dibrompropamidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	3137	496-00-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dibrompropamidine
dibromopropamidine
dibrompropamidine hydrochloride
dibrompropamidine HCl
dibromopropamidine isethionate
dibromopropamidine isetionate
dibropropamidine isethionate
dibrompropamidine isetionate
dibrompropamidine isethionate
dibrompropamidine diisetionate

Molecular weight: 470.17
Formula: C17H18Br2N4O2
CLOGP: 2.96
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 118.20
ALOGS: -4.55
ROTB: 8

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FGFR1,FLT3,GRK2,GSK3B,IGF1R,IKBKB,INSR,ITK,JAK1,JAK2,JAK3,KIT,MAP2K1,MAP2K6,MAP3K1,MAP3K10,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70	86
kinase-selectivity-class	AXL,BRAF,CAMK2D,DYRK1B,ERBB2,MAP3K21,MAPK7,PDK4,PIK3CG,SIK2,SIK3,STK33	12
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AC01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Biguanides and amidines
ATC	S01AX14	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Other antiinfectives
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
CHEBI has role	CHEBI:66981	ophthalmology drug

Related Drugs by ATC class:

D08AC Biguanides and amidines 4 drugs

chlorhexidine hexamidine polihexanide propamidine

S01AX Other antiinfectives 13 drugs

bibrocathol cethexonium chlorhexidine hexamidine lotilaner nitrofurazone picloxydine polihexanide povidone-iodine propamidine resorcinol sodium borate show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.38	Basic
pKa2	10.78	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Urokinase-type plasminogen activator	Enzyme	P00749	UROK_HUMAN		Ki	5.80		CHEMBL
Prothrombin	Enzyme	P00734	THRB_HUMAN		Ki	6.02		CHEMBL
Suppressor of tumorigenicity 14 protein	Enzyme	Q9Y5Y6	ST14_HUMAN		Ki	6.27		CHEMBL
Acrosin	Enzyme		ACRO_PIG		Ki	5.77		CHEMBL

External reference:

ID	Source
D07204	KEGG_DRUG
C0057799	UMLSCUI
CHEBI:135760	CHEBI
CHEMBL30044	ChEMBL_ID
DB13548	DRUGBANK_ID
C053597	MESH_SUPPLEMENTAL_RECORD_UI
450	INN_ID
269M3QL74S	UNII
11974	PUBCHEM_CID
22862	RXNORM
005171	NDDF
005172	NDDF
396021007	SNOMEDCT_US
398837005	SNOMEDCT_US
422170002	SNOMEDCT_US
614-87-9	SECONDARY_CAS_RN

Pharmaceutical products:

None