euflavine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
acridine derivatives 4317 69235-50-3

Description:

MoleculeDescription

Synonyms:

  • acriflavinium chloride
  • acriflavine chloride
  • acriflavine
  • euflavine
3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication.
  • Molecular weight: 468.99
  • Formula: C27H25ClN6
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 55.92
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AA03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Acridine derivatives
ATC R02AA13 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D004396 Coloring Agents
MeSH PA D005456 Fluorescent Dyes
MeSH PA D007202 Indicators and Reagents
MeSH PA D007364 Intercalating Agents
MeSH PA D049408 Luminescent Agents
CHEBI has role CHEBI:24853 intercalator
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:48218 antiseptic drug
CHEBI has role CHEBI:50903 carcinogenic agent

Related Drugs by ATC class:

D08AA Acridine derivatives 2 drugs
aminoacridineethacridine
R02AA Antiseptics 15 drugs
ambazonebenzalkoniumbenzethoniumcetrimoniumcetylpyridiniumchlorhexidinechlorquinaldoldequaliniumdichlorobenzyl alcoholhexamidinehexylresorcinoloctenidine show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Hypoxia-inducible factor 1-alpha Transcription factor IC50 6 CHEMBL
ORF 73 Nuclear other AC50 6.38 CHEMBL
Replicase polyprotein 1ab Enzyme IC50 5.25 CHEMBL

External reference:

IDSource
4020812 VUID
N0000148332 NUI
65589-70-0 SECONDARY_CAS_RN
4020580 VANDF
4020812 VANDF
CHEMBL354349 ChEMBL_ID
CHEMBL5219995 ChEMBL_ID
CHEMBL5219994 ChEMBL_ID
C000718540 MESH_SUPPLEMENTAL_RECORD_UI
DB13326 DRUGBANK_ID
DB13373 DRUGBANK_ID
1664337 RXNORM
NOCODE MMSL
002613 NDDF
412535007 SNOMEDCT_US
412537004 SNOMEDCT_US
C0001187 UMLSCUI
D000167 MESH_DESCRIPTOR_UI
CHEBI:74729 CHEBI
443101 PUBCHEM_CID
1T3A50395T UNII
1T3A50395T INXIGHT DRUGS

Pharmaceutical products:

None