304
Arthropathy	60.88	10.04	54	95778	120913	64281987
Lagophthalmos	60.67	10.04	22	95810	332	64402568
Therapeutic product effect decreased	59.87	10.04	50	95782	115301	64287599
Neutropenia	59.81	10.04	171	95661	239453	64163447
Accidental overdose	59.70	10.04	145	95687	33412	64369488
Extradural abscess	59.54	10.04	31	95801	1160	64401740
Intentional product use issue	57.38	10.04	287	95545	95077	64307823
Glossodynia	57.15	10.04	13	95819	64683	64338217
Body tinea	57.14	10.04	31	95801	1262	64401638
Emotional distress	57.08	10.04	149	95683	35889	64367011
Shock	56.42	10.04	154	95678	38086	64364814
Disease progression	56.16	10.04	77	95755	141603	64261297
Hepatic enzyme increased	55.24	10.04	67	95765	129876	64273024
Accidental death	54.85	10.04	45	95787	3680	64399220
Cough	54.57	10.04	247	95585	301901	64100999
Malaise	54.45	10.04	355	95477	395892	64007008
Decreased appetite	54.43	10.04	224	95608	281065	64121835
Unevaluable event	54.38	10.04	182	95650	50307	64352593
Pulse absent	53.07	10.04	66	95766	8880	64394020
Depressed level of consciousness	52.51	10.04	250	95582	81186	64321714
Electrocardiogram ST segment elevation	52.06	10.04	59	95773	7200	64395700
Acute kidney injury	51.39	10.04	424	95408	448816	63954084
Infusion related reaction	50.77	10.04	105	95727	164362	64238538
Weight decreased	50.16	10.04	236	95596	285503	64117397
Alcoholism	49.73	10.04	41	95791	3376	64399524
Pain in extremity	49.37	10.04	257	95575	302828	64100072
Procedural hypotension	48.74	10.04	32	95800	1854	64401046
Interstitial lung disease	48.73	10.04	44	95788	97688	64305212
Metabolic acidosis	47.33	10.04	220	95612	70738	64332162
Mobility decreased	47.33	10.04	35	95797	85805	64317095
Extradural haematoma	47.30	10.04	36	95796	2640	64400260
Somnolence	47.06	10.04	486	95346	203159	64199741
Pyrexia	46.17	10.04	570	95262	558074	63844826
Cardiac failure congestive	45.93	10.04	77	95755	130503	64272397
Drug hypersensitivity	45.61	10.04	190	95642	237625	64165275
Product adhesion issue	45.50	10.04	34	95798	2425	64400475
Helicobacter infection	45.18	10.04	3	95829	38359	64364541
Drug reaction with eosinophilia and systemic symptoms	43.87	10.04	13	95819	54204	64348696
Retinal vasculitis	43.85	10.04	25	95807	1122	64401778
Abdominal pain	43.31	10.04	279	95553	312096	64090804
Removal of foreign body	42.36	10.04	10	95822	26	64402874
Condition aggravated	42.33	10.04	352	95480	372074	64030826
Musculoskeletal stiffness	41.20	10.04	75	95757	123131	64279769
Homicide	41.11	10.04	24	95808	1127	64401773
Apnoea	40.90	10.04	63	95769	10359	64392541
Hypopyon	40.88	10.04	23	95809	1006	64401894
Respiratory acidosis	40.70	10.04	61	95771	9794	64393106
Alcohol withdrawal syndrome	40.39	10.04	28	95804	1775	64401125
Peripheral swelling	40.16	10.04	167	95665	208986	64193914
Drug interaction	40.12	10.04	758	95074	361325	64041575
Anterior chamber cell	39.91	10.04	21	95811	803	64402097
Abdominal pain upper	38.64	10.04	132	95700	174898	64228002
Drug screen positive	38.45	10.04	45	95787	5684	64397216
Arthritis	38.02	10.04	41	95791	83773	64319127
Hypoxia	37.61	10.04	242	95590	87907	64314993
Circulatory collapse	37.57	10.04	123	95709	33609	64369291
Aqueous fibrin	37.48	10.04	12	95820	121	64402779
Drug level increased	37.47	10.04	124	95708	34072	64368828
Thrombocytopenia	37.42	10.04	188	95644	223613	64179287
Pancytopenia	37.42	10.04	100	95732	143209	64259691
Swelling	37.31	10.04	118	95714	160100	64242800
Vitritis	37.17	10.04	25	95807	1508	64401392
Mental status changes	36.72	10.04	184	95648	60978	64341922
Fear of eating	36.72	10.04	16	95816	399	64402501
Nausea	36.65	10.04	889	94943	784911	63617989
Drug abuser	36.31	10.04	44	95788	5764	64397136
Wound	36.28	10.04	36	95796	76441	64326459
Infection susceptibility increased	36.15	10.04	31	95801	2695	64400205
Pruritus	36.06	10.04	294	95538	312106	64090794
Lower respiratory tract infection	35.92	10.04	53	95779	94561	64308339
Opiates positive	35.48	10.04	20	95812	878	64402022
Leukopenia	35.32	10.04	60	95772	101182	64301718
Malignant neoplasm progression	34.87	10.04	72	95760	112799	64290101
Medication error	34.86	10.04	157	95675	49809	64353091
Brain oedema	34.68	10.04	91	95741	21984	64380916
Endophthalmitis	34.12	10.04	41	95791	5324	64397576
Therapy cessation	34.00	10.04	116	95716	32373	64370527
Trigemino-cardiac reflex	33.90	10.04	13	95819	231	64402669
Haemoglobin decreased	33.68	10.04	162	95670	194901	64207999
Intentional self-injury	33.34	10.04	107	95725	28937	64373963
Postmortem blood drug level	32.81	10.04	13	95819	253	64402647
Road traffic accident	32.37	10.04	110	95722	30635	64372265
Ophthalmoplegia	32.36	10.04	29	95803	2673	64400227
Tryptase increased	31.95	10.04	15	95817	447	64402453
Cauda equina syndrome	31.68	10.04	20	95812	1083	64401817
Agranulocytosis	31.23	10.04	9	95823	38220	64364680
Oculocardiac reflex	31.12	10.04	9	95823	62	64402838
Folliculitis	31.04	10.04	4	95828	30073	64372827
Stress cardiomyopathy	30.92	10.04	52	95780	9205	64393695
Haematochezia	30.62	10.04	32	95800	66341	64336559
Gastrointestinal disorder	30.53	10.04	54	95778	89655	64313245
Cyanosis	30.49	10.04	87	95745	22068	64380832
Anal sphincter atony	30.29	10.04	13	95819	312	64402588
Hyponatraemia	30.00	10.04	116	95716	148223	64254677
Surgery	29.76	10.04	101	95731	28112	64374788
White blood cell count decreased	29.68	10.04	127	95705	157710	64245190
Drug ineffective	29.64	10.04	988	94844	839259	63563641
Myocardial fibrosis	29.58	10.04	22	95810	1558	64401342
Blood ethanol	29.29	10.04	10	95822	125	64402775
Impaired healing	29.22	10.04	28	95804	60445	64342455
Corneal epithelium defect	29.10	10.04	16	95816	669	64402231
Nystagmus	29.05	10.04	50	95782	9018	64393882
Spinal cord infarction	28.86	10.04	15	95817	559	64402341
Weight increased	28.31	10.04	193	95639	213155	64189745
Fall	28.06	10.04	443	95389	416383	63986517
Oedema peripheral	28.03	10.04	190	95642	210127	64192773
Product administration error	27.45	10.04	97	95735	27546	64375354
Pneumonia	27.42	10.04	628	95204	558948	63843952
Suicidal ideation	27.36	10.04	181	95651	66361	64336539
Drug withdrawal syndrome	27.05	10.04	105	95727	31186	64371714
Inhibitory drug interaction	26.90	10.04	30	95802	3597	64399303
Platelet count decreased	26.83	10.04	143	95689	167568	64235332
Myocardial infarction	26.74	10.04	141	95691	165680	64237220
Diabetes mellitus	26.46	10.04	36	95796	66438	64336462
Muscle injury	26.15	10.04	4	95828	26433	64376467
Neurotoxicity	25.38	10.04	94	95738	27310	64375590
Dysarthria	25.28	10.04	163	95669	59243	64343657
Impaired quality of life	25.23	10.04	39	95793	6432	64396468
Meningitis chemical	25.17	10.04	10	95822	196	64402704
Blood pressure fluctuation	25.09	10.04	24	95808	51847	64351053
Embolia cutis medicamentosa	25.08	10.04	13	95819	482	64402418
Blood creatinine increased	25.07	10.04	110	95722	135672	64267228
Sensory loss	24.95	10.04	50	95782	10119	64392781
Incorrect drug administration rate	24.61	10.04	25	95807	2694	64400206
Product preparation error	24.49	10.04	30	95802	3975	64398925
Platelet aggregation inhibition	24.45	10.04	9	95823	142	64402758
Pupil fixed	24.43	10.04	27	95805	3205	64399695
Loss of personal independence in daily activities	24.31	10.04	44	95788	72410	64330490
Blood ethanol increased	24.24	10.04	14	95818	644	64402256
Chemical submission	24.19	10.04	10	95822	218	64402682
Status epilepticus	24.13	10.04	79	95753	21584	64381316
Drug resistance	24.04	10.04	11	95821	35091	64367809
Type I hypersensitivity	23.87	10.04	28	95804	3546	64399354
Amphetamines positive	23.65	10.04	10	95822	231	64402669
Delayed recovery from anaesthesia	23.64	10.04	19	95813	1509	64401391
Septic shock	23.61	10.04	79	95753	105358	64297542
Pneumocephalus	23.50	10.04	10	95822	235	64402665
C-reactive protein increased	23.45	10.04	68	95764	94841	64308059
Cardiotoxicity	23.42	10.04	49	95783	10225	64392675
Melaena	23.40	10.04	27	95805	53521	64349379
Orthostatic hypotension	23.34	10.04	21	95811	46717	64356183
Parophthalmia	23.30	10.04	11	95821	332	64402568
Bronchospasm	23.20	10.04	78	95754	21604	64381296
Dehydration	23.19	10.04	208	95624	216555	64186345
Punctate keratitis	23.14	10.04	15	95817	850	64402050
Bursitis infective	23.12	10.04	17	95815	1183	64401717
Hypersensitivity	23.05	10.04	184	95648	196268	64206632
Toxicologic test abnormal	22.81	10.04	17	95815	1208	64401692
Cardiac failure	22.80	10.04	110	95722	132263	64270637
Pulmonary embolism	22.74	10.04	126	95706	146230	64256670
Wrong product administered	22.70	10.04	41	95791	7679	64395221
Anxiety	22.66	10.04	425	95407	202224	64200676
Spinal anaesthesia	22.47	10.04	7	95825	64	64402836
Upper airway obstruction	22.40	10.04	17	95815	1241	64401659
Kounis syndrome	22.40	10.04	25	95807	3000	64399900
Nerve root injury	22.37	10.04	6	95826	30	64402870
Bone marrow failure	22.25	10.04	23	95809	47929	64354971
Psoriatic arthropathy	22.15	10.04	19	95813	43262	64359638
Serotonin syndrome	22.06	10.04	116	95716	39166	64363734
Cytomegalovirus infection	22.06	10.04	14	95818	37185	64365715
Peripheral nerve injury	22.03	10.04	13	95819	623	64402277
Behaviour disorder	21.92	10.04	30	95802	4432	64398468
Psoriasis	21.92	10.04	46	95786	71657	64331243
Hyperkalaemia	21.81	10.04	77	95755	101052	64301848
Alcohol intolerance	21.75	10.04	11	95821	387	64402513
Pneumocystis jirovecii pneumonia	21.68	10.04	7	95825	27627	64375273
Victim of sexual abuse	21.52	10.04	11	95821	396	64402504
Amnesia	21.50	10.04	134	95698	48135	64354765
Neuromuscular block prolonged	21.48	10.04	15	95817	962	64401938
Treatment failure	21.34	10.04	95	95737	116721	64286179
Bezoar	21.31	10.04	21	95811	2182	64400718
Atonic urinary bladder	21.07	10.04	7	95825	80	64402820
Headache	20.92	10.04	613	95219	528854	63874046
Therapeutic product effect incomplete	20.87	10.04	81	95751	103401	64299499
Gastrointestinal haemorrhage	20.50	10.04	114	95718	132198	64270702
Blood pressure systolic increased	20.48	10.04	26	95806	49427	64353473
Product contamination microbial	20.46	10.04	14	95818	869	64402031
Withdrawal syndrome	20.45	10.04	79	95753	23413	64379487
Pupillary reflex impaired	20.40	10.04	24	95808	3049	64399851
Eosinophilia	20.38	10.04	16	95816	38060	64364840
Asthma	20.20	10.04	73	95759	95152	64307748
Liver disorder	20.13	10.04	30	95802	53321	64349579
Glucose tolerance impaired	19.95	10.04	35	95797	6408	64396492
Disease recurrence	19.89	10.04	11	95821	31499	64371401
Hepatic function abnormal	19.88	10.04	41	95791	64272	64338628
Substance dependence	19.60	10.04	11	95821	479	64402421
Ventricular extrasystoles	19.59	10.04	64	95768	17465	64385435
Hepatocellular injury	19.56	10.04	23	95809	45212	64357688
Underdose	19.47	10.04	7	95825	25822	64377078
Angina pectoris	19.41	10.04	23	95809	45058	64357842
Protein C increased	19.40	10.04	7	95825	104	64402796
Sensorimotor disorder	19.39	10.04	13	95819	780	64402120
Nasal congestion	19.33	10.04	37	95795	59621	64343279
Gastroenteritis	19.30	10.04	10	95822	29701	64373199
Cholestasis	19.20	10.04	23	95809	44849	64358051
Harlequin syndrome	19.06	10.04	6	95826	57	64402843
Electrocardiogram QT prolonged	18.98	10.04	191	95641	79257	64323643
Glossoptosis	18.88	10.04	8	95824	186	64402714
Multiple sclerosis relapse	18.79	10.04	20	95812	41115	64361785
Myelosuppression	18.76	10.04	6	95826	23824	64379076
Infusion site swelling	18.65	10.04	31	95801	5434	64397466
Product prescribing error	18.65	10.04	15	95817	35254	64367646
Type 2 diabetes mellitus	18.58	10.04	14	95818	34006	64368894
Peritonitis	18.50	10.04	7	95825	25016	64377884
Hepatic fibrosis	18.29	10.04	31	95801	5521	64397379
Tracheal deviation	18.27	10.04	6	95826	66	64402834
Pulmonary fibrosis	18.05	10.04	11	95821	29867	64373033
Blister	17.89	10.04	61	95771	80906	64321994
Cardiogenic shock	17.69	10.04	95	95737	32332	64370568
Phrenic nerve paralysis	17.63	10.04	8	95824	220	64402680
Restlessness	17.44	10.04	110	95722	39675	64363225
Arthritis bacterial	17.42	10.04	37	95795	7802	64395098
Catecholamine crisis	17.35	10.04	5	95827	34	64402866
Spinal epidural haemorrhage	17.17	10.04	7	95825	147	64402753
Brain death	17.17	10.04	28	95804	4833	64398067
Intracranial hypotension	17.04	10.04	9	95823	347	64402553
Foreign body in respiratory tract	17.04	10.04	9	95823	347	64402553
Lung disorder	16.88	10.04	41	95791	60659	64342241
Myoclonus	16.83	10.04	78	95754	25040	64377860
Substance use disorder	16.78	10.04	9	95823	358	64402542
Balance disorder	16.72	10.04	66	95766	83860	64319040
Infusion site pruritus	16.71	10.04	20	95812	2586	64400314
Impaired driving ability	16.70	10.04	27	95805	4627	64398273
Coronary artery disease	16.66	10.04	41	95791	60392	64342508
Retinal artery occlusion	16.55	10.04	21	95811	2882	64400018
Osteonecrosis of jaw	16.43	10.04	21	95811	39804	64363096
Neutropenic sepsis	16.40	10.04	7	95825	23265	64379635
Application site alopecia	16.29	10.04	4	95828	13	64402887
Axillary nerve injury	16.29	10.04	4	95828	13	64402887
Blood cholesterol increased	16.26	10.04	31	95801	50035	64352865
Hypocalcaemia	16.22	10.04	23	95809	41730	64361170
Spinal epidural haematoma	16.22	10.04	14	95818	1228	64401672
Somnambulism	16.01	10.04	28	95804	5113	64397787
Delirium	15.89	10.04	165	95667	69029	64333871
Foreign body	15.86	10.04	19	95813	2460	64400440
Influenza	15.85	10.04	93	95739	106438	64296462
Hypercalcaemia	15.82	10.04	14	95818	31402	64371498
Stridor	15.78	10.04	27	95805	4847	64398053
Neuropathy peripheral	15.73	10.04	106	95726	117419	64285481
Induced abortion failed	15.72	10.04	7	95825	184	64402716
Euphoric mood	15.69	10.04	32	95800	6559	64396341
Red blood cell count decreased	15.68	10.04	30	95802	48356	64354544
Red blood cell sedimentation rate increased	15.64	10.04	14	95818	31221	64371679
Stomatitis	15.62	10.04	97	95735	109508	64293392
Neoplasm progression	15.49	10.04	23	95809	40941	64361959
Ill-defined disorder	15.46	10.04	26	95806	44026	64358874
Paralysis	15.44	10.04	45	95787	11550	64391350
Brachial plexus injury	15.42	10.04	6	95826	111	64402789
Diabetic ketoacidosis	15.40	10.04	13	95819	29832	64373068
Haemodynamic instability	15.39	10.04	53	95779	14859	64388041
Substance-induced mood disorder	15.32	10.04	6	95826	113	64402787
Stevens-Johnson syndrome	15.25	10.04	17	95815	34232	64368668
Anaphylactoid shock	15.25	10.04	11	95821	743	64402157
Inappropriate antidiuretic hormone secretion	15.24	10.04	7	95825	22282	64380618
Injection site bruising	15.19	10.04	19	95813	36354	64366546
Chest pain	15.11	10.04	253	95579	235727	64167173
Lymphadenopathy	15.08	10.04	29	95803	46657	64356243
Chemical burn	14.94	10.04	9	95823	448	64402452
Jaundice	14.93	10.04	31	95801	48481	64354419
Trigeminal palsy	14.92	10.04	4	95828	20	64402880
Incision site rash	14.92	10.04	4	95828	20	64402880
Post procedural complication	14.82	10.04	67	95765	21286	64381614
Nail bed tenderness	14.74	10.04	8	95824	326	64402574
Infection	14.69	10.04	190	95642	184690	64218210
Dyspnoea exertional	14.68	10.04	58	95774	73672	64329228
Transient ischaemic attack	14.67	10.04	27	95805	44155	64358745
Brain injury	14.56	10.04	40	95792	9925	64392975
Osteoarthritis	14.49	10.04	47	95785	63289	64339611
Mean arterial pressure decreased	14.41	10.04	8	95824	341	64402559
Accidental poisoning	14.33	10.04	14	95818	1439	64401461
Spinal cord oedema	14.30	10.04	8	95824	346	64402554
Ventricular hypokinesia	14.28	10.04	34	95798	7735	64395165
Injection site reaction	14.21	10.04	30	95802	46634	64356266
Intentional dose omission	14.12	10.04	28	95804	5624	64397276
Dizziness	14.11	10.04	510	95322	429653	63973247
Injection site ulcer	14.11	10.04	10	95822	657	64402243
Opisthotonus	14.05	10.04	10	95822	661	64402239
Inappropriate schedule of product administration	14.03	10.04	80	95752	92206	64310694
Gait disturbance	14.02	10.04	176	95656	171979	64230921
Neuromuscular blockade	13.97	10.04	9	95823	505	64402395
Vitreous disorder	13.93	10.04	7	95825	243	64402657
Angina unstable	13.88	10.04	3	95829	15464	64387436
Nerve block	13.87	10.04	8	95824	367	64402533
Gastrooesophageal reflux disease	13.79	10.04	70	95762	83073	64319827
Oxidative stress	13.78	10.04	4	95828	28	64402872
Foetal heart rate abnormal	13.77	10.04	7	95825	249	64402651
Blindness	13.75	10.04	67	95765	21952	64380948
Anaphylactoid reaction	13.72	10.04	25	95807	4713	64398187
Accident	13.72	10.04	31	95801	6815	64396085
Body dysmorphic disorder	13.69	10.04	7	95825	252	64402648
Abdominal distension	13.65	10.04	85	95747	95909	64306991
Familial periodic paralysis	13.64	10.04	6	95826	153	64402747
Infusion site erythema	13.64	10.04	31	95801	6842	64396058
Physical assault	13.60	10.04	14	95818	1532	64401368
Gastric disorder	13.55	10.04	14	95818	29183	64373717
Injection site joint infection	13.54	10.04	4	95828	30	64402870
Anal ulcer	13.47	10.04	12	95820	1097	64401803
Poor quality product administered	13.42	10.04	20	95812	3195	64399705
Prescribed underdose	13.38	10.04	5	95827	18010	64384890
Skin lesion	13.30	10.04	21	95811	36461	64366439
Cholestasis of pregnancy	13.25	10.04	11	95821	914	64401986
Adverse event	13.23	10.04	24	95808	39465	64363435
Product use issue	13.16	10.04	153	95679	151562	64251338
Visual acuity reduced	13.14	10.04	77	95755	27064	64375836
Apnoeic attack	13.10	10.04	9	95823	562	64402338
Pulmonary congestion	13.05	10.04	70	95762	23810	64379090
Deep vein thrombosis	13.04	10.04	97	95735	105085	64297815
Gastritis alcoholic	13.00	10.04	4	95828	35	64402865
Symblepharon	12.96	10.04	6	95826	173	64402727
COVID-19 immunisation	12.96	10.04	9	95823	572	64402328
International normalised ratio increased	12.93	10.04	67	95765	79100	64323800
Abortion spontaneous	12.91	10.04	11	95821	25132	64377768
Reperfusion arrhythmia	12.90	10.04	7	95825	285	64402615
Metastases to liver	12.89	10.04	10	95822	23931	64378969
Ascites	12.84	10.04	48	95784	61953	64340947
Hypoxic-ischaemic encephalopathy	12.82	10.04	31	95801	7121	64395779
Lung neoplasm malignant	12.81	10.04	8	95824	21440	64381460
Alcoholic	12.80	10.04	4	95828	37	64402863
Constipation	12.76	10.04	252	95580	229085	64173815
Skin exfoliation	12.73	10.04	30	95802	44855	64358045
Infusion site mass	12.69	10.04	11	95821	970	64401930
Femoral nerve injury	12.52	10.04	4	95828	40	64402860
Psychiatric disorder prophylaxis	12.52	10.04	4	95828	40	64402860
Abnormal sleep-related event	12.35	10.04	10	95822	803	64402097
Left ventricle outflow tract obstruction	12.32	10.04	7	95825	312	64402588
Irritable bowel syndrome	12.26	10.04	23	95809	37346	64365554
Accidental exposure to product	12.25	10.04	74	95758	26290	64376610
Progressive multifocal leukoencephalopathy	12.05	10.04	6	95826	18226	64384674
Airway peak pressure increased	11.96	10.04	7	95825	330	64402570
Full blood count abnormal	11.95	10.04	16	95816	29741	64373159
Myelodysplastic syndrome	11.95	10.04	14	95818	27565	64375335
Infusion site bruising	11.93	10.04	13	95819	1519	64401381
Myokymia	11.93	10.04	5	95827	113	64402787
Eczema	11.92	10.04	16	95816	29704	64373196
Benzodiazepine drug level therapeutic	11.87	10.04	4	95828	48	64402852
Obesity	11.83	10.04	8	95824	20554	64382346
Paranasal cyst	11.83	10.04	7	95825	337	64402563
Discomfort	11.82	10.04	71	95761	80807	64322093
Non-cardiogenic pulmonary oedema	11.79	10.04	12	95820	1296	64401604
Graft versus host disease	11.76	10.04	3	95829	13810	64389090
Pain in jaw	11.75	10.04	27	95805	40728	64362172
Vascular resistance systemic decreased	11.74	10.04	6	95826	216	64402684
Blood lactic acid increased	11.65	10.04	38	95794	10363	64392537
Cardiac death	11.64	10.04	12	95820	1316	64401584
Stab wound	11.61	10.04	6	95826	221	64402679
Congestive hepatopathy	11.55	10.04	21	95811	3952	64398948
Areflexia	11.55	10.04	24	95808	4983	64397917
Bundle branch block left	11.54	10.04	37	95795	9997	64392903
Inadequate analgesia	11.54	10.04	21	95811	3957	64398943
Procedural complication	11.46	10.04	30	95802	7235	64395665
Administration related reaction	11.43	10.04	5	95827	126	64402774
Corneal opacity	11.41	10.04	10	95822	895	64402005
Acute myocardial infarction	11.39	10.04	59	95773	69659	64333241
Poor quality sleep	11.36	10.04	57	95775	18894	64384006
Diabetes mellitus inadequate control	11.36	10.04	9	95823	21312	64381588
Chest discomfort	11.30	10.04	114	95718	115992	64286908
Osteoporosis	11.25	10.04	29	95803	42051	64360849
Drug eruption	11.20	10.04	23	95809	36113	64366787
Coccygectomy	11.19	10.04	3	95829	15	64402885
Sinus arrest	11.19	10.04	18	95814	3072	64399828
Myalgia	11.17	10.04	167	95665	158450	64244450
Immunodeficiency	11.13	10.04	5	95827	16119	64386781
Sinus bradycardia	11.11	10.04	65	95767	22828	64380072
Feeling abnormal	11.10	10.04	136	95696	133466	64269434
Acute pulmonary oedema	11.08	10.04	43	95789	12766	64390134
Glycosylated haemoglobin increased	11.00	10.04	5	95827	16014	64386886
Cerebral haemorrhage	10.94	10.04	39	95793	51051	64351849
Fatty liver alcoholic	10.93	10.04	4	95828	62	64402838
Paraplegia	10.92	10.04	22	95810	4468	64398432
Rash pruritic	10.90	10.04	46	95786	57358	64345542
Infusion site nodule	10.89	10.04	6	95826	252	64402648
Throat irritation	10.85	10.04	20	95812	32691	64370209
Palpitations	10.84	10.04	101	95731	104387	64298513
Postmortem blood drug level increased	10.80	10.04	9	95823	752	64402148
Repetitive strain injury	10.74	10.04	5	95827	146	64402754
Gait inability	10.72	10.04	30	95802	42338	64360562
Suicidal behaviour	10.70	10.04	17	95815	2870	64400030
Air embolism	10.67	10.04	7	95825	405	64402495
Renal impairment	10.63	10.04	139	95693	134878	64268022
Sopor	10.61	10.04	78	95754	29583	64373317
Haematotoxicity	10.60	10.04	3	95829	12893	64390007
Infusion site extravasation	10.55	10.04	28	95804	6809	64396091
Procedural haemorrhage	10.54	10.04	21	95811	4231	64398669
Orbital infection	10.49	10.04	4	95828	70	64402830
Gastric ulcer	10.46	10.04	18	95814	30216	64372684
Suspected suicide attempt	10.45	10.04	6	95826	273	64402627
Upper gastrointestinal haemorrhage	10.43	10.04	23	95809	35197	64367703
Breast cancer	10.42	10.04	17	95815	29131	64373769
Irregular breathing	10.38	10.04	7	95825	424	64402476
Full blood count decreased	10.29	10.04	11	95821	22571	64380329
Anticholinergic syndrome	10.29	10.04	16	95816	2653	64400247
Hypercholesterolaemia	10.25	10.04	5	95827	15368	64387532
Cholelithiasis	10.25	10.04	34	95798	45472	64357428
Oesophageal obstruction	10.23	10.04	9	95823	810	64402090
Chemical poisoning	10.21	10.04	5	95827	164	64402736
Amaurosis	10.19	10.04	10	95822	1034	64401866
Coma scale abnormal	10.19	10.04	30	95802	7744	64395156
Hip arthroplasty	10.18	10.04	10	95822	21341	64381559
Tubulointerstitial nephritis	10.16	10.04	19	95813	30890	64372010
Tracheitis	10.14	10.04	11	95821	1279	64401621
Metastases to lung	10.12	10.04	5	95827	15259	64387641
Immune reconstitution inflammatory syndrome	10.07	10.04	3	95829	12467	64390433
Oropharyngeal pain	10.06	10.04	84	95748	88783	64314117
Alcoholic pancreatitis	10.04	10.04	5	95827	170	64402730

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	55.01	20.06	9	4	68	84597

Pharmacologic Action:

Source	Code	Description
ATC	D08AJ01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds
ATC	D09AA05	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	D09AA11	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	R02AA16	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
CHEBI has role	CHEBI:27780	Detergents
CHEBI has role	CHEBI:33282	bactericides
CHEBI has role	CHEBI:35195	surfactant
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D003902	Detergents
MeSH PA	D010592	Pharmaceutic Aids
MeSH PA	D011310	Preservatives, Pharmaceutical
MeSH PA	D013501	Surface-Active Agents
CHEBI has role	CHEBI:51076	Marine pesticide

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Uveitis	indication	128473001	DOID:13141
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Allergic otitis externa	indication	405821001
Itching of skin	indication	418363000
Itching of ear	indication	699392007
Post-Op Ocular Inflammation	indication
Suppression of the Gag Reflex	indication
Mouth Irritation	indication
Prevent Minor Bacterial Skin Infection	indication
Minor Skin Wound Pain	indication
Bacterial septicemia	contraindication	10001005	DOID:0040085
Hypocupremia	contraindication	19577007
Infection of skin AND/OR subcutaneous tissue	contraindication	19824006
Shock	contraindication	27942005
Methemoglobinemia	contraindication	38959009	DOID:10783
Conduction disorder of the heart	contraindication	44808001
Perforation of tympanic membrane	contraindication	60442001
Diabetes mellitus	contraindication	73211009	DOID:9351
Decreased respiratory function	contraindication	80954004
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Deficiency of cytochrome-b>5< reductase	contraindication	124184009
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Heart block	contraindication	233916004
Disease of liver	contraindication	235856003	DOID:409
Condyloma acuminatum	contraindication	240542006	DOID:11168
Peripheral vascular disease	contraindication	400047006
Blister	contraindication	417237009
Denuded skin	contraindication	418242004
Inflammatory dermatosis	contraindication	703938007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018249	VUID
N0000178890	NUI
D00857	KEGG_DRUG
8001-54-5	SECONDARY_CAS_RN
4018249	VANDF
4023321	VANDF
C0005025	UMLSCUI
CHEBI:3020	CHEBI
CHEMBL1187417	ChEMBL_ID
CHEMBL502109	ChEMBL_ID
CHEMBL1907001	ChEMBL_ID
D001548	MESH_DESCRIPTOR_UI
DB11105	DRUGBANK_ID
7N6JUD5X6Y	UNII
2330	PUBCHEM_CID
DB13282	DRUGBANK_ID
1311593	RXNORM
4255	MMSL
5003	MMSL
003141	NDDF
005466	NDDF
006369	NDDF
373549009	SNOMEDCT_US
64686009	SNOMEDCT_US
735078001	SNOMEDCT_US
90370005	SNOMEDCT_US
1168	INN_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Stay Safe Hand Sanitizer Alcohol Free	HUMAN OTC DRUG LABEL	1	0295-9049	GEL	0.13 mg	TOPICAL	OTC monograph not final	10 sections
Hand wash	HUMAN OTC DRUG LABEL	1	0363-0082	SOAP	1.30 mg	TOPICAL	OTC monograph not final	11 sections
Walgreen	HUMAN OTC DRUG LABEL	1	0363-0242	SOAP	130 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	1.30 mg	TOPICAL	OTC monograph not final	10 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	1.30 mg	TOPICAL	OTC monograph not final	10 sections
Nicefresh scent	HUMAN OTC DRUG LABEL	1	0363-0554	CLOTH	0.12 g	TOPICAL	OTC monograph not final	11 sections
First Aid Antiseptic Wipes	HUMAN OTC DRUG LABEL	1	0363-0589	CLOTH	0.00 mg	TOPICAL	OTC monograph not final	11 sections
First Aid Antiseptic Wipes	HUMAN OTC DRUG LABEL	1	0363-0589	CLOTH	0.00 mg	TOPICAL	OTC monograph not final	11 sections
4x Medicated Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	0363-0607	CREAM	0.13 g	ORAL	OTC monograph not final	9 sections
Hand wipes	HUMAN OTC DRUG LABEL	1	0363-0644	CLOTH	1.30 g	TOPICAL	OTC monograph not final	12 sections
Hand wipes	HUMAN OTC DRUG LABEL	1	0363-0644	CLOTH	1.30 g	TOPICAL	OTC monograph not final	12 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0651	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0651	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0683	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	11 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0683	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	11 sections
First Aid AntisepticWell at Walgreens	HUMAN OTC DRUG LABEL	2	0363-3286	SPRAY	0.13 g	TOPICAL	OTC monograph not final	11 sections
4x Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	4	0363-6008	GEL	0.13 g	ORAL	OTC monograph not final	9 sections
Walgreen Maximum strengthpain relieving cleansing	HUMAN OTC DRUG LABEL	2	0363-7020	LIQUID	0.13 g	TOPICAL	OTC monograph not final	14 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	0363-7110	LIQUID	1.25 g	TOPICAL	OTC monograph not final	11 sections
STUDIO 35 BEAUTYAMBER ANTIBACTERIAL REFILL	HUMAN OTC DRUG LABEL	1	0363-7210	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
WalgreensANTIBACTERIAL HAND REFILL	HUMAN OTC DRUG LABEL	1	0363-7211	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
STUDIO 35AMBER	HUMAN OTC DRUG LABEL	1	0363-7215	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Antiseptic Pain Relieving	HUMAN OTC DRUG LABEL	2	0363-7779	SPRAY	0.10 g	TOPICAL	OTC monograph not final	7 sections
Walgreens	HUMAN OTC DRUG LABEL	2	0363-7950	SPRAY	0.13 g	TOPICAL	OTC monograph not final	12 sections
Walgreens Fresh Antibacterial Foaming Hand	HUMAN OTC DRUG LABEL	1	0363-9000	SOAP	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens Citrus Antibacterial Foaming Hand	HUMAN OTC DRUG LABEL	1	0363-9002	SOAP	1.30 mg	TOPICAL	OTC monograph not final	12 sections
HUMCO Merthiolate	HUMAN OTC DRUG LABEL	1	0395-8010	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	13 sections
HUMCO Merthiolate	HUMAN OTC DRUG LABEL	1	0395-8010	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	13 sections
Merthiolate	HUMAN OTC DRUG LABEL	1	0395-9122	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0404-4445	LIQUID	7.49 g	TOPICAL	OTC monograph not final	11 sections