prednisolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2245 50-24-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisolone
  • prenolone
  • deltahydrocortisone
  • hydroretrocortin
  • hydroretrocortine
  • metacortandralone
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
  • Molecular weight: 360.45
  • Formula: C21H28O5
  • CLOGP: 1.42
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.18
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.22 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 16 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.24 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 82 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.86 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.25 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 21, 1955 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumocystis jirovecii pneumonia 1305.56 9.56 810 241200 16104 63230908
Cytomegalovirus infection 1017.32 9.56 753 241257 20199 63226813
Fatigue 757.21 9.56 1400 240610 886628 62360384
Pain 633.60 9.56 1164 240846 739464 62507548
Sepsis 533.83 9.56 1534 240476 151589 63095423
Product dose omission issue 502.38 9.56 136 241874 234177 63012835
Interstitial lung disease 451.84 9.56 831 241179 61077 63185935
Lymphoproliferative disorder 432.16 9.56 221 241789 2969 63244043
Completed suicide 421.35 9.56 36 241974 145637 63101375
Haemophagocytic lymphohistiocytosis 384.12 9.56 321 241689 10306 63236706
Hepatic function abnormal 381.29 9.56 581 241429 36561 63210451
Bronchopulmonary aspergillosis 369.73 9.56 288 241722 8347 63238665
Epstein-Barr virus infection 367.69 9.56 279 241731 7771 63239241
Abdominal discomfort 358.77 9.56 417 241593 320468 62926544
Posterior reversible encephalopathy syndrome 356.11 9.56 383 241627 16962 63230050
Pancytopenia 304.15 9.56 936 241074 95997 63151015
Post transplant lymphoproliferative disorder 302.32 9.56 206 241804 4825 63242187
Diffuse large B-cell lymphoma 298.57 9.56 229 241781 6483 63240529
Varicella zoster virus infection 298.23 9.56 163 241847 2526 63244486
Multiple organ dysfunction syndrome 297.41 9.56 664 241346 56088 63190924
Product use in unapproved indication 297.27 9.56 1411 240599 177669 63069343
Disseminated intravascular coagulation 285.91 9.56 358 241652 18693 63228319
Thrombotic microangiopathy 282.31 9.56 269 241741 10292 63236720
Injection site pain 274.90 9.56 77 241933 129723 63117289
Renal impairment 272.38 9.56 848 241162 87507 63159505
Nocardiosis 267.98 9.56 137 241873 1839 63245173
Swelling 264.66 9.56 400 241610 274978 62972034
Glossodynia 259.98 9.56 182 241828 178694 63068318
Osteonecrosis 259.23 9.56 389 241621 24141 63222871
Transplant rejection 259.02 9.56 259 241751 10521 63236491
Septic shock 257.00 9.56 693 241317 65936 63181076
Pemphigus 255.27 9.56 196 241814 183530 63063482
Progressive multifocal leukoencephalopathy 255.06 9.56 280 241730 12691 63234321
Hepatitis B 245.63 9.56 163 241847 3649 63243363
Drug hypersensitivity 244.72 9.56 511 241499 310176 62936836
Pyrexia 240.69 9.56 2795 239215 467683 62779329
Epstein-Barr virus associated lymphoproliferative disorder 235.84 9.56 124 241886 1770 63245242
Arthropathy 235.41 9.56 331 241679 234461 63012551
Sinusitis 229.75 9.56 317 241693 226336 63020676
Pneumatosis intestinalis 228.85 9.56 132 241878 2281 63244731
Off label use 223.59 9.56 3708 238302 670754 62576258
Pulmonary tuberculosis 222.90 9.56 164 241846 4353 63242659
Joint swelling 218.17 9.56 589 241421 327077 62919935
Hand deformity 217.83 9.56 173 241837 159284 63087728
Polyomavirus-associated nephropathy 216.03 9.56 116 241894 1732 63245280
Respiratory failure 215.83 9.56 864 241146 100994 63146018
Cytomegalovirus viraemia 209.06 9.56 173 241837 5476 63241536
Headache 206.77 9.56 1490 240520 631751 62615261
Aspergillus infection 204.75 9.56 200 241810 7893 63239119
Cytomegalovirus colitis 204.53 9.56 122 241888 2250 63244762
Hepatitis E 204.23 9.56 103 241907 1341 63245671
Premature delivery 204.08 9.56 393 241617 29888 63217124
Alopecia 201.98 9.56 638 241372 336898 62910114
Kidney transplant rejection 201.64 9.56 151 241859 4120 63242892
Pain in extremity 197.34 9.56 628 241382 330858 62916154
Nausea 196.20 9.56 2200 239810 852271 62394741
Leukopenia 192.14 9.56 690 241320 76600 63170412
Drug intolerance 192.07 9.56 573 241437 308088 62938924
Osteonecrosis of jaw 189.67 9.56 416 241594 34707 63212305
Death 188.52 9.56 761 241249 373620 62873392
Contraindicated product administered 186.84 9.56 340 241670 217308 63029704
Alveolar proteinosis 178.61 9.56 63 241947 302 63246710
Atypical femur fracture 177.23 9.56 154 241856 5218 63241794
Hepatitis B reactivation 175.67 9.56 123 241887 3014 63243998
Blood lactate dehydrogenase increased 173.24 9.56 314 241696 22802 63224210
BK virus infection 170.77 9.56 123 241887 3156 63243856
Disseminated tuberculosis 168.97 9.56 116 241894 2751 63244261
JC virus infection 167.83 9.56 102 241908 1949 63245063
Hypogammaglobulinaemia 166.57 9.56 169 241841 6986 63240026
Liver disorder 161.45 9.56 511 241499 53176 63193836
Cushingoid 161.37 9.56 180 241830 8305 63238707
Anxiety 159.47 9.56 372 241638 217169 63029843
Synovitis 158.62 9.56 294 241716 186624 63060388
Asthenia 157.41 9.56 840 241170 382764 62864248
Strongyloidiasis 156.23 9.56 82 241928 1166 63245846
Peripheral swelling 155.97 9.56 507 241503 265435 62981577
Febrile neutropenia 152.50 9.56 870 241140 117579 63129433
Pneumomediastinum 150.88 9.56 84 241926 1352 63245660
Steroid diabetes 149.81 9.56 81 241929 1227 63245785
Escherichia infection 148.87 9.56 212 241798 12542 63234470
Pneumocystis jirovecii infection 145.61 9.56 83 241927 1401 63245611
Toxicity to various agents 145.23 9.56 471 241539 246779 63000233
Peritonitis 142.76 9.56 244 241766 16910 63230102
Nasopharyngitis 142.74 9.56 494 241516 253763 62993249
Upper respiratory tract inflammation 141.46 9.56 99 241911 2424 63244588
Pneumonia bacterial 140.63 9.56 177 241833 9288 63237724
General physical health deterioration 140.55 9.56 1276 240734 200126 63046886
Discomfort 138.71 9.56 267 241743 167107 63079905
Cytomegalovirus test positive 138.70 9.56 105 241905 2913 63244099
Arthralgia 137.86 9.56 1448 240562 568262 62678750
Systemic lupus erythematosus 137.80 9.56 377 241633 208541 63038471
Overdose 132.22 9.56 146 241864 114932 63132080
Therapeutic product effect decreased 130.89 9.56 344 241666 192843 63054169
Dizziness 130.30 9.56 1032 240978 428893 62818119
Meningitis cryptococcal 129.72 9.56 75 241935 1302 63245710
Hypersensitivity 129.59 9.56 624 241386 292061 62954951
Feeling abnormal 128.91 9.56 230 241780 148162 63098850
Organising pneumonia 128.25 9.56 133 241877 5643 63241369
Chorioretinopathy 127.98 9.56 63 241947 776 63246236
Intentional overdose 126.70 9.56 62 241948 74090 63172922
Infection reactivation 125.60 9.56 70 241940 1129 63245883
Brain abscess 125.54 9.56 86 241924 2032 63244980
Muscle spasms 124.30 9.56 255 241755 155895 63091117
Disease recurrence 123.96 9.56 307 241703 27723 63219289
Mycobacterium chelonae infection 123.94 9.56 53 241957 459 63246553
Pneumonia cytomegaloviral 122.10 9.56 86 241924 2128 63244884
Weight increased 120.14 9.56 548 241462 260244 62986768
Enterocolitis 120.02 9.56 149 241861 7709 63239303
Pneumonia 119.84 9.56 2423 239587 454344 62792668
Weight decreased 119.14 9.56 596 241414 276202 62970810
Mucormycosis 119.11 9.56 94 241916 2777 63244235
Arthritis bacterial 117.61 9.56 134 241876 6329 63240683
Drug abuse 117.43 9.56 65 241945 72453 63174559
Wound 116.56 9.56 283 241727 162980 63084032
Tuberculosis 115.90 9.56 176 241834 11035 63235977
Pruritus 115.89 9.56 854 241156 360599 62886413
Herpes zoster 114.32 9.56 618 241392 81844 63165168
Fall 113.69 9.56 953 241057 391381 62855631
Hypotension 113.34 9.56 594 241416 272010 62975002
Anti-cyclic citrullinated peptide antibody positive 112.25 9.56 168 241842 116044 63130968
Bone marrow failure 112.23 9.56 304 241706 28986 63218026
Depression 112.11 9.56 379 241631 196113 63050899
Hospitalisation 111.56 9.56 96 241914 84985 63162027
Cerebral infarction 111.31 9.56 267 241743 23626 63223386
Therapy partial responder 111.14 9.56 168 241842 10490 63236522
Pleurisy 109.91 9.56 147 241863 8193 63238819
Gamma-glutamyltransferase increased 109.80 9.56 332 241678 33699 63213313
Wrong technique in product usage process 109.77 9.56 50 241960 62290 63184722
Immunosuppressant drug level increased 109.47 9.56 99 241911 3539 63243473
Polyomavirus viraemia 108.65 9.56 54 241956 680 63246332
Platelet count decreased 107.63 9.56 785 241225 115337 63131675
Insomnia 106.62 9.56 440 241570 214812 63032200
Injection site erythema 105.27 9.56 97 241913 83077 63163935
Pneumonia cryptococcal 104.44 9.56 54 241956 743 63246269
Cytomegalovirus infection reactivation 104.13 9.56 100 241910 3863 63243149
Oesophageal candidiasis 104.04 9.56 118 241892 5545 63241467
Premature baby 103.45 9.56 238 241772 20497 63226515
Adult T-cell lymphoma/leukaemia 103.15 9.56 37 241973 188 63246824
Lupus nephritis 103.09 9.56 86 241924 2753 63244259
Injection site reaction 102.95 9.56 47 241963 58477 63188535
Agranulocytosis 102.52 9.56 267 241743 24867 63222145
Complications of transplanted kidney 102.29 9.56 81 241929 2405 63244607
Staphylococcal sepsis 102.16 9.56 140 241870 7988 63239024
Exposure during pregnancy 100.68 9.56 970 241040 154577 63092435
Nasal congestion 100.45 9.56 63 241947 65597 63181415
Nephrotic syndrome 100.43 9.56 115 241895 5461 63241551
Acute respiratory distress syndrome 100.12 9.56 254 241756 23280 63223732
Alanine aminotransferase increased 99.34 9.56 707 241303 103063 63143949
Pseudomonas infection 99.30 9.56 164 241846 11049 63235963
Haemolytic anaemia 99.12 9.56 155 241855 9970 63237042
Blood pressure increased 99.12 9.56 303 241707 161759 63085253
Central nervous system lymphoma 98.65 9.56 65 241945 1437 63245575
Low birth weight baby 97.56 9.56 128 241882 7001 63240011
Epstein Barr virus positive mucocutaneous ulcer 97.52 9.56 43 241967 404 63246608
Scleroderma renal crisis 95.07 9.56 39 241971 301 63246711
Psoriasis 94.83 9.56 115 241895 86842 63160170
Rebound effect 94.75 9.56 101 241909 4425 63242587
Vasculitis 94.16 9.56 212 241798 17997 63229015
Stress 94.04 9.56 71 241939 67096 63179916
C-reactive protein increased 94.02 9.56 651 241359 94056 63152956
Viraemia 93.92 9.56 60 241950 1256 63245756
Pulmonary nocardiosis 93.23 9.56 39 241971 318 63246694
Thrombocytopenia 92.65 9.56 932 241078 150225 63096787
Aspartate aminotransferase increased 92.26 9.56 625 241385 89652 63157360
Lymphopenia 92.13 9.56 211 241799 18116 63228896
Herpes simplex 91.44 9.56 134 241876 8137 63238875
Hepatic enzyme increased 90.86 9.56 429 241581 201899 63045113
Musculoskeletal stiffness 90.40 9.56 379 241631 184239 63062773
Toxic epidermal necrolysis 90.20 9.56 256 241754 25078 63221934
Gastroenteritis 90.14 9.56 264 241746 26326 63220686
Sedation 89.97 9.56 19 241991 38790 63208222
Gait disturbance 87.26 9.56 380 241630 182798 63064214
Proteinuria 87.10 9.56 212 241798 18933 63228079
Inappropriate schedule of product administration 86.83 9.56 165 241845 103800 63143212
Liver transplant rejection 86.79 9.56 59 241951 1376 63245636
Renal phospholipidosis 86.61 9.56 27 241983 80 63246932
Injection site bruising 86.59 9.56 26 241984 41884 63205128
Balance disorder 86.51 9.56 117 241893 84305 63162707
Cerebral toxoplasmosis 86.15 9.56 51 241959 927 63246085
Confusional state 85.87 9.56 538 241472 235842 63011170
Diffuse large B-cell lymphoma recurrent 85.74 9.56 71 241939 2249 63244763
Gestational diabetes 85.65 9.56 131 241879 8265 63238747
Back pain 84.62 9.56 624 241386 263521 62983491
Cardiac failure 84.54 9.56 606 241404 88536 63158476
Migraine 83.73 9.56 167 241843 103179 63143833
COVID-19 83.66 9.56 726 241284 112377 63134635
Angiocentric lymphoma 83.40 9.56 43 241967 588 63246424
Cytomegalovirus enterocolitis 83.13 9.56 44 241966 637 63246375
Drug eruption 82.51 9.56 269 241741 28425 63218587
Cytomegalovirus chorioretinitis 81.56 9.56 62 241948 1731 63245281
Listeriosis 81.38 9.56 58 241952 1463 63245549
Eosinophilic granulomatosis with polyangiitis 80.84 9.56 67 241943 2125 63244887
Lymphoma 80.67 9.56 157 241853 12030 63234982
Atypical mycobacterial infection 80.62 9.56 51 241959 1049 63245963
Large intestine perforation 80.48 9.56 128 241882 8354 63238658
Substance-induced psychotic disorder 79.05 9.56 63 241947 1888 63245124
Bacteraemia 77.75 9.56 191 241819 17157 63229855
Myopathy 77.55 9.56 147 241863 11044 63235968
Blood pressure fluctuation 77.20 9.56 40 241970 46277 63200735
Cytomegalovirus enteritis 76.70 9.56 32 241978 259 63246753
Pleural effusion 76.22 9.56 612 241398 92598 63154414
Symptom masked 75.95 9.56 43 241967 716 63246296
Pyelonephritis 75.75 9.56 192 241818 17586 63229426
Adrenal suppression 75.73 9.56 46 241964 878 63246134
Klebsiella infection 75.47 9.56 125 241885 8441 63238571
Drug ineffective for unapproved indication 75.36 9.56 293 241717 33770 63213242
Hypofibrinogenaemia 75.31 9.56 50 241960 1120 63245892
Infusion related reaction 74.85 9.56 588 241422 244933 63002079
Infectious pleural effusion 74.80 9.56 56 241954 1527 63245485
Constipation 74.15 9.56 527 241483 224416 63022596
Parvovirus B19 infection 73.68 9.56 38 241972 520 63246492
Injection site pruritus 73.67 9.56 40 241970 45076 63201936
Spinal compression fracture 73.53 9.56 166 241844 14117 63232895
Encephalitis 73.48 9.56 126 241884 8754 63238258
Cryptococcosis 73.40 9.56 49 241961 1108 63245904
Irritable bowel syndrome 73.11 9.56 126 241884 82286 63164726
Contusion 72.22 9.56 310 241700 149734 63097278
Hyperglycaemia 71.59 9.56 333 241677 41534 63205478
Injection site swelling 70.91 9.56 47 241963 47525 63199487
Mental status changes 70.90 9.56 31 241979 39568 63207444
Immunosuppression 70.24 9.56 123 241887 8691 63238321
Diabetes mellitus 69.86 9.56 407 241603 55403 63191609
Unevaluable event 69.80 9.56 56 241954 51330 63195682
Pericarditis 69.54 9.56 262 241748 131317 63115695
Product use issue 69.15 9.56 524 241486 219996 63027016
Cerebrovascular accident 68.89 9.56 198 241812 107826 63139186
Urosepsis 68.71 9.56 190 241820 18334 63228678
Mycobacterium marinum infection 68.64 9.56 29 241981 243 63246769
Illness 68.49 9.56 52 241958 49007 63198005
Neutropenic sepsis 68.45 9.56 176 241834 16262 63230750
Therapy cessation 68.41 9.56 16 241994 30441 63216571
Diarrhoea 68.23 9.56 2143 239867 713223 62533789
Chronic graft versus host disease 68.10 9.56 71 241939 3031 63243981
Osteoporosis 67.83 9.56 412 241598 56926 63190086
Heart rate increased 67.50 9.56 163 241847 94075 63152937
Mycobacterium abscessus infection 67.47 9.56 38 241972 626 63246386
Disseminated cryptococcosis 67.36 9.56 33 241977 402 63246610
Enterococcal infection 67.11 9.56 113 241897 7735 63239277
Multiple sclerosis relapse 66.89 9.56 52 241958 48426 63198586
Blood beta-D-glucan increased 66.76 9.56 27 241983 200 63246812
Electrocardiogram QT prolonged 66.75 9.56 77 241933 59453 63187559
Adrenal insufficiency 66.70 9.56 184 241826 17731 63229281
Steroid withdrawal syndrome 65.93 9.56 35 241975 510 63246502
Cardiac failure congestive 65.32 9.56 161 241849 92272 63154740
Blood pressure systolic increased 65.20 9.56 51 241959 47346 63199666
Neutropenia 65.00 9.56 982 241028 174023 63072989
Tuberculous pleurisy 64.80 9.56 32 241978 397 63246615
Mycobacterium avium complex infection 64.80 9.56 69 241941 3019 63243993
Mycobacterial infection 64.72 9.56 54 241956 1729 63245283
Staphylococcal infection 64.65 9.56 320 241690 40936 63206076
Subarachnoid haemorrhage 63.74 9.56 157 241853 14126 63232886
Pneumothorax 63.52 9.56 170 241840 16091 63230921
Drug resistance 63.26 9.56 212 241798 22721 63224291
Product quality issue 62.77 9.56 29 241981 35836 63211176
Gastrooesophageal reflux disease 62.68 9.56 173 241837 95466 63151546
Rhinorrhoea 62.15 9.56 96 241914 65481 63181531
Rheumatoid factor positive 62.04 9.56 144 241866 84262 63162750
Therapy interrupted 62.04 9.56 23 241987 32432 63214580
Hepatic failure 61.99 9.56 285 241725 35371 63211641
Suicide attempt 61.83 9.56 85 241925 60833 63186179
Tendon rupture 61.83 9.56 112 241898 8127 63238885
Gastric ulcer 61.75 9.56 217 241793 23820 63223192
Nephropathy toxic 61.39 9.56 121 241889 9358 63237654
Device dislocation 60.80 9.56 12 241998 25693 63221319
Incorrect dose administered 60.54 9.56 84 241926 59884 63187128
Bacterial sepsis 60.37 9.56 75 241935 3883 63243129
Myelodysplastic syndrome 59.35 9.56 169 241841 16585 63230427
Skin ulcer 59.22 9.56 322 241688 42723 63204289
Device issue 58.62 9.56 10 242000 23771 63223241
Premature labour 58.53 9.56 140 241870 12364 63234648
Foetal growth restriction 58.37 9.56 104 241906 7449 63239563
Subcutaneous emphysema 58.15 9.56 38 241972 828 63246184
Necrotising retinitis 57.13 9.56 29 241981 383 63246629
Liver abscess 56.78 9.56 62 241948 2792 63244220
Foetal exposure during pregnancy 56.70 9.56 257 241753 31705 63215307
Adenovirus infection 56.62 9.56 69 241941 3502 63243510
Splenic abscess 56.32 9.56 22 241988 147 63246865
Aplasia pure red cell 55.96 9.56 77 241933 4410 63242602
Phaeohyphomycosis 55.80 9.56 26 241984 281 63246731
Suicidal ideation 55.76 9.56 95 241915 62326 63184686
Serotonin syndrome 55.38 9.56 20 241990 28662 63218350
Pneumoperitoneum 55.09 9.56 45 241965 1398 63245614
Malignant neoplasm of conjunctiva 55.07 9.56 16 241994 34 63246978
Hypoalbuminaemia 55.07 9.56 132 241878 11673 63235339
Somnolence 54.40 9.56 428 241582 178257 63068755
Lymphocytic infiltration 54.05 9.56 37 241973 873 63246139
Osteoporotic fracture 53.98 9.56 69 241941 3677 63243335
Listeria sepsis 53.67 9.56 34 241976 701 63246311
Necrotising fasciitis 53.56 9.56 62 241948 2979 63244033
Enteritis infectious 52.81 9.56 52 241958 2072 63244940
Neck pain 52.78 9.56 116 241894 69202 63177810
Rash 52.45 9.56 1684 240326 559187 62687825
Lung infiltration 52.32 9.56 147 241863 14316 63232696
Normal newborn 52.25 9.56 105 241905 8236 63238776
Full blood count decreased 52.23 9.56 17 241993 26007 63221005
Immunosuppressant drug level decreased 52.16 9.56 37 241973 926 63246086
Graft versus host disease 52.11 9.56 93 241917 6670 63240342
Red blood cell sedimentation rate abnormal 51.78 9.56 7 242003 19775 63227237
Infection in an immunocompromised host 51.48 9.56 33 241977 695 63246317
Muscle abscess 51.32 9.56 26 241984 342 63246670
Heart rate decreased 51.00 9.56 59 241951 45501 63201511
Oral candidiasis 50.34 9.56 196 241814 22602 63224410
Ear infection 50.22 9.56 43 241967 38170 63208842
Altered state of consciousness 50.20 9.56 210 241800 25020 63221992
Pneumonitis 50.16 9.56 266 241744 34956 63212056
Placenta accreta 50.15 9.56 22 241988 204 63246808
Endocarditis 49.44 9.56 83 241927 5667 63241345
Iron deficiency anaemia 49.35 9.56 178 241832 19791 63227221
Sinus disorder 49.34 9.56 16 241994 24537 63222475
Full blood count abnormal 49.10 9.56 30 241980 31687 63215325
Cholangitis 48.79 9.56 81 241929 5480 63241532
Meningitis bacterial 48.79 9.56 41 241969 1326 63245686
Epstein-Barr virus infection reactivation 48.72 9.56 33 241977 765 63246247
Fluid retention 48.72 9.56 96 241914 59590 63187422
Burning sensation 48.41 9.56 83 241927 54324 63192688
Nervousness 48.38 9.56 29 241981 30950 63216062
Viral vasculitis 47.98 9.56 15 241995 45 63246967
Obliterative bronchiolitis 47.88 9.56 49 241961 2046 63244966
Endocarditis bacterial 47.64 9.56 30 241980 612 63246400
Muscle injury 47.60 9.56 112 241898 65233 63181779
Opportunistic infection 47.54 9.56 47 241963 1882 63245130
Angiosarcoma 47.44 9.56 22 241988 235 63246777
Systemic candida 47.12 9.56 60 241950 3185 63243827
Macular degeneration 47.06 9.56 17 241993 24359 63222653
Memory impairment 46.79 9.56 221 241789 104037 63142975
Acute graft versus host disease 46.46 9.56 70 241940 4358 63242654
Diffuse large B-cell lymphoma refractory 46.20 9.56 38 241972 1192 63245820
Intentional self-injury 46.16 9.56 20 241990 25667 63221345
Splenomegaly 45.99 9.56 119 241891 11038 63235974
Escherichia bacteraemia 45.99 9.56 65 241945 3818 63243194
Pancreatic steatosis 45.92 9.56 35 241975 981 63246031
Treatment failure 45.87 9.56 511 241499 198532 63048480
Bradycardia 45.39 9.56 136 241874 73091 63173921
Secondary adrenocortical insufficiency 45.23 9.56 40 241970 1388 63245624
Injection site haemorrhage 45.19 9.56 18 241992 24296 63222716
Accidental exposure to product 45.18 9.56 24 241986 27381 63219631
Cerebral haemorrhage 45.09 9.56 234 241776 30495 63216517
Ill-defined disorder 45.02 9.56 160 241850 81595 63165417
Systemic mycosis 45.01 9.56 37 241973 1160 63245852
Joint stiffness 44.97 9.56 56 241954 41813 63205199
Multiple-drug resistance 44.95 9.56 75 241935 5095 63241917
Pyoderma gangrenosum 44.90 9.56 62 241948 3563 63243449
Malacoplakia 44.79 9.56 19 241991 161 63246851
Secondary immunodeficiency 44.32 9.56 39 241971 1344 63245668
Haemolytic uraemic syndrome 44.03 9.56 51 241959 2452 63244560
Pyelonephritis acute 43.98 9.56 70 241940 4571 63242441
Disseminated trichosporonosis 43.93 9.56 15 241995 64 63246948
Herpes zoster meningitis 43.56 9.56 15 241995 66 63246946
Transplant failure 43.55 9.56 41 241969 1544 63245468
Emotional distress 43.54 9.56 36 241974 32513 63214499
Scedosporium infection 43.52 9.56 27 241983 536 63246476
Human T-cell lymphotropic virus type I infection 43.38 9.56 14 241996 48 63246964
Shock 43.38 9.56 191 241819 23272 63223740
Retinal detachment 43.35 9.56 80 241930 5889 63241123
Neuropsychiatric lupus 43.33 9.56 19 241991 176 63246836
Lung abscess 43.26 9.56 44 241966 1824 63245188
Subcutaneous abscess 43.18 9.56 77 241933 5519 63241493
Erysipelas 43.08 9.56 94 241916 7811 63239201
Cytomegalovirus hepatitis 42.85 9.56 23 241987 343 63246669
Premature rupture of membranes 42.84 9.56 72 241938 4921 63242091
Dyspepsia 42.78 9.56 222 241788 101974 63145038
Inflammatory marker increased 42.73 9.56 86 241924 6753 63240259
Acute graft versus host disease in skin 42.69 9.56 59 241951 3393 63243619
Lemierre syndrome 42.69 9.56 16 241994 94 63246918
Eczema herpeticum 42.59 9.56 18 241992 151 63246861
Systemic infection 42.40 9.56 69 241941 4591 63242421
Central obesity 42.30 9.56 36 241974 1185 63245827
Influenza like illness 42.22 9.56 123 241887 66701 63180311
Pancreatitis acute 42.05 9.56 210 241800 26956 63220056
Hot flush 42.00 9.56 82 241928 51077 63195935
Pulmonary embolism 41.85 9.56 651 241359 116033 63130979
Chronic allograft nephropathy 41.83 9.56 29 241981 699 63246313
Injection site mass 41.50 9.56 10 242000 18646 63228366
Maternal exposure during pregnancy 41.32 9.56 1115 240895 218947 63028065
Sedation complication 41.10 9.56 3 242007 13819 63233193
Duodenal ulcer 40.88 9.56 91 241919 7665 63239347
Interleukin-2 receptor increased 40.77 9.56 15 241995 83 63246929
Bone tuberculosis 40.72 9.56 19 241991 206 63246806
Paraesthesia 40.65 9.56 392 241618 156574 63090438
Tremor 40.58 9.56 316 241694 131923 63115089
Erythema multiforme 40.42 9.56 107 241903 10062 63236950
Ascites 40.41 9.56 280 241730 40448 63206564
Intraocular pressure increased 39.86 9.56 78 241932 6000 63241012
Escherichia urinary tract infection 39.81 9.56 118 241892 11844 63235168
Blood glucose decreased 39.79 9.56 15 241995 20937 63226075
Infusion site pain 39.64 9.56 8 242002 16861 63230151
Meningitis listeria 39.63 9.56 27 241983 632 63246380
Cardiac disorder 39.55 9.56 84 241926 50732 63196280
Heart rate irregular 39.44 9.56 18 241992 22403 63224609
Kaposi's sarcoma 39.38 9.56 17 241993 151 63246861
Atypical haemolytic uraemic syndrome 39.26 9.56 28 241982 707 63246305
Crying 39.14 9.56 20 241990 23323 63223689
Central nervous system vasculitis 39.07 9.56 31 241979 923 63246089
Jaundice 39.02 9.56 217 241793 29034 63217978
Circulatory collapse 38.61 9.56 176 241834 21762 63225250
Musculoskeletal chest pain 38.55 9.56 16 241994 21067 63225945
Ocular hypertension 38.53 9.56 32 241978 1018 63245994
Haemorrhage subcutaneous 38.43 9.56 52 241958 2931 63244081
Renal transplant failure 38.35 9.56 28 241982 734 63246278
Empyema 38.16 9.56 43 241967 2006 63245006
Neuropathy peripheral 38.05 9.56 265 241745 113402 63133610
Varicella zoster pneumonia 37.90 9.56 12 241998 38 63246974
Blood glucose increased 37.90 9.56 177 241833 83579 63163433
Immune thrombocytopenia 37.90 9.56 107 241903 10449 63236563
Loss of personal independence in daily activities 37.61 9.56 217 241793 97073 63149939
Trichophytosis 37.61 9.56 13 241997 58 63246954
Adrenal atrophy 37.36 9.56 11 241999 25 63246987
Anaemia 37.36 9.56 1419 240591 292011 62955001
Femoral neck fracture 37.31 9.56 93 241917 8430 63238582
Diverticular perforation 37.17 9.56 56 241954 3486 63243526
Arterial haemorrhage 37.16 9.56 39 241971 1678 63245334
White blood cell count increased 37.08 9.56 314 241696 48247 63198765
Leukoencephalopathy 37.02 9.56 63 241947 4350 63242662
Aortic dissection 36.99 9.56 42 241968 1976 63245036
Foetal methotrexate syndrome 36.99 9.56 15 241995 112 63246900
Feeling jittery 36.91 9.56 4 242006 13399 63233613
Procedural pain 36.88 9.56 18 241992 21551 63225461
Blood pressure systolic abnormal 36.85 9.56 4 242006 13382 63233630
Unresponsive to stimuli 36.56 9.56 45 241965 33771 63213241
Surgery 36.55 9.56 50 241960 35862 63211150
Dry eye 36.43 9.56 62 241948 40699 63206313
Drug interaction 36.43 9.56 1137 240873 227994 63019018
Intussusception 36.41 9.56 25 241985 593 63246419
Concomitant disease aggravated 36.34 9.56 96 241914 9016 63237996
Acute abdomen 36.33 9.56 37 241973 1536 63245476
Cystitis haemorrhagic 36.10 9.56 60 241950 4063 63242949
Visceral leishmaniasis 36.09 9.56 24 241986 539 63246473
Mycotic endophthalmitis 36.09 9.56 13 241997 67 63246945
Sinus congestion 36.08 9.56 12 241998 18111 63228901
Bronchiectasis 35.82 9.56 139 241871 16003 63231009
Bedridden 35.82 9.56 108 241902 10943 63236069
Antiphospholipid syndrome 35.81 9.56 39 241971 1751 63245261
Small intestinal perforation 35.66 9.56 36 241974 1479 63245533
Hypoaesthesia 35.06 9.56 442 241568 167951 63079061
Throat irritation 34.82 9.56 56 241954 37591 63209421
Neuroleptic malignant syndrome 34.77 9.56 3 242007 12053 63234959
Bacterial infection 34.74 9.56 157 241853 19342 63227670
Folliculitis 34.60 9.56 144 241866 70173 63176839
Hepatitis 34.58 9.56 265 241745 39523 63207489
Coombs positive haemolytic anaemia 34.40 9.56 20 241990 351 63246661
Limb reduction defect 34.38 9.56 21 241989 405 63246607
Transaminases increased 34.35 9.56 221 241789 31146 63215866
Synovectomy 34.25 9.56 16 241994 174 63246838
Disseminated varicella zoster virus infection 34.10 9.56 18 241992 259 63246753
Drug withdrawal syndrome 34.06 9.56 32 241978 27162 63219850
Tachyarrhythmia 34.04 9.56 61 241949 4389 63242623
Adrenocortical insufficiency acute 33.98 9.56 37 241973 1661 63245351
Melaena 33.90 9.56 215 241795 30150 63216862
Auditory neuropathy spectrum disorder 33.88 9.56 10 242000 23 63246989
Intentional product misuse 33.68 9.56 119 241891 60798 63186214
Cognitive disorder 33.63 9.56 105 241905 55710 63191302
Polyneuropathy 33.50 9.56 127 241883 14462 63232550
Colon cancer 33.40 9.56 98 241912 9780 63237232
Product monitoring error 33.39 9.56 61 241949 4455 63242557
Lymphadenopathy 33.34 9.56 256 241754 38202 63208810
Paroxysmal extreme pain disorder 33.26 9.56 13 241997 87 63246925
Injection site rash 33.24 9.56 15 241995 18794 63228218
Helicobacter infection 33.22 9.56 212 241798 92573 63154439
Cardiac valve vegetation 33.16 9.56 18 241992 275 63246737
Tubulointerstitial nephritis 33.06 9.56 157 241853 19746 63227266
Primary biliary cholangitis 32.92 9.56 31 241979 1168 63245844
Anogenital warts 32.90 9.56 22 241988 499 63246513
Ecthyma 32.87 9.56 18 241992 280 63246732
Arthritis 32.83 9.56 283 241727 115638 63131374
Lymph node tuberculosis 32.80 9.56 26 241984 773 63246239
Gastrointestinal disorder 32.61 9.56 331 241679 130908 63116104
Blood creatinine increased 32.61 9.56 493 241517 87351 63159661
Abscess 32.59 9.56 138 241872 16530 63230482
Restless legs syndrome 32.40 9.56 15 241995 18516 63228496
Graft versus host disease in gastrointestinal tract 32.26 9.56 50 241960 3191 63243821
Hepatitis viral 32.20 9.56 21 241989 456 63246556
Pneumonia fungal 32.19 9.56 67 241943 5388 63241624
Tumour lysis syndrome 32.15 9.56 91 241919 8899 63238113
Meningitis 32.14 9.56 79 241931 7098 63239914
Enterococcal sepsis 32.11 9.56 33 241977 1385 63245627
Panniculitis 32.07 9.56 106 241904 11279 63235733
Rheumatoid arthritis 32.00 9.56 730 241280 253089 62993923
Blood immunoglobulin G decreased 31.89 9.56 43 241967 2415 63244597
Heart transplant rejection 31.87 9.56 23 241987 592 63246420
Growth retardation 31.81 9.56 32 241978 1309 63245703
Graft loss 31.68 9.56 19 241991 354 63246658
Infective exacerbation of chronic obstructive airways disease 31.67 9.56 31 241979 1226 63245786
Encephalitis viral 31.67 9.56 36 241974 1696 63245316
Synostosis 31.66 9.56 11 241999 50 63246962
Sleep disorder due to general medical condition, insomnia type 31.63 9.56 98 241912 52119 63194893
Gastritis haemorrhagic 31.50 9.56 34 241976 1511 63245501
IIIrd nerve paralysis 31.45 9.56 24 241986 674 63246338
Neisseria infection 31.40 9.56 13 241997 103 63246909
Escherichia sepsis 31.32 9.56 63 241947 4944 63242068
Transplant dysfunction 31.32 9.56 62 241948 4810 63242202
Sleep apnoea syndrome 31.25 9.56 39 241971 29094 63217918
Poisoning 31.16 9.56 7 242003 13693 63233319
Thyroiditis subacute 31.07 9.56 17 241993 264 63246748
Tonsillitis 31.03 9.56 68 241942 5667 63241345
Anaphylactoid reaction 31.03 9.56 53 241957 3670 63243342
Intervertebral discitis 31.02 9.56 49 241961 3179 63243833
Hydronephrosis 30.69 9.56 100 241910 10562 63236450
Loss of consciousness 30.57 9.56 295 241715 117826 63129186
Nephrolithiasis 30.54 9.56 72 241938 41912 63205100
Hypopyon 30.44 9.56 24 241986 708 63246304
Injection site urticaria 30.43 9.56 8 242002 14065 63232947
Neonatal hypoacusis 30.41 9.56 9 242001 21 63246991
Injection site warmth 30.36 9.56 10 242000 15185 63231827
Meningitis tuberculous 30.32 9.56 22 241988 571 63246441
Central nervous system fungal infection 29.97 9.56 13 241997 117 63246895
B-cell lymphoma recurrent 29.90 9.56 19 241991 394 63246618
Talipes 29.85 9.56 33 241977 1507 63245505
Cytomegalovirus gastroenteritis 29.76 9.56 15 241995 195 63246817
Systemic inflammatory response syndrome 29.68 9.56 66 241944 5555 63241457
Cutaneous nocardiosis 29.56 9.56 9 242001 24 63246988
Seizure 29.56 9.56 343 241667 132291 63114721
Thymoma 29.56 9.56 15 241995 198 63246814
Lupus pancreatitis 29.53 9.56 7 242003 3 63247009
Dysgeusia 29.48 9.56 86 241924 46624 63200388
Anuria 29.43 9.56 110 241900 12441 63234571
Stevens-Johnson syndrome 29.32 9.56 179 241831 24771 63222241
Colitis ulcerative 29.29 9.56 185 241825 25906 63221106
Degenerative bone disease 29.28 9.56 14 241996 161 63246851
Lower limb fracture 29.25 9.56 175 241835 24046 63222966
Humoral immune defect 29.21 9.56 16 241994 249 63246763
Tooth infection 29.09 9.56 16 241994 17904 63229108
Dehydration 29.06 9.56 475 241535 172879 63074133
Alveolitis 29.06 9.56 45 241965 2870 63244142
Gallbladder disorder 28.92 9.56 18 241992 18824 63228188
Osteomyelitis 28.90 9.56 184 241826 25836 63221176
Herpes simplex reactivation 28.88 9.56 21 241989 547 63246465
Substance-induced mood disorder 28.87 9.56 7 242003 4 63247008
Tooth disorder 28.86 9.56 39 241971 28118 63218894
Psoas abscess 28.81 9.56 20 241990 483 63246529
Flushing 28.74 9.56 168 241842 74919 63172093
Retinitis viral 28.68 9.56 10 242000 46 63246966
Gallbladder rupture 28.52 9.56 19 241991 428 63246584
Gastric ulcer perforation 28.41 9.56 29 241981 1207 63245805
Passenger lymphocyte syndrome 28.35 9.56 11 241999 72 63246940
Dry skin 28.30 9.56 116 241894 56771 63190241
Joint injury 28.29 9.56 43 241967 29529 63217483
Herpes simplex viraemia 28.24 9.56 17 241993 319 63246693
Paraneoplastic pemphigus 28.22 9.56 11 241999 73 63246939
Lumbar vertebral fracture 28.22 9.56 66 241944 5744 63241268
Chronic respiratory disease 28.19 9.56 14 241996 176 63246836
Blood pressure diastolic decreased 28.11 9.56 27 241983 22679 63224333
Gastroenteritis clostridial 28.10 9.56 21 241989 571 63246441
Hypersomnia 28.06 9.56 17 241993 18038 63228974
Dermatophytosis 28.05 9.56 14 241996 178 63246834
Psoriatic arthropathy 27.93 9.56 219 241791 91301 63155711
Infection masked 27.86 9.56 9 242001 31 63246981
Diverticulum intestinal haemorrhagic 27.79 9.56 32 241978 1529 63245483
Pneumonia haemophilus 27.79 9.56 22 241988 653 63246359
Type 1 diabetes mellitus 27.78 9.56 51 241959 3739 63243273
T-cell lymphoma 27.76 9.56 22 241988 654 63246358
Cutaneous tuberculosis 27.54 9.56 13 241997 145 63246867
Microsporidia infection 27.51 9.56 16 241994 281 63246731
Pre-eclampsia 27.50 9.56 87 241923 9046 63237966
Respiratory tract congestion 27.42 9.56 17 241993 17815 63229197
Oligohydramnios 27.38 9.56 69 241941 6297 63240715
Symblepharon 27.37 9.56 11 241999 80 63246932
Gastritis 27.32 9.56 239 241771 37064 63209948
Jaw operation 27.25 9.56 24 241986 828 63246184
Human herpesvirus 6 infection 27.20 9.56 44 241966 2913 63244099
Rheumatoid vasculitis 27.16 9.56 17 241993 343 63246669
Anal prolapse 27.14 9.56 11 241999 82 63246930
Polyomavirus test positive 27.14 9.56 11 241999 82 63246930
Diverticulum intestinal 27.05 9.56 71 241939 6642 63240370
HIV infection 27.04 9.56 18 241992 405 63246607
Oxygen saturation decreased 27.02 9.56 212 241798 88373 63158639
Neuromyelitis optica spectrum disorder 26.99 9.56 26 241984 1008 63246004
Cloacal exstrophy 26.93 9.56 13 241997 153 63246859
Small for dates baby 26.90 9.56 50 241960 3701 63243311
Confusional arousal 26.86 9.56 14 241996 196 63246816
Laboratory test abnormal 26.86 9.56 38 241972 26874 63220138
Encephalitis cytomegalovirus 26.85 9.56 20 241990 541 63246471
Bursitis infective staphylococcal 26.81 9.56 9 242001 36 63246976
Bronchiolitis 26.81 9.56 42 241968 2705 63244307
Influenza 26.68 9.56 275 241735 108447 63138565
Wound infection pseudomonas 26.68 9.56 29 241981 1299 63245713
Carpal tunnel syndrome 26.66 9.56 24 241986 20793 63226219
Cytopenia 26.65 9.56 101 241909 11500 63235512
Listeria encephalitis 26.53 9.56 15 241995 249 63246763
Dyskinesia 26.52 9.56 51 241959 31951 63215061
Reversible cerebral vasoconstriction syndrome 26.45 9.56 41 241969 2617 63244395
Gastrointestinal amyloidosis 26.37 9.56 10 242000 61 63246951
Aortic valve stenosis 26.24 9.56 46 241964 3253 63243759
Immune reconstitution inflammatory syndrome 26.22 9.56 66 241944 6018 63240994
Lymphocele 26.10 9.56 23 241987 794 63246218
Purpura 26.05 9.56 99 241911 11286 63235726
Lymphocyte stimulation test positive 25.96 9.56 19 241991 500 63246512
Bronchopleural fistula 25.95 9.56 14 241996 211 63246801
Myelopathy 25.92 9.56 42 241968 2784 63244228
Sleep disorder 25.92 9.56 193 241817 81373 63165639
Endophthalmitis 25.91 9.56 48 241962 3544 63243468
Abscess bacterial 25.90 9.56 14 241996 212 63246800
Cell marker increased 25.86 9.56 15 241995 262 63246750
Sneezing 25.82 9.56 19 241991 18199 63228813
Ileus paralytic 25.81 9.56 55 241955 4496 63242516
B-cell lymphoma refractory 25.75 9.56 11 241999 95 63246917
Bone erosion 25.74 9.56 18 241992 17699 63229313
Intestinal perforation 25.72 9.56 102 241908 11861 63235151
Pseudarthrosis 25.71 9.56 18 241992 441 63246571
Hernia 25.61 9.56 8 242002 12566 63234446
Atrial septal defect 25.57 9.56 71 241939 6867 63240145
Gastrointestinal disorder congenital 25.57 9.56 12 241998 132 63246880
Smooth muscle cell neoplasm 25.53 9.56 23 241987 818 63246194
Orthostatic hypotension 25.52 9.56 63 241947 36097 63210915
Rhinocerebral mucormycosis 25.50 9.56 18 241992 447 63246565
Pneumonia adenoviral 25.49 9.56 12 241998 133 63246879
Microtia 25.48 9.56 17 241993 384 63246628
Lung adenocarcinoma 25.44 9.56 55 241955 4542 63242470
Adverse event 25.41 9.56 152 241858 67407 63179605
Pulmonary cavitation 25.23 9.56 23 241987 831 63246181
Septic arthritis staphylococcal 25.22 9.56 18 241992 455 63246557
Hyperhidrosis 25.15 9.56 276 241734 107560 63139452
Gastroenteritis viral 25.14 9.56 32 241978 23668 63223344
Retroperitoneal abscess 25.13 9.56 13 241997 179 63246833
Quadrantanopia 25.11 9.56 8 242002 26 63246986
Macular pseudohole 25.02 9.56 6 242004 3 63247009
Generalised oedema 24.99 9.56 123 241887 15695 63231317
Fungal endocarditis 24.95 9.56 14 241996 229 63246783
Neutrophilic panniculitis 24.89 9.56 9 242001 47 63246965
Uterine haematoma 24.88 9.56 8 242002 27 63246985
Pulmonary alveolar haemorrhage 24.86 9.56 55 241955 4613 63242399
Lymphatic fistula 24.86 9.56 22 241988 764 63246248
Oropharyngeal pain 24.86 9.56 235 241775 94252 63152760
Exostosis 24.84 9.56 19 241991 17843 63229169
Blast crisis in myelogenous leukaemia 24.76 9.56 19 241991 538 63246474
Ileal ulcer 24.72 9.56 18 241992 470 63246542
Emotional disorder 24.71 9.56 10 242000 13369 63233643
Corynebacterium infection 24.70 9.56 19 241991 540 63246472
Infected skin ulcer 24.66 9.56 37 241973 2295 63244717
Pneumonia pneumococcal 24.65 9.56 36 241974 2179 63244833
Steroid dependence 24.65 9.56 32 241978 1732 63245280
Atypical fracture 24.63 9.56 20 241990 616 63246396
Fungal test positive 24.61 9.56 19 241991 543 63246469
Deformity 24.59 9.56 7 242003 11677 63235335
Hypocomplementaemia 24.57 9.56 13 241997 188 63246824
Coeliac disease 24.57 9.56 9 242001 12788 63234224
Meconium stain 24.57 9.56 13 241997 188 63246824
Respiratory arrest 24.54 9.56 55 241955 32590 63214422
Lung consolidation 24.54 9.56 51 241959 4097 63242915
Mobility decreased 24.47 9.56 320 241690 120839 63126173
Coxsackie viral infection 24.45 9.56 8 242002 29 63246983
Bladder agenesis 24.43 9.56 12 241998 147 63246865
Sleep disorder due to a general medical condition 24.39 9.56 8 242002 12180 63234832
Blister 24.38 9.56 348 241662 129466 63117546
Left ventricular hypertrophy 24.33 9.56 59 241951 5256 63241756
Brain stem infarction 24.31 9.56 22 241988 787 63246225
Focal segmental glomerulosclerosis 24.31 9.56 29 241981 1439 63245573
Campylobacter infection 24.29 9.56 25 241985 1051 63245961
Peripheral T-cell lymphoma unspecified 24.27 9.56 13 241997 193 63246819
Hepatosplenomegaly 24.18 9.56 39 241971 2575 63244437
Duodenal ulcer repair 24.14 9.56 9 242001 52 63246960
Limb hypoplasia congenital 24.10 9.56 13 241997 196 63246816
Limb discomfort 24.07 9.56 48 241962 29668 63217344
Pneumonia chlamydial 24.07 9.56 10 242000 80 63246932
Colitis 24.06 9.56 287 241723 48241 63198771
Blood alkaline phosphatase increased 23.96 9.56 260 241750 42707 63204305
Genitalia external ambiguous 23.94 9.56 12 241998 154 63246858
Mediastinitis 23.92 9.56 13 241997 199 63246813
Locked-in syndrome 23.91 9.56 17 241993 427 63246585
Nephritis 23.91 9.56 38 241972 2478 63244534
Umbilical cord abnormality 23.90 9.56 20 241990 643 63246369
Blood calcium decreased 23.85 9.56 40 241970 26411 63220601
Metaphyseal corner fracture 23.83 9.56 8 242002 32 63246980
Impaired work ability 23.78 9.56 19 241991 17456 63229556
Epstein-Barr viraemia 23.77 9.56 24 241986 986 63246026
Epstein-Barr virus associated lymphoma 23.76 9.56 18 241992 500 63246512
Adverse drug reaction 23.74 9.56 192 241818 79522 63167490
Acute graft versus host disease in liver 23.69 9.56 20 241990 651 63246361
Gestational hypertension 23.66 9.56 37 241973 2380 63244632
Enterocolitis viral 23.62 9.56 14 241996 255 63246757
Ureterolithiasis 23.60 9.56 33 241977 1919 63245093
Blood pressure diastolic abnormal 23.58 9.56 13 241997 14529 63232483
Femoral hernia incarcerated 23.58 9.56 22 241988 819 63246193
Subileus 23.58 9.56 43 241967 3136 63243876
Muscle spasticity 23.56 9.56 29 241981 21765 63225247
Myelosuppression 23.54 9.56 163 241847 23540 63223472
Ophthalmic herpes zoster 23.52 9.56 34 241976 2039 63244973
Deafness neurosensory 23.42 9.56 55 241955 4800 63242212
Calciphylaxis 23.36 9.56 42 241968 3030 63243982
Meningoencephalitis herpetic 23.33 9.56 26 241984 1198 63245814
Infective tenosynovitis 23.31 9.56 15 241995 318 63246694
Caudal regression syndrome 23.22 9.56 12 241998 165 63246847
Post procedural hypothyroidism 23.15 9.56 14 241996 265 63246747
Coloboma 23.15 9.56 10 242000 89 63246923
Gastrointestinal perforation 23.14 9.56 45 241965 3446 63243566
Legionella infection 23.04 9.56 17 241993 453 63246559
Skin mass 23 9.56 62 241948 5893 63241119
Upper limb fracture 22.96 9.56 23 241987 18945 63228067
Ruptured cerebral aneurysm 22.92 9.56 17 241993 457 63246555
Conjunctival oedema 22.91 9.56 20 241990 682 63246330
Autoimmune hepatitis 22.88 9.56 78 241932 8432 63238580
Diffuse panbronchiolitis 22.87 9.56 5 242005 0 63247012
Nocardia sepsis 22.87 9.56 5 242005 0 63247012
Skin erosion 22.85 9.56 38 241972 2574 63244438
Panic attack 22.82 9.56 31 241979 22300 63224712
Visual acuity reduced 22.81 9.56 152 241858 21674 63225338
Cellulitis 22.78 9.56 439 241571 81519 63165493
Lymphocyte count decreased 22.75 9.56 195 241815 30062 63216950
Tissue infiltration 22.73 9.56 19 241991 610 63246402
Device related infection 22.72 9.56 160 241850 23232 63223780
Antinuclear antibody negative 22.72 9.56 13 241997 221 63246791
Infectious thyroiditis 22.64 9.56 7 242003 20 63246992
Encapsulating peritoneal sclerosis 22.63 9.56 15 241995 335 63246677
Shock haemorrhagic 22.61 9.56 86 241924 9809 63237203
Micrognathia 22.56 9.56 14 241996 278 63246734
Trichosporon infection 22.56 9.56 14 241996 278 63246734
Eye infection fungal 22.52 9.56 11 241999 133 63246879
Haematuria 22.50 9.56 189 241821 28968 63218044
Cerebellar stroke 22.47 9.56 14 241996 280 63246732
Retching 22.46 9.56 14 241996 14631 63232381
Chest X-ray abnormal 22.45 9.56 52 241958 4497 63242515
Head injury 22.41 9.56 44 241966 27352 63219660
Haemobilia 22.40 9.56 10 242000 97 63246915
Myositis 22.39 9.56 82 241928 9184 63237828
Pneumonia pseudomonal 22.36 9.56 37 241973 2496 63244516
Uveitis 22.31 9.56 101 241909 12452 63234560
Febrile bone marrow aplasia 22.26 9.56 70 241940 7255 63239757
Glomerulonephritis rapidly progressive 22.25 9.56 23 241987 972 63246040
Idiopathic pulmonary fibrosis 22.24 9.56 27 241983 1365 63245647
Peritoneal tuberculosis 22.23 9.56 17 241993 479 63246533
DNA antibody positive 22.21 9.56 15 241995 346 63246666
Juvenile idiopathic arthritis 22.20 9.56 43 241967 3283 63243729
Monoclonal B-cell lymphocytosis 22.09 9.56 8 242002 42 63246970
Candida infection 22.00 9.56 184 241826 28167 63218845
External auditory canal atresia 21.99 9.56 9 242001 69 63246943
Product storage error 21.99 9.56 15 241995 14941 63232071
Cutaneous T-cell lymphoma stage IV 21.98 9.56 6 242004 9 63247003
Pneumocystis test positive 21.98 9.56 6 242004 9 63247003
Malaise 21.94 9.56 1330 240680 414624 62832388
Hyperuricaemia 21.85 9.56 57 241953 5313 63241699
Anal abscess 21.83 9.56 52 241958 4580 63242432
Lung transplant rejection 21.77 9.56 22 241988 905 63246107
Human herpesvirus 6 infection reactivation 21.73 9.56 15 241995 359 63246653
Hepatic fibrosis 21.72 9.56 45 241965 3607 63243405
Nuchal rigidity 21.71 9.56 19 241991 650 63246362
Lip swelling 21.71 9.56 197 241813 30866 63216146
Congenital genital malformation 21.69 9.56 11 241999 145 63246867
Morganella infection 21.66 9.56 19 241991 652 63246360
Limb injury 21.64 9.56 40 241970 25437 63221575
Temperature intolerance 21.59 9.56 4 242006 8960 63238052
Putamen haemorrhage 21.56 9.56 12 241998 193 63246819
Placental insufficiency 21.49 9.56 27 241983 1414 63245598
Gastropleural fistula 21.49 9.56 8 242002 46 63246966
Renal artery thrombosis 21.47 9.56 10 242000 108 63246904
Head deformity 21.47 9.56 10 242000 108 63246904
Blood fibrinogen decreased 21.43 9.56 21 241989 832 63246180
Ligament sprain 21.41 9.56 11 241999 12789 63234223
Facial paralysis 21.35 9.56 108 241902 13933 63233079
Neutrophilia 21.34 9.56 50 241960 4356 63242656
Haematemesis 21.32 9.56 193 241817 30219 63216793
IgA nephropathy 21.29 9.56 18 241992 587 63246425
Thyroid disorder 21.25 9.56 16 241994 15146 63231866
Complication associated with device 21.24 9.56 20 241990 16958 63230054
Adenoviral haemorrhagic cystitis 21.23 9.56 11 241999 152 63246860
Renal tubular atrophy 21.18 9.56 20 241990 756 63246256
Bacteriuria 21.17 9.56 23 241987 1030 63245982
Leishmaniasis 21.14 9.56 9 242001 77 63246935
Hypersensitivity pneumonitis 21.14 9.56 37 241973 2613 63244399
Viral haemorrhagic cystitis 21.10 9.56 21 241989 848 63246164
Cytomegalovirus oesophagitis 21.09 9.56 13 241997 255 63246757
Paradoxical drug reaction 21.09 9.56 48 241962 4104 63242908
Lupus enteritis 21.07 9.56 8 242002 49 63246963
Varicella 21.06 9.56 31 241979 1890 63245122
Acute on chronic liver failure 21.03 9.56 12 241998 203 63246809
Glomerulonephritis membranoproliferative 20.98 9.56 12 241998 204 63246808
Meningoencephalitis bacterial 20.94 9.56 9 242001 79 63246933
Mucinous adenocarcinoma of appendix 20.90 9.56 6 242004 12 63247000
Hypertelorism 20.89 9.56 16 241994 452 63246560
Renal abscess 20.88 9.56 20 241990 770 63246242
Underdose 20.85 9.56 46 241964 27410 63219602
Intestinal tuberculosis 20.84 9.56 9 242001 80 63246932
Aortic aneurysm rupture 20.79 9.56 17 241993 529 63246483
Optic atrophy 20.76 9.56 25 241985 1253 63245759
Anterograde amnesia 20.76 9.56 17 241993 530 63246482
Cryoglobulinaemia 20.73 9.56 16 241994 457 63246555
Pulmonary artery thrombosis 20.73 9.56 19 241991 691 63246321
Oliguria 20.71 9.56 79 241931 9022 63237990
Coagulation test abnormal 20.71 9.56 20 241990 778 63246234
COVID-19 pneumonia 20.70 9.56 108 241902 14101 63232911
Blood cholesterol increased 20.63 9.56 244 241766 93788 63153224
Anhedonia 20.60 9.56 8 242002 10966 63236046
Bronchostenosis 20.58 9.56 16 241994 462 63246550
Bone infarction 20.58 9.56 14 241996 327 63246685
Seasonal allergy 20.49 9.56 30 241980 20920 63226092
Pregnancy on contraceptive 20.49 9.56 24 241986 1168 63245844
Duodenal ulcer perforation 20.42 9.56 223 241787 86986 63160026
Tethered cord syndrome 20.40 9.56 13 241997 271 63246741
Knee arthroplasty 20.36 9.56 122 241888 54084 63192928
Patent ductus arteriosus 20.34 9.56 48 241962 4202 63242810
Hospice care 20.31 9.56 3 242007 7929 63239083
Veillonella infection 20.29 9.56 7 242003 31 63246981
Infusion site swelling 20.29 9.56 6 242004 9764 63237248
Intrauterine infection 20.26 9.56 10 242000 124 63246888
Arthritis reactive 20.23 9.56 15 241995 403 63246609
Cardiovascular disorder 20.22 9.56 94 241916 11718 63235294
Aspergillus test positive 20.17 9.56 14 241996 338 63246674
Ocular lymphoma 20.17 9.56 8 242002 56 63246956
Cleft palate 20.16 9.56 22 241988 990 63246022
Streptococcal infection 20.13 9.56 58 241952 5729 63241283
Autoimmune disorder 20.03 9.56 123 241887 17054 63229958
Glossopharyngeal nerve paralysis 19.94 9.56 5 242005 4 63247008
Pelvic deformity 19.94 9.56 12 241998 225 63246787
Arterial thrombosis 19.89 9.56 26 241984 1417 63245595
Deep vein thrombosis postoperative 19.85 9.56 91 241919 11278 63235734
Otospondylomegaepiphyseal dysplasia 19.84 9.56 9 242001 91 63246921
Malacoplakia vesicae 19.81 9.56 8 242002 59 63246953
Staphylococcal bacteraemia 19.80 9.56 56 241954 5474 63241538
Pericarditis constrictive 19.78 9.56 14 241996 349 63246663
Gastrointestinal malformation 19.76 9.56 11 241999 177 63246835
Poisoning deliberate 19.74 9.56 9 242001 11209 63235803
Renal cell carcinoma 19.73 9.56 41 241969 3294 63243718
Ganglioneuroma 19.71 9.56 10 242000 132 63246880
Myasthenia gravis crisis 19.62 9.56 16 241994 496 63246516
Infective spondylitis 19.60 9.56 11 241999 180 63246832
Herpes zoster meningoencephalitis 19.59 9.56 13 241997 291 63246721
Bacillus infection 19.58 9.56 20 241990 833 63246179
Threatened labour 19.57 9.56 20 241990 834 63246178
Nail pigmentation 19.54 9.56 11 241999 181 63246831
Skin discolouration 19.53 9.56 76 241934 37752 63209260
Large intestine infection 19.53 9.56 30 241980 1900 63245112
Leiomyoma 19.51 9.56 15 241995 426 63246586
Tooth fracture 19.41 9.56 9 242001 11101 63235911
Diarrhoea haemorrhagic 19.36 9.56 77 241933 8965 63238047
Complement factor decreased 19.36 9.56 8 242002 63 63246949
Congenital coronary artery malformation 19.31 9.56 10 242000 138 63246874
Basal ganglion degeneration 19.30 9.56 15 241995 433 63246579
Blood pressure diastolic increased 19.29 9.56 7 242003 10003 63237009
Pneumonia acinetobacter 19.29 9.56 7 242003 37 63246975
Encephalitis autoimmune 19.29 9.56 26 241984 1460 63245552
Congenital ectopic bladder 19.25 9.56 9 242001 98 63246914
Atypical mycobacterial pneumonia 19.19 9.56 6 242004 18 63246994
Device breakage 19.18 9.56 10 242000 11532 63235480
Urticaria 19.18 9.56 483 241527 165319 63081693
Anaplastic large-cell lymphoma 19.17 9.56 9 242001 99 63246913
Glomerulonephritis membranous 19.15 9.56 17 241993 593 63246419
Ileal perforation 19.13 9.56 15 241995 439 63246573
Rectal cancer metastatic 19.09 9.56 12 241998 244 63246768
Nerve injury 19.09 9.56 7 242003 9939 63237073
Feeling hot 19.09 9.56 113 241897 50241 63196771
Histoplasmosis 19.05 9.56 30 241980 1941 63245071
Haemolysis 19.05 9.56 63 241947 6705 63240307
Dysphonia 19.05 9.56 105 241905 47509 63199503
C-reactive protein 19.03 9.56 51 241959 4831 63242181
Glomerulonephritis proliferative 19.02 9.56 11 241999 191 63246821
Granuloma skin 19.00 9.56 73 241937 8364 63238648
Keratitis 19 9.56 41 241969 3381 63243631
Systemic scleroderma 18.98 9.56 21 241989 960 63246052
Laryngitis 18.96 9.56 22 241988 16945 63230067
Lymphoplasmacytoid lymphoma/immunocytoma 18.95 9.56 5 242005 6 63247006
Thoracic vertebral fracture 18.95 9.56 49 241961 4543 63242469
Disease progression 18.92 9.56 607 241403 122151 63124861
Bacterial vulvovaginitis 18.89 9.56 19 241991 777 63246235
Wound dehiscence 18.89 9.56 51 241959 4852 63242160
Macular fibrosis 18.88 9.56 14 241996 376 63246636
Blood immunoglobulin M decreased 18.86 9.56 21 241989 967 63246045
Microangiopathic haemolytic anaemia 18.84 9.56 17 241993 606 63246406
Torsade de pointes 18.83 9.56 14 241996 13337 63233675
Eye abscess 18.82 9.56 10 242000 146 63246866
Epstein-Barr virus test positive 18.79 9.56 17 241993 608 63246404
Corneal scar 18.79 9.56 9 242001 104 63246908
Congenital oral malformation 18.77 9.56 11 241999 196 63246816
Postoperative wound infection 18.75 9.56 87 241923 10838 63236174
Gingivitis ulcerative 18.72 9.56 11 241999 197 63246815
Bulbar palsy 18.72 9.56 6 242004 20 63246992
Graft versus host disease in skin 18.71 9.56 37 241973 2868 63244144
Gram stain positive 18.69 9.56 7 242003 41 63246971
Product substitution issue 18.68 9.56 20 241990 15976 63231036
Abdominal tenderness 18.68 9.56 71 241939 8095 63238917
Caesarean section 18.64 9.56 120 241890 16912 63230100
Dermatitis allergic 18.64 9.56 110 241900 15038 63231974
Extrapyramidal disorder 18.64 9.56 14 241996 13270 63233742
Respiratory gas exchange disorder 18.63 9.56 14 241996 384 63246628
Plasma cell myeloma 18.63 9.56 72 241938 35833 63211179
Status asthmaticus 18.62 9.56 20 241990 884 63246128
Concussion 18.62 9.56 6 242004 9238 63237774
Pneumonia staphylococcal 18.58 9.56 37 241973 2883 63244129
Rhegmatogenous retinal detachment 18.56 9.56 9 242001 107 63246905
Granulomatosis with polyangiitis 18.56 9.56 32 241978 2233 63244779
Aplastic anaemia 18.53 9.56 79 241931 9490 63237522
Chest discomfort 18.52 9.56 301 241709 109668 63137344
Pseudomonal sepsis 18.48 9.56 33 241977 2368 63244644
Rheumatic disorder 18.44 9.56 38 241972 3034 63243978
Blood lactate dehydrogenase decreased 18.42 9.56 9 242001 109 63246903
Complications of transplanted liver 18.41 9.56 14 241996 391 63246621
Hydrocephalus 18.32 9.56 53 241957 5247 63241765
Akathisia 18.31 9.56 6 242004 9140 63237872
Renal infarct 18.30 9.56 25 241985 1422 63245590
Adactyly 18.28 9.56 7 242003 44 63246968
Brain compression 18.26 9.56 14 241996 396 63246616
Lymphoma transformation 18.24 9.56 10 242000 156 63246856
Encephalomyelitis 18.20 9.56 9 242001 112 63246900
Ureaplasma infection 18.20 9.56 17 241993 634 63246378
Tracheobronchitis 18.19 9.56 23 241987 1212 63245800
Keratitis fungal 18.18 9.56 10 242000 157 63246855
Ileus 18.17 9.56 107 241903 14618 63232394
Femur fracture 18.16 9.56 241 241769 41515 63205497
Lipomatosis 18.15 9.56 7 242003 45 63246967
Megakaryocytes increased 18.15 9.56 7 242003 45 63246967
Hypopharyngeal cancer 18.12 9.56 5 242005 8 63247004
Cytomegalovirus gastrointestinal ulcer 18.12 9.56 5 242005 8 63247004
Poor quality sleep 18.11 9.56 30 241980 19905 63227107
Haemorrhagic diathesis 18.10 9.56 47 241963 4368 63242644
Terminal ileitis 18.06 9.56 18 241992 728 63246284
Coronavirus infection 18.01 9.56 46 241964 4232 63242780
Intervertebral disc degeneration 18.01 9.56 20 241990 15712 63231300
Product prescribing error 18.00 9.56 166 241844 26123 63220889
Haptoglobin decreased 18.00 9.56 18 241992 731 63246281
Pleocytosis 17.94 9.56 19 241991 826 63246186
Leiomyosarcoma 17.92 9.56 11 241999 214 63246798
Protein-losing gastroenteropathy 17.92 9.56 11 241999 214 63246798
HELLP syndrome 17.91 9.56 21 241989 1023 63245989
Neutropenic infection 17.87 9.56 24 241986 1343 63245669
Duodenal ulcer haemorrhage 17.83 9.56 33 241977 2434 63244578
Venous thrombosis limb 17.81 9.56 37 241973 2971 63244041
Blood test abnormal 17.75 9.56 20 241990 15609 63231403
Herpes virus infection 17.72 9.56 54 241956 5502 63241510
Scleral disorder 17.72 9.56 9 242001 119 63246893
Reticulocytopenia 17.71 9.56 8 242002 80 63246932
Periodontitis 17.69 9.56 39 241971 3264 63243748
Fungal sepsis 17.68 9.56 23 241987 1247 63245765
B-cell lymphoma 17.67 9.56 39 241971 3266 63243746
Beta 2 microglobulin urine increased 17.65 9.56 7 242003 49 63246963
Mucocutaneous ulceration 17.58 9.56 10 242000 168 63246844
Abdominal compartment syndrome 17.57 9.56 16 241994 577 63246435
Abscess rupture 17.57 9.56 12 241998 282 63246730
Polyarthritis 17.56 9.56 81 241929 10065 63236947
Airway peak pressure increased 17.54 9.56 12 241998 283 63246729
Cardiac myxoma 17.53 9.56 11 241999 223 63246789
PO2 decreased 17.52 9.56 25 241985 1481 63245531
Ankylosing spondylitis 17.52 9.56 9 242001 10465 63236547
Retinal haemorrhage 17.48 9.56 50 241960 4919 63242093
Pneumonia aspiration 17.44 9.56 205 241805 34335 63212677
Cytomegalovirus duodenitis 17.41 9.56 5 242005 10 63247002
Omental necrosis 17.41 9.56 5 242005 10 63247002
Tongue necrosis 17.41 9.56 5 242005 10 63247002
Skin striae 17.41 9.56 24 241986 1377 63245635
Disseminated varicella zoster vaccine virus infection 17.41 9.56 7 242003 51 63246961
Mycobacterium kansasii infection 17.40 9.56 9 242001 124 63246888
Fracture 17.33 9.56 131 241879 19453 63227559
Ureteral necrosis 17.29 9.56 7 242003 52 63246960
Squamous cell carcinoma 17.29 9.56 72 241938 8560 63238452
Condition aggravated 17.24 9.56 1768 240242 400449 62846563
Needle issue 17.23 9.56 9 242001 10367 63236645
Mouth ulceration 17.21 9.56 197 241813 32787 63214225
Small cell lung cancer 17.20 9.56 26 241984 1623 63245389
Paraplegia 17.17 9.56 34 241976 2638 63244374
Cerebellar infarction 17.17 9.56 29 241981 1990 63245022
Blood lactate dehydrogenase abnormal 17.13 9.56 13 241997 362 63246650
Aplasia 17.12 9.56 45 241965 4214 63242798
Anencephaly 17.10 9.56 12 241998 295 63246717
Chronic hepatitis C 17.08 9.56 10 242000 178 63246834
Mesangioproliferative glomerulonephritis 17.07 9.56 7 242003 54 63246958
Vertigo 17.04 9.56 146 241864 59741 63187271
Epistaxis 17.01 9.56 186 241824 72539 63174473
Uterine perforation 17.00 9.56 3 242007 6960 63240052
Chest pain 16.98 9.56 662 241348 215297 63031715
Megacolon 16.94 9.56 28 241982 1887 63245125
Renal dysplasia 16.94 9.56 11 241999 237 63246775
Cytomegalovirus gastritis 16.93 9.56 10 242000 181 63246831
Chronic gastritis 16.89 9.56 35 241975 2806 63244206
Autoimmune haemolytic anaemia 16.87 9.56 47 241963 4554 63242458
Hodgkin's disease 16.84 9.56 18 241992 791 63246221
Ophthalmic herpes simplex 16.84 9.56 14 241996 446 63246566
Basal cell carcinoma 16.84 9.56 172 241838 27819 63219193
Ulcerative keratitis 16.84 9.56 34 241976 2676 63244336
Alternaria infection 16.82 9.56 11 241999 240 63246772
Pain in jaw 16.81 9.56 97 241913 43399 63203613
Cutaneous leishmaniasis 16.81 9.56 8 242002 91 63246921
Tooth dislocation 16.81 9.56 6 242004 30 63246982
Duodenal stenosis 16.80 9.56 15 241995 527 63246485
Hypozincaemia 16.79 9.56 5 242005 12 63247000
Enterovirus infection 16.74 9.56 20 241990 994 63246018
Pustular psoriasis 16.71 9.56 47 241963 4579 63242433
Histoplasmosis disseminated 16.69 9.56 24 241986 1432 63245580
Cryptosporidiosis infection 16.69 9.56 12 241998 307 63246705
Pulmonary sepsis 16.66 9.56 25 241985 1551 63245461
Hypochromic anaemia 16.65 9.56 28 241982 1914 63245098
Pharyngitis streptococcal 16.65 9.56 10 242000 10662 63236350
Respiratory tract infection 16.64 9.56 236 241774 41247 63205765
Post herpetic neuralgia 16.64 9.56 30 241980 2169 63244843
Asteatosis 16.64 9.56 7 242003 58 63246954
Live birth 16.63 9.56 160 241850 25470 63221542
Diffuse alveolar damage 16.63 9.56 19 241991 900 63246112
Graft complication 16.62 9.56 11 241999 245 63246767
Pustule 16.62 9.56 26 241984 1673 63245339
Large intestinal ulcer 16.59 9.56 39 241971 3405 63243607
PCO2 increased 16.57 9.56 22 241988 1217 63245795
Gastrointestinal haemorrhage 16.57 9.56 416 241594 80760 63166252
Glucose tolerance impaired 16.57 9.56 59 241951 6518 63240494
Blastomycosis 16.55 9.56 12 241998 311 63246701
Coma 16.54 9.56 161 241849 64203 63182809
Retinal drusen 16.51 9.56 5 242005 13 63246999
Congenital cytomegalovirus infection 16.51 9.56 5 242005 13 63246999
Parvimonas micra infection 16.51 9.56 5 242005 13 63246999
Oesophageal perforation 16.47 9.56 13 241997 384 63246628
Rhabdomyolysis 16.46 9.56 99 241911 43852 63203160
Rash vesicular 16.46 9.56 45 241965 4313 63242699
Iris transillumination defect 16.43 9.56 8 242002 96 63246916
Abortion missed 16.39 9.56 26 241984 1693 63245319
Cytokine release syndrome 16.38 9.56 102 241908 14212 63232800
Abdominal abscess 16.37 9.56 46 241964 4480 63242532
Extradural abscess 16.33 9.56 19 241991 918 63246094
Intestinal ischaemia 16.32 9.56 64 241946 7404 63239608
Increased tendency to bruise 16.31 9.56 10 242000 10542 63236470
Squamous cell carcinoma of skin 16.31 9.56 56 241954 6076 63240936
Creatinine renal clearance decreased 16.30 9.56 23 241987 16285 63230727
Tardive dyskinesia 16.29 9.56 6 242004 8496 63238516
Necrosis 16.28 9.56 52 241958 5435 63241577
Still's disease 16.25 9.56 5 242005 14 63246998
Thrombocytosis 16.24 9.56 54 241956 5764 63241248
Dengue fever 16.22 9.56 16 241994 639 63246373
Osteopenia 16.21 9.56 130 241880 19655 63227357
Jejunal ulcer perforation 16.19 9.56 6 242004 34 63246978
Premature separation of placenta 16.18 9.56 27 241983 1834 63245178
Musculoskeletal disorder 16.16 9.56 34 241976 20610 63226402
Sudden hearing loss 16.16 9.56 22 241988 1247 63245765
Brain oedema 16.15 9.56 101 241909 14094 63232918
Abdominal wall abscess 16.14 9.56 18 241992 830 63246182
Infective aneurysm 16.13 9.56 13 241997 396 63246616
Gastric cancer 16.11 9.56 47 241963 4676 63242336
Device malfunction 16.11 9.56 27 241983 17830 63229182
Osteomyelitis bacterial 16.10 9.56 10 242000 199 63246813
Nodal marginal zone B-cell lymphoma 16.07 9.56 4 242006 3 63247009
Portal vein stenosis 16.07 9.56 4 242006 3 63247009
Dermatitis psoriasiform 16.06 9.56 30 241980 2229 63244783
Central nervous system infection 16.05 9.56 17 241993 739 63246273
Localised infection 16.05 9.56 60 241950 30150 63216862
Vomiting 16.05 9.56 1878 240132 557739 62689273
Multiple sclerosis 16.02 9.56 44 241966 24328 63222684
Food allergy 16.02 9.56 12 241998 11389 63235623
Subclavian artery embolism 15.99 9.56 5 242005 15 63246997
Fear 15.99 9.56 22 241988 15744 63231268
Pelvic venous thrombosis 15.99 9.56 26 241984 1729 63245283
Influenza B virus test positive 15.98 9.56 11 241999 262 63246750
Bladder transitional cell carcinoma 15.97 9.56 16 241994 651 63246361
Evans syndrome 15.97 9.56 10 242000 202 63246810
Neutropenic colitis 15.96 9.56 36 241974 3059 63243953
Infusion site extravasation 15.95 9.56 10 242000 10416 63236596
Cryptococcal meningoencephalitis 15.94 9.56 8 242002 103 63246909
Leukaemia cutis 15.94 9.56 8 242002 103 63246909
Prinzmetal angina 15.91 9.56 17 241993 747 63246265
Aortic arteriosclerosis 15.90 9.56 56 241954 6153 63240859
Nasal septum disorder 15.89 9.56 9 242001 150 63246862
Subclavian vein thrombosis 15.88 9.56 27 241983 1863 63245149
Abscess neck 15.85 9.56 16 241994 657 63246355
Histiocytic sarcoma 15.85 9.56 7 242003 66 63246946
Pseudomembranous colitis 15.83 9.56 36 241974 3076 63243936
Cardio-respiratory arrest 15.82 9.56 149 241861 59810 63187202
Oral mucosa erosion 15.82 9.56 21 241989 1162 63245850
Stenotrophomonas infection 15.78 9.56 28 241982 1999 63245013
Congenital hydronephrosis 15.77 9.56 13 241997 409 63246603
Giant cell arteritis 15.76 9.56 30 241980 2261 63244751
Cytomegalovirus mucocutaneous ulcer 15.75 9.56 5 242005 16 63246996
Pelvic pain 15.68 9.56 17 241993 13502 63233510
Amniotic fluid volume increased 15.68 9.56 9 242001 154 63246858
Actinomycotic sepsis 15.67 9.56 8 242002 107 63246905
Salmonellosis 15.66 9.56 21 241989 1173 63245839
Scratch 15.66 9.56 3 242007 6562 63240450
Poor venous access 15.64 9.56 20 241990 14765 63232247
Stress fracture 15.62 9.56 66 241944 7897 63239115
Small intestinal ulcer haemorrhage 15.58 9.56 7 242003 69 63246943
Cushing's syndrome 15.58 9.56 16 241994 671 63246341
Hypoproteinaemia 15.56 9.56 28 241982 2021 63244991
Reticulin increased 15.54 9.56 4 242006 4 63247008
Infusion site erythema 15.52 9.56 13 241997 11666 63235346
Small intestine ulcer 15.48 9.56 12 241998 345 63246667
Lung lobectomy 15.48 9.56 8 242002 110 63246902
Body temperature decreased 15.46 9.56 34 241976 20285 63226727
Glomerulonephritis 15.44 9.56 26 241984 1780 63245232
Hepatic cyst 15.43 9.56 49 241961 5105 63241907
Mesenteric arterial occlusion 15.43 9.56 9 242001 159 63246853
Vitamin D decreased 15.42 9.56 10 242000 10232 63236780
Anastomotic stenosis 15.38 9.56 11 241999 279 63246733
Lymphangiectasia 15.32 9.56 7 242003 72 63246940
Red cell fragmentation syndrome 15.25 9.56 6 242004 41 63246971
Keratitis bacterial 15.25 9.56 6 242004 41 63246971
Conjunctival ulcer 15.25 9.56 6 242004 41 63246971
Transient hypogammaglobulinaemia of infancy 15.25 9.56 6 242004 41 63246971
Acute generalised exanthematous pustulosis 15.24 9.56 83 241927 11016 63235996
Anger 15.20 9.56 15 241995 12441 63234571
Immune-mediated myositis 15.20 9.56 22 241988 1321 63245691
Hepatitis acute 15.19 9.56 72 241938 9048 63237964
Clubbing 15.15 9.56 13 241997 433 63246579
Back injury 15.14 9.56 9 242001 9651 63237361
Fibrin degradation products increased 15.13 9.56 9 242001 165 63246847
Hepatic amoebiasis 15.10 9.56 5 242005 19 63246993
Phospholipidosis 15.09 9.56 9 242001 166 63246846
Vagus nerve paralysis 15.07 9.56 4 242006 5 63247007
Aspergillus test 15.07 9.56 4 242006 5 63247007
Tuberculosis gastrointestinal 15.02 9.56 12 241998 361 63246651
Diffuse large B-cell lymphoma stage IV 15.01 9.56 11 241999 290 63246722
Jejunal stenosis 15.00 9.56 6 242004 43 63246969
Joint tuberculosis 14.98 9.56 8 242002 118 63246894
Blood cholinesterase decreased 14.98 9.56 8 242002 118 63246894
Body height decreased 14.96 9.56 10 242000 10068 63236944
Eye irritation 14.95 9.56 39 241971 21932 63225080
Cough 14.89 9.56 939 241071 291804 62955208
Tubular breast carcinoma 14.89 9.56 6 242004 44 63246968
Myeloproliferative neoplasm 14.88 9.56 14 241996 527 63246485
Therapeutic response shortened 14.87 9.56 14 241996 11874 63235138
Sequestrectomy 14.82 9.56 17 241993 809 63246203
Frequent bowel movements 14.81 9.56 42 241968 22980 63224032
Aneurysm ruptured 14.81 9.56 14 241996 530 63246482
Poikilocytosis 14.81 9.56 9 242001 172 63246840
Neonatal respiratory distress syndrome 14.78 9.56 33 241977 2785 63244227
Seroma 14.77 9.56 28 241982 2103 63244909
Candida endophthalmitis 14.77 9.56 6 242004 45 63246967
Hip fracture 14.72 9.56 60 241950 29414 63217598
Acute graft versus host disease in intestine 14.71 9.56 25 241985 1724 63245288
Calculus urinary 14.69 9.56 22 241988 1362 63245650
Remission not achieved 14.69 9.56 8 242002 123 63246889
Deep vein thrombosis 14.69 9.56 421 241589 83379 63163633
Hysterectomy 14.68 9.56 9 242001 9490 63237522
Antimitochondrial antibody positive 14.68 9.56 7 242003 80 63246932
Enterovirus myocarditis 14.65 9.56 4 242006 6 63247006
Superinfection bacterial 14.63 9.56 15 241995 628 63246384
Drug reaction with eosinophilia and systemic symptoms 14.59 9.56 195 241815 33641 63213371
Henoch-Schonlein purpura 14.57 9.56 20 241990 1143 63245869
Hirsutism 14.56 9.56 22 241988 1373 63245639
Disability 14.55 9.56 30 241980 18317 63228695
Dystrophic calcification 14.52 9.56 8 242002 126 63246886
Leukocytosis 14.49 9.56 157 241853 25778 63221234
Toxoplasmosis 14.47 9.56 23 241987 1500 63245512
Pulmonary haemorrhage 14.46 9.56 60 241950 7121 63239891
Thrombophlebitis 14.45 9.56 43 241967 4325 63242687
Peritonitis viral 14.44 9.56 6 242004 48 63246964
Helicobacter gastritis 14.41 9.56 24 241986 1628 63245384
Intraductal papillary mucinous neoplasm 14.38 9.56 11 241999 310 63246702
Ulna fracture 14.37 9.56 20 241990 1158 63245854
Microscopic polyangiitis 14.36 9.56 9 242001 182 63246830
Non-Hodgkin's lymphoma 14.36 9.56 22 241988 1390 63245622
Impaired gastric emptying 14.36 9.56 11 241999 10321 63236691
Anal atresia 14.34 9.56 12 241998 386 63246626
Kidney rupture 14.33 9.56 6 242004 49 63246963
Appetite disorder 14.31 9.56 5 242005 7316 63239696
Haematoma infection 14.30 9.56 15 241995 645 63246367
Dyslipidaemia 14.29 9.56 61 241949 7332 63239680
Injection site discolouration 14.28 9.56 6 242004 7842 63239170
Pancreatic pseudocyst haemorrhage 14.27 9.56 4 242006 7 63247005
Parotid abscess 14.27 9.56 4 242006 7 63247005
Fibromyalgia 14.25 9.56 218 241792 80202 63166810
Tendon pain 14.25 9.56 36 241974 3290 63243722
Genital neoplasm malignant female 14.25 9.56 8 242002 131 63246881
Muscle haemorrhage 14.24 9.56 35 241975 3144 63243868
Lipohypertrophy 14.20 9.56 15 241995 650 63246362
Peritonsillar abscess 14.15 9.56 14 241996 561 63246451
Duodenal perforation 14.15 9.56 17 241993 850 63246162
Serratia infection 14.14 9.56 18 241992 955 63246057
Infective pulmonary exacerbation of cystic fibrosis 14.13 9.56 8 242002 8809 63238203
Pneumopericardium 14.13 9.56 6 242004 51 63246961
Gastroenteritis norovirus 14.12 9.56 27 241983 2041 63244971
Human polyomavirus infection 14.11 9.56 11 241999 319 63246693
Musculoskeletal pain 14.11 9.56 257 241753 92020 63154992
Lymphocytosis 14.06 9.56 32 241978 2735 63244277
Sensitivity to weather change 14.05 9.56 5 242005 7232 63239780
Hepatitis C RNA increased 14.04 9.56 8 242002 135 63246877
Gouty arthritis 14.03 9.56 14 241996 567 63246445
Spinal operation 13.99 9.56 7 242003 8264 63238748
Meningism 13.98 9.56 13 241997 482 63246530
Enterocolitis bacterial 13.97 9.56 10 242000 254 63246758
Abdominal distension 13.95 9.56 239 241771 86376 63160636
Gardner-Diamond syndrome 13.93 9.56 4 242006 8 63247004
Haematocolpos 13.93 9.56 6 242004 53 63246959
Toothache 13.90 9.56 33 241977 19166 63227846
Neural tube defect 13.90 9.56 9 242001 193 63246819
Lipodystrophy acquired 13.90 9.56 22 241988 1430 63245582
Product complaint 13.89 9.56 17 241993 12792 63234220
Skin necrosis 13.89 9.56 96 241914 13854 63233158
Amnesia 13.88 9.56 140 241870 55445 63191567
Immobile 13.86 9.56 52 241958 5891 63241121
Tibia fracture 13.83 9.56 47 241963 5073 63241939
Troponin I increased 13.81 9.56 28 241982 2210 63244802
Complications of transplanted lung 13.80 9.56 10 242000 259 63246753
Myelomalacia 13.74 9.56 6 242004 55 63246957
Flank pain 13.73 9.56 26 241984 16384 63230628
Scopulariopsis infection 13.72 9.56 3 242007 0 63247012
Bezold abscess 13.72 9.56 3 242007 0 63247012
Osteomyelitis salmonella 13.72 9.56 3 242007 0 63247012
Gastroenteritis sapovirus 13.72 9.56 3 242007 0 63247012
Glucose tolerance decreased 13.72 9.56 3 242007 0 63247012
Malignant glaucoma 13.72 9.56 3 242007 0 63247012
Tuberculous tenosynovitis 13.72 9.56 3 242007 0 63247012
Intraductal papillary-mucinous carcinoma of pancreas 13.72 9.56 3 242007 0 63247012
Anti-glomerular basement membrane antibody positive 13.72 9.56 3 242007 0 63247012
Chronic eosinophilic rhinosinusitis 13.72 9.56 3 242007 0 63247012
Endotoxic shock 13.72 9.56 3 242007 0 63247012
Meningoencephalitis amoebic 13.72 9.56 3 242007 0 63247012
Hyponatraemia 13.70 9.56 539 241471 111361 63135651
Vulval ulceration 13.68 9.56 11 241999 334 63246678
Kidney infection 13.68 9.56 44 241966 23132 63223880
Extranodal marginal zone B-cell lymphoma (MALT type) 13.67 9.56 13 241997 496 63246516
Upper-airway cough syndrome 13.65 9.56 14 241996 11404 63235608
Anal ulcer 13.63 9.56 14 241996 587 63246425
Aphonia 13.62 9.56 11 241999 10052 63236960
Corectopia 13.61 9.56 4 242006 9 63247003
Picornavirus infection 13.61 9.56 4 242006 9 63247003
Conjunctival deposit 13.61 9.56 4 242006 9 63247003
Sputum retention 13.61 9.56 14 241996 588 63246424
Otitis media acute 13.61 9.56 18 241992 992 63246020
Device leakage 13.61 9.56 5 242005 7091 63239921
Chronic graft versus host disease oral 13.58 9.56 8 242002 144 63246868
Acute hepatitis B 13.57 9.56 11 241999 338 63246674
Drug ineffective 13.56 9.56 3661 238349 1041104 62205908
Herpangina 13.54 9.56 5 242005 28 63246984
Vascular hyalinosis 13.54 9.56 5 242005 28 63246984
Rectal ulcer 13.52 9.56 20 241990 1225 63245787
Mouth injury 13.51 9.56 18 241992 999 63246013
Mood swings 13.51 9.56 31 241979 18217 63228795
Corneal epithelium defect 13.49 9.56 11 241999 341 63246671
Familial mediterranean fever 13.46 9.56 6 242004 58 63246954
Inguinal hernia 13.46 9.56 26 241984 1981 63245031
Gastroenteritis salmonella 13.45 9.56 15 241995 692 63246320
Eye disorder 13.44 9.56 43 241967 22642 63224370
Embolism venous 13.37 9.56 34 241976 3120 63243892
Red blood cell schistocytes present 13.35 9.56 10 242000 273 63246739
Upper respiratory tract infection 13.35 9.56 226 241784 81821 63165191
Exposure via body fluid 13.35 9.56 14 241996 602 63246410
Keratopathy 13.35 9.56 14 241996 602 63246410
Aphthous ulcer 13.34 9.56 95 241915 13843 63233169
Myelitis transverse 13.33 9.56 20 241990 1240 63245772
Cerebral fungal infection 13.31 9.56 7 242003 100 63246912
Vogt-Koyanagi-Harada disease 13.29 9.56 8 242002 150 63246862
Eosinophilic myocarditis 13.27 9.56 14 241996 606 63246406
Alpha haemolytic streptococcal infection 13.25 9.56 20 241990 1247 63245765
Acne 13.21 9.56 45 241965 23248 63223764
Nutritional condition abnormal 13.21 9.56 16 241994 807 63246205
Hypertrichosis 13.20 9.56 19 241991 1135 63245877
Dysplasia 13.20 9.56 17 241993 913 63246099
Rectal perforation 13.17 9.56 12 241998 433 63246579
Blood creatine phosphokinase decreased 13.16 9.56 13 241997 520 63246492
Hypersensitivity vasculitis 13.15 9.56 40 241970 4072 63242940
Vision blurred 13.14 9.56 259 241751 91665 63155347
Drug-induced liver injury 13.14 9.56 221 241789 40001 63207011
Urinary incontinence 13.13 9.56 70 241940 31944 63215068
Rheumatoid nodule 13.13 9.56 111 241899 17044 63229968
Bronchitis 13.12 9.56 369 241641 124566 63122446
Lupus myocarditis 13.11 9.56 6 242004 62 63246950
Abdominal pain upper 13.10 9.56 648 241362 205796 63041216
Transplant abscess 13.05 9.56 4 242006 11 63247001
Intra-abdominal haemorrhage 13.05 9.56 29 241981 2440 63244572
Toxic cardiomyopathy 13.02 9.56 8 242002 156 63246856
Abortion induced 13.01 9.56 75 241935 10167 63236845
Exposure via breast milk 13.01 9.56 26 241984 2031 63244981
Preterm premature rupture of membranes 13.01 9.56 21 241989 1388 63245624
Vascular pseudoaneurysm 13.00 9.56 22 241988 1512 63245500
Fungal skin infection 12.99 9.56 43 241967 4579 63242433
Beta-N-acetyl-D-glucosaminidase increased 12.98 9.56 5 242005 32 63246980
Parvovirus infection 12.98 9.56 10 242000 285 63246727
Endothelial dysfunction 12.97 9.56 8 242002 157 63246855
Retrognathia 12.97 9.56 12 241998 442 63246570
Cervical dysplasia 12.96 9.56 34 241976 3180 63243832
Jejunal perforation 12.95 9.56 7 242003 106 63246906
Sweat gland tumour 12.95 9.56 7 242003 106 63246906
Thrombotic thrombocytopenic purpura 12.92 9.56 38 241972 3798 63243214
Normochromic anaemia 12.89 9.56 10 242000 288 63246724
Cholecystitis acute 12.89 9.56 64 241946 8196 63238816
Steatohepatitis 12.88 9.56 14 241996 627 63246385
Cholecystectomy 12.86 9.56 13 241997 10664 63236348
Abortion spontaneous 12.84 9.56 252 241758 46943 63200069
Infected lymphocele 12.84 9.56 9 242001 221 63246791
Oral herpes 12.83 9.56 154 241856 25920 63221092
Infarction 12.83 9.56 30 241980 2611 63244401
Reactive gastropathy 12.81 9.56 12 241998 449 63246563
Febrile infection 12.76 9.56 22 241988 1535 63245477
Anal fistula 12.75 9.56 36 241974 3515 63243497
Gastrointestinal necrosis 12.74 9.56 31 241979 2767 63244245
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