Stem definition | Drug id | CAS RN |
---|---|---|
4376 | 6707-58-0 |
Dose | Unit | Route |
---|---|---|
20 | mg | V |
1.50 | mg | O |
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Inflammatory marker increased | 94.96 | 59.48 | 19 | 394 | 5456 | 46680193 |
Irritable bowel syndrome | 74.07 | 59.48 | 19 | 394 | 16496 | 46669153 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|
Source | Code | Description |
---|---|---|
ATC | D08AH01 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quinoline derivatives |
ATC | G01AC05 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Quinoline derivatives |
ATC | R02AA02 | RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000891 | Anti-Infective Agents, Local |
CHEBI has role | CHEBI:35610 | cytostatic |
CHEBI has role | CHEBI:35718 | antifungal drug |
CHEBI has role | CHEBI:38498 | mitochondrial complex i inhibitors |
CHEBI has role | CHEBI:48218 | antiseptics |
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.92 | Basic |
pKa2 | 4.32 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Small conductance calcium-activated potassium channel protein 1 | Ion channel | BLOCKER | IC50 | 6.40 | IUPHAR | ||||
Small conductance calcium-activated potassium channel protein 3 | Ion channel | IC50 | 5.89 | CHEMBL | |||||
Protein kinase C alpha type | Kinase | IC50 | 4.96 | CHEMBL | |||||
cGMP-gated cation channel alpha-1 | Unclassified | BLOCKER | IC50 | 6.70 | IUPHAR | ||||
Cyclic nucleotide-gated olfactory channel | Unclassified | BLOCKER | IC50 | 5.60 | IUPHAR | ||||
Small conductance calcium-activated potassium channel protein 3 | Ion channel | Ki | 6.85 | CHEMBL | |||||
Small conductance calcium-activated potassium channel protein 2 | Unclassified | BLOCKER | IC50 | 6.80 | IUPHAR |
ID | Source |
---|---|
D01575 | KEGG_DRUG |
N0000166911 | NUI |
522-51-0 | SECONDARY_CAS_RN |
C0011588 | UMLSCUI |
CHEBI:31466 | CHEBI |
DEQ | PDB_CHEM_ID |
CHEMBL333826 | ChEMBL_ID |
CHEMBL121663 | ChEMBL_ID |
DB04209 | DRUGBANK_ID |
D003868 | MESH_DESCRIPTOR_UI |
2993 | PUBCHEM_CID |
2313 | IUPHAR_LIGAND_ID |
746 | INN_ID |
E7QC7V26B8 | UNII |
3120 | RXNORM |
003481 | NDDF |
004966 | NDDF |
350274005 | SNOMEDCT_US |
395964006 | SNOMEDCT_US |
396013001 | SNOMEDCT_US |
None