prednisolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2245 50-24-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisolone
  • prenolone
  • deltahydrocortisone
  • hydroretrocortin
  • hydroretrocortine
  • metacortandralone
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
  • Molecular weight: 360.45
  • Formula: C21H28O5
  • CLOGP: 1.42
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.18
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.38 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 16 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.24 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 82 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.86 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.25 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 21, 1955 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumocystis jirovecii pneumonia 1154.34 9.54 723 201219 13940 50389242
Cytomegalovirus infection 895.60 9.54 668 201274 17294 50385888
Fatigue 679.03 9.54 1116 200826 706485 49696697
Pain 563.86 9.54 903 201039 578000 49825182
Sepsis 488.12 9.54 1397 200545 131528 50271654
Interstitial lung disease 421.26 9.54 759 201183 52417 50350765
Product dose omission issue 402.77 9.54 117 201825 183721 50219461
Completed suicide 402.52 9.54 33 201909 131856 50271326
Lymphoproliferative disorder 374.54 9.54 197 201745 2680 50400502
Product use in unapproved indication 373.62 9.54 1163 200779 114656 50288526
Abdominal discomfort 368.72 9.54 235 201707 231406 50171776
Hepatic function abnormal 348.17 9.54 533 201409 32148 50371034
Haemophagocytic lymphohistiocytosis 343.37 9.54 281 201661 8352 50394830
Bronchopulmonary aspergillosis 340.14 9.54 265 201677 7327 50395855
Epstein-Barr virus infection 312.97 9.54 244 201698 6753 50396429
Varicella zoster virus infection 286.38 9.54 157 201785 2332 50400850
Glossodynia 285.42 9.54 57 201885 115512 50287670
Pemphigus 285.06 9.54 65 201877 120101 50283081
Drug hypersensitivity 278.42 9.54 356 201586 250654 50152528
Pancytopenia 273.81 9.54 847 201095 83183 50319999
Nocardiosis 260.85 9.54 130 201812 1568 50401614
Posterior reversible encephalopathy syndrome 256.11 9.54 307 201635 14621 50388561
Sinusitis 255.24 9.54 185 201757 170373 50232809
Disseminated intravascular coagulation 254.84 9.54 328 201614 16807 50386375
Injection site pain 253.65 9.54 65 201877 110959 50292223
Swelling 252.98 9.54 257 201685 200615 50202567
Diffuse large B-cell lymphoma 250.11 9.54 196 201746 5466 50397716
Pyrexia 245.40 9.54 2454 199488 377749 50025433
Thrombotic microangiopathy 245.23 9.54 234 201708 8557 50394625
Hand deformity 244.13 9.54 51 201891 100148 50303034
Multiple organ dysfunction syndrome 241.57 9.54 585 201357 49752 50353430
Hepatitis B 240.72 9.54 158 201784 3308 50399874
Arthropathy 232.73 9.54 174 201768 157732 50245450
Osteonecrosis 231.07 9.54 361 201581 22156 50381026
Renal impairment 222.20 9.54 736 201206 74925 50328257
Anxiety 219.34 9.54 231 201711 177375 50225807
Post transplant lymphoproliferative disorder 217.66 9.54 160 201782 4044 50399138
Drug intolerance 212.03 9.54 342 201600 218762 50184420
Alopecia 210.55 9.54 412 201530 244635 50158547
Progressive multifocal leukoencephalopathy 210.43 9.54 244 201698 11213 50391969
Contraindicated product administered 205.87 9.54 175 201767 148783 50254399
Septic shock 200.94 9.54 592 201350 56583 50346599
Epstein-Barr virus associated lymphoproliferative disorder 195.60 9.54 107 201835 1582 50401600
Death 194.89 9.54 657 201285 324722 50078460
Transplant rejection 194.09 9.54 215 201727 9394 50393788
Pneumatosis intestinalis 191.84 9.54 114 201828 1989 50401193
Pulmonary tuberculosis 191.08 9.54 149 201793 4124 50399058
Joint swelling 187.73 9.54 440 201502 244846 50158336
Hepatitis B reactivation 187.43 9.54 112 201830 1975 50401207
Osteonecrosis of jaw 180.18 9.54 400 201542 32126 50371056
Respiratory failure 179.82 9.54 781 201161 90400 50312782
Cytomegalovirus colitis 179.81 9.54 106 201836 1821 50401361
Headache 178.92 9.54 1236 200706 505299 49897883
Premature delivery 178.73 9.54 331 201611 23332 50379850
Cytomegalovirus viraemia 178.34 9.54 149 201793 4560 50398622
Kidney transplant rejection 178.23 9.54 139 201803 3848 50399334
Synovitis 177.99 9.54 140 201802 123725 50279457
Atypical femur fracture 176.83 9.54 151 201791 4765 50398417
Nausea 174.17 9.54 1890 200052 703508 49699674
Pain in extremity 172.32 9.54 538 201404 272327 50130855
Hypogammaglobulinaemia 171.05 9.54 158 201784 5541 50397641
Aspergillus infection 168.69 9.54 170 201772 6651 50396531
Asthenia 166.93 9.54 681 201261 318361 50084821
Polyomavirus-associated nephropathy 165.16 9.54 93 201849 1459 50401723
Peripheral swelling 164.36 9.54 361 201581 205575 50197607
Hepatitis E 162.39 9.54 85 201857 1144 50402038
Discomfort 160.18 9.54 119 201823 108261 50294921
Toxicity to various agents 158.72 9.54 386 201556 212113 50191069
Disseminated tuberculosis 157.46 9.54 108 201834 2438 50400744
Weight increased 153.74 9.54 363 201579 201528 50201654
Leukopenia 152.43 9.54 603 201339 66925 50336257
Alveolar proteinosis 149.49 9.54 54 201888 266 50402916
Febrile neutropenia 145.08 9.54 771 201171 96896 50306286
BK virus infection 143.21 9.54 107 201835 2774 50400408
Liver disorder 142.97 9.54 398 201544 36824 50366358
Cushingoid 141.71 9.54 153 201789 6492 50396690
Strongyloidiasis 141.59 9.54 69 201873 790 50402392
Pneumocystis jirovecii infection 140.03 9.54 78 201864 1197 50401985
Pneumonia 139.14 9.54 2200 199742 376201 50026981
Nasopharyngitis 138.95 9.54 357 201585 192570 50210612
Blood lactate dehydrogenase increased 137.04 9.54 265 201677 19297 50383885
Anti-cyclic citrullinated peptide antibody positive 136.97 9.54 55 201887 70532 50332650
Therapeutic product effect decreased 135.63 9.54 208 201734 135842 50267340
C-reactive protein increased 134.57 9.54 574 201368 65900 50337282
JC virus infection 134.05 9.54 86 201856 1729 50401453
Muscle spasms 131.96 9.54 185 201757 125368 50277814
Dizziness 128.63 9.54 832 201110 345537 50057645
Pneumonia bacterial 128.13 9.54 152 201790 7157 50396025
General physical health deterioration 127.62 9.54 989 200953 141445 50261737
Depression 126.24 9.54 297 201645 165126 50238056
Chorioretinopathy 126.18 9.54 63 201879 763 50402419
Upper respiratory tract inflammation 126.11 9.54 92 201850 2297 50400885
Organising pneumonia 125.48 9.54 123 201819 4651 50398531
Pneumomediastinum 125.17 9.54 70 201872 1083 50402099
Cytomegalovirus test positive 123.81 9.54 94 201848 2498 50400684
Peritonitis 122.48 9.54 221 201721 15265 50387917
Drug abuse 120.49 9.54 44 201898 59802 50343380
Arthralgia 120.42 9.54 1145 200797 437557 49965625
Overdose 119.37 9.54 133 201809 99594 50303588
Arthritis bacterial 118.98 9.54 129 201813 5500 50397682
Steroid diabetes 118.49 9.54 63 201879 877 50402305
Insomnia 116.57 9.54 336 201606 174529 50228653
Feeling abnormal 116.52 9.54 201 201741 125291 50277891
Intentional overdose 115.99 9.54 52 201890 62452 50340730
Pruritus 115.77 9.54 661 201281 282907 50120275
Mycobacterium chelonae infection 115.13 9.54 49 201893 398 50402784
Hypersensitivity 115.08 9.54 455 201487 214706 50188476
Wound 115.08 9.54 152 201790 105642 50297540
Pneumonia cytomegaloviral 114.55 9.54 80 201862 1861 50401321
Off label use 113.88 9.54 2583 199359 471843 49931339
Irritable bowel syndrome 113.88 9.54 32 201910 51409 50351773
Systemic lupus erythematosus 113.36 9.54 245 201697 140377 50262805
Weight decreased 113.24 9.54 476 201466 220769 50182413
Pleurisy 111.62 9.54 142 201800 7189 50395993
Brain abscess 110.83 9.54 76 201866 1715 50401467
Gamma-glutamyltransferase increased 110.08 9.54 313 201629 29310 50373872
Cerebral infarction 110.00 9.54 257 201685 21347 50381835
Lupus nephritis 109.40 9.54 84 201858 2271 50400911
Platelet count decreased 109.02 9.54 732 201210 99994 50303188
Bone marrow failure 108.68 9.54 298 201644 27326 50375856
Staphylococcal sepsis 108.25 9.54 137 201805 6899 50396283
Disease recurrence 107.89 9.54 244 201698 19837 50383345
Exposure during pregnancy 105.46 9.54 835 201107 120180 50283002
Infection reactivation 104.64 9.54 59 201883 928 50402254
Injection site erythema 103.50 9.54 88 201854 74848 50328334
Wrong technique in product usage process 103.29 9.54 46 201896 55464 50347718
Agranulocytosis 102.77 9.54 249 201693 21172 50382010
Escherichia infection 102.08 9.54 168 201774 10773 50392409
Nephrotic syndrome 102.02 9.54 110 201832 4660 50398522
Alanine aminotransferase increased 101.61 9.54 652 201290 87707 50315475
Enterocolitis 101.25 9.54 128 201814 6439 50396743
Contusion 101.14 9.54 183 201759 112000 50291182
Tuberculosis 101.14 9.54 160 201782 9923 50393259
Migraine 100.84 9.54 91 201851 75189 50327993
Pneumonia cryptococcal 100.62 9.54 50 201892 599 50402583
Herpes zoster 100.47 9.54 552 201390 70234 50332948
Adult T-cell lymphoma/leukaemia 99.06 9.54 36 201906 181 50403001
Muscle injury 98.79 9.54 15 201927 37096 50366086
Oesophageal candidiasis 97.86 9.54 110 201832 4884 50398298
Hospitalisation 97.28 9.54 77 201865 67860 50335322
Hypotension 96.53 9.54 548 201394 234921 50168261
Meningitis cryptococcal 96.51 9.54 59 201883 1086 50402096
Immunosuppressant drug level increased 93.57 9.54 86 201856 2996 50400186
Rheumatoid factor positive 93.27 9.54 41 201901 49818 50353364
Musculoskeletal stiffness 92.25 9.54 238 201704 128243 50274939
Premature baby 92.12 9.54 217 201725 18120 50385062
Scleroderma renal crisis 92.11 9.54 37 201905 255 50402927
Pericarditis 91.92 9.54 107 201835 78582 50324600
Confusional state 91.44 9.54 406 201536 185522 50217660
Injection site reaction 90.69 9.54 43 201899 49989 50353193
Gastroenteritis 90.44 9.54 250 201692 23031 50380151
Aspartate aminotransferase increased 89.96 9.54 576 201366 77422 50325760
Pseudomonas infection 89.60 9.54 146 201796 9284 50393898
Gait disturbance 88.84 9.54 304 201638 149701 50253481
Thrombocytopenia 88.76 9.54 838 201104 126835 50276347
Sleep disorder due to general medical condition, insomnia type 87.75 9.54 11 201931 31436 50371746
Polyomavirus viraemia 87.69 9.54 41 201901 425 50402757
Fall 87.63 9.54 884 201058 334048 50069134
Mucormycosis 86.73 9.54 75 201867 2408 50400774
Vasculitis 86.58 9.54 180 201762 13811 50389371
Ill-defined disorder 86.03 9.54 56 201886 54598 50348584
Acute respiratory distress syndrome 85.38 9.54 230 201712 20869 50382313
Complications of transplanted kidney 84.87 9.54 70 201872 2103 50401079
Central nervous system lymphoma 84.65 9.54 58 201884 1307 50401875
Pulmonary nocardiosis 83.34 9.54 30 201912 146 50403036
Lymphopenia 83.02 9.54 189 201753 15432 50387750
Liver transplant rejection 82.03 9.54 56 201886 1254 50401928
Renal phospholipidosis 81.99 9.54 26 201916 78 50403104
Injection site bruising 81.14 9.54 23 201919 36745 50366437
Hepatic enzyme increased 80.27 9.54 280 201662 137100 50266082
Viraemia 79.55 9.54 51 201891 1024 50402158
Herpes simplex 79.34 9.54 119 201823 7043 50396139
Haemolytic anaemia 79.15 9.54 137 201805 9155 50394027
Low birth weight baby 77.31 9.54 106 201836 5775 50397407
Gestational diabetes 77.01 9.54 120 201822 7345 50395837
Stress 76.97 9.54 61 201881 53732 50349450
Unevaluable event 76.97 9.54 44 201898 46022 50357160
Diarrhoea 75.64 9.54 1781 200161 586695 49816487
Toxic epidermal necrolysis 75.27 9.54 219 201723 20773 50382409
Epstein Barr virus positive mucocutaneous ulcer 75.09 9.54 35 201907 360 50402822
Nasal congestion 74.37 9.54 57 201885 51063 50352119
Diffuse large B-cell lymphoma recurrent 74.33 9.54 57 201885 1538 50401644
Myopathy 74.29 9.54 132 201810 9007 50394175
Psoriasis 74.14 9.54 100 201842 68900 50334282
Neutropenic sepsis 73.89 9.54 170 201772 13977 50389205
Folliculitis 73.77 9.54 32 201910 39193 50363989
Cardiac failure 73.68 9.54 538 201404 75502 50327680
Adrenal suppression 73.67 9.54 45 201897 827 50402355
Symptom masked 73.67 9.54 41 201901 628 50402554
Balance disorder 73.15 9.54 105 201837 70485 50332697
Atypical mycobacterial infection 72.93 9.54 44 201898 790 50402392
Cytomegalovirus enteritis 72.30 9.54 29 201913 199 50402983
Blood pressure increased 72.09 9.54 280 201662 132852 50270330
Neutropenia 71.74 9.54 904 201038 147061 50256121
Drug eruption 71.35 9.54 232 201710 23374 50379808
Injection site pruritus 71.32 9.54 36 201906 40375 50362807
Hyperglycaemia 71.06 9.54 311 201631 36094 50367088
Back pain 71.03 9.54 550 201392 219480 50183702
Spinal compression fracture 70.47 9.54 156 201786 12500 50390682
Pleural effusion 70.35 9.54 561 201381 80893 50322289
Mental status changes 69.16 9.54 29 201913 36243 50366939
Multiple sclerosis relapse 69.02 9.54 43 201899 42921 50360261
Substance-induced psychotic disorder 68.84 9.54 55 201887 1578 50401604
Cytomegalovirus chorioretinitis 68.36 9.54 53 201889 1454 50401728
Proteinuria 68.24 9.54 182 201760 16415 50386767
Sedation 67.82 9.54 19 201923 30591 50372591
Gastric ulcer 67.68 9.54 213 201729 21092 50382090
Pyelonephritis 67.42 9.54 170 201772 14819 50388363
Lymphoma 67.16 9.54 130 201812 9471 50393711
Hypofibrinogenaemia 66.02 9.54 46 201896 1066 50402116
Cytomegalovirus infection reactivation 65.84 9.54 66 201876 2565 50400617
Cytomegalovirus enterocolitis 65.76 9.54 36 201906 533 50402649
Encephalitis 65.75 9.54 111 201831 7269 50395913
Tendon rupture 65.71 9.54 109 201833 7035 50396147
Treatment failure 65.57 9.54 304 201638 137333 50265849
Diabetes mellitus 65.34 9.54 376 201566 48657 50354525
Mycobacterium abscessus infection 65.28 9.54 35 201907 496 50402686
Immunosuppression 65.24 9.54 111 201831 7315 50395867
Oral candidiasis 65.07 9.54 181 201761 16734 50386448
Memory impairment 64.97 9.54 137 201805 79223 50323959
Electrocardiogram QT prolonged 64.51 9.54 67 201875 51819 50351363
Therapy cessation 63.81 9.54 13 201929 25998 50377184
Angiocentric lymphoma 63.77 9.54 35 201907 521 50402661
Foetal growth restriction 63.50 9.54 103 201839 6524 50396658
Skin ulcer 63.16 9.54 294 201648 35024 50368158
Blood pressure fluctuation 63.09 9.54 32 201910 35791 50367391
Chronic graft versus host disease 62.87 9.54 67 201875 2800 50400382
Injection site swelling 62.81 9.54 45 201897 41728 50361454
Blood beta-D-glucan increased 62.75 9.54 26 201916 196 50402986
Steroid withdrawal syndrome 62.73 9.54 34 201908 493 50402689
Heart rate increased 62.71 9.54 134 201808 77116 50326066
Mycobacterium avium complex infection 62.46 9.54 63 201879 2467 50400715
Constipation 62.39 9.54 459 201483 185249 50217933
Osteoporosis 62.34 9.54 348 201594 44531 50358651
Drug resistance 62.31 9.54 192 201750 18797 50384385
Klebsiella infection 61.19 9.54 106 201836 7088 50396094
Cardiac failure congestive 60.78 9.54 156 201786 84226 50318956
Large intestine perforation 60.60 9.54 108 201834 7386 50395796
Cryptococcosis 60.50 9.54 40 201902 848 50402334
Cerebrovascular accident 60.10 9.54 186 201756 94494 50308688
Bronchiectasis 59.81 9.54 129 201813 10154 50393028
Tuberculous pleurisy 59.53 9.54 30 201912 371 50402811
Infusion related reaction 59.42 9.54 414 201528 169143 50234039
Adrenal insufficiency 59.38 9.54 157 201785 14086 50389096
Drug ineffective 59.18 9.54 2672 199270 816661 49586521
Subarachnoid haemorrhage 59.07 9.54 132 201810 10644 50392538
Device dislocation 59.00 9.54 8 201934 21538 50381644
Hypoalbuminaemia 58.85 9.54 125 201817 9735 50393447
Listeria sepsis 58.35 9.54 34 201908 571 50402611
Product quality issue 58.30 9.54 25 201917 30833 50372349
Premature labour 57.85 9.54 136 201806 11340 50391842
Pneumothorax 57.81 9.54 154 201788 13880 50389302
Listeriosis 57.51 9.54 46 201896 1322 50401860
Normal newborn 57.45 9.54 99 201843 6592 50396590
Inappropriate schedule of product administration 57.14 9.54 126 201816 71705 50331477
Product use issue 56.89 9.54 356 201586 149119 50254063
Hepatic failure 56.46 9.54 267 201675 32016 50371166
Gastrointestinal disorder 56.18 9.54 191 201751 94265 50308917
Necrotising fasciitis 55.60 9.54 60 201882 2544 50400638
Rebound effect 55.37 9.54 66 201876 3123 50400059
Bacterial sepsis 55.04 9.54 70 201872 3542 50399640
Malignant neoplasm of conjunctiva 55.00 9.54 16 201926 32 50403150
Lymphocytic infiltration 54.97 9.54 37 201905 809 50402373
Colitis ulcerative 54.92 9.54 170 201772 16684 50386498
Infectious pleural effusion 54.81 9.54 42 201900 1132 50402050
Disseminated cryptococcosis 54.48 9.54 28 201914 362 50402820
Eosinophilic granulomatosis with polyangiitis 54.45 9.54 52 201890 1903 50401279
Parvovirus B19 infection 54.05 9.54 30 201912 457 50402725
Enterococcal infection 53.98 9.54 98 201844 6800 50396382
Aplasia pure red cell 53.95 9.54 75 201867 4140 50399042
Altered state of consciousness 53.78 9.54 201 201741 21709 50381473
Device issue 53.32 9.54 8 201934 19964 50383218
Therapy partial responder 53.32 9.54 95 201847 6496 50396686
Mycobacterial infection 53.31 9.54 47 201895 1549 50401633
Nephropathy toxic 52.88 9.54 106 201836 7923 50395259
Suicide attempt 52.56 9.54 78 201864 51654 50351528
Myelodysplastic syndrome 51.52 9.54 155 201787 14977 50388205
Helicobacter infection 51.42 9.54 74 201868 49628 50353554
Urosepsis 51.33 9.54 157 201785 15308 50387874
Lung infiltration 51.20 9.54 143 201799 13250 50389932
Bacteraemia 51.20 9.54 150 201792 14283 50388899
Full blood count decreased 51.15 9.54 13 201929 22333 50380849
Gastrooesophageal reflux disease 50.76 9.54 147 201795 76281 50326901
Somnolence 50.64 9.54 386 201556 154599 50248583
Foetal exposure during pregnancy 49.84 9.54 229 201713 27130 50376052
Rhinorrhoea 49.34 9.54 81 201861 51502 50351680
Immunosuppressant drug level decreased 49.17 9.54 35 201907 840 50402342
Muscle abscess 48.99 9.54 25 201917 318 50402864
Cerebral haemorrhage 48.97 9.54 226 201716 26826 50376356
Adverse drug reaction 48.92 9.54 91 201851 55131 50348051
Neck pain 48.85 9.54 96 201846 56971 50346211
Escherichia bacteraemia 48.46 9.54 61 201881 3055 50400127
Suicidal ideation 48.42 9.54 92 201850 55293 50347889
Placenta accreta 48.37 9.54 21 201921 180 50403002
Serotonin syndrome 48.34 9.54 19 201923 24694 50378488
Osteoporotic fracture 48.01 9.54 61 201881 3084 50400098
Pneumonitis 47.96 9.54 239 201703 29271 50373911
Inflammatory marker increased 47.90 9.54 83 201859 5551 50397631
Iron deficiency anaemia 47.80 9.54 162 201780 16672 50386510
Full blood count abnormal 47.40 9.54 17 201925 23371 50379811
Viral vasculitis 47.30 9.54 15 201927 45 50403137
Blood pressure systolic increased 47.28 9.54 43 201899 35406 50367776
Incorrect dose administered 47.27 9.54 75 201867 48339 50354843
Neuropathy peripheral 47.09 9.54 212 201730 96545 50306637
Subcutaneous emphysema 46.55 9.54 32 201910 725 50402457
Cerebral toxoplasmosis 46.44 9.54 31 201911 668 50402514
Graft versus host disease 46.23 9.54 86 201856 6080 50397102
Angiosarcoma 46.10 9.54 21 201921 204 50402978
Enteritis infectious 46.02 9.54 47 201895 1868 50401314
Endocarditis bacterial 45.91 9.54 29 201913 567 50402615
Meningitis listeria 45.84 9.54 27 201915 463 50402719
Meningitis bacterial 45.67 9.54 38 201904 1156 50402026
Splenomegaly 44.96 9.54 111 201831 9549 50393633
Staphylococcal infection 44.79 9.54 269 201673 35347 50367835
COVID-19 44.52 9.54 329 201613 46333 50356849
Injection site haemorrhage 44.14 9.54 15 201927 21331 50381851
Obliterative bronchiolitis 43.67 9.54 45 201897 1808 50401374
Drug ineffective for unapproved indication 43.22 9.54 184 201758 21097 50382085
Pancreatitis acute 43.15 9.54 199 201743 23613 50379569
Retinal detachment 42.87 9.54 75 201867 5054 50398128
Human T-cell lymphotropic virus type I infection 42.75 9.54 14 201928 48 50403134
Nervousness 42.61 9.54 29 201913 27622 50375560
Rheumatoid arthritis 42.56 9.54 561 201381 201989 50201193
Pulmonary embolism 42.49 9.54 605 201337 101099 50302083
Systemic mycosis 42.14 9.54 35 201907 1062 50402120
Infection in an immunocompromised host 42.02 9.54 25 201917 437 50402745
Bradycardia 42.00 9.54 125 201817 64301 50338881
Fluid retention 41.81 9.54 87 201855 50562 50352620
Duodenal ulcer 41.73 9.54 87 201855 6688 50396494
Intentional self-injury 41.67 9.54 20 201922 23092 50380090
Emotional distress 41.64 9.54 32 201910 28631 50374551
Subcutaneous abscess 41.61 9.54 72 201870 4810 50398372
White blood cell count increased 41.55 9.54 300 201642 41940 50361242
Foetal methotrexate syndrome 41.34 9.54 15 201927 75 50403107
Injury 41.27 9.54 83 201859 48842 50354340
Burning sensation 41.05 9.54 74 201868 45372 50357810
Secondary adrenocortical insufficiency 40.89 9.54 35 201907 1108 50402074
Erysipelas 40.87 9.54 85 201857 6523 50396659
Endocarditis 40.53 9.54 73 201869 5034 50398148
Lemierre syndrome 40.25 9.54 15 201927 82 50403100
Therapy interrupted 40.24 9.54 15 201927 20137 50383045
Joint stiffness 40.14 9.54 37 201905 30271 50372911
Sinus disorder 39.89 9.54 12 201930 18446 50384736
Intentional product misuse 39.67 9.54 79 201863 46655 50356527
Cholangitis 39.64 9.54 68 201874 4511 50398671
Rash 39.31 9.54 1390 200552 436081 49967101
Liver abscess 39.12 9.54 50 201892 2543 50400639
Heart rate decreased 39.09 9.54 53 201889 36444 50366738
Thymoma 39.08 9.54 14 201928 67 50403115
Erythema multiforme 39.00 9.54 101 201841 8949 50394233
Blister 38.71 9.54 192 201750 85226 50317956
Pyoderma gangrenosum 38.69 9.54 52 201890 2779 50400403
Haemolytic uraemic syndrome 38.64 9.54 47 201895 2272 50400910
Kaposi's sarcoma 38.63 9.54 17 201925 151 50403031
Accidental exposure to product 38.54 9.54 22 201920 23035 50380147
Influenza like illness 38.53 9.54 110 201832 57349 50345833
Shock 38.48 9.54 174 201768 20476 50382706
Scedosporium infection 38.32 9.54 23 201919 409 50402773
Immune thrombocytopenia 38.21 9.54 100 201842 8917 50394265
Ocular hypertension 38.18 9.54 29 201913 771 50402411
Chronic allograft nephropathy 38.18 9.54 27 201915 641 50402541
Drug interaction 38.16 9.54 1055 200887 198566 50204616
Leukoencephalopathy 38.09 9.54 61 201881 3822 50399360
Jaundice 38.08 9.54 207 201735 26222 50376960
Renal transplant failure 37.90 9.54 26 201916 587 50402595
Adrenal atrophy 37.81 9.54 11 201931 22 50403160
Ascites 37.79 9.54 259 201683 35602 50367580
Pneumoperitoneum 37.73 9.54 35 201907 1234 50401948
Drug withdrawal syndrome 37.73 9.54 27 201915 25054 50378128
Mycobacterium marinum infection 37.56 9.54 18 201924 198 50402984
Blood glucose increased 37.32 9.54 152 201790 71172 50332010
Central nervous system vasculitis 37.30 9.54 29 201913 799 50402383
Dyspepsia 36.86 9.54 161 201781 73936 50329246
Intraocular pressure increased 36.54 9.54 73 201869 5443 50397739
Pancreatic steatosis 36.44 9.54 30 201912 899 50402283
Opportunistic infection 36.42 9.54 39 201903 1639 50401543
Human herpesvirus 6 infection reactivation 36.32 9.54 15 201927 112 50403070
Crying 36.30 9.54 18 201924 20398 50382784
Systemic candida 36.24 9.54 50 201892 2740 50400442
Circulatory collapse 36.13 9.54 167 201775 19833 50383349
Injection site mass 36.13 9.54 9 201933 15671 50387511
Hypoaesthesia 36.09 9.54 329 201613 126928 50276254
Phaeohyphomycosis 35.98 9.54 18 201924 219 50402963
Acute graft versus host disease 35.88 9.54 60 201882 3898 50399284
Pyelonephritis acute 35.83 9.54 61 201881 4022 50399160
Fibromyalgia 35.68 9.54 79 201863 44899 50358283
Adenovirus infection 35.61 9.54 53 201889 3115 50400067
Hot flush 35.52 9.54 77 201865 44092 50359090
Acute abdomen 35.47 9.54 36 201906 1420 50401762
Duodenal ulcer perforation 35.46 9.54 81 201861 45530 50357652
Colon cancer 35.42 9.54 95 201847 8596 50394586
Limb reduction defect 35.35 9.54 21 201921 366 50402816
Diffuse large B-cell lymphoma refractory 35.33 9.54 31 201911 1015 50402167
Intussusception 35.33 9.54 22 201920 419 50402763
Arterial haemorrhage 35.23 9.54 37 201905 1520 50401662
Disseminated trichosporonosis 35.05 9.54 10 201932 18 50403164
Musculoskeletal chest pain 34.88 9.54 15 201927 18471 50384711
Tremor 34.83 9.54 292 201650 114611 50288571
Neuropsychiatric lupus 34.81 9.54 16 201926 159 50403023
Cognitive disorder 34.59 9.54 78 201864 44045 50359137
Necrotising retinitis 34.55 9.54 19 201923 284 50402898
Tachyarrhythmia 34.28 9.54 60 201882 4045 50399137
Antiphospholipid syndrome 34.24 9.54 36 201906 1481 50401701
Retinitis viral 34.07 9.54 9 201933 10 50403172
Blood glucose decreased 34.01 9.54 15 201927 18196 50384986
Secondary immunodeficiency 33.85 9.54 32 201910 1156 50402026
Cytomegalovirus hepatitis 33.74 9.54 19 201923 298 50402884
Femoral neck fracture 33.74 9.54 85 201857 7405 50395777
Tubulointerstitial nephritis 33.62 9.54 135 201807 15076 50388106
Knee arthroplasty 33.62 9.54 57 201885 35789 50367393
Intervertebral discitis 33.60 9.54 47 201895 2609 50400573
Meningitis 33.57 9.54 75 201867 6046 50397136
Concomitant disease aggravated 33.54 9.54 89 201853 8002 50395180
Cystitis haemorrhagic 33.40 9.54 56 201886 3646 50399536
Melaena 33.20 9.54 202 201740 26662 50376520
Poisoning 33.13 9.54 5 201937 12424 50390758
Escherichia urinary tract infection 33.08 9.54 104 201838 10291 50392891
Heart rate irregular 33.04 9.54 18 201924 19342 50383840
Lymph node tuberculosis 33.02 9.54 26 201916 730 50402452
Infusion site pain 32.83 9.54 5 201937 12341 50390841
Anaphylactoid reaction 32.72 9.54 53 201889 3353 50399829
Aortic dissection 32.60 9.54 36 201906 1567 50401615
Transplant failure 32.33 9.54 34 201908 1399 50401783
Psoriatic arthropathy 32.30 9.54 89 201853 46943 50356239
Alveolitis 32.30 9.54 45 201897 2489 50400693
Unresponsive to stimuli 32.23 9.54 45 201897 30564 50372618
Amnesia 32.09 9.54 76 201866 42184 50360998
Ecthyma 32.08 9.54 17 201925 235 50402947
Bone tuberculosis 32.03 9.54 16 201926 194 50402988
Acute graft versus host disease in skin 31.81 9.54 49 201893 2969 50400213
Panniculitis 31.73 9.54 90 201852 8413 50394769
Empyema 31.56 9.54 38 201904 1817 50401365
Haemorrhage subcutaneous 31.53 9.54 46 201896 2655 50400527
Restless legs syndrome 31.46 9.54 12 201930 15885 50387297
Synovectomy 31.38 9.54 15 201927 164 50403018
Primary biliary cholangitis 31.32 9.54 30 201912 1102 50402080
Meningitis tuberculous 31.31 9.54 22 201920 517 50402665
Lung abscess 31.19 9.54 35 201907 1551 50401631
Synostosis 31.16 9.54 11 201931 50 50403132
Cardiac valve vegetation 31.09 9.54 17 201925 251 50402931
Talipes 30.93 9.54 33 201909 1381 50401801
Feeling jittery 30.90 9.54 4 201938 11156 50392026
Type 1 diabetes mellitus 30.67 9.54 49 201893 3064 50400118
Sleep disorder 30.65 9.54 121 201821 57162 50346020
Dehydration 30.65 9.54 426 201516 152023 50251159
Growth retardation 30.64 9.54 29 201913 1049 50402133
Cytomegalovirus gastroenteritis 30.46 9.54 15 201927 176 50403006
Psoas abscess 30.41 9.54 20 201922 420 50402762
Adrenocortical insufficiency acute 30.36 9.54 33 201909 1411 50401771
Rheumatic disorder 30.26 9.54 34 201908 1509 50401673
Abscess 30.23 9.54 125 201817 14147 50389035
Blood creatinine increased 30.20 9.54 449 201493 75711 50327471
Tumour lysis syndrome 30.12 9.54 81 201861 7340 50395842
Enterococcal sepsis 30.11 9.54 31 201911 1244 50401938
Gallbladder rupture 30.10 9.54 19 201923 371 50402811
Neonatal hypoacusis 30.00 9.54 9 201933 21 50403161
Injection site warmth 29.99 9.54 9 201933 13857 50389325
Adverse event 29.92 9.54 83 201859 43680 50359502
Paraesthesia 29.86 9.54 321 201621 119922 50283260
Cardiac disorder 29.77 9.54 81 201861 42898 50360284
Microsporidia infection 29.76 9.54 16 201926 228 50402954
Auditory neuropathy spectrum disorder 29.71 9.54 9 201933 22 50403160
Small intestinal perforation 29.65 9.54 31 201911 1267 50401915
Pneumonia fungal 29.61 9.54 58 201884 4262 50398920
Lymphadenopathy 29.60 9.54 232 201710 33267 50369915
Ear infection 29.58 9.54 36 201906 25934 50377248
B-cell lymphoma recurrent 29.53 9.54 19 201923 384 50402798
Blood immunoglobulin G decreased 29.51 9.54 38 201904 1947 50401235
Central nervous system fungal infection 29.48 9.54 12 201930 86 50403096
Transaminases increased 29.34 9.54 201 201741 27623 50375559
Encephalitis viral 29.30 9.54 34 201908 1563 50401619
Epstein-Barr virus infection reactivation 29.25 9.54 21 201921 511 50402671
Dry eye 29.22 9.54 52 201890 32043 50371139
Lupus pancreatitis 29.21 9.54 7 201935 3 50403179
Cutaneous nocardiosis 29.15 9.54 9 201933 24 50403158
Graft versus host disease in gastrointestinal tract 29.10 9.54 45 201897 2736 50400446
Graft loss 29.08 9.54 18 201924 339 50402843
Retroperitoneal abscess 28.93 9.54 13 201929 122 50403060
Chest pain 28.91 9.54 514 201428 176368 50226814
Varicella zoster pneumonia 28.89 9.54 9 201933 25 50403157
Laboratory test abnormal 28.81 9.54 30 201912 23178 50380004
Diverticular perforation 28.69 9.54 48 201894 3120 50400062
Blood cholesterol increased 28.68 9.54 118 201824 55097 50348085
Interleukin-2 receptor increased 28.67 9.54 11 201931 66 50403116
Thyroiditis subacute 28.64 9.54 16 201926 247 50402935
Paraneoplastic pemphigus 28.59 9.54 10 201932 44 50403138
Pulmonary cavitation 28.58 9.54 23 201919 667 50402515
Substance-induced mood disorder 28.55 9.54 7 201935 4 50403178
Premature rupture of membranes 28.42 9.54 59 201883 4521 50398661
Carpal tunnel syndrome 28.41 9.54 16 201926 16877 50386305
Atypical haemolytic uraemic syndrome 28.39 9.54 21 201921 536 50402646
Nephritis 28.37 9.54 38 201904 2024 50401158
Abdominal pain upper 28.29 9.54 456 201486 158853 50244329
Lumbar vertebral fracture 28.27 9.54 59 201883 4538 50398644
Bedridden 28.25 9.54 92 201850 9275 50393907
Osteomyelitis 28.21 9.54 169 201773 22184 50380998
Injection site urticaria 28.17 9.54 7 201935 12210 50390972
Infective exacerbation of chronic obstructive airways disease 28.10 9.54 28 201914 1080 50402102
Seizure 27.94 9.54 318 201624 117556 50285626
Product monitoring error 27.91 9.54 44 201898 2720 50400462
Blood alkaline phosphatase increased 27.90 9.54 250 201692 37276 50365906
Trichophytosis 27.89 9.54 10 201932 48 50403134
Polyneuropathy 27.89 9.54 109 201833 12022 50391160
Muscle spasticity 27.87 9.54 17 201925 17167 50386015
Systemic inflammatory response syndrome 27.84 9.54 62 201880 4987 50398195
Purpura 27.81 9.54 95 201847 9816 50393366
Small for dates baby 27.69 9.54 50 201892 3455 50399727
Injection site rash 27.67 9.54 15 201927 16162 50387020
Rheumatoid vasculitis 27.52 9.54 17 201925 319 50402863
Infection masked 27.45 9.54 9 201933 31 50403151
Surgery 27.44 9.54 49 201893 30156 50373026
Coombs positive haemolytic anaemia 27.38 9.54 17 201925 322 50402860
Maternal exposure during pregnancy 27.37 9.54 833 201109 158945 50244237
Disseminated varicella zoster virus infection 27.36 9.54 11 201931 76 50403106
Herpes simplex reactivation 27.33 9.54 18 201924 379 50402803
Polyomavirus test positive 27.24 9.54 11 201931 77 50403105
Pneumonia pneumococcal 27.22 9.54 34 201908 1689 50401493
Mobility decreased 27.10 9.54 197 201745 79751 50323431
Cutaneous tuberculosis 27.05 9.54 13 201929 144 50403038
Sinus congestion 26.90 9.54 11 201931 13960 50389222
Flushing 26.84 9.54 157 201785 66858 50336324
Oligohydramnios 26.68 9.54 66 201876 5684 50397498
Anal prolapse 26.65 9.54 11 201931 82 50403100
Anuria 26.64 9.54 102 201840 11142 50392040
Herpes zoster meningitis 26.63 9.54 10 201932 56 50403126
Anaemia 26.60 9.54 1247 200695 251209 50151973
Infected skin ulcer 26.59 9.54 37 201905 2044 50401138
Cloacal exstrophy 26.59 9.54 13 201929 150 50403032
Dry skin 26.59 9.54 86 201856 43105 50360077
Loss of consciousness 26.54 9.54 277 201665 104076 50299106
Loss of personal independence in daily activities 26.54 9.54 167 201775 69883 50333299
B-cell lymphoma refractory 26.54 9.54 11 201931 83 50403099
Atrial septal defect 26.54 9.54 70 201872 6271 50396911
Bursitis infective staphylococcal 26.41 9.54 9 201933 36 50403146
Abscess bacterial 26.26 9.54 14 201928 196 50402986
Central obesity 26.24 9.54 26 201916 996 50402186
Visceral leishmaniasis 26.16 9.54 19 201923 471 50402711
Jaw operation 26.11 9.54 23 201919 757 50402425
Escherichia sepsis 26.02 9.54 55 201887 4269 50398913
Gastroenteritis clostridial 26.01 9.54 20 201922 542 50402640
Gastrointestinal amyloidosis 25.92 9.54 10 201932 61 50403121
Listeria encephalitis 25.89 9.54 15 201927 249 50402933
Lymphocele 25.81 9.54 23 201919 769 50402413
Colitis 25.79 9.54 251 201691 38278 50364904
Splenic abscess 25.78 9.54 11 201931 90 50403092
Throat irritation 25.76 9.54 51 201891 30188 50372994
Hepatitis 25.72 9.54 214 201728 31239 50371943
Hypocomplementaemia 25.71 9.54 13 201929 162 50403020
Lymphocyte stimulation test positive 25.61 9.54 19 201923 487 50402695
Bronchopleural fistula 25.59 9.54 14 201928 207 50402975
Aortic valve stenosis 25.52 9.54 44 201898 2931 50400251
Gait inability 25.48 9.54 70 201872 36957 50366225
Cell marker increased 25.43 9.54 15 201927 258 50402924
C-reactive protein abnormal 25.37 9.54 45 201897 27764 50375418
Gastrointestinal disorder congenital 25.36 9.54 12 201930 128 50403054
Lung adenocarcinoma 25.36 9.54 53 201889 4081 50399101
Fungal endocarditis 25.30 9.54 14 201928 212 50402970
Subileus 25.25 9.54 42 201900 2717 50400465
Respiratory arrest 25.23 9.54 51 201891 29958 50373224
Gallbladder disorder 25.21 9.54 18 201924 16724 50386458
Gastric cancer 25.06 9.54 44 201898 2974 50400208
Hypersomnia 25.05 9.54 15 201927 15299 50387883
Hypopyon 24.98 9.54 21 201921 648 50402534
Neutrophilic panniculitis 24.97 9.54 9 201933 44 50403138
Ileus paralytic 24.93 9.54 52 201890 3998 50399184
Atypical fracture 24.88 9.54 20 201922 579 50402603
Wound infection pseudomonas 24.87 9.54 28 201914 1245 50401937
Infective tenosynovitis 24.78 9.54 14 201928 221 50402961
Umbilical cord abnormality 24.76 9.54 20 201922 583 50402599
Quadrantanopia 24.75 9.54 8 201934 26 50403156
Macular pseudohole 24.75 9.54 6 201936 3 50403179
Sedation complication 24.62 9.54 3 201939 8763 50394419
Respiratory tract congestion 24.53 9.54 13 201929 14186 50388996
Ureterolithiasis 24.50 9.54 32 201910 1663 50401519
Meconium stain 24.38 9.54 13 201929 182 50403000
Viral haemorrhagic cystitis 24.34 9.54 21 201921 672 50402510
Generalised oedema 24.32 9.54 114 201828 13617 50389565
Limb hypoplasia congenital 24.32 9.54 13 201929 183 50402999
Pseudarthrosis 24.32 9.54 17 201925 396 50402786
Tooth infection 24.26 9.54 13 201929 14099 50389083
Brain stem infarction 24.21 9.54 22 201920 755 50402427
Bronchiolitis 24.18 9.54 38 201904 2343 50400839
Hyperuricaemia 24.17 9.54 56 201886 4624 50398558
Locked-in syndrome 24.17 9.54 16 201926 340 50402842
Bladder agenesis 24.13 9.54 12 201930 144 50403038
Chest X-ray abnormal 24.06 9.54 50 201892 3835 50399347
Corynebacterium infection 23.99 9.54 17 201925 405 50402777
Joint injury 23.99 9.54 31 201911 21758 50381424
Left ventricular hypertrophy 23.97 9.54 57 201885 4788 50398394
Intestinal perforation 23.96 9.54 94 201848 10385 50392797
Urticaria 23.96 9.54 368 201574 129193 50273989
Pleocytosis 23.90 9.54 19 201923 541 50402641
T-cell lymphoma 23.88 9.54 20 201922 614 50402568
Bacterial infection 23.78 9.54 128 201814 16153 50387029
Duodenal ulcer repair 23.74 9.54 9 201933 52 50403130
Focal segmental glomerulosclerosis 23.69 9.54 28 201914 1313 50401869
Genitalia external ambiguous 23.63 9.54 12 201930 151 50403031
Pneumonia chlamydial 23.63 9.54 10 201932 80 50403102
Hepatosplenomegaly 23.62 9.54 37 201905 2275 50400907
Eczema herpeticum 23.61 9.54 11 201931 113 50403069
IIIrd nerve paralysis 23.53 9.54 20 201922 627 50402555
Metaphyseal corner fracture 23.48 9.54 8 201934 32 50403150
Infectious thyroiditis 23.43 9.54 7 201935 16 50403166
Meningoencephalitis herpetic 23.41 9.54 25 201917 1047 50402135
Skin erosion 23.39 9.54 37 201905 2294 50400888
Pre-eclampsia 23.36 9.54 78 201864 7966 50395216
Emotional disorder 23.32 9.54 9 201933 11827 50391355
Ileal ulcer 23.25 9.54 17 201925 426 50402756
Blast crisis in myelogenous leukaemia 23.21 9.54 18 201924 494 50402688
Tooth disorder 23.21 9.54 38 201904 24190 50378992
Neuromyelitis optica spectrum disorder 23.06 9.54 22 201920 804 50402378
Myelosuppression 23.05 9.54 111 201831 13406 50389776
Cutaneous T-cell lymphoma stage IV 23.03 9.54 6 201936 6 50403176
Renal artery thrombosis 23.00 9.54 10 201932 86 50403096
Blood lactate dehydrogenase abnormal 22.97 9.54 13 201929 206 50402976
Hernia 22.93 9.54 5 201937 9538 50393644
Symblepharon 22.92 9.54 9 201933 58 50403124
Neisseria infection 22.91 9.54 8 201934 35 50403147
Lymphatic fistula 22.91 9.54 21 201921 729 50402453
DNA antibody positive 22.89 9.54 15 201927 313 50402869
Glomerulonephritis membranoproliferative 22.89 9.54 12 201930 162 50403020
Caudal regression syndrome 22.89 9.54 12 201930 162 50403020
Pneumonia acinetobacter 22.86 9.54 7 201935 18 50403164
Skin mass 22.84 9.54 58 201884 5077 50398105
Nephrolithiasis 22.83 9.54 67 201875 34626 50368556
Pulmonary alveolar haemorrhage 22.83 9.54 50 201892 3977 50399205
Coagulation test abnormal 22.77 9.54 20 201922 656 50402526
Femoral hernia incarcerated 22.65 9.54 21 201921 740 50402442
Diffuse panbronchiolitis 22.64 9.54 5 201937 0 50403182
Nocardia sepsis 22.64 9.54 5 201937 0 50403182
Respiratory tract infection 22.63 9.54 211 201731 31806 50371376
Limb discomfort 22.59 9.54 39 201903 24318 50378864
Device related infection 22.59 9.54 151 201791 20584 50382598
Nuchal rigidity 22.50 9.54 19 201923 590 50402592
Encapsulating peritoneal sclerosis 22.48 9.54 15 201927 323 50402859
Eye infection fungal 22.42 9.54 10 201932 92 50403090
Sleep apnoea syndrome 22.34 9.54 38 201904 23830 50379352
Diverticulum intestinal 22.34 9.54 63 201879 5870 50397312
Stevens-Johnson syndrome 22.27 9.54 156 201786 21596 50381586
Monoclonal B-cell lymphocytosis 22.21 9.54 8 201934 39 50403143
Mycotic endophthalmitis 22.21 9.54 8 201934 39 50403143
Underdose 22.17 9.54 29 201913 20249 50382933
Tethered cord syndrome 22.12 9.54 13 201929 222 50402960
Gastritis haemorrhagic 22.12 9.54 27 201915 1310 50401872
Meningoencephalitis bacterial 22.05 9.54 9 201933 65 50403117
Dyskinesia 22.04 9.54 49 201893 27812 50375370
Bronchostenosis 21.91 9.54 16 201926 400 50402782
Peritoneal tuberculosis 21.84 9.54 17 201925 469 50402713
Acute on chronic liver failure 21.84 9.54 12 201930 179 50403003
Influenza 21.83 9.54 240 201702 89298 50313884
Febrile bone marrow aplasia 21.82 9.54 65 201877 6246 50396936
Otospondylomegaepiphyseal dysplasia 21.82 9.54 9 201933 67 50403115
Head injury 21.79 9.54 39 201903 23981 50379201
Reversible cerebral vasoconstriction syndrome 21.77 9.54 34 201908 2085 50401097
Complication associated with device 21.75 9.54 16 201926 14639 50388543
Cellulitis 21.64 9.54 400 201542 70398 50332784
Hepatitis viral 21.64 9.54 16 201926 408 50402774
Keratitis 21.64 9.54 37 201905 2448 50400734
Blood pressure diastolic decreased 21.62 9.54 21 201921 16760 50386422
Orthostatic hypotension 21.61 9.54 54 201888 29427 50373755
Musculoskeletal pain 21.60 9.54 184 201758 71993 50331189
External auditory canal atresia 21.59 9.54 9 201933 69 50403113
Congenital genital malformation 21.55 9.54 11 201931 140 50403042
Streptococcal infection 21.51 9.54 54 201888 4694 50398488
Legionella infection 21.51 9.54 16 201926 412 50402770
Blood fibrinogen decreased 21.40 9.54 19 201923 632 50402550
Juvenile idiopathic arthritis 21.39 9.54 40 201902 2839 50400343
Mediastinitis 21.38 9.54 12 201930 187 50402995
Anterograde amnesia 21.36 9.54 17 201925 485 50402697
Glomerulonephritis rapidly progressive 21.34 9.54 21 201921 798 50402384
Calciphylaxis 21.31 9.54 38 201904 2600 50400582
Hyperhidrosis 21.29 9.54 241 201701 89185 50313997
Sneezing 21.28 9.54 15 201927 14029 50389153
Microangiopathic haemolytic anaemia 21.24 9.54 17 201925 489 50402693
Uterine haematoma 21.16 9.54 7 201935 25 50403157
Gastropleural fistula 21.13 9.54 8 201934 46 50403136
Gestational hypertension 21.13 9.54 34 201908 2139 50401043
Morganella infection 21.10 9.54 18 201924 567 50402615
Renal dysplasia 21.08 9.54 11 201931 147 50403035
Cryoglobulinaemia 21.08 9.54 16 201926 425 50402757
Endophthalmitis 21.03 9.54 40 201902 2876 50400306
Macular degeneration 20.98 9.54 16 201926 14372 50388810
Neutrophilia 20.96 9.54 45 201897 3530 50399652
Dysgeusia 20.94 9.54 82 201860 38834 50364348
Aplastic anaemia 20.88 9.54 73 201869 7630 50395552
Shock haemorrhagic 20.85 9.54 77 201865 8267 50394915
Myelopathy 20.83 9.54 37 201905 2524 50400658
Drug-induced liver injury 20.80 9.54 187 201755 27908 50375274
Ruptured cerebral aneurysm 20.79 9.54 16 201926 434 50402748
Optic atrophy 20.78 9.54 24 201918 1098 50402084
Adenoviral haemorrhagic cystitis 20.76 9.54 11 201931 152 50403030
Ligament sprain 20.74 9.54 8 201934 10517 50392665
Dry mouth 20.73 9.54 135 201807 56043 50347139
Lupus enteritis 20.71 9.54 8 201934 49 50403133
Heart transplant rejection 20.67 9.54 16 201926 438 50402744
Pneumonia haemophilus 20.66 9.54 17 201925 509 50402673
Procedural pain 20.66 9.54 15 201927 13817 50389365
Mucinous adenocarcinoma of appendix 20.62 9.54 6 201936 12 50403170
Anencephaly 20.57 9.54 12 201930 202 50402980
Retching 20.48 9.54 13 201929 12849 50390333
Antinuclear antibody negative 20.46 9.54 12 201930 204 50402978
Enterocolitis viral 20.41 9.54 12 201930 205 50402977
Oesophageal perforation 20.41 9.54 13 201929 258 50402924
Blood pressure diastolic abnormal 20.39 9.54 6 201936 9355 50393827
Illness 20.38 9.54 42 201900 24498 50378684
Lung consolidation 20.38 9.54 46 201896 3734 50399448
Aspergillus test positive 20.37 9.54 14 201928 317 50402865
Visual acuity reduced 20.36 9.54 144 201798 19995 50383187
Coxsackie viral infection 20.35 9.54 7 201935 29 50403153
Renal cell carcinoma 20.34 9.54 41 201901 3076 50400106
Cerebellar stroke 20.31 9.54 12 201930 207 50402975
Cytopenia 20.30 9.54 79 201863 8696 50394486
Anal abscess 20.29 9.54 46 201896 3745 50399437
Aphthous ulcer 20.27 9.54 90 201852 10507 50392675
Encephalitis cytomegalovirus 20.21 9.54 17 201925 525 50402657
Epstein-Barr virus associated lymphoma 20.21 9.54 16 201926 453 50402729
Temperature intolerance 20.17 9.54 3 201939 7536 50395646
Autoimmune hepatitis 20.16 9.54 71 201871 7448 50395734
Glomerulonephritis proliferative 20.14 9.54 11 201931 162 50403020
Infective spondylitis 20.08 9.54 11 201931 163 50403019
Granulomatosis with polyangiitis 20.07 9.54 30 201912 1770 50401412
Veillonella infection 19.98 9.54 7 201935 31 50403151
Product storage error 19.96 9.54 12 201930 12212 50390970
Anogenital warts 19.94 9.54 15 201927 393 50402789
Passenger lymphocyte syndrome 19.93 9.54 8 201934 55 50403127
Tissue infiltration 19.92 9.54 17 201925 536 50402646
Peripheral T-cell lymphoma unspecified 19.91 9.54 11 201931 166 50403016
Septic arthritis staphylococcal 19.91 9.54 15 201927 394 50402788
Pelvic deformity 19.81 9.54 12 201930 217 50402965
Malacoplakia vesicae 19.81 9.54 8 201934 56 50403126
Respiratory gas exchange disorder 19.81 9.54 14 201928 332 50402850
Clubbing 19.73 9.54 13 201929 274 50402908
Glossopharyngeal nerve paralysis 19.72 9.54 5 201937 4 50403178
Anaplastic large-cell lymphoma 19.70 9.54 9 201933 88 50403094
Blood immunoglobulin M decreased 19.70 9.54 19 201923 704 50402478
Polyarthritis 19.68 9.54 73 201869 7854 50395328
Squamous cell carcinoma of skin 19.51 9.54 55 201887 5123 50398059
Reticulocytopenia 19.46 9.54 8 201934 59 50403123
Gastrointestinal malformation 19.45 9.54 11 201931 174 50403008
Pericarditis constrictive 19.45 9.54 14 201928 342 50402840
Cardiovascular disorder 19.41 9.54 88 201854 10366 50392816
Gastroenteritis viral 19.40 9.54 28 201914 18758 50384424
Nail pigmentation 19.29 9.54 11 201931 177 50403005
Ganglioneuroma 19.27 9.54 10 201932 132 50403050
Blood lactate dehydrogenase decreased 19.27 9.54 9 201933 93 50403089
Putamen haemorrhage 19.23 9.54 11 201931 178 50403004
Status asthmaticus 19.22 9.54 20 201922 813 50402369
Upper limb fracture 19.16 9.54 21 201921 15852 50387330
Thoracic vertebral fracture 19.16 9.54 47 201895 4026 50399156
Rash vesicular 19.13 9.54 43 201899 3480 50399702
Hydronephrosis 19.03 9.54 76 201866 8465 50394717
Leiomyosarcoma 18.97 9.54 11 201931 183 50402999
Congenital oral malformation 18.91 9.54 11 201931 184 50402998
Disability 18.89 9.54 14 201928 12761 50390421
Myositis 18.89 9.54 72 201870 7848 50395334
Transplant dysfunction 18.89 9.54 51 201891 4633 50398549
Congenital ectopic bladder 18.86 9.54 9 201933 98 50403084
Trichosporon infection 18.85 9.54 12 201930 238 50402944
Megakaryocytes increased 18.82 9.54 7 201935 38 50403144
Ureaplasma infection 18.81 9.54 16 201926 502 50402680
Gingivitis ulcerative 18.81 9.54 11 201931 186 50402996
Head deformity 18.78 9.54 9 201933 99 50403083
Calculus urinary 18.78 9.54 21 201921 927 50402255
Haematemesis 18.75 9.54 181 201761 27544 50375638
Lymphoplasmacytoid lymphoma/immunocytoma 18.72 9.54 5 201937 6 50403176
Pneumocystis test positive 18.72 9.54 5 201937 6 50403176
Haematuria 18.71 9.54 170 201772 25443 50377739
Systemic scleroderma 18.70 9.54 20 201922 839 50402343
Herpes simplex viraemia 18.63 9.54 10 201932 142 50403040
Renal infarct 18.62 9.54 25 201917 1335 50401847
Thyroid disorder 18.61 9.54 14 201928 12663 50390519
Fungal sepsis 18.60 9.54 23 201919 1131 50402051
Aortic aneurysm rupture 18.60 9.54 16 201926 510 50402672
Femur fracture 18.60 9.54 230 201712 37234 50365948
Facial paralysis 18.59 9.54 100 201842 12615 50390567
Lymphoma transformation 18.57 9.54 10 201932 143 50403039
Macular fibrosis 18.54 9.54 14 201928 369 50402813
Duodenal ulcer haemorrhage 18.53 9.54 32 201910 2134 50401048
Cleft palate 18.51 9.54 21 201921 942 50402240
Lip swelling 18.49 9.54 165 201777 24571 50378611
Acute graft versus host disease in liver 18.48 9.54 17 201925 593 50402589
Megacolon 18.40 9.54 28 201914 1678 50401504
Oxygen saturation decreased 18.39 9.54 195 201747 73053 50330129
Oropharyngeal pain 18.39 9.54 210 201732 77591 50325591
Abscess rupture 18.37 9.54 12 201930 249 50402933
Gastritis 18.36 9.54 207 201735 32776 50370406
Threatened labour 18.34 9.54 19 201923 768 50402414
Ear pain 18.34 9.54 55 201887 28228 50374954
Wound dehiscence 18.32 9.54 48 201894 4282 50398900
Granuloma skin 18.32 9.54 58 201884 5760 50397422
Encephalomyelitis 18.32 9.54 9 201933 105 50403077
PO2 decreased 18.32 9.54 25 201917 1356 50401826
Varicella 18.31 9.54 28 201914 1686 50401496
Sudden hearing loss 18.26 9.54 22 201920 1053 50402129
Lipomatosis 18.24 9.54 7 201935 42 50403140
Adactyly 18.24 9.54 7 201935 42 50403140
Placental insufficiency 18.23 9.54 24 201918 1257 50401925
Hypersensitivity pneumonitis 18.18 9.54 33 201909 2289 50400893
Scleral disorder 18.17 9.54 9 201933 107 50403075
Dermatophytosis 18.15 9.54 10 201932 150 50403032
Paradoxical drug reaction 18.14 9.54 43 201899 3604 50399578
Pseudohypoaldosteronism 18.11 9.54 4 201938 0 50403182
Poikilocytosis 18.10 9.54 9 201933 108 50403074
Abdominal compartment syndrome 18.08 9.54 16 201926 530 50402652
Ulcerative keratitis 18.07 9.54 33 201909 2300 50400882
Abdominal tenderness 18.04 9.54 67 201875 7213 50395969
Oral herpes 18.02 9.54 143 201799 20582 50382600
Extradural abscess 18.00 9.54 19 201923 785 50402397
Intestinal tuberculosis 17.99 9.54 8 201934 73 50403109
Tooth fracture 17.94 9.54 8 201934 9643 50393539
Idiopathic pulmonary fibrosis 17.93 9.54 23 201919 1174 50402008
Small cell lung cancer 17.92 9.54 26 201916 1493 50401689
Panic attack 17.91 9.54 31 201911 19311 50383871
Hypopharyngeal cancer 17.89 9.54 5 201937 8 50403174
Human herpesvirus 6 infection 17.88 9.54 35 201907 2571 50400611
Hirsutism 17.81 9.54 21 201921 982 50402200
Mucocutaneous ulceration 17.81 9.54 10 201932 156 50403026
Histoplasmosis 17.76 9.54 28 201914 1731 50401451
Leiomyoma 17.75 9.54 14 201928 394 50402788
Basal ganglion degeneration 17.75 9.54 14 201928 394 50402788
Brain compression 17.74 9.54 13 201929 327 50402855
Conjunctival oedema 17.71 9.54 17 201925 626 50402556
Cardiac myxoma 17.69 9.54 11 201931 209 50402973
Blood pressure diastolic increased 17.68 9.54 4 201938 7439 50395743
Pulmonary sepsis 17.68 9.54 24 201918 1295 50401887
Impaired work ability 17.65 9.54 17 201925 13623 50389559
Skin discolouration 17.64 9.54 69 201873 32688 50370494
Pulmonary artery thrombosis 17.62 9.54 17 201925 630 50402552
Renal abscess 17.60 9.54 17 201925 631 50402551
HELLP syndrome 17.59 9.54 20 201922 899 50402283
Basal cell carcinoma 17.57 9.54 156 201786 23200 50379982
Anhedonia 17.54 9.54 8 201934 9516 50393666
Torsade de pointes 17.46 9.54 13 201929 11822 50391360
Peliosis hepatis 17.41 9.54 6 201936 25 50403157
Duodenal stenosis 17.36 9.54 15 201927 481 50402701
Squamous cell carcinoma 17.36 9.54 69 201873 7670 50395512
Vomiting 17.35 9.54 1593 200349 459165 49944017
Mycobacterium kansasii infection 17.33 9.54 9 201933 119 50403063
Nasal septum disorder 17.33 9.54 9 201933 119 50403063
Hepatic fibrosis 17.30 9.54 39 201903 3163 50400019
Periodontitis 17.28 9.54 38 201904 3031 50400151
Cutaneous leishmaniasis 17.27 9.54 8 201934 81 50403101
Iris transillumination defect 17.27 9.54 8 201934 81 50403101
Neutropenic colitis 17.24 9.54 33 201909 2384 50400798
Tooth dislocation 17.23 9.54 6 201936 26 50403156
Asteatosis 17.21 9.54 7 201935 50 50403132
Hydrocephalus 17.21 9.54 50 201892 4738 50398444
Hepatic cyst 17.20 9.54 48 201894 4445 50398737
Cytomegalovirus duodenitis 17.19 9.54 5 201937 10 50403172
Omental necrosis 17.19 9.54 5 201937 10 50403172
Tongue necrosis 17.19 9.54 5 201937 10 50403172
Retinal drusen 17.19 9.54 5 201937 10 50403172
PCO2 increased 17.18 9.54 22 201920 1121 50402061
Haemolysis 17.17 9.54 58 201884 5958 50397224
Intervertebral disc degeneration 17.16 9.54 17 201925 13444 50389738
Ophthalmic herpes zoster 17.12 9.54 27 201915 1670 50401512
Fungal test positive 17.10 9.54 15 201927 491 50402691
Disseminated varicella zoster vaccine virus infection 17.10 9.54 7 201935 51 50403131
Herpes zoster meningoencephalitis 17.08 9.54 12 201930 282 50402900
Airway peak pressure increased 17.04 9.54 12 201930 283 50402899
Bone erosion 17.03 9.54 13 201929 11674 50391508
Encephalitis autoimmune 17.03 9.54 23 201919 1235 50401947
Bone infarction 17.02 9.54 11 201931 224 50402958
Eye abscess 17.01 9.54 9 201933 124 50403058
Pregnancy on contraceptive 17.01 9.54 21 201921 1031 50402151
Ocular lymphoma 16.98 9.54 7 201935 52 50403130
Lung transplant rejection 16.91 9.54 18 201924 751 50402431
Eosinophilic myocarditis 16.91 9.54 13 201929 352 50402830
Patent ductus arteriosus 16.84 9.54 43 201899 3777 50399405
Foetal death 16.82 9.54 71 201871 8109 50395073
Fibrin degradation products increased 16.82 9.54 9 201933 127 50403055
Musculoskeletal disorder 16.81 9.54 27 201915 17322 50385860
Urinary incontinence 16.79 9.54 57 201885 28151 50375031
Leukaemia cutis 16.77 9.54 8 201934 87 50403095
Genital neoplasm malignant female 16.70 9.54 8 201934 88 50403094
Dysplasia 16.68 9.54 17 201925 674 50402508
Staphylococcal bacteraemia 16.64 9.54 50 201892 4827 50398355
Akathisia 16.64 9.54 6 201936 8223 50394959
Anal fistula 16.64 9.54 35 201907 2707 50400475
Histoplasmosis disseminated 16.63 9.54 23 201919 1263 50401919
Retinal haemorrhage 16.62 9.54 48 201894 4533 50398649
Dermatitis allergic 16.58 9.54 97 201845 12623 50390559
Pseudomonal sepsis 16.57 9.54 30 201912 2077 50401105
Hypozincaemia 16.57 9.54 5 201937 12 50403170
Keratitis bacterial 16.54 9.54 6 201936 30 50403152
Evans syndrome 16.50 9.54 10 201932 181 50403001
Caesarean section 16.50 9.54 113 201829 15526 50387656
Condition aggravated 16.50 9.54 1388 200554 295670 50107512
Deep vein thrombosis 16.49 9.54 396 201546 72908 50330274
Bacteriuria 16.48 9.54 17 201925 684 50402498
Corneal scar 16.46 9.54 8 201934 91 50403091
Lymphocyte count decreased 16.46 9.54 169 201773 26138 50377044
Hodgkin's disease 16.42 9.54 18 201924 777 50402405
Rectal cancer metastatic 16.40 9.54 11 201931 239 50402943
Prinzmetal angina 16.39 9.54 17 201925 688 50402494
Lung lobectomy 16.38 9.54 8 201934 92 50403090
Aortic arteriosclerosis 16.36 9.54 53 201889 5329 50397853
Cardio-respiratory arrest 16.30 9.54 137 201805 53755 50349427
Cerebellar infarction 16.28 9.54 27 201915 1742 50401440
Uveitis 16.27 9.54 77 201865 9233 50393949
Pseudomembranous colitis 16.27 9.54 35 201907 2750 50400432
Fracture 16.23 9.54 119 201823 16714 50386468
Postoperative wound infection 16.23 9.54 72 201870 8403 50394779
Parvovirus infection 16.22 9.54 10 201932 187 50402995
Protein-losing gastroenteropathy 16.22 9.54 10 201932 187 50402995
Diverticulum intestinal haemorrhagic 16.19 9.54 22 201920 1188 50401994
Glomerulonephritis membranous 16.19 9.54 15 201927 528 50402654
Ileal perforation 16.18 9.54 13 201929 376 50402806
Deafness neurosensory 16.17 9.54 47 201895 4454 50398728
Uterine perforation 16.17 9.54 3 201939 6412 50396770
Remission not achieved 16.16 9.54 8 201934 95 50403087
Pneumonia pseudomonal 16.16 9.54 29 201913 1994 50401188
Large intestinal ulcer 16.16 9.54 37 201905 3032 50400150
Henoch-Schonlein purpura 16.10 9.54 20 201922 988 50402194
Duodenal perforation 16.08 9.54 17 201925 704 50402478
Poor quality sleep 16.04 9.54 26 201916 16620 50386562
Extrapyramidal disorder 16.03 9.54 14 201928 11756 50391426
Small intestinal ulcer haemorrhage 16.02 9.54 7 201935 61 50403121
Malaise 16.00 9.54 1138 200804 334394 50068788
Stress fracture 15.99 9.54 62 201880 6813 50396369
Premature separation of placenta 15.97 9.54 26 201916 1652 50401530
Subclavian vein thrombosis 15.95 9.54 27 201915 1772 50401410
Haemorrhagic diathesis 15.93 9.54 43 201899 3905 50399277
Diffuse alveolar damage 15.93 9.54 18 201924 804 50402378
Jejunal ulcer perforation 15.92 9.54 6 201936 34 50403148
Infective aneurysm 15.89 9.54 13 201929 386 50402796
Portal vein stenosis 15.89 9.54 4 201938 3 50403179
Nodal marginal zone B-cell lymphoma 15.89 9.54 4 201938 3 50403179
Acne 15.88 9.54 34 201908 19561 50383621
Irritability 15.88 9.54 59 201883 28367 50374815
Aphonia 15.81 9.54 7 201935 8471 50394711
Tendon pain 15.79 9.54 36 201906 2942 50400240
Kidney rupture 15.78 9.54 6 201936 35 50403147
Epstein-Barr virus test positive 15.77 9.54 15 201927 546 50402636
Subclavian artery embolism 15.77 9.54 5 201937 15 50403167
Aneurysm ruptured 15.76 9.54 14 201928 466 50402716
Hypochromic anaemia 15.76 9.54 26 201916 1670 50401512
Histiocytic sarcoma 15.73 9.54 7 201935 64 50403118
Limb injury 15.71 9.54 36 201906 20214 50382968
Pustular psoriasis 15.71 9.54 43 201899 3938 50399244
Exostosis 15.70 9.54 14 201928 11639 50391543
Paraplegia 15.69 9.54 32 201910 2422 50400760
Herpes virus infection 15.69 9.54 49 201893 4832 50398350
Diffuse large B-cell lymphoma stage IV 15.67 9.54 11 201931 258 50402924
Mouth ulceration 15.66 9.54 176 201766 27848 50375334
Lymphocytosis 15.63 9.54 30 201912 2172 50401010
Candida infection 15.62 9.54 153 201789 23370 50379812
Amniotic fluid volume increased 15.61 9.54 9 201933 148 50403034
Small intestine ulcer 15.61 9.54 12 201930 325 50402857
Haptoglobin decreased 15.60 9.54 16 201926 639 50402543
Abnormal dreams 15.60 9.54 9 201933 9368 50393814
Autoimmune haemolytic anaemia 15.58 9.54 43 201899 3956 50399226
Influenza B virus test positive 15.56 9.54 11 201931 261 50402921
Bacterial endophthalmitis 15.53 9.54 5 201937 16 50403166
Cytomegalovirus mucocutaneous ulcer 15.53 9.54 5 201937 16 50403166
Immune-mediated myositis 15.53 9.54 20 201922 1025 50402157
Product substitution issue 15.47 9.54 20 201922 14037 50389145
Congenital hydronephrosis 15.47 9.54 13 201929 401 50402781
Blood cholinesterase decreased 15.46 9.54 8 201934 105 50403077
Nerve injury 15.40 9.54 7 201935 8343 50394839
Tuberculosis gastrointestinal 15.39 9.54 12 201930 332 50402850
Oral mucosa erosion 15.38 9.54 20 201922 1035 50402147
Conjunctival ulcer 15.36 9.54 6 201936 38 50403144
Epistaxis 15.36 9.54 172 201770 63782 50339400
Reticulin increased 15.36 9.54 4 201938 4 50403178
Vagus nerve paralysis 15.36 9.54 4 201938 4 50403178
Transplant abscess 15.36 9.54 4 201938 4 50403178
Blood creatine phosphokinase decreased 15.33 9.54 12 201930 334 50402848
Pneumonia staphylococcal 15.31 9.54 33 201909 2596 50400586
Chronic hepatitis C 15.30 9.54 9 201933 154 50403028
Arterial thrombosis 15.27 9.54 22 201920 1255 50401927
Gouty tophus 15.25 9.54 9 201933 155 50403027
Myelomalacia 15.23 9.54 6 201936 39 50403143
Intrauterine infection 15.20 9.54 8 201934 109 50403073
Gastroenteritis norovirus 15.20 9.54 26 201916 1721 50401461
Chronic graft versus host disease oral 15.13 9.54 8 201934 110 50403072
Tubular breast carcinoma 15.11 9.54 6 201936 40 50403142
Gram stain positive 15.11 9.54 6 201936 40 50403142
Neonatal respiratory distress syndrome 15.10 9.54 33 201909 2621 50400561
Stenosis 15.07 9.54 21 201921 1162 50402020
Steroid dependence 15.06 9.54 12 201930 343 50402839
Gastric ulcer perforation 15.05 9.54 20 201922 1057 50402125
Hip fracture 15.02 9.54 53 201889 25878 50377304
Plasma cell myeloma 15.00 9.54 69 201873 31253 50371929
Transient hypogammaglobulinaemia of infancy 14.98 9.54 6 201936 41 50403141
Gastrointestinal haemorrhage 14.98 9.54 391 201551 72930 50330252
Intestinal ischaemia 14.96 9.54 60 201882 6697 50396485
Coeliac disease 14.93 9.54 8 201934 8677 50394505
Cryptosporidiosis infection 14.93 9.54 11 201931 279 50402903
Infusion site swelling 14.91 9.54 5 201937 7171 50396011
Skin necrosis 14.91 9.54 84 201858 10783 50392399
Enterovirus myocarditis 14.89 9.54 4 201938 5 50403177
Aspergillus test 14.89 9.54 4 201938 5 50403177
Cytomegalovirus gastrointestinal ulcer 14.89 9.54 4 201938 5 50403177
Hepatic amoebiasis 14.87 9.54 5 201937 19 50403163
Pain in jaw 14.87 9.54 91 201851 38337 50364845
Otitis media acute 14.86 9.54 18 201924 866 50402316
Coma 14.86 9.54 150 201792 56729 50346453
Aplasia 14.86 9.54 41 201901 3772 50399410
Anger 14.81 9.54 14 201928 11319 50391863
Gouty arthritis 14.80 9.54 14 201928 506 50402676
Dermatomyositis 14.80 9.54 29 201913 2132 50401050
IgA nephropathy 14.76 9.54 13 201929 428 50402754
Product prescribing error 14.75 9.54 138 201804 20823 50382359
Jejunal stenosis 14.74 9.54 6 201936 43 50403139
Stenotrophomonas infection 14.73 9.54 25 201917 1644 50401538
Device breakage 14.72 9.54 10 201932 9537 50393645
Necrosis 14.72 9.54 47 201895 4689 50398493
Immune reconstitution inflammatory syndrome 14.72 9.54 52 201890 5464 50397718
Sensitivity to weather change 14.72 9.54 3 201939 5998 50397184
Fear 14.71 9.54 22 201920 14527 50388655
Concussion 14.70 9.54 6 201936 7622 50395560
Bulbar palsy 14.67 9.54 5 201937 20 50403162
Lipohypertrophy 14.65 9.54 15 201927 598 50402584
Thrombophlebitis 14.64 9.54 42 201900 3951 50399231
Salmonellosis 14.64 9.54 18 201924 880 50402302
Complement factor decreased 14.62 9.54 6 201936 44 50403138
Post herpetic neuralgia 14.61 9.54 27 201915 1899 50401283
Dengue fever 14.61 9.54 15 201927 600 50402582
Lipodystrophy acquired 14.60 9.54 22 201920 1307 50401875
Complications of transplanted liver 14.56 9.54 12 201930 360 50402822
Anal ulcer 14.51 9.54 14 201928 519 50402663
Hypertrichosis 14.51 9.54 19 201923 990 50402192
Candida endophthalmitis 14.51 9.54 6 201936 45 50403137
Meningomyelitis herpes 14.48 9.54 5 201937 21 50403161
Infarction 14.46 9.54 30 201912 2298 50400884
Tibia fracture 14.45 9.54 45 201897 4430 50398752
Chronic gastritis 14.41 9.54 30 201912 2304 50400878
Mechanical ileus 14.40 9.54 11 201931 295 50402887
Beta 2 microglobulin urine increased 14.39 9.54 6 201936 46 50403136
Blood calcium decreased 14.35 9.54 39 201903 20667 50382515
Sequestrectomy 14.35 9.54 17 201925 799 50402383
Inguinal hernia 14.33 9.54 25 201917 1681 50401501
Hypoproteinaemia 14.31 9.54 26 201916 1805 50401377
Exposure via body fluid 14.31 9.54 13 201929 446 50402736
Abortion missed 14.30 9.54 24 201918 1564 50401618
Helicobacter gastritis 14.29 9.54 23 201919 1447 50401735
Hepatitis C RNA increased 14.23 9.54 8 201934 125 50403057
Intraductal papillary mucinous neoplasm 14.21 9.54 11 201931 301 50402881
Rectal perforation 14.20 9.54 12 201930 373 50402809
Body height decreased 14.19 9.54 9 201933 8899 50394283
Peritonitis viral 14.18 9.54 6 201936 48 50403134
Increased tendency to bruise 14.16 9.54 10 201932 9346 50393836
Enterocolitis bacterial 14.16 9.54 9 201933 178 50403004
Myeloproliferative neoplasm 14.14 9.54 13 201929 453 50402729
Myasthenia gravis crisis 14.12 9.54 12 201930 376 50402806
Blood immunoglobulin M increased 14.12 9.54 10 201932 238 50402944
Thrombocytosis 14.11 9.54 48 201894 4948 50398234
Cytomegalovirus gastritis 14.11 9.54 9 201933 179 50403003
Ulna fracture 14.11 9.54 19 201923 1017 50402165
Pancreatic pseudocyst haemorrhage 14.09 9.54 4 201938 7 50403175
Erythema 14.09 9.54 717 201225 145697 50257485
Keratopathy 14.09 9.54 13 201929 455 50402727
Anastomotic stenosis 14.08 9.54 10 201932 239 50402943
Toxic cardiomyopathy 14.07 9.54 8 201934 128 50403054
Joint abscess 14.05 9.54 10 201932 240 50402942
Anal atresia 14.04 9.54 12 201930 379 50402803
Hepatitis acute 14.03 9.54 66 201876 7895 50395287
Osteoarthritis 14.03 9.54 191 201751 68415 50334767
Infective pulmonary exacerbation of cystic fibrosis 14.02 9.54 7 201935 7902 50395280
Tracheobronchitis 14.00 9.54 19 201923 1025 50402157
Oedematous pancreatitis 13.99 9.54 12 201930 381 50402801
Ureteral necrosis 13.97 9.54 6 201936 50 50403132
Endothelial dysfunction 13.96 9.54 8 201934 130 50403052
Cushing's syndrome 13.96 9.54 15 201927 633 50402549
Neural tube defect 13.94 9.54 9 201933 183 50402999
Vascular pseudoaneurysm 13.93 9.54 22 201920 1362 50401820
Non-Hodgkin's lymphoma 13.91 9.54 22 201920 1364 50401818
Lower limb fracture 13.90 9.54 101 201841 14145 50389037
Peripheral circulatory failure 13.88 9.54 14 201928 548 50402634
Reactive gastropathy 13.88 9.54 12 201930 385 50402797
Sleep disorder due to a general medical condition 13.88 9.54 6 201936 7365 50395817
Pulmonary haemorrhage 13.86 9.54 57 201885 6435 50396747
Sputum retention 13.83 9.54 13 201929 466 50402716
Abscess intestinal 13.82 9.54 22 201920 1371 50401811
Rhabdomyolysis 13.79 9.54 95 201847 38932 50364250
Respiratory tract infection fungal 13.75 9.54 12 201930 390 50402792
Gardner-Diamond syndrome 13.75 9.54 4 201938 8 50403174
Cryopyrin associated periodic syndrome 13.75 9.54 4 201938 8 50403174
Osteomyelitis bacterial 13.73 9.54 9 201933 188 50402994
Cerebral fungal infection 13.66 9.54 6 201936 53 50403129
Haematocolpos 13.66 9.54 6 201936 53 50403129
Bladder transitional cell carcinoma 13.65 9.54 13 201929 474 50402708
Tonsillitis 13.65 9.54 47 201895 4876 50398306
Grip strength decreased 13.60 9.54 17 201925 12104 50391078
Tardive dyskinesia 13.59 9.54 6 201936 7273 50395909
Febrile infection 13.58 9.54 20 201922 1164 50402018
Tuberculous tenosynovitis 13.58 9.54 3 201939 0 50403182
Anti-glomerular basement membrane antibody positive 13.58 9.54 3 201939 0 50403182
Glucose tolerance decreased 13.58 9.54 3 201939 0 50403182
Endotoxic shock 13.58 9.54 3 201939 0 50403182
Meningoencephalitis amoebic 13.58 9.54 3 201939 0 50403182
Bezold abscess 13.58 9.54 3 201939 0 50403182
Malignant glaucoma 13.58 9.54 3 201939 0 50403182
Osteomyelitis salmonella 13.58 9.54 3 201939 0 50403182
Gastroenteritis sapovirus 13.58 9.54 3 201939 0 50403182
Chronic eosinophilic rhinosinusitis 13.58 9.54 3 201939 0 50403182
Arthritis 13.53 9.54 254 201688 86467 50316715
Corneal epithelium defect 13.52 9.54 11 201931 324 50402858
Acute hepatitis B 13.52 9.54 11 201931 324 50402858
Keratitis fungal 13.52 9.54 7 201935 92 50403090
Renal tubular atrophy 13.51 9.54 14 201928 566 50402616
Pseudo-Bartter syndrome 13.47 9.54 6 201936 55 50403127
Mesenteric arterial occlusion 13.45 9.54 7 201935 93 50403089
Vertebral artery occlusion 13.45 9.54 7 201935 93 50403089
Pulmonary fibrosis 13.44 9.54 153 201789 24284 50378898
Infection susceptibility increased 13.44 9.54 31 201911 2553 50400629
Picornavirus infection 13.43 9.54 4 201938 9 50403173
Congenital cytomegalovirus infection 13.43 9.54 4 201938 9 50403173
Cryptococcus test positive 13.43 9.54 4 201938 9 50403173
Conjunctival deposit 13.43 9.54 4 201938 9 50403173
Skin striae 13.42 9.54 19 201923 1067 50402115
Vertigo 13.41 9.54 137 201805 51695 50351487
Herpangina 13.32 9.54 5 201937 28 50403154
Device malfunction 13.32 9.54 25 201917 15096 50388086
Glomerulonephritis 13.30 9.54 23 201919 1536 50401646
Chronic graft versus host disease in skin 13.29 9.54 15 201927 669 50402513
Muscle atrophy 13.27 9.54 54 201888 6067 50397115
Middle insomnia 13.27 9.54 12 201930 9909 50393273
Gastrointestinal oedema 13.26 9.54 19 201923 1079 50402103
Peritonsillar abscess 13.21 9.54 13 201929 494 50402688
Graft complication 13.20 9.54 9 201933 201 50402981
Retrognathia 13.20 9.54 12 201930 412 50402770
Multiple sclerosis 13.18 9.54 40 201902 20453 50382729
Infective glossitis 13.17 9.54 5 201937 29 50403153
Appetite disorder 13.17 9.54 4 201938 6110 50397072
Hyperbilirubinaemia 13.14 9.54 74 201868 9496 50393686
Large intestine erosion 13.14 9.54 4 201938 10 50403172
Granuloma 13.14 9.54 46 201896 4812 50398370
Central nervous system infection 13.13 9.54 15 201927 678 50402504
Intra-abdominal haemorrhage 13.08 9.54 28 201914 2192 50400990
Dermatitis psoriasiform 13.05 9.54 24 201918 1682 50401500
Superinfection bacterial 13.04 9.54 13 201929 502 50402680
Oligodendroglioma 13.03 9.54 5 201937 30 50403152
Gastrointestinal perforation 13.02 9.54 34 201908 3027 50400155
Microtia 13.02 9.54 11 201931 342 50402840
Jejunal perforation 13.01 9.54 7 201935 100 50403082
Abscess neck 13.00 9.54 14 201928 592 50402590
Serum ferritin increased 13.00 9.54 48 201894 5154 50398028
Bacillus infection 12.97 9.54 13 201929 505 50402677
Oliguria 12.97 9.54 66 201876 8150 50395032
Seroma 12.96 9.54 25 201917 1816 50401366
Aspergilloma 12.96 9.54 8 201934 150 50403032
Sweat gland tumour 12.94 9.54 7 201935 101 50403081
Abdominal sepsis 12.94 9.54 20 201922 1215 50401967
Human herpesvirus 6 encephalitis 12.91 9.54 8 201934 151 50403031
Acute lymphocytic leukaemia 12.90 9.54 28 201914 2213 50400969
Localised infection 12.90 9.54 55 201887 25430 50377752
B-lymphocyte count decreased 12.87 9.54 17 201925 893 50402289
Infertility 12.87 9.54 14 201928 599 50402583
Herpes simplex pneumonia 12.87 9.54 4 201938 11 50403171
Postrenal failure 12.82 9.54 7 201935 103 50403079
Embolism venous 12.81 9.54 30 201912 2495 50400687
Beta-N-acetyl-D-glucosaminidase increased 12.76 9.54 5 201937 32 50403150
Dermal sinus 12.76 9.54 5 201937 32 50403150
Normochromic anaemia 12.75 9.54 10 201932 279 50402903
Muscle haemorrhage 12.73 9.54 33 201909 2925 50400257
Vitamin D decreased 12.71 9.54 9 201933 8397 50394785
Abdominal abscess 12.66 9.54 40 201902 3968 50399214
Haematoma infection 12.64 9.54 13 201929 521 50402661
Drug reaction with eosinophilia and systemic symptoms 12.63 9.54 171 201771 28253 50374929
Injection site discolouration 12.63 9.54 6 201936 6968 50396214
Hypersensitivity vasculitis 12.62 9.54 40 201902 3975 50399207
Dysphonia 12.62 9.54 97 201845 38795 50364387
Pulmonary mucormycosis 12.61 9.54 9 201933 217 50402965
Glucose tolerance impaired 12.60 9.54 47 201895 5071 50398111
Pharyngitis streptococcal 12.58 9.54 10 201932 8798 50394384
Enterovirus infection 12.58 9.54 15 201927 710 50402472
Graft versus host disease in skin 12.57 9.54 30 201912 2526 50400656
Chest discomfort 12.55 9.54 278 201664 92444 50310738
Systemic infection 12.55 9.54 28 201914 2255 50400927
B-cell lymphoma 12.54 9.54 33 201909 2952 50400230
Hysterectomy 12.53 9.54 8 201934 7882 50395300
Polyuria 12.52 9.54 59 201883 7062 50396120
Ophthalmic herpes simplex 12.52 9.54 11 201931 361 50402821
Hypoglycaemia 12.51 9.54 145 201797 53436 50349746
Gastric disorder 12.49 9.54 68 201874 29480 50373702
Gastroenteritis salmonella 12.48 9.54 13 201929 529 50402653
Acute graft versus host disease in intestine 12.46 9.54 23 201919 1616 50401566
Ileus 12.46 9.54 93 201849 13136 50390046
Haemobilia 12.44 9.54 6 201936 67 50403115
Gastric stenosis 12.44 9.54 6 201936 67 50403115
Antimitochondrial antibody positive 12.44 9.54 6 201936 67 50403115
Oral administration complication 12.42 9.54 7 201935 110 50403072
Abortion spontaneous 12.41 9.54 235 201707 41537 50361645
Purulence 12.39 9.54 21 201921 1379 50401803
Device leakage 12.38 9.54 4 201938 5874 50397308
Comminuted fracture 12.38 9.54 13 201929 534 50402648
Lymphadenitis bacterial 12.38 9.54 4 201938 13 50403169
Still's disease 12.38 9.54 4 201938 13 50403169
Meningitis enteroviral 12.38 9.54 4 201938 13 50403169
Chorioretinal folds 12.38 9.54 4 201938 13 50403169
Dystrophic calcification 12.36 9.54 7 201935 111 50403071
Pancreatitis haemorrhagic 12.34 9.54 10 201932 293 50402889
Impaired gastric emptying 12.32 9.54 10 201932 8708 50394474
Abdominal wall abscess 12.32 9.54 15 201927 726 50402456
Joint tuberculosis 12.31 9.54 7 201935 112 50403070
Pelvic pain 12.29 9.54 16 201926 11197 50391985
Seasonal allergy 12.29 9.54 25 201917 14651 50388531
Actinomycotic sepsis 12.21 9.54 6 201936 70 50403112
Joint space narrowing 12.19 9.54 9 201933 229 50402953
Tubulointerstitial nephritis and uveitis syndrome 12.17 9.54 8 201934 168 50403014
Haematotoxicity 12.17 9.54 63 201879 7832 50395350
Abdominal distension 12.17 9.54 211 201731 72692 50330490
Cranial sutures widening 12.15 9.54 4 201938 14 50403168
Feeling hot 12.15 9.54 99 201843 39103 50364079
Central nervous system lupus 12.11 9.54 10 201932 301 50402881
Dysdiadochokinesis 12.09 9.54 7 201935 116 50403066
Vulval ulceration 12.09 9.54 9 201933 232 50402950
Emphysematous pyelonephritis 12.08 9.54 8 201934 170 50403012
Needle issue 12.08 9.54 7 201935 7268 50395914
Venous thrombosis limb 12.06 9.54 30 201912 2592 50400590
Klebsiella sepsis 12.06 9.54 19 201923 1174 50402008
Female reproductive neoplasm 12.03 9.54 5 201937 38 50403144
Adenomatous polyposis coli 12.03 9.54 5 201937 38 50403144
Abortion induced 12.02 9.54 71 201871 9273 50393909
Cytokine release syndrome 12.02 9.54 67 201875 8567 50394615
Giant cell arteritis 11.95 9.54 24 201918 1796 50401386
Infective aortitis 11.94 9.54 4 201938 15 50403167
Oesophageal squamous cell carcinoma stage IV 11.94 9.54 4 201938 15 50403167
Spinal operation 11.94 9.54 5 201937 6255 50396927
Product complaint 11.93 9.54 17 201925 11449 50391733
Paraspinal abscess 11.92 9.54 5 201937 39 50403143
Corneal abscess 11.92 9.54 5 201937 39 50403143
Meningomyelocele 11.92 9.54 13 201929 558 50402624
Anal cancer 11.91 9.54 12 201930 469 50402713
Polymicrogyria 11.85 9.54 6 201936 75 50403107
Smooth muscle cell neoplasm 11.84 9.54 15 201927 756 50402426
Epstein-Barr viraemia 11.83 9.54 16 201926 860 50402322
Blood corticotrophin decreased 11.83 9.54 9 201933 240 50402942
Exposed bone in jaw 11.81 9.54 31 201911 2769 50400413
Weaning failure 11.80 9.54 10 201932 312 50402870
Hip arthroplasty 11.80 9.54 72 201870 30357 50372825
Vasogenic cerebral oedema 11.79 9.54 12 201930 475 50402707
Feeding disorder 11.78 9.54 15 201927 10598 50392584
Streptococcal bacteraemia 11.77 9.54 21 201921 1437 50401745
Ankylosing spondylitis 11.74 9.54 7 201935 7158 50396024
Tonsillar exudate 11.74 9.54 4 201938 16 50403166
Crime 11.74 9.54 4 201938 16 50403166
Steatorrhoea 11.74 9.54 11 201931 393 50402789
Immunodeficiency common variable 11.73 9.54 7 201935 123 50403059
No adverse event 11.73 9.54 82 201860 33496 50369686
Rheumatoid nodule 11.70 9.54 89 201853 12646 50390536
Pneumonia legionella 11.69 9.54 20 201922 1324 50401858
Lentigo maligna 11.69 9.54 8 201934 180 50403002
Collagen disorder 11.65 9.54 8 201934 181 50403001
Leukoderma 11.64 9.54 6 201936 78 50403104
Laryngitis 11.64 9.54 16 201926 10940 50392242
Pulmonary infarction 11.63 9.54 28 201914 2370 50400812
Bursitis infective 11.58 9.54 19 201923 1215 50401967
Myalgia 11.57 9.54 393 201549 123926 50279256
Soft tissue infection 11.57 9.54 24 201918 1838 50401344
Blood test abnormal 11.56 9.54 17 201925 11302 50391880
Cardiac arrest 11.55 9.54 250 201692 83401 50319781
Enterocolitis haemorrhagic 11.55 9.54 20 201922 1337 50401845
Post transplant distal limb syndrome 11.53 9.54 8 201934 184 50402998
Thrombotic thrombocytopenic purpura 11.53 9.54 36 201906 3549 50399633
Glucose urine present 11.52 9.54 14 201928 676 50402506
Mean platelet volume 11.52 9.54 3 201939 3 50403179
Thought broadcasting 11.52 9.54 3 201939 3 50403179
Conjunctival neoplasm 11.52 9.54 3 201939 3 50403179
Tropical spastic paresis 11.52 9.54 3 201939 3 50403179
Plasminogen decreased 11.52 9.54 3 201939 3 50403179
Right atrial hypertrophy 11.52 9.54 3 201939 3 50403179
Fulminant type 1 diabetes mellitus 11.51 9.54 10 201932 323 50402859
Herpes simplex hepatitis 11.51 9.54 10 201932 323 50402859
Breast pain 11.50 9.54 8 201934 7536 50395646
Herpes simplex sepsis 11.50 9.54 5 201937 43 50403139
Pneumonitis chemical 11.50 9.54 8 201934 185 50402997
Trichodysplasia spinulosa 11.49 9.54 12 201930 490 50402692
Intentional dose omission 11.44 9.54 3 201939 5047 50398135
Aspartate aminotransferase abnormal 11.42 9.54 17 201925 999 50402183
Coombs negative haemolytic anaemia 11.42 9.54 8 201934 187 50402995
Pathogen resistance 11.40 9.54 49 201893 5640 50397542
Gastrointestinal erosion 11.39 9.54 13 201929 587 50402595
Nightmare 11.37 9.54 30 201912 16056 50387126
Leukocytosis 11.37 9.54 139 201803 22440 50380742
Angiosarcoma metastatic 11.36 9.54 4 201938 18 50403164
Muscular dystrophy 11.36 9.54 4 201938 18 50403164
Myelitis transverse 11.32 9.54 17 201925 1007 50402175
Protein urine present 11.31 9.54 47 201895 5330 50397852
Skin atrophy 11.31 9.54 40 201902 4205 50398977
Shunt infection 11.31 9.54 5 201937 45 50403137
Lichenification 11.28 9.54 11 201931 413 50402769
Poisoning deliberate 11.28 9.54 9 201933 7903 50395279
Parakeratosis 11.27 9.54 9 201933 258 50402924
Lipid metabolism disorder 11.21 9.54 5 201937 46 50403136
Endocarditis enterococcal 11.21 9.54 5 201937 46 50403136
Eosinophilic pneumonia 11.20 9.54 24 201918 1880 50401302
Pupillary disorder 11.20 9.54 8 201934 193 50402989
Stomatococcal infection 11.19 9.54 6 201936 85 50403097
Henoch-Schonlein purpura nephritis 11.19 9.54 4 201938 19 50403163
Infusion site extravasation 11.18 9.54 7 201935 6969 50396213
Pouchitis 11.18 9.54 11 201931 418 50402764
Hypervolaemia 11.16 9.54 58 201884 25441 50377741
Cholecystitis acute 11.16 9.54 57 201885 7049 50396133
Campylobacter infection 11.15 9.54 14 201928 699 50402483
Infusion site erythema 11.15 9.54 11 201931 8716 50394466
Rheumatoid lung 11.13 9.54 28 201914 2437 50400745
Poor venous access 11.09 9.54 15 201927 10325 50392857
Kidney infection 11.07 9.54 38 201904 18708 50384474
Haemarthrosis 11.07 9.54 31 201911 2877 50400305
Eastern Cooperative Oncology Group performance status 11.06 9.54 3 201939 4 50403178
Fibrosarcoma 11.06 9.54 3 201939 4 50403178
Parotid abscess 11.06 9.54 3 201939 4 50403178
Stress ulcer 11.03 9.54 5 201937 48 50403134
Malignant neoplasm of orbit 11.02 9.54 4 201938 20 50403162
Antineutrophil cytoplasmic antibody 11.02 9.54 4 201938 20 50403162
Cafe au lait spots 11.02 9.54 4 201938 20 50403162
Gastrointestinal candidiasis 11.01 9.54 6 201936 88 50403094
Acute myeloid leukaemia 10.99 9.54 100 201842 14974 50388208
Depressed mood 10.97 9.54 85 201857 33938 50369244
Infected lymphocele 10.92 9.54 8 201934 201 50402981
Lactic acidosis 10.91 9.54 83 201859 33272 50369910
Cervical dysplasia 10.91 9.54 30 201912 2755 50400427
Sense of oppression 10.90 9.54 16 201926 929 50402253
Graft versus host disease in lung 10.89 9.54 10 201932 348 50402834
Face oedema 10.87 9.54 114 201828 17725 50385457
Pustule 10.87 9.54 18 201924 1160 50402022
Acidosis 10.85 9.54 74 201868 10153 50393029
Toothache 10.85 9.54 33 201909 16861 50386321
Anaesthesia 10.84 9.54 10 201932 350 50402832
Ovarian cancer 10.83 9.54 45 201897 5104 50398078
Acinetobacter infection 10.82 9.54 20 201922 1407 50401775
Actinic keratosis 10.80 9.54 26 201916 2201 50400981
Neoplasm recurrence 10.79 9.54 27 201915 2342 50400840
Blood albumin decreased 10.79 9.54 90 201852 13146 50390036
Meningism 10.77 9.54 10 201932 353 50402829
Staphylococcus test positive 10.77 9.54 34 201908 3372 50399810
Malignant respiratory tract neoplasm 10.76 9.54 5 201937 51 50403131
Chronic myeloid leukaemia recurrent 10.75 9.54 8 201934 206 50402976
Parotitis 10.74 9.54 19 201923 1292 50401890
Red blood cell sedimentation rate increased 10.72 9.54 171 201771 29245 50373937
Cell-mediated immune deficiency 10.71 9.54 4 201938 22 50403160
Thrombocytopenia neonatal 10.71 9.54 4 201938 22 50403160
Laryngitis viral 10.71 9.54 4 201938 22 50403160
Duodenitis 10.68 9.54 33 201909 3235 50399947
Antineutrophil cytoplasmic antibody increased 10.68 9.54 5 201937 52 50403130
Sclerema 10.66 9.54 3 201939 5 50403177
Retinal infiltrates 10.66 9.54 3 201939 5 50403177
Pancreatic leak 10.66 9.54 3 201939 5 50403177
Autoimmune colitis 10.65 9.54 11 201931 443 50402739
Facial nerve disorder 10.65 9.54 12 201930 534 50402648
Labelled drug-drug interaction medication error 10.64 9.54 75 201867 10402 50392780
Eye irritation 10.64 9.54 34 201908 17106 50386076
Lung opacity 10.62 9.54 24 201918 1949 50401233
Upper respiratory tract irritation 10.60 9.54 5 201937 53 50403129
Ludwig angina 10.60 9.54 5 201937 53 50403129
Autoimmune thyroiditis 10.58 9.54 33 201909 3252 50399930
Polymyositis 10.57 9.54 21 201921 1559 50401623
Lymphangioma 10.57 9.54 4 201938 23 50403159
Extranodal marginal zone B-cell lymphoma (MALT type) 10.55 9.54 11 201931 448 50402734
Body temperature decreased 10.54 9.54 32 201910 16363 50386819
Fungal skin infection 10.52 9.54 36 201906 3723 50399459
Human polyomavirus infection 10.51 9.54 9 201933 285 50402897
Thrombosis 10.51 9.54 158 201784 55675 50347507
Pelvic venous thrombosis 10.50 9.54 19 201923 1315 50401867
Eosinophilic fasciitis 10.50 9.54 6 201936 97 50403085
Cholecystectomy 10.48 9.54 13 201929 9290 50393892
Osteochondrosis 10.48 9.54 17 201925 1077 50402105
Neurological decompensation 10.47 9.54 26 201916 2244 50400938
Congenital coronary artery malformation 10.44 9.54 6 201936 98 50403084
Umbilical cord vascular disorder 10.44 9.54 6 201936 98 50403084
Leukoerythroblastic anaemia 10.42 9.54 4 201938 24 50403158
Kidney congestion 10.42 9.54 4 201938 24 50403158
Corneal lesion 10.42 9.54 4 201938 24 50403158
Agitation 10.42 9.54 150 201792 53234 50349948
Haemodialysis 10.41 9.54 63 201879 8299 50394883
Gastric perforation 10.40 9.54 20 201922 1450 50401732
Complications of transplanted lung 10.40 9.54 8 201934 217 50402965
Cholecystitis chronic 10.39 9.54 14 201928 9655 50393527
Extremity necrosis 10.39 9.54 20 201922 1451 50401731
Device use error 10.38 9.54 4 201938 5262 50397920
Ileal stenosis 10.38 9.54 20 201922 1452 50401730
Rectal cancer 10.37 9.54 22 201920 1712 50401470
Mood swings 10.36 9.54 31 201911 15923 50387259
Chorioretinitis 10.35 9.54 11 201931 458 50402724
Guillain-Barre syndrome 10.35 9.54 34 201908 3443 50399739
Mitral valve incompetence 10.35 9.54 111 201831 17360 50385822
Cerebral venous thrombosis 10.34 9.54 23 201919 1848 50401334
Hyponatraemia 10.34 9.54 476 201466 95663 50307519
Large intestine infection 10.33 9.54 21 201921 1585 50401597
Abdominal wound dehiscence 10.32 9.54 7 201935 155 50403027
Asplenia 10.31 9.54 3 201939 6 50403176
Malignant urinary tract neoplasm 10.31 9.54 3 201939 6 50403176
Submaxillary gland enlargement 10.31 9.54 3 201939 6 50403176
Lividity 10.30 9.54 8 201934 220 50402962
Amylase increased 10.30 9.54 46 201896 5384 50397798
Oesophageal ulcer haemorrhage 10.29 9.54 10 201932 374 50402808
Acute generalised exanthematous pustulosis 10.29 9.54 66 201876 8872 50394310
Pathological fracture 10.29 9.54 59 201883 7623 50395559
Non-cardiac chest pain 10.27 9.54 5 201937 5727 50397455
Chronic myeloid leukaemia 10.27 9.54 25 201917 2131 50401051
Myelitis 10.26 9.54 18 201924 1216 50401966
Blood potassium decreased 10.25 9.54 96 201846 36849 50366333
Drug level fluctuating 10.22 9.54 10 201932 377 50402805
Weight bearing difficulty 10.22 9.54 26 201916 2278 50400904
Relapsing fever 10.21 9.54 7 201935 158 50403024
Gastrointestinal necrosis 10.19 9.54 28 201914 2570 50400612
Chronic inflammatory demyelinating polyradiculoneuropathy 10.18 9.54 10 201932 379 50402803
Preterm premature rupture of membranes 10.17 9.54 18 201924 1224 50401958
CSF protein increased 10.16 9.54 11 201931 468 50402714
Corneal graft rejection 10.16 9.54 4 201938 26 50403156
Hepatic rupture 10.16 9.54 4 201938 26 50403156
Rectal ulcer 10.15 9.54 17 201925 1106 50402076
Alternaria infection 10.15 9.54 8 201934 225 50402957
Menstruation irregular 10.13 9.54 6 201936 6156 50397026
Pneumonia aspiration 10.12 9.54 177 201765 30827 50372355
Atypical pneumonia 10.11 9.54 35 201907 3640 50399542
Anal sphincter atony 10.09 9.54 8 201934 227 50402955
Ureteric stenosis 10.08 9.54 12 201930 567 50402615
Alpha haemolytic streptococcal infection 10.07 9.54 15 201927 882 50402300
Intestinal infarction 10.07 9.54 16 201926 996 50402186
Lupus myocarditis 10.05 9.54 5 201937 60 50403122
Mycobacterial peritonitis 10.05 9.54 5 201937 60 50403122
Microscopic polyangiitis 10.05 9.54 7 201935 162 50403020
Post-acute COVID-19 syndrome 10.03 9.54 4 201938 27 50403155
Laparoscopic surgery 10.03 9.54 4 201938 27 50403155
Lacrimal haemorrhage 10.03 9.54 4 201938 27 50403155
Brain oedema 10.02 9.54 84 201858 12286 50390896
Nerve compression 10.01 9.54 9 201933 7453 50395729
Muscle twitching 10.01 9.54 30 201912 15401 50387781
Small intestine gangrene 10.00 9.54 3 201939 7 50403175
Transitional cell cancer of the renal pelvis and ureter 10.00 9.54 3 201939 7 50403175
Parophthalmia 10.00 9.54 9 201933 305 50402877
Extrapulmonary tuberculosis 10.00 9.54 9 201933 305 50402877
Inappropriate antidiuretic hormone secretion 9.99 9.54 88 201854 13055 50390127
Toxic skin eruption 9.98 9.54 78 201864 11173 50392009
Alanine aminotransferase 9.98 9.54 5 201937 61 50403121
Histology abnormal 9.98 9.54 6 201936 107 50403075
Craniosynostosis 9.98 9.54 7 201935 164 50403018
Hypokalaemia 9.97 9.54 438 201504 87554 50315628
Upper respiratory tract infection 9.97 9.54 194 201748 65704 50337478
Malacoplakia 9.93 9.54 6 201936 108 50403074
Hepatic artery thrombosis 9.91 9.54 5 201937 62 50403120
Nosocomial infection 9.91 9.54 20 201922 1502 50401680
Micrognathia 9.91 9.54 8 201934 233 50402949
Pseudomonas bronchitis 9.91 9.54 4 201938 28 50403154
Odontogenic cyst 9.91 9.54 4 201938 28 50403154
Intraocular pressure decreased 9.88 9.54 6 201936 109 50403073
Gene mutation 9.87 9.54 18 201924 1253 50401929
Nutritional condition abnormal 9.86 9.54 13 201929 682 50402500
Hemianopia homonymous 9.85 9.54 12 201930 581 50402601
Rectal ulcer haemorrhage 9.83 9.54 7 201935 168 50403014
Bicytopenia 9.82 9.54 23 201919 1913 50401269
Dry throat 9.81 9.54 5 201937 5579 50397603
Cholecystitis infective 9.80 9.54 20 201922 1514 50401668
Renal tubular acidosis 9.80 9.54 20 201922 1514 50401668
Acute psychosis 9.80 9.54 25 201917 2195 50400987
Injection site calcification 9.79 9.54 4 201938 29 50403153
Cancer in remission 9.79 9.54 4 201938 29 50403153
Stem cell transplant 9.79 9.54 21 201921 1647 50401535
Drug dependence 9.78 9.54 43 201899 19716 50383466
Road traffic accident 9.77 9.54 57 201885 24295 50378887
Tachypnoea 9.77 9.54 95 201847 14482 50388700
Eye disorder 9.76 9.54 40 201902 18699 50384483
Haemophilus infection 9.73 9.54 16 201926 1025 50402157
Eye infection 9.73 9.54 14 201928 9392 50393790
Pharyngitis bacterial 9.73 9.54 7 201935 171 50403011
Fasciitis 9.72 9.54 11 201931 492 50402690
Transferrin increased 9.72 9.54 3 201939 8 50403174
Carotid artery aneurysm 9.71 9.54 8 201934 240 50402942
Bone marrow oedema 9.70 9.54 14 201928 800 50402382
Pulmonary granuloma 9.70 9.54 18 201924 1270 50401912
Renal cyst infection 9.69 9.54 6 201936 113 50403069
Haemorrhagic ascites 9.69 9.54 6 201936 113 50403069
Red blood cell schistocytes present 9.68 9.54 8 201934 241 50402941
Mononeuropathy multiplex 9.68 9.54 8 201934 241 50402941
Mesangioproliferative glomerulonephritis 9.67 9.54 4 201938 30 50403152
Oedema due to cardiac disease 9.67 9.54 4 201938 30 50403152
Klebsiella test positive 9.65 9.54 15 201927 916 50402266
Pulmonary necrosis 9.65 9.54 6 201936 114 50403068
Acinetobacter test positive 9.64 9.54 5 201937 66 50403116
Leishmaniasis 9.64 9.54 5 201937 66 50403116
Meningitis pneumococcal 9.62 9.54 7 201935 174 50403008
Incorrect route of product administration 9.62 9.54 40 201902 18626 50384556
Anastomotic leak 9.62 9.54 10 201932 406 50402776
Intracranial pressure increased 9.61 9.54 38 201904 4214 50398968
Agnosia 9.60 9.54 6 201936 115 50403067
Cerebral mass effect 9.60 9.54 14 201928 808 50402374
Splenic infarction 9.57 9.54 20 201922 1540 50401642
Terminal ileitis 9.56 9.54 12 201930 599 50402583
Waxy flexibility 9.56 9.54 6 201936 116 50403066
Respiratory muscle weakness 9.56 9.54 6 201936 116 50403066

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 910.70 10.42 894 176149 22321 29375163
Pneumocystis jirovecii pneumonia 793.76 10.42 717 176326 16062 29381422
Product use in unapproved indication 471.35 10.42 1362 175681 85513 29311971
Completed suicide 394.23 10.42 41 177002 90205 29307279
Transplant rejection 393.54 10.42 372 176671 8840 29388644
Post transplant lymphoproliferative disorder 391.92 10.42 298 176745 5195 29392289
Death 387.30 10.42 930 176113 341154 29056330
Drug abuse 374.18 10.42 27 177016 79856 29317628
Hepatitis B 367.67 10.42 287 176756 5210 29392274
Product dose omission issue 366.46 10.42 67 176976 96316 29301168
Fatigue 315.21 10.42 918 176125 315903 29081581
Interstitial lung disease 304.17 10.42 896 176147 56822 29340662
Epstein-Barr virus infection 301.08 10.42 277 176766 6352 29391132
Nocardiosis 273.45 10.42 195 176848 3065 29394419
Polyomavirus-associated nephropathy 252.82 10.42 189 176854 3207 29394277
Strongyloidiasis 250.42 10.42 162 176881 2150 29395334
Kidney transplant rejection 231.28 10.42 246 176797 6759 29390725
Bronchopulmonary aspergillosis 230.46 10.42 325 176718 12019 29385465
Fall 213.22 10.42 465 176578 176713 29220771
Hepatitis B reactivation 212.50 10.42 167 176876 3062 29394422
Nausea 211.20 10.42 953 176090 288302 29109182
Osteonecrosis 210.72 10.42 327 176716 13192 29384292
Diffuse large B-cell lymphoma 208.27 10.42 221 176822 6055 29391429
Pyrexia 204.42 10.42 2621 174422 285001 29112483
Hepatitis E 203.04 10.42 126 176917 1548 29395936
Lymphoproliferative disorder 200.17 10.42 146 176897 2381 29395103
Complications of transplanted kidney 198.84 10.42 175 176868 3779 29393705
Haemophagocytic lymphohistiocytosis 193.78 10.42 275 176768 10229 29387255
Aspergillus infection 190.76 10.42 274 176769 10307 29387177
Asthenia 187.44 10.42 661 176382 214589 29182895
Hypotension 186.33 10.42 572 176471 193782 29203702
Transplant dysfunction 181.74 10.42 132 176911 2138 29395346
Overdose 178.94 10.42 130 176913 79689 29317795
Anxiety 173.87 10.42 153 176890 85212 29312272
Pulmonary nocardiosis 169.91 10.42 78 176965 489 29396995
Dizziness 169.45 10.42 576 176467 189108 29208376
Toxicity to various agents 165.75 10.42 512 176531 173149 29224335
Disseminated intravascular coagulation 164.24 10.42 367 176676 19613 29377871
Acquired gene mutation 158.46 10.42 97 176946 1161 29396323
BK virus infection 158.40 10.42 167 176876 4540 29392944
Epstein-Barr virus associated lymphoproliferative disorder 155.14 10.42 108 176935 1630 29395854
Cryptococcosis 155.12 10.42 113 176930 1839 29395645
Cytomegalovirus viraemia 154.53 10.42 190 176853 6130 29391354
Steroid diabetes 152.54 10.42 106 176937 1595 29395889
Cardiac failure congestive 147.97 10.42 144 176899 76437 29321047
Cytomegalovirus infection reactivation 145.86 10.42 137 176906 3227 29394257
Hepatic function abnormal 144.51 10.42 540 176503 38719 29358765
Immunosuppressant drug level increased 142.76 10.42 159 176884 4606 29392878
Polyomavirus viraemia 142.10 10.42 72 176971 577 29396907
Cytomegalovirus colitis 141.94 10.42 118 176925 2351 29395133
Pain 140.19 10.42 540 176503 170892 29226592
Feeling abnormal 138.00 10.42 77 176966 54368 29343116
Progressive multifocal leukoencephalopathy 137.41 10.42 212 176831 8507 29388977
Renal impairment 137.23 10.42 895 176148 80438 29317046
Posterior reversible encephalopathy syndrome 135.54 10.42 214 176829 8762 29388722
Disease recurrence 131.56 10.42 293 176750 15621 29381863
Chorioretinopathy 128.76 10.42 89 176954 1327 29396157
Sepsis 124.67 10.42 1354 175689 141328 29256156
Hypogammaglobulinaemia 124.56 10.42 165 176878 5742 29391742
Neutropenic sepsis 124.08 10.42 239 176804 11488 29385996
Pulmonary tuberculosis 122.48 10.42 140 176903 4175 29393309
Mucormycosis 119.59 10.42 151 176892 5007 29392477
Respiratory failure 119.31 10.42 991 176052 96140 29301344
Depression 119.17 10.42 204 176839 84943 29312541
Intentional overdose 118.92 10.42 41 177002 38487 29358997
Cytomegalovirus test positive 117.96 10.42 123 176920 3300 29394184
Somnolence 114.96 10.42 244 176799 93711 29303773
Multiple organ dysfunction syndrome 114.13 10.42 707 176336 62409 29335075
Cushingoid 112.89 10.42 103 176940 2335 29395149
Adenovirus infection 112.46 10.42 136 176907 4311 29393173
Myocardial infarction 109.54 10.42 319 176724 109977 29287507
Bradycardia 108.60 10.42 140 176903 65489 29331995
Viraemia 108.38 10.42 72 176971 1002 29396482
General physical health deterioration 108.01 10.42 1014 176029 101843 29295641
Peripheral swelling 107.51 10.42 134 176909 63605 29333879
Phaeohyphomycosis 104.14 10.42 63 176980 737 29396747
Injection site pain 102.81 10.42 33 177010 32413 29365071
Drug hypersensitivity 102.17 10.42 157 176886 68249 29329235
Hospitalisation 101.59 10.42 76 176967 45912 29351572
Wrong technique in product usage process 101.31 10.42 31 177012 31397 29366087
Insomnia 100.84 10.42 240 176803 88521 29308963
Pneumonia bacterial 99.56 10.42 191 176852 9152 29388332
Blood pressure increased 99.48 10.42 181 176862 73622 29323862
Constipation 98.84 10.42 351 176692 113809 29283675
Disseminated tuberculosis 96.98 10.42 86 176957 1876 29395608
Thrombotic microangiopathy 96.88 10.42 181 176862 8500 29388984
Transplant failure 95.52 10.42 101 176942 2755 29394729
Cerebrovascular accident 94.68 10.42 199 176844 76712 29320772
Confusional state 93.73 10.42 420 176623 127457 29270027
Graft versus host disease 93.14 10.42 189 176854 9439 29388045
Lower respiratory tract infection 92.93 10.42 359 176684 26143 29371341
Cytomegalovirus chorioretinitis 91.81 10.42 105 176938 3133 29394351
Headache 91.36 10.42 638 176405 173369 29224115
Muscle spasms 90.98 10.42 156 176887 64926 29332558
Agitation 89.54 10.42 105 176938 51199 29346285
Leukopenia 88.53 10.42 600 176443 54603 29342881
Pneumonia cytomegaloviral 88.19 10.42 94 176949 2588 29394896
Acute respiratory distress syndrome 88.17 10.42 320 176723 22615 29374869
Osteonecrosis of jaw 87.50 10.42 257 176786 16253 29381231
Brain abscess 83.70 10.42 91 176952 2564 29394920
Unevaluable event 81.93 10.42 38 177005 29813 29367671
Herpes zoster 81.19 10.42 376 176667 29676 29367808
Intentional product misuse 80.87 10.42 54 176989 34607 29362877
Mental status changes 80.70 10.42 55 176988 34872 29362612
Off label use 80.22 10.42 2361 174682 298439 29099045
JC virus infection 79.84 10.42 76 176967 1821 29395663
Disseminated cryptococcosis 79.84 10.42 62 176981 1116 29396368
Blood pressure fluctuation 79.59 10.42 12 177031 19882 29377602
Heart rate decreased 77.76 10.42 26 177017 24886 29372598
Herpes simplex 77.19 10.42 119 176924 4771 29392713
Immunosuppression 77.02 10.42 124 176919 5162 29392322
C-reactive protein increased 76.97 10.42 491 176552 43772 29353712
COVID-19 76.46 10.42 421 176622 35593 29361891
Mycobacterial infection 75.55 10.42 73 176970 1783 29395701
Weight increased 75.16 10.42 223 176820 76444 29321040
Septic shock 74.99 10.42 635 176408 61925 29335559
Dermoid cyst 74.89 10.42 31 177012 145 29397339
Epstein-Barr virus infection reactivation 73.22 10.42 44 176999 508 29396976
Pseudomonas infection 72.57 10.42 184 176859 10668 29386816
Electrocardiogram QT prolonged 72.04 10.42 66 176977 36071 29361413
Suicide attempt 72.00 10.42 59 176984 34051 29363433
Infection reactivation 71.05 10.42 56 176987 1031 29396453
Nephropathy toxic 70.50 10.42 181 176862 10575 29386909
Pneumothorax 70.43 10.42 232 176811 15610 29381874
Loss of personal independence in daily activities 70.41 10.42 32 177011 25408 29372076
Cytomegalovirus enterocolitis 69.03 10.42 49 176994 764 29396720
Neuroleptic malignant syndrome 68.76 10.42 8 177035 16140 29381344
Pain in extremity 68.16 10.42 385 176658 110048 29287436
Blood lactate dehydrogenase increased 67.98 10.42 261 176782 18948 29378536
Varicella zoster virus infection 67.93 10.42 62 176981 1406 29396078
Pneumatosis intestinalis 67.56 10.42 89 176954 3080 29394404
Acinetobacter infection 67.55 10.42 53 176990 969 29396515
Lymphopenia 67.31 10.42 206 176837 13327 29384157
Gait disturbance 67.19 10.42 220 176823 73129 29324355
International normalised ratio increased 67.04 10.42 101 176942 44271 29353213
Blood glucose increased 66.55 10.42 160 176883 58824 29338660
Chronic graft versus host disease 66.35 10.42 100 176943 3929 29393555
Osteoporosis 66.27 10.42 177 176866 10592 29386892
Atypical mycobacterial infection 65.96 10.42 45 176998 656 29396828
Lung abscess 65.86 10.42 76 176967 2290 29395194
Plasma cell myeloma 65.79 10.42 75 176968 37040 29360444
Muscle abscess 65.59 10.42 39 177004 441 29397043
Chronic allograft nephropathy 65.37 10.42 54 176989 1066 29396418
Arthralgia 65.10 10.42 529 176514 139088 29258396
Liver disorder 64.09 10.42 332 176711 27417 29370067
Febrile neutropenia 63.97 10.42 985 176058 111255 29286229
Drug resistance 63.81 10.42 277 176766 21263 29376221
Hepatic failure 63.33 10.42 363 176680 31149 29366335
Weight decreased 63.16 10.42 588 176455 150317 29247167
Hyperhidrosis 62.33 10.42 189 176854 64351 29333133
Memory impairment 62.18 10.42 76 176967 36394 29361090
Lymphocytic infiltration 62.12 10.42 41 177002 564 29396920
Balance disorder 62.07 10.42 75 176968 36095 29361389
Dehydration 61.99 10.42 417 176626 114331 29283153
Trichophytosis 61.76 10.42 31 177012 243 29397241
Pneumocystis jirovecii infection 60.92 10.42 58 176985 1390 29396094
Aggression 60.66 10.42 74 176969 35467 29362017
Tremor 60.38 10.42 231 176812 73307 29324177
Infection 59.96 10.42 713 176330 76038 29321446
Candida infection 59.85 10.42 214 176829 15011 29382473
Diabetes mellitus 59.76 10.42 426 176617 39405 29358079
Obliterative bronchiolitis 59.35 10.42 51 176992 1065 29396419
Upper respiratory tract inflammation 59.05 10.42 60 176983 1560 29395924
Sedation 58.24 10.42 16 177027 17389 29380095
Back pain 58.14 10.42 366 176677 101918 29295566
Incorrect dose administered 58.09 10.42 67 176976 32917 29364567
Visceral leishmaniasis 57.97 10.42 37 177006 479 29397005
Staphylococcal sepsis 57.95 10.42 149 176894 8713 29388771
Immunosuppressant drug level decreased 57.72 10.42 51 176992 1107 29396377
Amnesia 57.38 10.42 32 177011 22611 29374873
Substance-induced psychotic disorder 57.27 10.42 55 176988 1333 29396151
Renal transplant failure 56.55 10.42 47 176996 936 29396548
Pyoderma gangrenosum 56.36 10.42 49 176994 1040 29396444
Inappropriate schedule of product administration 55.60 10.42 114 176929 44358 29353126
Full blood count decreased 54.84 10.42 14 177029 15978 29381506
Pancytopenia 54.53 10.42 748 176295 82420 29315064
Meningitis cryptococcal 54.37 10.42 65 176978 2035 29395449
Pneumonia 54.35 10.42 2388 174655 317784 29079700
Angiocentric lymphoma 54.07 10.42 28 177015 236 29397248
Enterococcal infection 54.05 10.42 139 176904 8129 29389355
Heart rate increased 53.78 10.42 94 176949 38844 29358640
Stress 53.56 10.42 31 177012 21459 29376025
Tuberculosis 53.41 10.42 127 176916 7069 29390415
Pneumomediastinum 53.30 10.42 59 176984 1697 29395787
Escherichia infection 53.07 10.42 122 176921 6642 29390842
Pneumonia cryptococcal 52.94 10.42 41 177002 735 29396749
Diffuse large B-cell lymphoma recurrent 52.39 10.42 71 176972 2526 29394958
Tubulointerstitial nephritis 52.34 10.42 227 176816 17416 29380068
B-cell lymphoma 52.16 10.42 87 176956 3731 29393753
Basal cell carcinoma 52.04 10.42 220 176823 16690 29380794
Bone marrow failure 51.79 10.42 311 176732 27138 29370346
Musculoskeletal stiffness 51.22 10.42 91 176952 37367 29360117
Alveolar proteinosis 51.22 10.42 29 177014 297 29397187
Neutropenia 51.06 10.42 1088 175955 130623 29266861
Parvovirus B19 infection 51.02 10.42 39 177004 685 29396799
Liver transplant rejection 50.95 10.42 61 176982 1913 29395571
Therapy cessation 50.88 10.42 12 177031 14450 29383034
Systemic mycosis 50.12 10.42 50 176993 1271 29396213
Lymphocele 49.77 10.42 50 176993 1282 29396202
Human herpesvirus 8 infection 49.77 10.42 41 177002 806 29396678
Suicidal ideation 49.61 10.42 82 176961 34634 29362850
Sinusitis 49.21 10.42 81 176962 34269 29363215
Product quality issue 48.89 10.42 17 177026 15878 29381606
Unresponsive to stimuli 48.77 10.42 47 176996 25079 29372405
Abdominal discomfort 48.63 10.42 137 176906 47766 29349718
Therapeutic product effect decreased 48.51 10.42 63 176980 29388 29368096
Bacterial infection 48.36 10.42 179 176864 12769 29384715
Cardio-respiratory arrest 48.27 10.42 149 176894 50452 29347032
Heart transplant rejection 48.23 10.42 46 176997 1105 29396379
Fungal infection 47.65 10.42 185 176858 13500 29383984
Organising pneumonia 47.53 10.42 98 176945 4950 29392534
Sweat gland tumour 47.42 10.42 30 177013 382 29397102
Mycobacterium abscessus infection 47.18 10.42 31 177012 423 29397061
Acute graft versus host disease in skin 46.83 10.42 93 176950 4571 29392913
Drug withdrawal syndrome 46.18 10.42 25 177018 17959 29379525
Amoebic colitis 46.09 10.42 18 177025 70 29397414
Epistaxis 46.02 10.42 157 176886 51547 29345937
Delayed graft function 45.61 10.42 57 176986 1870 29395614
Scleroderma renal crisis 45.54 10.42 19 177024 91 29397393
Blood pressure systolic increased 45.36 10.42 22 177021 16823 29380661
Cardiac arrest 45.23 10.42 313 176730 85278 29312206
Foetal growth restriction 45.15 10.42 81 176962 3685 29393799
Proteinuria 45.11 10.42 201 176842 15603 29381881
Drug intolerance 45.06 10.42 144 176899 48235 29349249
Rebound effect 44.79 10.42 58 176985 1973 29395511
Cytomegalovirus oesophagitis 44.68 10.42 29 177014 387 29397097
Encephalitis 44.01 10.42 110 176933 6320 29391164
Intestinal perforation 43.92 10.42 127 176916 7959 29389525
Seizure 43.75 10.42 352 176691 92771 29304713
Fungal endocarditis 43.50 10.42 25 177018 264 29397220
Epstein Barr virus positive mucocutaneous ulcer 43.26 10.42 25 177018 267 29397217
Nephrotic syndrome 43.04 10.42 108 176935 6220 29391264
Kaposi's sarcoma 43.03 10.42 38 177005 824 29396660
Thrombosis 43.03 10.42 124 176919 42921 29354563
Paraesthesia 43.00 10.42 171 176872 53674 29343810
Pleurisy 42.75 10.42 85 176958 4182 29393302
Varicella 42.42 10.42 48 176995 1415 29396069
Contusion 42.10 10.42 76 176967 31019 29366465
Cardiac disorder 42.08 10.42 101 176942 37162 29360322
Infective aneurysm 41.98 10.42 30 177013 473 29397011
Pneumonia fungal 41.84 10.42 101 176942 5676 29391808
Respiratory arrest 41.79 10.42 56 176987 25777 29371707
Joint swelling 41.31 10.42 155 176888 49475 29348009
Pruritus 41.18 10.42 474 176569 116375 29281109
Large intestinal ulcer 41.16 10.42 51 176992 1658 29395826
Actinic keratosis 41.08 10.42 78 176965 3708 29393776
Blood beta-D-glucan increased 41.06 10.42 27 177016 369 29397115
Syncope 40.83 10.42 302 176741 81069 29316415
Atypical femur fracture 40.70 10.42 24 177019 267 29397217
Mycetoma mycotic 40.62 10.42 16 177027 64 29397420
Loss of consciousness 40.52 10.42 268 176775 73788 29323696
Dry skin 40.33 10.42 48 176995 23259 29374225
Hallucination 40.31 10.42 135 176908 44577 29352907
Cerebral aspergillosis 40.19 10.42 45 176998 1311 29396173
Intensive care unit acquired weakness 40.11 10.42 38 177005 905 29396579
Tumour lysis syndrome 39.94 10.42 177 176866 13707 29383777
Small intestinal perforation 39.79 10.42 49 176994 1583 29395901
Squamous cell carcinoma of skin 39.58 10.42 136 176907 9350 29388134
Injection site erythema 39.49 10.42 17 177026 13939 29383545
Peripheral T-cell lymphoma unspecified stage IV 39.49 10.42 13 177030 26 29397458
Gastrointestinal perforation 39.33 10.42 73 176970 3410 29394074
Coma 39.18 10.42 114 176929 39336 29358148
Vomiting 39.02 10.42 970 176073 211290 29186194
Presyncope 38.98 10.42 24 177019 16065 29381419
Focal segmental glomerulosclerosis 38.91 10.42 51 176992 1756 29395728
Intentional self-injury 38.89 10.42 13 177030 12448 29385036
Subcutaneous abscess 38.66 10.42 72 176971 3372 29394112
Osteoporotic fracture 38.51 10.42 38 177005 953 29396531
Listeria sepsis 38.39 10.42 19 177024 144 29397340
Full blood count abnormal 38.36 10.42 21 177022 14992 29382492
Intestinal tuberculosis 38.29 10.42 16 177027 77 29397407
Peritonitis 38.22 10.42 183 176860 14641 29382843
Nasopharyngitis 37.87 10.42 206 176837 59459 29338025
Vasculitis 37.86 10.42 119 176924 7809 29389675
Retinal drusen 37.81 10.42 11 177032 11 29397473
Human herpesvirus 6 infection 37.69 10.42 51 176992 1812 29395672
Accidental exposure to product 37.67 10.42 9 177034 10744 29386740
Lymphoma 37.65 10.42 137 176906 9691 29387793
Cystitis haemorrhagic 37.62 10.42 87 176956 4755 29392729
Chest pain 37.62 10.42 459 176584 111514 29285970
Human polyomavirus infection 37.61 10.42 32 177011 659 29396825
Acute kidney injury 37.49 10.42 1257 175786 264010 29133474
Tendon rupture 37.26 10.42 102 176941 6193 29391291
Mycobacterium chelonae infection 36.92 10.42 30 177013 578 29396906
Viral load increased 36.83 10.42 53 176990 1996 29395488
Diarrhoea 36.83 10.42 1623 175420 331075 29066409
Autoimmune neutropenia 36.68 10.42 22 177021 253 29397231
Lactic acidosis 36.57 10.42 79 176964 30168 29367316
Peripheral T-cell lymphoma unspecified 36.43 10.42 26 177017 409 29397075
Pulmonary fibrosis 36.37 10.42 187 176856 15395 29382089
Low birth weight baby 36.10 10.42 104 176939 6504 29390980
Therapy interrupted 36.09 10.42 4 177039 8382 29389102
Injection site haemorrhage 36.09 10.42 4 177039 8382 29389102
Epstein-Barr virus associated lymphoma 36.03 10.42 29 177014 551 29396933
Adverse drug reaction 35.96 10.42 55 176988 23965 29373519
Poisoning 35.73 10.42 8 177035 9985 29387499
Cerebral venous thrombosis 35.66 10.42 30 177013 608 29396876
Alternaria infection 35.63 10.42 23 177020 304 29397180
Gallbladder rupture 35.53 10.42 27 177016 470 29397014
Gastric disorder 35.51 10.42 10 177033 10694 29386790
Dermatophytosis 35.47 10.42 20 177023 203 29397281
Head injury 34.96 10.42 27 177016 16054 29381430
Serotonin syndrome 34.88 10.42 32 177011 17480 29380004
Coronary artery disease 34.86 10.42 141 176902 44049 29353435
Condition aggravated 34.73 10.42 1133 175910 145162 29252322
Rash 34.72 10.42 868 176175 188951 29208533
Necrotising retinitis 34.69 10.42 32 177011 736 29396748
Therapy partial responder 34.60 10.42 88 176955 5111 29392373
Pneumothorax spontaneous 34.60 10.42 24 177019 360 29397124
Trichophytic granuloma 34.44 10.42 13 177030 45 29397439
Mycoplasma infection 34.39 10.42 22 177021 286 29397198
Gastrooesophageal reflux disease 34.29 10.42 87 176956 31409 29366075
Miosis 34.02 10.42 4 177039 8005 29389479
Hypersomnia 33.95 10.42 11 177032 10743 29386741
Cytomegalovirus gastritis 33.19 10.42 19 177024 199 29397285
Agranulocytosis 33.13 10.42 222 176821 20118 29377366
Subcutaneous emphysema 33.03 10.42 35 177008 957 29396527
Myelosuppression 33.02 10.42 153 176890 12074 29385410
Lung infiltration 33.01 10.42 149 176894 11630 29385854
Adrenal insufficiency 32.97 10.42 143 176900 10971 29386513
Infective spondylitis 32.76 10.42 18 177025 173 29397311
Pseudomembranous colitis 32.61 10.42 57 176986 2540 29394944
Steroid withdrawal syndrome 32.48 10.42 19 177024 208 29397276
Migraine 32.32 10.42 17 177026 12413 29385071
Oesophageal candidiasis 32.30 10.42 71 176972 3750 29393734
Lung consolidation 32.16 10.42 84 176959 4959 29392525
Ileal ulcer 32.00 10.42 26 177017 501 29396983
Myelodysplastic syndrome 31.91 10.42 199 176844 17595 29379889
Cytomegalovirus enteritis 31.86 10.42 24 177019 412 29397072
Orthostatic hypotension 31.82 10.42 54 176989 22575 29374909
Eye infection toxoplasmal 31.82 10.42 18 177025 184 29397300
Body temperature decreased 31.79 10.42 12 177031 10652 29386832
Accidental overdose 31.77 10.42 35 177008 17558 29379926
Hypoalbuminaemia 31.65 10.42 134 176909 10171 29387313
Arthropathy 31.65 10.42 50 176993 21504 29375980
Angiosarcoma 31.59 10.42 20 177023 255 29397229
Road traffic accident 31.51 10.42 28 177015 15533 29381951
Infectious pleural effusion 31.43 10.42 48 176995 1908 29395576
Dyspepsia 31.43 10.42 85 176958 30040 29367444
Tuberculous pleurisy 31.27 10.42 22 177021 338 29397146
Neck pain 31.25 10.42 50 176993 21397 29376087
Blood pressure decreased 31.12 10.42 153 176890 45324 29352160
Graft versus host disease in skin 31.11 10.42 65 176978 3314 29394170
Keratitis bacterial 31.04 10.42 13 177030 63 29397421
Injection site swelling 30.87 10.42 9 177034 9408 29388076
Neuropathy peripheral 30.86 10.42 274 176769 70753 29326731
Myopathy 30.84 10.42 135 176908 10398 29387086
Epstein-Barr virus test positive 30.80 10.42 25 177018 481 29397003
Pulmonary alveolar haemorrhage 30.69 10.42 96 176947 6284 29391200
Bacterial sepsis 30.67 10.42 79 176964 4624 29392860
Cytomegalovirus gastrointestinal ulcer 30.56 10.42 11 177032 32 29397452
Keratitis 30.54 10.42 37 177006 1175 29396309
Colitis ulcerative 30.33 10.42 154 176889 12615 29384869
Hypofibrinogenaemia 30.23 10.42 41 177002 1460 29396024
Acute graft versus host disease 30.22 10.42 90 176953 5734 29391750
Flushing 30.10 10.42 82 176961 28910 29368574
Atrial fibrillation 30.07 10.42 448 176595 105198 29292286
Endophthalmitis 30.07 10.42 58 176985 2790 29394694
Cytomegalovirus gastrointestinal infection 29.87 10.42 17 177026 176 29397308
Haemorrhage subcutaneous 29.81 10.42 49 176994 2076 29395408
Corneal deposits 29.62 10.42 17 177026 179 29397305
Burning sensation 29.57 10.42 31 177012 15907 29381577
Hypoaesthesia 29.49 10.42 193 176850 53274 29344210
Pyelonephritis acute 29.46 10.42 43 177000 1641 29395843
COVID-19 pneumonia 29.39 10.42 124 176919 9398 29388086
Ocular procedural complication 29.36 10.42 12 177031 54 29397430
Cutaneous nocardiosis 29.11 10.42 15 177028 125 29397359
Endocarditis bacterial 28.94 10.42 30 177013 799 29396685
Drug ineffective for unapproved indication 28.72 10.42 164 176879 14050 29383434
Cytomegalovirus gastroenteritis 28.68 10.42 17 177026 191 29397293
Urosepsis 28.68 10.42 134 176909 10612 29386872
Hepatitis fulminant 28.67 10.42 65 176978 3506 29393978
Arthritis bacterial 28.65 10.42 74 176969 4339 29393145
Nervousness 28.61 10.42 16 177027 11290 29386194
Lung transplant rejection 28.58 10.42 28 177015 696 29396788
Hepatitis infectious mononucleosis 28.53 10.42 11 177032 41 29397443
Chest discomfort 28.50 10.42 160 176883 45823 29351661
Nasal congestion 28.48 10.42 43 177000 18836 29378648
Toxoplasmosis 28.39 10.42 35 177008 1132 29396352
Central nervous system lymphoma 28.25 10.42 28 177015 706 29396778
Dyskinesia 28.09 10.42 48 176995 20013 29377471
Staphylococcal infection 28.04 10.42 283 176760 28957 29368527
Hepatosplenomegaly 28.02 10.42 66 176977 3651 29393833
Rhabdomyolysis 28.01 10.42 231 176812 60577 29336907
Chromoblastomycosis 27.93 10.42 11 177032 44 29397440
Blood glucose decreased 27.88 10.42 19 177024 12050 29385434
Gamma-glutamyltransferase increased 27.70 10.42 263 176780 26474 29371010
Corneal lesion 27.67 10.42 9 177034 17 29397467
Varicella zoster pneumonia 27.57 10.42 12 177031 65 29397419
Growth retardation 27.50 10.42 41 177002 1595 29395889
Oxygen saturation decreased 27.50 10.42 157 176886 44780 29352704
Endocarditis 27.48 10.42 86 176957 5630 29391854
Opportunistic infection 27.48 10.42 39 177004 1450 29396034
Enterobacter infection 27.32 10.42 46 176997 1988 29395496
Oesophageal carcinoma 27.24 10.42 74 176969 4473 29393011
Injury 27.19 10.42 45 176998 19001 29378483
Cholangitis 27.15 10.42 103 176940 7434 29390050
Akathisia 27.12 10.42 4 177039 6738 29390746
Plasmablastic lymphoma 27.04 10.42 17 177026 214 29397270
Emotional distress 26.95 10.42 26 177017 13869 29383615
Herpes zoster meningoencephalitis 26.94 10.42 18 177025 253 29397231
Hypoglycaemia 26.92 10.42 174 176869 48172 29349312
Laboratory test abnormal 26.87 10.42 42 177001 18143 29379341
Immune reconstitution inflammatory syndrome 26.78 10.42 105 176938 7697 29389787
Ageusia 26.74 10.42 10 177033 8928 29388556
Pneumonia viral 26.73 10.42 53 176990 2602 29394882
Infection in an immunocompromised host 26.68 10.42 25 177018 587 29396897
Graft loss 26.62 10.42 29 177014 819 29396665
Ureteric stenosis 26.39 10.42 33 177010 1083 29396401
T-cell lymphoma stage IV 26.35 10.42 14 177029 125 29397359
Device malfunction 26.33 10.42 9 177034 8498 29388986
Diffuse large B-cell lymphoma refractory 26.31 10.42 30 177013 892 29396592
Gastritis bacterial 26.24 10.42 16 177027 190 29397294
Systemic infection 26.23 10.42 46 176997 2055 29395429
Hypersensitivity 26.21 10.42 197 176846 52706 29344778
Exposed bone in jaw 26.08 10.42 38 177005 1448 29396036
Sleep disorder 26.05 10.42 68 176975 24318 29373166
Pyelonephritis chronic 25.99 10.42 10 177033 37 29397447
Blood creatine phosphokinase increased 25.96 10.42 140 176903 40504 29356980
Dysgeusia 25.96 10.42 61 176982 22613 29374871
Haematocrit decreased 25.90 10.42 88 176955 28934 29368550
Perinephric abscess 25.78 10.42 10 177033 38 29397446
Underdose 25.71 10.42 20 177023 11849 29385635
Retinal pigment epitheliopathy 25.68 10.42 16 177027 198 29397286
Cutaneous T-cell lymphoma 25.55 10.42 35 177008 1258 29396226
Gingival hypertrophy 25.55 10.42 40 177003 1625 29395859
Dry mouth 25.43 10.42 58 176985 21726 29375758
Tonsillitis 25.33 10.42 44 176999 1951 29395533
Large intestine perforation 25.25 10.42 99 176944 7257 29390227
Amoebiasis 25.21 10.42 11 177032 60 29397424
Polyomavirus test positive 25.16 10.42 13 177030 109 29397375
Medication error 25.15 10.42 56 176987 21155 29376329
Extranodal marginal zone B-cell lymphoma (MALT type) 25.12 10.42 15 177028 171 29397313
Gastroenteritis norovirus 24.94 10.42 36 177007 1360 29396124
Influenza like illness 24.81 10.42 70 176973 24400 29373084
Abdominal distension 24.67 10.42 167 176876 45744 29351740
Nephrolithiasis 24.58 10.42 74 176969 25260 29372224
Cutaneous tuberculosis 24.58 10.42 12 177031 88 29397396
Urticaria 24.56 10.42 209 176834 54451 29343033
Isosporiasis 24.50 10.42 11 177032 65 29397419
Klebsiella infection 24.49 10.42 98 176945 7251 29390233
Sexual dysfunction 24.45 10.42 3 177040 5811 29391673
Acute myeloid leukaemia 24.40 10.42 176 176867 16337 29381147
Irritability 24.26 10.42 61 176982 22091 29375393
Haemoglobin decreased 24.23 10.42 480 176563 107895 29289589
Cardiogenic shock 24.14 10.42 49 176994 19141 29378343
Factitious disorder 24.12 10.42 10 177033 47 29397437
Psoriasis 24.07 10.42 105 176938 32122 29365362
Malacoplakia gastrointestinal 24.02 10.42 12 177031 93 29397391
Peliosis hepatis 23.95 10.42 10 177033 48 29397436
Hyperglycaemia 23.94 10.42 312 176731 33975 29363509
Systemic candida 23.89 10.42 52 176991 2728 29394756
Pneumonitis 23.87 10.42 265 176778 27779 29369705
Heart rate irregular 23.79 10.42 26 177017 13091 29384393
Liver abscess 23.79 10.42 58 176985 3280 29394204
Rhinorrhoea 23.76 10.42 59 176984 21460 29376024
Cerebral infarction 23.74 10.42 239 176804 24436 29373048
Second primary malignancy 23.63 10.42 91 176952 6614 29390870
Hyperplasia 23.53 10.42 22 177021 515 29396969
Erectile dysfunction 23.50 10.42 45 176998 17964 29379520
Injection site bruising 23.50 10.42 8 177035 7572 29389912
Sinusitis aspergillus 23.44 10.42 11 177032 73 29397411
Myelitis 23.43 10.42 25 177018 689 29396795
Glomerulonephritis membranous 23.42 10.42 29 177014 942 29396542
Renal graft infection 23.41 10.42 16 177027 234 29397250
Gastroenteritis adenovirus 23.39 10.42 13 177030 128 29397356
Splenic abscess 23.32 10.42 18 177025 321 29397163
Subdural haematoma 23.27 10.42 46 176997 18147 29379337
Fear 23.27 10.42 14 177029 9490 29387994
Epstein-Barr virus antibody positive 23.26 10.42 17 177026 278 29397206
Kidney fibrosis 23.24 10.42 43 177000 2004 29395480
Meningitis listeria 23.21 10.42 19 177024 370 29397114
Bronchiectasis 22.91 10.42 89 176954 6496 29390988
Pouchitis 22.89 10.42 23 177020 590 29396894
Uveitis 22.86 10.42 83 176960 5864 29391620
Throat irritation 22.86 10.42 12 177031 8773 29388711
Parvovirus infection 22.83 10.42 20 177023 429 29397055
Enterovesical fistula 22.82 10.42 23 177020 592 29396892
Skin necrosis 22.81 10.42 74 176969 4938 29392546
Salivary hypersecretion 22.66 10.42 8 177035 7401 29390083
Rash pruritic 22.65 10.42 64 176979 22299 29375185
Pancreas transplant rejection 22.56 10.42 14 177029 172 29397312
Oral candidiasis 22.51 10.42 125 176918 10597 29386887
Glomerulonephritis membranoproliferative 22.50 10.42 19 177024 387 29397097
Injection site mass 22.50 10.42 3 177040 5452 29392032
Mantle cell lymphoma refractory 22.49 10.42 11 177032 81 29397403
Lymphadenopathy 22.38 10.42 239 176804 24810 29372674
Hernia 22.38 10.42 11 177032 8347 29389137
Molluscum contagiosum 22.35 10.42 16 177027 253 29397231
Oesophageal perforation 22.28 10.42 25 177018 730 29396754
Granuloma 22.22 10.42 47 176996 2417 29395067
Pyelonephritis 22.22 10.42 77 176966 5316 29392168
Concomitant disease aggravated 22.21 10.42 73 176970 4905 29392579
Respiratory depression 22.19 10.42 29 177014 13494 29383990
Product administration error 22.16 10.42 32 177011 14278 29383206
Abnormal behaviour 22.11 10.42 68 176975 23059 29374425
Intraocular pressure increased 22.06 10.42 71 176972 4718 29392766
Trichosporon infection 22.06 10.42 23 177020 617 29396867
Inferior vena cava stenosis 22.05 10.42 8 177035 24 29397460
Mediastinal abscess 22.05 10.42 8 177035 24 29397460
B-lymphocyte count decreased 22.00 10.42 21 177022 505 29396979
Pleural effusion 21.99 10.42 575 176468 71333 29326151
Hypervolaemia 21.90 10.42 45 176998 17500 29379984
T-cell lymphoma 21.88 10.42 27 177016 874 29396610
C-reactive protein abnormal 21.88 10.42 6 177037 6530 29390954
Pneumonia pneumococcal 21.81 10.42 38 177005 1689 29395795
Pneumoperitoneum 21.70 10.42 36 177007 1537 29395947
Injection site reaction 21.63 10.42 21 177022 11167 29386317
Infertility 21.62 10.42 14 177029 186 29397298
Oral herpes 21.62 10.42 68 176975 4464 29393020
Enterococcal sepsis 21.56 10.42 35 177008 1467 29396017
Gallbladder disorder 21.55 10.42 4 177039 5696 29391788
Guillain-Barre syndrome 21.53 10.42 73 176970 4985 29392499
Muscle rigidity 21.49 10.42 15 177028 9396 29388088
Ocular hypertension 21.47 10.42 24 177019 698 29396786
Escherichia sepsis 21.42 10.42 62 176981 3887 29393597
Mycobacterium avium complex infection 21.30 10.42 44 176999 2225 29395259
Lupus nephritis 21.23 10.42 15 177028 232 29397252
Genitourinary tract infection 21.21 10.42 11 177032 93 29397391
Meningoencephalitis viral 21.18 10.42 12 177031 123 29397361
Retinal detachment 21.16 10.42 69 176974 4617 29392867
Dengue fever 21.12 10.42 14 177029 194 29397290
Gastroenteritis sapovirus 21.10 10.42 12 177031 124 29397360
Sphincter of Oddi dysfunction 21.10 10.42 12 177031 124 29397360
Adult T-cell lymphoma/leukaemia 21.10 10.42 12 177031 124 29397360
Cystitis escherichia 21.06 10.42 13 177030 158 29397326
Herpes simplex test positive 21.00 10.42 14 177029 196 29397288
Prostatic specific antigen increased 20.98 10.42 138 176905 12426 29385058
Moraxella infection 20.94 10.42 14 177029 197 29397287
Glomerulonephritis 20.94 10.42 37 177006 1663 29395821
Back disorder 20.92 10.42 5 177038 5968 29391516
Spinal compression fracture 20.90 10.42 82 176961 6012 29391472
Psoas abscess 20.85 10.42 21 177022 540 29396944
Gallbladder necrosis 20.79 10.42 9 177034 48 29397436
B-cell lymphoma recurrent 20.78 10.42 22 177021 601 29396883
Vision blurred 20.67 10.42 148 176895 40028 29357456
Polyglandular autoimmune syndrome type III 20.62 10.42 5 177038 0 29397484
Skin striae 20.49 10.42 19 177024 440 29397044
B-cell lymphoma refractory 20.46 10.42 12 177031 132 29397352
Mycobacterium fortuitum infection 20.39 10.42 13 177030 168 29397316
Cerebral salt-wasting syndrome 20.35 10.42 9 177034 51 29397433
Lymphoplasmacytoid lymphoma/immunocytoma 20.31 10.42 8 177035 32 29397452
Scrotal ulcer 20.23 10.42 17 177026 344 29397140
Superior sagittal sinus thrombosis 20.19 10.42 15 177028 252 29397232
Diarrhoea haemorrhagic 20.11 10.42 79 176964 5795 29391689
Herpes zoster oticus 20.08 10.42 11 177032 105 29397379
Pneumonia legionella 20.08 10.42 35 177008 1556 29395928
Encephalitis Japanese B 20.07 10.42 7 177036 18 29397466
Xanthogranuloma 20.07 10.42 9 177034 53 29397431
Facial paresis 20.02 10.42 47 176996 2594 29394890
Candida pneumonia 20.01 10.42 16 177027 301 29397183
Cataract subcapsular 19.98 10.42 17 177026 350 29397134
IgA nephropathy 19.95 10.42 28 177015 1030 29396454
Neutrophil count decreased 19.89 10.42 369 176674 43198 29354286
Scedosporium infection 19.84 10.42 24 177019 761 29396723
Hydronephrosis 19.84 10.42 104 176939 8626 29388858
Complications of transplanted lung 19.81 10.42 13 177030 177 29397307
Hydrocephalus 19.80 10.42 64 176979 4263 29393221
Lepromatous leprosy 19.79 10.42 9 177034 55 29397429
Pustular psoriasis 19.69 10.42 34 177009 1500 29395984
Complications of transplanted liver 19.68 10.42 14 177029 219 29397265
Sleep apnoea syndrome 19.63 10.42 48 176995 17551 29379933
Bone abscess 19.62 10.42 13 177030 180 29397304
Central nervous system infection 19.62 10.42 20 177023 522 29396962
Intestinal ulcer 19.59 10.42 24 177019 771 29396713
Ecthyma 19.59 10.42 17 177026 360 29397124
Atypical pneumonia 19.57 10.42 46 176997 2541 29394943
Renal adenoma 19.54 10.42 7 177036 20 29397464
Dermatophytosis of nail 19.53 10.42 9 177034 57 29397427
Empyema 19.50 10.42 48 176995 2731 29394753
Graft versus host disease in gastrointestinal tract 19.49 10.42 53 176990 3205 29394279
Cytomegalovirus nephritis 19.48 10.42 11 177032 112 29397372
Herpes simplex hepatitis 19.44 10.42 10 177033 83 29397401
H1N1 influenza 19.43 10.42 25 177018 845 29396639
Myasthenia gravis crisis 19.40 10.42 19 177024 472 29397012
Ureteric obstruction 19.34 10.42 29 177014 1134 29396350
Treatment noncompliance 19.29 10.42 77 176966 24150 29373334
Symptom masked 19.28 10.42 20 177023 533 29396951
Intervertebral disc degeneration 19.26 10.42 4 177039 5260 29392224
Squamous cell carcinoma 19.24 10.42 116 176927 10135 29387349
Gastroenteritis bacterial 19.23 10.42 8 177035 38 29397446
Blood pressure diastolic decreased 19.17 10.42 9 177034 7013 29390471
Impaired healing 19.17 10.42 143 176900 13415 29384069
Drug dependence 19.14 10.42 63 176980 20918 29376566
Ejection fraction decreased 19.09 10.42 42 177001 15936 29381548
Necrotising scleritis 19.06 10.42 8 177035 39 29397445
Restrictive allograft syndrome 19.05 10.42 7 177036 22 29397462
Leukaemic infiltration 19.04 10.42 10 177033 87 29397397
Pollakiuria 18.98 10.42 46 176997 16870 29380614
Incorrect route of product administration 18.95 10.42 22 177021 10779 29386705
Sinus bradycardia 18.92 10.42 25 177018 11578 29385906
Disseminated varicella zoster virus infection 18.89 10.42 12 177031 154 29397330
Chronic inflammatory demyelinating polyradiculoneuropathy 18.89 10.42 21 177022 607 29396877
Tularaemia 18.85 10.42 10 177033 89 29397395
Polyneuropathy 18.81 10.42 131 176912 12021 29385463
Glomerulonephritis proliferative 18.80 10.42 13 177030 194 29397290
Paresis 18.65 10.42 37 177006 1817 29395667
Papilloma viral infection 18.61 10.42 18 177025 440 29397044
Adenoviral haemorrhagic cystitis 18.61 10.42 17 177026 386 29397098
Poikiloderma 18.56 10.42 12 177031 159 29397325
Fungal skin infection 18.53 10.42 43 177000 2355 29395129
Cutaneous malacoplakia 18.43 10.42 8 177035 43 29397441
Leukoencephalopathy 18.41 10.42 57 176986 3710 29393774
Pulmonary air leakage 18.38 10.42 11 177032 126 29397358
Hepatic atrophy 18.37 10.42 12 177031 162 29397322
Listeriosis 18.37 10.42 25 177018 893 29396591
Cryptococcal cutaneous infection 18.32 10.42 9 177034 67 29397417
Discomfort 18.31 10.42 38 177005 14725 29382759
West Nile viral infection 18.29 10.42 21 177022 629 29396855
Spleen atrophy 18.29 10.42 5 177038 3 29397481
Cytomegalovirus hepatitis 18.29 10.42 15 177028 293 29397191
Erythema multiforme 18.27 10.42 93 176950 7624 29389860
Feeling hot 18.27 10.42 41 177002 15447 29382037
Hospice care 18.24 10.42 4 177039 5064 29392420
Therapy non-responder 18.23 10.42 273 176770 30638 29366846
Cyclosporidium infection 18.23 10.42 6 177037 12 29397472
Myelopathy 18.21 10.42 38 177005 1936 29395548
Labelled drug-drug interaction medication error 18.20 10.42 130 176913 12029 29385455
Pneumococcal infection 18.12 10.42 16 177027 347 29397137
Dystonia 18.04 10.42 19 177024 9730 29387754
Product complaint 18.02 10.42 5 177038 5400 29392084
Respiratory alkalosis 17.91 10.42 32 177011 1451 29396033
Skin erosion 17.89 10.42 35 177008 1701 29395783
Sudden hearing loss 17.88 10.42 23 177020 777 29396707
Scleritis 17.79 10.42 15 177028 305 29397179
No adverse event 17.72 10.42 50 176993 17428 29380056
Skin papilloma 17.71 10.42 35 177008 1714 29395770
Central nervous system immune reconstitution inflammatory response 17.61 10.42 6 177037 14 29397470
Acute interstitial pneumonitis 17.60 10.42 16 177027 361 29397123
Hepatic infection fungal 17.59 10.42 12 177031 175 29397309
Microsporum infection 17.58 10.42 7 177036 29 29397455
Meningitis bacterial 17.56 10.42 27 177016 1080 29396404
Mononeuropathy multiplex 17.53 10.42 11 177032 138 29397346
Biopsy kidney abnormal 17.45 10.42 10 177033 105 29397379
Malabsorption 17.39 10.42 37 177006 1911 29395573
Renal tubular atrophy 17.37 10.42 26 177017 1015 29396469
Pneumonia acinetobacter 17.37 10.42 9 177034 76 29397408
Pulpitis dental 17.31 10.42 16 177027 369 29397115
Cellulitis gangrenous 17.24 10.42 12 177031 181 29397303
Respiratory tract infection 17.24 10.42 156 176887 15495 29381989
Microsporidia infection 17.23 10.42 19 177024 544 29396940
Cow pox 17.21 10.42 7 177036 31 29397453
Hemianopia heteronymous 17.21 10.42 7 177036 31 29397453
Lymph node tuberculosis 17.21 10.42 17 177026 427 29397057
Anogenital warts 17.18 10.42 19 177024 546 29396938
Erysipelas 17.13 10.42 60 176983 4165 29393319
Bulbar palsy 17.12 10.42 13 177030 226 29397258
Ear infection 17.10 10.42 14 177029 8086 29389398
Toxic epidermal necrolysis 17.07 10.42 175 176868 17978 29379506
Cytomegalovirus duodenitis 17.06 10.42 8 177035 53 29397431
Argentine haemorrhagic fever 17.05 10.42 6 177037 16 29397468
Neurofibrosarcoma 17.04 10.42 7 177036 32 29397452
Extrapyramidal disorder 16.99 10.42 24 177019 10807 29386677
Bone tuberculosis 16.96 10.42 15 177028 326 29397158
Mobility decreased 16.91 10.42 88 176955 25692 29371792
Cytopenia 16.90 10.42 109 176934 9750 29387734
Gait inability 16.89 10.42 55 176988 18320 29379164
Tubulointerstitial nephritis and uveitis syndrome 16.88 10.42 9 177034 81 29397403
Product substitution issue 16.84 10.42 18 177025 9154 29388330
Adverse event 16.82 10.42 42 177001 15249 29382235
Abscess fungal 16.81 10.42 11 177032 149 29397335
Blood triglycerides increased 16.81 10.42 32 177011 12802 29384682
Chronic myeloid leukaemia 16.80 10.42 37 177006 1957 29395527
Interleukin level increased 16.79 10.42 9 177034 82 29397402
Ileal stenosis 16.78 10.42 28 177015 1201 29396283
Epidural lipomatosis 16.78 10.42 21 177022 690 29396794
Cerebral venous sinus thrombosis 16.72 10.42 16 177027 386 29397098
Gallbladder oedema 16.70 10.42 12 177031 191 29397293
Gastric perforation 16.68 10.42 39 177004 2147 29395337
Acanthosis 16.67 10.42 10 177033 115 29397369
Pancreatic enzymes increased 16.66 10.42 19 177024 565 29396919
Product storage error 16.60 10.42 9 177034 6461 29391023
Neutrophil morphology abnormal 16.58 10.42 8 177035 57 29397427
Graft versus host disease in liver 16.54 10.42 26 177017 1060 29396424
Protothecosis 16.54 10.42 7 177036 35 29397449
Alpha tumour necrosis factor increased 16.50 10.42 4 177039 0 29397484
Alcohol abuse 16.47 10.42 3 177040 4330 29393154
Limb injury 16.47 10.42 19 177024 9336 29388148
Exophthalmos 16.36 10.42 18 177025 514 29396970
Meningitis 16.32 10.42 60 176983 4265 29393219
Coronary artery bypass 16.26 10.42 4 177039 4681 29392803
Melanaemia 16.23 10.42 8 177035 60 29397424
Infective tenosynovitis 16.23 10.42 8 177035 60 29397424
Heart block congenital 16.22 10.42 7 177036 37 29397447
Wound infection pseudomonas 16.19 10.42 13 177030 246 29397238
Colitis 16.17 10.42 270 176773 30978 29366506
Post herpetic neuralgia 16.13 10.42 24 177019 932 29396552
Gas gangrene 16.12 10.42 8 177035 61 29397423
Illness 16.10 10.42 10 177033 6664 29390820
Monocyte percentage decreased 16.07 10.42 7 177036 38 29397446
Continuous haemodiafiltration 16.05 10.42 24 177019 936 29396548
Gastric cancer 16.03 10.42 64 176979 4730 29392754
Myositis 16.01 10.42 111 176932 10172 29387312
Premature baby 15.97 10.42 166 176877 17114 29380370
Gastrointestinal mucosa hyperaemia 15.93 10.42 13 177030 252 29397232
Skin laceration 15.92 10.42 26 177017 11036 29386448
Intestinal villi atrophy 15.90 10.42 10 177033 126 29397358
Cerebellar infarction 15.89 10.42 34 177009 1763 29395721
Cell marker increased 15.87 10.42 16 177027 412 29397072
Pulmonary vasculitis 15.83 10.42 10 177033 127 29397357
Decreased appetite 15.79 10.42 710 176333 144632 29252852
Attention-seeking behaviour 15.78 10.42 7 177036 40 29397444
Purpura 15.78 10.42 102 176941 9130 29388354
Urinary tract infection bacterial 15.77 10.42 30 177013 1428 29396056
Obstructive airways disorder 15.75 10.42 26 177017 10990 29386494
Multimorbidity 15.74 10.42 18 177025 537 29396947
International normalised ratio decreased 15.71 10.42 3 177040 4187 29393297
Acute myocardial infarction 15.70 10.42 200 176843 48238 29349246
Bronchial carcinoma 15.69 10.42 23 177020 881 29396603
Inflammatory marker increased 15.67 10.42 53 176990 3614 29393870
Disseminated strongyloidiasis 15.66 10.42 9 177034 95 29397389
Psoriatic arthropathy 15.66 10.42 41 177002 14650 29382834
Granulomatosis with polyangiitis 15.65 10.42 23 177020 883 29396601
VIth nerve paresis 15.64 10.42 7 177036 41 29397443
Phaeohyphomycotic brain abscess 15.64 10.42 7 177036 41 29397443
Chronic hepatitis 15.63 10.42 18 177025 541 29396943
Hypochromic anaemia 15.58 10.42 21 177022 743 29396741
Mantle cell lymphoma recurrent 15.58 10.42 17 177026 481 29397003
Nocardia sepsis 15.53 10.42 5 177038 9 29397475
Abdominal tenderness 15.51 10.42 52 176991 3530 29393954
Cholangitis sclerosing 15.50 10.42 25 177018 1042 29396442
Acute hepatitis B 15.50 10.42 10 177033 132 29397352
Meningoencephalitis herpetic 15.48 10.42 21 177022 748 29396736
Osteoarthritis 15.41 10.42 56 176987 18047 29379437
Multiple sclerosis relapse 15.37 10.42 28 177015 11391 29386093
Fusarium infection 15.37 10.42 24 177019 973 29396511
Soft tissue mass 15.35 10.42 19 177024 617 29396867
Obesity 15.33 10.42 22 177021 9841 29387643
Oesophageal fibrosis 15.31 10.42 11 177032 175 29397309
Throat tightness 15.29 10.42 12 177031 7079 29390405
Dental fistula 15.27 10.42 9 177034 100 29397384
IVth nerve paralysis 15.27 10.42 9 177034 100 29397384
Substance abuse 15.26 10.42 11 177032 6776 29390708
Mediastinitis 15.23 10.42 19 177024 622 29396862
Acute hepatic failure 15.20 10.42 123 176920 11829 29385655
Prescribed underdose 15.18 10.42 89 176954 7697 29389787
Cerebral toxoplasmosis 15.15 10.42 29 177014 1387 29396097
Gastrointestinal wall thickening 15.14 10.42 26 177017 1142 29396342
Infected skin ulcer 15.13 10.42 29 177014 1388 29396096
Necrosis 15.13 10.42 65 176978 4965 29392519
Acute biphenotypic leukaemia 15.10 10.42 8 177035 71 29397413
Mouth ulceration 15.08 10.42 110 176933 10245 29387239
Myoclonus 15.08 10.42 36 177007 13273 29384211
Pseudarthrosis 15.01 10.42 8 177035 72 29397412
Respiratory rate increased 14.99 10.42 18 177025 8690 29388794
Therapeutic response shortened 14.95 10.42 5 177038 4786 29392698
Retinitis 14.91 10.42 13 177030 277 29397207
Prescribed overdose 14.89 10.42 18 177025 8665 29388819
Acute monocytic leukaemia 14.89 10.42 14 177029 330 29397154
Hypomagnesaemia 14.89 10.42 54 176989 17414 29380070
Dysarthria 14.89 10.42 116 176927 30795 29366689
Smooth muscle cell neoplasm 14.88 10.42 10 177033 142 29397342
Renal abscess 14.84 10.42 11 177032 184 29397300
Rheumatoid factor 14.82 10.42 8 177035 74 29397410
Sinusitis fungal 14.79 10.42 15 177028 389 29397095
Seasonal allergy 14.78 10.42 6 177037 5096 29392388
Polychondritis 14.76 10.42 10 177033 144 29397340
Visual acuity reduced 14.75 10.42 145 176898 14731 29382753
Coronary artery aneurysm 14.73 10.42 8 177035 75 29397409
Metastatic carcinoma of the bladder 14.70 10.42 10 177033 145 29397339
Aortic aneurysm rupture 14.70 10.42 23 177020 934 29396550
Alanine aminotransferase increased 14.68 10.42 541 176502 70403 29327081
Mycobacterium kansasii infection 14.65 10.42 12 177031 234 29397250
Nerve conduction studies abnormal 14.61 10.42 7 177036 49 29397435
Steroid dependence 14.60 10.42 13 177030 285 29397199
Rectosigmoid cancer 14.59 10.42 10 177033 147 29397337
Intervertebral discitis 14.58 10.42 32 177011 1688 29395796
Splenic neoplasm malignancy unspecified 14.57 10.42 5 177038 12 29397472
Fundoscopy abnormal 14.57 10.42 5 177038 12 29397472
Candida sepsis 14.56 10.42 25 177018 1098 29396386
Middle insomnia 14.56 10.42 8 177035 5700 29391784
Haemolytic uraemic syndrome 14.52 10.42 35 177008 1965 29395519
Hepatitis 14.45 10.42 189 176854 20594 29376890
Connective tissue disorder 14.45 10.42 11 177032 192 29397292
Eosinophilic granulomatosis with polyangiitis 14.36 10.42 28 177015 1358 29396126
New onset diabetes after transplantation 14.34 10.42 6 177037 29 29397455
Serous retinal detachment 14.31 10.42 15 177028 405 29397079
Relapsing fever 14.30 10.42 10 177033 152 29397332
Retroperitoneal neoplasm 14.30 10.42 5 177038 13 29397471
Abdominal pain upper 14.27 10.42 268 176775 60725 29336759
Erythema infectiosum 14.25 10.42 10 177033 153 29397331
Epididymitis 14.23 10.42 37 177006 2178 29395306
Non-cirrhotic portal hypertension 14.23 10.42 12 177031 244 29397240
Septic encephalopathy 14.21 10.42 8 177035 81 29397403
Autoimmune haemolytic anaemia 14.20 10.42 53 176990 3795 29393689
Metastasis 14.16 10.42 49 176994 3380 29394104
Mouth swelling 14.14 10.42 30 177013 1546 29395938
Pathogen resistance 14.07 10.42 90 176953 8026 29389458
Prostatic abscess 14.07 10.42 15 177028 413 29397071
Oropharyngeal pain 14.05 10.42 110 176933 29175 29368309
Porokeratosis 14.04 10.42 8 177035 83 29397401
Diffuse alveolar damage 14.03 10.42 35 177008 2008 29395476
Acanthoma 14.02 10.42 6 177037 31 29397453
Complications of transplanted heart 13.99 10.42 12 177031 250 29397234
Osteomyelitis bacterial 13.99 10.42 13 177030 302 29397182
Giant cell arteritis 13.96 10.42 20 177023 750 29396734
Norovirus test positive 13.93 10.42 7 177036 55 29397429
Loss of proprioception 13.90 10.42 14 177029 360 29397124
Removal of renal transplant 13.86 10.42 6 177037 32 29397452
Transient ischaemic attack 13.86 10.42 82 176961 23188 29374296
Pulmonary sepsis 13.83 10.42 33 177010 1841 29395643
Herpes zoster cutaneous disseminated 13.82 10.42 10 177033 161 29397323
Phlebitis infective 13.81 10.42 9 177034 121 29397363
Renal tubular injury 13.79 10.42 19 177024 687 29396797
Pyuria 13.77 10.42 18 177025 618 29396866
Lumbar vertebral fracture 13.75 10.42 32 177011 1756 29395728
Neonatal lupus erythematosus 13.75 10.42 4 177039 4 29397480
Bone marrow necrosis 13.75 10.42 9 177034 122 29397362
Physical deconditioning 13.75 10.42 20 177023 761 29396723
Calciphylaxis 13.74 10.42 23 177020 989 29396495
Emphysema 13.73 10.42 94 176949 8577 29388907
Myocardial calcification 13.71 10.42 6 177037 33 29397451
Viral cardiomyopathy 13.71 10.42 6 177037 33 29397451
Citrobacter infection 13.67 10.42 15 177028 427 29397057
Capnocytophaga infection 13.62 10.42 7 177036 58 29397426
Diffuse large B-cell lymphoma stage III 13.62 10.42 7 177036 58 29397426
DNA antibody positive 13.62 10.42 7 177036 58 29397426
Rectal cancer 13.62 10.42 33 177010 1859 29395625
Mental impairment 13.61 10.42 21 177022 9120 29388364
Hepatic cytolysis 13.59 10.42 18 177025 8329 29389155
Gastrointestinal erosion 13.59 10.42 14 177029 370 29397114
Anorectal varices 13.57 10.42 6 177037 34 29397450
Glomerulonephritis rapidly progressive 13.53 10.42 16 177027 495 29396989
Spindle cell sarcoma 13.50 10.42 9 177034 126 29397358
Glomerulosclerosis 13.50 10.42 19 177024 701 29396783
Tinnitus 13.49 10.42 48 176995 15566 29381918
Priapism 13.46 10.42 5 177038 4483 29393001
Euphoric mood 13.46 10.42 6 177037 4819 29392665
Angina unstable 13.45 10.42 28 177015 10837 29386647
Pneumaturia 13.42 10.42 6 177037 35 29397449
Liver transplant failure 13.41 10.42 8 177035 91 29397393
Seroma 13.41 10.42 17 177026 566 29396918
Arteriosclerosis coronary artery 13.41 10.42 27 177016 10578 29386906
Glucose tolerance impaired 13.40 10.42 42 177001 2752 29394732
Retinal haemorrhage 13.39 10.42 58 176985 4446 29393038
Skin lesion 13.38 10.42 170 176873 18402 29379082
Coronary artery occlusion 13.37 10.42 25 177018 10069 29387415
Hepatic amoebiasis 13.32 10.42 7 177036 61 29397423
Cardiac autonomic neuropathy 13.32 10.42 7 177036 61 29397423
Bursitis infective 13.31 10.42 16 177027 504 29396980
Pyomyositis 13.26 10.42 9 177034 130 29397354
Post procedural bile leak 13.22 10.42 12 177031 270 29397214
Respiratory tract haemorrhage 13.21 10.42 22 177021 942 29396542
Ventricular tachycardia 13.20 10.42 80 176963 22494 29374990
Fungal abscess central nervous system 13.19 10.42 8 177035 94 29397390
Lung adenocarcinoma 13.18 10.42 52 176991 3823 29393661
Tooth disorder 13.16 10.42 23 177020 9506 29387978
N-telopeptide urine increased 13.15 10.42 6 177037 37 29397447
Failure to thrive 13.11 10.42 16 177027 7668 29389816
Papillary renal cell carcinoma 13.03 10.42 9 177034 134 29397350
Rectal perforation 13.03 10.42 14 177029 389 29397095
Megakaryocytes increased 13.02 10.42 6 177037 38 29397446
Hip fracture 13.02 10.42 27 177016 10465 29387019
Gastroenteritis 13.01 10.42 124 176919 12492 29384992
Alveolitis 13 10.42 29 177014 1547 29395937
Blindness cortical 12.98 10.42 13 177030 332 29397152
Chronic graft versus host disease in skin 12.95 10.42 20 177023 803 29396681
Anal abscess 12.94 10.42 64 176979 5187 29392297
Sinus disorder 12.94 10.42 10 177033 5945 29391539
Metastases to lymph nodes 12.93 10.42 53 176990 3964 29393520
Henoch-Schonlein purpura 12.92 10.42 26 177017 1290 29396194
T-lymphocyte count decreased 12.92 10.42 10 177033 179 29397305
Mycobacterium marinum infection 12.90 10.42 12 177031 279 29397205
Speech disorder 12.90 10.42 85 176958 23431 29374053
VIth nerve paralysis 12.88 10.42 19 177024 732 29396752
Aplasia pure red cell 12.88 10.42 66 176977 5425 29392059
Adrenocortical insufficiency acute 12.87 10.42 26 177017 1294 29396190
Chlamydia test positive 12.87 10.42 4 177039 6 29397478
Adrenal atrophy 12.87 10.42 4 177039 6 29397478
Histiocytosis 12.87 10.42 4 177039 6 29397478
Zika virus infection 12.87 10.42 4 177039 6 29397478
Acquired porokeratosis 12.87 10.42 4 177039 6 29397478
Cognitive disorder 12.86 10.42 85 176958 23414 29374070
Nightmare 12.84 10.42 31 177012 11386 29386098
Eructation 12.82 10.42 4 177039 4002 29393482
Immunodeficiency common variable 12.81 10.42 9 177034 138 29397346
Osteomyelitis fungal 12.79 10.42 11 177032 230 29397254
Neurodermatitis 12.79 10.42 11 177032 230 29397254
Eye infection staphylococcal 12.76 10.42 6 177037 40 29397444
Cutaneous T-cell lymphoma recurrent 12.76 10.42 6 177037 40 29397444
Optic discs blurred 12.76 10.42 7 177036 67 29397417
Wound decomposition 12.76 10.42 7 177036 67 29397417
Concomitant disease progression 12.74 10.42 37 177006 2324 29395160
Behaviour disorder 12.72 10.42 3 177040 3613 29393871
Ophthalmic herpes zoster 12.71 10.42 19 177024 741 29396743
Sweat gland disorder 12.70 10.42 8 177035 101 29397383
Infected lymphocele 12.69 10.42 5 177038 20 29397464
Helicobacter sepsis 12.69 10.42 5 177038 20 29397464
Pulmonary artery thrombosis 12.69 10.42 17 177026 598 29396886
Gout 12.69 10.42 55 176988 16856 29380628
Prostatomegaly 12.68 10.42 6 177037 4655 29392829
Proctocolectomy 12.68 10.42 7 177036 68 29397416
Urinary tract obstruction 12.66 10.42 46 176997 3251 29394233
Nocturia 12.65 10.42 19 177024 8343 29389141
Gastrointestinal haemorrhage 12.60 10.42 371 176672 79162 29318322
Engraftment syndrome 12.59 10.42 20 177023 823 29396661
Hepatocellular injury 12.57 10.42 75 176968 21168 29376316
Aortic dissection 12.52 10.42 37 177006 2347 29395137
Haemorrhage 12.51 10.42 192 176851 44880 29352604
Fluid retention 12.50 10.42 86 176957 23474 29374010
Necrotising colitis 12.49 10.42 22 177021 986 29396498
Blood lactate dehydrogenase 12.49 10.42 4 177039 7 29397477
Coinfection 12.49 10.42 4 177039 7 29397477
Myocardiac abscess 12.49 10.42 4 177039 7 29397477
Respiratory tract congestion 12.48 10.42 8 177035 5241 29392243
Blood testosterone decreased 12.44 10.42 4 177039 3926 29393558
Gingival erythema 12.44 10.42 8 177035 105 29397379
Eye abscess 12.43 10.42 9 177034 145 29397339
Aspergilloma 12.42 10.42 12 177031 293 29397191
Dehiscence 12.42 10.42 7 177036 71 29397413
Febrile infection 12.39 10.42 33 177010 1971 29395513
Duodenal perforation 12.39 10.42 24 177019 1158 29396326
Abdominal wall haematoma 12.38 10.42 29 177014 1598 29395886
Bowen's disease 12.38 10.42 9 177034 146 29397338
Microangiopathic haemolytic anaemia 12.38 10.42 20 177023 835 29396649
Splint application 12.37 10.42 3 177040 0 29397484
Phagocytosis 12.37 10.42 3 177040 0 29397484
Hyposplenism 12.37 10.42 3 177040 0 29397484
Pancreatic leak 12.37 10.42 3 177040 0 29397484
Listeraemia 12.37 10.42 3 177040 0 29397484
Nodular vasculitis 12.37 10.42 3 177040 0 29397484
Anorectal infection bacterial 12.37 10.42 3 177040 0 29397484
Skin hyperplasia 12.37 10.42 3 177040 0 29397484
Congenital thrombocytopenia 12.37 10.42 3 177040 0 29397484
Papule 12.36 10.42 45 176998 3184 29394300
Granulocytopenia neonatal 12.32 10.42 5 177038 22 29397462
Brucellosis 12.32 10.42 5 177038 22 29397462
Type 3 diabetes mellitus 12.32 10.42 5 177038 22 29397462
Coronary arterial stent insertion 12.28 10.42 4 177039 3893 29393591
Vasculitic rash 12.27 10.42 20 177023 841 29396643
Antithrombin III decreased 12.26 10.42 12 177031 298 29397186
Blood HIV RNA increased 12.24 10.42 22 177021 1002 29396482
Abnormal dreams 12.24 10.42 14 177029 6906 29390578
Blood urine present 12.19 10.42 25 177018 9730 29387754
Papilloedema 12.18 10.42 36 177007 2284 29395200
Chronic graft versus host disease in eye 12.18 10.42 6 177037 45 29397439
Pulmonary necrosis 12.16 10.42 13 177030 359 29397125
Pseudomonal sepsis 12.12 10.42 42 177001 2900 29394584
Psychomotor hyperactivity 12.10 10.42 19 177024 8194 29389290
Immobilisation syndrome 12.07 10.42 9 177034 152 29397332
Swelling 12.07 10.42 144 176899 35139 29362345
Drug therapeutic incompatibility 12.06 10.42 8 177035 111 29397373
Blood test abnormal 12.06 10.42 10 177033 5739 29391745
Back injury 12.04 10.42 3 177040 3481 29394003
Pustule 12.00 10.42 11 177032 251 29397233
Tuberculosis gastrointestinal 12.00 10.42 10 177033 200 29397284
Eye pain 11.98 10.42 114 176929 11481 29386003
Hypocomplementaemia 11.98 10.42 5 177038 24 29397460
Biopsy site unspecified abnormal 11.98 10.42 5 177038 24 29397460
Non-alcoholic steatohepatitis 11.97 10.42 19 177024 781 29396703
Chylothorax 11.90 10.42 17 177026 636 29396848
Oropharyngeal candidiasis 11.90 10.42 17 177026 636 29396848
Encapsulating peritoneal sclerosis 11.90 10.42 16 177027 565 29396919
Interleukin-2 receptor increased 11.88 10.42 8 177035 114 29397370
Pulse absent 11.88 10.42 8 177035 5105 29392379
Haemophilus infection 11.85 10.42 21 177022 946 29396538
Hepatitis B e antigen positive 11.85 10.42 6 177037 48 29397436
Gingival cancer 11.84 10.42 4 177039 9 29397475
Neutrophil percentage abnormal 11.84 10.42 4 177039 9 29397475
Lung squamous cell carcinoma stage I 11.84 10.42 4 177039 9 29397475
Lymphocyte percentage abnormal 11.84 10.42 4 177039 9 29397475
Pityriasis lichenoides et varioliformis acuta 11.84 10.42 4 177039 9 29397475
Mucosal ulceration 11.82 10.42 20 177023 868 29396616
Cystitis viral 11.79 10.42 15 177028 501 29396983
Germ cell cancer 11.78 10.42 7 177036 79 29397405
Cavernous sinus thrombosis 11.78 10.42 9 177034 158 29397326
Paranoia 11.77 10.42 26 177017 9851 29387633
Cranial nerve palsies multiple 11.75 10.42 6 177037 49 29397435
Blood pressure ambulatory increased 11.75 10.42 6 177037 49 29397435
Hypersensitivity pneumonitis 11.71 10.42 25 177018 1294 29396190
Paratracheal lymphadenopathy 11.71 10.42 7 177036 80 29397404
Epstein-Barr viraemia 11.68 10.42 21 177022 957 29396527
CSF glucose decreased 11.65 10.42 5 177038 26 29397458
Typhoid fever 11.65 10.42 5 177038 26 29397458
Pleural adhesion 11.64 10.42 9 177034 161 29397323
Skin discolouration 11.63 10.42 50 176993 15359 29382125
Retinal disorder 11.62 10.42 20 177023 880 29396604
Enterocolitis 11.61 10.42 74 176969 6592 29390892
Reticulocytosis 11.61 10.42 11 177032 262 29397222
Blood alkaline phosphatase abnormal 11.60 10.42 13 177030 379 29397105
Drug withdrawal syndrome neonatal 11.59 10.42 3 177040 3392 29394092
Limb discomfort 11.55 10.42 25 177018 9543 29387941
Hyperglycaemic hyperosmolar nonketotic syndrome 11.55 10.42 22 177021 1048 29396436
Endotoxic shock 11.55 10.42 4 177039 10 29397474
Angioimmunoblastic T-cell lymphoma stage IV 11.55 10.42 4 177039 10 29397474
Lemierre syndrome 11.55 10.42 4 177039 10 29397474
Thyroid stimulating hormone deficiency 11.55 10.42 4 177039 10 29397474
Cardiac myxoma 11.55 10.42 4 177039 10 29397474
Myalgia 11.54 10.42 346 176697 73673 29323811
Pharyngeal ulceration 11.53 10.42 12 177031 321 29397163
Renal infarct 11.53 10.42 23 177020 1134 29396350
Sneezing 11.53 10.42 6 177037 4408 29393076
Wound dehiscence 11.51 10.42 42 177001 2975 29394509
Drug level increased 11.50 10.42 167 176876 18620 29378864
Acid fast bacilli infection 11.49 10.42 7 177036 83 29397401
Red blood cell count decreased 11.45 10.42 98 176945 25504 29371980
Intussusception 11.43 10.42 15 177028 517 29396967
Osteomyelitis 11.42 10.42 129 176914 13580 29383904
Drug level changed 11.42 10.42 12 177031 325 29397159
Blood alkaline phosphatase increased 11.41 10.42 236 176807 28170 29369314
Stenotrophomonas infection 11.36 10.42 29 177014 1688 29395796
Cranial nerve paralysis 11.35 10.42 5 177038 28 29397456
Renal and pancreas transplant rejection 11.35 10.42 5 177038 28 29397456
Asymptomatic viral hepatitis 11.35 10.42 5 177038 28 29397456
Respiratory tract infection fungal 11.35 10.42 17 177026 664 29396820
Neutropenic colitis 11.34 10.42 36 177007 2375 29395109
Escherichia urinary tract infection 11.33 10.42 42 177001 2997 29394487
Oesophageal tuberculosis 11.28 10.42 4 177039 11 29397473
Neisseria infection 11.28 10.42 4 177039 11 29397473
Hepatitis C RNA increased 11.24 10.42 11 177032 273 29397211
Multiple sclerosis 11.24 10.42 10 177033 5544 29391940
Joint stiffness 11.24 10.42 25 177018 9448 29388036
Congenital hepatobiliary anomaly 11.21 10.42 5 177038 29 29397455
Tardive dyskinesia 11.21 10.42 9 177034 5249 29392235
Malignant fibrous histiocytoma 11.21 10.42 7 177036 87 29397397
Pulmonary oedema 11.20 10.42 184 176859 42551 29354933
Renal failure 11.18 10.42 588 176455 118011 29279473
Idiopathic pulmonary fibrosis 11.17 10.42 43 177000 3125 29394359
Optic neuropathy 11.17 10.42 29 177014 1706 29395778
Sarcoidosis 11.14 10.42 38 177005 2602 29394882
Endocarditis enterococcal 11.14 10.42 7 177036 88 29397396
Vitritis 11.13 10.42 17 177026 676 29396808
Rheumatoid vasculitis 11.09 10.42 10 177033 223 29397261
Nephritis 11.08 10.42 33 177010 2103 29395381
Viral uveitis 11.07 10.42 5 177038 30 29397454
Stent placement 11.03 10.42 6 177037 4300 29393184
Peripheral T-cell lymphoma unspecified refractory 11.02 10.42 4 177039 12 29397472
Purulent discharge 11.02 10.42 37 177006 2513 29394971
CD4/CD8 ratio decreased 11.02 10.42 4 177039 12 29397472
Breast discomfort 11.02 10.42 4 177039 12 29397472
Tooth erosion 11.01 10.42 7 177036 90 29397394
Rheumatoid factor increased 11.00 10.42 15 177028 537 29396947
Feeling jittery 10.98 10.42 4 177039 3629 29393855
Psychotic disorder 10.95 10.42 74 176969 20280 29377204
Neuroborreliosis 10.94 10.42 5 177038 31 29397453
Shock haemorrhagic 10.93 10.42 96 176947 9455 29388029
Diverticular perforation 10.93 10.42 41 177002 2943 29394541
Purulence 10.93 10.42 19 177024 843 29396641
Acanthamoeba infection 10.92 10.42 13 177030 405 29397079
Therapeutic response unexpected 10.91 10.42 22 177021 8616 29388868
Metastatic bronchial carcinoma 10.91 10.42 10 177033 228 29397256
Diffuse large B-cell lymphoma stage IV 10.91 10.42 10 177033 228 29397256
Body height below normal 10.91 10.42 10 177033 228 29397256
Pulmonary cavitation 10.91 10.42 18 177025 765 29396719
Oesophagopleural fistula 10.89 10.42 6 177037 58 29397426
Primary biliary cholangitis 10.89 10.42 8 177035 132 29397352
Pancreatic duct stenosis 10.88 10.42 9 177034 178 29397306
Anti-platelet antibody positive 10.84 10.42 10 177033 230 29397254
Idiopathic interstitial pneumonia 10.84 10.42 8 177035 133 29397351
Sensory loss 10.82 10.42 51 176992 4053 29393431
Mood altered 10.82 10.42 20 177023 8091 29389393
Glaucoma 10.81 10.42 66 176977 5791 29391693
Lupus pneumonitis 10.80 10.42 6 177037 59 29397425
Raoultella ornithinolytica infection 10.79 10.42 4 177039 13 29397471
Dyslalia 10.77 10.42 14 177029 478 29397006
Gastroduodenal ulcer 10.76 10.42 12 177031 348 29397136
Xanthelasma 10.75 10.42 7 177036 94 29397390
Gene mutation 10.74 10.42 21 177022 1020 29396464
Superinfection bacterial 10.71 10.42 17 177026 699 29396785
Blood pressure abnormal 10.70 10.42 15 177028 6775 29390709
Klebsiella sepsis 10.69 10.42 28 177015 1656 29395828
Circulatory collapse 10.65 10.42 164 176879 18509 29378975
Gastrointestinal necrosis 10.64 10.42 41 177002 2981 29394503
Haemorrhoids 10.64 10.42 35 177008 11622 29385862
Bone infarction 10.63 10.42 10 177033 236 29397248
Transplantation complication 10.62 10.42 7 177036 96 29397388
Bradyphrenia 10.61 10.42 6 177037 4208 29393276
Small for dates baby 10.57 10.42 46 176997 3533 29393951
Ewing's sarcoma 10.57 10.42 4 177039 14 29397470
Ureteritis 10.57 10.42 4 177039 14 29397470
Paternal exposure timing unspecified 10.55 10.42 5 177038 34 29397450
Duodenal ulcer perforation 10.55 10.42 26 177017 1480 29396004
Salmonella bacteraemia 10.54 10.42 8 177035 139 29397345
Immune thrombocytopenia 10.53 10.42 82 176961 7795 29389689
Demyelinating polyneuropathy 10.52 10.42 22 177021 1122 29396362
Histoplasmosis disseminated 10.52 10.42 22 177021 1122 29396362
Hypersensitivity vasculitis 10.51 10.42 43 177000 3214 29394270
Neurological symptom 10.49 10.42 44 176999 3326 29394158
Pneumonia mycoplasmal 10.44 10.42 15 177028 564 29396920
Granulomatous rosacea 10.44 10.42 8 177035 141 29397343
Restless legs syndrome 10.44 10.42 16 177027 6968 29390516
Ulcerative keratitis 10.44 10.42 25 177018 1398 29396086
Post streptococcal glomerulonephritis 10.43 10.42 5 177038 35 29397449
Influenza 10.43 10.42 182 176861 41699 29355785

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1680.96 9.65 1441 325377 35758 64136156
Pneumocystis jirovecii pneumonia 1604.21 9.65 1239 325579 26395 64145519
Completed suicide 885 9.65 66 326752 224348 63947566
Product use in unapproved indication 861.01 9.65 2395 324423 174223 63997691
Fatigue 720.67 9.65 1719 325099 747011 63424903
Hepatitis B 579.75 9.65 405 326413 7340 64164574
Product dose omission issue 578.42 9.65 138 326680 194609 63977305
Pain 577.16 9.65 1215 325603 552296 63619618
Interstitial lung disease 558.72 9.65 1407 325411 96325 64075589
Post transplant lymphoproliferative disorder 551.63 9.65 427 326391 9117 64162797
Epstein-Barr virus infection 525.97 9.65 465 326353 12023 64159891
Lymphoproliferative disorder 518.59 9.65 323 326495 4780 64167134
Nocardiosis 513.10 9.65 313 326505 4454 64167460
Bronchopulmonary aspergillosis 501.32 9.65 549 326269 18536 64153378
Transplant rejection 498.34 9.65 524 326294 16877 64155037
Drug abuse 478.77 9.65 55 326763 132319 64039595
Sepsis 457.64 9.65 2341 324477 228000 63943914
Diffuse large B-cell lymphoma 450.79 9.65 393 326425 9968 64161946
Haemophagocytic lymphohistiocytosis 442.61 9.65 495 326323 17114 64154800
Death 403.88 9.65 1186 325632 481519 63690395
Osteonecrosis 400.78 9.65 598 326220 27631 64144283
Polyomavirus-associated nephropathy 399.86 9.65 270 326548 4618 64167296
Hepatitis B reactivation 399.81 9.65 270 326548 4619 64167295
Strongyloidiasis 382.41 9.65 222 326596 2868 64169046
Pyrexia 371.27 9.65 4391 322427 554253 63617661
Hepatic function abnormal 366.46 9.65 925 325893 63388 64108526
Renal impairment 355.69 9.65 1491 325327 133526 64038388
Toxicity to various agents 349.48 9.65 833 325985 362680 63809234
Kidney transplant rejection 345.52 9.65 326 326492 9185 64162729
Nausea 342.13 9.65 2457 324361 783343 63388571
Posterior reversible encephalopathy syndrome 341.48 9.65 497 326321 22449 64149465
Disseminated intravascular coagulation 336.30 9.65 595 326223 31753 64140161
Aspergillus infection 331.29 9.65 412 326406 15967 64155947
Drug hypersensitivity 328.73 9.65 434 326384 237381 63934533
Injection site pain 328.56 9.65 80 326738 111328 64060586
Anxiety 322.98 9.65 330 326488 202319 63969595
Varicella zoster virus infection 318.61 9.65 215 326603 3673 64168241
Epstein-Barr virus associated lymphoproliferative disorder 315.87 9.65 197 326621 2922 64168992
Overdose 306.64 9.65 217 326601 159349 64012565
Cytomegalovirus colitis 300.06 9.65 208 326610 3720 64168194
Multiple organ dysfunction syndrome 299.00 9.65 1160 325658 100253 64071661
Progressive multifocal leukoencephalopathy 290.55 9.65 408 326410 17824 64154090
Complications of transplanted kidney 290.02 9.65 232 326586 5203 64166711
Cytomegalovirus viraemia 288.74 9.65 314 326504 10514 64161400
Thrombotic microangiopathy 288.44 9.65 388 326430 16267 64155647
Hypogammaglobulinaemia 285.76 9.65 305 326513 9994 64161920
BK virus infection 284.57 9.65 262 326556 7150 64164764
Asthenia 283.92 9.65 1161 325657 426883 63745031
Fall 279.32 9.65 1126 325692 415700 63756214
Chorioretinopathy 274.96 9.65 159 326659 2038 64169876
Abdominal discomfort 274.81 9.65 311 326507 182011 63989903
Hypotension 272.03 9.65 1003 325815 379971 63791943
Dizziness 267.32 9.65 1196 325622 428967 63742947
Osteonecrosis of jaw 264.62 9.65 608 326210 39217 64132697
Steroid diabetes 263.98 9.65 166 326652 2500 64169414
Hepatitis E 262.61 9.65 160 326658 2271 64169643
Pulmonary nocardiosis 259.40 9.65 109 326709 650 64171264
Respiratory failure 256.80 9.65 1544 325274 159639 64012275
Polyomavirus viraemia 253.71 9.65 122 326696 1040 64170874
Disease recurrence 252.68 9.65 519 326299 30991 64140923
Sinusitis 250.73 9.65 222 326596 145706 64026208
Pancytopenia 250.53 9.65 1407 325411 141902 64030012
Pulmonary tuberculosis 239.94 9.65 236 326582 7008 64164906
Leukopenia 237.49 9.65 1080 325738 100162 64071752
Headache 236.35 9.65 1642 325176 527825 63644089
Cytomegalovirus infection reactivation 233.78 9.65 210 326608 5546 64166368
Pain in extremity 230.24 9.65 777 326041 302308 63869606
Intentional overdose 229.91 9.65 84 326734 89860 64082054
Peripheral swelling 226.62 9.65 448 326370 208705 63963209
Feeling abnormal 222.67 9.65 209 326609 133393 64038521
Off label use 221.95 9.65 4464 322354 628342 63543572
General physical health deterioration 219.85 9.65 1779 325039 202646 63969268
Disseminated tuberculosis 219.22 9.65 167 326651 3478 64168436
Septic shock 215.57 9.65 1081 325737 104356 64067558
Immunosuppressant drug level increased 212.12 9.65 221 326597 7038 64164876
Weight increased 211.89 9.65 480 326338 212868 63959046
Arthropathy 211.45 9.65 181 326637 120786 64051128
Cryptococcosis 210.71 9.65 146 326672 2609 64169305
Joint swelling 208.73 9.65 491 326327 214891 63957023
Cushingoid 207.14 9.65 223 326595 7380 64164534
Pneumatosis intestinalis 203.01 9.65 186 326632 5043 64166871
Pneumonia bacterial 201.33 9.65 310 326508 14725 64157189
Drug intolerance 199.93 9.65 407 326411 187585 63984329
Depression 199.06 9.65 392 326426 182899 63989015
Mucormycosis 197.69 9.65 214 326604 7127 64164787
Nasopharyngitis 197.25 9.65 438 326380 195635 63976279
Blood pressure increased 196.18 9.65 359 326459 172193 63999721
JC virus infection 191.47 9.65 149 326669 3206 64168708
Muscle spasms 189.01 9.65 263 326555 140760 64031154
Cytomegalovirus test positive 188.15 9.65 177 326641 4967 64166947
Arthralgia 184.86 9.65 1397 325421 440863 63731051
Synovitis 183.49 9.65 140 326678 98950 64072964
Brain abscess 180.68 9.65 158 326660 4023 64167891
Cardiac failure congestive 178.54 9.65 240 326578 130340 64041574
Atypical femur fracture 178.28 9.65 165 326653 4533 64167381
Hand deformity 175.66 9.65 50 326768 62721 64109193
Blood lactate dehydrogenase increased 174.18 9.65 462 326356 32616 64139298
Liver disorder 170.18 9.65 626 326192 52725 64119189
Pneumonia cytomegaloviral 169.73 9.65 155 326663 4184 64167730
Wrong technique in product usage process 167.19 9.65 60 326758 64914 64107000
Viraemia 166.90 9.65 119 326699 2230 64169684
Febrile neutropenia 164.74 9.65 1562 325256 186095 63985819
Alveolar proteinosis 164.45 9.65 73 326745 507 64171407
Pneumomediastinum 161.62 9.65 127 326691 2773 64169141
Insomnia 159.26 9.65 494 326324 197342 63974572
Herpes zoster 159.09 9.65 808 326010 78379 64093535
COVID-19 157.28 9.65 701 326117 64439 64107475
Swelling 156.16 9.65 364 326454 159854 64012060
Blood pressure fluctuation 155.34 9.65 36 326782 51835 64120079
Acquired gene mutation 153.66 9.65 106 326712 1880 64170034
Acute respiratory distress syndrome 152.29 9.65 489 326329 38446 64133468
Confusional state 151.94 9.65 743 326075 260401 63911513
Hospitalisation 150.11 9.65 98 326720 75109 64096805
Bradycardia 150.03 9.65 229 326589 117990 64053924
Injection site erythema 148.61 9.65 87 326731 70713 64101201
Cerebrovascular accident 147.83 9.65 296 326522 137287 64034627
Neutropenic sepsis 147.69 9.65 349 326469 22923 64148991
Glossodynia 146.78 9.65 72 326746 64624 64107290
Pseudomonas infection 146.26 9.65 297 326521 17586 64154328
Cytomegalovirus chorioretinitis 146.14 9.65 151 326667 4761 64167153
Diabetes mellitus 143.27 9.65 692 326126 65782 64106132
C-reactive protein increased 140.24 9.65 892 325926 94017 64077897
Phaeohyphomycosis 137.80 9.65 79 326739 995 64170919
Infection reactivation 137.74 9.65 100 326718 1930 64169984
Herpes simplex 136.55 9.65 214 326604 10322 64161592
Disseminated cryptococcosis 136.46 9.65 90 326728 1477 64170437
Therapeutic product effect decreased 135.56 9.65 235 326583 115116 64056798
Transplant dysfunction 134.47 9.65 168 326650 6540 64165374
Pruritus 134.09 9.65 979 325839 311421 63860493
Pemphigus 134.05 9.65 70 326748 60631 64111283
Drug resistance 133.79 9.65 437 326381 34665 64137249
Escherichia infection 133.78 9.65 260 326558 14908 64157006
Adenovirus infection 133.29 9.65 174 326644 7081 64164833
Pneumocystis jirovecii infection 132.88 9.65 104 326714 2257 64169657
Bone marrow failure 132.77 9.65 538 326280 47414 64124500
Pneumonia 132.00 9.65 3739 323079 555837 63616077
Tuberculosis 130.59 9.65 236 326582 12802 64159112
Pneumonia cryptococcal 129.88 9.65 80 326738 1159 64170755
Electrocardiogram QT prolonged 129.17 9.65 127 326691 79321 64092593
Gait disturbance 126.73 9.65 447 326371 171708 64000206
Pneumothorax 126.53 9.65 338 326480 23960 64147954
Contusion 126.04 9.65 241 326577 113724 64058190
Mental status changes 125.77 9.65 77 326741 61085 64110829
Musculoskeletal stiffness 125.67 9.65 273 326545 122933 64048981
Somnolence 125.10 9.65 568 326250 203077 63968837
Scleroderma renal crisis 125.03 9.65 54 326764 348 64171566
Transplant failure 124.53 9.65 123 326695 3671 64168243
Weight decreased 124.27 9.65 892 325926 284847 63887067
Discomfort 123.91 9.65 136 326682 80742 64091172
Alopecia 123.45 9.65 428 326390 165262 64006652
Organising pneumonia 123.06 9.65 188 326630 8867 64163047
Substance-induced psychotic disorder 122.86 9.65 106 326712 2649 64169265
Unevaluable event 122.65 9.65 51 326767 50438 64121476
Balance disorder 122.22 9.65 147 326671 83779 64088135
Injection site reaction 121.93 9.65 42 326776 46622 64125292
Mycobacterial infection 121.32 9.65 109 326709 2879 64169035
Upper respiratory tract inflammation 121.16 9.65 121 326697 3661 64168253
Atypical mycobacterial infection 120.94 9.65 78 326740 1230 64170684
Migraine 119.32 9.65 86 326732 62591 64109323
Premature delivery 119.29 9.65 280 326538 18309 64153605
Diffuse large B-cell lymphoma recurrent 118.43 9.65 110 326708 3036 64168878
Nephrotic syndrome 118.04 9.65 190 326628 9377 64162537
Stress 117.95 9.65 81 326737 60453 64111461
Graft versus host disease 117.25 9.65 233 326585 13580 64158334
Lymphopenia 116.94 9.65 340 326478 25317 64146597
Heart rate increased 116.87 9.65 200 326618 98475 64073439
Adult T-cell lymphoma/leukaemia 116.24 9.65 48 326770 272 64171642
Sedation 116.05 9.65 33 326785 41429 64130485
Chronic graft versus host disease 116.05 9.65 151 326667 6125 64165789
Cytomegalovirus enterocolitis 116.00 9.65 77 326741 1278 64170636
Immunosuppression 115.99 9.65 201 326617 10545 64161369
Back pain 115.66 9.65 767 326051 249404 63922510
Nephropathy toxic 114.79 9.65 266 326552 17248 64154666
Intentional product misuse 114.74 9.65 118 326700 72177 64099737
Nasal congestion 114.69 9.65 81 326737 59577 64112337
Heart rate decreased 113.69 9.65 69 326749 54998 64116916
Epstein Barr virus positive mucocutaneous ulcer 113.49 9.65 60 326758 637 64171277
Liver transplant rejection 113.17 9.65 105 326713 2894 64169020
Anti-cyclic citrullinated peptide antibody positive 112.67 9.65 55 326763 49507 64122407
Suicide attempt 112.58 9.65 116 326702 70891 64101023
Hypersensitivity 111.87 9.65 563 326255 195889 63976025
Hepatic failure 111.08 9.65 565 326253 54829 64117085
Meningitis cryptococcal 110.94 9.65 104 326714 2905 64169009
Angiocentric lymphoma 107.95 9.65 61 326757 746 64171168
Memory impairment 107.71 9.65 167 326651 85515 64086399
Lymphocytic infiltration 106.43 9.65 74 326744 1330 64170584
Blood pressure systolic increased 106.31 9.65 59 326759 49394 64122520
Peritonitis 105.89 9.65 323 326495 24700 64147214
Neutropenia 105.80 9.65 1754 325064 237870 63934044
Injection site bruising 105.48 9.65 27 326791 36346 64135568
Mycobacterium abscessus infection 105.10 9.65 65 326753 949 64170965
Contraindicated product administered 105.01 9.65 245 326573 107584 64064330
Gamma-glutamyltransferase increased 104.52 9.65 505 326313 48005 64123909
Enterococcal infection 103.70 9.65 222 326596 13644 64158270
Agranulocytosis 103.52 9.65 426 326392 37803 64134111
Lymphoma 102.88 9.65 222 326596 13719 64158195
Parvovirus B19 infection 102.68 9.65 69 326749 1170 64170744
Central nervous system lymphoma 101.97 9.65 82 326736 1853 64170061
Lupus nephritis 101.54 9.65 90 326728 2334 64169580
Irritable bowel syndrome 100.50 9.65 32 326786 37337 64134577
Proteinuria 100.19 9.65 339 326479 27384 64144530
Osteoporosis 100.17 9.65 451 326367 41629 64130285
Inappropriate schedule of product administration 99.57 9.65 198 326620 92088 64079826
Neuroleptic malignant syndrome 99.41 9.65 7 326811 24989 64146925
Myopathy 99.29 9.65 253 326565 17427 64154487
Constipation 98.66 9.65 718 326100 228619 63943295
Myocardial infarction 98.56 9.65 468 326350 165353 64006561
Arthritis bacterial 98.52 9.65 157 326661 7682 64164232
Immunosuppressant drug level decreased 97.96 9.65 78 326740 1737 64170177
Injection site swelling 96.91 9.65 44 326774 41309 64130605
Therapy cessation 96.39 9.65 23 326795 32466 64139448
Lung abscess 96.10 9.65 104 326714 3462 64168452
Sleep disorder due to general medical condition, insomnia type 94.71 9.65 11 326807 26259 64145655
Oesophageal candidiasis 94.55 9.65 156 326662 7861 64164053
Epstein-Barr virus infection reactivation 94.40 9.65 64 326754 1102 64170812
Tendon rupture 94.27 9.65 184 326634 10583 64161331
Serotonin syndrome 93.30 9.65 41 326777 39241 64132673
Pleurisy 92.82 9.65 168 326650 9123 64162791
Hyperglycaemia 91.26 9.65 575 326243 60393 64111521
Encephalitis 90.28 9.65 198 326620 12373 64159541
Chronic allograft nephropathy 89.96 9.65 69 326749 1452 64170462
Platelet count decreased 89.92 9.65 1269 325549 166442 64005472
Cytomegalovirus enteritis 89.32 9.65 51 326767 637 64171277
Injection site pruritus 89.03 9.65 40 326778 37786 64134128
Vasculitis 88.51 9.65 246 326572 17849 64154065
Staphylococcal sepsis 87.95 9.65 199 326619 12700 64159214
Trichophytosis 87.64 9.65 40 326778 299 64171615
Rebound effect 85.82 9.65 115 326703 4802 64167112
Myelodysplastic syndrome 85.75 9.65 321 326497 27258 64144656
Cardio-respiratory arrest 85.42 9.65 237 326581 98156 64073758
Visceral leishmaniasis 85.33 9.65 56 326762 911 64171003
Kaposi's sarcoma 85.30 9.65 51 326767 698 64171216
Cerebral infarction 84.65 9.65 422 326396 40622 64131292
Psoriasis 84.29 9.65 146 326672 71557 64100357
Muscle abscess 84.09 9.65 54 326764 845 64171069
Mycobacterium chelonae infection 82.93 9.65 76 326742 2061 64169853
Device issue 82.87 9.65 9 326809 22639 64149275
Obliterative bronchiolitis 81.23 9.65 83 326735 2582 64169332
Symptom masked 80.98 9.65 59 326759 1145 64170769
Listeria sepsis 80.54 9.65 46 326772 575 64171339
Spinal compression fracture 80.46 9.65 209 326609 14566 64157348
Product quality issue 79.28 9.65 26 326792 29773 64142141
Dehydration 79.25 9.65 709 326109 216054 63955860
Renal transplant failure 79.08 9.65 66 326752 1574 64170340
Hypoalbuminaemia 78.42 9.65 232 326586 17442 64154472
Hyperhidrosis 78.12 9.65 346 326472 124574 64047340
Oral candidiasis 77.93 9.65 277 326541 22935 64148979
Tubulointerstitial nephritis 77.90 9.65 337 326481 30572 64141342
Lung infiltration 77.75 9.65 258 326560 20631 64151283
Systemic mycosis 77.53 9.65 76 326742 2247 64169667
Full blood count abnormal 77.36 9.65 27 326791 29730 64142184
Dermoid cyst 76.98 9.65 35 326783 259 64171655
Ill-defined disorder 76.83 9.65 66 326752 43986 64127928
Poisoning 76.82 9.65 10 326808 21869 64150045
Intentional self-injury 76.12 9.65 26 326792 29018 64142896
Respiratory arrest 74.83 9.65 95 326723 52890 64119024
Rheumatoid factor positive 74.64 9.65 42 326776 34896 64137018
Diarrhoea 74.32 9.65 2953 323865 719751 63452163
Muscle injury 74.06 9.65 21 326797 26416 64145498
Incorrect dose administered 73.94 9.65 121 326697 60644 64111270
Accidental exposure to product 73.75 9.65 21 326797 26343 64145571
Unresponsive to stimuli 73.64 9.65 88 326730 50305 64121609
Blood beta-D-glucan increased 73.59 9.65 41 326777 487 64171427
Renal phospholipidosis 73.56 9.65 26 326792 88 64171826
Osteoporotic fracture 73.54 9.65 91 326727 3507 64168407
Klebsiella infection 73.49 9.65 189 326629 13092 64158822
Full blood count decreased 73.17 9.65 13 326805 22569 64149345
Gastrooesophageal reflux disease 73.11 9.65 199 326619 82944 64088970
Large intestine perforation 72.48 9.65 182 326636 12422 64159492
Suicidal ideation 72.43 9.65 142 326676 66400 64105514
Subcutaneous abscess 72.34 9.65 129 326689 6924 64164990
Therapy partial responder 72.00 9.65 160 326658 10088 64161826
Subcutaneous emphysema 71.94 9.65 62 326756 1547 64170367
Adrenal insufficiency 70.97 9.65 263 326555 22224 64149690
Bronchiectasis 70.91 9.65 194 326624 13946 64157968
Neck pain 70.78 9.65 127 326691 61406 64110508
Steroid withdrawal syndrome 70.77 9.65 43 326775 607 64171307
Enterocolitis 70.65 9.65 175 326643 11843 64160071
Injection site haemorrhage 70.44 9.65 18 326800 24260 64147654
Toxic epidermal necrolysis 70.29 9.65 373 326445 36793 64135121
Burning sensation 70.18 9.65 89 326729 49575 64122339
Alanine aminotransferase increased 70.14 9.65 1041 325777 137990 64033924
Drug ineffective for unapproved indication 69.89 9.65 328 326490 30805 64141109
Rhinorrhoea 69.67 9.65 123 326695 59846 64112068
Bacterial sepsis 69.67 9.65 131 326687 7326 64164588
Emotional distress 69.17 9.65 49 326769 35989 64135925
Pleural effusion 69.17 9.65 961 325857 125598 64046316
Multiple sclerosis relapse 68.90 9.65 64 326754 41071 64130843
Endocarditis bacterial 68.84 9.65 56 326762 1287 64170627
Heart transplant rejection 68.80 9.65 55 326763 1232 64170682
Infection in an immunocompromised host 67.90 9.65 50 326768 987 64170927
Adrenal suppression 67.32 9.65 55 326763 1272 64170642
Cystitis haemorrhagic 67.28 9.65 134 326684 7822 64164092
Wound 67.28 9.65 183 326635 76294 64095620
Opportunistic infection 67.17 9.65 75 326743 2587 64169327
Fungal endocarditis 67.16 9.65 38 326780 466 64171448
Retinal detachment 67.05 9.65 134 326684 7842 64164072
Pyelonephritis 66.73 9.65 216 326602 17050 64154864
Acute graft versus host disease in skin 66.01 9.65 122 326696 6733 64165181
Blood glucose increased 65.41 9.65 265 326553 97808 64074106
Nervousness 65.37 9.65 34 326784 29522 64142392
Intestinal perforation 65.10 9.65 198 326620 15115 64156799
Cytogenetic abnormality 64.95 9.65 49 326769 1005 64170909
Injury 64.91 9.65 115 326703 55877 64116037
Angiosarcoma 64.90 9.65 35 326783 388 64171526
Necrotising retinitis 64.58 9.65 49 326769 1014 64170900
Infusion related reaction 64.54 9.65 528 326290 163939 64007975
Acinetobacter infection 63.99 9.65 70 326748 2359 64169555
Hypoaesthesia 63.96 9.65 427 326391 138681 64033233
Small intestinal perforation 63.92 9.65 72 326746 2508 64169406
Exposure during pregnancy 63.86 9.65 638 326180 77037 64094877
Amnesia 63.65 9.65 91 326727 48178 64123736
Actinic keratosis 62.93 9.65 102 326716 5063 64166851
Tremor 62.77 9.65 466 326352 147764 64024150
Infectious pleural effusion 62.75 9.65 75 326743 2787 64169127
Squamous cell carcinoma of skin 62.64 9.65 166 326652 11710 64160204
Mycobacterium avium complex infection 62.51 9.65 88 326730 3852 64168062
Fluid retention 62.48 9.65 130 326688 59476 64112438
Oxygen saturation decreased 62.19 9.65 305 326513 106871 64065043
Dyspepsia 62.13 9.65 204 326614 80108 64091806
Loss of consciousness 62.08 9.65 468 326350 147897 64024017
Agitation 61.98 9.65 234 326584 88133 64083781
Influenza like illness 61.83 9.65 138 326680 61564 64110350
Therapy interrupted 61.82 9.65 13 326805 20023 64151891
Aplasia pure red cell 61.57 9.65 120 326698 6894 64165020
Staphylococcal infection 61.56 9.65 454 326364 50224 64121690
Growth retardation 61.52 9.65 56 326762 1505 64170409
Sweat gland tumour 61.48 9.65 36 326782 473 64171441
Meningitis listeria 61.31 9.65 42 326776 736 64171178
Chest pain 61.10 9.65 835 325983 235145 63936769
Focal segmental glomerulosclerosis 61.05 9.65 75 326743 2869 64169045
Lymphocele 61.04 9.65 57 326761 1584 64170330
Red blood cell sedimentation rate abnormal 60.90 9.65 6 326812 16300 64155614
Acute graft versus host disease 60.67 9.65 139 326679 8945 64162969
Tumour lysis syndrome 60.21 9.65 226 326592 19214 64152700
B-cell lymphoma 60.11 9.65 103 326715 5354 64166560
Endocarditis 59.89 9.65 141 326677 9237 64162677
Paraesthesia 59.82 9.65 417 326401 134105 64037809
Loss of personal independence in daily activities 59.60 9.65 179 326639 72275 64099639
Basal cell carcinoma 59.35 9.65 311 326507 30527 64141387
Meningitis bacterial 59.10 9.65 66 326752 2277 64169637
Bacterial infection 59.07 9.65 267 326551 24683 64147231
Intraocular pressure increased 58.76 9.65 130 326688 8172 64163742
Malignant neoplasm of conjunctiva 58.30 9.65 18 326800 34 64171880
Injection site mass 58.05 9.65 9 326809 17261 64154653
Cardiac arrest 58.01 9.65 500 326318 153564 64018350
Cerebral toxoplasmosis 57.72 9.65 58 326760 1768 64170146
Coma 57.64 9.65 238 326580 87377 64084537
Pyoderma gangrenosum 57.62 9.65 75 326743 3043 64168871
Peripheral T-cell lymphoma unspecified 57.56 9.65 37 326781 580 64171334
Gastroenteritis 57.43 9.65 300 326518 29411 64142503
Candida infection 57.16 9.65 312 326506 31107 64140807
Drug withdrawal syndrome 56.90 9.65 45 326773 31246 64140668
Epstein-Barr viraemia 56.66 9.65 57 326761 1740 64170174
Cardiac disorder 56.62 9.65 124 326694 55692 64116222
Myelosuppression 56.40 9.65 255 326563 23575 64148339
Retinal drusen 56.21 9.65 16 326802 19 64171895
Human herpesvirus 8 infection 55.54 9.65 45 326773 1028 64170886
Drug eruption 55.44 9.65 343 326475 35793 64136121
Systemic candida 55.34 9.65 98 326720 5231 64166683
Ocular hypertension 55.19 9.65 48 326770 1213 64170701
Coronary artery disease 55.14 9.65 142 326676 60291 64111623
Varicella zoster pneumonia 54.86 9.65 21 326797 94 64171820
Gallbladder rupture 54.57 9.65 40 326778 784 64171130
Listeriosis 54.05 9.65 58 326760 1912 64170002
Anhedonia 54.04 9.65 4 326814 13702 64158212
Flushing 54.04 9.65 210 326608 78438 64093476
Pneumonia fungal 54.03 9.65 131 326687 8746 64163168
Pneumonitis 53.85 9.65 438 326380 49927 64121987
C-reactive protein abnormal 53.80 9.65 41 326777 29006 64142908
Hypofibrinogenaemia 53.51 9.65 55 326763 1723 64170191
Vomiting 53.31 9.65 2267 324551 548850 63623064
Human polyomavirus infection 53.31 9.65 43 326775 976 64170938
Dry skin 53.27 9.65 112 326706 51049 64120865
Pneumoperitoneum 52.91 9.65 67 326751 2644 64169270
Head injury 52.79 9.65 53 326765 32789 64139125
Epistaxis 52.57 9.65 287 326531 97844 64074070
Pericarditis 52.47 9.65 153 326665 62363 64109551
Lung consolidation 52.13 9.65 119 326699 7639 64164275
Blood glucose decreased 52.04 9.65 26 326792 23097 64148817
Hepatic enzyme increased 51.96 9.65 415 326403 129528 64042386
Thrombocytopenia 51.82 9.65 1493 325325 222308 63949606
Mycetoma mycotic 51.81 9.65 20 326798 92 64171822
Alternaria infection 51.76 9.65 34 326784 554 64171360
Graft loss 51.64 9.65 42 326776 965 64170949
Cutaneous nocardiosis 51.54 9.65 23 326795 162 64171752
International normalised ratio increased 51.48 9.65 216 326602 78951 64092963
Scedosporium infection 51.42 9.65 46 326772 1208 64170706
Seizure 51.32 9.65 569 326249 166323 64005591
Joint stiffness 51.28 9.65 47 326771 30357 64141557
Eosinophilic granulomatosis with polyangiitis 51.21 9.65 68 326750 2814 64169100
Mobility decreased 51.13 9.65 242 326576 85598 64086316
Cutaneous tuberculosis 51.10 9.65 24 326794 193 64171721
Orthostatic hypotension 50.64 9.65 100 326718 46638 64125276
Cytomegalovirus oesophagitis 50.62 9.65 34 326784 576 64171338
Hepatosplenomegaly 50.09 9.65 94 326724 5249 64166665
Mycobacterium marinum infection 49.99 9.65 29 326789 374 64171540
Varicella 49.93 9.65 64 326754 2557 64169357
Intestinal tuberculosis 49.78 9.65 22 326796 151 64171763
Sinus congestion 49.78 9.65 9 326809 15430 64156484
Viral vasculitis 49.32 9.65 21 326797 130 64171784
Tuberculous pleurisy 49.29 9.65 33 326785 556 64171358
Enterococcal sepsis 49.25 9.65 62 326756 2432 64169482
Haemolytic anaemia 49.20 9.65 186 326632 15867 64156047
Immune reconstitution inflammatory syndrome 49.10 9.65 157 326661 12313 64159601
Gastrointestinal perforation 49.08 9.65 94 326724 5330 64166584
Rheumatoid arthritis 49.00 9.65 564 326254 163730 64008184
Blood pressure diastolic decreased 48.81 9.65 26 326792 22275 64149639
Gastroenteritis norovirus 48.58 9.65 65 326753 2710 64169204
Delayed graft function 48.45 9.65 68 326750 2968 64168946
Amoebic colitis 48.42 9.65 18 326800 73 64171841
Cytomegalovirus gastroenteritis 48.31 9.65 29 326789 400 64171514
Erythema multiforme 48.18 9.65 182 326636 15519 64156395
Epstein-Barr virus associated lymphoma 48.03 9.65 39 326779 894 64171020
Keratitis 47.98 9.65 70 326748 3167 64168747
Throat irritation 47.92 9.65 57 326761 32654 64139260
Necrotising fasciitis 47.83 9.65 92 326726 5234 64166680
Diffuse large B-cell lymphoma refractory 47.61 9.65 42 326776 1082 64170832
Lactic acidosis 47.49 9.65 156 326662 61254 64110660
Device dislocation 47.38 9.65 24 326794 21154 64150760
Lymphadenopathy 47.23 9.65 401 326417 46285 64125629
Dermatophytosis 47.16 9.65 28 326790 378 64171536
Lemierre syndrome 47.16 9.65 19 326799 100 64171814
Gestational diabetes 47.09 9.65 94 326724 5496 64166418
Skin ulcer 46.78 9.65 382 326436 43592 64128322
Urticaria 46.59 9.65 499 326319 146818 64025096
Inflammatory marker increased 46.49 9.65 120 326698 8331 64163583
Cytomegalovirus gastritis 46.22 9.65 28 326790 393 64171521
Cytomegalovirus hepatitis 46.03 9.65 32 326786 575 64171339
Heart rate irregular 45.50 9.65 43 326775 27370 64144544
Ileal ulcer 45.39 9.65 39 326779 969 64170945
Polyomavirus test positive 45.21 9.65 22 326796 193 64171721
Bone tuberculosis 45.20 9.65 29 326789 453 64171461
Lymph node tuberculosis 45.12 9.65 38 326780 918 64170996
Body temperature decreased 45.03 9.65 39 326779 25889 64146025
Aspartate aminotransferase increased 45.01 9.65 855 325963 118933 64052981
Liver abscess 44.73 9.65 89 326729 5191 64166723
Viral load increased 44.68 9.65 59 326759 2428 64169486
Hypersomnia 44.63 9.65 22 326796 19695 64152219
Graft versus host disease in gastrointestinal tract 44.46 9.65 92 326726 5520 64166394
Pyelonephritis acute 44.05 9.65 87 326731 5047 64166867
Infective aneurysm 43.72 9.65 36 326782 842 64171072
Epstein-Barr virus test positive 43.70 9.65 38 326780 960 64170954
Osteoarthritis 43.58 9.65 169 326649 63167 64108747
Hot flush 43.45 9.65 107 326711 46128 64125786
Large intestinal ulcer 43.40 9.65 77 326741 4116 64167798
Ear infection 43.39 9.65 33 326785 23371 64148543
Pulmonary alveolar haemorrhage 43.37 9.65 128 326690 9610 64162304
Urosepsis 43.33 9.65 224 326594 21870 64150044
B-cell lymphoma recurrent 43.30 9.65 35 326783 797 64171117
Poisoning deliberate 43.06 9.65 8 326810 13450 64158464
Psoas abscess 42.84 9.65 36 326782 867 64171047
Glomerulonephritis membranoproliferative 42.74 9.65 29 326789 500 64171414
Fibromyalgia 42.68 9.65 72 326746 35659 64136255
Disseminated varicella zoster virus infection 42.65 9.65 23 326795 255 64171659
Splenic abscess 42.64 9.65 28 326790 456 64171458
Endophthalmitis 42.56 9.65 88 326730 5277 64166637
Underdose 42.30 9.65 41 326777 25788 64146126
Pseudomembranous colitis 41.81 9.65 83 326735 4833 64167081
Prostatic specific antigen increased 41.77 9.65 118 326700 8642 64163272
Oropharyngeal pain 41.73 9.65 271 326547 88596 64083318
Placenta accreta 41.54 9.65 20 326798 171 64171743
Empyema 41.46 9.65 70 326748 3595 64168319
Peripheral T-cell lymphoma unspecified stage IV 41.30 9.65 13 326805 27 64171887
Adenoviral haemorrhagic cystitis 41.25 9.65 28 326790 483 64171431
Haemorrhage subcutaneous 41.23 9.65 77 326741 4284 64167630
Infective spondylitis 41.20 9.65 26 326792 394 64171520
Dyskinesia 41.20 9.65 86 326732 39302 64132612
Cognitive disorder 41.19 9.65 142 326676 54945 64116969
Sinus disorder 41.19 9.65 17 326801 16891 64155023
Trichosporon infection 41.16 9.65 35 326783 857 64171057
Chest discomfort 40.99 9.65 383 326435 115723 64056191
Peliosis hepatis 40.71 9.65 16 326802 78 64171836
Haemolytic uraemic syndrome 40.54 9.65 73 326745 3948 64167966
Blood pressure diastolic abnormal 40.54 9.65 6 326812 11911 64160003
Meningitis 40.50 9.65 113 326705 8216 64163698
Graft versus host disease in skin 40.43 9.65 86 326732 5261 64166653
Bacteraemia 40.38 9.65 254 326564 26657 64145257
Oesophageal perforation 40.35 9.65 37 326781 1004 64170910
Ecthyma 40.32 9.65 30 326788 602 64171312
Musculoskeletal chest pain 40.19 9.65 30 326788 21449 64150465
Human herpesvirus 6 infection 40.10 9.65 79 326739 4575 64167339
Gallbladder disorder 40.09 9.65 18 326800 17012 64154902
Stem cell transplant 40.06 9.65 67 326751 3414 64168500
Cerebral aspergillosis 39.83 9.65 46 326772 1647 64170267
Concomitant disease aggravated 39.83 9.65 139 326679 11403 64160511
Adverse drug reaction 39.82 9.65 109 326709 45355 64126559
Injection site rash 39.71 9.65 15 326803 15727 64156187
Keratitis bacterial 39.50 9.65 18 326800 134 64171780
Feeling jittery 39.49 9.65 4 326814 10631 64161283
Systemic lupus erythematosus 39.40 9.65 231 326587 77381 64094533
Thymoma 39.38 9.65 18 326800 135 64171779
Hypoglycaemia 39.29 9.65 280 326538 89612 64082302
Acute abdomen 38.89 9.65 59 326759 2765 64169149
Pulmonary cavitation 38.88 9.65 41 326777 1324 64170590
Autoimmune neutropenia 38.83 9.65 25 326793 393 64171521
Maternal exposure during pregnancy 38.67 9.65 692 326126 95192 64076722
Immune thrombocytopenia 38.53 9.65 165 326653 14901 64157013
Plasma cell myeloma 38.49 9.65 113 326705 45962 64125952
Respiratory tract congestion 38.19 9.65 17 326801 16148 64155766
Herpes zoster meningoencephalitis 37.98 9.65 30 326788 660 64171254
Syncope 37.87 9.65 566 326252 157069 64014845
Abdominal pain upper 37.85 9.65 641 326177 174389 63997525
T-cell lymphoma 37.82 9.65 38 326780 1158 64170756
Anogenital warts 37.76 9.65 32 326786 780 64171134
Glomerulonephritis membranous 37.73 9.65 40 326778 1300 64170614
Sneezing 37.69 9.65 15 326803 15236 64156678
Human T-cell lymphotropic virus type I infection 37.54 9.65 15 326803 77 64171837
Parvovirus infection 37.46 9.65 28 326790 566 64171348
Intensive care unit acquired weakness 37.44 9.65 45 326773 1682 64170232
Pouchitis 37.35 9.65 32 326786 792 64171122
Limb discomfort 37.06 9.65 50 326768 27125 64144789
Psoriatic arthropathy 36.99 9.65 105 326713 43176 64128738
Visual acuity reduced 36.96 9.65 250 326568 26891 64145023
Systemic infection 36.81 9.65 73 326745 4248 64167666
Microsporidia infection 36.63 9.65 31 326787 754 64171160
Limb injury 36.57 9.65 39 326779 23466 64148448
Lumbar vertebral fracture 36.53 9.65 84 326734 5418 64166496
Aortic dissection 36.51 9.65 64 326754 3388 64168526
Leukoencephalopathy 36.35 9.65 97 326721 6870 64165044
Squamous cell carcinoma 36.32 9.65 153 326665 13716 64158198
Blood pressure systolic abnormal 36.25 9.65 4 326814 9938 64161976
Lung transplant rejection 36.16 9.65 39 326779 1293 64170621
Cytomegalovirus gastrointestinal ulcer 36.13 9.65 13 326805 47 64171867
Aggression 36.05 9.65 117 326701 46115 64125799
Hydrocephalus 35.95 9.65 102 326716 7489 64164425
Corneal lesion 35.92 9.65 13 326805 48 64171866
Human herpesvirus 6 infection reactivation 35.86 9.65 21 326797 276 64171638
Gastrointestinal disorder 35.63 9.65 287 326531 89422 64082492
Hernia 35.60 9.65 12 326806 13506 64158408
Dry mouth 35.58 9.65 171 326647 60247 64111667
Trichophytic granuloma 35.51 9.65 13 326805 50 64171864
Jaw operation 35.47 9.65 30 326788 729 64171185
Normal newborn 35.38 9.65 84 326734 5533 64166381
Purpura 35.33 9.65 177 326641 17069 64154845
Sleep disorder 35.16 9.65 169 326649 59540 64112374
Pneumonia acinetobacter 34.90 9.65 16 326802 121 64171793
Myelopathy 34.89 9.65 68 326750 3906 64168008
Skin erosion 34.86 9.65 67 326751 3809 64168105
Infective tenosynovitis 34.84 9.65 21 326797 292 64171622
Dysgeusia 34.68 9.65 122 326696 46925 64124989
Retinal haemorrhage 34.64 9.65 99 326719 7299 64164615
Meningitis tuberculous 34.59 9.65 35 326783 1076 64170838
Illness 34.58 9.65 36 326782 21902 64150012
Restless legs syndrome 34.56 9.65 22 326796 17094 64154820
Lymphoplasmacytoid lymphoma/immunocytoma 34.55 9.65 12 326806 38 64171876
Cytomegalovirus gastrointestinal infection 34.49 9.65 24 326794 432 64171482
Cardiac valve vegetation 34.40 9.65 31 326787 822 64171092
Oesophageal carcinoma 34.39 9.65 75 326743 4668 64167246
Pneumonia pneumococcal 34.26 9.65 60 326758 3174 64168740
Pancreatitis acute 34.25 9.65 350 326468 42505 64129409
Fear 34.23 9.65 31 326787 20140 64151774
Skin mass 34.15 9.65 96 326722 7010 64164904
Ileus paralytic 34.09 9.65 107 326711 8308 64163606
Condition aggravated 33.94 9.65 2255 324563 370171 63801743
Feeling hot 33.94 9.65 118 326700 45545 64126369
Steroid dependence 33.92 9.65 23 326795 396 64171518
Colitis 33.86 9.65 450 326368 58224 64113690
Dengue fever 33.84 9.65 30 326788 778 64171136
Infertility 33.80 9.65 25 326793 497 64171417
IgA nephropathy 33.80 9.65 39 326779 1395 64170519
Glomerulonephritis proliferative 33.78 9.65 22 326796 353 64171561
Injection site warmth 33.67 9.65 13 326805 13449 64158465
Gastric cancer 33.48 9.65 90 326728 6403 64165511
Gastric ulcer 33.44 9.65 265 326553 29969 64141945
Pneumococcal infection 33.43 9.65 30 326788 791 64171123
Osteomyelitis 33.42 9.65 247 326571 27340 64144574
Gastroenteritis sapovirus 33.31 9.65 16 326802 136 64171778
Cytopenia 33.27 9.65 161 326657 15310 64156604
Enteritis infectious 33.15 9.65 57 326761 2971 64168943
Sleep apnoea syndrome 33.03 9.65 63 326755 29769 64142145
Altered state of consciousness 32.94 9.65 315 326503 37587 64134327
COVID-19 pneumonia 32.84 9.65 168 326650 16336 64155578
Hypocomplementaemia 32.77 9.65 17 326801 173 64171741
Acute myeloid leukaemia 32.76 9.65 245 326573 27218 64144696
Jaundice 32.69 9.65 383 326435 48129 64123785
Hypervolaemia 32.63 9.65 93 326725 38192 64133722
Rhabdomyolysis 32.62 9.65 302 326516 91424 64080490
Hepatitis 32.57 9.65 364 326454 45218 64126696
Cardiac failure 32.54 9.65 890 325928 131483 64040431
Nephrolithiasis 32.39 9.65 113 326705 43570 64128344
Cutaneous T-cell lymphoma 32.20 9.65 49 326769 2303 64169611
Pneumothorax spontaneous 32.13 9.65 33 326785 1033 64170881
Escherichia bacteraemia 32.10 9.65 79 326739 5324 64166590
Extrapyramidal disorder 32.06 9.65 31 326787 19521 64152393
Nocardia sepsis 32.02 9.65 10 326808 20 64171894
Ascites 31.93 9.65 466 326352 61535 64110379
Premature labour 31.90 9.65 98 326720 7522 64164392
Adrenal atrophy 31.84 9.65 12 326806 51 64171863
Mediastinitis 31.84 9.65 29 326789 780 64171134
Hydronephrosis 31.83 9.65 149 326669 13976 64157938
Blood alkaline phosphatase increased 31.80 9.65 430 326388 55849 64116065
Pathogen resistance 31.79 9.65 137 326681 12406 64159508
Central nervous system vasculitis 31.70 9.65 34 326784 1120 64170794
Infusion site pain 31.56 9.65 7 326811 10390 64161524
Myasthenia gravis crisis 31.53 9.65 30 326788 854 64171060
Post herpetic neuralgia 31.52 9.65 48 326770 2257 64169657
Joint injury 31.51 9.65 42 326776 22905 64149009
Sedation complication 31.37 9.65 7 326811 10347 64161567
Tonsillitis 31.35 9.65 82 326736 5738 64166176
Encapsulating peritoneal sclerosis 31.35 9.65 29 326789 796 64171118
Cytomegalovirus duodenitis 31.29 9.65 13 326805 75 64171839
Arterial haemorrhage 31.28 9.65 47 326771 2184 64169730
Injection site urticaria 31.10 9.65 9 326809 11172 64160742
Respiratory depression 31.10 9.65 44 326774 23399 64148515
T-cell lymphoma stage IV 30.88 9.65 15 326803 131 64171783
Knee arthroplasty 30.80 9.65 56 326762 26943 64144971
Histoplasmosis disseminated 30.77 9.65 44 326774 1954 64169960
Intussusception 30.71 9.65 30 326788 883 64171031
Akathisia 30.69 9.65 10 326808 11500 64160414
Crying 30.52 9.65 34 326784 20056 64151858
Abdominal tenderness 30.52 9.65 111 326707 9294 64162620
Histoplasmosis 30.37 9.65 44 326774 1978 64169936
Adrenocortical insufficiency acute 30.36 9.65 50 326768 2515 64169399
Bronchopleural fistula 30.35 9.65 25 326793 585 64171329
Torsade de pointes 30.29 9.65 26 326792 17337 64154577
Haematocrit decreased 30.29 9.65 158 326660 54497 64117417
Bulbar palsy 30.25 9.65 18 326800 244 64171670
Wound infection pseudomonas 30.10 9.65 38 326780 1495 64170419
Presyncope 30.08 9.65 85 326733 35004 64136910
Blood calcium decreased 30.05 9.65 52 326766 25502 64146412
Device malfunction 30.04 9.65 27 326791 17606 64154308
Cardiac myxoma 29.97 9.65 14 326804 111 64171803
Colon cancer 29.91 9.65 136 326682 12603 64159311
Escherichia sepsis 29.85 9.65 92 326726 7073 64164841
Miosis 29.73 9.65 15 326803 13251 64158663
Influenza 29.72 9.65 371 326447 106160 64065754
Interleukin-2 receptor increased 29.70 9.65 16 326802 177 64171737
Neuropathy peripheral 29.61 9.65 418 326400 117107 64054807
Neuropsychiatric lupus 29.49 9.65 15 326803 146 64171768
Foetal growth restriction 29.49 9.65 40 326778 1690 64170224
Fungal skin infection 29.46 9.65 74 326744 5051 64166863
Abscess 29.46 9.65 183 326635 19121 64152793
Thrombosis 29.45 9.65 223 326595 70419 64101495
Adverse event 29.38 9.65 102 326716 39387 64132527
Myositis 29.36 9.65 162 326656 16215 64155699
Extranodal marginal zone B-cell lymphoma (MALT type) 29.35 9.65 23 326795 500 64171414
Lower respiratory tract infection 29.18 9.65 656 326162 93958 64077956
Nephritis 29.15 9.65 60 326758 3586 64168328
Intervertebral disc degeneration 29.15 9.65 15 326803 13105 64158809
Gingival hypertrophy 29.15 9.65 51 326767 2696 64169218
Rash 29.06 9.65 1967 324851 456582 63715332
Muscle spasticity 29.03 9.65 25 326793 16644 64155270
Skin striae 28.96 9.65 36 326782 1394 64170520
Cholangitis 28.94 9.65 120 326698 10682 64161232
Acute hepatitis B 28.94 9.65 21 326797 405 64171509
Meningoencephalitis herpetic 28.93 9.65 40 326778 1721 64170193
Anaphylactoid reaction 28.92 9.65 70 326748 4668 64167246
Herpes simplex test positive 28.69 9.65 20 326798 361 64171553
Exposed bone in jaw 28.61 9.65 58 326760 3429 64168485
Eye infection toxoplasmal 28.60 9.65 22 326796 465 64171449
Procedural pain 28.58 9.65 22 326796 15486 64156428
Gait inability 28.54 9.65 114 326704 42254 64129660
Mycoplasma infection 28.31 9.65 25 326793 645 64171269
Calciphylaxis 28.27 9.65 56 326762 3256 64168658
Pancreatic steatosis 28.22 9.65 30 326788 978 64170936
Pelvic deformity 28.22 9.65 12 326806 74 64171840
Middle insomnia 28.20 9.65 15 326803 12862 64159052
Chronic inflammatory demyelinating polyradiculoneuropathy 28.18 9.65 29 326789 910 64171004
Labelled drug-drug interaction medication error 28.14 9.65 200 326618 21862 64150052
Cerebral venous thrombosis 28.12 9.65 47 326771 2394 64169520
Toxoplasmosis 28.07 9.65 47 326771 2397 64169517
Malacoplakia gastrointestinal 28.07 9.65 15 326803 163 64171751
Abdominal distension 28.03 9.65 331 326487 95663 64076251
Hospice care 27.97 9.65 3 326815 7622 64164292
Pustular psoriasis 27.92 9.65 64 326754 4119 64167795
Primary biliary cholangitis 27.90 9.65 30 326788 991 64170923
White blood cell count increased 27.89 9.65 480 326338 65534 64106380
Pulmonary fibrosis 27.82 9.65 252 326566 29626 64142288
Lung adenocarcinoma 27.79 9.65 87 326731 6746 64165168
Autoimmune haemolytic anaemia 27.78 9.65 89 326729 6987 64164927
Eye abscess 27.68 9.65 18 326800 288 64171626
Retching 27.66 9.65 22 326796 15234 64156680
Hip fracture 27.65 9.65 60 326758 27039 64144875
Diverticular perforation 27.63 9.65 73 326745 5140 64166774
Pleocytosis 27.61 9.65 31 326787 1076 64170838
Chronic myeloid leukaemia 27.54 9.65 56 326762 3318 64168596
Streptococcal infection 27.50 9.65 92 326726 7387 64164527
Road traffic accident 27.46 9.65 73 326745 30672 64141242
Neisseria infection 27.44 9.65 11 326807 57 64171857
Leiomyosarcoma 27.44 9.65 17 326801 249 64171665
Central nervous system infection 27.35 9.65 32 326786 1162 64170752
Type 1 diabetes mellitus 27.35 9.65 77 326741 5628 64166286
Complications of transplanted lung 27.28 9.65 20 326798 392 64171522
Splenomegaly 27.24 9.65 170 326648 17791 64154123
Renal graft infection 27.24 9.65 20 326798 393 64171521
Meningoencephalitis bacterial 27.23 9.65 15 326803 174 64171740
Complications of transplanted liver 27.21 9.65 19 326799 344 64171570
Uveitis 27.15 9.65 132 326686 12576 64159338
Microangiopathic haemolytic anaemia 27.12 9.65 34 326784 1328 64170586
Disseminated varicella zoster vaccine virus infection 27.11 9.65 13 326805 110 64171804
Complication associated with device 27.02 9.65 22 326796 15058 64156856
Fungal infection 27.02 9.65 279 326539 33972 64137942
Gastritis bacterial 27 9.65 18 326800 301 64171613
Necrosis 26.99 9.65 97 326721 8074 64163840
Xanthogranuloma 26.98 9.65 11 326807 60 64171854
Mouth ulceration 26.90 9.65 267 326551 32177 64139737
Sudden hearing loss 26.84 9.65 38 326780 1672 64170242
Paradoxical drug reaction 26.83 9.65 80 326738 6040 64165874
Hypersensitivity pneumonitis 26.81 9.65 54 326764 3178 64168736
Atypical fracture 26.77 9.65 24 326794 632 64171282
Surgery 26.74 9.65 65 326753 28148 64143766
Hepatic amoebiasis 26.72 9.65 12 326806 86 64171828
Retinal pigment epitheliopathy 26.65 9.65 19 326799 356 64171558
Helicobacter infection 26.62 9.65 102 326716 38260 64133654
Duodenal perforation 26.60 9.65 40 326778 1860 64170054
Gene mutation 26.58 9.65 42 326776 2040 64169874
Skin necrosis 26.54 9.65 143 326675 14186 64157728
Product monitoring error 26.53 9.65 74 326744 5380 64166534
Iron deficiency anaemia 26.52 9.65 196 326622 21693 64150221
Granuloma 26.50 9.65 84 326734 6557 64165357
Musculoskeletal disorder 26.45 9.65 31 326787 17875 64154039
Folliculitis 26.42 9.65 72 326746 30005 64141909
Gastric disorder 26.33 9.65 69 326749 29128 64142786
Idiopathic pulmonary fibrosis 26.32 9.65 59 326759 3741 64168173
Encephalitis viral 26.32 9.65 45 326773 2335 64169579
Impaired work ability 26.29 9.65 23 326795 15196 64156718
Skin discolouration 26.27 9.65 91 326727 35164 64136750
Malacoplakia vesicae 26.26 9.65 11 326807 65 64171849
Upper limb fracture 26.25 9.65 22 326796 14844 64157070
Glomerulonephritis rapidly progressive 26.20 9.65 33 326785 1295 64170619
Mycobacterium kansasii infection 26.15 9.65 17 326801 272 64171642
Sleep disorder due to a general medical condition 26.12 9.65 5 326813 8229 64163685
Myelitis 26.10 9.65 42 326776 2072 64169842
Malaise 26.06 9.65 1694 325124 394553 63777361
Ulcerative keratitis 25.99 9.65 52 326766 3045 64168869
Hyperplasia 25.98 9.65 30 326788 1074 64170840
Hypopyon 25.98 9.65 29 326789 1000 64170914
Mycotic endophthalmitis 25.92 9.65 12 326806 93 64171821
Renal infarct 25.89 9.65 45 326773 2366 64169548
Blood pressure diastolic increased 25.88 9.65 11 326807 10741 64161173
Lepromatous leprosy 25.85 9.65 11 326807 68 64171846
Drug level increased 25.78 9.65 276 326542 33920 64137994
Retroperitoneal abscess 25.77 9.65 18 326800 326 64171588
Product storage error 25.70 9.65 18 326800 13300 64158614
Mycobacterium fortuitum infection 25.62 9.65 15 326803 197 64171717
Rectal perforation 25.62 9.65 25 326793 735 64171179
Meningoencephalitis viral 25.59 9.65 19 326799 380 64171534
Chromoblastomycosis 25.58 9.65 11 326807 70 64171844
Cutaneous leishmaniasis 25.57 9.65 17 326801 283 64171631
Renal disorder 25.53 9.65 283 326535 35082 64136832
Renal tubular atrophy 25.53 9.65 35 326783 1494 64170420
Shock haemorrhagic 25.51 9.65 159 326659 16632 64155282
Mantle cell lymphoma refractory 25.50 9.65 12 326806 97 64171817
Musculoskeletal pain 25.43 9.65 276 326542 81018 64090896
Renal abscess 25.41 9.65 27 326791 880 64171034
Molluscum contagiosum 25.40 9.65 20 326798 438 64171476
Circulatory collapse 25.31 9.65 272 326546 33460 64138454
Amoebiasis 25.29 9.65 12 326806 99 64171815
Cell marker increased 25.24 9.65 23 326795 619 64171295
Gastroenteritis viral 25.22 9.65 38 326780 19691 64152223
Enterobacter infection 25.17 9.65 57 326761 3639 64168275
Evans syndrome 25.17 9.65 19 326799 390 64171524
Perinephric abscess 25.11 9.65 15 326803 205 64171709
Incorrect route of product administration 25.10 9.65 50 326768 23248 64148666
Biopsy kidney abnormal 25.08 9.65 14 326804 167 64171747
Pulmonary sepsis 25.06 9.65 51 326767 3024 64168890
Wound dehiscence 25.01 9.65 76 326742 5798 64166116
Diarrhoea haemorrhagic 24.99 9.65 118 326700 11109 64160805
Neonatal hypoacusis 24.98 9.65 8 326810 18 64171896
Escherichia urinary tract infection 24.98 9.65 124 326694 11913 64160001
Atypical pneumonia 24.94 9.65 71 326747 5223 64166691
Carpal tunnel syndrome 24.92 9.65 26 326792 15802 64156112
Blood immunoglobulin G decreased 24.90 9.65 47 326771 2636 64169278
Transient ischaemic attack 24.89 9.65 127 326691 44055 64127859
Morganella infection 24.80 9.65 28 326790 978 64170936
Accidental overdose 24.75 9.65 87 326731 33470 64138444
Hepatitis fulminant 24.71 9.65 79 326739 6195 64165719
Legionella infection 24.69 9.65 24 326794 702 64171212
Guillain-Barre syndrome 24.68 9.65 90 326728 7545 64164369
Medication error 24.68 9.65 150 326668 49816 64122098
Immunodeficiency common variable 24.66 9.65 16 326802 255 64171659
Dysphonia 24.64 9.65 136 326682 46246 64125668
Product complaint 24.64 9.65 15 326803 11939 64159975
Intervertebral discitis 24.64 9.65 58 326760 3799 64168115
Bronchitis 24.56 9.65 395 326423 108348 64063566
Acute kidney injury 24.45 9.65 1952 324866 447288 63724626
Anaplastic large-cell lymphoma 24.44 9.65 14 326804 176 64171738
Epidural lipomatosis 24.38 9.65 26 326792 851 64171063
Corneal deposits 24.29 9.65 18 326800 359 64171555
Device leakage 24.23 9.65 6 326812 8260 64163654
Pneumonia legionella 24.14 9.65 44 326774 2402 64169512
Auditory neuropathy spectrum disorder 24.12 9.65 8 326810 21 64171893
Palpitations 24.12 9.65 378 326440 104110 64067804
Disability 24.09 9.65 16 326802 12156 64159758
Systemic scleroderma 24.07 9.65 27 326791 936 64170978
Duodenal ulcer 24.04 9.65 140 326678 14295 64157619
Aphthous ulcer 24.04 9.65 129 326689 12777 64159137
Bursitis infective 23.97 9.65 30 326788 1170 64170744
Tachyarrhythmia 23.84 9.65 76 326742 5950 64165964
Stenotrophomonas infection 23.83 9.65 50 326768 3030 64168884
Herpes simplex hepatitis 23.75 9.65 19 326799 426 64171488
Poor quality sleep 23.74 9.65 37 326781 18914 64153000
Respiratory tract infection 23.74 9.65 292 326526 37115 64134799
Sensitivity to weather change 23.74 9.65 3 326815 6711 64165203
Viral haemorrhagic cystitis 23.72 9.65 35 326783 1600 64170314
Multiple sclerosis 23.71 9.65 37 326781 18904 64153010
Hepatitis viral 23.70 9.65 26 326792 879 64171035
Skin lesion 23.69 9.65 286 326532 36196 64135718
Gastric perforation 23.63 9.65 54 326764 3469 64168445
DNA antibody positive 23.62 9.65 16 326802 275 64171639
Panic attack 23.42 9.65 44 326774 20909 64151005
Microsporum infection 23.39 9.65 9 326809 41 64171873
Fusarium infection 23.36 9.65 34 326784 1535 64170379
Hepatitis C RNA increased 23.34 9.65 18 326800 382 64171532
Granulomatosis with polyangiitis 23.33 9.65 40 326778 2080 64169834
Diffuse alveolar damage 23.28 9.65 51 326767 3184 64168730
Ligament sprain 23.24 9.65 13 326805 10839 64161075
Ocular procedural complication 23.23 9.65 19 326799 440 64171474
Thyroiditis subacute 23.23 9.65 16 326802 283 64171631
Infection masked 23.23 9.65 12 326806 121 64171793
Macular fibrosis 23.16 9.65 23 326795 691 64171223
Neutropenic colitis 23.12 9.65 63 326755 4518 64167396
Needle issue 23.11 9.65 9 326809 9263 64162651
Obstructive airways disorder 23.11 9.65 52 326766 23133 64148781
Neuromyelitis optica spectrum disorder 23.10 9.65 25 326793 832 64171082
Anuria 23.08 9.65 170 326648 18794 64153120
Abscess fungal 23.07 9.65 15 326803 240 64171674
Tongue necrosis 23.04 9.65 9 326809 43 64171871
Plasmablastic lymphoma 22.98 9.65 18 326800 391 64171523
Blood cholesterol increased 22.83 9.65 154 326664 49912 64122002
Irritability 22.82 9.65 102 326716 36644 64135270
Salmonellosis 22.79 9.65 31 326787 1313 64170601
Scrotal ulcer 22.75 9.65 16 326802 293 64171621
Enterovesical fistula 22.73 9.65 26 326792 921 64170993
Ureteric stenosis 22.69 9.65 30 326788 1236 64170678
Exostosis 22.69 9.65 15 326803 11423 64160491
Lung lobectomy 22.65 9.65 12 326806 128 64171786
Lymphocyte stimulation test positive 22.65 9.65 28 326790 1078 64170836
Sexual dysfunction 22.62 9.65 3 326815 6468 64165446
Infected skin ulcer 22.61 9.65 48 326770 2932 64168982
Atrial fibrillation 22.57 9.65 677 326141 170412 64001502
Ureterolithiasis 22.51 9.65 50 326768 3151 64168763
Enterocolitis viral 22.48 9.65 16 326802 299 64171615
Ophthalmic herpes zoster 22.47 9.65 40 326778 2144 64169770
Duodenal ulcer repair 22.46 9.65 10 326808 70 64171844
Pulmonary mucormycosis 22.44 9.65 24 326794 788 64171126
Tongue disorder 22.43 9.65 17 326801 12063 64159851
Central obesity 22.35 9.65 32 326786 1423 64170491
Polyneuropathy 22.34 9.65 175 326643 19719 64152195
Endocarditis enterococcal 22.33 9.65 12 326806 132 64171782
Blood fibrinogen decreased 22.30 9.65 32 326786 1426 64170488
Product substitution issue 22.26 9.65 35 326783 17826 64154088
Herpes virus infection 22.25 9.65 76 326742 6168 64165746
Ear pain 22.21 9.65 60 326758 25076 64146838
Papilloma viral infection 22.20 9.65 32 326786 1432 64170482
Herpes zoster meningitis 22.18 9.65 12 326806 134 64171780
Rash pruritic 22.17 9.65 185 326633 57219 64114695
Exophthalmos 22.07 9.65 33 326785 1527 64170387
Hallucination 22.02 9.65 249 326569 72539 64099375
Pulmonary necrosis 22.02 9.65 19 326799 475 64171439
Diffuse large B-cell lymphoma stage IV 21.98 9.65 19 326799 476 64171438
Shock 21.94 9.65 293 326525 37947 64133967
Pulmonary air leakage 21.93 9.65 13 326805 175 64171739
Cellulitis gangrenous 21.79 9.65 15 326803 265 64171649
Panniculitis 21.75 9.65 96 326722 8783 64163131
Synovectomy 21.75 9.65 14 326804 220 64171694
Continuous haemodiafiltration 21.73 9.65 37 326781 1913 64170001
Joint tuberculosis 21.72 9.65 12 326806 140 64171774
Glucose tolerance impaired 21.72 9.65 77 326741 6366 64165548
IIIrd nerve paralysis 21.69 9.65 27 326791 1047 64170867
Tuberculosis gastrointestinal 21.69 9.65 19 326799 485 64171429
Neutrophilic panniculitis 21.66 9.65 10 326808 77 64171837
Rheumatoid vasculitis 21.65 9.65 18 326800 427 64171487
Systemic inflammatory response syndrome 21.64 9.65 106 326712 10129 64161785
Diffuse panbronchiolitis 21.61 9.65 6 326812 6 64171908
Spleen atrophy 21.61 9.65 6 326812 6 64171908
Metaphyseal corner fracture 21.61 9.65 8 326810 32 64171882
Tubulointerstitial nephritis and uveitis syndrome 21.60 9.65 15 326803 269 64171645
Laboratory test abnormal 21.59 9.65 57 326761 24006 64147908
Apnoea 21.59 9.65 13 326805 10409 64161505
Isosporiasis 21.55 9.65 11 326807 108 64171806
Macular pseudohole 21.45 9.65 5 326813 0 64171914
Polyglandular autoimmune syndrome type III 21.45 9.65 5 326813 0 64171914
Vision blurred 21.43 9.65 325 326493 89991 64081923
Monoclonal B-cell lymphocytosis 21.37 9.65 9 326809 54 64171860
Back disorder 21.35 9.65 12 326806 9978 64161936
Cytomegalovirus mucocutaneous ulcer 21.33 9.65 10 326808 80 64171834
Respiratory tract infection fungal 21.33 9.65 27 326791 1065 64170849
Kidney fibrosis 21.32 9.65 48 326770 3053 64168861
Disseminated trichosporonosis 21.23 9.65 10 326808 81 64171833
Bone infarction 21.18 9.65 17 326801 383 64171531
Poor venous access 21.17 9.65 19 326799 12398 64159516
Pseudomonal sepsis 21.17 9.65 66 326752 5106 64166808
Musculoskeletal discomfort 21.15 9.65 31 326787 16246 64155668
Parotid abscess 21.14 9.65 6 326812 7 64171907
Vascular pseudoaneurysm 21.08 9.65 48 326770 3076 64168838
Erythema infectiosum 21.07 9.65 13 326805 189 64171725
Extradural abscess 21.01 9.65 28 326790 1163 64170751
Cushing's syndrome 20.98 9.65 25 326793 926 64170988
Meningomyelitis herpes 20.97 9.65 9 326809 57 64171857
Acanthosis 20.96 9.65 17 326801 389 64171525
Sinusitis aspergillus 20.89 9.65 13 326805 192 64171722
Urinary incontinence 20.89 9.65 103 326715 36048 64135866
Megakaryocytes increased 20.82 9.65 10 326808 85 64171829
Colitis ulcerative 20.82 9.65 193 326625 22835 64149079
Tooth infection 20.80 9.65 26 326792 14575 64157339
Hypomagnesaemia 20.74 9.65 108 326710 37268 64134646
Gastropleural fistula 20.71 9.65 9 326809 59 64171855
Drug level fluctuating 20.69 9.65 21 326797 648 64171266
Mucinous adenocarcinoma of appendix 20.68 9.65 7 326811 20 64171894
Bone erosion 20.67 9.65 17 326801 11578 64160336
Blood test abnormal 20.67 9.65 21 326797 12922 64158992
Cataract subcapsular 20.66 9.65 24 326794 865 64171049
Arterial thrombosis 20.63 9.65 41 326777 2389 64169525
Dermatophytosis of nail 20.60 9.65 12 326806 156 64171758
Pulmonary thrombosis 20.58 9.65 14 326804 10504 64161410
Fungal sepsis 20.55 9.65 33 326785 1625 64170289
Head deformity 20.52 9.65 8 326810 38 64171876
Corynebacterium infection 20.52 9.65 25 326793 948 64170966
Reversible cerebral vasoconstriction syndrome 20.47 9.65 40 326778 2302 64169612
Superior sagittal sinus thrombosis 20.46 9.65 25 326793 951 64170963
Rash vesicular 20.42 9.65 63 326755 4847 64167067
Drug dependence 20.37 9.65 93 326725 33219 64138695
Tularaemia 20.33 9.65 10 326808 90 64171824
Antiphospholipid syndrome 20.31 9.65 32 326786 1550 64170364
Skin laceration 20.31 9.65 60 326758 24357 64147557
Pulse absent 20.22 9.65 10 326808 8936 64162978
Infective pulmonary exacerbation of cystic fibrosis 20.17 9.65 18 326800 11778 64160136
Femoral hernia incarcerated 20.17 9.65 22 326796 739 64171175
Failure to thrive 20.16 9.65 14 326804 10390 64161524
Eczema herpeticum 20.16 9.65 13 326805 205 64171709
Tooth disorder 20.15 9.65 53 326765 22349 64149565
Mantle cell lymphoma recurrent 20.14 9.65 18 326800 472 64171442
Prinzmetal angina 20.13 9.65 31 326787 1472 64170442
Substance abuse 20.09 9.65 11 326807 9281 64162633
Aspergilloma 20.08 9.65 18 326800 474 64171440
Endotoxic shock 19.96 9.65 7 326811 23 64171891
Dermatomyositis 19.93 9.65 44 326774 2762 64169152
Electrocardiogram QRS complex prolonged 19.91 9.65 11 326807 9233 64162681
Subileus 19.90 9.65 63 326755 4914 64167000
Dystonia 19.89 9.65 41 326777 18824 64153090
Laryngitis 19.88 9.65 16 326802 11015 64160899
Alveolitis 19.87 9.65 52 326766 3640 64168274
Giant cell arteritis 19.73 9.65 39 326779 2264 64169650
Blood creatinine increased 19.72 9.65 859 325959 134923 64036991
Blister 19.68 9.65 290 326528 80677 64091237
Henoch-Schonlein purpura 19.68 9.65 38 326780 2168 64169746
Uterine perforation 19.64 9.65 3 326815 5817 64166097
Malignant neoplasm progression 19.62 9.65 728 326090 112143 64059771
Still's disease 19.55 9.65 6 326812 11 64171903
Infarction 19.53 9.65 54 326764 3906 64168008
Leukaemic infiltration 19.43 9.65 11 326807 135 64171779
Lymphadenitis bacterial 19.42 9.65 8 326810 45 64171869
Anal prolapse 19.42 9.65 9 326809 70 64171844
Premature rupture of membranes 19.41 9.65 52 326766 3692 64168222
Body height decreased 19.39 9.65 7 326811 7547 64164367
Cutaneous malacoplakia 19.31 9.65 9 326809 71 64171843
Concussion 19.30 9.65 8 326810 7930 64163984
Ophthalmic herpes simplex 19.29 9.65 19 326799 565 64171349
Therapeutic response shortened 19.29 9.65 14 326804 10156 64161758
Depressed mood 19.28 9.65 125 326693 40887 64131027
Nuchal rigidity 19.27 9.65 24 326794 931 64170983
Coagulation test abnormal 19.27 9.65 26 326792 1093 64170821
Aortic valve stenosis 19.26 9.65 59 326759 4521 64167393
Paraneoplastic pemphigus 19.26 9.65 10 326808 102 64171812
Ageusia 19.26 9.65 25 326793 13788 64158126
Duodenal ulcer perforation 19.24 9.65 100 326718 34525 64137389
Pulmonary artery thrombosis 19.23 9.65 27 326791 1179 64170735
Cyclosporidium infection 19.21 9.65 6 326812 12 64171902
Treatment noncompliance 19.21 9.65 135 326683 43347 64128567
Small cell lung cancer 19.21 9.65 42 326776 2619 64169295
Erysipelas 19.17 9.65 94 326724 8987 64162927
Bronchostenosis 19.15 9.65 19 326799 570 64171344
Bradyphrenia 19.11 9.65 12 326806 9394 64162520
Osteomyelitis bacterial 19.08 9.65 17 326801 444 64171470
Purulent discharge 19.05 9.65 66 326752 5395 64166519
Postoperative wound infection 19.04 9.65 103 326715 10233 64161681
Depressed level of consciousness 19.00 9.65 294 326524 81142 64090772
Hypochromic anaemia 18.97 9.65 39 326779 2329 64169585
Fungal test positive 18.95 9.65 24 326794 947 64170967
Scleral disorder 18.95 9.65 12 326806 183 64171731
Metastases to lymph nodes 18.95 9.65 91 326727 8626 64163288
Staphylococcal bacteraemia 18.95 9.65 103 326715 10252 64161662
Post transplant distal limb syndrome 18.93 9.65 18 326800 512 64171402
Eye infection staphylococcal 18.93 9.65 10 326808 106 64171808
Mononeuropathy multiplex 18.91 9.65 15 326803 332 64171582
Glossopharyngeal nerve paralysis 18.89 9.65 6 326812 13 64171901
Asteatosis 18.89 9.65 9 326809 75 64171839
Cytomegalovirus nephritis 18.89 9.65 11 326807 143 64171771
Intentional dose omission 18.87 9.65 3 326815 5649 64166265
Mediastinal abscess 18.86 9.65 8 326810 49 64171865
Inferior vena cava stenosis 18.86 9.65 8 326810 49 64171865
Lupus enteritis 18.86 9.65 8 326810 49 64171865
Leishmaniasis 18.84 9.65 15 326803 334 64171580
Rectal cancer 18.81 9.65 43 326775 2763 64169151
Rectal ulcer 18.80 9.65 34 326784 1845 64170069
Acute graft versus host disease in liver 18.79 9.65 32 326786 1655 64170259
Stress fracture 18.78 9.65 67 326751 5557 64166357
Septic encephalopathy 18.78 9.65 13 326805 232 64171682
Phaeohyphomycotic brain abscess 18.73 9.65 8 326810 50 64171864
Bursitis infective staphylococcal 18.69 9.65 9 326809 77 64171837
Glomerulonephritis 18.67 9.65 44 326774 2884 64169030
Ileal stenosis 18.64 9.65 36 326782 2054 64169860
Thyroid disorder 18.64 9.65 19 326799 11673 64160241
Chronic myelomonocytic leukaemia 18.59 9.65 21 326797 734 64171180
Acute graft versus host disease in intestine 18.58 9.65 50 326768 3559 64168355
Epstein-Barr virus antibody positive 18.57 9.65 19 326799 592 64171322
Increased tendency to bruise 18.54 9.65 12 326806 9243 64162671
Gastric stenosis 18.53 9.65 10 326808 111 64171803
B-lymphocyte count decreased 18.52 9.65 26 326792 1135 64170779
Lymphatic fistula 18.52 9.65 21 326797 737 64171177
Intestinal pseudo-obstruction 18.52 9.65 35 326783 1965 64169949
Oral mucosa erosion 18.51 9.65 32 326786 1675 64170239
Sinus bradycardia 18.51 9.65 57 326761 22836 64149078
Hepatic artery thrombosis 18.48 9.65 14 326804 289 64171625
Hepatitis C 18.46 9.65 107 326711 10908 64161006
Relapsing fever 18.43 9.65 15 326803 345 64171569
Pancreas transplant rejection 18.36 9.65 14 326804 292 64171622
Hyperglycaemic hyperosmolar nonketotic syndrome 18.35 9.65 32 326786 1687 64170227
Cow pox 18.35 9.65 7 326811 31 64171883
Central nervous system fungal infection 18.34 9.65 16 326802 406 64171508
Hepatic atrophy 18.34 9.65 16 326802 406 64171508
Atypical haemolytic uraemic syndrome 18.33 9.65 20 326798 672 64171242
Candida endophthalmitis 18.31 9.65 11 326807 152 64171762
Encephalitis cytomegalovirus 18.30 9.65 24 326794 981 64170933
Mucosal ulceration 18.24 9.65 32 326786 1695 64170219
Listeria encephalitis 18.24 9.65 14 326804 295 64171619
Therapy change 18.23 9.65 5 326813 6429 64165485
Infectious thyroiditis 18.23 9.65 10 326808 115 64171799
Human herpesvirus 6 encephalitis 18.21 9.65 16 326802 410 64171504
Femoral neck fracture 18.20 9.65 90 326728 8634 64163280
Granulomatous rosacea 18.19 9.65 12 326806 197 64171717
Papule 18.17 9.65 72 326746 6278 64165636
Renal cell carcinoma 18.11 9.65 70 326748 6034 64165880
Respiratory alkalosis 18.10 9.65 52 326766 3845 64168069
Superinfection bacterial 18.03 9.65 26 326792 1164 64170750
Gastrointestinal necrosis 17.99 9.65 61 326757 4931 64166983
Eye irritation 17.98 9.65 33 326785 15823 64156091
Cryptococcal cutaneous infection 17.94 9.65 11 326807 158 64171756
Oliguria 17.93 9.65 131 326687 14445 64157469
Post procedural bile leak 17.93 9.65 15 326803 359 64171555
Complications of transplanted heart 17.92 9.65 14 326804 303 64171611
Necrotising colitis 17.90 9.65 23 326795 921 64170993
Cystitis viral 17.88 9.65 19 326799 619 64171295
IVth nerve paralysis 17.88 9.65 11 326807 159 64171755
Stevens-Johnson syndrome 17.86 9.65 258 326560 33991 64137923
Protothecosis 17.83 9.65 7 326811 34 64171880
Aphonia 17.80 9.65 11 326807 8686 64163228
Aortic aneurysm rupture 17.79 9.65 26 326792 1178 64170736
Hyperuricaemia 17.73 9.65 100 326718 10091 64161823
Gastroenteritis adenovirus 17.68 9.65 13 326805 256 64171658
Atrioventricular block first degree 17.62 9.65 17 326801 10717 64161197
Muscle rigidity 17.57 9.65 39 326779 17434 64154480
Herpes zoster cutaneous disseminated 17.55 9.65 15 326803 370 64171544
Lymphangioma 17.51 9.65 6 326812 18 64171896
Corneal scar 17.51 9.65 13 326805 260 64171654
Stress ulcer 17.51 9.65 10 326808 125 64171789
Renal adenoma 17.51 9.65 7 326811 36 64171878
Glomerulosclerosis 17.50 9.65 23 326795 942 64170972
Coronary artery bypass 17.48 9.65 4 326814 5811 64166103
Eye infection fungal 17.42 9.65 16 326802 435 64171479
Myeloproliferative neoplasm 17.40 9.65 22 326796 867 64171047
Complement factor decreased 17.39 9.65 8 326810 61 64171853
Melanaemia 17.39 9.65 8 326810 61 64171853
Venoocclusive disease 17.38 9.65 52 326766 3933 64167981
Melaena 17.37 9.65 374 326444 53174 64118740
Cerebellar stroke 17.36 9.65 16 326802 437 64171477
Hirsutism 17.35 9.65 23 326795 950 64170964
Coinfection 17.35 9.65 7 326811 37 64171877
Uterine haematoma 17.27 9.65 6 326812 19 64171895
Tendon pain 17.26 9.65 59 326759 4789 64167125
Anti-platelet antibody positive 17.26 9.65 13 326805 266 64171648
Paresis 17.25 9.65 48 326770 3484 64168430
Conjunctival oedema 17.23 9.65 24 326794 1040 64170874
Pseudarthrosis 17.22 9.65 13 326805 267 64171647
Dysplasia 17.17 9.65 25 326793 1129 64170785
Phagocytosis 17.16 9.65 4 326814 0 64171914
Peritonitis lupus 17.16 9.65 4 326814 0 64171914
Tracheal ulcer 17.16 9.65 4 326814 0 64171914
Cerebellar infarction 17.11 9.65 46 326772 3273 64168641
Meningoencephalitis amoebic 17.10 9.65 10 326808 131 64171783
Veillonella infection 17.05 9.65 7 326811 39 64171875
Helicobacter sepsis 17.04 9.65 6 326812 20 64171894
Back injury 17.04 9.65 9 326809 7748 64164166
Second primary malignancy 17.01 9.65 114 326704 12223 64159691
Generalised oedema 16.99 9.65 171 326647 20682 64151232
Gouty tophus 16.98 9.65 14 326804 328 64171586
Gastric ulcer haemorrhage 16.98 9.65 84 326734 8059 64163855
Oesophageal fibrosis 16.97 9.65 11 326807 175 64171739
Periodontitis 16.96 9.65 53 326765 4106 64167808
Secondary adrenocortical insufficiency 16.91 9.65 37 326781 2308 64169606
Subarachnoid haemorrhage 16.90 9.65 155 326663 18283 64153631
Endothelial dysfunction 16.86 9.65 11 326807 177 64171737
Orbital infection 16.86 9.65 8 326810 66 64171848
Myalgia 16.86 9.65 645 326173 157972 64013942
Histiocytic sarcoma 16.86 9.65 8 326810 66 64171848
Salivary hypersecretion 16.81 9.65 22 326796 12091 64159823
Haematochezia 16.80 9.65 448 326370 65925 64105989
Blood urine present 16.80 9.65 43 326775 18297 64153617
Abscess bacterial 16.78 9.65 20 326798 741 64171173
Chronic hepatitis 16.77 9.65 26 326792 1242 64170672
Tracheobronchitis 16.77 9.65 31 326787 1711 64170203
Osteomyelitis salmonella 16.76 9.65 7 326811 41 64171873
Duodenal ulcer haemorrhage 16.74 9.65 70 326748 6255 64165659
Thoracic vertebral fracture 16.73 9.65 56 326762 4497 64167417
Leukoderma 16.72 9.65 10 326808 137 64171777
Pancreatic pseudocyst haemorrhage 16.71 9.65 5 326813 8 64171906
Respiratory gas exchange disorder 16.69 9.65 20 326798 745 64171169
Seroma 16.66 9.65 34 326784 2020 64169894
Mesangioproliferative glomerulonephritis 16.66 9.65 8 326810 68 64171846
Factitious disorder 16.65 9.65 10 326808 138 64171776
Reticulocytopenia 16.65 9.65 11 326807 181 64171733
Acute hepatic failure 16.64 9.65 204 326614 25908 64146006
Injection site discolouration 16.60 9.65 7 326811 6868 64165046
Device use error 16.60 9.65 6 326812 6465 64165449
Disseminated strongyloidiasis 16.59 9.65 9 326809 101 64171813
Seasonal allergy 16.58 9.65 21 326797 11705 64160209
Abnormal behaviour 16.57 9.65 101 326717 33521 64138393
Hypoproteinaemia 16.56 9.65 46 326772 3336 64168578
CSF protein increased 16.53 9.65 24 326794 1081 64170833
Cyst 16.53 9.65 22 326796 12005 64159909
Neoplasm skin 16.47 9.65 25 326793 1172 64170742
Ganglioneuroma 16.47 9.65 10 326808 141 64171773
Nightmare 16.45 9.65 53 326765 20940 64150974
Pneumonia haemophilus 16.43 9.65 22 326796 918 64170996
Adenomatous polyposis coli 16.40 9.65 11 326807 186 64171728
Quadrantanopia 16.40 9.65 11 326807 186 64171728
Non-Hodgkin's lymphoma 16.37 9.65 28 326790 1453 64170461
Pharyngitis streptococcal 16.35 9.65 12 326806 8656 64163258
Reticulin increased 16.35 9.65 5 326813 9 64171905
Hepatitis B DNA increased 16.33 9.65 18 326800 612 64171302
Prostatic abscess 16.32 9.65 14 326804 347 64171567
Gastrointestinal mucosa hyperaemia 16.30 9.65 15 326803 409 64171505
Autoimmune hepatitis 16.28 9.65 97 326721 9987 64161927
Gastrointestinal amyloidosis 16.27 9.65 8 326810 72 64171842
Jejunal stenosis 16.27 9.65 8 326810 72 64171842
Aspergillus test positive 16.26 9.65 19 326799 689 64171225
Thrombosis in device 16.25 9.65 3 326815 5068 64166846
Encephalomyelitis 16.24 9.65 11 326807 189 64171725
Haematoma infection 16.24 9.65 26 326792 1277 64170637
Large intestine infection 16.23 9.65 39 326779 2589 64169325
Kidney infection 16.20 9.65 42 326776 17796 64154118
Arthritis 16.20 9.65 313 326505 83501 64088413
Gastroenteritis bacterial 16.15 9.65 11 326807 191 64171723
Lip swelling 16.10 9.65 239 326579 31668 64140246
Retinal infiltrates 16.09 9.65 7 326811 46 64171868
Herpes simplex encephalitis 16.07 9.65 18 326800 623 64171291
Hepatic infection fungal 16.05 9.65 11 326807 193 64171721
Transplant abscess 16.01 9.65 6 326812 25 64171889
Tooth dislocation 16.01 9.65 6 326812 25 64171889
Retroperitoneal neoplasm 16.01 9.65 6 326812 25 64171889
Picornavirus infection 16.01 9.65 5 326813 10 64171904
Tooth fracture 15.98 9.65 16 326802 9911 64162003
Intestinal fistula 15.98 9.65 25 326793 1204 64170710
Central nervous system immune reconstitution inflammatory response 15.97 9.65 7 326811 47 64171867
Rheumatoid factor increased 15.96 9.65 27 326791 1389 64170525
Transaminases increased 15.95 9.65 316 326502 44278 64127636
Exposure via body fluid 15.95 9.65 12 326806 245 64171669
Substance-induced mood disorder 15.93 9.65 9 326809 110 64171804
Device occlusion 15.93 9.65 16 326802 9897 64162017
Graft versus host disease in lung 15.90 9.65 20 326798 784 64171130
Candida sepsis 15.89 9.65 35 326783 2193 64169721
Oesophageal ulcer 15.87 9.65 68 326750 6142 64165772
Hypertrichosis 15.83 9.65 24 326794 1124 64170790
Myocardiac abscess 15.83 9.65 6 326812 26 64171888
Blast crisis in myelogenous leukaemia 15.80 9.65 20 326798 789 64171125
Antithrombin III decreased 15.80 9.65 15 326803 426 64171488
Hypersensitivity vasculitis 15.74 9.65 72 326746 6689 64165225
Acute monocytic leukaemia 15.74 9.65 15 326803 428 64171486
Blood pressure ambulatory increased 15.72 9.65 7 326811 49 64171865
Rectosigmoid cancer 15.71 9.65 12 326806 251 64171663
Ileal perforation 15.70 9.65 21 326797 875 64171039
Tardive dyskinesia 15.70 9.65 14 326804 9164 64162750
Cryptococcus test positive 15.69 9.65 5 326813 11 64171903
Genitourinary tract infection 15.67 9.65 12 326806 252 64171662
Vasogenic cerebral oedema 15.66 9.65 22 326796 961 64170953
Removal of renal transplant 15.65 9.65 6 326812 27 64171887
Neutrophil morphology abnormal 15.63 9.65 8 326810 79 64171835
Renal tubular injury 15.63 9.65 24 326794 1137 64170777
Ureaplasma infection 15.62 9.65 19 326799 719 64171195
Herpes zoster oticus 15.61 9.65 14 326804 369 64171545
Graft versus host disease in liver 15.57 9.65 28 326790 1513 64170401
Grip strength decreased 15.55 9.65 22 326796 11702 64160212
Small intestinal obstruction 15.52 9.65 64 326754 23509 64148405
Weight bearing difficulty 15.51 9.65 39 326779 2664 64169250
Pyelonephritis chronic 15.51 9.65 12 326806 256 64171658
Coxsackie viral infection 15.49 9.65 7 326811 51 64171863
Tooth abscess 15.48 9.65 29 326789 13797 64158117
Herpangina 15.48 9.65 6 326812 28 64171886
Chorioretinal folds 15.48 9.65 6 326812 28 64171886
Inappropriate antidiuretic hormone secretion 15.47 9.65 177 326641 22112 64149802
Brain compression 15.47 9.65 16 326802 505 64171409
Soft tissue mass 15.47 9.65 21 326797 888 64171026
Tissue infiltration 15.47 9.65 17 326801 576 64171338
Product use issue 15.46 9.65 620 326198 151095 64020819
Urinary tract infection bacterial 15.41 9.65 59 326759 5062 64166852
Pancreatic leak 15.39 9.65 5 326813 12 64171902
Liver transplant failure 15.39 9.65 9 326809 118 64171796
Iris hypopigmentation 15.37 9.65 7 326811 52 64171862
Haemodialysis 15.37 9.65 143 326675 16934 64154980
Calculus urinary 15.37 9.65 31 326787 1826 64170088
Neutrophilia 15.37 9.65 71 326747 6623 64165291
Purulence 15.35 9.65 32 326786 1930 64169984
Speech disorder 15.33 9.65 164 326654 48277 64123637
Abdominal abscess 15.32 9.65 68 326750 6236 64165678
Cellulitis 15.31 9.65 600 326218 93057 64078857
Pneumaturia 15.31 9.65 6 326812 29 64171885
Rash pustular 15.27 9.65 94 326724 9791 64162123
Osteomyelitis fungal 15.23 9.65 12 326806 263 64171651
Haemolysis 15.22 9.65 102 326716 10937 64160977
Epstein-Barr virus antigen positive 15.21 9.65 8 326810 84 64171830
Lupus myocarditis 15.21 9.65 8 326810 84 64171830
Intestinal ulcer 15.17 9.65 29 326789 1642 64170272
Poikiloderma 15.16 9.65 13 326805 322 64171592
Angina unstable 15.16 9.65 35 326783 15432 64156482
Blood pressure decreased 15.14 9.65 327 326491 85872 64086042
Neurosarcoidosis 15.13 9.65 13 326805 323 64171591
Klebsiella sepsis 15.13 9.65 38 326780 2594 64169320
Precursor T-lymphoblastic lymphoma/leukaemia 15.13 9.65 8 326810 85 64171829
Blood lactate dehydrogenase 15.11 9.65 5 326813 13 64171901
Coronary arterial stent insertion 15.08 9.65 5 326813 5687 64166227
Lymphoma transformation 15.08 9.65 11 326807 214 64171700
Bowen's disease 15.06 9.65 9 326809 123 64171791
Encephalitis autoimmune 15.06 9.65 31 326787 1853 64170061
Haemophilus infection 15.05 9.65 31 326787 1854 64170060
Passenger lymphocyte syndrome 15.05 9.65 8 326810 86 64171828
Sequestrectomy 15.04 9.65 20 326798 829 64171085
Mood altered 14.99 9.65 37 326781 15942 64155972
Chronic graft versus host disease in skin 14.99 9.65 26 326792 1365 64170549
Hyposplenism 14.94 9.65 4 326814 3 64171911
Paraneoplastic arthritis 14.94 9.65 4 326814 3 64171911
Chronic eosinophilic rhinosinusitis 14.94 9.65 4 326814 3 64171911
Infusion site extravasation 14.92 9.65 8 326810 6829 64165085
Dry eye 14.92 9.65 86 326732 28933 64142981
Symblepharon 14.91 9.65 10 326808 169 64171745
Hepatitis infectious mononucleosis 14.88 9.65 9 326809 126 64171788
Sphincter of Oddi dysfunction 14.88 9.65 14 326804 393 64171521
Injection site induration 14.83 9.65 14 326804 8918 64162996
Type 3 diabetes mellitus 14.83 9.65 6 326812 32 64171882
Cutaneous T-cell lymphoma stage IV 14.83 9.65 6 326812 32 64171882
Serous retinal detachment 14.83 9.65 18 326800 680 64171234
Coronary artery occlusion 14.81 9.65 30 326788 13861 64158053
Ejection fraction decreased 14.80 9.65 85 326733 28622 64143292
Chronic obstructive pulmonary disease 14.76 9.65 262 326556 70786 64101128
Psychomotor hyperactivity 14.74 9.65 32 326786 14419 64157495
Cystitis escherichia 14.70 9.65 15 326803 466 64171448
Blood pressure abnormal 14.69 9.65 32 326786 14403 64157511
Creatinine renal clearance decreased 14.65 9.65 32 326786 14389 64157525
Metastatic bronchial carcinoma 14.65 9.65 11 326807 224 64171690
Spinal fracture 14.65 9.65 129 326689 15045 64156869
Anal abscess 14.64 9.65 76 326742 7432 64164482
Papillary renal cell carcinoma 14.63 9.65 9 326809 130 64171784
Cutaneous T-cell lymphoma recurrent 14.62 9.65 7 326811 59 64171855
Portal vein thrombosis 14.61 9.65 57 326761 4934 64166980
Citrobacter infection 14.61 9.65 19 326799 770 64171144
Keratitis fungal 14.61 9.65 10 326808 175 64171739
Subclavian artery embolism 14.60 9.65 5 326813 15 64171899
Drug-induced liver injury 14.58 9.65 330 326488 47313 64124601
New onset diabetes after transplantation 14.58 9.65 9 326809 131 64171783
Haemorrhagic diathesis 14.57 9.65 61 326757 5453 64166461
Acanthamoeba infection 14.57 9.65 15 326803 471 64171443
Septic arthritis staphylococcal 14.54 9.65 18 326800 694 64171220
Anorectal varices 14.53 9.65 6 326812 34 64171880
Abscess rupture 14.53 9.65 12 326806 282 64171632
Hypereosinophilic syndrome 14.49 9.65 15 326803 474 64171440
Emphysematous pyelonephritis 14.48 9.65 11 326807 228 64171686
Tuberculosis of central nervous system 14.47 9.65 14 326804 407 64171507
Vertigo 14.46 9.65 211 326607 58800 64113114
Idiopathic interstitial pneumonia 14.46 9.65 10 326808 178 64171736
Pneumonitis chemical 14.45 9.65 13 326805 344 64171570
Status asthmaticus 14.45 9.65 21 326797 947 64170967
Foetal death 14.44 9.65 64 326754 5866 64166048
Facial paresis 14.43 9.65 56 326762 4836 64167078
Nodal marginal zone B-cell lymphoma 14.41 9.65 4 326814 4 64171910
Pneumocystis test positive 14.41 9.65 4 326814 4 64171910
Acid fast bacilli infection 14.40 9.65 9 326809 134 64171780
Enterocolitis bacterial 14.36 9.65 15 326803 479 64171435
Ocular vasculitis 14.36 9.65 5 326813 16 64171898
Infection protozoal 14.36 9.65 5 326813 16 64171898
Faciobrachial dystonic seizure 14.36 9.65 5 326813 16 64171898
Non-alcoholic steatohepatitis 14.31 9.65 31 326787 1921 64169993
Blood sodium decreased 14.30 9.65 89 326729 29393 64142521
Pneumonia staphylococcal 14.29 9.65 52 326766 4354 64167560
Deformity 14.29 9.65 7 326811 6290 64165624
Metastasis 14.28 9.65 62 326756 5633 64166281
Nail pigmentation 14.24 9.65 12 326806 290 64171624
Mucosal haemorrhage 14.24 9.65 34 326784 2247 64169667
Pre-eclampsia 14.24 9.65 66 326752 6165 64165749
Gallbladder necrosis 14.23 9.65 7 326811 63 64171851
Device breakage 14.22 9.65 14 326804 8741 64163173
Gastrointestinal erosion 14.22 9.65 21 326797 961 64170953
Lung opacity 14.20 9.65 42 326776 3157 64168757
Neutrophil count decreased 14.17 9.65 501 326317 76695 64095219
Atypical mycobacterial pneumonia 14.17 9.65 9 326809 138 64171776
Alcohol use 14.17 9.65 3 326815 4599 64167315
Pleural infection bacterial 14.13 9.65 5 326813 17 64171897
Nerve injury 14.04 9.65 11 326807 7674 64164240
Dry throat 14.03 9.65 7 326811 6225 64165689
Serum ferritin increased 14.02 9.65 82 326736 8386 64163528
Blood iron decreased 14.01 9.65 25 326793 12117 64159797
Soft tissue infection 14.01 9.65 42 326776 3181 64168733
Hormone-refractory prostate cancer 13.99 9.65 13 326805 359 64171555
Muscle atrophy 13.96 9.65 91 326727 9667 64162247
Non-cardiac chest pain 13.96 9.65 14 326804 8666 64163248
Meningitis enteroviral 13.95 9.65 7 326811 66 64171848
Intrauterine infection 13.95 9.65 7 326811 66 64171848
Necrotising scleritis 13.95 9.65 10 326808 189 64171725
Enterovirus myocarditis 13.94 9.65 4 326814 5 64171909
Herpes zoster reactivation 13.94 9.65 8 326810 101 64171813
Nosocomial infection 13.93 9.65 36 326782 2501 64169413
Metastatic malignant melanoma 13.89 9.65 36 326782 2505 64169409
Vasculitic rash 13.89 9.65 31 326787 1960 64169954
Bacillus infection 13.87 9.65 18 326800 728 64171186
Chronic gastritis 13.87 9.65 42 326776 3198 64168716
Cranial nerve palsies multiple 13.87 9.65 8 326810 102 64171812
Chronic graft versus host disease in eye 13.86 9.65 7 326811 67 64171847
Optic discs blurred 13.86 9.65 7 326811 67 64171847
Haematuria 13.85 9.65 403 326415 60068 64111846
Hypozincaemia 13.85 9.65 6 326812 39 64171875
Cerebral haemorrhage 13.85 9.65 348 326470 50742 64121172
Chorioretinitis 13.84 9.65 17 326801 650 64171264
Extrapulmonary tuberculosis 13.84 9.65 13 326805 364 64171550
Intestinal villi atrophy 13.81 9.65 13 326805 365 64171549
Neuroendocrine carcinoma of the skin 13.80 9.65 21 326797 987 64170927
Herpes simplex viraemia 13.77 9.65 11 326807 246 64171668
Toothache 13.74 9.65 44 326774 17415 64154499
Alpha tumour necrosis factor increased 13.72 9.65 6 326812 40 64171874
Viral cardiomyopathy 13.72 9.65 6 326812 40 64171874
Rectal cancer metastatic 13.71 9.65 14 326804 435 64171479
Osteitis 13.71 9.65 45 326773 3577 64168337
Pain in jaw 13.71 9.65 136 326682 40619 64131295
Parkinsonism 13.71 9.65 33 326785 14340 64157574
Large intestine erosion 13.70 9.65 5 326813 19 64171895
Gingival cancer 13.70 9.65 5 326813 19 64171895
Burkitt's lymphoma stage III 13.70 9.65 5 326813 19 64171895
Vaginal haemorrhage 13.70 9.65 51 326767 19293 64152621
Autoimmune colitis 13.70 9.65 25 326793 1366 64170548
Vulval ulceration 13.68 9.65 9 326809 147 64171767
Oral herpes 13.66 9.65 172 326646 21980 64149934
Infusion site erythema 13.65 9.65 9 326809 6864 64165050
Localised infection 13.64 9.65 93 326725 30068 64141846
Tinnitus 13.64 9.65 109 326709 34024 64137890
Atrioventricular block 13.63 9.65 25 326793 11990 64159924
Emotional disorder 13.63 9.65 27 326791 12580 64159334
Squamous cell carcinoma of lung 13.61 9.65 31 326787 1987 64169927
Acanthoma 13.60 9.65 6 326812 41 64171873
Transient hypogammaglobulinaemia of infancy 13.60 9.65 6 326812 41 64171873
N-telopeptide urine increased 13.60 9.65 6 326812 41 64171873
Ankylosing spondylitis 13.56 9.65 13 326805 8221 64163693
Gingivitis ulcerative 13.55 9.65 11 326807 252 64171662
Dehiscence 13.54 9.65 8 326810 107 64171807
Bullous impetigo 13.53 9.65 4 326814 6 64171908
Cholangitis sclerosing 13.52 9.65 30 326788 1889 64170025
Corneal disorder 13.52 9.65 31 326787 1996 64169918
Vogt-Koyanagi-Harada disease 13.51 9.65 10 326808 199 64171715
Autoimmune thyroiditis 13.51 9.65 44 326774 3484 64168430
Vagus nerve paralysis 13.51 9.65 5 326813 20 64171894
Myocardial calcification 13.48 9.65 6 326812 42 64171872
JC virus CSF test positive 13.47 9.65 9 326809 151 64171763
Pulmonary haemorrhage 13.47 9.65 113 326705 12996 64158918
Duodenal stenosis 13.42 9.65 17 326801 671 64171243
Brain stem infarction 13.42 9.65 29 326789 1794 64170120
Food allergy 13.40 9.65 12 326806 7839 64164075
Peroneal nerve palsy 13.39 9.65 58 326760 5263 64166651
Cryoglobulinaemia 13.38 9.65 17 326801 673 64171241
Peripheral circulatory failure 13.36 9.65 17 326801 674 64171240
Splenic neoplasm malignancy unspecified 13.36 9.65 6 326812 43 64171871
Cerebral salt-wasting syndrome 13.35 9.65 8 326810 110 64171804
Bone abscess 13.33 9.65 14 326804 450 64171464
Non-cirrhotic portal hypertension 13.33 9.65 13 326805 382 64171532
Myelitis transverse 13.32 9.65 27 326791 1596 64170318
Gastric pneumatosis 13.31 9.65 5 326813 21 64171893
Scopulariopsis infection 13.29 9.65 8 326810 111 64171803
Acute myocardial infarction 13.27 9.65 261 326557 69457 64102457
Mechanical ileus 13.27 9.65 16 326802 600 64171314
Liver function test increased 13.27 9.65 97 326721 30873 64141041
Capnocytophaga infection 13.27 9.65 7 326811 74 64171840
Haptoglobin decreased 13.24 9.65 23 326795 1209 64170705
Gastroenteritis clostridial 13.21 9.65 18 326800 764 64171150
Epiphyses delayed fusion 13.15 9.65 4 326814 7 64171907
Pneumonia mycoplasmal 13.15 9.65 24 326794 1312 64170602
Aspergillus test 13.13 9.65 5 326813 22 64171892
Airway peak pressure increased 13.11 9.65 12 326806 325 64171589
Fungal abscess central nervous system 13.10 9.65 8 326810 114 64171800
Mood swings 13.07 9.65 45 326773 17423 64154491
Cerebral venous sinus thrombosis 13.07 9.65 29 326789 1826 64170088
Coeliac disease 13.05 9.65 11 326807 7401 64164513
Cerebral fungal infection 13.05 9.65 12 326806 327 64171587
Breast pain 13.03 9.65 10 326808 7051 64164863
Epididymitis 13.02 9.65 28 326790 1726 64170188
Tibia fracture 12.94 9.65 53 326765 4692 64167222
Femur fracture 12.93 9.65 244 326574 33891 64138023
Oligohydramnios 12.91 9.65 40 326778 3084 64168830
Haematocolpos 12.91 9.65 6 326812 47 64171867
Trichodysplasia spinulosa 12.89 9.65 17 326801 699 64171215
Immune-mediated enterocolitis 12.88 9.65 36 326782 2620 64169294
Enthesopathy 12.87 9.65 18 326800 9620 64162294
Blood beta-D-glucan abnormal 12.87 9.65 3 326815 0 64171914
Malignant urinary tract neoplasm 12.87 9.65 3 326815 0 64171914
Tuberculous tenosynovitis 12.87 9.65 3 326815 0 64171914
Malignant glaucoma 12.87 9.65 3 326815 0 64171914
Hookworm infection 12.87 9.65 3 326815 0 64171914
Anorectal infection bacterial 12.87 9.65 3 326815 0 64171914
Splint application 12.87 9.65 3 326815 0 64171914
Bezold abscess 12.87 9.65 3 326815 0 64171914
Locked-in syndrome 12.86 9.65 16 326802 620 64171294
Rectal haemorrhage 12.83 9.65 228 326590 61589 64110325
Vitamin D decreased 12.82 9.65 12 326806 7675 64164239
Infected lymphocele 12.82 9.65 10 326808 216 64171698
Gardner-Diamond syndrome 12.81 9.65 4 326814 8 64171906
Drug interaction 12.80 9.65 2055 324763 360028 63811886
Angiosarcoma metastatic 12.80 9.65 6 326812 48 64171866
Restrictive allograft syndrome 12.78 9.65 5 326813 24 64171890
Pseudohypoaldosteronism 12.78 9.65 5 326813 24 64171890
Juvenile idiopathic arthritis 12.77 9.65 46 326772 3833 64168081
Red cell distribution width increased 12.77 9.65 27 326791 12282 64159632
Deafness neurosensory 12.76 9.65 65 326753 6309 64165605
Cholecystitis chronic 12.75 9.65 17 326801 9270 64162644
Threatened labour 12.71 9.65 15 326803 550 64171364
Foot deformity 12.70 9.65 42 326776 16462 64155452
Erosive duodenitis 12.70 9.65 27 326791 1651 64170263
Spindle cell sarcoma 12.70 9.65 10 326808 219 64171695
Brown-Sequard syndrome 12.70 9.65 6 326812 49 64171865
Immune-mediated myositis 12.70 9.65 36 326782 2642 64169272
Bronchiolitis 12.69 9.65 44 326774 3597 64168317
Therapy non-responder 12.68 9.65 430 326388 65469 64106445
Gestational hypertension 12.67 9.65 27 326791 1654 64170260
Cryptosporidiosis infection 12.64 9.65 16 326802 631 64171283
Application site erythema 12.63 9.65 4 326814 4685 64167229
Acne 12.63 9.65 67 326751 23014 64148900
Amoebic dysentery 12.62 9.65 5 326813 25 64171889
Corneal oedema 12.61 9.65 33 326785 2310 64169604
Cardiac autonomic neuropathy 12.59 9.65 6 326812 50 64171864
Encephalitis Japanese B 12.59 9.65 6 326812 50 64171864
Ulna fracture 12.59 9.65 20 326798 976 64170938
Injection site discomfort 12.58 9.65 3 326815 4238 64167676
Acute on chronic liver failure 12.58 9.65 11 326807 280 64171634
Rheumatoid factor 12.58 9.65 8 326810 123 64171791
Coronary artery aneurysm 12.58 9.65 8 326810 123 64171791
Angioimmunoblastic T-cell lymphoma 12.58 9.65 13 326805 410 64171504
Tumour invasion 12.57 9.65 12 326806 343 64171571
Hysterectomy 12.57 9.65 5 326813 5080 64166834
Myasthenia gravis 12.55 9.65 60 326758 5678 64166236
Movement disorder 12.53 9.65 63 326755 21937 64149977
Bedridden 12.52 9.65 91 326727 10018 64161896
Temperature intolerance 12.51 9.65 14 326804 8241 64163673
Interleukin level increased 12.50 9.65 13 326805 413 64171501
Gastric cancer recurrent 12.49 9.65 4 326814 9 64171905
Leukoerythroblastic anaemia 12.49 9.65 4 326814 9 64171905
Conjunctival deposit 12.49 9.65 4 326814 9 64171905
Acute phase reaction 12.48 9.65 11 326807 283 64171631
Reticulocytosis 12.47 9.65 14 326804 486 64171428
Sinus headache 12.44 9.65 3 326815 4204 64167710
Ovarian cyst 12.43 9.65 23 326795 10995 64160919
Ureteral necrosis 12.43 9.65 7 326811 85 64171829
Optic atrophy 12.43 9.65 27 326791 1676 64170238
Oral administration complication 12.36 9.65 8 326810 127 64171787
Polyarthritis 12.35 9.65 88 326730 9627 64162287
Meningitis fungal 12.34 9.65 9 326809 175 64171739
Pancreatic duct stenosis 12.32 9.65 10 326808 229 64171685
Toxic cardiomyopathy 12.32 9.65 12 326806 352 64171562
B-lymphocyte abnormalities 12.31 9.65 5 326813 27 64171887
Malignant respiratory tract neoplasm 12.31 9.65 5 326813 27 64171887
Pneumonia adenoviral 12.29 9.65 9 326809 176 64171738
Urethritis 12.28 9.65 14 326804 494 64171420
H1N1 influenza 12.28 9.65 32 326786 2234 64169680
Thinking abnormal 12.28 9.65 25 326793 11531 64160383
Hemianopia homonymous 12.25 9.65 22 326796 1187 64170727
Metastatic carcinoma of the bladder 12.25 9.65 9 326809 177 64171737
Gas gangrene 12.25 9.65 10 326808 231 64171683
Pulmonary vasculitis 12.25 9.65 10 326808 231 64171683
Abnormal dreams 12.24 9.65 21 326797 10335 64161579
Onychoclasis 12.23 9.65 4 326814 4588 64167326
Diffuse large B-cell lymphoma stage III 12.22 9.65 7 326811 88 64171826
Macrophage activation 12.20 9.65 4 326814 10 64171904
Thyroid stimulating hormone deficiency 12.20 9.65 4 326814 10 64171904
Oedema due to cardiac disease 12.20 9.65 6 326812 54 64171860
Iris transillumination defect 12.20 9.65 8 326810 130 64171784
Frustration tolerance decreased 12.19 9.65 8 326810 6117 64165797
Serositis 12.16 9.65 17 326801 739 64171175
Infective scleritis 12.16 9.65 5 326813 28 64171886
Anal infection 12.15 9.65 7 326811 89 64171825
Shunt infection 12.14 9.65 8 326810 131 64171783
Haematotoxicity 12.12 9.65 109 326709 12787 64159127
Cholelithiasis 12.12 9.65 160 326658 45346 64126568
Cholecystitis infective 12.10 9.65 35 326783 2598 64169316
Sputum retention 12.10 9.65 19 326799 918 64170996
Hemianopia heteronymous 12.09 9.65 7 326811 90 64171824
Body temperature increased 12.07 9.65 123 326695 36543 64135371
Orchitis 12.04 9.65 21 326797 1107 64170807
Spleen tuberculosis 12.01 9.65 5 326813 29 64171885
Pneumonia pseudomonal 12.00 9.65 53 326765 4850 64167064
Vitritis 11.99 9.65 25 326793 1508 64170406
Acute biphenotypic leukaemia 11.99 9.65 8 326810 134 64171780
Incorrect dose administered by device 11.96 9.65 3 326815 4094 64167820
Subdural haematoma 11.96 9.65 88 326730 27966 64143948
Corneal perforation 11.94 9.65 16 326802 668 64171246
Colon dysplasia 11.94 9.65 8 326810 135 64171779
Device failure 11.93 9.65 7 326811 5685 64166229
Oesophageal tuberculosis 11.93 9.65 4 326814 11 64171903
Anterior chamber pigmentation 11.93 9.65 4 326814 11 64171903
Beta-N-acetyl-D-glucosaminidase increased 11.92 9.65 6 326812 57 64171857
Peritonitis viral 11.92 9.65 6 326812 57 64171857
Vein disorder 11.91 9.65 3 326815 4084 64167830
Histology abnormal 11.89 9.65 11 326807 302 64171612
Putamen haemorrhage 11.89 9.65 13 326805 438 64171476
Cardiovascular disorder 11.88 9.65 128 326690 15753 64156161
Peptic ulcer perforation 11.88 9.65 12 326806 368 64171546
Muscle tightness 11.85 9.65 24 326794 11091 64160823
Moraxella infection 11.85 9.65 14 326804 514 64171400
Renal artery thrombosis 11.84 9.65 13 326805 440 64171474
Mesenteric vascular insufficiency 11.84 9.65 8 326810 137 64171777
Rhegmatogenous retinal detachment 11.84 9.65 8 326810 137 64171777
Genital neoplasm malignant female 11.83 9.65 6 326812 58 64171856
Metastatic squamous cell carcinoma 11.82 9.65 13 326805 441 64171473
Arthropod bite 11.80 9.65 10 326808 6711 64165203
Blood potassium increased 11.80 9.65 80 326738 25900 64146014
Sweat gland disorder 11.79 9.65 9 326809 188 64171726
Hypertension 11.79 9.65 1142 325676 258119 63913795
Secretion discharge 11.79 9.65 27 326791 11937 64159977
Infective exacerbation of chronic obstructive airways disease 11.78 9.65 33 326785 2405 64169509
Ocular lymphoma 11.76 9.65 7 326811 95 64171819
Peritonsillar abscess 11.75 9.65 17 326801 763 64171151
Keratopathy 11.75 9.65 17 326801 763 64171151
Cystitis 11.75 9.65 149 326669 42526 64129388
Monocyte percentage decreased 11.72 9.65 10 326808 246 64171668
Catheterisation cardiac 11.71 9.65 5 326813 4868 64167046
Tonic convulsion 11.71 9.65 28 326790 1853 64170061
Urine abnormality 11.69 9.65 12 326806 7350 64164564
Argentine haemorrhagic fever 11.68 9.65 4 326814 12 64171902
Abdominal wall haematoma 11.67 9.65 48 326770 4257 64167657
HELLP syndrome 11.67 9.65 16 326802 683 64171231
Meningococcal sepsis 11.66 9.65 6 326812 60 64171854
Paranoia 11.66 9.65 43 326775 16309 64155605
Blood loss anaemia 11.65 9.65 34 326784 13858 64158056
Leukaemia cutis 11.64 9.65 8 326810 141 64171773
Gastrointestinal oedema 11.63 9.65 32 326786 2308 64169606
Alcohol abuse 11.62 9.65 5 326813 4847 64167067
Myoclonus 11.58 9.65 77 326741 25041 64146873
Diabetic neuropathy 11.58 9.65 7 326811 5594 64166320
Pregnancy on contraceptive 11.57 9.65 17 326801 774 64171140
Menstruation irregular 11.57 9.65 4 326814 4431 64167483
Disorientation 11.56 9.65 206 326612 55622 64116292
Lipohypertrophy 11.56 9.65 17 326801 775 64171139
Chronic hepatitis C 11.53 9.65 14 326804 529 64171385
Blood potassium decreased 11.52 9.65 140 326678 40259 64131655
Granuloma skin 11.51 9.65 61 326757 6013 64165901
No adverse event 11.51 9.65 91 326727 28470 64143444
Amniotic fluid volume increased 11.50 9.65 8 326810 144 64171770
Anal incontinence 11.47 9.65 39 326779 15157 64156757
Oesophageal squamous cell carcinoma 11.47 9.65 13 326805 456 64171458
Abortion missed 11.46 9.65 21 326797 1151 64170763
Demyelinating polyneuropathy 11.46 9.65 24 326794 1452 64170462
Fasciitis 11.46 9.65 16 326802 695 64171219
PO2 decreased 11.46 9.65 35 326783 2678 64169236
Paratracheal lymphadenopathy 11.45 9.65 8 326810 145 64171769
Bronchopulmonary disease 11.44 9.65 4 326814 13 64171901
Hepatic vein stenosis 11.41 9.65 6 326812 63 64171851
Aortic rupture 11.40 9.65 9 326809 198 64171716
Fear of injection 11.40 9.65 8 326810 5904 64166010
Brain oedema 11.39 9.65 166 326652 21909 64150005
Leiomyoma 11.39 9.65 11 326807 319 64171595
Tinea versicolour 11.39 9.65 11 326807 319 64171595
Fulminant type 1 diabetes mellitus 11.39 9.65 20 326798 1060 64170854
Liver transplant 11.39 9.65 46 326772 4046 64167868
Venous thrombosis limb 11.38 9.65 44 326774 3793 64168121
Pulmonary embolism 11.37 9.65 875 325943 145481 64026433
Nerve conduction studies abnormal 11.35 9.65 8 326810 147 64171767
Retinitis viral 11.33 9.65 7 326811 102 64171812
Bradypnoea 11.31 9.65 6 326812 5153 64166761
High density lipoprotein decreased 11.30 9.65 3 326815 3943 64167971
Type 2 lepra reaction 11.28 9.65 9 326809 201 64171713
Acute lymphocytic leukaemia 11.28 9.65 48 326770 4323 64167591
Brucellosis 11.27 9.65 7 326811 103 64171811
Renal tubular acidosis 11.27 9.65 37 326781 2942 64168972
Orthostatic intolerance 11.26 9.65 25 326793 1575 64170339
Pre-existing condition improved 11.26 9.65 5 326813 4757 64167157
Mucocutaneous ulceration 11.25 9.65 11 326807 324 64171590
Mycobacterial peritonitis 11.24 9.65 6 326812 65 64171849
Bradykinesia 11.23 9.65 10 326808 6550 64165364
Blindness cortical 11.22 9.65 17 326801 796 64171118
Drug therapeutic incompatibility 11.22 9.65 8 326810 150 64171764
Basal ganglion degeneration 11.17 9.65 12 326806 396 64171518
Product administration error 11.17 9.65 88 326730 27555 64144359
Congenital coronary artery malformation 11.17 9.65 6 326812 66 64171848
Nocturia 11.16 9.65 25 326793 11140 64160774
Antipsychotic drug level increased 11.14 9.65 6 326812 5109 64166805
Cerebral cyst 11.12 9.65 11 326807 329 64171585
Aortitis 11.11 9.65 20 326798 1081 64170833
Mitochondrial myopathy acquired 11.11 9.65 5 326813 36 64171878
Anaemia 11.08 9.65 2128 324690 376552 63795362
T-lymphocyte count decreased 11.07 9.65 13 326805 474 64171440
Optic neuropathy 11.04 9.65 37 326781 2974 64168940
Haemorrhagic stroke 11.03 9.65 21 326797 9930 64161984
Pericarditis constrictive 11.03 9.65 14 326804 554 64171360
Human herpes virus 6 serology positive 11.02 9.65 9 326809 208 64171706
Thrombocytosis 11.02 9.65 68 326750 7088 64164826
Peptostreptococcus infection 11.01 9.65 6 326812 68 64171846
Pulmonary fistula 11.01 9.65 6 326812 68 64171846
Oesophageal squamous cell carcinoma stage IV 11.00 9.65 4 326814 15 64171899
Bacterial endophthalmitis 11.00 9.65 5 326813 37 64171877
CD4/CD8 ratio decreased 11.00 9.65 5 326813 37 64171877
Biliary anastomosis complication 10.99 9.65 8 326810 155 64171759
Hepatitis C antibody positive 10.98 9.65 9 326809 209 64171705
Concomitant disease progression 10.96 9.65 39 326779 3230 64168684
Diverticulum intestinal haemorrhagic 10.96 9.65 39 326779 3230 64168684
Metastases to lung 10.95 9.65 122 326696 15142 64156772
Attention-seeking behaviour 10.93 9.65 7 326811 109 64171805
Graft complication 10.93 9.65 15 326803 641 64171273
Immunoglobulins decreased 10.91 9.65 22 326796 1296 64170618
Pharyngeal ulceration 10.89 9.65 17 326801 817 64171097
Pericoronitis 10.88 9.65 5 326813 38 64171876
Bone hyperpigmentation 10.88 9.65 5 326813 38 64171876
Appetite disorder 10.88 9.65 10 326808 6451 64165463
B-cell lymphoma refractory 10.87 9.65 7 326811 110 64171804
Dermatitis contact 10.87 9.65 18 326800 8982 64162932
Euglycaemic diabetic ketoacidosis 10.86 9.65 7 326811 5403 64166511
Red blood cell count decreased 10.84 9.65 176 326642 48210 64123704
Heart rate abnormal 10.83 9.65 6 326812 5029 64166885
Disease progression 10.83 9.65 846 325972 140834 64031080
Drug level changed 10.81 9.65 13 326805 486 64171428
Precursor T-lymphoblastic lymphoma/leukaemia stage I 10.81 9.65 3 326815 3 64171911
Penile abscess 10.81 9.65 3 326815 3 64171911
Leukaemic infiltration hepatic 10.81 9.65 3 326815 3 64171911
Eosinophilic otitis media 10.81 9.65 3 326815 3 64171911
Endocrine pancreatic disorder 10.81 9.65 3 326815 3 64171911
Aortic injury 10.81 9.65 3 326815 3 64171911
Brachyspira infection 10.81 9.65 3 326815 3 64171911
Pearly penile papules 10.81 9.65 3 326815 3 64171911
Mediastinal cyst 10.81 9.65 3 326815 3 64171911
Encephalitis post varicella 10.81 9.65 3 326815 3 64171911
Germ cell cancer metastatic 10.81 9.65 3 326815 3 64171911
Dermatopathic lymphadenopathy 10.81 9.65 3 326815 3 64171911
Submaxillary gland enlargement 10.81 9.65 3 326815 3 64171911
Mean platelet volume 10.81 9.65 3 326815 3 64171911
Thought broadcasting 10.81 9.65 3 326815 3 64171911
Raoultella ornithinolytica infection 10.80 9.65 4 326814 16 64171898
Tachypnoea 10.79 9.65 192 326626 26379 64145535
Enterocolitis haemorrhagic 10.77 9.65 28 326790 1952 64169962
Blood pressure inadequately controlled 10.76 9.65 7 326811 5377 64166537
Rheumatic disorder 10.76 9.65 24 326794 1517 64170397
Blindness 10.75 9.65 164 326654 21855 64150059
Neuralgia 10.75 9.65 83 326735 26101 64145813
Prescribed underdose 10.74 9.65 139 326679 17876 64154038
Inflammatory myofibroblastic tumour 10.73 9.65 8 326810 161 64171753
Extra dose administered 10.73 9.65 11 326807 6739 64165175
Gout 10.72 9.65 64 326754 21349 64150565
Malignant fibrous histiocytoma 10.72 9.65 6 326812 72 64171842
Treatment failure 10.72 9.65 483 326335 116333 64055581
Nasal septum disorder 10.71 9.65 7 326811 113 64171801
Metabolic encephalopathy 10.71 9.65 15 326803 8010 64163904
Pancreatitis haemorrhagic 10.70 9.65 14 326804 571 64171343
Remission not achieved 10.69 9.65 11 326807 345 64171569
Therapeutic response unexpected 10.67 9.65 47 326771 16954 64154960
Joint range of motion decreased 10.67 9.65 56 326762 19287 64152627
Burkholderia pseudomallei infection 10.67 9.65 5 326813 40 64171874
Human herpes virus 8 test positive 10.67 9.65 5 326813 40 64171874
Bacteriuria 10.67 9.65 18 326800 924 64170990
Angiodermatitis 10.64 9.65 6 326812 73 64171841
Feeding disorder 10.64 9.65 32 326786 12917 64158997
Palmar-plantar erythrodysaesthesia syndrome 10.63 9.65 94 326724 28725 64143189
Microscopic polyangiitis 10.62 9.65 10 326808 281 64171633
Post-traumatic stress disorder 10.62 9.65 4 326814 4201 64167713
Skin oedema 10.62 9.65 23 326795 1425 64170489
Zika virus infection 10.61 9.65 4 326814 17 64171897
Pneumonia chlamydial 10.61 9.65 7 326811 115 64171799
PCO2 increased 10.57 9.65 25 326793 1642 64170272
Influenza B virus test positive 10.56 9.65 11 326807 350 64171564
Post streptococcal glomerulonephritis 10.56 9.65 5 326813 41 64171873
Acute febrile neutrophilic dermatosis 10.56 9.65 39 326779 3290 64168624
Skin tightness 10.54 9.65 6 326812 4955 64166959
Leukaemia recurrent 10.52 9.65 33 326785 2561 64169353
Infective myositis 10.50 9.65 6 326812 75 64171839
Sluggishness 10.50 9.65 8 326810 5662 64166252
Retroperitoneal lymphadenopathy 10.50 9.65 18 326800 936 64170978
Muscle twitching 10.48 9.65 55 326763 18943 64152971
Necrotising herpetic retinopathy 10.45 9.65 7 326811 118 64171796
Chronic graft versus host disease in intestine 10.44 9.65 10 326808 287 64171627
Pelvic pain 10.44 9.65 25 326793 10885 64161029
Skin atrophy 10.44 9.65 51 326767 4869 64167045
Biopsy bone abnormal 10.43 9.65 4 326814 18 64171896
Corneal epithelium defect 10.43 9.65 15 326803 670 64171244
VIth nerve paralysis 10.42 9.65 23 326795 1443 64170471
Abscess limb 10.42 9.65 60 326758 6101 64165813
Hepatitis B surface antigen positive 10.40 9.65 8 326810 169 64171745
Expired product administered 10.40 9.65 9 326809 5978 64165936
Normochromic anaemia 10.38 9.65 12 326806 430 64171484
Mental impairment 10.37 9.65 45 326773 16298 64155616
Familial mediterranean fever 10.37 9.65 6 326812 77 64171837
Thyroid gland abscess 10.37 9.65 6 326812 77 64171837
Haemorrhoids 10.37 9.65 75 326743 23926 64147988
Typhoid fever 10.36 9.65 5 326813 43 64171871
Acute disseminated encephalomyelitis 10.36 9.65 10 326808 290 64171624
Blood lactate dehydrogenase decreased 10.36 9.65 10 326808 290 64171624
Disorder of orbit 10.35 9.65 7 326811 120 64171794
Burkitt's lymphoma 10.35 9.65 7 326811 120 64171794
Plasminogen decreased 10.35 9.65 3 326815 4 64171910
HIV associated nephropathy 10.33 9.65 10 326808 291 64171623
Arteriosclerosis coronary artery 10.32 9.65 42 326776 15487 64156427
Dystrophic calcification 10.30 9.65 7 326811 121 64171793
Pyuria 10.30 9.65 28 326790 2005 64169909
Joint space narrowing 10.30 9.65 9 326809 229 64171685
Joint abscess 10.29 9.65 11 326807 361 64171553
Varicella virus test positive 10.28 9.65 8 326810 172 64171742
Kaposi sarcoma inflammatory cytokine syndrome 10.26 9.65 4 326814 19 64171895
Umbilical cord vascular disorder 10.26 9.65 4 326814 19 64171895
Angioimmunoblastic T-cell lymphoma stage IV 10.26 9.65 4 326814 19 64171895
Odontogenic cyst 10.26 9.65 4 326814 19 64171895
Bacteroides test positive 10.26 9.65 4 326814 19 64171895
Portal vein stenosis 10.26 9.65 4 326814 19 64171895
Subcapsular renal haematoma 10.26 9.65 15 326803 680 64171234
Coordination abnormal 10.24 9.65 40 326778 14924 64156990
Respiratory tract haemorrhage 10.23 9.65 23 326795 1461 64170453
Hypovolaemia 10.22 9.65 42 326776 15444 64156470
Physical deconditioning 10.21 9.65 20 326798 1153 64170761
Laparotomy 10.16 9.65 10 326808 297 64171617
Respiratory rate increased 10.15 9.65 53 326765 18278 64153636
Dyspnoea 10.11 9.65 3375 323443 715299 63456615
Nephropathy 10.11 9.65 75 326743 8311 64163603
Parvovirus B19 test positive 10.11 9.65 7 326811 125 64171789
Porokeratosis 10.10 9.65 9 326809 235 64171679
Malignant neoplasm of orbit 10.10 9.65 4 326814 20 64171894
Silicosis 10.10 9.65 4 326814 20 64171894
Splenic peliosis 10.10 9.65 4 326814 20 64171894
Blood immunoglobulin M decreased 10.09 9.65 18 326800 966 64170948
Blood corticotrophin decreased 10.07 9.65 11 326807 370 64171544
Omental necrosis 10.07 9.65 5 326813 46 64171868
Renal and pancreas transplant rejection 10.07 9.65 5 326813 46 64171868
Microembolism 10.07 9.65 5 326813 46 64171868
Biliary tract disorder 10.07 9.65 22 326796 1371 64170543
Behaviour disorder 10.07 9.65 5 326813 4457 64167457
Febrile infection 10.06 9.65 35 326783 2866 64169048
Abscess drainage 10.01 9.65 13 326805 526 64171388
Otitis media 10.01 9.65 54 326764 5359 64166555
Infective aortitis 9.98 9.65 5 326813 47 64171867
Protein-losing gastroenteropathy 9.98 9.65 13 326805 528 64171386
Dysarthria 9.96 9.65 227 326591 59179 64112735
Prepyloric stenosis 9.95 9.65 3 326815 5 64171909
Pulmonary oedema 9.95 9.65 313 326505 78361 64093553
Facial paralysis 9.94 9.65 143 326675 18823 64153091
Gastrointestinal hypomotility 9.94 9.65 25 326793 1708 64170206
Hypopharyngeal cancer 9.92 9.65 6 326812 84 64171830
Beta 2 microglobulin urine increased 9.92 9.65 7 326811 129 64171785
Renal salt-wasting syndrome 9.91 9.65 12 326806 452 64171462
Prostate cancer metastatic 9.89 9.65 38 326780 3266 64168648
Infective keratitis 9.89 9.65 5 326813 48 64171866
Lipomatosis 9.88 9.65 11 326807 378 64171536
Pollakiuria 9.88 9.65 107 326711 31423 64140491
Gastrointestinal candidiasis 9.87 9.65 10 326808 308 64171606
Retinitis 9.86 9.65 28 326790 2057 64169857
Pharyngitis bacterial 9.85 9.65 9 326809 243 64171671
Long QT syndrome 9.84 9.65 7 326811 5132 64166782
Jejunal perforation 9.84 9.65 10 326808 309 64171605
Scratch 9.84 9.65 11 326807 6478 64165436
Skin bacterial infection 9.81 9.65 11 326807 381 64171533
Serum sickness 9.81 9.65 37 326781 3152 64168762
Liver function test abnormal 9.81 9.65 381 326437 59020 64112894
Anal cancer 9.80 9.65 14 326804 621 64171293
Infective glossitis 9.80 9.65 5 326813 49 64171865
Tonsillar exudate 9.79 9.65 4 326814 22 64171892
Anal ulcer 9.77 9.65 19 326799 1090 64170824
Meningism 9.75 9.65 13 326805 540 64171374
Hypercalcaemia 9.74 9.65 218 326600 31198 64140716
Nail disorder 9.73 9.65 18 326800 8606 64163308
Retinal scar 9.72 9.65 11 326807 385 64171529
Seminoma 9.72 9.65 8 326810 187 64171727
Chest expansion decreased 9.72 9.65 8 326810 187 64171727
Anterograde amnesia 9.72 9.65 14 326804 626 64171288
Neutrophilic dermatosis 9.72 9.65 13 326805 542 64171372
Haemobilia 9.70 9.65 11 326807 386 64171528
Hepatosplenic T-cell lymphoma 9.70 9.65 16 326802 806 64171108
West Nile viral infection 9.70 9.65 17 326801 900 64171014
Inadequate analgesia 9.69 9.65 4 326814 3974 64167940
Hip deformity 9.68 9.65 8 326810 188 64171726
Endocarditis candida 9.68 9.65 6 326812 88 64171826
Live birth 9.68 9.65 93 326725 11111 64160803
Septic embolus 9.67 9.65 25 326793 1737 64170177
Cholecystitis acute 9.67 9.65 94 326724 11266 64160648

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AC54 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC A07EA01 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC C05AA04 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AA03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, weak (group I)
ATC D07BA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, weak, combinations with antiseptics
ATC D07CA03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, weak, combinations with antibiotics
ATC D07XA02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, weak, other combinations
ATC H02AB06 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD02 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R01AD52 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BA04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01BB02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids and mydriatics in combination
ATC S01CA02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S01CB02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA03 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S02CA01 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03BA02 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC S03CA02 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC V03AB05 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:49103 drug metabolites
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Keratitis indication 5888003 DOID:4677
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Extrinsic allergic alveolitis indication 37471005 DOID:841
Allergic bronchopulmonary aspergillosis indication 37981002 DOID:13166
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Fibrosis of lung indication 51615001 DOID:3770
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Ulcerative colitis indication 64766004 DOID:8577
Löffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Polymyalgia rheumatica indication 65323003 DOID:853
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Stevens-Johnson syndrome indication 73442001 DOID:0050426
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Sympathetic uveitis indication 75315001 DOID:12029
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Sjögren's syndrome indication 83901003 DOID:12894
Bursitis indication 84017003 DOID:2965
Dacryocystitis indication 85777005 DOID:9938
Autoimmune disease indication 85828009
Corneal abrasion indication 85848002
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Bacterial conjunctivitis indication 128350005 DOID:9700
Uveitis indication 128473001 DOID:13141
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Ocular rosacea indication 200933006
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Meibomianitis indication 309779001
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Eosinophilic asthma indication 367542003 DOID:9498
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Giant cell arteritis indication 414341000 DOID:13375
Pneumocystosis jiroveci pneumonia indication 415125002 DOID:11339
Synovitis indication 416209007 DOID:2703
Allergic conjunctivitis indication 473460002 DOID:11204
Post traumatic osteoarthritis indication 699262001
Superficial Ocular Infection indication
Severe Ocular Inflammation indication
Synovitis due to Osteoarthritis indication
Transfusion Reaction Urticaria indication
Erythroblastic Anemia indication
Progressive Diffuse Large B-Cell Lymphoma indication
Diagnostic Test for Cushing's Syndrome indication
Systemic Dermatomyositis indication
Post-Op Ocular Inflammation indication
Otitis externa off-label use 3135009
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Pulmonary edema off-label use 19242006 DOID:11396
Shock off-label use 27942005
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Anaphylaxis off-label use 39579001
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Myasthenia gravis off-label use 91637004 DOID:437
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Bell's palsy off-label use 193093009 DOID:12506
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Allergic otitis externa off-label use 405821001
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Otitis Externa Eczema off-label use
Obstructive Bronchiolitis off-label use
Neuroendocrine Prostate Carcinoma off-label use
Metastatic Prostate Carcinoma off-label use
Otitis Externa Seborrhea off-label use
Prevention of Cytarabine-Induced Keratoconjunctivitis off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Prevention of Post-Extubation Laryngeal Edema off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Herpes simplex keratitis contraindication 9389005
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Skin striae contraindication 201066002
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Injury of eye region contraindication 282752000
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Osteopenia contraindication 312894000
Vaccinia keratitis contraindication 397552005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Traumatic rupture of tendon contraindication 415749005
Porphyria contraindication 418470004
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Infectious allergic keratitis Indication
Cats Traumatic keratitis Indication
Cats Conjunctivitis Indication
Cats Otitis externa Indication
Cats Chronic otitis externa Indication
Dogs Itching Indication
Dogs Inflammation commonly associated with most skin disorders Indication
Dogs Adjunctive therapy in various cough conditions Indication
Dogs Acute or chronic bacterial infections Indication

🐶 Veterinary products

ProductApplicantIngredients
Temaril-P Tablets Zoetis Inc. 2
Temaril-P Spansule Capsule No. 1, Temaril-P Spansule Capsule No. 2 Zoetis Inc. 2
Delta Albaplex 3x Tablets, Delta Albaplex Tablets Zoetis Inc. 3
PrednisTab Lloyd Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.18 acidic
pKa2 12.91 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 7.80 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Mineralocorticoid receptor Nuclear hormone receptor Ki 9.54 CHEMBL
Androgen receptor Nuclear hormone receptor Ki 5.60 CHEMBL
Corticosteroid-binding globulin Secreted Ki 7.51 CHEMBL
Interleukin-6 Cytokine IC50 8.38 CHEMBL
G-protein coupled bile acid receptor 1 GPCR IC50 6.60 CHEMBL
Glutamine synthetase Enzyme EC50 7.49 CHEMBL
Disintegrin and metalloproteinase domain-containing protein 17 Unclassified IC50 7.83 CHEMBL
Progesterone receptor Nuclear hormone receptor IC50 5.68 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 5.58 CHEMBL
Glucocorticoid receptor Transcription factor IC50 7.28 CHEMBL
Glucocorticoid receptor Transcription factor EC50 8.47 CHEMBL

External reference:

IDSource
4017988 VUID
N0000146334 NUI
D00472 KEGG_DRUG
4017988 VANDF
C0032950 UMLSCUI
CHEBI:8378 CHEBI
TUA PDB_CHEM_ID
CHEMBL131 ChEMBL_ID
DB00860 DRUGBANK_ID
D011239 MESH_DESCRIPTOR_UI
5755 PUBCHEM_CID
2866 IUPHAR_LIGAND_ID
535 INN_ID
9PHQ9Y1OLM UNII
8638 RXNORM
5347 MMSL
59710 MMSL
d00084 MMSL
002155 NDDF
116601002 SNOMEDCT_US
52388000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PrednisoLONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-5406 SYRUP 15 mg ORAL ANDA 14 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 12634-686 SOLUTION 15 mg ORAL ANDA 11 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 16590-291 SOLUTION 15 mg ORAL ANDA 11 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 21695-365 SOLUTION 15 mg ORAL ANDA 12 sections
MILLIPRED HUMAN PRESCRIPTION DRUG LABEL 1 23594-505 TABLET 5 mg ORAL ANDA 13 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 33261-475 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-0655 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-0655 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50383-042 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50383-042 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 53217-193 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 54868-4748 SYRUP 5 mg ORAL ANDA 10 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 54868-4749 SYRUP 15 mg ORAL ANDA 10 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 58177-910 SYRUP 15 mg ORAL ANDA 10 sections
PREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 61919-291 SOLUTION 15 mg ORAL ANDA 10 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 63187-466 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 66116-603 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 67296-1656 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 68258-8987 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 68788-9096 SOLUTION 15 mg ORAL ANDA 12 sections
CAMBISON HUMAN OTC DRUG LABEL 2 72689-0016 OINTMENT 4 mg TOPICAL unapproved drug other 7 sections
MILLIPRED HUMAN PRESCRIPTION DRUG LABEL 1 73534-505 TABLET 5 mg ORAL ANDA 13 sections