benzalkonium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3017	139-07-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzalkonium chloride benzalkonium benzyldodecyldimethylammonium chloride benzododecinium	A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics. Molecular weight: 304.54 Formula: C21H38N CLOGP: 3.18 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: ALOGS: -7.85 ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	2402.18	10.22	1744	56425	144176	46483717
Toxicity to various agents	1686.93	10.22	1667	56502	210099	46417794
Drug abuse	567.21	10.22	534	57635	62874	46565019
Cardio-respiratory arrest	533.17	10.22	503	57666	59366	46568527
Intentional overdose	504.03	10.22	506	57663	64438	46563455
Overdose	374.23	10.22	543	57626	101436	46526457
Alcohol interaction	280.50	10.22	108	58061	2337	46625556
Cardiac arrest	275.86	10.22	442	57727	89957	46537936
Suicide attempt	275.17	10.22	341	57828	54695	46573198
Methaemoglobinaemia	187.27	10.22	78	58091	2084	46625809
Alcohol poisoning	167.24	10.22	73	58096	2195	46625698
Suspected suicide	157.07	10.22	88	58081	4573	46623320
Local anaesthetic systemic toxicity	151.60	10.22	43	58126	335	46627558
Toxic anterior segment syndrome	135.86	10.22	62	58107	2075	46625818
Alcohol use	134.03	10.22	64	58105	2378	46625515
Respiratory arrest	133.99	10.22	187	57982	33629	46594264
Intentional product misuse	120.38	10.22	213	57956	46915	46580978
Rheumatoid arthritis	116.83	10.22	78	58091	240137	46387756
Alcohol abuse	104.42	10.22	52	58117	2120	46625773
Death	94.12	10.22	727	57442	334821	46293072
Anaesthetic complication	88.83	10.22	44	58125	1773	46626120
Therapy interrupted	83.39	10.22	84	58085	10707	46617186
Incorrect route of product administration	80.96	10.22	101	58068	16282	46611611
Coma	76.25	10.22	201	57968	58148	46569745
Sinusitis	71.72	10.22	336	57833	129432	46498461
Diarrhoea	68.66	10.22	413	57756	559189	46068704
Generalised tonic-clonic seizure	67.20	10.22	121	58048	27001	46600892
Pulseless electrical activity	67.09	10.22	62	58107	7105	46620788
Somnolence	66.80	10.22	377	57792	156144	46471749
Ventricular tachycardia	65.96	10.22	93	58076	16874	46611019
Seizure	62.49	10.22	311	57858	122743	46505150
Mydriasis	61.91	10.22	71	58098	10482	46617411
Anaphylactic shock	58.82	10.22	97	58072	20177	46607716
Anaphylactic reaction	54.78	10.22	168	58001	52944	46574949
Unresponsive to stimuli	53.93	10.22	122	58047	32052	46595841
Drug ineffective	53.12	10.22	565	57604	677273	45950620
Drug intolerance	53.09	10.22	63	58106	146986	46480907
Maternal exposure during delivery	52.90	10.22	24	58145	792	46627101
General physical health deterioration	51.76	10.22	41	58128	115728	46512165
Blood alcohol increased	51.67	10.22	23	58146	725	46627168
Arthralgia	51.22	10.22	257	57912	364346	46263547
Loss of consciousness	47.66	10.22	263	57906	107975	46519918
Hypotension	46.86	10.22	469	57700	232120	46395773
Alopecia	46.41	10.22	82	58087	162332	46465561
Infusion site swelling	45.20	10.22	45	58124	5654	46622239
Alcoholism	44.31	10.22	30	58139	2188	46625705
Infusion site erythema	42.46	10.22	50	58119	7592	46620301
Pemphigus	41.85	10.22	4	58165	45270	46582623
Contraindicated product administered	41.50	10.22	24	58145	79923	46547970
Procedural hypotension	41.33	10.22	23	58146	1179	46626714
Lagophthalmos	41.00	10.22	15	58154	280	46627613
Poisoning deliberate	40.99	10.22	50	58119	7876	46620017
Pulse absent	40.92	10.22	40	58129	4916	46622977
Asthenia	39.91	10.22	226	57943	310849	46317044
Bradycardia	39.81	10.22	176	57993	66122	46561771
Corneal oedema	39.57	10.22	25	58144	1621	46626272
Joint swelling	38.86	10.22	94	58075	165979	46461914
Respiratory depression	38.46	10.22	59	58110	11541	46616352
Body tinea	38.03	10.22	20	58149	915	46626978
Tachycardia	37.96	10.22	233	57936	99389	46528504
Agitation	37.85	10.22	153	58016	55262	46572631
Exposure to toxic agent	37.30	10.22	26	58143	1988	46625905
Infusion site pruritus	37.10	10.22	31	58138	3107	46624786
Mental status changes	36.08	10.22	117	58052	37971	46589922
Ventricular fibrillation	36.07	10.22	57	58112	11439	46616454
Abdominal discomfort	35.81	10.22	85	58084	151080	46476813
Victim of sexual abuse	35.15	10.22	16	58153	532	46627361
Substance abuse	35.09	10.22	34	58135	4133	46623760
Retinal vasculitis	35.02	10.22	17	58152	655	46627238
Administration site pain	34.90	10.22	17	58152	660	46627233
Anaesthetic complication neurological	34.74	10.22	12	58157	188	46627705
Bursitis infective	33.73	10.22	20	58149	1157	46626736
Fear	33.67	10.22	67	58102	16105	46611788
Postmortem blood drug level abnormal	32.39	10.22	13	58156	315	46627578
Synovitis	32.18	10.22	18	58151	61057	46566836
Systemic lupus erythematosus	31.84	10.22	21	58148	65159	46562734
Parophthalmia	31.72	10.22	12	58157	247	46627646
Corneal epithelium defect	31.61	10.22	13	58156	336	46627557
Fear of eating	31.57	10.22	13	58156	337	46627556
Aggression	31.39	10.22	80	58089	22664	46605229
Anterior chamber cell	31.34	10.22	15	58154	560	46627333
Sinus tachycardia	30.76	10.22	77	58092	21572	46606321
Stress cardiomyopathy	30.75	10.22	43	58126	7741	46620152
Infusion site pain	30.18	10.22	49	58120	10058	46617835
Pneumocephalus	29.86	10.22	10	58159	142	46627751
Electrocardiogram ST segment elevation	28.98	10.22	29	58140	3666	46624227
Cough	28.57	10.22	169	58000	230080	46397813
Infusion site extravasation	28.56	10.22	34	58135	5222	46622671
Renal injury	28.14	10.22	46	58123	9495	46618398
Ophthalmoplegia	27.89	10.22	16	58153	870	46627023
Platelet aggregation inhibition	27.74	10.22	9	58160	115	46627778
Cardiac failure congestive	27.40	10.22	45	58124	91705	46536188
Type I hypersensitivity	27.37	10.22	23	58146	2323	46625570
Gastrointestinal toxicity	26.87	10.22	30	58139	4301	46623592
Acute kidney injury	26.74	10.22	178	57991	235677	46392216
Glossodynia	26.54	10.22	11	58158	44362	46583531
Administration site swelling	26.28	10.22	17	58152	1148	46626745
Pancytopenia	26.08	10.22	41	58128	85017	46542876
Arthritis	25.93	10.22	35	58134	77281	46550612
Kounis syndrome	25.80	10.22	17	58152	1185	46626708
Sensory loss	25.60	10.22	37	58132	6865	46621028
Neutropenia	24.89	10.22	93	58076	143111	46484782
Spinal epidural haemorrhage	24.67	10.22	8	58161	102	46627791
Depressed level of consciousness	24.66	10.22	121	58048	47448	46580445
Anaemia	24.25	10.22	203	57966	255576	46372317
Anhedonia	24.19	10.22	45	58124	10290	46617603
Peripheral nerve injury	24.16	10.22	11	58158	366	46627527
Neurotoxicity	24.09	10.22	53	58116	13664	46614229
Cyanosis	23.96	10.22	58	58111	15913	46611980
Apnoea	23.87	10.22	37	58132	7302	46620591
Hepatic enzyme increased	23.61	10.22	41	58128	81746	46546147
Meningitis chemical	23.24	10.22	8	58161	124	46627769
Extradural haematoma	23.20	10.22	17	58152	1406	46626487
Decreased appetite	23.13	10.22	144	58025	193692	46434201
Septic arthritis staphylococcal	23.10	10.22	11	58158	406	46627487
Electrocardiogram QRS complex prolonged	22.87	10.22	31	58138	5418	46622475
Infection susceptibility increased	22.66	10.22	20	58149	2159	46625734
Miosis	22.27	10.22	34	58135	6623	46621270
Unevaluable event	22.21	10.22	115	58054	46060	46581833
Psoriasis	22.15	10.22	40	58129	78564	46549329
Electrocardiogram QT prolonged	22.09	10.22	124	58045	51201	46576692
Punctate keratitis	22.00	10.22	12	58157	591	46627302
Leukopenia	21.86	10.22	32	58137	68311	46559582
Spinal anaesthesia	21.84	10.22	6	58163	41	46627852
Atonic urinary bladder	21.75	10.22	7	58162	87	46627806
Pulmonary toxicity	21.71	10.22	28	58141	4665	46623228
Somnambulism	21.67	10.22	29	58140	5008	46622885
C-reactive protein increased	21.23	10.22	25	58144	58565	46569328
Intentional product use issue	21.08	10.22	125	58044	52655	46575238
Weight decreased	21.05	10.22	165	58004	210684	46417209
Glossoptosis	20.80	10.22	6	58163	50	46627843
Injury	20.73	10.22	109	58060	43918	46583975
Therapeutic product effect decreased	20.72	10.22	45	58124	82556	46545337
Product adhesion issue	20.51	10.22	28	58141	4927	46622966
Upper airway obstruction	20.41	10.22	11	58158	529	46627364
Nystagmus	20.34	10.22	30	58139	5669	46622224
Disease progression	20.31	10.22	53	58116	91247	46536646
Thrombocytopenia	20.22	10.22	85	58084	126496	46501397
Incorrect drug administration rate	20.14	10.22	18	58151	1975	46625918
Inhibitory drug interaction	20.13	10.22	18	58151	1977	46625916
Dyspnoea	19.90	10.22	490	57679	515058	46112835
Fall	19.72	10.22	290	57879	328807	46299086
Drug level increased	19.63	10.22	59	58110	18382	46609511
Homicide	19.46	10.22	10	58159	436	46627457
Accidental death	19.40	10.22	17	58152	1818	46626075
Therapy cessation	19.36	10.22	75	58094	26554	46601339
Off label use	19.35	10.22	345	57824	379496	46248397
Spinal epidural haematoma	19.02	10.22	12	58157	776	46627117
Abdominal pain upper	18.89	10.22	105	58064	145200	46482693
Infusion site nodule	18.80	10.22	13	58156	981	46626912
Mobility decreased	18.77	10.22	29	58140	60565	46567328
Drug dependence	18.72	10.22	61	58108	19840	46608053
Chemical submission	18.22	10.22	8	58161	244	46627649
Drug withdrawal syndrome	18.21	10.22	75	58094	27309	46600584
Drug reaction with eosinophilia and systemic symptoms	18.20	10.22	7	58162	29541	46598352
Emotional distress	18.03	10.22	81	58088	30626	46597267
Shock	17.95	10.22	64	58105	21781	46606112
Body dysmorphic disorder	17.74	10.22	7	58162	162	46627731
Drug interaction	17.64	10.22	353	57816	202741	46425152
Abortion spontaneous	17.63	10.22	17	58152	43629	46584264
Neuromuscular block prolonged	17.56	10.22	10	58159	536	46627357
Interstitial lung disease	17.51	10.22	25	58144	53924	46573969
Protein C increased	17.50	10.22	7	58162	168	46627725
Removal of foreign body	17.23	10.22	4	58165	12	46627881
Hypocalcaemia	17.08	10.22	6	58163	26779	46601114
Drug use disorder	17.06	10.22	19	58150	2716	46625177
Poisoning	17.05	10.22	47	58122	13947	46613946
Hyponatraemia	16.83	10.22	67	58102	101265	46526628
Product dose omission issue	16.75	10.22	132	58037	168388	46459505
Pulmonary embolism	16.68	10.22	74	58095	108511	46519382
Fatigue	16.43	10.22	607	57562	608090	46019803
Ventricular extrasystoles	16.41	10.22	40	58129	11023	46616870
Peritonitis	16.36	10.22	3	58166	20711	46607182
Amnesia	16.24	10.22	98	58071	41533	46586360
Administration site extravasation	16.23	10.22	10	58159	620	46627273
Impaired quality of life	16.03	10.22	20	58149	3222	46624671
Myocarditis	16.03	10.22	32	58137	7707	46620186
Respiratory acidosis	15.96	10.22	28	58141	6120	46621773
Genital rash	15.93	10.22	9	58160	475	46627418
Haemoglobin decreased	15.79	10.22	95	58074	128854	46499039
Substance dependence	15.78	10.22	7	58162	219	46627674
Trigeminal palsy	15.61	10.22	4	58165	20	46627873
Incision site rash	15.61	10.22	4	58165	20	46627873
Areflexia	15.52	10.22	19	58150	3004	46624889
Delirium	15.40	10.22	89	58080	37139	46590754
Anal sphincter atony	15.37	10.22	7	58162	233	46627660
Alcoholic	15.33	10.22	5	58164	65	46627828
Status epilepticus	15.14	10.22	45	58124	13934	46613959
Infusion site haemorrhage	15.13	10.22	16	58153	2158	46625735
Drug hypersensitivity	14.88	10.22	214	57955	243611	46384282
Orbital infection	14.86	10.22	4	58165	25	46627868
Anaphylactoid reaction	14.86	10.22	20	58149	3471	46624422
Hypoxia	14.82	10.22	113	58056	51725	46576168
Rash	14.79	10.22	335	57834	356177	46271716
Wound	14.73	10.22	19	58150	42783	46585110
Infusion site urticaria	14.70	10.22	10	58159	735	46627158
Induced abortion failed	14.58	10.22	7	58162	263	46627630
Gastroenteritis	14.49	10.22	6	58163	24213	46603680
Intentional self-injury	14.38	10.22	64	58105	24102	46603791
Conjunctival oedema	14.35	10.22	9	58160	576	46627317
Administration site erythema	14.34	10.22	9	58160	577	46627316
Condition aggravated	14.29	10.22	217	57952	244835	46383058
Femur fracture	14.27	10.22	15	58154	36982	46590911
Propionibacterium infection	14.23	10.22	4	58165	30	46627863
Dissociative amnesia	14.23	10.22	4	58165	30	46627863
Anorgasmia	14.17	10.22	9	58160	589	46627304
Septic shock	14.14	10.22	32	58137	57861	46570032
Liver injury	14.12	10.22	48	58121	15953	46611940
Cholestasis	14.06	10.22	8	58161	26885	46601008
Eye infarction	14.01	10.22	4	58165	32	46627861
Airway peak pressure increased	13.97	10.22	7	58162	289	46627604
Pulmonary oedema	13.83	10.22	110	58059	50995	46576898
Osteoarthritis	13.79	10.22	36	58133	61989	46565904
Anaphylactoid shock	13.78	10.22	7	58162	298	46627595
Psoriatic arthropathy	13.75	10.22	15	58154	36364	46591529
Asthma	13.69	10.22	63	58106	91479	46536414
Harlequin syndrome	13.49	10.22	4	58165	37	46627856
Cardiogenic shock	13.46	10.22	48	58121	16336	46611557
Arthritis bacterial	13.46	10.22	25	58144	5711	46622182
Congenital umbilical hernia	13.38	10.22	8	58161	470	46627423
Eyelid ptosis	13.32	10.22	26	58143	6162	46621731
Brain death	13.30	10.22	17	58152	2806	46625087
Hepatotoxicity	13.23	10.22	64	58105	24945	46602948
Genital ulceration	13.22	10.22	8	58161	480	46627413
Fear-related avoidance of activities	13.17	10.22	5	58164	104	46627789
Cholestasis of pregnancy	13.07	10.22	11	58158	1113	46626780
Vascular resistance systemic decreased	12.99	10.22	5	58164	108	46627785
Tryptase increased	12.98	10.22	6	58163	207	46627686
Application site alopecia	12.92	10.22	3	58166	9	46627884
Weight increased	12.80	10.22	137	58032	164336	46463557
Eosinophilia	12.79	10.22	4	58165	19213	46608680
Surgery	12.69	10.22	70	58099	28715	46599178
Staphylococcal infection	12.58	10.22	82	58087	35689	46592204
Product contamination microbial	12.56	10.22	6	58163	223	46627670
Extradural abscess	12.51	10.22	9	58160	724	46627169
Left ventricle outflow tract obstruction	12.49	10.22	6	58163	226	46627667
Spinal cord oedema	12.31	10.22	5	58164	125	46627768
Foetal heart rate abnormal	12.31	10.22	8	58161	545	46627348
Epidural analgesia	12.20	10.22	4	58165	53	46627840
Loss of personal independence in daily activities	12.11	10.22	34	58135	57149	46570744
Injection site abscess	12.08	10.22	10	58159	989	46626904
Malignant neoplasm progression	12.05	10.22	41	58128	64885	46563008
Infusion site bruising	12.01	10.22	12	58157	1514	46626379
Visual acuity reduced	12.00	10.22	57	58112	22056	46605837
Orthostatic hypotension	11.96	10.22	8	58161	24650	46603243
Impaired healing	11.95	10.22	17	58152	36726	46591167
Syringomyelia	11.93	10.22	4	58165	57	46627836
Anaesthesia	11.93	10.22	4	58165	57	46627836
Neurogenic shock	11.93	10.22	6	58163	250	46627643
Cardiac death	11.92	10.22	8	58161	575	46627318
Polymenorrhagia	11.87	10.22	4	58165	58	46627835
Myocardial infarction	11.85	10.22	72	58097	97456	46530437
Accidental overdose	11.83	10.22	53	58116	20013	46607880
Arthritis fungal	11.71	10.22	3	58166	15	46627878
White blood cell count decreased	11.57	10.22	87	58082	112144	46515749
Nerve block	11.44	10.22	7	58162	429	46627464
Multiple sclerosis relapse	11.37	10.22	22	58147	42103	46585790
Lung disorder	11.35	10.22	23	58146	43281	46584612
Pneumonia mycoplasmal	11.34	10.22	9	58160	839	46627054
Paralysis	11.34	10.22	30	58139	8691	46619202
Neoplasm progression	11.24	10.22	10	58159	26673	46601220
Treatment failure	11.17	10.22	69	58100	93018	46534875
Gastrointestinal haemorrhage	11.12	10.22	54	58115	77319	46550574
Agranulocytosis	11.03	10.22	7	58162	22178	46605715
Peripheral swelling	11.00	10.22	135	58034	157936	46469957
Cauda equina syndrome	10.99	10.22	8	58161	655	46627238
Retinal artery occlusion	10.99	10.22	11	58158	1391	46626502
Suicidal ideation	10.98	10.22	113	58056	56269	46571624
Haemorrhagic vasculitis	10.97	10.22	4	58165	74	46627819
Nasopharyngitis	10.91	10.22	131	58038	153867	46474026
Malaise	10.86	10.22	322	57847	330910	46296983
Device expulsion	10.81	10.22	11	58158	27531	46600362
Implant site swelling	10.79	10.22	7	58162	475	46627418
Retinal cyst	10.77	10.22	4	58165	78	46627815
Withdrawal syndrome	10.77	10.22	48	58121	18086	46609807
Cerebral congestion	10.73	10.22	3	58166	22	46627871
Gastrooesophageal reflux disease	10.62	10.22	52	58117	74292	46553601
Pupillary reflex impaired	10.62	10.22	13	58156	2055	46625838
Toxicologic test abnormal	10.61	10.22	8	58161	691	46627202
Arthropathy	10.57	10.22	62	58107	84638	46543255
Repetitive strain injury	10.54	10.22	5	58164	183	46627710
Pneumocystis jirovecii pneumonia	10.46	10.22	3	58166	15245	46612648
Product prescribing error	10.42	10.22	6	58163	20041	46607852
Stridor	10.42	10.22	16	58153	3131	46624762
Systemic toxicity	10.40	10.22	3	58166	25	46627868
Retrograde amnesia	10.28	10.22	6	58163	337	46627556
Inadequate analgesia	10.27	10.22	15	58154	2809	46625084
Hepatocellular injury	10.27	10.22	13	58156	29509	46598384
Infusion site rash	10.24	10.22	9	58160	966	46626927

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	2019.80	11.05	1816	41644	175367	29733651
Drug abuse	1949.96	11.05	1303	42157	80769	29828249
Completed suicide	1790.92	11.05	1333	42127	98159	29810859
Intentional overdose	483.22	11.05	433	43027	41048	29867970
Overdose	428.59	11.05	568	42892	83769	29825249
Cardio-respiratory arrest	409.95	11.05	459	43001	56847	29852171
Alcohol abuse	393.86	11.05	180	43280	5173	29903845
Alcohol interaction	306.63	11.05	124	43336	2618	29906400
Suicide attempt	288.35	11.05	309	43151	36388	29872630
Intentional product misuse	270.76	11.05	291	43169	34376	29874642
Substance abuse	190.94	11.05	122	43338	6918	29902100
Suspected suicide	173.69	11.05	87	43373	3074	29905944
Alcohol poisoning	173.36	11.05	92	43368	3672	29905346
Cardiac arrest	153.65	11.05	384	43076	92466	29816552
Methaemoglobinaemia	140.61	11.05	70	43390	2440	29906578
Respiratory arrest	140.46	11.05	192	43268	29066	29879952
Drug dependence	126.05	11.05	155	43305	21140	29887878
Respiratory depression	123.76	11.05	115	43345	11388	29897630
Alcohol use	119.36	11.05	72	43388	3683	29905335
Anaesthetic complication	114.90	11.05	47	43413	1022	29907996
Coma	107.84	11.05	203	43257	40246	29868772
Anaphylactic reaction	102.95	11.05	162	43298	27820	29881198
Incorrect route of product administration	86.51	11.05	94	43366	11221	29897797
Diarrhoea	77.45	11.05	239	43221	333864	29575154
Asphyxia	75.94	11.05	63	43397	5362	29903656
Poisoning deliberate	73.31	11.05	64	43396	5840	29903178
Blood alcohol increased	70.64	11.05	32	43428	899	29908119
Fear	69.27	11.05	82	43378	10743	29898275
Hypotension	68.27	11.05	511	42949	200054	29708964
Ventricular tachycardia	67.64	11.05	123	43337	23739	29885279
Intentional product use issue	66.87	11.05	157	43303	36283	29872735
Aggression	65.55	11.05	157	43303	36750	29872268
Toxic anterior segment syndrome	63.95	11.05	35	43425	1486	29907532
Unresponsive to stimuli	63.55	11.05	127	43333	26292	29882726
Injury	62.84	11.05	113	43347	21618	29887400
Tachycardia	61.90	11.05	241	43219	73498	29835520
Anaemia	61.80	11.05	131	43329	207861	29701157
Renal injury	59.34	11.05	79	43381	11650	29897368
Anaphylactic shock	55.63	11.05	84	43376	13909	29895109
Local anaesthetic systemic toxicity	50.73	11.05	16	43444	157	29908861
Anhedonia	49.63	11.05	61	43399	8308	29900710
Dyspnoea	49.43	11.05	283	43177	333012	29576006
Mydriasis	48.65	11.05	52	43408	6091	29902927
Emotional distress	48.18	11.05	84	43376	15681	29893337
Poisoning	47.64	11.05	70	43390	11312	29897706
Death	45.27	11.05	748	42712	356535	29552483
Drug withdrawal syndrome	44.99	11.05	93	43367	19716	29889302
Electrocardiogram QRS complex prolonged	44.53	11.05	42	43418	4235	29904783
Alcohol withdrawal syndrome	43.56	11.05	28	43432	1603	29907415
Decreased appetite	43.17	11.05	96	43364	149814	29759204
General physical health deterioration	42.96	11.05	49	43411	99895	29809123
Disease progression	42.79	11.05	32	43428	79842	29829176
Interstitial lung disease	42.58	11.05	17	43443	60180	29848838
Pneumonia	42.29	11.05	298	43162	334008	29575010
Accidental overdose	41.74	11.05	86	43374	18189	29890829
Ventricular fibrillation	41.59	11.05	77	43383	15061	29893957
Pyrexia	40.49	11.05	256	43204	294233	29614785
Generalised tonic-clonic seizure	40.03	11.05	88	43372	19463	29889555
Fatigue	39.99	11.05	287	43173	320386	29588632
Accidental death	39.66	11.05	29	43431	2050	29906968
Drug screen positive	37.92	11.05	39	43421	4368	29904650
Cardiac failure congestive	37.79	11.05	40	43420	84367	29824651
Medication error	36.99	11.05	89	43371	20883	29888135
Weight decreased	36.95	11.05	105	43355	150816	29758202
Anaesthetic complication neurological	36.93	11.05	15	43445	320	29908698
Myocardial infarction	36.52	11.05	80	43380	125545	29783473
Neutropenia	36.43	11.05	83	43377	128457	29780561
Asthenia	35.99	11.05	182	43278	221108	29687910
Electrocardiogram ST segment elevation	35.88	11.05	38	43422	4404	29904614
Suicidal ideation	35.27	11.05	124	43336	35990	29873028
Therapy interrupted	35.27	11.05	38	43422	4491	29904527
Loss of consciousness	33.25	11.05	213	43247	79162	29829856
Depressed level of consciousness	32.92	11.05	126	43334	38096	29870922
Miosis	32.80	11.05	48	43412	7728	29901290
Metabolic acidosis	32.68	11.05	124	43336	37337	29871681
Ex-drug abuser	32.17	11.05	12	43448	202	29908816
Sinus tachycardia	31.98	11.05	70	43390	15434	29893584
Rheumatoid arthritis	31.92	11.05	10	43450	41187	29867831
Cardiac failure	31.58	11.05	45	43415	83373	29825645
Brain oedema	31.50	11.05	61	43399	12337	29896681
Oculocardiac reflex	31.34	11.05	9	43451	62	29908956
Alcoholism	30.81	11.05	31	43429	3383	29905635
Road traffic accident	30.70	11.05	73	43387	16998	29892020
Platelet count decreased	30.49	11.05	68	43392	106061	29802957
Intentional self-injury	30.11	11.05	63	43397	13469	29895549
Shock	30.10	11.05	87	43373	22772	29886246
Unevaluable event	30.06	11.05	108	43352	31677	29877341
Alcohol intolerance	29.87	11.05	14	43446	426	29908592
Drug abuser	29.25	11.05	34	43426	4367	29904651
White blood cell count decreased	29.17	11.05	48	43412	83899	29825119
Haemoglobin decreased	28.19	11.05	79	43381	114019	29794999
Bradycardia	28.15	11.05	177	43283	65349	29843669
Homicide	28.04	11.05	18	43442	1028	29907990
Dehydration	28.03	11.05	89	43371	123450	29785568
Infusion site pain	27.55	11.05	26	43434	2624	29906394
Psoriasis	26.94	11.05	14	43446	42492	29866526
Agitation	26.38	11.05	151	43309	53922	29855096
Drug intolerance	25.76	11.05	17	43443	45274	29863744
Arthralgia	25.41	11.05	106	43354	135685	29773333
Exposure to toxic agent	24.47	11.05	17	43443	1108	29907910
Pulmonary oedema	24.27	11.05	127	43333	43848	29865170
Product dose omission issue	23.71	11.05	62	43398	91569	29817449
Rash	23.23	11.05	173	43287	191716	29717302
Thrombocytopenia	23.22	11.05	111	43349	136933	29772085
Sopor	23.10	11.05	50	43410	10941	29898077
Anxiety	22.99	11.05	215	43245	89656	29819362
Bezoar	22.64	11.05	15	43445	904	29908114
Acute kidney injury	22.44	11.05	272	43188	273570	29635448
Myalgia	22.11	11.05	49	43411	76618	29832400
Embolia cutis medicamentosa	22.03	11.05	9	43451	195	29908823
Malaise	21.93	11.05	147	43313	166815	29742203
Foetal alcohol syndrome	21.78	11.05	9	43451	201	29908817
Cough	21.73	11.05	101	43359	125541	29783477
Removal of foreign body	21.58	11.05	5	43455	12	29909006
Oedema peripheral	21.46	11.05	80	43380	105752	29803266
Abdominal pain	21.20	11.05	113	43347	135541	29773477
Off label use	21.03	11.05	246	43214	249044	29659974
Malignant neoplasm progression	21.01	11.05	46	43414	72241	29836777
Lagophthalmos	20.70	11.05	7	43453	87	29908931
Coronary artery disease	20.67	11.05	25	43435	49687	29859331
Somnolence	20.66	11.05	223	43237	96540	29812478
Pulmonary embolism	20.11	11.05	53	43407	78082	29830936
Asthma	20.00	11.05	14	43446	36160	29872858
Apnoea	19.98	11.05	34	43426	6224	29902794
Condition aggravated	19.83	11.05	118	43342	137748	29771270
Eosinophilia	19.83	11.05	4	43456	22156	29886862
Vitreous floaters	19.81	11.05	24	43436	3220	29905798
Angina pectoris	19.80	11.05	9	43451	29509	29879509
Cytomegalovirus infection	19.72	11.05	5	43455	23669	29885349
Leukopenia	19.60	11.05	32	43428	56127	29852891
Agranulocytosis	19.55	11.05	4	43456	21938	29887080
Hepatic fibrosis	19.48	11.05	25	43435	3555	29905463
Intracranial hypotension	19.48	11.05	9	43451	265	29908753
Impaired driving ability	19.38	11.05	21	43439	2497	29906521
Blood creatinine increased	19.23	11.05	68	43392	91307	29817711
Pancytopenia	18.77	11.05	62	43398	84990	29824028
Anal sphincter atony	18.49	11.05	6	43454	65	29908953
Product adhesion issue	18.42	11.05	16	43444	1449	29907569
Amnesia	18.39	11.05	77	43383	24244	29884774
Product preparation error	18.23	11.05	17	43443	1689	29907329
Neuropathy peripheral	17.99	11.05	48	43412	70427	29838591
Reperfusion arrhythmia	17.94	11.05	6	43454	72	29908946
Drug level increased	17.89	11.05	63	43397	18291	29890727
Tryptase increased	17.88	11.05	8	43452	218	29908800
International normalised ratio increased	17.81	11.05	26	43434	47713	29861305
Dysarthria	17.48	11.05	89	43371	30401	29878617
Peritonitis	16.90	11.05	5	43455	21370	29887648
Stress	16.84	11.05	66	43394	20169	29888849
Injection site ulcer	16.81	11.05	8	43452	252	29908766
Physical assault	16.79	11.05	14	43446	1199	29907819
Haematochezia	16.71	11.05	15	43445	34207	29874811
Pain in extremity	16.56	11.05	93	43367	110128	29798890
Pulse absent	16.51	11.05	29	43431	5444	29903574
Dextrocardia	16.39	11.05	7	43453	170	29908848
Chronic obstructive pulmonary disease	16.36	11.05	26	43434	46100	29862918
Electrocardiogram T wave amplitude increased	16.34	11.05	5	43455	44	29908974
Retinal vasculitis	16.28	11.05	8	43452	271	29908747
Administration site pain	15.95	11.05	7	43453	182	29908836
Bone marrow failure	15.85	11.05	12	43448	29773	29879245
Drug reaction with eosinophilia and systemic symptoms	15.78	11.05	11	43449	28477	29880541
Acute pulmonary oedema	15.58	11.05	34	43426	7481	29901537
Cardiotoxicity	15.46	11.05	25	43435	4389	29904629
Diabetes mellitus	15.42	11.05	23	43437	41842	29867176
Gastrointestinal disorder	15.41	11.05	11	43449	28126	29880892
Drug resistance	15.39	11.05	5	43455	20128	29888890
Pupil fixed	15.38	11.05	16	43444	1816	29907202
Circulatory collapse	15.28	11.05	64	43396	20150	29888868
Acute myocardial infarction	15.12	11.05	34	43426	52905	29856113
Drug use disorder	15.10	11.05	21	43439	3227	29905791
Toxicologic test abnormal	15.09	11.05	10	43450	603	29908415
Tracheitis	15.03	11.05	10	43450	607	29908411
Respiratory acidosis	14.99	11.05	24	43436	4178	29904840
Infusion site erythema	14.95	11.05	15	43445	1631	29907387
Gun shot wound	14.90	11.05	13	43447	1185	29907833
Deep vein thrombosis	14.85	11.05	42	43418	60459	29848559
Plasma cell myeloma	14.74	11.05	35	43425	53427	29855591
Spinal cord infarction	14.70	11.05	7	43453	221	29908797
Hypoxia	14.57	11.05	119	43341	47735	29861283
Hepatic function abnormal	14.54	11.05	24	43436	41921	29867097
Sinusitis	14.26	11.05	90	43370	33255	29875763
Myoclonus	14.12	11.05	47	43413	13265	29895753
Myokymia	13.93	11.05	5	43455	75	29908943
Neuromuscular blockade	13.89	11.05	6	43454	150	29908868
Corneal oedema	13.88	11.05	13	43447	1299	29907719
Jaundice	13.86	11.05	16	43444	32470	29876548
Melaena	13.81	11.05	16	43444	32421	29876597
Somnambulism	13.79	11.05	20	43440	3194	29905824
Delayed recovery from anaesthesia	13.75	11.05	10	43450	701	29908317
Transient ischaemic attack	13.61	11.05	10	43450	25190	29883828
Prostate cancer	13.61	11.05	9	43451	23948	29885070
Pneumocystis jirovecii pneumonia	13.54	11.05	4	43456	17116	29891902
Blindness	13.54	11.05	44	43416	12265	29896753
Behaviour disorder	13.37	11.05	17	43443	2395	29906623
Wrong product administered	13.33	11.05	24	43436	4594	29904424
Sepsis	13.29	11.05	142	43318	146253	29762765
Bronchospasm	13.27	11.05	39	43421	10299	29898719
Corneal opacity	13.18	11.05	9	43451	570	29908448
Oesophageal obstruction	13.14	11.05	8	43452	416	29908602
Administration related reaction	12.94	11.05	5	43455	93	29908925
Endophthalmitis	12.58	11.05	20	43440	3460	29905558
Dyspnoea exertional	12.54	11.05	20	43440	35410	29873608
Brachial plexus injury	12.17	11.05	5	43455	110	29908908
Alcoholic liver disease	12.14	11.05	9	43451	650	29908368
Ophthalmoplegia	12.06	11.05	12	43448	1292	29907726
Hyperkalaemia	12.04	11.05	52	43408	65958	29843060
Haemodynamic instability	12.02	11.05	32	43428	7983	29901035
Accident	12.02	11.05	20	43440	3593	29905425
Accidental poisoning	11.87	11.05	8	43452	496	29908522
Disease recurrence	11.78	11.05	3	43457	14158	29894860
Inappropriate schedule of product administration	11.77	11.05	25	43435	39703	29869315
Paranoia	11.74	11.05	37	43423	10151	29898867
Chemical poisoning	11.73	11.05	5	43455	121	29908897
Restlessness	11.60	11.05	64	43396	22535	29886483
Haemoptysis	11.52	11.05	17	43443	31061	29877957
Infusion site bruising	11.48	11.05	6	43454	232	29908786
Weight increased	11.36	11.05	63	43397	74850	29834168
Liver disorder	11.27	11.05	16	43444	29706	29879312
Diaphragmatic paralysis	11.21	11.05	8	43452	544	29908474
Red blood cell count decreased	11.19	11.05	13	43447	26308	29882710
Abdominal discomfort	11.15	11.05	35	43425	48756	29860262
Musculoskeletal stiffness	11.12	11.05	22	43438	35859	29873159
Haematuria	11.09	11.05	31	43429	44803	29864215

Pharmacologic Action:

Source	Code	Description
ATC	D08AJ01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quaternary ammonium compounds
ATC	D09AA05	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	D09AA11	DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives
ATC	R02AA16	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
CHEBI has role	CHEBI:27780	detergents
CHEBI has role	CHEBI:33282	antibacterials
CHEBI has role	CHEBI:35195	surface active agent
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D003902	Detergents
MeSH PA	D010592	Pharmaceutic Aids
MeSH PA	D011310	Preservatives, Pharmaceutical
MeSH PA	D013501	Surface-Active Agents
CHEBI has role	CHEBI:51076	antifoulant

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Uveitis	indication	128473001	DOID:13141
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Allergic otitis externa	indication	405821001
Itching of skin	indication	418363000
Itching of ear	indication	699392007
Post-Op Ocular Inflammation	indication
Suppression of the Gag Reflex	indication
Mouth Irritation	indication
Prevent Minor Bacterial Skin Infection	indication
Minor Skin Wound Pain	indication
Bacterial septicemia	contraindication	10001005	DOID:0040085
Hypocupremia	contraindication	19577007
Infection of skin AND/OR subcutaneous tissue	contraindication	19824006
Shock	contraindication	27942005
Methemoglobinemia	contraindication	38959009	DOID:10783
Conduction disorder of the heart	contraindication	44808001
Perforation of tympanic membrane	contraindication	60442001
Diabetes mellitus	contraindication	73211009	DOID:9351
Decreased respiratory function	contraindication	80954004
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Deficiency of cytochrome-b>5< reductase	contraindication	124184009
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Heart block	contraindication	233916004
Disease of liver	contraindication	235856003	DOID:409
Condyloma acuminatum	contraindication	240542006	DOID:11168
Peripheral vascular disease	contraindication	400047006
Blister	contraindication	417237009
Denuded skin	contraindication	418242004
Inflammatory dermatosis	contraindication	703938007

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
7N6JUD5X6Y	UNII
4018249	VUID
N0000178890	NUI
D00857	KEGG_DRUG
8001-54-5	SECONDARY_CAS_RN
4018249	VANDF
4023321	VANDF
C0005025	UMLSCUI
CHEBI:3020	CHEBI
CHEMBL1187417	ChEMBL_ID
CHEMBL502109	ChEMBL_ID
CHEMBL1907001	ChEMBL_ID
DB11105	DRUGBANK_ID
DB13282	DRUGBANK_ID
D001548	MESH_DESCRIPTOR_UI
1168	INN_ID
2330	PUBCHEM_CID
1311593	RXNORM
4255	MMSL
5003	MMSL
003141	NDDF
005466	NDDF
006369	NDDF
373549009	SNOMEDCT_US
64686009	SNOMEDCT_US
735078001	SNOMEDCT_US
90370005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Stay Safe Hand Sanitizer Alcohol Free	HUMAN OTC DRUG LABEL	1	0295-9049	GEL	0.13 mg	TOPICAL	OTC monograph not final	10 sections
Hand wash	HUMAN OTC DRUG LABEL	1	0363-0082	SOAP	1.30 mg	TOPICAL	OTC monograph not final	11 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	1.30 mg	TOPICAL	OTC monograph not final	10 sections
Walgreens Cold Sore Treatment	HUMAN OTC DRUG LABEL	2	0363-0407	CREAM	1.30 mg	TOPICAL	OTC monograph not final	10 sections
Nicefresh scent	HUMAN OTC DRUG LABEL	1	0363-0554	CLOTH	0.12 g	TOPICAL	OTC monograph not final	11 sections
First Aid Antiseptic Wipes	HUMAN OTC DRUG LABEL	1	0363-0589	CLOTH	0.00 mg	TOPICAL	OTC monograph not final	11 sections
4x Medicated Toothache and Gum Cream	HUMAN OTC DRUG LABEL	4	0363-0607	CREAM	0.13 g	ORAL	OTC monograph not final	10 sections
Hand wipes	HUMAN OTC DRUG LABEL	1	0363-0644	CLOTH	1.30 g	TOPICAL	OTC monograph not final	12 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0651	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Hand Wash	HUMAN OTC DRUG LABEL	1	0363-0683	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	11 sections
First Aid AntisepticWell at Walgreens	HUMAN OTC DRUG LABEL	2	0363-3286	SPRAY	0.13 g	TOPICAL	OTC monograph not final	11 sections
4x Medicated Toothache and Gum Gel	HUMAN OTC DRUG LABEL	4	0363-6008	GEL	0.13 g	ORAL	OTC monograph not final	10 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	0363-7110	LIQUID	1.25 g	TOPICAL	OTC monograph not final	11 sections
STUDIO 35 BEAUTYAMBER ANTIBACTERIAL REFILL	HUMAN OTC DRUG LABEL	1	0363-7210	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
WalgreensANTIBACTERIAL HAND REFILL	HUMAN OTC DRUG LABEL	1	0363-7211	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
STUDIO 35AMBER	HUMAN OTC DRUG LABEL	1	0363-7215	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Antiseptic Pain Relieving	HUMAN OTC DRUG LABEL	2	0363-7779	SPRAY	0.10 g	TOPICAL	OTC monograph not final	7 sections
Walgreens	HUMAN OTC DRUG LABEL	2	0363-7950	SPRAY	0.13 g	TOPICAL	OTC monograph not final	12 sections
Walgreens Fresh Antibacterial Foaming Hand	HUMAN OTC DRUG LABEL	1	0363-9000	SOAP	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens Citrus Antibacterial Foaming Hand	HUMAN OTC DRUG LABEL	1	0363-9002	SOAP	1.30 mg	TOPICAL	OTC monograph not final	12 sections
HUMCO Merthiolate	HUMAN OTC DRUG LABEL	1	0395-8010	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	13 sections
Merthiolate	HUMAN OTC DRUG LABEL	1	0395-9122	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
Hand Sanitizer	HUMAN OTC DRUG LABEL	1	0404-4445	LIQUID	7.49 g	TOPICAL	OTC monograph not final	11 sections
BZK Towelette	HUMAN OTC DRUG LABEL	1	0404-5824	SWAB	0.00 mL	TOPICAL	OTC monograph not final	8 sections
BZK	HUMAN OTC DRUG LABEL	1	0404-6735	LIQUID	0.00 g	TOPICAL	OTC monograph not final	11 sections
NORTH Antiseptic First Aid	HUMAN OTC DRUG LABEL	2	0498-0016	SPRAY, METERED	107.10 mg	TOPICAL	OTC monograph not final	10 sections
North Antiseptic	HUMAN OTC DRUG LABEL	1	0498-0401	SPRAY	0.13 g	TOPICAL	OTC monograph not final	14 sections
Antiseptic	HUMAN OTC DRUG LABEL	1	0498-0402	SPRAY	0.13 g	TOPICAL	OTC monograph not final	14 sections
Antiseptic Towelette	HUMAN OTC DRUG LABEL	1	0498-0501	LIQUID	1.30 mg	TOPICAL	OTC monograph not final	12 sections
First Aid Burn	HUMAN OTC DRUG LABEL	2	0498-0903	CREAM	0.13 g	TOPICAL	OTC monograph not final	13 sections