benzalkonium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3017 139-07-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzalkonium chloride
  • benzalkonium
  • benzyldodecyldimethylammonium chloride
  • benzododecinium
A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.
  • Molecular weight: 304.54
  • Formula: C21H38N
  • CLOGP: 3.18
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA:
  • ALOGS: -7.85
  • ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2402.18 10.22 1744 56425 144176 46483717
Toxicity to various agents 1686.93 10.22 1667 56502 210099 46417794
Drug abuse 567.21 10.22 534 57635 62874 46565019
Cardio-respiratory arrest 533.17 10.22 503 57666 59366 46568527
Intentional overdose 504.03 10.22 506 57663 64438 46563455
Overdose 374.23 10.22 543 57626 101436 46526457
Alcohol interaction 280.50 10.22 108 58061 2337 46625556
Cardiac arrest 275.86 10.22 442 57727 89957 46537936
Suicide attempt 275.17 10.22 341 57828 54695 46573198
Methaemoglobinaemia 187.27 10.22 78 58091 2084 46625809
Alcohol poisoning 167.24 10.22 73 58096 2195 46625698
Suspected suicide 157.07 10.22 88 58081 4573 46623320
Local anaesthetic systemic toxicity 151.60 10.22 43 58126 335 46627558
Toxic anterior segment syndrome 135.86 10.22 62 58107 2075 46625818
Alcohol use 134.03 10.22 64 58105 2378 46625515
Respiratory arrest 133.99 10.22 187 57982 33629 46594264
Intentional product misuse 120.38 10.22 213 57956 46915 46580978
Rheumatoid arthritis 116.83 10.22 78 58091 240137 46387756
Alcohol abuse 104.42 10.22 52 58117 2120 46625773
Death 94.12 10.22 727 57442 334821 46293072
Anaesthetic complication 88.83 10.22 44 58125 1773 46626120
Therapy interrupted 83.39 10.22 84 58085 10707 46617186
Incorrect route of product administration 80.96 10.22 101 58068 16282 46611611
Coma 76.25 10.22 201 57968 58148 46569745
Sinusitis 71.72 10.22 336 57833 129432 46498461
Diarrhoea 68.66 10.22 413 57756 559189 46068704
Generalised tonic-clonic seizure 67.20 10.22 121 58048 27001 46600892
Pulseless electrical activity 67.09 10.22 62 58107 7105 46620788
Somnolence 66.80 10.22 377 57792 156144 46471749
Ventricular tachycardia 65.96 10.22 93 58076 16874 46611019
Seizure 62.49 10.22 311 57858 122743 46505150
Mydriasis 61.91 10.22 71 58098 10482 46617411
Anaphylactic shock 58.82 10.22 97 58072 20177 46607716
Anaphylactic reaction 54.78 10.22 168 58001 52944 46574949
Unresponsive to stimuli 53.93 10.22 122 58047 32052 46595841
Drug ineffective 53.12 10.22 565 57604 677273 45950620
Drug intolerance 53.09 10.22 63 58106 146986 46480907
Maternal exposure during delivery 52.90 10.22 24 58145 792 46627101
General physical health deterioration 51.76 10.22 41 58128 115728 46512165
Blood alcohol increased 51.67 10.22 23 58146 725 46627168
Arthralgia 51.22 10.22 257 57912 364346 46263547
Loss of consciousness 47.66 10.22 263 57906 107975 46519918
Hypotension 46.86 10.22 469 57700 232120 46395773
Alopecia 46.41 10.22 82 58087 162332 46465561
Infusion site swelling 45.20 10.22 45 58124 5654 46622239
Alcoholism 44.31 10.22 30 58139 2188 46625705
Infusion site erythema 42.46 10.22 50 58119 7592 46620301
Pemphigus 41.85 10.22 4 58165 45270 46582623
Contraindicated product administered 41.50 10.22 24 58145 79923 46547970
Procedural hypotension 41.33 10.22 23 58146 1179 46626714
Lagophthalmos 41.00 10.22 15 58154 280 46627613
Poisoning deliberate 40.99 10.22 50 58119 7876 46620017
Pulse absent 40.92 10.22 40 58129 4916 46622977
Asthenia 39.91 10.22 226 57943 310849 46317044
Bradycardia 39.81 10.22 176 57993 66122 46561771
Corneal oedema 39.57 10.22 25 58144 1621 46626272
Joint swelling 38.86 10.22 94 58075 165979 46461914
Respiratory depression 38.46 10.22 59 58110 11541 46616352
Body tinea 38.03 10.22 20 58149 915 46626978
Tachycardia 37.96 10.22 233 57936 99389 46528504
Agitation 37.85 10.22 153 58016 55262 46572631
Exposure to toxic agent 37.30 10.22 26 58143 1988 46625905
Infusion site pruritus 37.10 10.22 31 58138 3107 46624786
Mental status changes 36.08 10.22 117 58052 37971 46589922
Ventricular fibrillation 36.07 10.22 57 58112 11439 46616454
Abdominal discomfort 35.81 10.22 85 58084 151080 46476813
Victim of sexual abuse 35.15 10.22 16 58153 532 46627361
Substance abuse 35.09 10.22 34 58135 4133 46623760
Retinal vasculitis 35.02 10.22 17 58152 655 46627238
Administration site pain 34.90 10.22 17 58152 660 46627233
Anaesthetic complication neurological 34.74 10.22 12 58157 188 46627705
Bursitis infective 33.73 10.22 20 58149 1157 46626736
Fear 33.67 10.22 67 58102 16105 46611788
Postmortem blood drug level abnormal 32.39 10.22 13 58156 315 46627578
Synovitis 32.18 10.22 18 58151 61057 46566836
Systemic lupus erythematosus 31.84 10.22 21 58148 65159 46562734
Parophthalmia 31.72 10.22 12 58157 247 46627646
Corneal epithelium defect 31.61 10.22 13 58156 336 46627557
Fear of eating 31.57 10.22 13 58156 337 46627556
Aggression 31.39 10.22 80 58089 22664 46605229
Anterior chamber cell 31.34 10.22 15 58154 560 46627333
Sinus tachycardia 30.76 10.22 77 58092 21572 46606321
Stress cardiomyopathy 30.75 10.22 43 58126 7741 46620152
Infusion site pain 30.18 10.22 49 58120 10058 46617835
Pneumocephalus 29.86 10.22 10 58159 142 46627751
Electrocardiogram ST segment elevation 28.98 10.22 29 58140 3666 46624227
Cough 28.57 10.22 169 58000 230080 46397813
Infusion site extravasation 28.56 10.22 34 58135 5222 46622671
Renal injury 28.14 10.22 46 58123 9495 46618398
Ophthalmoplegia 27.89 10.22 16 58153 870 46627023
Platelet aggregation inhibition 27.74 10.22 9 58160 115 46627778
Cardiac failure congestive 27.40 10.22 45 58124 91705 46536188
Type I hypersensitivity 27.37 10.22 23 58146 2323 46625570
Gastrointestinal toxicity 26.87 10.22 30 58139 4301 46623592
Acute kidney injury 26.74 10.22 178 57991 235677 46392216
Glossodynia 26.54 10.22 11 58158 44362 46583531
Administration site swelling 26.28 10.22 17 58152 1148 46626745
Pancytopenia 26.08 10.22 41 58128 85017 46542876
Arthritis 25.93 10.22 35 58134 77281 46550612
Kounis syndrome 25.80 10.22 17 58152 1185 46626708
Sensory loss 25.60 10.22 37 58132 6865 46621028
Neutropenia 24.89 10.22 93 58076 143111 46484782
Spinal epidural haemorrhage 24.67 10.22 8 58161 102 46627791
Depressed level of consciousness 24.66 10.22 121 58048 47448 46580445
Anaemia 24.25 10.22 203 57966 255576 46372317
Anhedonia 24.19 10.22 45 58124 10290 46617603
Peripheral nerve injury 24.16 10.22 11 58158 366 46627527
Neurotoxicity 24.09 10.22 53 58116 13664 46614229
Cyanosis 23.96 10.22 58 58111 15913 46611980
Apnoea 23.87 10.22 37 58132 7302 46620591
Hepatic enzyme increased 23.61 10.22 41 58128 81746 46546147
Meningitis chemical 23.24 10.22 8 58161 124 46627769
Extradural haematoma 23.20 10.22 17 58152 1406 46626487
Decreased appetite 23.13 10.22 144 58025 193692 46434201
Septic arthritis staphylococcal 23.10 10.22 11 58158 406 46627487
Electrocardiogram QRS complex prolonged 22.87 10.22 31 58138 5418 46622475
Infection susceptibility increased 22.66 10.22 20 58149 2159 46625734
Miosis 22.27 10.22 34 58135 6623 46621270
Unevaluable event 22.21 10.22 115 58054 46060 46581833
Psoriasis 22.15 10.22 40 58129 78564 46549329
Electrocardiogram QT prolonged 22.09 10.22 124 58045 51201 46576692
Punctate keratitis 22.00 10.22 12 58157 591 46627302
Leukopenia 21.86 10.22 32 58137 68311 46559582
Spinal anaesthesia 21.84 10.22 6 58163 41 46627852
Atonic urinary bladder 21.75 10.22 7 58162 87 46627806
Pulmonary toxicity 21.71 10.22 28 58141 4665 46623228
Somnambulism 21.67 10.22 29 58140 5008 46622885
C-reactive protein increased 21.23 10.22 25 58144 58565 46569328
Intentional product use issue 21.08 10.22 125 58044 52655 46575238
Weight decreased 21.05 10.22 165 58004 210684 46417209
Glossoptosis 20.80 10.22 6 58163 50 46627843
Injury 20.73 10.22 109 58060 43918 46583975
Therapeutic product effect decreased 20.72 10.22 45 58124 82556 46545337
Product adhesion issue 20.51 10.22 28 58141 4927 46622966
Upper airway obstruction 20.41 10.22 11 58158 529 46627364
Nystagmus 20.34 10.22 30 58139 5669 46622224
Disease progression 20.31 10.22 53 58116 91247 46536646
Thrombocytopenia 20.22 10.22 85 58084 126496 46501397
Incorrect drug administration rate 20.14 10.22 18 58151 1975 46625918
Inhibitory drug interaction 20.13 10.22 18 58151 1977 46625916
Dyspnoea 19.90 10.22 490 57679 515058 46112835
Fall 19.72 10.22 290 57879 328807 46299086
Drug level increased 19.63 10.22 59 58110 18382 46609511
Homicide 19.46 10.22 10 58159 436 46627457
Accidental death 19.40 10.22 17 58152 1818 46626075
Therapy cessation 19.36 10.22 75 58094 26554 46601339
Off label use 19.35 10.22 345 57824 379496 46248397
Spinal epidural haematoma 19.02 10.22 12 58157 776 46627117
Abdominal pain upper 18.89 10.22 105 58064 145200 46482693
Infusion site nodule 18.80 10.22 13 58156 981 46626912
Mobility decreased 18.77 10.22 29 58140 60565 46567328
Drug dependence 18.72 10.22 61 58108 19840 46608053
Chemical submission 18.22 10.22 8 58161 244 46627649
Drug withdrawal syndrome 18.21 10.22 75 58094 27309 46600584
Drug reaction with eosinophilia and systemic symptoms 18.20 10.22 7 58162 29541 46598352
Emotional distress 18.03 10.22 81 58088 30626 46597267
Shock 17.95 10.22 64 58105 21781 46606112
Body dysmorphic disorder 17.74 10.22 7 58162 162 46627731
Drug interaction 17.64 10.22 353 57816 202741 46425152
Abortion spontaneous 17.63 10.22 17 58152 43629 46584264
Neuromuscular block prolonged 17.56 10.22 10 58159 536 46627357
Interstitial lung disease 17.51 10.22 25 58144 53924 46573969
Protein C increased 17.50 10.22 7 58162 168 46627725
Removal of foreign body 17.23 10.22 4 58165 12 46627881
Hypocalcaemia 17.08 10.22 6 58163 26779 46601114
Drug use disorder 17.06 10.22 19 58150 2716 46625177
Poisoning 17.05 10.22 47 58122 13947 46613946
Hyponatraemia 16.83 10.22 67 58102 101265 46526628
Product dose omission issue 16.75 10.22 132 58037 168388 46459505
Pulmonary embolism 16.68 10.22 74 58095 108511 46519382
Fatigue 16.43 10.22 607 57562 608090 46019803
Ventricular extrasystoles 16.41 10.22 40 58129 11023 46616870
Peritonitis 16.36 10.22 3 58166 20711 46607182
Amnesia 16.24 10.22 98 58071 41533 46586360
Administration site extravasation 16.23 10.22 10 58159 620 46627273
Impaired quality of life 16.03 10.22 20 58149 3222 46624671
Myocarditis 16.03 10.22 32 58137 7707 46620186
Respiratory acidosis 15.96 10.22 28 58141 6120 46621773
Genital rash 15.93 10.22 9 58160 475 46627418
Haemoglobin decreased 15.79 10.22 95 58074 128854 46499039
Substance dependence 15.78 10.22 7 58162 219 46627674
Trigeminal palsy 15.61 10.22 4 58165 20 46627873
Incision site rash 15.61 10.22 4 58165 20 46627873
Areflexia 15.52 10.22 19 58150 3004 46624889
Delirium 15.40 10.22 89 58080 37139 46590754
Anal sphincter atony 15.37 10.22 7 58162 233 46627660
Alcoholic 15.33 10.22 5 58164 65 46627828
Status epilepticus 15.14 10.22 45 58124 13934 46613959
Infusion site haemorrhage 15.13 10.22 16 58153 2158 46625735
Drug hypersensitivity 14.88 10.22 214 57955 243611 46384282
Orbital infection 14.86 10.22 4 58165 25 46627868
Anaphylactoid reaction 14.86 10.22 20 58149 3471 46624422
Hypoxia 14.82 10.22 113 58056 51725 46576168
Rash 14.79 10.22 335 57834 356177 46271716
Wound 14.73 10.22 19 58150 42783 46585110
Infusion site urticaria 14.70 10.22 10 58159 735 46627158
Induced abortion failed 14.58 10.22 7 58162 263 46627630
Gastroenteritis 14.49 10.22 6 58163 24213 46603680
Intentional self-injury 14.38 10.22 64 58105 24102 46603791
Conjunctival oedema 14.35 10.22 9 58160 576 46627317
Administration site erythema 14.34 10.22 9 58160 577 46627316
Condition aggravated 14.29 10.22 217 57952 244835 46383058
Femur fracture 14.27 10.22 15 58154 36982 46590911
Propionibacterium infection 14.23 10.22 4 58165 30 46627863
Dissociative amnesia 14.23 10.22 4 58165 30 46627863
Anorgasmia 14.17 10.22 9 58160 589 46627304
Septic shock 14.14 10.22 32 58137 57861 46570032
Liver injury 14.12 10.22 48 58121 15953 46611940
Cholestasis 14.06 10.22 8 58161 26885 46601008
Eye infarction 14.01 10.22 4 58165 32 46627861
Airway peak pressure increased 13.97 10.22 7 58162 289 46627604
Pulmonary oedema 13.83 10.22 110 58059 50995 46576898
Osteoarthritis 13.79 10.22 36 58133 61989 46565904
Anaphylactoid shock 13.78 10.22 7 58162 298 46627595
Psoriatic arthropathy 13.75 10.22 15 58154 36364 46591529
Asthma 13.69 10.22 63 58106 91479 46536414
Harlequin syndrome 13.49 10.22 4 58165 37 46627856
Cardiogenic shock 13.46 10.22 48 58121 16336 46611557
Arthritis bacterial 13.46 10.22 25 58144 5711 46622182
Congenital umbilical hernia 13.38 10.22 8 58161 470 46627423
Eyelid ptosis 13.32 10.22 26 58143 6162 46621731
Brain death 13.30 10.22 17 58152 2806 46625087
Hepatotoxicity 13.23 10.22 64 58105 24945 46602948
Genital ulceration 13.22 10.22 8 58161 480 46627413
Fear-related avoidance of activities 13.17 10.22 5 58164 104 46627789
Cholestasis of pregnancy 13.07 10.22 11 58158 1113 46626780
Vascular resistance systemic decreased 12.99 10.22 5 58164 108 46627785
Tryptase increased 12.98 10.22 6 58163 207 46627686
Application site alopecia 12.92 10.22 3 58166 9 46627884
Weight increased 12.80 10.22 137 58032 164336 46463557
Eosinophilia 12.79 10.22 4 58165 19213 46608680
Surgery 12.69 10.22 70 58099 28715 46599178
Staphylococcal infection 12.58 10.22 82 58087 35689 46592204
Product contamination microbial 12.56 10.22 6 58163 223 46627670
Extradural abscess 12.51 10.22 9 58160 724 46627169
Left ventricle outflow tract obstruction 12.49 10.22 6 58163 226 46627667
Spinal cord oedema 12.31 10.22 5 58164 125 46627768
Foetal heart rate abnormal 12.31 10.22 8 58161 545 46627348
Epidural analgesia 12.20 10.22 4 58165 53 46627840
Loss of personal independence in daily activities 12.11 10.22 34 58135 57149 46570744
Injection site abscess 12.08 10.22 10 58159 989 46626904
Malignant neoplasm progression 12.05 10.22 41 58128 64885 46563008
Infusion site bruising 12.01 10.22 12 58157 1514 46626379
Visual acuity reduced 12.00 10.22 57 58112 22056 46605837
Orthostatic hypotension 11.96 10.22 8 58161 24650 46603243
Impaired healing 11.95 10.22 17 58152 36726 46591167
Syringomyelia 11.93 10.22 4 58165 57 46627836
Anaesthesia 11.93 10.22 4 58165 57 46627836
Neurogenic shock 11.93 10.22 6 58163 250 46627643
Cardiac death 11.92 10.22 8 58161 575 46627318
Polymenorrhagia 11.87 10.22 4 58165 58 46627835
Myocardial infarction 11.85 10.22 72 58097 97456 46530437
Accidental overdose 11.83 10.22 53 58116 20013 46607880
Arthritis fungal 11.71 10.22 3 58166 15 46627878
White blood cell count decreased 11.57 10.22 87 58082 112144 46515749
Nerve block 11.44 10.22 7 58162 429 46627464
Multiple sclerosis relapse 11.37 10.22 22 58147 42103 46585790
Lung disorder 11.35 10.22 23 58146 43281 46584612
Pneumonia mycoplasmal 11.34 10.22 9 58160 839 46627054
Paralysis 11.34 10.22 30 58139 8691 46619202
Neoplasm progression 11.24 10.22 10 58159 26673 46601220
Treatment failure 11.17 10.22 69 58100 93018 46534875
Gastrointestinal haemorrhage 11.12 10.22 54 58115 77319 46550574
Agranulocytosis 11.03 10.22 7 58162 22178 46605715
Peripheral swelling 11.00 10.22 135 58034 157936 46469957
Cauda equina syndrome 10.99 10.22 8 58161 655 46627238
Retinal artery occlusion 10.99 10.22 11 58158 1391 46626502
Suicidal ideation 10.98 10.22 113 58056 56269 46571624
Haemorrhagic vasculitis 10.97 10.22 4 58165 74 46627819
Nasopharyngitis 10.91 10.22 131 58038 153867 46474026
Malaise 10.86 10.22 322 57847 330910 46296983
Device expulsion 10.81 10.22 11 58158 27531 46600362
Implant site swelling 10.79 10.22 7 58162 475 46627418
Retinal cyst 10.77 10.22 4 58165 78 46627815
Withdrawal syndrome 10.77 10.22 48 58121 18086 46609807
Cerebral congestion 10.73 10.22 3 58166 22 46627871
Gastrooesophageal reflux disease 10.62 10.22 52 58117 74292 46553601
Pupillary reflex impaired 10.62 10.22 13 58156 2055 46625838
Toxicologic test abnormal 10.61 10.22 8 58161 691 46627202
Arthropathy 10.57 10.22 62 58107 84638 46543255
Repetitive strain injury 10.54 10.22 5 58164 183 46627710
Pneumocystis jirovecii pneumonia 10.46 10.22 3 58166 15245 46612648
Product prescribing error 10.42 10.22 6 58163 20041 46607852
Stridor 10.42 10.22 16 58153 3131 46624762
Systemic toxicity 10.40 10.22 3 58166 25 46627868
Retrograde amnesia 10.28 10.22 6 58163 337 46627556
Inadequate analgesia 10.27 10.22 15 58154 2809 46625084
Hepatocellular injury 10.27 10.22 13 58156 29509 46598384
Infusion site rash 10.24 10.22 9 58160 966 46626927

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 2019.80 11.05 1816 41644 175367 29733651
Drug abuse 1949.96 11.05 1303 42157 80769 29828249
Completed suicide 1790.92 11.05 1333 42127 98159 29810859
Intentional overdose 483.22 11.05 433 43027 41048 29867970
Overdose 428.59 11.05 568 42892 83769 29825249
Cardio-respiratory arrest 409.95 11.05 459 43001 56847 29852171
Alcohol abuse 393.86 11.05 180 43280 5173 29903845
Alcohol interaction 306.63 11.05 124 43336 2618 29906400
Suicide attempt 288.35 11.05 309 43151 36388 29872630
Intentional product misuse 270.76 11.05 291 43169 34376 29874642
Substance abuse 190.94 11.05 122 43338 6918 29902100
Suspected suicide 173.69 11.05 87 43373 3074 29905944
Alcohol poisoning 173.36 11.05 92 43368 3672 29905346
Cardiac arrest 153.65 11.05 384 43076 92466 29816552
Methaemoglobinaemia 140.61 11.05 70 43390 2440 29906578
Respiratory arrest 140.46 11.05 192 43268 29066 29879952
Drug dependence 126.05 11.05 155 43305 21140 29887878
Respiratory depression 123.76 11.05 115 43345 11388 29897630
Alcohol use 119.36 11.05 72 43388 3683 29905335
Anaesthetic complication 114.90 11.05 47 43413 1022 29907996
Coma 107.84 11.05 203 43257 40246 29868772
Anaphylactic reaction 102.95 11.05 162 43298 27820 29881198
Incorrect route of product administration 86.51 11.05 94 43366 11221 29897797
Diarrhoea 77.45 11.05 239 43221 333864 29575154
Asphyxia 75.94 11.05 63 43397 5362 29903656
Poisoning deliberate 73.31 11.05 64 43396 5840 29903178
Blood alcohol increased 70.64 11.05 32 43428 899 29908119
Fear 69.27 11.05 82 43378 10743 29898275
Hypotension 68.27 11.05 511 42949 200054 29708964
Ventricular tachycardia 67.64 11.05 123 43337 23739 29885279
Intentional product use issue 66.87 11.05 157 43303 36283 29872735
Aggression 65.55 11.05 157 43303 36750 29872268
Toxic anterior segment syndrome 63.95 11.05 35 43425 1486 29907532
Unresponsive to stimuli 63.55 11.05 127 43333 26292 29882726
Injury 62.84 11.05 113 43347 21618 29887400
Tachycardia 61.90 11.05 241 43219 73498 29835520
Anaemia 61.80 11.05 131 43329 207861 29701157
Renal injury 59.34 11.05 79 43381 11650 29897368
Anaphylactic shock 55.63 11.05 84 43376 13909 29895109
Local anaesthetic systemic toxicity 50.73 11.05 16 43444 157 29908861
Anhedonia 49.63 11.05 61 43399 8308 29900710
Dyspnoea 49.43 11.05 283 43177 333012 29576006
Mydriasis 48.65 11.05 52 43408 6091 29902927
Emotional distress 48.18 11.05 84 43376 15681 29893337
Poisoning 47.64 11.05 70 43390 11312 29897706
Death 45.27 11.05 748 42712 356535 29552483
Drug withdrawal syndrome 44.99 11.05 93 43367 19716 29889302
Electrocardiogram QRS complex prolonged 44.53 11.05 42 43418 4235 29904783
Alcohol withdrawal syndrome 43.56 11.05 28 43432 1603 29907415
Decreased appetite 43.17 11.05 96 43364 149814 29759204
General physical health deterioration 42.96 11.05 49 43411 99895 29809123
Disease progression 42.79 11.05 32 43428 79842 29829176
Interstitial lung disease 42.58 11.05 17 43443 60180 29848838
Pneumonia 42.29 11.05 298 43162 334008 29575010
Accidental overdose 41.74 11.05 86 43374 18189 29890829
Ventricular fibrillation 41.59 11.05 77 43383 15061 29893957
Pyrexia 40.49 11.05 256 43204 294233 29614785
Generalised tonic-clonic seizure 40.03 11.05 88 43372 19463 29889555
Fatigue 39.99 11.05 287 43173 320386 29588632
Accidental death 39.66 11.05 29 43431 2050 29906968
Drug screen positive 37.92 11.05 39 43421 4368 29904650
Cardiac failure congestive 37.79 11.05 40 43420 84367 29824651
Medication error 36.99 11.05 89 43371 20883 29888135
Weight decreased 36.95 11.05 105 43355 150816 29758202
Anaesthetic complication neurological 36.93 11.05 15 43445 320 29908698
Myocardial infarction 36.52 11.05 80 43380 125545 29783473
Neutropenia 36.43 11.05 83 43377 128457 29780561
Asthenia 35.99 11.05 182 43278 221108 29687910
Electrocardiogram ST segment elevation 35.88 11.05 38 43422 4404 29904614
Suicidal ideation 35.27 11.05 124 43336 35990 29873028
Therapy interrupted 35.27 11.05 38 43422 4491 29904527
Loss of consciousness 33.25 11.05 213 43247 79162 29829856
Depressed level of consciousness 32.92 11.05 126 43334 38096 29870922
Miosis 32.80 11.05 48 43412 7728 29901290
Metabolic acidosis 32.68 11.05 124 43336 37337 29871681
Ex-drug abuser 32.17 11.05 12 43448 202 29908816
Sinus tachycardia 31.98 11.05 70 43390 15434 29893584
Rheumatoid arthritis 31.92 11.05 10 43450 41187 29867831
Cardiac failure 31.58 11.05 45 43415 83373 29825645
Brain oedema 31.50 11.05 61 43399 12337 29896681
Oculocardiac reflex 31.34 11.05 9 43451 62 29908956
Alcoholism 30.81 11.05 31 43429 3383 29905635
Road traffic accident 30.70 11.05 73 43387 16998 29892020
Platelet count decreased 30.49 11.05 68 43392 106061 29802957
Intentional self-injury 30.11 11.05 63 43397 13469 29895549
Shock 30.10 11.05 87 43373 22772 29886246
Unevaluable event 30.06 11.05 108 43352 31677 29877341
Alcohol intolerance 29.87 11.05 14 43446 426 29908592
Drug abuser 29.25 11.05 34 43426 4367 29904651
White blood cell count decreased 29.17 11.05 48 43412 83899 29825119
Haemoglobin decreased 28.19 11.05 79 43381 114019 29794999
Bradycardia 28.15 11.05 177 43283 65349 29843669
Homicide 28.04 11.05 18 43442 1028 29907990
Dehydration 28.03 11.05 89 43371 123450 29785568
Infusion site pain 27.55 11.05 26 43434 2624 29906394
Psoriasis 26.94 11.05 14 43446 42492 29866526
Agitation 26.38 11.05 151 43309 53922 29855096
Drug intolerance 25.76 11.05 17 43443 45274 29863744
Arthralgia 25.41 11.05 106 43354 135685 29773333
Exposure to toxic agent 24.47 11.05 17 43443 1108 29907910
Pulmonary oedema 24.27 11.05 127 43333 43848 29865170
Product dose omission issue 23.71 11.05 62 43398 91569 29817449
Rash 23.23 11.05 173 43287 191716 29717302
Thrombocytopenia 23.22 11.05 111 43349 136933 29772085
Sopor 23.10 11.05 50 43410 10941 29898077
Anxiety 22.99 11.05 215 43245 89656 29819362
Bezoar 22.64 11.05 15 43445 904 29908114
Acute kidney injury 22.44 11.05 272 43188 273570 29635448
Myalgia 22.11 11.05 49 43411 76618 29832400
Embolia cutis medicamentosa 22.03 11.05 9 43451 195 29908823
Malaise 21.93 11.05 147 43313 166815 29742203
Foetal alcohol syndrome 21.78 11.05 9 43451 201 29908817
Cough 21.73 11.05 101 43359 125541 29783477
Removal of foreign body 21.58 11.05 5 43455 12 29909006
Oedema peripheral 21.46 11.05 80 43380 105752 29803266
Abdominal pain 21.20 11.05 113 43347 135541 29773477
Off label use 21.03 11.05 246 43214 249044 29659974
Malignant neoplasm progression 21.01 11.05 46 43414 72241 29836777
Lagophthalmos 20.70 11.05 7 43453 87 29908931
Coronary artery disease 20.67 11.05 25 43435 49687 29859331
Somnolence 20.66 11.05 223 43237 96540 29812478
Pulmonary embolism 20.11 11.05 53 43407 78082 29830936
Asthma 20.00 11.05 14 43446 36160 29872858
Apnoea 19.98 11.05 34 43426 6224 29902794
Condition aggravated 19.83 11.05 118 43342 137748 29771270
Eosinophilia 19.83 11.05 4 43456 22156 29886862
Vitreous floaters 19.81 11.05 24 43436 3220 29905798
Angina pectoris 19.80 11.05 9 43451 29509 29879509
Cytomegalovirus infection 19.72 11.05 5 43455 23669 29885349
Leukopenia 19.60 11.05 32 43428 56127 29852891
Agranulocytosis 19.55 11.05 4 43456 21938 29887080
Hepatic fibrosis 19.48 11.05 25 43435 3555 29905463
Intracranial hypotension 19.48 11.05 9 43451 265 29908753
Impaired driving ability 19.38 11.05 21 43439 2497 29906521
Blood creatinine increased 19.23 11.05 68 43392 91307 29817711
Pancytopenia 18.77 11.05 62 43398 84990 29824028
Anal sphincter atony 18.49 11.05 6 43454 65 29908953
Product adhesion issue 18.42 11.05 16 43444 1449 29907569
Amnesia 18.39 11.05 77 43383 24244 29884774
Product preparation error 18.23 11.05 17 43443 1689 29907329
Neuropathy peripheral 17.99 11.05 48 43412 70427 29838591
Reperfusion arrhythmia 17.94 11.05 6 43454 72 29908946
Drug level increased 17.89 11.05 63 43397 18291 29890727
Tryptase increased 17.88 11.05 8 43452 218 29908800
International normalised ratio increased 17.81 11.05 26 43434 47713 29861305
Dysarthria 17.48 11.05 89 43371 30401 29878617
Peritonitis 16.90 11.05 5 43455 21370 29887648
Stress 16.84 11.05 66 43394 20169 29888849
Injection site ulcer 16.81 11.05 8 43452 252 29908766
Physical assault 16.79 11.05 14 43446 1199 29907819
Haematochezia 16.71 11.05 15 43445 34207 29874811
Pain in extremity 16.56 11.05 93 43367 110128 29798890
Pulse absent 16.51 11.05 29 43431 5444 29903574
Dextrocardia 16.39 11.05 7 43453 170 29908848
Chronic obstructive pulmonary disease 16.36 11.05 26 43434 46100 29862918
Electrocardiogram T wave amplitude increased 16.34 11.05 5 43455 44 29908974
Retinal vasculitis 16.28 11.05 8 43452 271 29908747
Administration site pain 15.95 11.05 7 43453 182 29908836
Bone marrow failure 15.85 11.05 12 43448 29773 29879245
Drug reaction with eosinophilia and systemic symptoms 15.78 11.05 11 43449 28477 29880541
Acute pulmonary oedema 15.58 11.05 34 43426 7481 29901537
Cardiotoxicity 15.46 11.05 25 43435 4389 29904629
Diabetes mellitus 15.42 11.05 23 43437 41842 29867176
Gastrointestinal disorder 15.41 11.05 11 43449 28126 29880892
Drug resistance 15.39 11.05 5 43455 20128 29888890
Pupil fixed 15.38 11.05 16 43444 1816 29907202
Circulatory collapse 15.28 11.05 64 43396 20150 29888868
Acute myocardial infarction 15.12 11.05 34 43426 52905 29856113
Drug use disorder 15.10 11.05 21 43439 3227 29905791
Toxicologic test abnormal 15.09 11.05 10 43450 603 29908415
Tracheitis 15.03 11.05 10 43450 607 29908411
Respiratory acidosis 14.99 11.05 24 43436 4178 29904840
Infusion site erythema 14.95 11.05 15 43445 1631 29907387
Gun shot wound 14.90 11.05 13 43447 1185 29907833
Deep vein thrombosis 14.85 11.05 42 43418 60459 29848559
Plasma cell myeloma 14.74 11.05 35 43425 53427 29855591
Spinal cord infarction 14.70 11.05 7 43453 221 29908797
Hypoxia 14.57 11.05 119 43341 47735 29861283
Hepatic function abnormal 14.54 11.05 24 43436 41921 29867097
Sinusitis 14.26 11.05 90 43370 33255 29875763
Myoclonus 14.12 11.05 47 43413 13265 29895753
Myokymia 13.93 11.05 5 43455 75 29908943
Neuromuscular blockade 13.89 11.05 6 43454 150 29908868
Corneal oedema 13.88 11.05 13 43447 1299 29907719
Jaundice 13.86 11.05 16 43444 32470 29876548
Melaena 13.81 11.05 16 43444 32421 29876597
Somnambulism 13.79 11.05 20 43440 3194 29905824
Delayed recovery from anaesthesia 13.75 11.05 10 43450 701 29908317
Transient ischaemic attack 13.61 11.05 10 43450 25190 29883828
Prostate cancer 13.61 11.05 9 43451 23948 29885070
Pneumocystis jirovecii pneumonia 13.54 11.05 4 43456 17116 29891902
Blindness 13.54 11.05 44 43416 12265 29896753
Behaviour disorder 13.37 11.05 17 43443 2395 29906623
Wrong product administered 13.33 11.05 24 43436 4594 29904424
Sepsis 13.29 11.05 142 43318 146253 29762765
Bronchospasm 13.27 11.05 39 43421 10299 29898719
Corneal opacity 13.18 11.05 9 43451 570 29908448
Oesophageal obstruction 13.14 11.05 8 43452 416 29908602
Administration related reaction 12.94 11.05 5 43455 93 29908925
Endophthalmitis 12.58 11.05 20 43440 3460 29905558
Dyspnoea exertional 12.54 11.05 20 43440 35410 29873608
Brachial plexus injury 12.17 11.05 5 43455 110 29908908
Alcoholic liver disease 12.14 11.05 9 43451 650 29908368
Ophthalmoplegia 12.06 11.05 12 43448 1292 29907726
Hyperkalaemia 12.04 11.05 52 43408 65958 29843060
Haemodynamic instability 12.02 11.05 32 43428 7983 29901035
Accident 12.02 11.05 20 43440 3593 29905425
Accidental poisoning 11.87 11.05 8 43452 496 29908522
Disease recurrence 11.78 11.05 3 43457 14158 29894860
Inappropriate schedule of product administration 11.77 11.05 25 43435 39703 29869315
Paranoia 11.74 11.05 37 43423 10151 29898867
Chemical poisoning 11.73 11.05 5 43455 121 29908897
Restlessness 11.60 11.05 64 43396 22535 29886483
Haemoptysis 11.52 11.05 17 43443 31061 29877957
Infusion site bruising 11.48 11.05 6 43454 232 29908786
Weight increased 11.36 11.05 63 43397 74850 29834168
Liver disorder 11.27 11.05 16 43444 29706 29879312
Diaphragmatic paralysis 11.21 11.05 8 43452 544 29908474
Red blood cell count decreased 11.19 11.05 13 43447 26308 29882710
Abdominal discomfort 11.15 11.05 35 43425 48756 29860262
Musculoskeletal stiffness 11.12 11.05 22 43438 35859 29873159
Haematuria 11.09 11.05 31 43429 44803 29864215

Pharmacologic Action:

SourceCodeDescription
ATC D08AJ01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quaternary ammonium compounds
ATC D09AA05 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC D09AA11 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC R02AA16 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
CHEBI has role CHEBI:27780 detergents
CHEBI has role CHEBI:33282 antibacterials
CHEBI has role CHEBI:35195 surface active agent
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:48219 disinfectants
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D003902 Detergents
MeSH PA D010592 Pharmaceutic Aids
MeSH PA D011310 Preservatives, Pharmaceutical
MeSH PA D013501 Surface-Active Agents
CHEBI has role CHEBI:51076 antifoulant

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Uveitis indication 128473001 DOID:13141
Skin irritation indication 367466007
Local anesthesia indication 386761002
Allergic otitis externa indication 405821001
Itching of skin indication 418363000
Itching of ear indication 699392007
Post-Op Ocular Inflammation indication
Suppression of the Gag Reflex indication
Mouth Irritation indication
Prevent Minor Bacterial Skin Infection indication
Minor Skin Wound Pain indication
Bacterial septicemia contraindication 10001005 DOID:0040085
Hypocupremia contraindication 19577007
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Shock contraindication 27942005
Methemoglobinemia contraindication 38959009 DOID:10783
Conduction disorder of the heart contraindication 44808001
Perforation of tympanic membrane contraindication 60442001
Diabetes mellitus contraindication 73211009 DOID:9351
Decreased respiratory function contraindication 80954004
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Peripheral vascular disease contraindication 400047006
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
7N6JUD5X6Y UNII
4018249 VUID
N0000178890 NUI
D00857 KEGG_DRUG
8001-54-5 SECONDARY_CAS_RN
4018249 VANDF
4023321 VANDF
C0005025 UMLSCUI
CHEBI:3020 CHEBI
CHEMBL1187417 ChEMBL_ID
CHEMBL502109 ChEMBL_ID
CHEMBL1907001 ChEMBL_ID
DB11105 DRUGBANK_ID
DB13282 DRUGBANK_ID
D001548 MESH_DESCRIPTOR_UI
1168 INN_ID
2330 PUBCHEM_CID
1311593 RXNORM
4255 MMSL
5003 MMSL
003141 NDDF
005466 NDDF
006369 NDDF
373549009 SNOMEDCT_US
64686009 SNOMEDCT_US
735078001 SNOMEDCT_US
90370005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Stay Safe Hand Sanitizer Alcohol Free HUMAN OTC DRUG LABEL 1 0295-9049 GEL 0.13 mg TOPICAL OTC monograph not final 10 sections
Hand wash HUMAN OTC DRUG LABEL 1 0363-0082 SOAP 1.30 mg TOPICAL OTC monograph not final 11 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 1.30 mg TOPICAL OTC monograph not final 10 sections
Walgreens Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0363-0407 CREAM 1.30 mg TOPICAL OTC monograph not final 10 sections
Nicefresh scent HUMAN OTC DRUG LABEL 1 0363-0554 CLOTH 0.12 g TOPICAL OTC monograph not final 11 sections
First Aid Antiseptic Wipes HUMAN OTC DRUG LABEL 1 0363-0589 CLOTH 0.00 mg TOPICAL OTC monograph not final 11 sections
4x Medicated Toothache and Gum Cream HUMAN OTC DRUG LABEL 4 0363-0607 CREAM 0.13 g ORAL OTC monograph not final 10 sections
Hand wipes HUMAN OTC DRUG LABEL 1 0363-0644 CLOTH 1.30 g TOPICAL OTC monograph not final 12 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0651 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Hand Wash HUMAN OTC DRUG LABEL 1 0363-0683 LIQUID 1.30 mg TOPICAL OTC monograph not final 11 sections
First Aid AntisepticWell at Walgreens HUMAN OTC DRUG LABEL 2 0363-3286 SPRAY 0.13 g TOPICAL OTC monograph not final 11 sections
4x Medicated Toothache and Gum Gel HUMAN OTC DRUG LABEL 4 0363-6008 GEL 0.13 g ORAL OTC monograph not final 10 sections
Antiseptic HUMAN OTC DRUG LABEL 1 0363-7110 LIQUID 1.25 g TOPICAL OTC monograph not final 11 sections
STUDIO 35 BEAUTYAMBER ANTIBACTERIAL REFILL HUMAN OTC DRUG LABEL 1 0363-7210 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
WalgreensANTIBACTERIAL HAND REFILL HUMAN OTC DRUG LABEL 1 0363-7211 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
STUDIO 35AMBER HUMAN OTC DRUG LABEL 1 0363-7215 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Antiseptic Pain Relieving HUMAN OTC DRUG LABEL 2 0363-7779 SPRAY 0.10 g TOPICAL OTC monograph not final 7 sections
Walgreens HUMAN OTC DRUG LABEL 2 0363-7950 SPRAY 0.13 g TOPICAL OTC monograph not final 12 sections
Walgreens Fresh Antibacterial Foaming Hand HUMAN OTC DRUG LABEL 1 0363-9000 SOAP 1.30 mg TOPICAL OTC monograph not final 12 sections
Walgreens Citrus Antibacterial Foaming Hand HUMAN OTC DRUG LABEL 1 0363-9002 SOAP 1.30 mg TOPICAL OTC monograph not final 12 sections
HUMCO Merthiolate HUMAN OTC DRUG LABEL 1 0395-8010 LIQUID 1.30 mg TOPICAL OTC monograph not final 13 sections
Merthiolate HUMAN OTC DRUG LABEL 1 0395-9122 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0404-4445 LIQUID 7.49 g TOPICAL OTC monograph not final 11 sections
BZK Towelette HUMAN OTC DRUG LABEL 1 0404-5824 SWAB 0.00 mL TOPICAL OTC monograph not final 8 sections
BZK HUMAN OTC DRUG LABEL 1 0404-6735 LIQUID 0.00 g TOPICAL OTC monograph not final 11 sections
NORTH Antiseptic First Aid HUMAN OTC DRUG LABEL 2 0498-0016 SPRAY, METERED 107.10 mg TOPICAL OTC monograph not final 10 sections
North Antiseptic HUMAN OTC DRUG LABEL 1 0498-0401 SPRAY 0.13 g TOPICAL OTC monograph not final 14 sections
Antiseptic HUMAN OTC DRUG LABEL 1 0498-0402 SPRAY 0.13 g TOPICAL OTC monograph not final 14 sections
Antiseptic Towelette HUMAN OTC DRUG LABEL 1 0498-0501 LIQUID 1.30 mg TOPICAL OTC monograph not final 12 sections
First Aid Burn HUMAN OTC DRUG LABEL 2 0498-0903 CREAM 0.13 g TOPICAL OTC monograph not final 13 sections