picloxydine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3467 5636-92-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • picloxydine dihydrochloride
  • picloxydine hydrochloride
  • picloxydine HCl
  • vitabact
  • picloxydine
  • Molecular weight: 475.38
  • Formula: C20H24Cl2N10
  • CLOGP: 4.40
  • LIPINSKI: 1
  • HAC: 10
  • HDO: 8
  • TPSA: 150
  • ALOGS: -3.92
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.249 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 18.664 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.733 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 8.185 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 0.460 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 10.450 % High 1
herg hERG pIC50 4.935 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 28.510 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 16.788 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 1.120 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,KIT,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK12,MAPK7,MAPK9,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 62
kinase-selectivity-class ACVR2A,ACVR2B,AXL,CDK9,DDR1,DYRK1B,EIF2AK3,GRK2,MAPK12,MAPK7,PDK4,SIK2,STK33,TEK,TTK 15
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 6.324 High 1
mh-clint Mouse hepatocyte intrinsic clearance 9.705 High 1
mppb Mouse plasma protein binding (% unbound) 0.840 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 23.014 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 3.730 % High 1
rh-clint Rat hepatocyte intrinsic clearance 6.561 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 5.650 % High 1
rppb Rat plasma protein binding (% unbound) 1.170 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 411.150 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01AX16 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Other antiinfectives
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

S01AX Other antiinfectives 13 drugs
bibrocatholcethexoniumchlorhexidinedibrompropamidinehexamidinelotilanernitrofurazonepolihexanidepovidone-iodinepropamidineresorcinolsodium borate show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.31 Basic
pKa2 11.71 Basic
pKa3 2.17 Basic
pKa4 1.56 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Acetylcholinesterase Enzyme Ki 4.66 CHEMBL
Cholinesterase Enzyme Ki 6.21 CHEMBL

External reference:

IDSource
D07415 KEGG_DRUG
19803-62-4 SECONDARY_CAS_RN
C0071036 UMLSCUI
CHEBI:135768 CHEBI
CHEMBL2104722 ChEMBL_ID
DB13607 DRUGBANK_ID
C005253 MESH_SUPPLEMENTAL_RECORD_UI
1519 INN_ID
4YC2PY3AEU UNII
5748610 PUBCHEM_CID
005716 NDDF
005717 NDDF
717152000 SNOMEDCT_US
735171009 SNOMEDCT_US

Pharmaceutical products:

None