All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

ipratropium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
atropine derivatives	1475	60205-81-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: ipratropium ipratropium bromide ipratropium bromide hydrate ipratropium bromide monohydrate	A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic. Molecular weight: 332.46 Formula: C20H30NO3 CLOGP: -2.19 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 46.53 ALOGS: -5.48 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.24	mg	N
0.12	mg	Inhal.aerosol
0.12	mg	Inhal.powder
0.30	mg	Inhal.solution

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.01 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	3 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	5.10 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	31.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.95 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1.64 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Dec. 29, 1986	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	1287.45	10.87	1005	56755	126556	63304706
Wheezing	829.22	10.87	690	57070	94905	63336357
Obstructive airways disorder	580.70	10.87	311	57449	20388	63410874
Chronic obstructive pulmonary disease	494.91	10.87	429	57331	62257	63369005
Dyspnoea	480.94	10.87	1502	56258	659811	62771451
Sleep disorder due to a general medical condition	341.40	10.87	183	57577	12005	63419257
Pneumonia	254.40	10.87	951	56809	455816	62975446
Cough	254.23	10.87	710	57050	292033	63139229
Productive cough	245.35	10.87	295	57465	62913	63368349
Chest discomfort	222.52	10.87	376	57384	109593	63321669
Full blood count abnormal	222.16	10.87	203	57557	31514	63399748
Drug intolerance	186.52	10.87	29	57731	308632	63122630
Alopecia	161.53	10.87	53	57707	337483	63093779
Contraindicated product administered	161.50	10.87	9	57751	217639	63213623
Synovitis	144.22	10.87	6	57754	186912	63244350
Systemic lupus erythematosus	142.47	10.87	13	57747	208905	63222357
Drug ineffective	139.04	10.87	488	57272	1044277	62386985
Pemphigus	138.16	10.87	7	57753	183719	63247543
Asthma-chronic obstructive pulmonary disease overlap syndrome	132.73	10.87	55	57705	2006	63429256
Glossodynia	130.84	10.87	8	57752	178868	63252394
Nasal congestion	124.17	10.87	218	57542	65442	63365820
Total lung capacity increased	123.43	10.87	54	57706	2256	63429006
Sputum discoloured	123.06	10.87	109	57651	16238	63415024
Arthropathy	121.14	10.87	32	57728	234760	63196502
Treatment failure	119.47	10.87	19	57741	199024	63232238
Bronchiectasis	118.28	10.87	106	57654	16036	63415226
Therapeutic product effect incomplete	116.86	10.87	312	57448	124744	63306518
Completed suicide	114.67	10.87	4	57756	145669	63285593
Respiratory failure	113.83	10.87	272	57488	101586	63329676
Rheumatoid arthritis	111.00	10.87	46	57714	253773	63177489
Cardiac murmur	109.48	10.87	97	57663	14455	63416807
Dyspnoea exertional	108.60	10.87	196	57564	60106	63371156
Nasal polyps	106.10	10.87	67	57693	5972	63425290
Breath sounds abnormal	104.95	10.87	84	57676	10889	63420373
Middle insomnia	104.66	10.87	89	57671	12554	63418708
Wound	104.02	10.87	13	57747	163250	63268012
Sleep apnoea syndrome	101.74	10.87	129	57631	29004	63402258
Loss of personal independence in daily activities	96.25	10.87	248	57512	97042	63334220
Bronchial neoplasm	91.96	10.87	29	57731	471	63430791
Nasal turbinate hypertrophy	91.29	10.87	32	57728	731	63430531
Joint swelling	90.32	10.87	99	57661	327567	63103695
Rales	90.31	10.87	82	57678	12615	63418647
Infusion related reaction	90.14	10.87	56	57704	245465	63185797
Gastrooesophageal reflux disease	88.70	10.87	238	57522	95401	63335861
Pericarditis	87.52	10.87	9	57751	131570	63299692
Bronchial haemorrhage	87.14	10.87	29	57731	563	63430699
Off label use	86.68	10.87	319	57441	674143	62757119
Vocal cord dysfunction	84.85	10.87	28	57732	529	63430733
Maternal exposure during pregnancy	83.86	10.87	48	57712	220014	63211248
Hyper IgE syndrome	83.19	10.87	27	57733	483	63430779
Blood test abnormal	83.05	10.87	86	57674	15543	63415719
Rhinitis allergic	81.97	10.87	75	57685	11652	63419610
Discomfort	80.45	10.87	26	57734	167348	63263914
Bronchitis	80.10	10.87	273	57487	124662	63306600
Toxicity to various agents	79.47	10.87	65	57695	247185	63184077
Abdominal discomfort	78.84	10.87	106	57654	320779	63110483
Rhonchi	78.70	10.87	41	57719	2535	63428727
Therapeutic product effect decreased	78.20	10.87	39	57721	193148	63238114
Ventricular failure	77.87	10.87	24	57736	360	63430902
Acute respiratory failure	77.86	10.87	124	57636	34361	63396901
Sarcoidosis	75.63	10.87	58	57702	7064	63424198
Respiration abnormal	74.22	10.87	55	57705	6362	63424900
Upper-airway cough syndrome	73.97	10.87	70	57690	11348	63419914
Blood immunoglobulin E increased	73.42	10.87	45	57715	3804	63427458
Endometrial ablation	73.34	10.87	29	57731	935	63430327
Arthralgia	72.76	10.87	270	57490	569440	62861822
Anti-cyclic citrullinated peptide antibody positive	72.22	10.87	10	57750	116202	63315060
Oesophageal spasm	71.30	10.87	41	57719	3082	63428180
Hypercapnia	70.68	10.87	50	57710	5381	63425881
Total lung capacity decreased	70.30	10.87	36	57724	2147	63429115
Prolonged expiration	69.74	10.87	29	57731	1067	63430195
Eosinophilia	68.98	10.87	94	57666	22662	63408600
Swelling	68.61	10.87	90	57670	275288	63155974
Pain	68.53	10.87	395	57365	740233	62691029
Bronchospasm	67.56	10.87	81	57679	17199	63414063
Haemoptysis	67.21	10.87	105	57655	28621	63402641
Hypoxia	67.11	10.87	160	57600	59632	63371630
Rhinitis	66.71	10.87	66	57694	11300	63419962
Helicobacter infection	65.34	10.87	5	57755	92780	63338482
Forced expiratory volume decreased	65.26	10.87	46	57714	4922	63426340
Bronchial disorder	65.19	10.87	29	57731	1261	63430001
Restrictive pulmonary disease	64.85	10.87	32	57728	1763	63429499
Upper respiratory tract infection	64.16	10.87	192	57568	81855	63349407
Rib deformity	63.25	10.87	19	57741	260	63431002
Oesophageal pain	62.37	10.87	40	57720	3661	63427601
Heart sounds	62.19	10.87	26	57734	970	63430292
Myocardial infarction	60.29	10.87	214	57546	99679	63331583
Rash	57.97	10.87	288	57472	560583	62870679
Bronchopulmonary aspergillosis allergic	57.93	10.87	32	57728	2226	63429036
Laryngeal stenosis	56.94	10.87	25	57735	1053	63430209
Throat clearing	55.87	10.87	32	57728	2387	63428875
Oxygen saturation decreased	54.51	10.87	191	57569	88394	63342868
Breast conserving surgery	54.35	10.87	24	57736	1025	63430237
Sinus disorder	53.66	10.87	87	57673	24466	63406796
Dysphonia	51.91	10.87	126	57634	47488	63383774
Exposure during pregnancy	51.06	10.87	40	57720	155507	63275755
Tachypnoea	50.22	10.87	70	57690	17232	63414030
Psoriatic arthropathy	50.04	10.87	11	57749	91509	63339753
Blister	48.45	10.87	29	57731	129785	63301477
Product use issue	48.12	10.87	79	57681	220441	63210821
PO2 decreased	46.09	10.87	24	57736	1482	63429780
Jaundice cholestatic	45.73	10.87	44	57716	7280	63423982
Hepatic enzyme increased	45.54	10.87	71	57689	202257	63229005
Irritable bowel syndrome	44.87	10.87	10	57750	82402	63348860
Lung neoplasm malignant	43.50	10.87	70	57690	19563	63411699
Lower respiratory tract infection	43.38	10.87	236	57524	132071	63299191
Hypomania	43.30	10.87	40	57720	6290	63424972
Lung opacity	43.17	10.87	30	57730	3138	63428124
Nasal obstruction	42.95	10.87	24	57736	1707	63429555
Sight disability	42.42	10.87	12	57748	131	63431131
PCO2 increased	41.55	10.87	21	57739	1218	63430044
Sinus tachycardia	41.29	10.87	77	57683	24191	63407071
Respiratory rate increased	40.79	10.87	56	57704	13592	63417670
Oedema peripheral	40.41	10.87	303	57457	189208	63242054
Respiratory disorder	40.04	10.87	101	57659	38981	63392281
Lymphoedema	39.59	10.87	51	57709	11641	63419621
Aspiration	39.39	10.87	49	57711	10802	63420460
Intentional product use issue	39.36	10.87	35	57725	127857	63303405
Venous pressure jugular increased	39.20	10.87	16	57744	561	63430701
Thermohypoaesthesia	38.73	10.87	11	57749	122	63431140
Influenza B virus test positive	38.70	10.87	13	57747	260	63431002
Lung hyperinflation	37.82	10.87	20	57740	1275	63429987
Cardiac failure congestive	37.42	10.87	175	57585	92258	63339004
Impaired healing	36.75	10.87	24	57736	102518	63328744
Granuloma	36.71	10.87	35	57725	5726	63425536
Reversible airways obstruction	36.32	10.87	22	57738	1820	63429442
Sleep disorder due to general medical condition, insomnia type	36.24	10.87	3	57757	52214	63379048
Infective exacerbation of chronic obstructive airways disease	35.54	10.87	19	57741	1238	63430024
Status asthmaticus	35.31	10.87	17	57743	887	63430375
Drug abuse	35.30	10.87	11	57749	72507	63358755
Blood insulin abnormal	35.18	10.87	8	57752	32	63431230
FEV1/FVC ratio decreased	34.96	10.87	10	57750	114	63431148
Tracheomalacia	34.36	10.87	11	57749	188	63431074
Pulmonary hypertension	34.00	10.87	92	57668	37031	63394231
Infective pulmonary exacerbation of cystic fibrosis	33.92	10.87	41	57719	8776	63422486
Airway peak pressure increased	33.87	10.87	12	57748	283	63430979
Respiratory distress	32.98	10.87	86	57674	33865	63397397
Dyslipidaemia	32.82	10.87	37	57723	7356	63423906
Multimorbidity	32.11	10.87	14	57746	580	63430682
Polycystic ovaries	32.04	10.87	29	57731	4442	63426820
Respiratory tract infection	31.40	10.87	96	57664	41387	63389875
Affective disorder	31.18	10.87	33	57727	6113	63425149
Heart rate increased	30.81	10.87	168	57592	94070	63337192
Pneumonia viral	30.74	10.87	37	57723	7885	63423377
Diarrhoea	30.47	10.87	463	57297	714903	62716359
Respiratory gas exchange disorder	30.37	10.87	12	57748	386	63430876
Depressive symptom	30.17	10.87	27	57733	4075	63427187
Skin lesion	30.03	10.87	78	57682	30643	63400619
Hip arthroplasty	29.83	10.87	4	57756	47642	63383620
Bundle branch block left	29.09	10.87	34	57726	7025	63424237
C-reactive protein abnormal	28.55	10.87	4	57756	46092	63385170
Schizophrenia	28.49	10.87	40	57720	9912	63421350
Coronary artery disease	27.44	10.87	78	57682	32299	63398963
Fatigue	27.42	10.87	608	57152	887420	62543842
Drug hypersensitivity	27.36	10.87	168	57592	310519	63120743
Atrial fibrillation	26.85	10.87	190	57570	116446	63314816
Red blood cell sedimentation rate increased	26.81	10.87	4	57756	43978	63387284
Gastrointestinal disorder	26.80	10.87	49	57711	131190	63300072
Lactose intolerance	26.79	10.87	22	57738	2956	63428306
Cyanosis	26.67	10.87	52	57708	16883	63414379
Asthmatic crisis	26.67	10.87	18	57742	1795	63429467
Liver injury	26.36	10.87	11	57749	60509	63370753
Separation anxiety disorder	26	10.87	6	57754	26	63431236
Chest X-ray abnormal	25.92	10.87	26	57734	4523	63426739
Kyphosis	25.48	10.87	20	57740	2520	63428742
Respiratory acidosis	25.47	10.87	31	57729	6684	63424578
Toxic epidermal necrolysis	25.46	10.87	65	57695	25269	63405993
Crystal arthropathy	25.18	10.87	10	57750	326	63430936
Blood pH decreased	25.15	10.87	20	57740	2567	63428695
Appetite disorder	24.89	10.87	32	57728	7289	63423973
Sinusitis	24.78	10.87	315	57445	226338	63204924
Liver disorder	24.63	10.87	9	57751	53678	63377584
Intentional overdose	24.41	10.87	19	57741	74133	63357129
Rhinorrhoea	24.26	10.87	121	57639	65456	63365806
Blood cholesterol increased	24.14	10.87	30	57730	94002	63337260
Haematoma	23.98	10.87	78	57682	34742	63396520
Heparin-induced thrombocytopenia	23.96	10.87	25	57735	4557	63426705
Unresponsive to stimuli	23.51	10.87	76	57684	33740	63397522
Knee arthroplasty	23.37	10.87	10	57750	54196	63377066
Abortion spontaneous	23.25	10.87	7	57753	47188	63384074
Blood bicarbonate decreased	22.91	10.87	20	57740	2921	63428341
Emphysema	22.88	10.87	38	57722	10900	63420362
Influenza	22.68	10.87	173	57587	108549	63322713
Acute generalised exanthematous pustulosis	22.47	10.87	38	57722	11061	63420201
Amaurosis	22.43	10.87	11	57749	598	63430664
Lung disorder	22.41	10.87	114	57646	62147	63369115
Febrile neutropenia	21.79	10.87	47	57713	118402	63312860
Pulmonary function test decreased	21.47	10.87	22	57738	3925	63427337
Rectal prolapse	20.73	10.87	16	57744	1967	63429295
Oesophageal motility disorder	20.52	10.87	9	57751	378	63430884
Brain hypoxia	20.52	10.87	10	57750	536	63430726
Peripheral swelling	20.31	10.87	150	57610	265792	63165470
Optic ischaemic neuropathy	20.08	10.87	13	57747	1209	63430053
Eosinophil count abnormal	19.82	10.87	10	57750	578	63430684
Blood lactic acid increased	19.57	10.87	28	57732	7058	63424204
Adverse event	19.02	10.87	20	57740	67539	63363723
Peak expiratory flow rate abnormal	18.94	10.87	6	57754	99	63431163
Stress cardiomyopathy	18.66	10.87	32	57728	9418	63421844
Angina pectoris	18.61	10.87	65	57695	30013	63401249
Mobility decreased	18.45	10.87	53	57707	121106	63310156
Frustration tolerance decreased	18.41	10.87	27	57733	6961	63424301
Pupillary reflex impaired	18.16	10.87	15	57745	2032	63429230
Upper airway obstruction	18.14	10.87	10	57750	693	63430569
Hypoventilation	18.11	10.87	22	57738	4732	63426530
Upper respiratory tract irritation	18.11	10.87	7	57753	212	63431050
Injection site reaction	18.02	10.87	16	57744	58508	63372754
Premature delivery	17.90	10.87	3	57757	30278	63400984
Humidity intolerance	17.85	10.87	8	57752	354	63430908
Blood calcium increased	17.60	10.87	31	57729	9319	63421943
Sneezing	17.54	10.87	46	57714	18172	63413090
Dystrophic calcification	17.50	10.87	6	57754	128	63431134
Pulmonary oedema	17.37	10.87	97	57663	54776	63376486
Infusion site erythema	17.36	10.87	35	57725	11644	63419618
Seasonal allergy	17.29	10.87	50	57710	20900	63410362
Pneumonia staphylococcal	17.21	10.87	17	57743	2903	63428359
Musculoskeletal stiffness	17.20	10.87	98	57662	184520	63246742
Presyncope	17.15	10.87	60	57700	27725	63403537
Neuromyelitis optica spectrum disorder	16.99	10.87	11	57749	1023	63430239
Pneumonia respiratory syncytial viral	16.84	10.87	11	57749	1039	63430223
Pulmonary mass	16.82	10.87	52	57708	22544	63408718
Chest pain	16.81	10.87	283	57477	215676	63215586
Nephrocalcinosis	16.57	10.87	11	57749	1067	63430195
Staphylococcus test positive	16.45	10.87	19	57741	3877	63427385
Psoriasis	16.42	10.87	34	57726	86923	63344339
Infusion site extravasation	16.40	10.87	32	57728	10394	63420868
Disease progression	16.37	10.87	57	57703	122701	63308561
Oropharyngeal discomfort	16.35	10.87	22	57738	5238	63426024
Forced expiratory volume increased	16.25	10.87	4	57756	24	63431238
Chronic sinusitis	16.20	10.87	36	57724	12807	63418455
Injection site pain	16.17	10.87	62	57698	129738	63301524
Injection site bruising	16.14	10.87	9	57751	41901	63389361
Nausea	15.57	10.87	628	57132	853843	62577419
Tinnitus	15.56	10.87	69	57691	35559	63395703
Infusion site haemorrhage	15.39	10.87	21	57739	5065	63426197
Decreased appetite	15.38	10.87	150	57610	250902	63180360
Malaise	15.15	10.87	490	57270	415464	63015798
Pancytopenia	15.05	10.87	42	57718	96891	63334371
Abscess	14.95	10.87	41	57719	16627	63414635
Idiopathic angioedema	14.64	10.87	4	57756	38	63431224
Extensor plantar response	14.63	10.87	11	57749	1300	63429962
Acute myocardial infarction	14.63	10.87	63	57697	32061	63399201
Respiratory alkalosis	14.59	10.87	15	57745	2686	63428576
Glycosylated haemoglobin decreased	14.46	10.87	8	57752	558	63430704
Stomatitis	14.39	10.87	71	57689	138654	63292608
Hepatic function abnormal	14.27	10.87	8	57752	37134	63394128
Respiratory tract congestion	14.18	10.87	42	57718	17790	63413472
Sputum purulent	14.13	10.87	10	57750	1077	63430185
Inflammation	14.03	10.87	34	57726	82239	63349023
Infusion site pruritus	14.03	10.87	22	57738	6013	63425249
White blood cell count decreased	13.97	10.87	72	57688	139032	63292230
Eye pruritus	13.93	10.87	43	57717	18628	63412634
Hypoaesthesia	13.81	10.87	93	57667	168300	63262962
Vascular parkinsonism	13.77	10.87	5	57755	127	63431135
Lactic acidosis	13.70	10.87	70	57690	38217	63393045
Eczema	13.70	10.87	62	57698	32229	63399033
Peak expiratory flow rate decreased	13.67	10.87	8	57752	621	63430641
Hyperlipidaemia	13.62	10.87	44	57716	19527	63411735
Foetal exposure during pregnancy	13.61	10.87	6	57754	31956	63399306
Idiopathic intracranial hypertension	13.58	10.87	15	57745	2916	63428346
Agitation	13.54	10.87	97	57663	59660	63371602
Type 2 diabetes mellitus	13.52	10.87	102	57658	63766	63367496
Tremor	13.27	10.87	181	57579	132058	63299204
Chondrocalcinosis pyrophosphate	13.26	10.87	10	57750	1188	63430074
Laryngospasm	13.18	10.87	15	57745	3013	63428249
Pneumonia haemophilus	13.15	10.87	8	57752	667	63430595
Multiple sclerosis relapse	12.93	10.87	15	57745	48463	63382799
Hypersensitivity	12.89	10.87	188	57572	292497	63138765
Hypertrophic cardiomyopathy	12.78	10.87	11	57749	1576	63429686
Anxiety	12.77	10.87	273	57487	217268	63213994
Pharyngeal mass	12.72	10.87	6	57754	299	63430963
Sedation	12.70	10.87	10	57750	38799	63392463
Cardiomegaly	12.62	10.87	40	57720	17574	63413688
C-reactive protein increased	12.61	10.87	44	57716	94663	63336599
Flank pain	12.44	10.87	38	57722	16372	63414890
Inspiratory capacity decreased	12.41	10.87	4	57756	70	63431192
Ankle fracture	12.30	10.87	40	57720	17815	63413447
Hyperlactacidaemia	12.21	10.87	14	57746	2835	63428427
Musculoskeletal pain	12.20	10.87	43	57717	92234	63339028
Visceral pain	12.19	10.87	3	57757	18	63431244
Blood glucose abnormal	12.15	10.87	24	57736	7868	63423394
Frequent bowel movements	12.12	10.87	3	57757	23019	63408243
Anaphylactic reaction	12.05	10.87	102	57658	65998	63365264
Blood albumin decreased	11.95	10.87	35	57725	14731	63416531
Vocal cord disorder	11.93	10.87	10	57750	1383	63429879
Infusion site bruising	11.87	10.87	16	57744	3816	63427446
Forced expiratory volume abnormal	11.82	10.87	4	57756	82	63431180
Pneumonia pseudomonal	11.80	10.87	13	57747	2520	63428742
Bone marrow failure	11.71	10.87	6	57754	29284	63401978
Facial discomfort	11.59	10.87	4	57756	87	63431175
Tachycardia	11.56	10.87	161	57599	117995	63313267
Generalised tonic-clonic seizure	11.51	10.87	6	57754	29010	63402252
Impaired quality of life	11.48	10.87	33	57727	13750	63417512
Pulmonary pain	11.47	10.87	15	57745	3475	63427787
Restless legs syndrome	11.42	10.87	40	57720	18491	63412771
Pulmonary embolism	11.42	10.87	159	57601	116525	63314737
Angle closure glaucoma	11.41	10.87	12	57748	2207	63429055
Fluid retention	11.35	10.87	93	57667	59593	63371669
Foreign body sensation in eyes	11.34	10.87	12	57748	2222	63429040
Drug eruption	11.29	10.87	6	57754	28688	63402574
Breathing-related sleep disorder	11.26	10.87	4	57756	95	63431167
Cardiac disorder	11.23	10.87	82	57678	50734	63380528
Hiatus hernia	11.13	10.87	44	57716	21550	63409712
Barrett's oesophagus	11.04	10.87	7	57753	628	63430634
Tongue exfoliation	11.00	10.87	4	57756	102	63431160
Prescribed overdose	10.92	10.87	9	57751	34144	63397118
Tumour hyperprogression	10.89	10.87	4	57756	105	63431157

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	699.67	11.82	511	43180	42145	34871095
Wheezing	548.83	11.82	437	43254	40965	34872275
Chronic obstructive pulmonary disease	467.56	11.82	428	43263	48490	34864750
Obstructive airways disorder	453.62	11.82	267	43424	15227	34898013
Dyspnoea	330.60	11.82	1125	42566	375657	34537583
Asthma-chronic obstructive pulmonary disease overlap syndrome	269.88	11.82	89	43602	1198	34912042
Appendicolith	240.62	11.82	144	43547	8457	34904783
Full blood count abnormal	193.19	11.82	171	43520	18497	34894743
Appendicitis	182.58	11.82	150	43541	14657	34898583
Stress	174.09	11.82	202	43489	30145	34883095
Sputum discoloured	168.71	11.82	111	43580	7701	34905539
Cardiogenic shock	154.05	11.82	178	43513	26440	34886800
Cough	151.95	11.82	472	43219	149668	34763572
Bronchiectasis	135.09	11.82	106	43585	9695	34903545
Nasal obstruction	126.60	11.82	43	43648	637	34912603
Chest discomfort	125.60	11.82	236	43455	54294	34858946
Productive cough	123.25	11.82	191	43500	37622	34875618
Pulmonary function test decreased	120.52	11.82	76	43615	4899	34908341
Sinus pain	119.93	11.82	42	43649	685	34912555
Pneumonia	112.09	11.82	805	42886	361822	34551418
Ventricular fibrillation	110.75	11.82	140	43551	22814	34890426
Fractional exhaled nitric oxide increased	110.60	11.82	44	43647	1038	34912202
Blood phosphorus increased	101.03	11.82	81	43610	7640	34905600
Forced expiratory volume decreased	93.15	11.82	55	43636	3148	34910092
Eosinophilia	91.86	11.82	137	43554	26085	34887155
Drug abuse	86.37	11.82	11	43680	99085	34814155
Toxicity to various agents	85.35	11.82	75	43616	200287	34712953
Toxic epidermal necrolysis	84.42	11.82	119	43572	21527	34891713
Completed suicide	82.94	11.82	12	43679	98156	34815084
Lower respiratory tract infection	81.78	11.82	144	43547	31493	34881747
Mycobacterium avium complex infection	80.67	11.82	46	43645	2465	34910775
Plantar fasciitis	79.58	11.82	43	43648	2073	34911167
Multiple organ dysfunction syndrome	75.69	11.82	239	43452	76327	34836913
Emphysema	73.16	11.82	74	43617	9451	34903789
Myoglobin blood increased	72.77	11.82	46	43645	2977	34910263
Nasal congestion	71.67	11.82	114	43577	22943	34890297
Sensation of foreign body	71.15	11.82	44	43647	2739	34910501
Dyspnoea exertional	69.92	11.82	162	43529	43117	34870123
Bronchitis	69.92	11.82	159	43532	41804	34871436
Middle insomnia	69.72	11.82	62	43629	6740	34906500
Abdominal distension	69.59	11.82	195	43496	58297	34854943
Therapeutic product effect incomplete	68.69	11.82	177	43514	50364	34862876
Ascites	67.36	11.82	167	43524	46404	34866836
Brain natriuretic peptide increased	62.87	11.82	54	43637	5605	34907635
Secretion discharge	60.87	11.82	54	43637	5851	34907389
Oxygen saturation decreased	60.69	11.82	176	43515	53642	34859598
Lung consolidation	60.63	11.82	54	43637	5882	34907358
Respiratory distress	60.37	11.82	136	43555	35529	34877711
General physical health deterioration	59.03	11.82	316	43375	127953	34785287
Osteopenia	57.41	11.82	48	43643	4801	34908439
Respiratory failure	55.16	11.82	275	43416	108297	34804943
Sleep disorder due to a general medical condition	54.33	11.82	48	43643	5173	34908067
Respiratory disorder	54.12	11.82	91	43600	19173	34894067
Hyponatraemia	48.96	11.82	219	43472	82472	34830768
Painful respiration	48.96	11.82	26	43665	1210	34912030
Pulmonary function test abnormal	46.64	11.82	33	43658	2577	34910663
Myasthenia gravis	46.28	11.82	50	43641	6890	34906350
Eye disorder	44.18	11.82	57	43634	9471	34903769
Dry mouth	43.42	11.82	108	43583	30057	34883183
Throat irritation	42.46	11.82	59	43632	10526	34902714
Bronchial hyperreactivity	41.12	11.82	26	43665	1683	34911557
Blood uric acid increased	40.65	11.82	55	43636	9569	34903671
Tachypnoea	40.44	11.82	78	43613	18274	34894966
Chest injury	40.28	11.82	25	43666	1566	34911674
Diarrhoea	39.78	11.82	305	43386	389607	34523633
Pneumothorax	39.47	11.82	79	43612	19013	34894227
Pulmonary mass	37.97	11.82	62	43629	12750	34900490
Pleural thickening	37.08	11.82	15	43676	370	34912870
Bronchospasm	36.05	11.82	55	43636	10676	34902564
Pneumonitis	34.58	11.82	107	43584	33771	34879469
Exostosis	33.21	11.82	35	43656	4688	34908552
Constipation	33.15	11.82	288	43403	136694	34776546
Dysphonia	31.86	11.82	82	43609	23301	34889939
Drug therapy	31.63	11.82	19	43672	1122	34912118
Genital herpes simplex	31.44	11.82	10	43681	119	34913121
Foetal exposure during pregnancy	31.37	11.82	5	43686	38096	34875144
Walking aid user	31.35	11.82	23	43668	1901	34911339
Analgesic therapy	31.30	11.82	18	43673	980	34912260
Hypoventilation	30.85	11.82	29	43662	3385	34909855
Overdose	30.00	11.82	42	43649	91017	34822223
Diaphragmatic disorder	29.69	11.82	19	43672	1256	34911984
Hyperkaliuria	29.27	11.82	9	43682	95	34913145
Lung disorder	27.80	11.82	101	43590	34595	34878645
Sensitivity to weather change	27.77	11.82	20	43671	1606	34911634
Febrile neutropenia	25.99	11.82	86	43605	136763	34776477
White blood cell count decreased	25.87	11.82	50	43641	95395	34817845
Neuropathy peripheral	25.87	11.82	40	43651	83223	34830017
Malignant neoplasm progression	25.76	11.82	44	43647	88002	34825238
Use of accessory respiratory muscles	25.76	11.82	12	43679	420	34912820
Sleep disorder therapy	25.71	11.82	16	43675	1007	34912233
Total lung capacity abnormal	25.52	11.82	9	43682	150	34913090
Hypercapnia	25.51	11.82	29	43662	4226	34909014
Seasonal allergy	24.99	11.82	36	43655	6639	34906601
Hyperphosphataemia	24.53	11.82	29	43662	4408	34908832
Bronchitis viral	24.37	11.82	10	43681	256	34912984
Upper-airway cough syndrome	24.37	11.82	26	43665	3532	34909708
COVID-19 treatment	23.95	11.82	10	43681	268	34912972
Oral candidiasis	23.71	11.82	49	43642	12061	34901179
Ocular discomfort	22.97	11.82	20	43671	2114	34911126
Platelet count decreased	22.89	11.82	75	43616	119642	34793598
Breath sounds abnormal	22.73	11.82	35	43656	6846	34906394
Wolff-Parkinson-White syndrome	22.44	11.82	9	43682	217	34913023
Lung hyperinflation	22.43	11.82	14	43677	886	34912354
Iron deficiency	21.59	11.82	30	43661	5351	34907889
Off label use	21.59	11.82	382	43309	419142	34494098
Intentional overdose	21.56	11.82	14	43677	43660	34869580
Bronchial wall thickening	21.49	11.82	16	43675	1352	34911888
Drug ineffective	21.31	11.82	423	43268	456328	34456912
Hypoxia	20.88	11.82	129	43562	54966	34858274
Chronic respiratory failure	20.87	11.82	16	43675	1413	34911827
Influenza	20.56	11.82	119	43572	49547	34863693
Treatment failure	20.42	11.82	17	43674	46680	34866560
Blood immunoglobulin E decreased	20.37	11.82	6	43685	54	34913186
Aortic aneurysm	20.35	11.82	33	43658	6746	34906494
Type IIa hyperlipidaemia	20.06	11.82	8	43683	190	34913050
Blood immunoglobulin E increased	19.95	11.82	20	43671	2526	34910714
Dust allergy	19.86	11.82	13	43678	893	34912347
Rash	19.58	11.82	181	43510	222571	34690669
Inappropriate schedule of product administration	19.28	11.82	30	43661	62266	34850974
Hypohidrosis	19.24	11.82	8	43683	212	34913028
Neutropenia	19.21	11.82	116	43575	156662	34756578
Forced vital capacity decreased	19.16	11.82	12	43679	764	34912476
Incorrect route of product administration	19.13	11.82	51	43640	14794	34898446
Peak expiratory flow rate decreased	19.05	11.82	7	43684	132	34913108
Illness	19.00	11.82	48	43643	13481	34899759
Respiratory tract infection	18.96	11.82	61	43630	19651	34893589
Infective pulmonary exacerbation of cystic fibrosis	18.93	11.82	32	43659	6769	34906471
Tachycardia foetal	18.83	11.82	9	43682	334	34912906
Genital herpes	18.71	11.82	11	43680	624	34912616
Respiratory tract congestion	18.58	11.82	30	43661	6109	34907131
Respiratory acidosis	18.56	11.82	27	43664	5023	34908217
Aggression	18.55	11.82	13	43678	38951	34874289
Feeling cold	18.47	11.82	41	43650	10598	34902642
Disease progression	18.46	11.82	71	43620	108006	34805234
Rales	18.20	11.82	39	43652	9844	34903396
Atrial fibrillation	18.09	11.82	233	43458	122160	34791080
Drug resistance	18.07	11.82	5	43686	25922	34887318
Cardiac disorder	17.63	11.82	103	43588	43023	34870217
Blood cholesterol increased	17.48	11.82	61	43630	20482	34892758
Suicide attempt	17.40	11.82	14	43677	39102	34874138
Bilirubin conjugated abnormal	16.69	11.82	6	43685	106	34913134
Perfume sensitivity	16.59	11.82	6	43685	108	34913132
Haemoptysis	16.57	11.82	87	43604	34919	34878321
Sneezing	16.39	11.82	26	43665	5216	34908024
Diastolic hypotension	16.33	11.82	5	43686	52	34913188
Left ventricular hypertrophy	16.04	11.82	33	43658	8097	34905143
Bronchospasm paradoxical	15.91	11.82	5	43686	57	34913183
Reversible airways obstruction	15.82	11.82	9	43682	480	34912760
Sepsis	15.75	11.82	294	43397	166267	34746973
Injection related reaction	15.60	11.82	8	43683	346	34912894
Multiple allergies	15.57	11.82	19	43672	2984	34910256
Carbon dioxide increased	15.56	11.82	12	43679	1069	34912171
Back injury	15.43	11.82	22	43669	4019	34909221
Pancreatitis acute	15.33	11.82	8	43683	28133	34885107
Viral myelitis	15.32	11.82	5	43686	65	34913175
Headache	15.15	11.82	169	43522	200466	34712774
Ischaemic cardiomyopathy	15.12	11.82	28	43663	6361	34906879
Vital capacity decreased	14.83	11.82	8	43683	384	34912856
Conjunctivitis allergic	14.72	11.82	12	43679	1158	34912082
Product prescribing error	14.52	11.82	62	43629	22865	34890375
Occupational exposure to air contaminants	14.47	11.82	6	43685	158	34913082
Pruritus	14.43	11.82	111	43580	141870	34771370
Memory impairment	14.24	11.82	20	43671	43298	34869942
Fatigue	13.91	11.82	355	43336	370298	34542942
Respiratory rate increased	13.79	11.82	35	43656	9859	34903381
Psoriasis	13.70	11.82	17	43674	38795	34874445
Toxic optic neuropathy	13.48	11.82	10	43681	840	34912400
Cytomegalovirus infection	13.42	11.82	8	43683	26127	34887113
Acute respiratory failure	13.38	11.82	75	43616	30853	34882387
Pain	13.33	11.82	178	43513	204497	34708743
Premature baby	13.29	11.82	4	43687	19629	34893611
Cytokine release syndrome	13.23	11.82	6	43685	22871	34890369
Bone marrow oedema	13.19	11.82	9	43682	663	34912577
Status asthmaticus	13.14	11.82	7	43684	328	34912912
Subcutaneous emphysema	12.47	11.82	11	43680	1183	34912057
Medication error	12.42	11.82	64	43627	25501	34887739
Therapeutic response decreased	12.41	11.82	11	43680	29302	34883938
Lung opacity	12.35	11.82	15	43676	2344	34910896
Mycobacterial infection	12.28	11.82	15	43676	2359	34910881
Hyperaesthesia teeth	12.16	11.82	8	43683	554	34912686
Expiratory reserve volume decreased	12.05	11.82	4	43687	55	34913185
Cardiomyopathy	11.86	11.82	47	43644	16761	34896479
Gastrointestinal disorder	11.84	11.82	15	43676	33933	34879307

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	1620.56	10.55	1263	84523	133832	79524770
Wheezing	1072.03	10.55	935	84851	115729	79542873
Obstructive airways disorder	870.78	10.55	496	85290	30963	79627639
Chronic obstructive pulmonary disease	846.12	10.55	715	85071	84704	79573898
Dyspnoea	599.62	10.55	2148	83638	854877	78803725
Full blood count abnormal	376.33	10.55	327	85459	40147	79618455
Asthma-chronic obstructive pulmonary disease overlap syndrome	352.05	10.55	132	85654	3089	79655513
Productive cough	348.69	10.55	452	85334	87879	79570723
Cough	336.09	10.55	1010	84776	365779	79292823
Pneumonia	322.54	10.55	1483	84303	658763	78999839
Chest discomfort	258.67	10.55	502	85284	137542	79521060
Appendicolith	258.66	10.55	143	85643	8408	79650194
Sputum discoloured	248.49	10.55	198	85588	21545	79637057
Bronchiectasis	237.10	10.55	195	85591	22191	79636411
Completed suicide	225.35	10.55	9	85777	245758	79412844
Sleep disorder due to a general medical condition	209.59	10.55	151	85635	14126	79644476
Middle insomnia	193.66	10.55	151	85635	15918	79642684
Toxicity to various agents	169.33	10.55	124	85662	421416	79237186
Nasal congestion	166.59	10.55	297	85489	76255	79582347
Appendicitis	163.65	10.55	153	85633	20641	79637961
Forced expiratory volume decreased	141.40	10.55	94	85692	7720	79650882
Synovitis	130.22	10.55	8	85778	150726	79507876
Dyspnoea exertional	128.24	10.55	287	85499	86786	79571816
Respiratory failure	124.73	10.55	453	85333	180458	79478144
Lower respiratory tract infection	121.86	10.55	360	85426	128860	79529742
Nasal obstruction	121.27	10.55	55	85731	2109	79656493
Bronchitis	120.38	10.55	361	85425	130283	79528319
Stress	120.16	10.55	265	85521	79347	79579255
Cardiogenic shock	118.55	10.55	183	85603	41731	79616871
Drug abuse	116.22	10.55	18	85768	162673	79495929
Pulmonary function test decreased	114.90	10.55	82	85704	7555	79651047
Breath sounds abnormal	113.25	10.55	111	85675	15873	79642729
Therapeutic product effect incomplete	112.68	10.55	372	85414	141273	79517329
Total lung capacity increased	111.94	10.55	53	85733	2245	79656357
Alopecia	108.08	10.55	57	85729	231298	79427304
Eosinophilia	107.84	10.55	183	85603	45162	79613440
Toxic epidermal necrolysis	104.81	10.55	179	85607	44402	79614200
Drug intolerance	104.26	10.55	79	85707	264040	79394562
Systemic lupus erythematosus	100.09	10.55	8	85778	121141	79537461
Nasal polyps	99.63	10.55	74	85712	7253	79651349
Treatment failure	97.43	10.55	31	85755	170455	79488147
Oxygen saturation decreased	97.40	10.55	333	85453	128714	79529888
Ventricular fibrillation	96.82	10.55	144	85642	31782	79626820
Upper-airway cough syndrome	95.80	10.55	88	85698	11605	79646997
Hand deformity	94.54	10.55	4	85782	103915	79554687
Infusion related reaction	93.27	10.55	67	85719	230170	79428432
Nasal turbinate hypertrophy	91.82	10.55	33	85753	682	79657920
Respiratory distress	91.21	10.55	197	85589	58142	79600460
Blood phosphorus increased	90.92	10.55	81	85705	10266	79648336
Arthropathy	89.80	10.55	39	85747	177072	79481530
Rales	89.42	10.55	109	85677	19892	79638710
Blood immunoglobulin E increased	88.13	10.55	63	85723	5819	79652783
Drug ineffective	88.06	10.55	743	85043	1080170	78578432
Cardiac murmur	87.12	10.55	96	85690	15728	79642874
Bronchial neoplasm	86.73	10.55	29	85757	479	79658123
Rheumatoid arthritis	86.64	10.55	59	85727	208411	79450191
Pericarditis	85.78	10.55	7	85779	104229	79554373
Off label use	85.38	10.55	599	85187	906616	78751986
Bronchospasm	82.47	10.55	117	85669	24742	79633860
Glossodynia	82.18	10.55	8	85778	103329	79555273
Sleep apnoea syndrome	81.22	10.55	143	85643	36335	79622267
Joint swelling	80.52	10.55	116	85670	288530	79370072
Blood test abnormal	79.96	10.55	97	85689	17613	79640989
Hypercapnia	78.62	10.55	70	85716	8865	79649737
Pemphigus	78.43	10.55	8	85778	99574	79559028
Gastrooesophageal reflux disease	77.77	10.55	268	85518	103978	79554624
Vocal cord dysfunction	77.54	10.55	28	85758	587	79658015
Tachypnoea	77.03	10.55	130	85656	31933	79626669
Respiratory disorder	76.55	10.55	157	85629	44699	79613903
Acute respiratory failure	76.42	10.55	186	85600	59355	79599247
Hypoxia	75.78	10.55	264	85522	102979	79555623
Hyper IgE syndrome	75.76	10.55	27	85759	544	79658058
Haemoptysis	74.09	10.55	177	85609	55822	79602780
Oesophageal spasm	73.44	10.55	46	85740	3410	79655192
Total lung capacity decreased	72.87	10.55	43	85743	2862	79655740
Therapeutic product effect decreased	72.71	10.55	43	85743	163820	79494782
Contraindicated product administered	71.82	10.55	40	85746	157498	79501104
Rhonchi	71.69	10.55	48	85738	3988	79654614
Arthralgia	71.05	10.55	345	85441	571458	79087144
Pain	70.96	10.55	455	85331	703347	78955255
Endometrial ablation	70.78	10.55	29	85757	864	79657738
Respiration abnormal	70.49	10.55	62	85724	7726	79650876
Ventricular failure	69.41	10.55	25	85761	520	79658082
Restrictive pulmonary disease	69.29	10.55	40	85746	2555	79656047
Multiple organ dysfunction syndrome	68.05	10.55	283	85503	119963	79538639
Bronchopulmonary aspergillosis allergic	63.19	10.55	40	85746	3021	79655581
Bronchial haemorrhage	62.94	10.55	30	85756	1290	79657312
Rash	61.83	10.55	367	85419	577991	79080611
Emphysema	60.51	10.55	81	85705	16219	79642383
Rhinitis allergic	60.01	10.55	70	85716	12199	79646403
Upper respiratory tract infection	59.17	10.55	224	85562	90944	79567658
Heart sounds	58.75	10.55	26	85760	940	79657662
Prolonged expiration	57.91	10.55	28	85758	1243	79657359
Oesophageal pain	57.69	10.55	43	85743	4236	79654366
Diarrhoea	57.64	10.55	638	85148	879851	78778751
Lung hyperinflation	55.97	10.55	31	85755	1828	79656774
Rib deformity	54.87	10.55	17	85769	217	79658385
Helicobacter infection	53.86	10.55	6	85780	69698	79588904
Breast conserving surgery	53.71	10.55	23	85763	767	79657835
Duodenal ulcer perforation	52.97	10.55	5	85781	66206	79592396
Mycobacterium avium complex infection	52.78	10.55	42	85744	4558	79654044
Laryngeal stenosis	52.71	10.55	25	85761	1063	79657539
Pulmonary function test abnormal	52.23	10.55	40	85746	4104	79654498
Wound	52.23	10.55	30	85756	116149	79542453
Abdominal discomfort	51.86	10.55	121	85665	250606	79407996
Maternal exposure during pregnancy	51.12	10.55	43	85743	136495	79522107
Respiratory rate increased	51.12	10.55	87	85699	21513	79637089
Lung opacity	50.49	10.55	43	85743	5131	79653471
Sarcoidosis	50.15	10.55	53	85733	8282	79650320
Bronchial disorder	50.07	10.55	32	85754	2457	79656145
Blister	49.37	10.55	34	85752	119442	79539160
Rhinitis	48.10	10.55	69	85717	14738	79643864
Product use issue	46.89	10.55	97	85689	209725	79448877
Ascites	46.04	10.55	182	85604	75380	79583222
Hypoventilation	45.37	10.55	47	85739	7177	79651425
Loss of personal independence in daily activities	45.01	10.55	224	85562	102356	79556246
Pneumonitis	44.10	10.55	155	85631	60705	79597897
Intentional overdose	43.98	10.55	30	85756	105930	79552672
Throat clearing	43.42	10.55	30	85756	2624	79655978
Influenza	42.79	10.55	262	85524	129344	79529258
Sinus pain	42.58	10.55	34	85752	3708	79654894
Lung consolidation	42.02	10.55	50	85736	8897	79649705
Status asthmaticus	41.81	10.55	21	85765	1013	79657589
Reversible airways obstruction	41.37	10.55	27	85759	2149	79656453
Febrile neutropenia	41.24	10.55	120	85666	230879	79427723
Myasthenia gravis	40.64	10.55	53	85733	10346	79648256
Respiratory tract infection	40.59	10.55	130	85656	48559	79610043
Infective pulmonary exacerbation of cystic fibrosis	40.45	10.55	59	85727	12792	79645810
PCO2 increased	40.39	10.55	25	85761	1815	79656787
Hepatic enzyme increased	40.31	10.55	85	85701	182525	79476077
Bronchial hyperreactivity	39.76	10.55	30	85756	3010	79655592
Respiratory acidosis	39.06	10.55	54	85732	11146	79647456
Psoriatic arthropathy	38.23	10.55	18	85768	77981	79580621
Hyponatraemia	38.10	10.55	324	85462	177524	79481078
Muscle injury	37.98	10.55	4	85782	48557	79610045
Abdominal distension	37.69	10.55	239	85547	119411	79539191
Sinus disorder	37.58	10.55	78	85708	22386	79636216
Seasonal allergy	37.40	10.55	65	85721	16341	79642261
Lung neoplasm malignant	36.92	10.55	88	85698	27704	79630898
Lung disorder	36.83	10.55	178	85608	80379	79578223
Oedema peripheral	36.70	10.55	424	85362	251864	79406738
COVID-19 treatment	36.36	10.55	15	85771	455	79658147
Dysphonia	36.29	10.55	139	85647	56733	79601869
Sight disability	36.12	10.55	11	85775	132	79658470
Irritable bowel syndrome	36.11	10.55	11	85775	62230	79596372
PO2 decreased	36.03	10.55	28	85758	2935	79655667
Pulmonary mass	35.45	10.55	89	85697	28945	79629657
Red blood cell sedimentation rate increased	35.38	10.55	4	85782	45938	79612664
Neuropathy peripheral	35.36	10.55	61	85725	141244	79517358
Overdose	34.87	10.55	93	85693	184113	79474489
Impaired healing	34.83	10.55	26	85760	87629	79570973
Blood uric acid increased	34.55	10.55	56	85730	13304	79645298
Painful respiration	34.31	10.55	29	85757	3424	79655178
Intentional product use issue	34.25	10.55	70	85716	152042	79506560
Exposure during pregnancy	34.13	10.55	35	85751	101097	79557505
Polycystic ovaries	34.03	10.55	30	85756	3749	79654853
Diaphragmatic disorder	33.97	10.55	22	85764	1728	79656874
Aspiration	33.73	10.55	70	85716	20088	79638514
Analgesic therapy	33.64	10.55	18	85768	991	79657611
Thermohypoaesthesia	33.47	10.55	10	85776	112	79658490
Drug therapy	33.37	10.55	19	85767	1182	79657420
Chest injury	32.89	10.55	26	85760	2795	79655807
Drug-induced liver injury	32.80	10.55	15	85771	66102	79592500
Influenza B virus test positive	32.32	10.55	13	85773	369	79658233
Sinus tachycardia	31.18	10.55	99	85687	36809	79621793
Peak expiratory flow rate decreased	30.98	10.55	15	85771	668	79657934
Fatigue	30.71	10.55	764	85022	928963	78729639
Lymphoedema	30.70	10.55	51	85735	12362	79646240
Cyanosis	30.54	10.55	77	85709	25105	79633497
Airway peak pressure increased	30.05	10.55	12	85774	334	79658268
Discomfort	29.84	10.55	56	85730	125561	79533041
Sneezing	29.09	10.55	65	85721	19618	79638984
Swelling	29.06	10.55	127	85659	216584	79442018
Hyperphosphataemia	28.91	10.55	35	85751	6341	79652261
Hypomania	28.79	10.55	38	85748	7506	79651096
White blood cell count decreased	27.97	10.55	106	85680	188182	79470420
Sleep disorder therapy	27.92	10.55	16	85770	1008	79657594
Respiratory gas exchange disorder	27.86	10.55	15	85771	836	79657766
Hip arthroplasty	27.82	10.55	3	85783	35753	79622849
Kyphosis	27.57	10.55	23	85763	2668	79655934
Heart rate increased	27.48	10.55	223	85563	120501	79538101
Frustration tolerance decreased	27.42	10.55	37	85749	7465	79651137
Drug resistance	27.28	10.55	6	85780	42207	79616395
Cardiac failure congestive	27.18	10.55	253	85533	142149	79516453
Aortic aneurysm	26.91	10.55	39	85747	8407	79650195
Gastrointestinal disorder	26.86	10.55	57	85729	122148	79536454
Disease progression	26.60	10.55	105	85681	184257	79474345
Venous pressure jugular increased	26.39	10.55	17	85769	1323	79657279
Atrial fibrillation	26.32	10.55	327	85459	197559	79461043
Platelet count decreased	26.14	10.55	114	85672	194550	79464052
Hyperkaliuria	25.84	10.55	9	85777	169	79658433
Liver disorder	25.66	10.55	24	85762	72393	79586209
C-reactive protein abnormal	25.55	10.55	10	85776	48357	79610245
Pulmonary hypertension	25.51	10.55	111	85675	47969	79610633
Chronic respiratory failure	25.25	10.55	23	85763	2999	79655603
General physical health deterioration	25.16	10.55	426	85360	274812	79383790
Constipation	24.76	10.55	435	85351	282615	79375987
Wolff-Parkinson-White syndrome	24.56	10.55	10	85776	293	79658309
Pneumonia viral	24.52	10.55	39	85747	9119	79649483
Asthmatic crisis	24.49	10.55	19	85767	1987	79656615
Separation anxiety disorder	24.30	10.55	6	85780	30	79658572
Lactose intolerance	24.05	10.55	20	85766	2310	79656292
Psoriasis	23.97	10.55	37	85749	89550	79569052
Sensitivity to weather change	23.97	10.55	36	85750	8011	79650591
Multiple sclerosis relapse	23.96	10.55	10	85776	46523	79612079
Headache	23.54	10.55	530	85256	653242	79005360
Jaundice cholestatic	23.53	10.55	43	85743	11241	79647361
FEV1/FVC ratio decreased	23.52	10.55	9	85777	223	79658379
Suicide attempt	23.41	10.55	33	85753	82899	79575703
Respiratory tract congestion	23.15	10.55	60	85726	19894	79638708
Granuloma	23.14	10.55	36	85750	8261	79650341
Affective disorder	23.06	10.55	36	85750	8283	79650319
C-reactive protein increased	23.03	10.55	67	85719	128960	79529642
Genital herpes simplex	22.31	10.55	10	85776	373	79658229
Type IIa hyperlipidaemia	22.23	10.55	9	85777	260	79658342
Neutropenia	21.81	10.55	201	85585	287509	79371093
Sputum purulent	21.49	10.55	15	85771	1334	79657268
Eosinophil count increased	21.48	10.55	53	85733	17052	79641550
Peripheral swelling	21.47	10.55	186	85600	269431	79389171
Dyslipidaemia	21.37	10.55	42	85744	11591	79647011
Malignant neoplasm progression	21.21	10.55	75	85711	135915	79522687
Palmar-plantar erythrodysaesthesia syndrome	20.83	10.55	5	85781	33129	79625473
Injection site bruising	20.81	10.55	9	85777	40993	79617609
Hypoaesthesia	20.61	10.55	111	85675	179241	79479361
Drug ineffective for unapproved indication	20.61	10.55	15	85771	51223	79607379
Sepsis	20.41	10.55	405	85381	269023	79389579
Inflammation	20.38	10.55	44	85742	93709	79564893
Myelosuppression	20.21	10.55	9	85777	40287	79618315
Adverse event	20.13	10.55	21	85765	60193	79598409
Osteopenia	20.06	10.55	54	85732	18310	79640292
Decreased appetite	20.02	10.55	254	85532	342164	79316438
Blood pH decreased	19.97	10.55	25	85761	4686	79653916
Eye disorder	19.96	10.55	63	85723	23349	79635253
Hepatic function abnormal	19.75	10.55	30	85756	73077	79585525
Dust allergy	19.74	10.55	15	85771	1521	79657081
Blood calcium increased	19.66	10.55	38	85748	10362	79648240
Use of accessory respiratory muscles	19.27	10.55	10	85776	517	79658085
Cytomegalovirus infection	19.17	10.55	11	85775	42633	79615969
Iron deficiency	19.01	10.55	38	85748	10616	79647986
Obstruction	18.80	10.55	24	85762	4586	79654016
Bronchospasm paradoxical	18.70	10.55	7	85779	163	79658439
Injection site pain	18.69	10.55	74	85712	129764	79528838
Colitis ischaemic	18.66	10.55	47	85739	15312	79643290
Musculoskeletal stiffness	18.66	10.55	111	85675	174897	79483705
Humidity intolerance	18.65	10.55	9	85777	398	79658204
Oral candidiasis	18.56	10.55	72	85714	29556	79629046
Injection site erythema	18.44	10.55	35	85751	78162	79580440
Cor pulmonale	18.44	10.55	17	85769	2251	79656351
Injection site reaction	18.44	10.55	19	85767	54766	79603836
Ischaemic cardiomyopathy	18.21	10.55	31	85755	7664	79650938
Suicidal ideation	18.15	10.55	34	85752	76306	79582296
Bundle branch block left	18.13	10.55	39	85747	11474	79647128
Rhinorrhoea	18.11	10.55	142	85644	75932	79582670
Hypohidrosis	18.08	10.55	8	85778	289	79658313
Forced vital capacity decreased	18.07	10.55	15	85771	1728	79656874
Mobility decreased	17.99	10.55	69	85717	122106	79536496
Peak expiratory flow rate abnormal	17.89	10.55	6	85780	100	79658502
Stomatitis	17.89	10.55	89	85697	146668	79511934
Heparin-induced thrombocytopenia	17.84	10.55	35	85751	9647	79648955
Pneumonia staphylococcal	17.75	10.55	24	85762	4850	79653752
Basal cell carcinoma	17.74	10.55	9	85777	37366	79621236
Pancytopenia	17.73	10.55	105	85681	165640	79492962
Subcutaneous emphysema	17.69	10.55	15	85771	1779	79656823
Sopor	17.15	10.55	7	85779	33003	79625599
Rectal prolapse	17.08	10.55	16	85770	2162	79656440
Knee arthroplasty	16.96	10.55	13	85773	43235	79615367
Viral myelitis	16.92	10.55	6	85780	119	79658483
Bilirubin conjugated abnormal	16.88	10.55	6	85780	120	79658482
Long QT syndrome	16.83	10.55	26	85760	5929	79652673
Myocardial infarction	16.81	10.55	285	85501	183844	79474758
Appetite disorder	16.79	10.55	30	85756	7709	79650893
Depressive symptom	16.71	10.55	27	85759	6396	79652206
Carbon dioxide increased	16.70	10.55	16	85770	2224	79656378
Tachycardia	16.54	10.55	276	85510	177492	79481110
Total lung capacity abnormal	16.47	10.55	7	85779	229	79658373
Chest X-ray abnormal	16.39	10.55	30	85756	7853	79650749
Sedation	16.36	10.55	19	85767	51876	79606726
Tracheomalacia	16.32	10.55	8	85778	366	79658236
Dystrophic calcification	16.30	10.55	6	85780	133	79658469
Injection site swelling	16.26	10.55	16	85770	47116	79611486
Bronchial wall thickening	16.26	10.55	17	85769	2624	79655978
Generalised tonic-clonic seizure	16.22	10.55	14	85772	43896	79614706
Multimorbidity	16.21	10.55	13	85773	1426	79657176
Brain hypoxia	16.03	10.55	11	85775	952	79657650
Eosinophil count abnormal	15.97	10.55	10	85776	741	79657861
Dry eye	15.94	10.55	10	85776	36921	79621681
Sinusitis	15.86	10.55	297	85489	195204	79463398
Malaise	15.86	10.55	661	85125	489208	79169394
Premature delivery	15.86	10.55	3	85783	23464	79635138
Frequent bowel movements	15.78	10.55	6	85780	29533	79629069
Upper respiratory tract irritation	15.74	10.55	7	85779	256	79658346
Pneumonia pseudomonal	15.59	10.55	25	85761	5886	79652716
Arthritis	15.58	10.55	67	85719	114813	79543789
Occupational exposure to air contaminants	15.34	10.55	6	85780	158	79658444
Nausea	15.18	10.55	859	84927	956337	78702265
Extrapyramidal disorder	15.11	10.55	3	85783	22676	79635926
Drug eruption	15.05	10.55	15	85771	43920	79614682
Haematoma	15.05	10.55	102	85684	52093	79606509
Throat irritation	14.93	10.55	85	85701	40861	79617741
Bone marrow failure	14.76	10.55	20	85766	51087	79607515
Eye pruritus	14.56	10.55	52	85734	20518	79638084
Pupillary reflex impaired	14.54	10.55	18	85768	3335	79655267
Lactic acidosis	14.43	10.55	127	85659	70232	79588370
Toxic optic neuropathy	14.25	10.55	11	85775	1142	79657460
Abortion spontaneous	14.16	10.55	7	85779	29500	79629102
Dysgeusia	14.01	10.55	25	85761	57152	79601450
Oral herpes	13.98	10.55	6	85780	27448	79631154
Type 2 diabetes mellitus	13.81	10.55	107	85679	57015	79601587
Loss of consciousness	13.74	10.55	115	85671	167828	79490774
Liver injury	13.65	10.55	25	85761	56589	79602013
Inappropriate schedule of product administration	13.59	10.55	86	85700	133542	79525060
Supraventricular tachycardia	13.57	10.55	52	85734	21218	79637384
Illness	13.48	10.55	91	85695	46420	79612182
Chest pain	13.38	10.55	398	85388	281906	79376696
Pneumothorax	13.24	10.55	63	85723	28260	79630342
Pneumonia respiratory syncytial viral	13.15	10.55	13	85773	1877	79656725
Photophobia	13.10	10.55	3	85783	20525	79638077
Myalgia	13.08	10.55	132	85654	185509	79473093
Vascular parkinsonism	13.06	10.55	5	85781	124	79658478
Neuromyelitis optica spectrum disorder	13.01	10.55	10	85776	1032	79657570
Pulmonary embolism	12.98	10.55	258	85528	171396	79487206
Cytopenia	12.96	10.55	3	85783	20380	79638222
Underdose	12.95	10.55	10	85776	33141	79625461
Chronic sinusitis	12.94	10.55	37	85749	12989	79645613
Colitis ulcerative	12.92	10.55	11	85775	34731	79623871
Tracheitis	12.88	10.55	11	85775	1317	79657285
Injection site pruritus	12.77	10.55	16	85770	42267	79616335
Bursitis	12.56	10.55	12	85774	35832	79622770
Forced expiratory volume increased	12.44	10.55	4	85782	58	79658544
Grip strength decreased	12.44	10.55	4	85782	21865	79636737
Respiratory alkalosis	12.43	10.55	19	85767	4292	79654310
Haemophagocytic lymphohistiocytosis	12.41	10.55	4	85782	21833	79636769
Intentional self-injury	12.39	10.55	10	85776	32409	79626193
Stress cardiomyopathy	12.36	10.55	33	85753	11133	79647469
Leukopenia	12.36	10.55	74	85712	116439	79542163
Infantile haemangioma	12.32	10.55	3	85783	14	79658588
Drug hypersensitivity	12.29	10.55	237	85549	298679	79359923
Mucosal inflammation	12.25	10.55	41	85745	75539	79583063
Skin lesion	12.20	10.55	82	85704	41762	79616840
Infective exacerbation of chronic obstructive airways disease	12.16	10.55	15	85771	2769	79655833
Tongue exfoliation	12.14	10.55	5	85781	151	79658451
Pneumonia haemophilus	11.97	10.55	10	85776	1162	79657440
Bronchitis viral	11.89	10.55	10	85776	1173	79657429
Amaurosis	11.83	10.55	10	85776	1181	79657421
Coronary artery disease	11.83	10.55	115	85671	65359	79593243
Joint stiffness	11.77	10.55	16	85770	40814	79617788
Schizophrenia	11.77	10.55	40	85746	15400	79643202
Metastases to liver	11.77	10.55	8	85778	28306	79630296
Paraesthesia	11.76	10.55	127	85659	176196	79482406
Vital capacity decreased	11.74	10.55	12	85774	1804	79656798
Nephrocalcinosis	11.72	10.55	11	85775	1491	79657111
Product use in unapproved indication	11.72	10.55	194	85592	250165	79408437
Interstitial lung disease	11.69	10.55	72	85714	112528	79546074
Glycosylated haemoglobin decreased	11.64	10.55	8	85778	694	79657908
Cardiac disorder	11.63	10.55	115	85671	65642	79592960
Hyperlipidaemia	11.45	10.55	57	85729	26036	79632566
Neutrophil count decreased	11.44	10.55	57	85729	93902	79564700
Tracheal disorder	11.39	10.55	7	85779	502	79658100
Oropharyngeal pain	11.38	10.55	173	85613	109180	79549422
Pleural thickening	11.35	10.55	15	85771	2967	79655635
Diastolic hypotension	11.34	10.55	5	85781	179	79658423
Idiopathic pulmonary fibrosis	11.31	10.55	18	85768	4210	79654392
Hyperlactacidaemia	11.26	10.55	21	85765	5574	79653028
Pharyngeal mass	11.18	10.55	6	85780	332	79658270
Blood bicarbonate decreased	11.10	10.55	20	85766	5171	79653431
Injection related reaction	10.91	10.55	9	85777	1027	79657575
Expiratory reserve volume decreased	10.85	10.55	4	85782	89	79658513
Tumour hyperprogression	10.80	10.55	5	85781	201	79658401
Myelodysplastic syndrome	10.78	10.55	10	85776	30291	79628311
Serotonin syndrome	10.75	10.55	20	85766	45007	79613595
Oesophageal motility disorder	10.68	10.55	7	85779	561	79658041
Dry mouth	10.66	10.55	143	85643	87876	79570726
Pancreatitis	10.57	10.55	38	85748	68537	79590065
Hyperglycaemia	10.56	10.55	119	85667	70216	79588386

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R01AX03	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Other nasal preparations
ATC	R03AL01	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC	R03AL02	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC	R03BB01	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Anticholinergics
FDA MoA	N0000175370	Cholinergic Antagonists
FDA EPC	N0000175574	Anticholinergic
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D018678	Cholinergic Agents
MeSH PA	D018680	Cholinergic Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents
CHEBI has role	CHEBI:35523	bronchodilator
CHEBI has role	CHEBI:48876	muscarinic antagonists
CHEBI has role	CHEBI:53784	antispasmodics

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Bronchospasm	indication	4386001
Chronic obstructive lung disease	indication	13645005	DOID:3083
Bronchitis	indication	32398004	DOID:6132
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Pulmonary emphysema	indication	87433001
Chronic Obstructive Pulmonary Disease with Bronchospasms	indication
Asthma	off-label use	195967001	DOID:2841
Asthma-chronic obstructive pulmonary disease overlap syndrome	off-label use	10692761000119107
Ocular hypertension	contraindication	4210003	DOID:9282
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypokalemia	contraindication	43339004
Conduction disorder of the heart	contraindication	44808001
Ketoacidosis	contraindication	56051008
Metabolic acidosis	contraindication	59455009
Diabetes mellitus	contraindication	73211009	DOID:9351
Paradoxical bronchospasm	contraindication	102578005
Prolonged QT interval	contraindication	111975006
Seizure disorder	contraindication	128613002
Bladder outflow obstruction	contraindication	236645006
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Chronic myocardial ischemia	contraindication	413844008	DOID:3393
Myocardial ischemia	contraindication	414795007	DOID:3393
Congenital long QT syndrome	contraindication	442917000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.24	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN	ANTAGONIST	Ki	9.29		WOMBAT-PK	CHEMBL
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	8.82		WOMBAT-PK
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	9.18		WOMBAT-PK
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	8.77		WOMBAT-PK
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	9.31		WOMBAT-PK
Solute carrier family 22 member 2	Transporter	O15244	S22A2_HUMAN		IC50	4.82		WOMBAT-PK
Muscarinic acetylcholine receptor M2	GPCR		ACM2_RAT		Ki	9.11		CHEMBL
Muscarinic acetylcholine receptor M1	GPCR		ACM1_RAT		Ki	9.54		CHEMBL
Muscarinic acetylcholine receptor M3	GPCR		ACM3_RAT		Ki	9.74		CHEMBL

External reference:

ID	Source
4019791	VUID
N0000147880	NUI
D02212	KEGG_DRUG
66985-17-9	SECONDARY_CAS_RN
4019341	VANDF
4019791	VANDF
C0027235	UMLSCUI
CHEBI:5956	CHEBI
X8M	PDB_CHEM_ID
CHEMBL1621597	ChEMBL_ID
DB00332	DRUGBANK_ID
CHEMBL1464005	ChEMBL_ID
CHEMBL2134724	ChEMBL_ID
D009241	MESH_DESCRIPTOR_UI
3746	PUBCHEM_CID
325	IUPHAR_LIGAND_ID
GR88G0I6UL	UNII
1309404	RXNORM
4916	MMSL
6256	MMSL
d00265	MMSL
001750	NDDF
004943	NDDF
108624006	SNOMEDCT_US
372518007	SNOMEDCT_US
386881005	SNOMEDCT_US
725862005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0045	SPRAY	21 ug	NASAL	ANDA	3 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0045	SPRAY	21 ug	NASAL	ANDA	3 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0046	SPRAY	42 ug	NASAL	ANDA	16 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0046	SPRAY	42 ug	NASAL	ANDA	16 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-7970	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	22 sections
Ipratropium Bromide and Albuterol Sulfate	HUMAN PRESCRIPTION DRUG LABEL	2	0378-9671	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	28 sections
Ipratropium Bromide and Albuterol Sulfate	HUMAN PRESCRIPTION DRUG LABEL	2	0487-0201	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	28 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	0487-9801	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	22 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3798	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	20 sections
Combivent Respimat	HUMAN PRESCRIPTION DRUG LABEL	2	0597-0024	SPRAY, METERED	20 ug	RESPIRATORY (INHALATION)	NDA	27 sections
Combivent Respimat	HUMAN PRESCRIPTION DRUG LABEL	2	0597-0024	SPRAY, METERED	20 ug	RESPIRATORY (INHALATION)	NDA	27 sections
Atrovent HFA	HUMAN PRESCRIPTION DRUG LABEL	1	0597-0087	AEROSOL, METERED	17 ug	RESPIRATORY (INHALATION)	NDA	29 sections
Atrovent HFA	HUMAN PRESCRIPTION DRUG LABEL	1	0597-0087	AEROSOL, METERED	17 ug	RESPIRATORY (INHALATION)	NDA	29 sections
Ipratropium Bromide and Albuterol Sulfate	HUMAN PRESCRIPTION DRUG LABEL	2	0781-7146	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	28 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	0781-7157	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	23 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	16714-526	SPRAY, METERED	21 ug	NASAL	ANDA	24 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	16714-527	SPRAY, METERED	42 ug	NASAL	ANDA	25 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	21695-911	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	21 sections
Ipratropium bromide	HUMAN PRESCRIPTION DRUG LABEL	1	24208-398	SPRAY, METERED	21 ug	NASAL	ANDA	27 sections
Ipratropium bromide	HUMAN PRESCRIPTION DRUG LABEL	1	24208-398	SPRAY, METERED	21 ug	NASAL	ANDA	27 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	24208-399	SPRAY, METERED	42 ug	NASAL	ANDA	25 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	24208-399	SPRAY, METERED	42 ug	NASAL	ANDA	25 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	42254-041	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	19 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	42254-355	SPRAY, METERED	42 ug	NASAL	ANDA	25 sections
Ipratropium Bromide	Human Prescription Drug Label	1	47335-706	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	19 sections
Ipratropium Bromide	Human Prescription Drug Label	1	47335-706	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	19 sections
Ipratropium Bromide and Albuterol Sulfate	Human Prescription Drug Label	2	47335-756	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	22 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0668	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	21 sections
Ipratropium Bromide	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0668	SOLUTION	0.50 mg	RESPIRATORY (INHALATION)	ANDA	21 sections
AtroventHFA	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0961	AEROSOL, METERED	17 ug	RESPIRATORY (INHALATION)	NDA	25 sections