Target Card Uniprot Example: P23975

dequalinium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4376	6707-58-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dequalinium dequalinium chloride dequalinium dichloride	A topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration. Molecular weight: 456.68 Formula: C30H40N4 CLOGP: -2.95 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 59.80 ALOGS: -9.04 ROTB: 11

Drug dosage:

Dose	Unit	Route
20	mg	V
1.50	mg	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Inflammatory marker increased	103.06	69.60	20	373	5614	50599117

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Inflammatory marker increased	65.87	47.01	14	350	8437	64489931

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AH01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quinoline derivatives
ATC	G01AC05	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Quinoline derivatives
ATC	R02AA02	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:35718	antifungal agents
CHEBI has role	CHEBI:38498	mitochondrial complex I inhibitors
CHEBI has role	CHEBI:48218	antiseptics

Drug Use (View source of the data)

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.92	Basic
pKa2	4.32	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Protein kinase C alpha type	Kinase	P17252	KPCA_HUMAN		IC50	4.96		CHEMBL
Small conductance calcium-activated potassium channel protein 3	Ion channel	Q9UGI6	KCNN3_HUMAN		IC50	5.89		CHEMBL
Small conductance calcium-activated potassium channel protein 1	Ion channel	Q92952	KCNN1_HUMAN	BLOCKER	IC50	6.40		IUPHAR
cGMP-gated cation channel alpha-1	Ion channel	P29973	CNGA1_HUMAN	BLOCKER	IC50	6.70		IUPHAR
Cyclic nucleotide-gated olfactory channel	Ion channel	Q16280	CNGA2_HUMAN	BLOCKER	IC50	5.60		IUPHAR
Small conductance calcium-activated potassium channel protein 3	Ion channel		KCNN3_RAT		Ki	6.85		CHEMBL
Small conductance calcium-activated potassium channel protein 2	Ion channel		KCNN2_RAT	BLOCKER	IC50	6.80		IUPHAR

External reference:

ID	Source
D01575	KEGG_DRUG
N0000166911	NUI
522-51-0	SECONDARY_CAS_RN
C0011588	UMLSCUI
CHEBI:31466	CHEBI
DEQ	PDB_CHEM_ID
CHEMBL333826	ChEMBL_ID
DB04209	DRUGBANK_ID
2313	IUPHAR_LIGAND_ID
E7QC7V26B8	UNII
2993	PUBCHEM_CID
3120	RXNORM
003481	NDDF
004966	NDDF
350274005	SNOMEDCT_US
395964006	SNOMEDCT_US
396013001	SNOMEDCT_US
D003868	MESH_DESCRIPTOR_UI
CHEMBL121663	ChEMBL_ID
746	INN_ID

Pharmaceutical products:

None