| Stem definition | Drug id | CAS RN |
|---|---|---|
| aminoglycosides, antibiotics obtained from various Micromonospora | 4265 | 1405-41-0 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
|
| Dose | Unit | Route |
|---|---|---|
| 0.24 | g | P |
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.28 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 0.33 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.70 hours | Lombardo F, Berellini G, Obach RS |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 19, 1970 | FDA | SCHERING |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Acute kidney injury | 623.66 | 14.65 | 576 | 19644 | 262839 | 63205963 |
| Premature delivery | 404.82 | 14.65 | 196 | 20024 | 30085 | 63438717 |
| Normal labour | 396.69 | 14.65 | 77 | 20143 | 440 | 63468362 |
| Delivery | 335.61 | 14.65 | 80 | 20140 | 1323 | 63467479 |
| Drug reaction with eosinophilia and systemic symptoms | 248.36 | 14.65 | 147 | 20073 | 33689 | 63435113 |
| Renal tubular necrosis | 199.21 | 14.65 | 90 | 20130 | 11788 | 63457014 |
| Multiple organ dysfunction syndrome | 190.19 | 14.65 | 152 | 20068 | 56600 | 63412202 |
| Toxic epidermal necrolysis | 157.48 | 14.65 | 99 | 20121 | 25235 | 63443567 |
| Pathogen resistance | 131.67 | 14.65 | 56 | 20164 | 6342 | 63462460 |
| Septic shock | 118.16 | 14.65 | 125 | 20095 | 66504 | 63402298 |
| Maternal exposure during pregnancy | 115.24 | 14.65 | 231 | 19989 | 219831 | 63248971 |
| Peritonitis bacterial | 114.85 | 14.65 | 47 | 20173 | 4832 | 63463970 |
| Renal failure | 111.57 | 14.65 | 161 | 20059 | 117491 | 63351311 |
| Sepsis | 104.26 | 14.65 | 180 | 20040 | 152943 | 63315859 |
| Ototoxicity | 89.14 | 14.65 | 28 | 20192 | 1334 | 63467468 |
| Bartter's syndrome | 83.19 | 14.65 | 13 | 20207 | 12 | 63468790 |
| Peritonitis | 82.20 | 14.65 | 57 | 20163 | 17097 | 63451705 |
| Anaphylactic reaction | 80.17 | 14.65 | 102 | 20118 | 65998 | 63402804 |
| Abdominal discomfort | 79.41 | 14.65 | 6 | 20214 | 320879 | 63147923 |
| Eosinophilia | 78.41 | 14.65 | 62 | 20158 | 22694 | 63446108 |
| Product use in unapproved indication | 77.46 | 14.65 | 174 | 20046 | 178906 | 63289896 |
| Toxic skin eruption | 76.67 | 14.65 | 49 | 20171 | 12836 | 63455966 |
| Mucosal inflammation | 72.65 | 14.65 | 82 | 20138 | 46846 | 63421956 |
| Drug intolerance | 70.44 | 14.65 | 8 | 20212 | 308653 | 63160149 |
| Drug resistance | 69.55 | 14.65 | 58 | 20162 | 22875 | 63445927 |
| Nephropathy toxic | 69.01 | 14.65 | 41 | 20179 | 9438 | 63459364 |
| Antibiotic level above therapeutic | 67.46 | 14.65 | 17 | 20203 | 357 | 63468445 |
| Pyrexia | 67.33 | 14.65 | 312 | 19908 | 470166 | 62998636 |
| Joint swelling | 66.61 | 14.65 | 12 | 20208 | 327654 | 63141148 |
| Excessive eye blinking | 62.20 | 14.65 | 21 | 20199 | 1259 | 63467543 |
| Shock haemorrhagic | 59.79 | 14.65 | 38 | 20182 | 9857 | 63458945 |
| Rheumatoid arthritis | 56.85 | 14.65 | 7 | 20213 | 253812 | 63214990 |
| Systemic lupus erythematosus | 54.34 | 14.65 | 3 | 20217 | 208915 | 63259887 |
| Neutropenic sepsis | 52.82 | 14.65 | 43 | 20177 | 16395 | 63452407 |
| Premature baby | 51.88 | 14.65 | 47 | 20173 | 20688 | 63448114 |
| Stevens-Johnson syndrome | 51.81 | 14.65 | 51 | 20169 | 24899 | 63443903 |
| Nasopharyngitis | 50.19 | 14.65 | 10 | 20210 | 254247 | 63214555 |
| Tubulointerstitial nephritis | 49.58 | 14.65 | 45 | 20175 | 19858 | 63448944 |
| Oliguria | 47.77 | 14.65 | 32 | 20188 | 9069 | 63459733 |
| Endocarditis | 47.50 | 14.65 | 27 | 20193 | 5723 | 63463079 |
| Arthropathy | 46.83 | 14.65 | 9 | 20211 | 234783 | 63234019 |
| Headache | 46.24 | 14.65 | 82 | 20138 | 633159 | 62835643 |
| Fall | 45.61 | 14.65 | 35 | 20185 | 392299 | 63076503 |
| Vestibular disorder | 44.99 | 14.65 | 17 | 20203 | 1414 | 63467388 |
| Metabolic alkalosis | 44.45 | 14.65 | 21 | 20199 | 3040 | 63465762 |
| Oropharyngeal oedema | 44.30 | 14.65 | 12 | 20208 | 337 | 63468465 |
| Candida infection | 42.95 | 14.65 | 49 | 20171 | 28302 | 63440500 |
| Drug interaction | 42.80 | 14.65 | 165 | 20055 | 228966 | 63239836 |
| Intraventricular haemorrhage neonatal | 41.62 | 14.65 | 10 | 20210 | 171 | 63468631 |
| Linear IgA disease | 41.18 | 14.65 | 16 | 20204 | 1435 | 63467367 |
| Fatigue | 40.09 | 14.65 | 147 | 20073 | 887881 | 62580921 |
| Arthritis bacterial | 39.50 | 14.65 | 25 | 20195 | 6438 | 63462364 |
| Umbilical erythema | 38.02 | 14.65 | 8 | 20212 | 72 | 63468730 |
| Renal injury | 37.51 | 14.65 | 28 | 20192 | 9411 | 63459391 |
| Therapeutic product effect decreased | 37.28 | 14.65 | 8 | 20212 | 193179 | 63275623 |
| Pancytopenia | 37.26 | 14.65 | 90 | 20130 | 96843 | 63371959 |
| Foetal exposure during pregnancy | 36.66 | 14.65 | 48 | 20172 | 31914 | 63436888 |
| Abscess neck | 36.52 | 14.65 | 12 | 20208 | 661 | 63468141 |
| Anuria | 36.52 | 14.65 | 31 | 20189 | 12520 | 63456282 |
| Pain | 36.49 | 14.65 | 118 | 20102 | 740510 | 62728292 |
| Contraindicated product administered | 36.35 | 14.65 | 12 | 20208 | 217636 | 63251166 |
| Renal impairment | 36.08 | 14.65 | 84 | 20136 | 88271 | 63380531 |
| Mental status changes postoperative | 35.62 | 14.65 | 9 | 20211 | 191 | 63468611 |
| Enterococcal infection | 35.08 | 14.65 | 25 | 20195 | 7823 | 63460979 |
| Musculoskeletal stiffness | 34.90 | 14.65 | 8 | 20212 | 184610 | 63284192 |
| Hyperchlorhydria | 34.20 | 14.65 | 15 | 20205 | 1829 | 63466973 |
| Disseminated intravascular coagulation | 34.19 | 14.65 | 36 | 20184 | 19015 | 63449787 |
| Confusion postoperative | 33.78 | 14.65 | 9 | 20211 | 237 | 63468565 |
| Haemodynamic instability | 33.73 | 14.65 | 26 | 20194 | 9164 | 63459638 |
| Liver abscess | 33.70 | 14.65 | 17 | 20203 | 2837 | 63465965 |
| Noninfectious peritonitis | 33.45 | 14.65 | 8 | 20212 | 134 | 63468668 |
| Weight increased | 33.28 | 14.65 | 21 | 20199 | 260771 | 63208031 |
| Sepsis syndrome | 32.57 | 14.65 | 12 | 20208 | 930 | 63467872 |
| Escherichia infection | 32.08 | 14.65 | 29 | 20191 | 12725 | 63456077 |
| Cholestasis | 31.90 | 14.65 | 43 | 20177 | 29391 | 63439411 |
| Neutropenia | 31.82 | 14.65 | 125 | 20095 | 174880 | 63293922 |
| Tendon necrosis | 31.80 | 14.65 | 5 | 20215 | 5 | 63468797 |
| Renal tubular disorder | 31.74 | 14.65 | 16 | 20204 | 2666 | 63466136 |
| Skin test positive | 31.63 | 14.65 | 11 | 20209 | 721 | 63468081 |
| Acute respiratory distress syndrome | 31.21 | 14.65 | 38 | 20182 | 23496 | 63445306 |
| Product dose omission issue | 31.11 | 14.65 | 18 | 20202 | 234295 | 63234507 |
| Thrombocytopenia | 30.81 | 14.65 | 112 | 20108 | 151045 | 63317757 |
| Peripheral swelling | 30.52 | 14.65 | 24 | 20196 | 265918 | 63202884 |
| Deafness neurosensory | 30.22 | 14.65 | 19 | 20201 | 4836 | 63463966 |
| Folate deficiency | 29.98 | 14.65 | 15 | 20205 | 2460 | 63466342 |
| Crystalluria | 28.95 | 14.65 | 9 | 20211 | 414 | 63468388 |
| Discomfort | 28.35 | 14.65 | 9 | 20211 | 167365 | 63301437 |
| Arthralgia | 27.85 | 14.65 | 91 | 20129 | 569619 | 62899183 |
| Retinal infarction | 27.59 | 14.65 | 6 | 20214 | 64 | 63468738 |
| Blood creatinine increased | 26.99 | 14.65 | 75 | 20145 | 87769 | 63381033 |
| Procedural hypertension | 26.91 | 14.65 | 8 | 20212 | 316 | 63468486 |
| Therapeutic product effect incomplete | 26.67 | 14.65 | 4 | 20216 | 125052 | 63343750 |
| Rash erythematous | 26.32 | 14.65 | 48 | 20172 | 42462 | 63426340 |
| Guillain-Barre syndrome | 26.17 | 14.65 | 16 | 20204 | 3877 | 63464925 |
| Application site scab | 26.10 | 14.65 | 7 | 20213 | 189 | 63468613 |
| Necrotising enterocolitis neonatal | 25.46 | 14.65 | 7 | 20213 | 208 | 63468594 |
| Endocarditis bacterial | 25.27 | 14.65 | 9 | 20211 | 633 | 63468169 |
| Rash maculo-papular | 25.00 | 14.65 | 40 | 20180 | 31856 | 63436946 |
| Lemierre syndrome | 24.90 | 14.65 | 6 | 20214 | 104 | 63468698 |
| Morganella infection | 24.88 | 14.65 | 9 | 20211 | 662 | 63468140 |
| Lactic acidosis | 24.68 | 14.65 | 44 | 20176 | 38243 | 63430559 |
| Puerperal pyrexia | 24.63 | 14.65 | 5 | 20215 | 37 | 63468765 |
| Hypoglossal nerve paresis | 24.43 | 14.65 | 6 | 20214 | 113 | 63468689 |
| Blood phosphorus decreased | 24.20 | 14.65 | 16 | 20204 | 4437 | 63464365 |
| Toxic shock syndrome streptococcal | 24.04 | 14.65 | 6 | 20214 | 121 | 63468681 |
| Infusion related reaction | 23.63 | 14.65 | 26 | 20194 | 245495 | 63223307 |
| Device related infection | 23.58 | 14.65 | 33 | 20187 | 23359 | 63445443 |
| Neonatal respiratory failure | 23.32 | 14.65 | 7 | 20213 | 286 | 63468516 |
| Ejection fraction decreased | 23.25 | 14.65 | 32 | 20188 | 22300 | 63446502 |
| Vascular device infection | 23.22 | 14.65 | 19 | 20201 | 7293 | 63461509 |
| Peritoneal dialysis complication | 22.87 | 14.65 | 10 | 20210 | 1210 | 63467592 |
| Pericarditis | 22.41 | 14.65 | 7 | 20213 | 131572 | 63337230 |
| Pain in extremity | 22.29 | 14.65 | 45 | 20175 | 331441 | 63137361 |
| Injection site pain | 21.94 | 14.65 | 7 | 20213 | 129793 | 63339009 |
| Anaphylactic shock | 21.86 | 14.65 | 32 | 20188 | 23601 | 63445201 |
| Death neonatal | 21.61 | 14.65 | 9 | 20211 | 966 | 63467836 |
| Aspergillus infection | 21.54 | 14.65 | 19 | 20201 | 8074 | 63460728 |
| Purpura | 21.30 | 14.65 | 22 | 20198 | 11363 | 63457439 |
| Wound | 21.01 | 14.65 | 13 | 20207 | 163250 | 63305552 |
| Macroglossia | 20.81 | 14.65 | 8 | 20212 | 697 | 63468105 |
| Swelling | 20.62 | 14.65 | 35 | 20185 | 275343 | 63193459 |
| Hypopyon | 20.52 | 14.65 | 8 | 20212 | 724 | 63468078 |
| Brain abscess | 20.39 | 14.65 | 11 | 20209 | 2107 | 63466695 |
| Agranulocytosis | 20.36 | 14.65 | 32 | 20188 | 25102 | 63443700 |
| Inflammatory marker increased | 20.12 | 14.65 | 17 | 20203 | 6822 | 63461980 |
| Sepsis neonatal | 19.98 | 14.65 | 7 | 20213 | 469 | 63468333 |
| Hepatic enzyme increased | 19.94 | 14.65 | 21 | 20199 | 202307 | 63266495 |
| Kussmaul respiration | 19.92 | 14.65 | 6 | 20214 | 248 | 63468554 |
| Malaise | 19.91 | 14.65 | 67 | 20153 | 415887 | 63052915 |
| Drug level increased | 19.90 | 14.65 | 30 | 20190 | 22706 | 63446096 |
| Endophthalmitis | 19.74 | 14.65 | 13 | 20207 | 3579 | 63465223 |
| Immune reconstitution inflammatory syndrome | 19.72 | 14.65 | 16 | 20204 | 6068 | 63462734 |
| Nausea | 19.66 | 14.65 | 176 | 20044 | 854295 | 62614507 |
| Clostridial infection | 19.65 | 14.65 | 14 | 20206 | 4378 | 63464424 |
| Tachycardia | 19.55 | 14.65 | 82 | 20138 | 118074 | 63350728 |
| Psoriatic arthropathy | 19.34 | 14.65 | 3 | 20217 | 91517 | 63377285 |
| Gastrointestinal haemorrhage | 19.00 | 14.65 | 63 | 20157 | 81113 | 63387689 |
| Necrosis | 19 | 14.65 | 15 | 20205 | 5472 | 63463330 |
| Septic embolus | 18.95 | 14.65 | 8 | 20212 | 889 | 63467913 |
| Tonsillitis bacterial | 18.86 | 14.65 | 5 | 20215 | 129 | 63468673 |
| Neurotoxicity | 18.68 | 14.65 | 25 | 20195 | 16965 | 63451837 |
| Spinal subdural haematoma | 18.40 | 14.65 | 5 | 20215 | 142 | 63468660 |
| Anal ulcer | 18.39 | 14.65 | 7 | 20213 | 594 | 63468208 |
| Coagulation time prolonged | 18.20 | 14.65 | 9 | 20211 | 1439 | 63467363 |
| Acute generalised exanthematous pustulosis | 18.20 | 14.65 | 20 | 20200 | 11079 | 63457723 |
| Rash morbilliform | 18.19 | 14.65 | 12 | 20208 | 3313 | 63465489 |
| Hypoperfusion | 18.09 | 14.65 | 9 | 20211 | 1458 | 63467344 |
| Foetal heart rate decreased | 18.01 | 14.65 | 5 | 20215 | 154 | 63468648 |
| Haemolytic anaemia | 17.93 | 14.65 | 19 | 20201 | 10106 | 63458696 |
| Shock | 17.81 | 14.65 | 29 | 20191 | 23434 | 63445368 |
| Low birth weight baby | 17.52 | 14.65 | 16 | 20204 | 7113 | 63461689 |
| Musculoskeletal pain | 17.43 | 14.65 | 4 | 20216 | 92273 | 63376529 |
| Exfoliative rash | 17.36 | 14.65 | 11 | 20209 | 2836 | 63465966 |
| Gingival swelling | 17.32 | 14.65 | 13 | 20207 | 4405 | 63464397 |
| Urogenital disorder | 17.20 | 14.65 | 4 | 20216 | 59 | 63468743 |
| Human herpesvirus 6 infection | 16.98 | 14.65 | 11 | 20209 | 2946 | 63465856 |
| Dermatitis exfoliative | 16.95 | 14.65 | 14 | 20206 | 5445 | 63463357 |
| Umbilical cord around neck | 16.86 | 14.65 | 5 | 20215 | 196 | 63468606 |
| Infusion site necrosis | 16.78 | 14.65 | 4 | 20216 | 66 | 63468736 |
| Staphylococcal infection | 16.59 | 14.65 | 39 | 20181 | 41217 | 63427585 |
| Insomnia | 16.44 | 14.65 | 27 | 20193 | 215225 | 63253577 |
| Bacterial sepsis | 16.30 | 14.65 | 12 | 20208 | 3946 | 63464856 |
| Pseudo-Bartter syndrome | 16.30 | 14.65 | 4 | 20216 | 75 | 63468727 |
| Feeling abnormal | 16.26 | 14.65 | 14 | 20206 | 148378 | 63320424 |
| Geotrichum infection | 16.25 | 14.65 | 6 | 20214 | 468 | 63468334 |
| Haemodialysis | 16.22 | 14.65 | 17 | 20203 | 8930 | 63459872 |
| Petechiae | 16.13 | 14.65 | 21 | 20199 | 13876 | 63454926 |
| Toxic shock syndrome | 16.10 | 14.65 | 7 | 20213 | 835 | 63467967 |
| Drug eruption | 16.02 | 14.65 | 31 | 20189 | 28663 | 63440139 |
| Adverse drug reaction | 15.99 | 14.65 | 3 | 20217 | 79711 | 63389091 |
| Neonatal cardiac failure | 15.79 | 14.65 | 3 | 20217 | 15 | 63468787 |
| Staphylococcal sepsis | 15.74 | 14.65 | 16 | 20204 | 8112 | 63460690 |
| Candida test positive | 15.69 | 14.65 | 7 | 20213 | 889 | 63467913 |
| Asthenia | 15.61 | 14.65 | 66 | 20154 | 383538 | 63085264 |
| Product used for unknown indication | 15.57 | 14.65 | 6 | 20214 | 526 | 63468276 |
| Pancreatitis haemorrhagic | 15.56 | 14.65 | 6 | 20214 | 527 | 63468275 |
| Arthritis | 15.23 | 14.65 | 9 | 20211 | 115912 | 63352890 |
| Sudden visual loss | 15.19 | 14.65 | 3 | 20217 | 19 | 63468783 |
| Skin oedema | 15.13 | 14.65 | 7 | 20213 | 966 | 63467836 |
| Neonatal disorder | 15.04 | 14.65 | 6 | 20214 | 577 | 63468225 |
| Hypocalcaemia | 15.01 | 14.65 | 32 | 20188 | 31681 | 63437121 |
| Odynophagia | 14.98 | 14.65 | 15 | 20205 | 7471 | 63461331 |
| Bronchopulmonary aspergillosis | 14.93 | 14.65 | 16 | 20204 | 8619 | 63460183 |
| Corneal deposits | 14.92 | 14.65 | 5 | 20215 | 293 | 63468509 |
| Neuromuscular blockade | 14.92 | 14.65 | 5 | 20215 | 293 | 63468509 |
| Gait disturbance | 14.92 | 14.65 | 22 | 20198 | 183156 | 63285646 |
| Meconium in amniotic fluid | 14.90 | 14.65 | 5 | 20215 | 294 | 63468508 |
| Hydrops foetalis | 14.80 | 14.65 | 6 | 20214 | 602 | 63468200 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Acute kidney injury | 477.56 | 15.06 | 741 | 20542 | 304247 | 34631401 |
| Drug reaction with eosinophilia and systemic symptoms | 209.33 | 15.06 | 168 | 21115 | 32844 | 34902804 |
| Pathogen resistance | 202.69 | 15.06 | 104 | 21179 | 9378 | 34926270 |
| Renal tubular necrosis | 158.94 | 15.06 | 106 | 21177 | 15574 | 34920074 |
| Eosinophilia | 130.25 | 15.06 | 116 | 21167 | 26106 | 34909542 |
| Drug resistance | 91.44 | 15.06 | 95 | 21188 | 25832 | 34909816 |
| Endocarditis | 88.45 | 15.06 | 53 | 21230 | 6458 | 34929190 |
| Rash maculo-papular | 87.58 | 15.06 | 97 | 21186 | 28354 | 34907294 |
| Crystalluria | 86.48 | 15.06 | 25 | 21258 | 456 | 34935192 |
| Spinal muscular atrophy | 82.09 | 15.06 | 23 | 21260 | 373 | 34935275 |
| Delusion of grandeur | 75.76 | 15.06 | 28 | 21255 | 1132 | 34934516 |
| Pneumococcal sepsis | 72.63 | 15.06 | 27 | 21256 | 1110 | 34934538 |
| Ototoxicity | 71.85 | 15.06 | 31 | 21252 | 1886 | 34933762 |
| Tubulointerstitial nephritis | 70.49 | 15.06 | 75 | 21208 | 20949 | 34914699 |
| Nephropathy toxic | 69.15 | 15.06 | 59 | 21224 | 12529 | 34923119 |
| Multiple organ dysfunction syndrome | 67.53 | 15.06 | 146 | 21137 | 76420 | 34859228 |
| Pyrexia | 64.78 | 15.06 | 384 | 20899 | 332629 | 34603019 |
| Peritonitis bacterial | 61.15 | 15.06 | 41 | 21242 | 6069 | 34929579 |
| Anaphylactic reaction | 59.19 | 15.06 | 85 | 21198 | 32216 | 34903432 |
| Toxic skin eruption | 57.76 | 15.06 | 51 | 21232 | 11334 | 34924314 |
| Red blood cell hyperchromic morphology | 57.12 | 15.06 | 10 | 21273 | 10 | 34935638 |
| Septic shock | 56.63 | 15.06 | 131 | 21152 | 71703 | 34863945 |
| Rhinalgia | 56.44 | 15.06 | 22 | 21261 | 1031 | 34934617 |
| Increased bronchial secretion | 56.35 | 15.06 | 26 | 21257 | 1855 | 34933793 |
| Motor neurone disease | 55.16 | 15.06 | 18 | 21265 | 499 | 34935149 |
| Stoma closure | 52.39 | 15.06 | 15 | 21268 | 264 | 34935384 |
| Sputum increased | 50.63 | 15.06 | 26 | 21257 | 2344 | 34933304 |
| Renal failure | 50.18 | 15.06 | 184 | 21099 | 130373 | 34805275 |
| Ischaemic cerebral infarction | 49.49 | 15.06 | 21 | 21262 | 1226 | 34934422 |
| Klebsiella infection | 48.93 | 15.06 | 41 | 21242 | 8490 | 34927158 |
| Fall | 48.50 | 15.06 | 32 | 21251 | 202853 | 34732795 |
| Vestibular disorder | 48.49 | 15.06 | 20 | 21263 | 1087 | 34934561 |
| Fatigue | 48.01 | 15.06 | 96 | 21187 | 370557 | 34565091 |
| Renal impairment | 47.67 | 15.06 | 146 | 21137 | 94367 | 34841281 |
| Death | 47.49 | 15.06 | 108 | 21175 | 397941 | 34537707 |
| Aminoaciduria | 47.41 | 15.06 | 14 | 21269 | 276 | 34935372 |
| Product dose omission issue | 47.31 | 15.06 | 8 | 21275 | 119703 | 34815945 |
| Linear IgA disease | 47.23 | 15.06 | 22 | 21261 | 1604 | 34934044 |
| Asthenia | 47.09 | 15.06 | 48 | 21235 | 245203 | 34690445 |
| Respiratory tract infection bacterial | 45.31 | 15.06 | 22 | 21261 | 1760 | 34933888 |
| Lower respiratory tract infection bacterial | 43.74 | 15.06 | 15 | 21268 | 486 | 34935162 |
| Lymphadenectomy | 43.42 | 15.06 | 14 | 21269 | 373 | 34935275 |
| Affective disorder | 43.01 | 15.06 | 29 | 21254 | 4331 | 34931317 |
| Toxic epidermal necrolysis | 42.67 | 15.06 | 59 | 21224 | 21587 | 34914061 |
| Purpura | 42.25 | 15.06 | 41 | 21242 | 10270 | 34925378 |
| Cerebral ischaemia | 41.78 | 15.06 | 33 | 21250 | 6289 | 34929359 |
| Disease complication | 41.70 | 15.06 | 24 | 21259 | 2712 | 34932936 |
| Bronchial disorder | 40.80 | 15.06 | 19 | 21264 | 1384 | 34934264 |
| Lymphocyte count abnormal | 40.44 | 15.06 | 18 | 21265 | 1180 | 34934468 |
| Chest X-ray abnormal | 40.42 | 15.06 | 28 | 21255 | 4370 | 34931278 |
| Cardiac valve vegetation | 40.16 | 15.06 | 14 | 21269 | 477 | 34935171 |
| Antimicrobial susceptibility test resistant | 39.81 | 15.06 | 13 | 21270 | 361 | 34935287 |
| Neonatal disorder | 39.79 | 15.06 | 16 | 21267 | 814 | 34934834 |
| Dizziness | 39.45 | 15.06 | 45 | 21238 | 218476 | 34717172 |
| Metabolic disorder | 38.73 | 15.06 | 27 | 21256 | 4256 | 34931392 |
| Auditory neuropathy spectrum disorder | 38.43 | 15.06 | 6 | 21277 | 0 | 34935648 |
| Deafness neurosensory | 38.03 | 15.06 | 23 | 21260 | 2848 | 34932800 |
| Fungal peritonitis | 37.22 | 15.06 | 15 | 21268 | 768 | 34934880 |
| Resuscitation | 37.13 | 15.06 | 18 | 21265 | 1435 | 34934213 |
| Cholestasis | 36.88 | 15.06 | 62 | 21221 | 26886 | 34908762 |
| Antibiotic level above therapeutic | 36.20 | 15.06 | 11 | 21272 | 240 | 34935408 |
| Acute generalised exanthematous pustulosis | 35.66 | 15.06 | 31 | 21252 | 6745 | 34928903 |
| Brain injury | 34.16 | 15.06 | 29 | 21254 | 6113 | 34929535 |
| Lung consolidation | 32.96 | 15.06 | 28 | 21255 | 5908 | 34929740 |
| Symmetrical drug-related intertriginous and flexural exanthema | 32.39 | 15.06 | 11 | 21272 | 346 | 34935302 |
| Headache | 32.36 | 15.06 | 45 | 21238 | 200590 | 34735058 |
| Aspergillus infection | 31.34 | 15.06 | 38 | 21245 | 12216 | 34923432 |
| Peritonitis | 31.34 | 15.06 | 44 | 21239 | 16321 | 34919327 |
| Scoliosis | 31.01 | 15.06 | 20 | 21263 | 2773 | 34932875 |
| Acinetobacter infection | 30.98 | 15.06 | 15 | 21268 | 1192 | 34934456 |
| Drug ineffective | 30.91 | 15.06 | 418 | 20865 | 456333 | 34479315 |
| Sepsis | 30.26 | 15.06 | 189 | 21094 | 166372 | 34769276 |
| Agranulocytosis | 30.22 | 15.06 | 53 | 21230 | 23768 | 34911880 |
| Haemodynamic instability | 30.20 | 15.06 | 33 | 21250 | 9490 | 34926158 |
| Metabolic acidosis | 29.41 | 15.06 | 75 | 21208 | 43605 | 34892043 |
| Necrotising colitis | 29.38 | 15.06 | 14 | 21269 | 1074 | 34934574 |
| Leukopenia | 28.82 | 15.06 | 94 | 21189 | 62762 | 34872886 |
| Demyelination | 28.41 | 15.06 | 20 | 21263 | 3201 | 34932447 |
| Intestinal ischaemia | 28.25 | 15.06 | 29 | 21254 | 7765 | 34927883 |
| Clostridium difficile colitis | 28.22 | 15.06 | 41 | 21242 | 15689 | 34919959 |
| Insomnia | 28.20 | 15.06 | 14 | 21269 | 103893 | 34831755 |
| Pulmonary haemorrhage | 28.08 | 15.06 | 33 | 21250 | 10271 | 34925377 |
| Premature baby | 27.97 | 15.06 | 46 | 21237 | 19587 | 34916061 |
| Hypoprothrombinaemia | 27.85 | 15.06 | 10 | 21273 | 372 | 34935276 |
| Bradycardia neonatal | 27.71 | 15.06 | 13 | 21270 | 963 | 34934685 |
| Arthralgia | 27.54 | 15.06 | 38 | 21245 | 170003 | 34765645 |
| Motor dysfunction | 27.20 | 15.06 | 27 | 21256 | 6947 | 34928701 |
| Infective aneurysm | 26.73 | 15.06 | 11 | 21272 | 594 | 34935054 |
| Nutritional condition abnormal | 26.36 | 15.06 | 10 | 21273 | 435 | 34935213 |
| Anisocytosis | 25.85 | 15.06 | 10 | 21273 | 459 | 34935189 |
| Lymphocyte count decreased | 25.73 | 15.06 | 48 | 21235 | 22574 | 34913074 |
| Fungaemia | 25.14 | 15.06 | 17 | 21266 | 2551 | 34933097 |
| Mucormycosis | 25.04 | 15.06 | 24 | 21259 | 5918 | 34929730 |
| Oliguria | 24.79 | 15.06 | 28 | 21255 | 8352 | 34927296 |
| Infusion site induration | 24.04 | 15.06 | 8 | 21275 | 236 | 34935412 |
| Schizophrenia | 24.02 | 15.06 | 28 | 21255 | 8638 | 34927010 |
| Listeriosis | 23.96 | 15.06 | 12 | 21271 | 1026 | 34934622 |
| Pseudomembranous colitis | 23.86 | 15.06 | 17 | 21266 | 2774 | 34932874 |
| Petechiae | 23.75 | 15.06 | 29 | 21254 | 9389 | 34926259 |
| Neonatal hypoxia | 23.58 | 15.06 | 9 | 21274 | 398 | 34935250 |
| Endocarditis candida | 23.08 | 15.06 | 6 | 21277 | 72 | 34935576 |
| Sepsis neonatal | 23.07 | 15.06 | 8 | 21275 | 268 | 34935380 |
| Cough | 22.89 | 15.06 | 35 | 21248 | 150105 | 34785543 |
| Hepatocellular injury | 22.65 | 15.06 | 45 | 21238 | 22166 | 34913482 |
| Weight decreased | 22.45 | 15.06 | 46 | 21237 | 176255 | 34759393 |
| Injury | 22.42 | 15.06 | 43 | 21240 | 20644 | 34915004 |
| Nosocomial infection | 22.40 | 15.06 | 12 | 21271 | 1179 | 34934469 |
| Intraventricular haemorrhage neonatal | 22.09 | 15.06 | 8 | 21275 | 305 | 34935343 |
| ADAMTS13 activity decreased | 21.91 | 15.06 | 6 | 21277 | 89 | 34935559 |
| Weight increased | 21.75 | 15.06 | 15 | 21268 | 93018 | 34842630 |
| Nausea | 21.73 | 15.06 | 120 | 21163 | 339788 | 34595860 |
| Pain | 21.60 | 15.06 | 59 | 21224 | 204616 | 34731032 |
| Lymphocyte morphology abnormal | 21.55 | 15.06 | 9 | 21274 | 505 | 34935143 |
| Polycythaemia | 21.51 | 15.06 | 14 | 21269 | 1971 | 34933677 |
| Blood alkaline phosphatase increased | 21.47 | 15.06 | 54 | 21229 | 31121 | 34904527 |
| Nasal discomfort | 21.45 | 15.06 | 13 | 21270 | 1615 | 34934033 |
| SARS-CoV-2 test positive | 21.37 | 15.06 | 22 | 21261 | 5911 | 34929737 |
| Therapeutic product effect incomplete | 20.81 | 15.06 | 3 | 21280 | 50538 | 34885110 |
| Staphylococcal infection | 20.76 | 15.06 | 55 | 21228 | 32705 | 34902943 |
| Neutrophil count increased | 20.27 | 15.06 | 37 | 21246 | 17109 | 34918539 |
| Embolia cutis medicamentosa | 20.26 | 15.06 | 7 | 21276 | 232 | 34935416 |
| Red blood cell schistocytes present | 20.09 | 15.06 | 7 | 21276 | 238 | 34935410 |
| Arterial angioplasty | 20.06 | 15.06 | 5 | 21278 | 50 | 34935598 |
| Chondrocalcinosis | 19.84 | 15.06 | 8 | 21275 | 410 | 34935238 |
| Neonatal candida infection | 19.84 | 15.06 | 4 | 21279 | 13 | 34935635 |
| Depression | 19.75 | 15.06 | 18 | 21265 | 97080 | 34838568 |
| Haemodialysis | 19.71 | 15.06 | 28 | 21255 | 10498 | 34925150 |
| Nasopharyngitis | 19.63 | 15.06 | 9 | 21274 | 69959 | 34865689 |
| Malignant neoplasm progression | 19.54 | 15.06 | 15 | 21268 | 88031 | 34847617 |
| Scrotal pain | 19.53 | 15.06 | 10 | 21273 | 896 | 34934752 |
| Uveal prolapse | 19.21 | 15.06 | 3 | 21280 | 0 | 34935648 |
| Haemorrhage neonatal | 19.21 | 15.06 | 3 | 21280 | 0 | 34935648 |
| Aortic valve disease | 19.14 | 15.06 | 11 | 21272 | 1240 | 34934408 |
| Myeloma cast nephropathy | 19.09 | 15.06 | 5 | 21278 | 62 | 34935586 |
| Hypersensitivity vasculitis | 19.06 | 15.06 | 16 | 21267 | 3319 | 34932329 |
| Rash erythematous | 19.05 | 15.06 | 45 | 21238 | 24932 | 34910716 |
| Muscle atrophy | 19.00 | 15.06 | 23 | 21260 | 7381 | 34928267 |
| Antineutrophil cytoplasmic antibody | 19.00 | 15.06 | 4 | 21279 | 17 | 34935631 |
| Thrombocytopenia | 18.95 | 15.06 | 161 | 21122 | 156086 | 34779562 |
| Abdominal pain upper | 18.84 | 15.06 | 10 | 21273 | 71480 | 34864168 |
| Bacillus infection | 18.82 | 15.06 | 7 | 21276 | 288 | 34935360 |
| Stenotrophomonas test positive | 18.78 | 15.06 | 7 | 21276 | 290 | 34935358 |
| Mast cell degranulation present | 18.66 | 15.06 | 5 | 21278 | 68 | 34935580 |
| Macrocytosis | 18.66 | 15.06 | 10 | 21273 | 984 | 34934664 |
| Herpes zoster reactivation | 18.64 | 15.06 | 7 | 21276 | 296 | 34935352 |
| Application site scab | 18.53 | 15.06 | 5 | 21278 | 70 | 34935578 |
| Foot amputation | 18.16 | 15.06 | 9 | 21274 | 752 | 34934896 |
| Cross sensitivity reaction | 18.01 | 15.06 | 11 | 21272 | 1386 | 34934262 |
| Cardiac valve abscess | 17.99 | 15.06 | 4 | 21279 | 23 | 34935625 |
| Blood creatinine increased | 17.99 | 15.06 | 109 | 21174 | 94867 | 34840781 |
| Secretion discharge | 17.92 | 15.06 | 20 | 21263 | 5885 | 34929763 |
| Disseminated mucormycosis | 17.87 | 15.06 | 8 | 21275 | 532 | 34935116 |
| Eosinophilic pneumonia acute | 17.81 | 15.06 | 8 | 21275 | 536 | 34935112 |
| Chronic obstructive pulmonary disease | 17.77 | 15.06 | 4 | 21279 | 48914 | 34886734 |
| Muscle spasms | 17.65 | 15.06 | 12 | 21271 | 74989 | 34860659 |
| Inappropriate schedule of product administration | 17.50 | 15.06 | 8 | 21275 | 62288 | 34873360 |
| Coronary artery disease | 17.45 | 15.06 | 4 | 21279 | 48301 | 34887347 |
| Cardiac arrest neonatal | 17.32 | 15.06 | 4 | 21279 | 28 | 34935620 |
| Jarisch-Herxheimer reaction | 17.17 | 15.06 | 8 | 21275 | 583 | 34935065 |
| Acute vestibular syndrome | 17.14 | 15.06 | 3 | 21280 | 3 | 34935645 |
| Hallucination, auditory | 17.08 | 15.06 | 28 | 21255 | 11889 | 34923759 |
| Peripheral swelling | 17.03 | 15.06 | 13 | 21270 | 76528 | 34859120 |
| Respiratory distress | 16.93 | 15.06 | 54 | 21229 | 35611 | 34900037 |
| Systemic mycosis | 16.81 | 15.06 | 11 | 21272 | 1562 | 34934086 |
| Stupor | 16.80 | 15.06 | 14 | 21269 | 2877 | 34932771 |
| CD4 lymphocytes increased | 16.79 | 15.06 | 6 | 21277 | 220 | 34935428 |
| Extrapyramidal disorder | 16.78 | 15.06 | 29 | 21254 | 12851 | 34922797 |
| Leukocyturia | 16.46 | 15.06 | 8 | 21275 | 641 | 34935007 |
| Neonatal respiratory distress syndrome | 16.45 | 15.06 | 16 | 21267 | 4018 | 34931630 |
| Aortic valve incompetence | 16.24 | 15.06 | 19 | 21264 | 5885 | 34929763 |
| Localised oedema | 16.23 | 15.06 | 15 | 21268 | 3533 | 34932115 |
| Dry gangrene | 16.13 | 15.06 | 7 | 21276 | 432 | 34935216 |
| Fixed eruption | 16.04 | 15.06 | 11 | 21272 | 1689 | 34933959 |
| Rash morbilliform | 16.00 | 15.06 | 14 | 21269 | 3073 | 34932575 |
| Respiratory alkalosis | 15.98 | 15.06 | 11 | 21272 | 1698 | 34933950 |
| Shock | 15.73 | 15.06 | 41 | 21242 | 24138 | 34911510 |
| Renal injury | 15.63 | 15.06 | 26 | 21257 | 11169 | 34924479 |
| Constipation | 15.58 | 15.06 | 38 | 21245 | 136944 | 34798704 |
| Hepatic cytolysis | 15.54 | 15.06 | 30 | 21253 | 14466 | 34921182 |
| Reticulocytosis | 15.54 | 15.06 | 6 | 21277 | 274 | 34935374 |
| Trichosporon infection | 15.53 | 15.06 | 8 | 21275 | 726 | 34934922 |
| Inflammation | 15.45 | 15.06 | 45 | 21238 | 28250 | 34907398 |
| Hyperhidrosis | 15.43 | 15.06 | 14 | 21269 | 75678 | 34859970 |
| Hypotension | 15.36 | 15.06 | 204 | 21079 | 221445 | 34714203 |
| Haemophagocytic lymphohistiocytosis | 15.34 | 15.06 | 28 | 21255 | 12945 | 34922703 |
| Pain in extremity | 15.27 | 15.06 | 34 | 21249 | 126479 | 34809169 |
| Staphylococcal bacteraemia | 15.12 | 15.06 | 22 | 21261 | 8430 | 34927218 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Acute kidney injury | 1076.89 | 12.97 | 1223 | 33671 | 518181 | 79191313 |
| Drug reaction with eosinophilia and systemic symptoms | 439.46 | 12.97 | 300 | 34594 | 63944 | 79645550 |
| Renal tubular necrosis | 318.47 | 12.97 | 174 | 34720 | 24865 | 79684629 |
| Pathogen resistance | 298.12 | 12.97 | 139 | 34755 | 14203 | 79695291 |
| Eosinophilia | 204.64 | 12.97 | 165 | 34729 | 45180 | 79664314 |
| Multiple organ dysfunction syndrome | 197.50 | 12.97 | 253 | 34641 | 119993 | 79589501 |
| Toxic epidermal necrolysis | 161.59 | 12.97 | 143 | 34751 | 44438 | 79665056 |
| Ototoxicity | 158.13 | 12.97 | 58 | 34836 | 3216 | 79706278 |
| Septic shock | 148.50 | 12.97 | 223 | 34671 | 122578 | 79586916 |
| Peritonitis bacterial | 139.94 | 12.97 | 73 | 34821 | 9494 | 79700000 |
| Endocarditis | 124.71 | 12.97 | 70 | 34824 | 10527 | 79698967 |
| Renal failure | 124.70 | 12.97 | 273 | 34621 | 200695 | 79508799 |
| Nephropathy toxic | 124.61 | 12.97 | 89 | 34805 | 20330 | 79689164 |
| Antibiotic level above therapeutic | 124.58 | 12.97 | 34 | 34860 | 706 | 79708788 |
| Toxic skin eruption | 124.30 | 12.97 | 92 | 34802 | 22201 | 79687293 |
| Pyrexia | 123.85 | 12.97 | 605 | 34289 | 678104 | 79031390 |
| Anaphylactic reaction | 121.67 | 12.97 | 166 | 34728 | 83577 | 79625917 |
| Drug resistance | 121.30 | 12.97 | 119 | 34775 | 42094 | 79667400 |
| Crystalluria | 116.14 | 12.97 | 34 | 34860 | 917 | 79708577 |
| Rash maculo-papular | 114.80 | 12.97 | 132 | 34762 | 55946 | 79653548 |
| Tubulointerstitial nephritis | 112.13 | 12.97 | 109 | 34785 | 38126 | 79671368 |
| Vestibular disorder | 102.18 | 12.97 | 39 | 34855 | 2416 | 79707078 |
| Completed suicide | 93.96 | 12.97 | 3 | 34891 | 245764 | 79463730 |
| Sepsis | 93.92 | 12.97 | 295 | 34599 | 269133 | 79440361 |
| Linear IgA disease | 86.33 | 12.97 | 37 | 34857 | 3095 | 79706399 |
| Bartter's syndrome | 85.63 | 12.97 | 14 | 34880 | 12 | 79709482 |
| Spinal muscular atrophy | 84.36 | 12.97 | 22 | 34872 | 381 | 79709113 |
| Fall | 84.17 | 12.97 | 55 | 34839 | 487574 | 79221920 |
| Renal impairment | 84.16 | 12.97 | 202 | 34692 | 157581 | 79551913 |
| Drug intolerance | 83.76 | 12.97 | 9 | 34885 | 264110 | 79445384 |
| Peritonitis | 80.47 | 12.97 | 79 | 34815 | 27957 | 79681537 |
| Delusion of grandeur | 79.03 | 12.97 | 28 | 34866 | 1404 | 79708090 |
| Headache | 74.31 | 12.97 | 107 | 34787 | 653665 | 79055829 |
| Joint swelling | 73.40 | 12.97 | 18 | 34876 | 288628 | 79420866 |
| Fatigue | 68.34 | 12.97 | 196 | 34698 | 929531 | 78779963 |
| Product dose omission issue | 67.89 | 12.97 | 13 | 34881 | 247524 | 79461970 |
| Purpura | 67.49 | 12.97 | 61 | 34833 | 19466 | 79690028 |
| Pain | 67.18 | 12.97 | 129 | 34765 | 703673 | 79005821 |
| Rheumatoid arthritis | 66.35 | 12.97 | 7 | 34887 | 208463 | 79501031 |
| Nasopharyngitis | 64.22 | 12.97 | 16 | 34878 | 253865 | 79455629 |
| Pneumococcal sepsis | 64.17 | 12.97 | 25 | 34869 | 1637 | 79707857 |
| Weight increased | 61.95 | 12.97 | 22 | 34872 | 277364 | 79432130 |
| Cholestasis | 60.61 | 12.97 | 93 | 34801 | 52016 | 79657478 |
| Stevens-Johnson syndrome | 58.92 | 12.97 | 79 | 34815 | 39087 | 79670407 |
| Deafness neurosensory | 58.76 | 12.97 | 37 | 34857 | 6861 | 79702633 |
| Drug abuse | 58.76 | 12.97 | 3 | 34891 | 162688 | 79546806 |
| Motor neurone disease | 58.13 | 12.97 | 18 | 34876 | 590 | 79708904 |
| Haemodynamic instability | 57.53 | 12.97 | 53 | 34841 | 17329 | 79692165 |
| Stoma closure | 55.77 | 12.97 | 15 | 34879 | 294 | 79709200 |
| Abdominal discomfort | 52.47 | 12.97 | 22 | 34872 | 250705 | 79458789 |
| Acute generalised exanthematous pustulosis | 52.10 | 12.97 | 50 | 34844 | 17204 | 79692290 |
| Renal injury | 51.01 | 12.97 | 49 | 34845 | 16878 | 79692616 |
| Cardiac valve vegetation | 50.83 | 12.97 | 18 | 34876 | 901 | 79708593 |
| Clostridium difficile infection | 49.38 | 12.97 | 76 | 34818 | 42609 | 79666885 |
| Arthropathy | 49.19 | 12.97 | 9 | 34885 | 177102 | 79532392 |
| Arthralgia | 48.46 | 12.97 | 112 | 34782 | 571691 | 79137803 |
| Aminoaciduria | 47.73 | 12.97 | 14 | 34880 | 380 | 79709114 |
| Excessive eye blinking | 46.57 | 12.97 | 20 | 34874 | 1681 | 79707813 |
| Rhinalgia | 46.27 | 12.97 | 22 | 34872 | 2345 | 79707149 |
| Asthenia | 45.99 | 12.97 | 97 | 34797 | 511592 | 79197902 |
| Respiratory tract infection bacterial | 45.86 | 12.97 | 21 | 34873 | 2056 | 79707438 |
| Lymphocyte count abnormal | 45.57 | 12.97 | 19 | 34875 | 1484 | 79708010 |
| Agranulocytosis | 45.00 | 12.97 | 75 | 34819 | 44955 | 79664539 |
| Mucosal inflammation | 44.90 | 12.97 | 101 | 34793 | 75479 | 79634015 |
| Increased bronchial secretion | 44.72 | 12.97 | 24 | 34870 | 3303 | 79706191 |
| Noninfectious peritonitis | 44.16 | 12.97 | 12 | 34882 | 245 | 79709249 |
| Therapeutic product effect decreased | 44.08 | 12.97 | 9 | 34885 | 163854 | 79545640 |
| Blood creatinine increased | 43.53 | 12.97 | 158 | 34736 | 154899 | 79554595 |
| Klebsiella infection | 42.71 | 12.97 | 43 | 34851 | 15677 | 79693817 |
| Device related infection | 42.42 | 12.97 | 63 | 34831 | 34231 | 79675263 |
| Peripheral swelling | 41.78 | 12.97 | 34 | 34860 | 269583 | 79439911 |
| Oliguria | 41.38 | 12.97 | 43 | 34851 | 16266 | 79693228 |
| Metabolic alkalosis | 40.57 | 12.97 | 25 | 34869 | 4464 | 79705030 |
| Abdominal pain upper | 40.27 | 12.97 | 24 | 34870 | 223795 | 79485699 |
| Therapeutic product effect incomplete | 39.76 | 12.97 | 7 | 34887 | 141638 | 79567856 |
| Petechiae | 39.71 | 12.97 | 47 | 34847 | 20518 | 79688976 |
| Antimicrobial susceptibility test resistant | 39.27 | 12.97 | 12 | 34882 | 376 | 79709118 |
| Lung consolidation | 39.16 | 12.97 | 32 | 34862 | 8915 | 79700579 |
| Lower respiratory tract infection bacterial | 39.12 | 12.97 | 15 | 34879 | 941 | 79708553 |
| Aspergillus infection | 39.02 | 12.97 | 45 | 34849 | 19116 | 79690378 |
| Shock haemorrhagic | 38.99 | 12.97 | 46 | 34848 | 20014 | 79689480 |
| Ischaemic cerebral infarction | 38.96 | 12.97 | 20 | 34874 | 2515 | 79706979 |
| Renal tubular disorder | 38.94 | 12.97 | 28 | 34866 | 6458 | 79703036 |
| Infective aneurysm | 38.34 | 12.97 | 15 | 34879 | 993 | 79708501 |
| Oropharyngeal oedema | 37.62 | 12.97 | 12 | 34882 | 434 | 79709060 |
| Sputum increased | 37.44 | 12.97 | 24 | 34870 | 4589 | 79704905 |
| Fungal peritonitis | 37.07 | 12.97 | 15 | 34879 | 1085 | 79708409 |
| Bronchial disorder | 36.42 | 12.97 | 19 | 34875 | 2470 | 79707024 |
| Pain in extremity | 36.29 | 12.97 | 65 | 34829 | 364473 | 79345021 |
| Anaphylactic shock | 36.03 | 12.97 | 60 | 34834 | 35936 | 79673558 |
| Disease complication | 35.96 | 12.97 | 24 | 34870 | 4913 | 79704581 |
| Intentional product use issue | 35.80 | 12.97 | 11 | 34883 | 152101 | 79557393 |
| Affective disorder | 34.83 | 12.97 | 29 | 34865 | 8290 | 79701204 |
| Arthritis bacterial | 34.39 | 12.97 | 30 | 34864 | 9136 | 79700358 |
| Haemodialysis | 34.22 | 12.97 | 41 | 34853 | 18127 | 79691367 |
| Rash erythematous | 34.08 | 12.97 | 77 | 34817 | 57692 | 79651802 |
| Musculoskeletal stiffness | 34.04 | 12.97 | 17 | 34877 | 174991 | 79534503 |
| Enterococcal infection | 33.96 | 12.97 | 38 | 34856 | 15622 | 79693872 |
| Retinal infarction | 32.52 | 12.97 | 9 | 34885 | 197 | 79709297 |
| Endophthalmitis | 32.44 | 12.97 | 25 | 34869 | 6403 | 79703091 |
| Sepsis syndrome | 32.43 | 12.97 | 15 | 34879 | 1502 | 79707992 |
| Lymphadenectomy | 31.85 | 12.97 | 14 | 34880 | 1245 | 79708249 |
| Premature delivery | 31.78 | 12.97 | 45 | 34849 | 23422 | 79686072 |
| Glossodynia | 31.54 | 12.97 | 4 | 34890 | 103333 | 79606161 |
| Nausea | 31.51 | 12.97 | 268 | 34626 | 956928 | 78752566 |
| Vascular device infection | 31.44 | 12.97 | 30 | 34864 | 10246 | 79699248 |
| Aortic valve incompetence | 31.42 | 12.97 | 29 | 34865 | 9501 | 79699993 |
| Resuscitation | 31.36 | 12.97 | 17 | 34877 | 2387 | 79707107 |
| Cerebral ischaemia | 31.10 | 12.97 | 31 | 34863 | 11164 | 79698330 |
| Insomnia | 30.96 | 12.97 | 37 | 34857 | 245133 | 79464361 |
| Candida infection | 30.88 | 12.97 | 58 | 34836 | 38156 | 79671338 |
| Neutropenia | 30.53 | 12.97 | 223 | 34671 | 287487 | 79422007 |
| Brain injury | 30.37 | 12.97 | 31 | 34863 | 11486 | 79698008 |
| Dizziness | 30.35 | 12.97 | 123 | 34771 | 526318 | 79183176 |
| Tendon necrosis | 30.21 | 12.97 | 5 | 34889 | 5 | 79709489 |
| Chest X-ray abnormal | 29.97 | 12.97 | 26 | 34868 | 7857 | 79701637 |
| Contraindicated product administered | 29.61 | 12.97 | 16 | 34878 | 157522 | 79551972 |
| Myeloma cast nephropathy | 29.55 | 12.97 | 8 | 34886 | 161 | 79709333 |
| Endocarditis bacterial | 29.25 | 12.97 | 14 | 34880 | 1515 | 79707979 |
| Acinetobacter infection | 29.07 | 12.97 | 17 | 34877 | 2760 | 79706734 |
| Hypotension | 28.88 | 12.97 | 307 | 34587 | 440010 | 79269484 |
| Mental status changes postoperative | 28.83 | 12.97 | 8 | 34886 | 177 | 79709317 |
| Neutropenic sepsis | 28.28 | 12.97 | 46 | 34848 | 27018 | 79682476 |
| Blood alkaline phosphatase increased | 28.17 | 12.97 | 76 | 34818 | 63588 | 79645906 |
| Septic embolus | 28.14 | 12.97 | 15 | 34879 | 2036 | 79707458 |
| Anuria | 28.09 | 12.97 | 40 | 34854 | 20923 | 79688571 |
| Asthma | 28.01 | 12.97 | 12 | 34882 | 135083 | 79574411 |
| Infusion related reaction | 27.76 | 12.97 | 36 | 34858 | 230201 | 79479293 |
| Confusion postoperative | 27.39 | 12.97 | 8 | 34886 | 214 | 79709280 |
| Staphylococcal infection | 27.22 | 12.97 | 71 | 34823 | 58224 | 79651270 |
| Leukopenia | 27.18 | 12.97 | 112 | 34782 | 116401 | 79593093 |
| Face oedema | 26.96 | 12.97 | 46 | 34848 | 28090 | 79681404 |
| Rash morbilliform | 26.92 | 12.97 | 22 | 34872 | 6128 | 79703366 |
| Metabolic disorder | 26.61 | 12.97 | 26 | 34868 | 9144 | 79700350 |
| Tachycardia | 26.36 | 12.97 | 150 | 34744 | 177618 | 79531876 |
| Skin test positive | 26.33 | 12.97 | 12 | 34882 | 1162 | 79708332 |
| Sinusitis | 26.32 | 12.97 | 28 | 34866 | 195473 | 79514021 |
| Symmetrical drug-related intertriginous and flexural exanthema | 26.19 | 12.97 | 11 | 34883 | 875 | 79708619 |
| Abscess neck | 26.11 | 12.97 | 12 | 34882 | 1185 | 79708309 |
| Clostridium difficile colitis | 26.09 | 12.97 | 49 | 34845 | 32234 | 79677260 |
| Disseminated intravascular coagulation | 26.03 | 12.97 | 52 | 34842 | 35790 | 79673704 |
| Metabolic acidosis | 25.65 | 12.97 | 87 | 34807 | 82442 | 79627052 |
| Shock | 25.64 | 12.97 | 58 | 34836 | 43490 | 79666004 |
| Hepatic cytolysis | 25.50 | 12.97 | 44 | 34850 | 27107 | 79682387 |
| Hepatocellular injury | 25.41 | 12.97 | 61 | 34833 | 47532 | 79661962 |
| Hyperaldosteronism | 25.41 | 12.97 | 9 | 34885 | 451 | 79709043 |
| Haematochezia | 25.33 | 12.97 | 4 | 34890 | 87641 | 79621853 |
| Migraine | 25.27 | 12.97 | 4 | 34890 | 87489 | 79622005 |
| Hyperchlorhydria | 25.18 | 12.97 | 14 | 34880 | 2065 | 79707429 |
| Pseudomembranous colitis | 25.17 | 12.97 | 20 | 34874 | 5354 | 79704140 |
| Thrombocytopenia | 25.00 | 12.97 | 200 | 34694 | 265059 | 79444435 |
| Swelling | 24.99 | 12.97 | 35 | 34859 | 216676 | 79492818 |
| Loss of personal independence in daily activities | 24.90 | 12.97 | 7 | 34887 | 102573 | 79606921 |
| Corneal oedema | 24.72 | 12.97 | 15 | 34879 | 2605 | 79706889 |
| Hypoprothrombinaemia | 24.60 | 12.97 | 10 | 34884 | 732 | 79708762 |
| Blood pressure increased | 24.51 | 12.97 | 34 | 34860 | 211326 | 79498168 |
| Procedural hypertension | 24.19 | 12.97 | 8 | 34886 | 325 | 79709169 |
| Depression | 24.03 | 12.97 | 36 | 34858 | 216754 | 79492740 |
| Seizure | 23.96 | 12.97 | 153 | 34741 | 188681 | 79520813 |
| Blood cholesterol increased | 23.79 | 12.97 | 4 | 34890 | 83716 | 79625778 |
| Weight decreased | 23.73 | 12.97 | 78 | 34816 | 355120 | 79354374 |
| Peritoneal dialysis complication | 23.57 | 12.97 | 14 | 34880 | 2340 | 79707154 |
| Drug level increased | 23.55 | 12.97 | 53 | 34841 | 39598 | 79669896 |
| Muscle spasms | 23.55 | 12.97 | 25 | 34869 | 174705 | 79534789 |
| Hypopyon | 23.51 | 12.97 | 11 | 34883 | 1131 | 79708363 |
| Oscillopsia | 23.49 | 12.97 | 7 | 34887 | 201 | 79709293 |
| Fungaemia | 23.48 | 12.97 | 18 | 34876 | 4573 | 79704921 |
| Suicide attempt | 23.48 | 12.97 | 4 | 34890 | 82928 | 79626566 |
| Puerperal pyrexia | 23.42 | 12.97 | 5 | 34889 | 34 | 79709460 |
| Chest discomfort | 23.18 | 12.97 | 16 | 34878 | 138028 | 79571466 |
| Nasal discomfort | 22.72 | 12.97 | 19 | 34875 | 5464 | 79704030 |
| Endocarditis candida | 22.69 | 12.97 | 6 | 34888 | 110 | 79709384 |
| Intervertebral discitis | 22.68 | 12.97 | 18 | 34876 | 4810 | 79704684 |
| Motor dysfunction | 22.58 | 12.97 | 30 | 34864 | 14703 | 79694791 |
| Chronic obstructive pulmonary disease | 22.33 | 12.97 | 5 | 34889 | 85414 | 79624080 |
| Hypoglossal nerve paresis | 22.24 | 12.97 | 6 | 34888 | 119 | 79709375 |
| Lymphocyte morphology abnormal | 22.14 | 12.97 | 10 | 34884 | 948 | 79708546 |
| Psoriasis | 21.96 | 12.97 | 6 | 34888 | 89581 | 79619913 |
| Injection site pain | 21.86 | 12.97 | 15 | 34879 | 129823 | 79579671 |
| Discomfort | 21.84 | 12.97 | 14 | 34880 | 125603 | 79583891 |
| Inappropriate schedule of product administration | 21.76 | 12.97 | 16 | 34878 | 133612 | 79575882 |
| Arterial angioplasty | 21.71 | 12.97 | 5 | 34889 | 50 | 79709444 |
| Contusion | 21.53 | 12.97 | 20 | 34874 | 148756 | 79560738 |
| Hallucination, auditory | 21.39 | 12.97 | 35 | 34859 | 20658 | 79688836 |
| Dry mouth | 21.37 | 12.97 | 6 | 34888 | 88013 | 79621481 |
| Scoliosis | 21.35 | 12.97 | 21 | 34873 | 7443 | 79702051 |
| Folate deficiency | 21.31 | 12.97 | 15 | 34879 | 3345 | 79706149 |
| Drug interaction | 21.22 | 12.97 | 276 | 34618 | 414907 | 79294587 |
| Arthritis | 21.10 | 12.97 | 12 | 34882 | 114868 | 79594626 |
| Pyroglutamic acidosis | 21.03 | 12.97 | 10 | 34884 | 1066 | 79708428 |
| Blood culture positive | 20.98 | 12.97 | 22 | 34872 | 8407 | 79701087 |
| Suicidal ideation | 20.93 | 12.97 | 4 | 34890 | 76336 | 79633158 |
| Cough | 20.92 | 12.97 | 86 | 34808 | 366703 | 79342791 |
| Acute respiratory distress syndrome | 20.91 | 12.97 | 54 | 34840 | 44013 | 79665481 |
| Circulatory collapse | 20.88 | 12.97 | 49 | 34845 | 37619 | 79671875 |
| Escherichia infection | 20.72 | 12.97 | 32 | 34862 | 17985 | 79691509 |
| Lemierre syndrome | 20.70 | 12.97 | 6 | 34888 | 156 | 79709338 |
| Nutritional condition abnormal | 20.68 | 12.97 | 10 | 34884 | 1107 | 79708387 |
| Aortic valve disease | 20.63 | 12.97 | 12 | 34882 | 1929 | 79707565 |
| Helicobacter infection | 20.55 | 12.97 | 3 | 34891 | 69701 | 79639793 |
| Toxicity to various agents | 20.38 | 12.97 | 105 | 34789 | 421435 | 79288059 |
| Bacillus infection | 20.36 | 12.97 | 10 | 34884 | 1145 | 79708349 |
| Intestinal ischaemia | 20.31 | 12.97 | 27 | 34867 | 13243 | 79696251 |
| Mast cell degranulation present | 20.30 | 12.97 | 5 | 34889 | 68 | 79709426 |
| Cellulitis | 20.28 | 12.97 | 98 | 34796 | 108962 | 79600532 |
| Macroglossia | 20.15 | 12.97 | 10 | 34884 | 1171 | 79708323 |
| Wound | 20.13 | 12.97 | 13 | 34881 | 116166 | 79593328 |
| Wrong technique in product usage process | 19.98 | 12.97 | 4 | 34890 | 73871 | 79635623 |
| Learning disorder | 19.87 | 12.97 | 8 | 34886 | 571 | 79708923 |
| SARS-CoV-2 test positive | 19.74 | 12.97 | 25 | 34869 | 11691 | 79697803 |
| Constipation | 19.71 | 12.97 | 61 | 34833 | 282989 | 79426505 |
| ADAMTS13 activity decreased | 19.70 | 12.97 | 6 | 34888 | 186 | 79709308 |
| Psoriatic arthropathy | 19.54 | 12.97 | 5 | 34889 | 77994 | 79631500 |
| Gastrointestinal disorder | 19.43 | 12.97 | 15 | 34879 | 122190 | 79587304 |
| Neutrophil count increased | 19.40 | 12.97 | 41 | 34853 | 29355 | 79680139 |
| Osteoarthritis | 19.34 | 12.97 | 7 | 34887 | 87302 | 79622192 |
| Stenotrophomonas test positive | 19.33 | 12.97 | 7 | 34887 | 374 | 79709120 |
| Duodenal ulcer perforation | 19.18 | 12.97 | 3 | 34891 | 66208 | 79643286 |
| Pseudo-Bartter syndrome | 19.15 | 12.97 | 5 | 34889 | 87 | 79709407 |
| Feeling abnormal | 19.07 | 12.97 | 25 | 34869 | 159174 | 79550320 |
| Listeriosis | 18.99 | 12.97 | 12 | 34882 | 2238 | 79707256 |
| Pericarditis | 18.98 | 12.97 | 11 | 34883 | 104225 | 79605269 |
| Staphylococcal bacteraemia | 18.91 | 12.97 | 25 | 34869 | 12193 | 79697301 |
| Hypersensitivity vasculitis | 18.87 | 12.97 | 19 | 34875 | 6924 | 79702570 |
| Geotrichum infection | 18.82 | 12.97 | 9 | 34885 | 972 | 79708522 |
| Haemophagocytic lymphohistiocytosis | 18.72 | 12.97 | 34 | 34860 | 21803 | 79687691 |
| Memory impairment | 18.69 | 12.97 | 13 | 34881 | 111721 | 79597773 |
| Trichosporon infection | 18.58 | 12.97 | 9 | 34885 | 999 | 79708495 |
| Schizophrenia | 18.57 | 12.97 | 28 | 34866 | 15412 | 79694082 |
| Fluid retention | 18.43 | 12.97 | 4 | 34890 | 69805 | 79639689 |
| Demyelination | 18.31 | 12.97 | 20 | 34874 | 8003 | 79701491 |
| Drug ineffective | 18.18 | 12.97 | 609 | 34285 | 1080304 | 78629190 |
| Dyspnoea | 18.17 | 12.97 | 265 | 34629 | 856760 | 78852734 |
| Influenza | 18.08 | 12.97 | 18 | 34876 | 129588 | 79579906 |
| Malaise | 17.97 | 12.97 | 133 | 34761 | 489736 | 79219758 |
| Disseminated mucormycosis | 17.90 | 12.97 | 8 | 34886 | 740 | 79708754 |
| Antineutrophil cytoplasmic antibody | 17.85 | 12.97 | 4 | 34890 | 35 | 79709459 |
| Impaired healing | 17.83 | 12.97 | 8 | 34886 | 87647 | 79621847 |
| Rash macular | 17.58 | 12.97 | 39 | 34855 | 28860 | 79680634 |
| Skin lesion | 17.56 | 12.97 | 49 | 34845 | 41795 | 79667699 |
| Muscle atrophy | 17.41 | 12.97 | 23 | 34871 | 11209 | 79698285 |
| Reticulocytosis | 17.36 | 12.97 | 7 | 34887 | 502 | 79708992 |
| Exfoliative rash | 17.30 | 12.97 | 14 | 34880 | 3845 | 79705649 |
| CD4 lymphocytes increased | 17.10 | 12.97 | 6 | 34888 | 292 | 79709202 |
| Mycobacterium abscessus infection | 16.95 | 12.97 | 9 | 34885 | 1213 | 79708281 |
| Pulmonary valve disease | 16.91 | 12.97 | 6 | 34888 | 302 | 79709192 |
| Psychotic disorder | 16.90 | 12.97 | 48 | 34846 | 41354 | 79668140 |
| Toxic shock syndrome | 16.76 | 12.97 | 9 | 34885 | 1240 | 79708254 |
| Pancytopenia | 16.72 | 12.97 | 127 | 34767 | 165618 | 79543876 |
| Hepatitis | 16.66 | 12.97 | 58 | 34836 | 55669 | 79653825 |
| Type IV hypersensitivity reaction | 16.62 | 12.97 | 14 | 34880 | 4067 | 79705427 |
| Uveal prolapse | 16.60 | 12.97 | 3 | 34891 | 7 | 79709487 |
| Extrapyramidal disorder | 16.58 | 12.97 | 33 | 34861 | 22646 | 79686848 |
| Dermatitis exfoliative | 16.52 | 12.97 | 22 | 34872 | 10807 | 79698687 |
| HIV associated nephropathy | 16.38 | 12.97 | 6 | 34888 | 331 | 79709163 |
| Red blood cell schistocytes present | 16.37 | 12.97 | 7 | 34887 | 582 | 79708912 |
| Serratia infection | 16.33 | 12.97 | 10 | 34884 | 1766 | 79707728 |
| Bronchitis | 16.18 | 12.97 | 20 | 34874 | 130624 | 79578870 |
| Fungal endocarditis | 16.09 | 12.97 | 7 | 34887 | 607 | 79708887 |
| Tonsillitis bacterial | 16 | 12.97 | 5 | 34889 | 169 | 79709325 |
| Respiratory alkalosis | 15.95 | 12.97 | 14 | 34880 | 4297 | 79705197 |
| Foot amputation | 15.93 | 12.97 | 8 | 34886 | 960 | 79708534 |
| Musculoskeletal pain | 15.72 | 12.97 | 13 | 34881 | 102341 | 79607153 |
| Nasal congestion | 15.55 | 12.97 | 7 | 34887 | 76545 | 79632949 |
| Blood pressure fluctuation | 15.54 | 12.97 | 5 | 34889 | 67140 | 79642354 |
| Cardiac failure congestive | 15.43 | 12.97 | 24 | 34870 | 142378 | 79567116 |
| Liver abscess | 15.43 | 12.97 | 16 | 34878 | 6038 | 79703456 |
| Urogenital disorder | 15.35 | 12.97 | 4 | 34890 | 69 | 79709425 |
| Staphylococcal sepsis | 15.34 | 12.97 | 25 | 34869 | 14701 | 79694793 |
| Infusion site necrosis | 15.30 | 12.97 | 4 | 34890 | 70 | 79709424 |
| Chondrocalcinosis | 15.28 | 12.97 | 8 | 34886 | 1048 | 79708446 |
| Hepatic enzyme increased | 15.23 | 12.97 | 36 | 34858 | 182574 | 79526920 |
| Myalgia | 15.16 | 12.97 | 37 | 34857 | 185604 | 79523890 |
| Immune reconstitution inflammatory syndrome | 15.11 | 12.97 | 24 | 34870 | 13817 | 79695677 |
| Kussmaul respiration | 15.00 | 12.97 | 6 | 34888 | 421 | 79709073 |
| Eosinophilic pneumonia acute | 14.98 | 12.97 | 8 | 34886 | 1090 | 79708404 |
| Gait disturbance | 14.95 | 12.97 | 44 | 34850 | 207462 | 79502032 |
| Hypoperfusion | 14.95 | 12.97 | 11 | 34883 | 2628 | 79706866 |
| Endotracheal intubation | 14.92 | 12.97 | 14 | 34880 | 4683 | 79704811 |
| Dialysis | 14.89 | 12.97 | 28 | 34866 | 18434 | 79691060 |
| Systemic mycosis | 14.85 | 12.97 | 11 | 34883 | 2655 | 79706839 |
| Morganella infection | 14.79 | 12.97 | 8 | 34886 | 1119 | 79708375 |
| Infusion site induration | 14.73 | 12.97 | 8 | 34886 | 1127 | 79708367 |
| Antibiotic level below therapeutic | 14.66 | 12.97 | 4 | 34890 | 83 | 79709411 |
| Deafness | 14.65 | 12.97 | 30 | 34864 | 21007 | 79688487 |
| Mechanical ventilation | 14.50 | 12.97 | 11 | 34883 | 2753 | 79706741 |
| Spinal subdural haematoma | 14.44 | 12.97 | 5 | 34889 | 234 | 79709260 |
| Clostridial infection | 14.38 | 12.97 | 15 | 34879 | 5699 | 79703795 |
| Haematuria | 14.37 | 12.97 | 64 | 34830 | 68772 | 79640722 |
| Nosocomial infection | 14.26 | 12.97 | 11 | 34883 | 2821 | 79706673 |
| Drug eruption | 14.25 | 12.97 | 47 | 34847 | 43888 | 79665606 |
| Respiratory failure | 14.19 | 12.97 | 131 | 34763 | 180780 | 79528714 |
| Drug ineffective for unapproved indication | 14.18 | 12.97 | 52 | 34842 | 51186 | 79658308 |
| Blood phosphorus decreased | 14.15 | 12.97 | 16 | 34878 | 6652 | 79702842 |
| Corneal deposits | 14.11 | 12.97 | 6 | 34888 | 492 | 79709002 |
| Ejection fraction decreased | 14.03 | 12.97 | 40 | 34854 | 34537 | 79674957 |
| Lung infiltration | 14.03 | 12.97 | 31 | 34863 | 22881 | 79686613 |
| Fixed eruption | 13.85 | 12.97 | 11 | 34883 | 2943 | 79706551 |
| Haemolysis | 13.69 | 12.97 | 22 | 34872 | 12790 | 79696704 |
| Nephropathy | 13.67 | 12.97 | 19 | 34875 | 9719 | 79699775 |
| Sedation | 13.64 | 12.97 | 3 | 34891 | 51892 | 79657602 |
| Pseudomonas infection | 13.62 | 12.97 | 29 | 34865 | 20874 | 79688620 |
| Hyperpyrexia | 13.58 | 12.97 | 15 | 34879 | 6077 | 79703417 |
| VIIIth nerve injury | 13.51 | 12.97 | 3 | 34891 | 25 | 79709469 |
| Pseudomonas test positive | 13.48 | 12.97 | 9 | 34885 | 1843 | 79707651 |
| Auditory neuropathy spectrum disorder | 13.41 | 12.97 | 3 | 34891 | 26 | 79709468 |
| Malnutrition | 13.28 | 12.97 | 30 | 34864 | 22472 | 79687022 |
| Dermatitis bullous | 13.27 | 12.97 | 23 | 34871 | 14222 | 79695272 |
| Status epilepticus | 13.26 | 12.97 | 32 | 34862 | 25009 | 79684485 |
| Gingival swelling | 13.24 | 12.97 | 13 | 34881 | 4596 | 79704898 |
| Coagulation time prolonged | 13.24 | 12.97 | 10 | 34884 | 2485 | 79707009 |
| Retinal toxicity | 13.11 | 12.97 | 8 | 34886 | 1403 | 79708091 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Foetal exposure during pregnancy | 63.65 | 27.04 | 9 | 603 | 12832 | 76348 |
| Drug ineffective | 42.28 | 27.04 | 43 | 569 | 1009 | 88171 |
| Blister | 28.01 | 27.04 | 7 | 605 | 0 | 89180 |
| Source | Code | Description |
|---|---|---|
| ATC | D06AX07 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Other antibiotics for topical use |
| ATC | J01GB03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMINOGLYCOSIDE ANTIBACTERIALS Other aminoglycosides |
| ATC | S01AA11 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
| ATC | S02AA14 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
| ATC | S03AA06 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS ANTIINFECTIVES Antiinfectives |
| FDA CS | M0000946 | Aminoglycosides |
| FDA EPC | N0000175477 | Aminoglycoside Antibacterial |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Septicemia due to Escherichia coli | indication | 9323009 | |
| Bacterial septicemia | indication | 10001005 | DOID:0040085 |
| Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
| Folliculitis | indication | 13600006 | DOID:4409 |
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
| Pneumonia due to Pseudomonas | indication | 41381004 | |
| Peritonitis | indication | 48661000 | |
| Pneumonia due to Escherichia coli | indication | 51530003 | |
| Bacterial pneumonia | indication | 53084003 | DOID:874 |
| Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
| Infection due to Escherichia coli | indication | 71057007 | |
| Bacterial infection due to Serratia | indication | 71120004 | |
| Paronychia | indication | 71906005 | DOID:13117 |
| Rhinoscleroma | indication | 72409005 | DOID:11336 |
| Septicemia due to Serratia | indication | 82091000 | |
| Cholangitis | indication | 82403002 | DOID:9446 |
| Dacryocystitis | indication | 85777005 | DOID:9938 |
| Bacterial meningitis | indication | 95883001 | DOID:9470 |
| Infection of bone | indication | 111253001 | |
| Furunculosis | indication | 112650006 | |
| Infectious disease of abdomen | indication | 128070006 | |
| Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
| Bacterial infection of skin | indication | 128936008 | |
| Infection due to Enterobacteriaceae | indication | 128945009 | |
| Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
| Proteus pneumonia | indication | 195888009 | |
| Sepsis of the newborn | indication | 206376005 | |
| Neonatal pneumonia | indication | 233619008 | |
| Neonatal meningitis | indication | 276674008 | |
| Proteus septicemia | indication | 300986008 | |
| Meibomianitis | indication | 309779001 | |
| Infective blepharitis | indication | 312219000 | |
| Bacterial keratitis | indication | 314557000 | |
| Infectious disorder of joint | indication | 363162000 | |
| Sepsis due to Pseudomonas | indication | 448813005 | |
| Sepsis due to Gram negative bacteria | indication | 449082003 | |
| Skin and Skin Structure Proteus Infection | indication | ||
| Synergy for Staphylococcus Aureus Pneumonia | indication | ||
| Gram-Negative Aerobic Bacillary Pneumonia | indication | ||
| Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
| Enterobacter Pneumonia | indication | ||
| Synergy for Klebsiella Meningitis | indication | ||
| Burn Wound Infections | indication | ||
| Complicated UTI with Pseudomonas Aeruginosa | indication | ||
| Pseudomonas Aeruginosa Osteomyelitis | indication | ||
| Synergy for Proteus Meningitis | indication | ||
| Synergy for Group B Streptococcal Septicemia | indication | ||
| Citrobacter Pneumonia | indication | ||
| Synergy for Staphylococcal Endocarditis | indication | ||
| Synergy for Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
| Synergy for Pseudomonas Aeruginosa Joint Infection | indication | ||
| Pseudomonas Aeruginosa Joint Infection | indication | ||
| Skin and Skin Structure Serratia Infection | indication | ||
| Synergy for Pseudomonas Aeruginosa Osteomyelitis | indication | ||
| Synergy for Neonatal Meningitis | indication | ||
| Pseudomonas Aeruginosa Meningitis | indication | ||
| Synergy for Staphylococcal Joint Infection | indication | ||
| Citrobacter Septicemia | indication | ||
| Pseudomonas Aeruginosa Biliary Tract Infection | indication | ||
| Skin and Skin Structure Citrobacter Infection | indication | ||
| Synergy for Pseudomonas Aeruginosa Pneumonia | indication | ||
| Synergy for Bacterial Meningitis | indication | ||
| Synergy for Staphylococcus Skin and Skin Structure Infection | indication | ||
| Complicated Urinary Tract Infections | indication | ||
| Synergy for Pseudomonas Aeruginosa Meningitis | indication | ||
| Synergy for Staphylococcal Septicemia | indication | ||
| Complicated Bacterial Peritonitis | indication | ||
| Synergy for Staphylococcal Infections | indication | ||
| Synergy for Pseudomonas Aeruginosa Septicemia | indication | ||
| Synergy for Citrobacter Meningitis | indication | ||
| Synergy for Serratia Meningitis | indication | ||
| Synergy for Enterobacter Meningitis | indication | ||
| Klebsiella Septicemia | indication | ||
| Synergy for Escherichia Coli Meningitis | indication | ||
| Necrotizing enterocolitis in fetus OR newborn | off-label use | 2707005 | |
| Pyrexia of unknown origin | off-label use | 7520000 | |
| Ecthyma gangrenosum | off-label use | 17732003 | |
| Enteric campylobacteriosis | off-label use | 18081009 | |
| Pseudotuberculosis | off-label use | 36753006 | |
| Plague | off-label use | 58750007 | DOID:3482 |
| Infection by Yersinia enterocolitica | off-label use | 80960004 | |
| Infection by Campylobacter fetus | off-label use | 111835002 | |
| Listeria Monocytogenes Septicemia | off-label use | ||
| Pseudomonas Respiratory Tract Infection in Cystic Fibrosis | off-label use | ||
| Synergy for Prevention of Enterococcal Endocarditis | off-label use | ||
| Prevention of Perioperative Infection | off-label use | ||
| Synergy for Streptococcal Endocarditis | off-label use | ||
| Synergy for Enterococcal Endocarditis | off-label use | ||
| Synergy for Listeria Monocytogenes Septicemia | off-label use | ||
| Synergy for Enterococcal Infections | off-label use | ||
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Hypocalcemia | contraindication | 5291005 | |
| Herpes simplex keratitis | contraindication | 9389005 | |
| Herpes simplex dendritic keratitis | contraindication | 29943008 | |
| Fungal infection of eye | contraindication | 31194008 | |
| Parkinsonism | contraindication | 32798002 | |
| Dehydration | contraindication | 34095006 | |
| Severe myopia | contraindication | 34187009 | |
| Tuberculosis of eye | contraindication | 49107007 | |
| Tinnitus | contraindication | 60862001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Krukenberg spindle | contraindication | 85430004 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Eye infection | contraindication | 128351009 | |
| Bacterial infection of eye | contraindication | 128984004 | |
| Pregnancy, function | contraindication | 289908002 | |
| Viral eye infection | contraindication | 312132001 | |
| Vaccinia keratitis | contraindication | 397552005 | |
| Vertigo | contraindication | 399153001 | |
| Denuded skin | contraindication | 418242004 | |
| Infant Botulism | contraindication | ||
| Disorder of the 8th Cranial Nerve | contraindication | ||
| Gentamicin Toxicity | contraindication |
| Species | Use | Relation |
|---|---|---|
| Cats | Urinary tract infections | Indication |
| Cats | Respiratory tract infections | Indication |
| Cats | Skin and soft tissue infections | Indication |
| Cats | Supportive therapy for secondary bacterial infections associated with panleucopenia | Indication |
| Cats | Conjunctivitis | Indication |
| Cattle | Infectious bovine keratoconjunctivitis associated with Moraxella bovis | Indication |
| Chickens | Prevention of early mortality caused by Escherichia coli | Indication |
| Chickens | Prevention of early mortality caused by Salmonella typhimurium | Indication |
| Chickens | Prevention of early mortality caused by Pseudomonas aeruginosa | Indication |
| Dogs | External eye infections | Indication |
| Dogs | Acute and chronic otitis externa caused by bacteria | Indication |
| Dogs | Urinary tract infections | Indication |
| Dogs | Respiratory tract infections | Indication |
| Dogs | Skin and soft tissue infections | Indication |
| Horses | Uterus infections | Indication |
| Horses | Improving conception in mares with uterine infections | Indication |
| Swine | Dysentery associated with Brachyspira hyodysenteriae | Indication |
| Swine | PorcinEscherichia colibacillosis caused by Escherichia coli | Indication |
| Turkeys | Prevention of early mortality caused by Arizona paracolon infections | Indication |
| Turkeys | Reduction or elimination of Arizona hinshawii | Indication |
| Turkeys | Reduction or elimination of Salmonella st paul | Indication |
| Turkeys | Reduction or elimination of Mycoplasma meleagris | Indication |
| Product | Applicant | Ingredients |
|---|---|---|
| Gentocin Durafilm | Intervet Inc. | 2 |
| Gentocin Solution | Intervet Inc. | 1 |
| Gentocin Solution | Intervet Inc. | 1 |
| Gentocin Otic Solution | Intervet Inc. | 2 |
| Garacin | Intervet Inc. | 1 |
| Garasol Solution | Intervet Inc. | 1 |
| Gentocin Ophthalmic Ointment | Intervet Inc. | 1 |
| Gentocin Ophthalmic Solution | Intervet Inc. | 1 |
| Garasol Injection | Intervet Inc. | 1 |
| Garacin Piglet Injection | Intervet Inc. | 1 |
| Topagen Ointment | Intervet Inc. | 2 |
| Gentocin (Garacin) Pig Pump Oral Solution | Intervet Inc. | 1 |
| Gentocin Pink Eye Spray | Intervet Inc. | 1 |
| Gentocin Topical Spray | Intervet Inc. | 2 |
| Garacin Soluble Powder | Intervet Inc. | 1 |
| Gentamicin Sulfate Inj. Sol. | Cronus Pharma Specialities India Private Limited | 1 |
| Otomax | Intervet Inc. | 3 |
| Mometamax Otic Suspension | Intervet Inc. | 3 |
| Easotic | Virbac AH Inc. | 3 |
| Gentamicin Sulfate Solution 100 mg/ml | Cronus Pharma Specialities India Private Limited | 1 |
| Gentamicin Sulfate Solution, Legacy Sterile Solution | Huvepharma EOOD | 1 |
| Gentaglyde Solution | Zoetis Inc. | 1 |
| Gentamex 100 | Bimeda Animal Health Limited | 1 |
| GentaMax 100 | Elanco US Inc. | 1 |
| Genta-Ject, Gentamicin Sulfate Injection | Huvepharma EOOD | 1 |
| Gentamicin Sulfate Pig Pump Oral Solution | Huvepharma EOOD | 1 |
| VET BETA-GEN | Med-Pharmex Inc. | 2 |
| GEN-GARD | Huvepharma EOOD | 1 |
| Betagen Topical Spray | Med-Pharmex Inc. | 2 |
| GENTORAL | Med-Pharmex Inc. | 1 |
| Gentasol | Med-Pharmex Inc. | 1 |
| Tri-Otic Ointment | Med-Pharmex Inc. | 3 |
| Vetro-Gen Veterinary Ophthalmic Ointment | Dechra Veterinary Products LLC | 1 |
| Vetro-Max | Fougera Pharmaceuticals Inc. | 3 |
| GBC Ointment | Cronus Pharma Specialities India Private Limited | 3 |
| GB Topical Spray | Dechra Veterinary Products LLC | 2 |
| Gentamicin Piglet Injection | Sparhawk Laboratories Inc. | 1 |
| Gentamicin Sulfate Solution | Sparhawk Laboratories Inc. | 1 |
| Gentamicin Sulfate Topical Spray | First Priority Inc. | 2 |
| Gentamicin Topical Spray | Sparhawk Laboratories Inc. | 2 |
| GentaMed-P for Poultry Injection | Bimeda Animal Health Limited | 1 |
| GentaMed | Bimeda Animal Health Limited | 1 |
| Mometavet | Med-Pharmex Inc. | 3 |
| Gentamicin Sulfate Ophthalmic Solution | Akorn Animal Health Inc. | 1 |
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Dihydrofolate reductase | Enzyme | IC50 | 4.74 | CHEMBL | |||||
| Transient receptor potential cation channel subfamily V member 5 | Ion channel | INHIBITOR | IC50 | 6 | IUPHAR | ||||
| Dihydrofolate reductase | Enzyme | IC50 | 4.60 | CHEMBL | |||||
| Transient receptor potential cation channel subfamily A member 1 | Ion channel | GATING INHIBITOR | IC50 | 5.20 | IUPHAR |
| ID | Source |
|---|---|
| 4019765 | VUID |
| N0000179542 | NUI |
| D01063 | KEGG_DRUG |
| 4018210 | VANDF |
| 4019765 | VANDF |
| C3854019 | UMLSCUI |
| CHEBI:17833 | CHEBI |
| CHEMBL3039597 | ChEMBL_ID |
| CHEMBL463809 | ChEMBL_ID |
| CHEMBL3039594 | ChEMBL_ID |
| D005839 | MESH_DESCRIPTOR_UI |
| DB00798 | DRUGBANK_ID |
| 2427 | IUPHAR_LIGAND_ID |
| 1617 | INN_ID |
| T6Z9V48IKG | UNII |
| 3467 | PUBCHEM_CID |
| 1596450 | RXNORM |
| 228599 | MMSL |
| 4779 | MMSL |
| d00014 | MMSL |
| 002778 | NDDF |
| 004898 | NDDF |
| 2249001 | SNOMEDCT_US |
| 387321007 | SNOMEDCT_US |
| 57752001 | SNOMEDCT_US |
| 1403-66-3 | SECONDARY_CAS_RN |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| PRED-G | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-0066 | OINTMENT | 3 mg | OPHTHALMIC | NDA | 17 sections |
| PRED-G | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-0106 | SUSPENSION/ DROPS | 3 mg | OPHTHALMIC | NDA | 18 sections |
| Gentamicin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9128 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 16 sections |
| Gentamicin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9129 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 16 sections |
| Gentamicin sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0078 | OINTMENT | 1 mg | TOPICAL | ANDA | 10 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0503 | INJECTION, SOLUTION | 80 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0503 | INJECTION, SOLUTION | 80 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0503 | INJECTION, SOLUTION | 80 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0505 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0505 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0505 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0507 | INJECTION, SOLUTION | 60 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0507 | INJECTION, SOLUTION | 60 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0507 | INJECTION, SOLUTION | 60 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0509 | INJECTION, SOLUTION | 80 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0509 | INJECTION, SOLUTION | 80 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0509 | INJECTION, SOLUTION | 80 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0511 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0511 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate in Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-0511 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | ANDA | 23 sections |
| Gentamicin Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9865 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 12 sections |
| Gentamicin Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9865 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 12 sections |
| Gentamicin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9866 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 13 sections |
| Gentamicin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9866 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 13 sections |
| Gentamicin Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1207 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 17 sections |
| Gentamicin Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1207 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 17 sections |
| Gentamicin Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1207 | INJECTION, SOLUTION | 40 mg | INTRAMUSCULAR | ANDA | 17 sections |
| Gentamicin Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0682 | OINTMENT | 1 mg | TOPICAL | ANDA | 9 sections |
| Gentamicin Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0682 | OINTMENT | 1 mg | TOPICAL | ANDA | 9 sections |
| Gentamicin Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0683 | CREAM | 1 mg | TOPICAL | ANDA | 9 sections |