prednisolone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2245 50-24-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisolone
  • prenolone
  • deltahydrocortisone
  • hydroretrocortin
  • hydroretrocortine
  • metacortandralone
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
  • Molecular weight: 360.45
  • Formula: C21H28O5
  • CLOGP: 1.42
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.18
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.38 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 16 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.24 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 82 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.86 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.25 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 21, 1955 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumocystis jirovecii pneumonia 1086.20 9.63 700 181475 14548 46489339
Cytomegalovirus infection 707.14 9.63 578 181597 17566 46486321
Fatigue 565.85 9.63 944 181231 607753 45896134
Interstitial lung disease 488.91 9.63 807 181368 53142 46450745
Completed suicide 457.86 9.63 28 182147 145892 46357995
Product use in unapproved indication 434.06 9.63 1035 181140 89238 46414649
Pain 410.43 9.63 775 181400 476173 46027714
Sepsis 409.64 9.63 1314 180861 134700 46369187
Product dose omission issue 395.51 9.63 87 182088 168433 46335454
Lymphoproliferative disorder 327.85 9.63 175 182000 2517 46501370
Drug hypersensitivity 324.10 9.63 285 181890 243540 46260347
Haemophagocytic lymphohistiocytosis 323.38 9.63 265 181910 8077 46495810
Hepatic function abnormal 315.91 9.63 518 181657 33903 46469984
Bronchopulmonary aspergillosis 292.41 9.63 239 181936 7257 46496630
Pyrexia 273.37 9.63 2306 179869 346496 46157391
Varicella zoster virus infection 264.94 9.63 145 182030 2198 46501689
Epstein-Barr virus infection 257.72 9.63 213 181962 6571 46497316
Injection site pain 256.02 9.63 53 182122 107099 46396788
Anxiety 244.89 9.63 210 181965 181747 46322140
Death 241.74 9.63 601 181574 334947 46168940
Diffuse large B-cell lymphoma 239.37 9.63 193 181982 5745 46498142
Disseminated intravascular coagulation 228.08 9.63 324 181851 18681 46485206
Hepatitis B 227.66 9.63 155 182020 3538 46500349
Nausea 220.57 9.63 1677 180498 685777 45818110
Thrombotic microangiopathy 209.32 9.63 207 181968 8099 46495788
Pancytopenia 204.54 9.63 763 181412 84295 46419592
Post transplant lymphoproliferative disorder 200.87 9.63 146 182029 3710 46500177
Toxicity to various agents 199.69 9.63 324 181851 211442 46292445
Multiple organ dysfunction syndrome 197.63 9.63 544 181631 51166 46452721
Abdominal discomfort 196.68 9.63 180 181995 150985 46352902
Posterior reversible encephalopathy syndrome 191.91 9.63 265 181910 14876 46489011
Atypical femur fracture 183.80 9.63 154 182021 4843 46499044
Pulmonary tuberculosis 180.66 9.63 149 182026 4582 46499305
Asthenia 179.64 9.63 618 181557 310457 46193430
Headache 179.16 9.63 1114 181061 477238 46026649
Sinusitis 177.91 9.63 147 182028 129621 46374266
Pain in extremity 177.14 9.63 475 181700 258205 46245682
Renal impairment 176.17 9.63 664 181511 73708 46430179
Septic shock 170.07 9.63 555 181620 57338 46446549
Pneumatosis intestinalis 166.83 9.63 102 182073 1923 46501964
Osteonecrosis 165.48 9.63 332 181843 25412 46478475
Kidney transplant rejection 162.09 9.63 132 182043 3986 46499901
Progressive multifocal leukoencephalopathy 158.16 9.63 208 181967 11138 46492749
Hepatitis E 157.82 9.63 83 182092 1156 46502731
Epstein-Barr virus associated lymphoproliferative disorder 157.54 9.63 88 182087 1391 46502496
Dizziness 156.96 9.63 739 181436 339675 46164212
Cytomegalovirus viraemia 156.49 9.63 134 182041 4344 46499543
Transplant rejection 156.10 9.63 190 181985 9406 46494481
Liver disorder 155.58 9.63 405 181770 36841 46467046
C-reactive protein increased 153.88 9.63 541 181634 58049 46445838
Hypogammaglobulinaemia 153.00 9.63 144 182031 5294 46498593
Osteonecrosis of jaw 152.95 9.63 383 181792 34019 46469868
Depression 152.23 9.63 269 181906 169835 46334052
Disseminated tuberculosis 152.06 9.63 108 182067 2644 46501243
Drug abuse 150.10 9.63 32 182143 63376 46440511
Aspergillus infection 148.75 9.63 158 182017 6732 46497155
Nephrotic syndrome 147.52 9.63 135 182040 4786 46499101
Nocardiosis 142.37 9.63 85 182090 1532 46502355
Febrile neutropenia 140.59 9.63 735 181440 93892 46409995
Alveolar proteinosis 139.14 9.63 51 182124 271 46503616
Leukopenia 136.04 9.63 578 181597 67765 46436122
Polyomavirus-associated nephropathy 135.57 9.63 80 182095 1410 46502477
Hepatitis B reactivation 134.38 9.63 80 182095 1434 46502453
Cytomegalovirus colitis 134.32 9.63 84 182091 1651 46502236
Overdose 133.10 9.63 121 182054 101858 46402029
Blood lactate dehydrogenase increased 132.50 9.63 265 181910 20235 46483652
Premature delivery 131.67 9.63 276 181899 21793 46482094
Chorioretinopathy 130.95 9.63 62 182113 679 46503208
BK virus infection 130.81 9.63 100 182075 2749 46501138
General physical health deterioration 127.65 9.63 831 181344 114938 46388949
Intentional overdose 127.35 9.63 47 182128 64897 46438990
Muscle spasms 125.93 9.63 178 181997 122935 46380952
Pneumomediastinum 125.58 9.63 71 182104 1150 46502737
Respiratory failure 123.74 9.63 711 181464 94105 46409782
Upper respiratory tract inflammation 123.73 9.63 96 182079 2699 46501188
Organising pneumonia 123.21 9.63 122 182053 4780 46499107
Feeling abnormal 122.84 9.63 186 181989 124874 46379013
Strongyloidiasis 121.84 9.63 62 182113 803 46503084
Weight increased 120.97 9.63 291 181884 164182 46339705
Psoriasis 120.70 9.63 79 182096 78525 46425362
Pneumonia bacterial 118.11 9.63 140 182035 6739 46497148
Drug intolerance 117.22 9.63 249 181926 146800 46357087
Weight decreased 116.13 9.63 427 181748 210422 46293465
Arthritis bacterial 115.87 9.63 127 182048 5609 46498278
Mycobacterium chelonae infection 115.77 9.63 49 182126 402 46503485
Pneumocystis jirovecii infection 115.71 9.63 68 182107 1189 46502698
Pneumonia 115.07 9.63 2084 180091 374236 46129651
Cytomegalovirus test positive 114.39 9.63 92 182083 2728 46501159
Platelet count decreased 113.32 9.63 723 181452 99301 46404586
Bone marrow failure 110.23 9.63 309 181866 29360 46474527
Glossodynia 110.05 9.63 20 182155 44353 46459534
Cushingoid 110.03 9.63 129 182046 6137 46497750
Pleurisy 107.72 9.63 142 182033 7620 46496267
Hypotension 107.58 9.63 504 181671 232085 46271802
Injection site erythema 106.12 9.63 81 182094 74346 46429541
Lupus nephritis 105.69 9.63 80 182095 2166 46501721
Insomnia 105.24 9.63 313 181862 164611 46339276
Hospitalisation 102.45 9.63 60 182115 63325 46440562
Wrong technique in product usage process 102.38 9.63 42 182133 54380 46449507
Alopecia 101.65 9.63 311 181864 162103 46341784
Brain abscess 101.03 9.63 70 182105 1645 46502242
Cerebral infarction 99.54 9.63 256 181919 23110 46480777
Agranulocytosis 98.61 9.63 247 181928 21938 46481949
JC virus infection 98.29 9.63 68 182107 1594 46502293
Staphylococcal sepsis 97.21 9.63 133 182042 7399 46496488
Swelling 96.59 9.63 214 181961 124297 46379590
Fall 96.50 9.63 821 181354 328276 46175611
Tuberculosis 96.19 9.63 156 182019 10109 46493778
Scleroderma renal crisis 95.60 9.63 37 182138 234 46503653
Meningitis cryptococcal 95.41 9.63 59 182116 1136 46502751
Pneumonia cytomegaloviral 94.86 9.63 71 182104 1889 46501998
Peripheral swelling 94.49 9.63 309 181866 157762 46346125
Herpes zoster 93.84 9.63 517 181658 67355 46436532
Disease recurrence 93.21 9.63 216 181959 18255 46485632
Gait disturbance 92.44 9.63 276 181899 144987 46358900
Gamma-glutamyltransferase increased 92.02 9.63 303 181872 31437 46472450
Polyomavirus viraemia 91.99 9.63 40 182135 353 46503534
Contraindicated product administered 91.66 9.63 106 182069 79841 46424046
Migraine 91.45 9.63 83 182092 69943 46433944
Hand deformity 89.23 9.63 14 182161 34560 46469327
Colitis ulcerative 89.08 9.63 207 181968 17525 46486362
Arthropathy 89.06 9.63 120 182055 84580 46419307
Exposure during pregnancy 86.72 9.63 720 181455 107492 46396395
Injection site bruising 86.37 9.63 17 182158 35619 46468268
Escherichia infection 86.28 9.63 153 182022 10664 46493223
Maternal exposure during pregnancy 85.23 9.63 688 181487 101861 46402026
Peritonitis 85.21 9.63 224 181951 20490 46483397
Pemphigus 85.06 9.63 35 182140 45239 46458648
Mucormycosis 85.05 9.63 71 182104 2221 46501666
Diarrhoea 83.89 9.63 1610 180565 557992 45945895
Injection site reaction 83.62 9.63 41 182134 47808 46456079
Joint swelling 83.30 9.63 349 181826 165724 46338163
Immunosuppressant drug level increased 83.07 9.63 82 182093 3200 46500687
Oesophageal candidiasis 83.02 9.63 102 182073 5098 46498789
Liver transplant rejection 82.77 9.63 57 182118 1326 46502561
Infection reactivation 81.04 9.63 46 182129 751 46503136
Gastroenteritis 80.11 9.63 242 181933 23977 46479910
Pneumonia cryptococcal 80.04 9.63 41 182134 539 46503348
Unevaluable event 80.03 9.63 40 182135 46135 46457752
Viraemia 79.89 9.63 50 182125 984 46502903
Enterocolitis 79.73 9.63 109 182066 6059 46497828
Back pain 78.36 9.63 489 181686 209550 46294337
Somnolence 77.83 9.63 330 181845 156191 46347696
Stress 77.53 9.63 53 182122 51498 46452389
Mental status changes 77.34 9.63 26 182149 38062 46465825
Cardiac failure congestive 76.78 9.63 151 182024 91599 46412288
Steroid diabetes 76.48 9.63 41 182134 595 46503292
Angiocentric lymphoma 76.08 9.63 37 182138 432 46503455
Musculoskeletal stiffness 75.52 9.63 169 182006 97824 46406063
Vasculitis 75.49 9.63 166 182009 13545 46490342
Constipation 74.82 9.63 387 181788 173710 46330177
Low birth weight baby 74.77 9.63 99 182076 5335 46498552
Nasopharyngitis 73.93 9.63 329 181846 153669 46350218
Premature baby 73.62 9.63 195 181980 17917 46485970
Complications of transplanted kidney 73.59 9.63 65 182110 2198 46501689
Alanine aminotransferase increased 73.26 9.63 593 181582 87858 46416029
Cerebrovascular accident 73.26 9.63 180 181995 100859 46403028
Product quality issue 72.97 9.63 24 182151 35624 46468263
Atypical mycobacterial infection 72.83 9.63 45 182130 865 46503022
Nasal congestion 70.33 9.63 51 182124 48062 46455825
Arthralgia 70.29 9.63 1001 181174 363602 46140285
Cytomegalovirus enterocolitis 69.99 9.63 37 182138 521 46503366
Pruritus 69.43 9.63 608 181567 241744 46262143
Gestational diabetes 69.40 9.63 111 182064 7108 46496779
Memory impairment 69.38 9.63 122 182053 77215 46426672
Cytomegalovirus enteritis 68.44 9.63 27 182148 181 46503706
Injection site pruritus 68.02 9.63 35 182140 39708 46464179
Adult T-cell lymphoma/leukaemia 67.85 9.63 31 182144 311 46503576
Lymphopenia 67.68 9.63 170 182005 15123 46488764
Herpes simplex 66.63 9.63 109 182066 7114 46496773
Adrenal suppression 66.06 9.63 43 182132 908 46502979
Drug eruption 65.79 9.63 208 181967 21121 46482766
Bronchiectasis 65.76 9.63 125 182050 9191 46494696
Osteoporosis 65.56 9.63 323 181852 40285 46463602
Inappropriate schedule of product administration 65.45 9.63 95 182080 64918 46438969
Neutropenic sepsis 65.37 9.63 147 182028 12177 46491710
Injury 65.23 9.63 46 182129 43981 46459906
Myopathy 64.97 9.63 121 182054 8760 46495127
Lymphoma 64.78 9.63 128 182047 9685 46494202
Therapeutic product effect decreased 64.01 9.63 142 182033 82459 46421428
Therapy cessation 63.91 9.63 13 182162 26616 46477271
Chronic graft versus host disease 63.32 9.63 65 182110 2660 46501227
Acute respiratory distress syndrome 63.29 9.63 209 181966 21713 46482174
Substance-induced psychotic disorder 63.21 9.63 51 182124 1519 46502368
Graft versus host disease 62.93 9.63 101 182074 6487 46497400
Pseudomonas infection 62.88 9.63 126 182049 9632 46494255
Gastric ulcer 62.73 9.63 208 181967 21655 46482232
Injection site swelling 62.61 9.63 40 182135 40287 46463600
Suicidal ideation 62.23 9.63 77 182098 56305 46447582
Electrocardiogram QT prolonged 62.18 9.63 65 182110 51260 46452627
Suicide attempt 61.97 9.63 74 182101 54962 46448925
Balance disorder 61.37 9.63 98 182077 64423 46439464
Aspartate aminotransferase increased 61.09 9.63 520 181655 78180 46425707
Pyelonephritis 61.07 9.63 164 182011 15193 46488694
Adverse drug reaction 61.05 9.63 50 182125 44312 46459575
Heart rate increased 60.93 9.63 125 182050 74666 46429221
Disseminated varicella zoster virus infection 60.86 9.63 37 182138 690 46503197
Gastrooesophageal reflux disease 60.78 9.63 124 182051 74220 46429667
Device dislocation 60.61 9.63 7 182168 21795 46482092
Diabetes mellitus 60.47 9.63 368 181807 49697 46454190
Blood beta-D-glucan increased 60.43 9.63 26 182149 223 46503664
Cryptococcosis 60.35 9.63 39 182136 813 46503074
Listeria sepsis 60.23 9.63 34 182141 549 46503338
Blood pressure increased 59.94 9.63 272 181903 126394 46377493
Immunosuppression 59.71 9.63 106 182069 7394 46496493
Cytomegalovirus infection reactivation 59.66 9.63 48 182127 1424 46502463
Tendon rupture 59.64 9.63 108 182067 7651 46496236
Premature labour 59.07 9.63 134 182041 11165 46492722
Infectious pleural effusion 59.03 9.63 42 182133 1031 46502856
Drug ineffective 58.97 9.63 2110 180065 675728 45828159
Toxic epidermal necrolysis 58.70 9.63 206 181969 22072 46481815
Multiple sclerosis relapse 58.57 9.63 47 182128 42078 46461809
Necrotising fasciitis 58.13 9.63 61 182114 2562 46501325
Listeriosis 58.04 9.63 43 182132 1126 46502761
Lower respiratory tract infection 57.96 9.63 391 181784 54698 46449189
Confusional state 56.66 9.63 378 181797 159514 46344373
Spinal compression fracture 56.65 9.63 143 182032 12760 46491127
Encephalitis 56.40 9.63 103 182072 7345 46496542
Malignant neoplasm of conjunctiva 56.37 9.63 16 182159 29 46503858
Synovitis 56.00 9.63 95 182080 60980 46442907
Mycobacterium avium complex infection 55.88 9.63 60 182115 2588 46501299
Central nervous system lymphoma 55.35 9.63 43 182132 1211 46502676
Contusion 55.06 9.63 167 182008 87320 46416567
Neutropenia 55.02 9.63 824 181351 142380 46361507
Diffuse large B-cell lymphoma recurrent 54.91 9.63 46 182129 1446 46502441
Thrombocytopenia 54.88 9.63 744 181431 125837 46378050
Proteinuria 54.37 9.63 165 182010 16388 46487499
Device issue 54.11 9.63 7 182168 19973 46483914
Rheumatoid factor positive 53.45 9.63 8 182167 20453 46483434
Disseminated cryptococcosis 53.27 9.63 25 182150 268 46503619
Pleural effusion 52.21 9.63 524 181651 82428 46421459
Haemolytic anaemia 51.76 9.63 117 182058 9725 46494162
Tuberculous pleurisy 51.65 9.63 28 182147 416 46503471
Large intestine perforation 51.41 9.63 100 182075 7480 46496407
Off label use 51.29 9.63 1887 180288 377954 46125933
Emotional distress 51.14 9.63 28 182147 30679 46473208
Full blood count decreased 50.96 9.63 12 182163 22199 46481688
Enteritis infectious 50.88 9.63 51 182124 2028 46501859
Bacterial sepsis 50.65 9.63 66 182109 3501 46500386
Bradycardia 50.52 9.63 115 182060 66183 46437704
Subarachnoid haemorrhage 50.42 9.63 125 182050 11028 46492859
Drug withdrawal syndrome 50.11 9.63 22 182153 27362 46476525
Foetal exposure during pregnancy 49.94 9.63 245 181930 30502 46473385
Oral candidiasis 49.59 9.63 166 182009 17366 46486521
Idiopathic pulmonary fibrosis 48.91 9.63 43 182132 1445 46502442
Eosinophilic granulomatosis with polyangiitis 48.58 9.63 47 182128 1789 46502098
Cardiac failure 48.39 9.63 501 181674 79447 46424440
Placenta accreta 48.34 9.63 20 182155 154 46503733
Intentional self-injury 48.19 9.63 17 182158 24149 46479738
Aplasia pure red cell 48.08 9.63 72 182103 4353 46499534
Normal newborn 48.01 9.63 85 182090 5916 46497971
Rhinorrhoea 47.63 9.63 70 182105 47595 46456292
Blood pressure fluctuation 47.54 9.63 30 182145 30418 46473469
Mycobacterial infection 47.40 9.63 44 182131 1589 46502298
Viral vasculitis 47.39 9.63 15 182160 46 46503841
Human T-cell lymphotropic virus type I infection 46.91 9.63 15 182160 48 46503839
Steroid withdrawal syndrome 46.35 9.63 27 182148 464 46503423
Hypoalbuminaemia 46.31 9.63 114 182061 10013 46493874
Foetal growth restriction 46.21 9.63 88 182087 6479 46497408
Meningitis listeria 46.14 9.63 25 182150 371 46503516
Drug resistance 46.10 9.63 161 182014 17207 46486680
Altered state of consciousness 46.06 9.63 197 181978 23151 46480736
Skin ulcer 46.02 9.63 249 181926 32209 46471678
Nervousness 45.94 9.63 27 182148 28448 46475439
Hypoaesthesia 45.70 9.63 274 181901 118595 46385292
Neck pain 45.41 9.63 92 182083 55214 46448673
Foetal methotrexate syndrome 45.36 9.63 15 182160 55 46503832
Tremor 45.28 9.63 265 181910 115374 46388513
Mycobacterium abscessus infection 45.20 9.63 29 182146 597 46503290
Serotonin syndrome 45.04 9.63 19 182156 24201 46479686
Subcutaneous emphysema 44.64 9.63 32 182143 795 46503092
Muscle abscess 44.48 9.63 24 182151 353 46503534
Acute graft versus host disease 44.40 9.63 66 182109 3964 46499923
Fibromyalgia 44.37 9.63 46 182129 36417 46467470
Neuropathy peripheral 44.31 9.63 193 181982 90700 46413187
Lung infiltration 44.27 9.63 138 182037 13905 46489982
Erythema multiforme 44.12 9.63 109 182066 9595 46494292
Klebsiella infection 44.10 9.63 87 182088 6575 46497312
Endocarditis bacterial 44.04 9.63 28 182147 567 46503320
Myelodysplastic syndrome 43.76 9.63 148 182027 15563 46488324
Enterococcal infection 43.57 9.63 89 182086 6898 46496989
Systemic mycosis 43.51 9.63 33 182142 896 46502991
Immunosuppressant drug level decreased 43.42 9.63 33 182142 899 46502988
Hot flush 43.39 9.63 64 182111 43453 46460434
Osteoporotic fracture 43.29 9.63 56 182119 2949 46500938
Hepatic failure 43.16 9.63 250 181925 33166 46470721
Mycobacterium marinum infection 42.96 9.63 17 182158 115 46503772
Influenza like illness 42.95 9.63 101 182074 57469 46446418
Pneumothorax 42.70 9.63 140 182035 14489 46489398
Iron deficiency anaemia 42.68 9.63 156 182019 17050 46486837
Sedation 42.56 9.63 18 182157 22892 46480995
Injection site haemorrhage 42.28 9.63 14 182161 20695 46483192
Crying 41.94 9.63 15 182160 21126 46482761
Loss of consciousness 41.87 9.63 249 181926 107989 46395898
Cerebral haemorrhage 41.82 9.63 220 181955 28151 46475736
Infection in an immunocompromised host 41.61 9.63 25 182150 456 46503431
Dehydration 41.43 9.63 410 181765 159130 46344757
Pyoderma gangrenosum 41.30 9.63 52 182123 2665 46501222
Angiosarcoma 41.16 9.63 20 182155 233 46503654
Fluid retention 40.99 9.63 86 182089 50960 46452927
Burning sensation 40.79 9.63 69 182106 44342 46459545
Incorrect dose administered 40.71 9.63 72 182103 45478 46458409
Escherichia bacteraemia 40.63 9.63 52 182123 2709 46501178
Obliterative bronchiolitis 40.63 9.63 42 182133 1733 46502154
Liver abscess 40.59 9.63 51 182124 2608 46501279
Poisoning 40.16 9.63 4 182171 13990 46489897
Blood glucose increased 40.12 9.63 145 182030 71868 46432019
Endocarditis 40.11 9.63 71 182104 4941 46498946
Vomiting 39.78 9.63 1407 180768 451387 46052500
Adrenal insufficiency 39.57 9.63 127 182048 12997 46490890
Retinal detachment 39.21 9.63 71 182104 5029 46498858
Chronic allograft nephropathy 39.10 9.63 27 182148 631 46503256
Injection site mass 39.01 9.63 6 182169 15034 46488853
Cerebral toxoplasmosis 38.98 9.63 28 182147 698 46503189
Pyelonephritis acute 38.97 9.63 63 182112 4071 46499816
Discomfort 38.86 9.63 77 182098 46593 46457294
Secondary adrenocortical insufficiency 38.61 9.63 30 182145 845 46503042
Respiratory arrest 38.56 9.63 45 182130 33771 46470116
White blood cell count increased 38.53 9.63 300 181875 43919 46459968
Kaposi's sarcoma 38.43 9.63 17 182158 157 46503730
Thymoma 38.26 9.63 14 182161 74 46503813
Blood glucose decreased 38.17 9.63 13 182162 18879 46485008
Bacteraemia 38.12 9.63 132 182043 14047 46489840
Inflammatory marker increased 38.07 9.63 73 182102 5402 46498485
Hypersensitivity 37.50 9.63 390 181785 149931 46353956
Musculoskeletal chest pain 37.39 9.63 12 182163 18094 46485793
Nephritis 37.36 9.63 42 182133 1908 46501979
Hypofibrinogenaemia 37.35 9.63 32 182143 1038 46502849
Anti-cyclic citrullinated peptide antibody positive 37.27 9.63 14 182161 19131 46484756
Lemierre syndrome 37.11 9.63 15 182160 108 46503779
Erysipelas 37.07 9.63 83 182092 6855 46497032
Subcutaneous abscess 37.06 9.63 69 182106 4994 46498893
Cytomegalovirus chorioretinitis 36.94 9.63 37 182138 1470 46502417
COVID-19 36.85 9.63 157 182018 18418 46485469
Cytomegalovirus gastroenteritis 36.57 9.63 17 182158 178 46503709
Antiphospholipid syndrome 36.49 9.63 39 182136 1673 46502214
Unresponsive to stimuli 36.49 9.63 43 182132 32131 46471756
Systemic candida 36.47 9.63 49 182126 2678 46501209
Dyspepsia 36.11 9.63 141 182034 68331 46435556
Neuropsychiatric lupus 36.09 9.63 15 182160 117 46503770
Pancreatitis acute 36.07 9.63 192 181983 24680 46479207
Duodenal ulcer 35.96 9.63 84 182091 7134 46496753
Hyperglycaemia 35.74 9.63 247 181928 34824 46469063
Adrenocortical insufficiency acute 35.63 9.63 34 182141 1272 46502615
Meningitis bacterial 35.52 9.63 33 182142 1193 46502694
Concomitant disease aggravated 35.27 9.63 88 182087 7794 46496093
Amnesia 35.26 9.63 68 182107 41563 46462324
Nephropathy toxic 35.25 9.63 85 182090 7369 46496518
Paraesthesia 35.19 9.63 291 181884 117146 46386741
Blood count abnormal 34.93 9.63 13 182162 17865 46486022
Psoriatic arthropathy 34.83 9.63 55 182120 36324 46467563
Immune thrombocytopenia 34.79 9.63 90 182085 8151 46495736
Scedosporium infection 34.63 9.63 23 182152 503 46503384
Chest pain 34.61 9.63 482 181693 175842 46328045
Central nervous system vasculitis 34.52 9.63 29 182146 915 46502972
Renal transplant failure 34.43 9.63 25 182150 634 46503253
Pneumoperitoneum 34.20 9.63 35 182140 1427 46502460
Sinus disorder 34.16 9.63 11 182164 16552 46487335
Accidental exposure to product 33.99 9.63 20 182155 21061 46482826
Heart rate irregular 33.91 9.63 15 182160 18576 46485311
Seizure 33.73 9.63 312 181863 122742 46381145
Cholangitis 33.34 9.63 63 182112 4611 46499276
Treatment failure 32.98 9.63 220 181955 92867 46411020
Lymph node tuberculosis 32.76 9.63 26 182149 756 46503131
Cardiac disorder 32.67 9.63 77 182098 43781 46460106
Parvovirus B19 infection 32.64 9.63 19 182156 326 46503561
Anaphylactoid reaction 32.63 9.63 53 182122 3438 46500449
Meningitis tuberculous 32.63 9.63 23 182152 556 46503331
Intentional product misuse 32.56 9.63 86 182089 47042 46456845
Adrenal atrophy 32.52 9.63 10 182165 27 46503860
Injection site warmth 32.48 9.63 7 182168 13765 46490122
Ill-defined disorder 32.46 9.63 34 182141 26793 46477094
Glomerulonephritis membranoproliferative 32.36 9.63 15 182160 156 46503731
Heart rate decreased 32.27 9.63 46 182129 31677 46472210
Synostosis 32.14 9.63 11 182164 46 46503841
Lymphocytic infiltration 32.07 9.63 26 182149 780 46503107
Abscess 32.02 9.63 123 182052 13766 46490121
Cystitis haemorrhagic 32.01 9.63 53 182122 3494 46500393
Pulmonary nocardiosis 32 9.63 13 182162 95 46503792
Feeling jittery 31.97 9.63 3 182172 11005 46492882
Central nervous system lupus 31.95 9.63 11 182164 47 46503840
Alveolitis 31.86 9.63 44 182131 2469 46501418
Sleep apnoea syndrome 31.84 9.63 24 182151 22177 46481710
Intraocular pressure increased 31.53 9.63 71 182104 5886 46498001
Intervertebral discitis 31.51 9.63 44 182131 2495 46501392
Synovectomy 31.47 9.63 15 182160 167 46503720
Secondary immunodeficiency 31.40 9.63 28 182147 959 46502928
Ecthyma 31.26 9.63 16 182159 210 46503677
Arterial haemorrhage 31.22 9.63 36 182139 1682 46502205
Enterococcal sepsis 31.20 9.63 32 182143 1308 46502579
Abdominal pain upper 31.14 9.63 390 181785 144915 46358972
Transplant failure 31.13 9.63 31 182144 1223 46502664
Rheumatoid arthritis 31.10 9.63 707 181468 239508 46264379
Primary biliary cholangitis 31.03 9.63 30 182145 1141 46502746
Empyema 31.01 9.63 37 182138 1793 46502094
Therapy partial responder 30.82 9.63 61 182114 4621 46499266
Staphylococcal infection 30.78 9.63 242 181933 35529 46468358
Listeria encephalitis 30.70 9.63 15 182160 177 46503710
Psoas abscess 30.40 9.63 19 182156 373 46503514
Symptom masked 30.30 9.63 22 182153 558 46503329
Restless legs syndrome 30.16 9.63 12 182163 15831 46488056
Pneumonitis 30.05 9.63 202 181973 28218 46475669
Diffuse large B-cell lymphoma refractory 29.98 9.63 27 182148 937 46502950
Cardiac valve vegetation 29.87 9.63 17 182158 279 46503608
Cardio-respiratory arrest 29.86 9.63 126 182049 59743 46444144
Opportunistic infection 29.83 9.63 35 182140 1666 46502221
Femoral neck fracture 29.70 9.63 84 182091 8019 46495868
Retroperitoneal abscess 29.68 9.63 13 182162 117 46503770
Dermatomyositis 29.64 9.63 38 182137 1983 46501904
Focal segmental glomerulosclerosis 29.64 9.63 32 182143 1389 46502498
Rheumatoid vasculitis 29.45 9.63 18 182157 339 46503548
Herpes simplex reactivation 29.32 9.63 18 182157 342 46503545
Throat irritation 29.31 9.63 42 182133 28859 46475028
Osteomyelitis 29.26 9.63 168 182007 22215 46481672
Colon cancer 29.14 9.63 91 182084 9178 46494709
Limb reduction defect 29.09 9.63 18 182157 347 46503540
Dry skin 28.99 9.63 74 182101 40942 46462945
Joint stiffness 28.89 9.63 38 182137 27070 46476817
Thyroiditis subacute 28.86 9.63 16 182159 249 46503638
Blood immunoglobulin G decreased 28.79 9.63 36 182139 1832 46502055
Laboratory test abnormal 28.73 9.63 28 182147 22819 46481068
B-cell lymphoma recurrent 28.71 9.63 19 182156 413 46503474
Gallbladder rupture 28.67 9.63 19 182156 414 46503473
Shock 28.58 9.63 164 182011 21681 46482206
Ascites 28.51 9.63 242 181933 36342 46467545
Lumbar vertebral fracture 28.49 9.63 58 182117 4484 46499403
Tumour lysis syndrome 28.49 9.63 77 182098 7159 46496728
Blood cholesterol increased 28.42 9.63 72 182103 39941 46463946
Injection site urticaria 28.39 9.63 6 182169 11961 46491926
Pulmonary fibrosis 28.38 9.63 154 182021 19938 46483949
Haemorrhage subcutaneous 28.37 9.63 45 182130 2861 46501026
Splenic abscess 28.36 9.63 11 182164 70 46503817
Urosepsis 28.34 9.63 127 182048 15226 46488661
Aortic dissection 28.32 9.63 33 182142 1559 46502328
Type 1 diabetes mellitus 28.32 9.63 45 182130 2865 46501022
Sinus congestion 28.32 9.63 8 182167 13101 46490786
Hyperhidrosis 28.27 9.63 218 181957 89090 46414797
Granulomatosis with polyangiitis 28.21 9.63 35 182140 1767 46502120
Drug interaction 28.06 9.63 1012 181163 202082 46301805
Blood pressure systolic increased 28.05 9.63 43 182132 28744 46475143
Purpura 27.91 9.63 94 182081 9864 46494023
Tachyarrhythmia 27.70 9.63 58 182117 4574 46499313
Gallbladder disorder 27.65 9.63 17 182158 17481 46486406
Splenomegaly 27.64 9.63 92 182083 9596 46494291
Panic attack 27.62 9.63 23 182152 20219 46483668
Emotional disorder 27.60 9.63 7 182168 12317 46491570
Haemolytic uraemic syndrome 27.45 9.63 41 182134 2473 46501414
Neutrophilic panniculitis 27.43 9.63 9 182166 32 46503855
Phaeohyphomycosis 27.43 9.63 15 182160 227 46503660
Epstein Barr virus positive mucocutaneous ulcer 27.43 9.63 15 182160 227 46503660
Cell marker increased 27.37 9.63 17 182158 330 46503557
Microsporidia infection 27.37 9.63 15 182160 228 46503659
Systemic inflammatory response syndrome 27.30 9.63 63 182112 5308 46498579
Abscess bacterial 27.27 9.63 14 182161 185 46503702
Blood creatinine increased 27.15 9.63 434 181741 75969 46427918
Pneumonia fungal 27.14 9.63 54 182121 4106 46499781
Surgery 27.10 9.63 44 182131 28741 46475146
Polyomavirus test positive 27.01 9.63 11 182164 81 46503806
Hyperuricaemia 26.98 9.63 58 182117 4659 46499228
Herpes zoster meningitis 26.85 9.63 10 182165 56 46503831
Melaena 26.78 9.63 193 181982 27579 46476308
B-cell lymphoma refractory 26.78 9.63 11 182164 83 46503804
Muscle spasticity 26.60 9.63 6 182169 11434 46492453
Therapy interrupted 26.46 9.63 5 182170 10786 46493101
Lung abscess 26.46 9.63 30 182145 1376 46502511
Flushing 26.40 9.63 146 182029 64468 46439419
Neutrophilia 26.22 9.63 44 182131 2933 46500954
Sleep disorder 26.21 9.63 94 182081 46701 46457186
Acute graft versus host disease in skin 26.16 9.63 44 182131 2938 46500949
Circulatory collapse 26.13 9.63 159 182016 21465 46482422
Glomerulonephritis membranous 26.12 9.63 20 182155 551 46503336
Epstein-Barr virus infection reactivation 26.10 9.63 15 182160 251 46503636
Pulmonary cavitation 26.09 9.63 22 182153 698 46503189
Rheumatic disorder 26.08 9.63 30 182145 1398 46502489
Blast crisis in myelogenous leukaemia 25.93 9.63 19 182156 489 46503398
Small for dates baby 25.91 9.63 49 182126 3588 46500299
Anal prolapse 25.87 9.63 12 182163 125 46503762
Cytomegalovirus hepatitis 25.78 9.63 16 182159 310 46503577
Anterograde amnesia 25.71 9.63 17 182158 369 46503518
Substance-induced mood disorder 25.68 9.63 7 182168 10 46503877
Graft loss 25.67 9.63 17 182158 370 46503517
Meningoencephalitis herpetic 25.57 9.63 26 182149 1052 46502835
Injection site rash 25.50 9.63 15 182160 15798 46488089
Neuromyelitis optica spectrum disorder 25.37 9.63 23 182152 805 46503082
Infective exacerbation of chronic obstructive airways disease 25.36 9.63 27 182148 1153 46502734
Gait inability 25.27 9.63 63 182112 35140 46468747
Fluid overload 25.18 9.63 42 182133 27143 46476744
DNULL antibody positive 25.08 9.63 16 182159 326 46503561
Juvenile idiopathic arthritis 25.02 9.63 52 182123 4080 46499807
Cutaneous tuberculosis 24.99 9.63 12 182163 136 46503751
Rebound effect 24.95 9.63 41 182134 2686 46501201
Quadrantanopia 24.93 9.63 8 182167 26 46503861
Bronchostenosis 24.87 9.63 16 182159 331 46503556
Talipes 24.76 9.63 29 182146 1378 46502509
Gastrointestinal amyloidosis 24.74 9.63 10 182165 72 46503815
Dyskinesia 24.71 9.63 47 182128 28878 46475009
Uterine haematoma 24.70 9.63 8 182167 27 46503860
Bronchopleural fistula 24.69 9.63 14 182161 228 46503659
Adverse event 24.68 9.63 61 182114 34123 46469764
Peritoneal tuberculosis 24.49 9.63 19 182156 534 46503353
Infective pulmonary exacerbation of cystic fibrosis 24.47 9.63 6 182169 10801 46493086
Plasma cell myeloma 24.47 9.63 90 182085 44388 46459499
Encephalitis viral 24.46 9.63 31 182144 1599 46502288
Gastritis haemorrhagic 24.45 9.63 28 182147 1298 46502589
Complication associated with device 24.40 9.63 15 182160 15426 46488461
Hypersomnia 24.40 9.63 15 182160 15424 46488463
Glomerulonephritis rapidly progressive 24.28 9.63 21 182154 690 46503197
Carpal tunnel syndrome 24.25 9.63 16 182159 15843 46488044
Disseminated trichosporonosis 24.22 9.63 7 182168 14 46503873
Multiple sclerosis 24.19 9.63 37 182138 24754 46479133
Spine malformation 24.17 9.63 14 182161 238 46503649
Small intestinal perforation 24.12 9.63 27 182148 1221 46502666
Gastric cancer 24.09 9.63 42 182133 2887 46501000
Ureterolithiasis 24.09 9.63 32 182143 1730 46502157
Anaplastic large-cell lymphoma 23.93 9.63 11 182164 112 46503775
Autoimmune hepatitis 23.91 9.63 76 182099 7738 46496149
Meningitis 23.86 9.63 65 182110 6071 46497816
Renal artery thrombosis 23.84 9.63 10 182165 80 46503807
Adenovirus infection 23.83 9.63 41 182134 2789 46501098
Urinary incontinence 23.81 9.63 47 182128 28483 46475404
Fungal endocarditis 23.81 9.63 14 182161 245 46503642
Leukoencephalopathy 23.79 9.63 50 182125 3954 46499933
Panniculitis 23.78 9.63 62 182113 5642 46498245
Ear infection 23.77 9.63 33 182142 22980 46480907
Metaphyseal corner fracture 23.65 9.63 8 182167 32 46503855
Infection masked 23.65 9.63 8 182167 32 46503855
Duodenal ulcer repair 23.65 9.63 9 182166 54 46503833
Jaundice 23.65 9.63 193 181982 28652 46475235
Pulmonary alveolar haemorrhage 23.60 9.63 51 182124 4111 46499776
Threatened labour 23.59 9.63 22 182153 799 46503088
Cognitive disorder 23.48 9.63 70 182105 36813 46467074
Bursitis infective staphylococcal 23.46 9.63 8 182167 33 46503854
Tubulointerstitial nephritis 23.41 9.63 117 182058 14671 46489216
Ileus paralytic 23.41 9.63 52 182123 4271 46499616
Pancreatic steatosis 23.40 9.63 24 182151 981 46502906
Aortic valve stenosis 23.40 9.63 43 182132 3081 46500806
Bacterial infection 23.39 9.63 125 182050 16091 46487796
Subileus 23.34 9.63 42 182133 2961 46500926
Hypocomplementaemia 23.21 9.63 12 182163 161 46503726
Lymphocele 23.21 9.63 22 182153 816 46503071
Microscopic polyangiitis 23.19 9.63 11 182164 121 46503766
Reversible cerebral vasoconstriction syndrome 23.19 9.63 31 182144 1686 46502201
Polyarthritis 23.18 9.63 67 182108 6475 46497412
Macular pseudohole 23.17 9.63 6 182169 6 46503881
Coombs positive haemolytic anaemia 23.17 9.63 16 182159 374 46503513
Bronchiolitis 23.16 9.63 36 182139 2249 46501638
Influenza 22.91 9.63 230 181945 89040 46414847
Head injury 22.87 9.63 38 182137 24598 46479289
Graft versus host disease in gastrointestinal tract 22.87 9.63 38 182137 2512 46501375
Malaise 22.84 9.63 1058 181117 330174 46173713
Mediastinitis 22.81 9.63 13 182162 214 46503673
Acute abdomen 22.78 9.63 29 182146 1503 46502384
Dry eye 22.77 9.63 53 182122 30269 46473618
Viral haemorrhagic cystitis 22.77 9.63 19 182156 594 46503293
IIIrd nerve paralysis 22.72 9.63 20 182155 673 46503214
Hernia 22.72 9.63 5 182170 9690 46494197
Respiratory tract infection 22.69 9.63 197 181978 29775 46474112
Henoch-Schonlein purpura 22.68 9.63 24 182151 1018 46502869
Infective spondylitis 22.65 9.63 11 182164 128 46503759
Chest X-ray abnormal 22.61 9.63 47 182128 3688 46500199
Drug-induced liver injury 22.59 9.63 173 182002 25195 46478692
Limb hypoplasia congenital 22.57 9.63 12 182163 171 46503716
Dry mouth 22.50 9.63 124 182051 54802 46449085
Blood alkaline phosphatase increased 22.45 9.63 245 181930 39364 46464523
Corynebacterium infection 22.37 9.63 16 182159 396 46503491
Oligohydramnios 22.37 9.63 59 182116 5406 46498481
Wound infection pseudomonas 22.36 9.63 28 182147 1427 46502460
Cardiac arrest 22.34 9.63 235 181940 90164 46413723
Underdose 22.33 9.63 26 182149 19532 46484355
Irritable bowel syndrome 22.24 9.63 19 182156 16496 46487391
Infective tenosynovitis 22.24 9.63 13 182162 225 46503662
Pain in jaw 22.21 9.63 76 182099 38296 46465591
Sneezing 22.13 9.63 11 182164 12730 46491157
External auditory canal atresia 22.13 9.63 9 182166 66 46503821
Atypical haemolytic uraemic syndrome 22.12 9.63 17 182158 471 46503416
Eye infection fungal 22.09 9.63 10 182165 98 46503789
Neisseria infection 22.06 9.63 8 182167 41 46503846
Uveitis 21.99 9.63 79 182096 8562 46495325
Bedridden 21.84 9.63 82 182093 9077 46494810
Pneumonia pneumococcal 21.81 9.63 31 182144 1787 46502100
Meningoencephalitis bacterial 21.79 9.63 9 182166 69 46503818
Intussusception 21.78 9.63 17 182158 482 46503405
Left ventricular hypertrophy 21.78 9.63 55 182120 4908 46498979
Renal abscess 21.77 9.63 19 182156 632 46503255
Hepatosplenomegaly 21.73 9.63 36 182139 2374 46501513
Nuchal rigidity 21.70 9.63 18 182157 558 46503329
Ligament sprain 21.67 9.63 7 182168 10512 46493375
Myositis 21.61 9.63 74 182101 7830 46496057
Skin mass 21.61 9.63 57 182118 5223 46498664
Dysgeusia 21.58 9.63 83 182092 40408 46463479
Nephrolithiasis 21.57 9.63 62 182113 32989 46470898
Cryoglobulinaemia 21.56 9.63 15 182160 355 46503532
Skin erosion 21.51 9.63 35 182140 2274 46501613
Oesophageal perforation 21.50 9.63 13 182162 240 46503647
C-reactive protein abnormal 21.48 9.63 31 182144 21239 46482648
Trichophytosis 21.45 9.63 8 182167 45 46503842
Diverticular perforation 21.45 9.63 43 182132 3288 46500599
Aplastic anaemia 21.37 9.63 69 182106 7084 46496803
Lupus enteritis 21.35 9.63 9 182166 73 46503814
Varicella zoster pneumonia 21.31 9.63 7 182168 25 46503862
Pre-eclampsia 21.12 9.63 74 182101 7920 46495967
Device malfunction 21.12 9.63 13 182162 13361 46490526
Infected skin ulcer 21.10 9.63 34 182141 2191 46501696
Cutaneous T-cell lymphoma stage IV 21.10 9.63 6 182169 11 46503876
Anhedonia 21.07 9.63 7 182168 10328 46493559
Escherichia urinary tract infection 21.06 9.63 88 182087 10235 46493652
Hepatitis 20.98 9.63 205 181970 32010 46471877
Intestinal perforation 20.97 9.63 91 182084 10760 46493127
Myelosuppression 20.96 9.63 72 182103 7631 46496256
Anogenital warts 20.91 9.63 15 182160 373 46503514
Musculoskeletal pain 20.89 9.63 174 182001 69954 46433933
Abscess rupture 20.87 9.63 12 182163 201 46503686
Condition aggravated 20.82 9.63 1162 181013 243890 46259997
Vitamin D decreased 20.82 9.63 3 182172 7890 46495997
Growth retardation 20.79 9.63 22 182153 933 46502954
Pulmonary embolism 20.78 9.63 563 181612 108022 46395865
Encapsulating peritoneal sclerosis 20.78 9.63 15 182160 377 46503510
Intervertebral disc degeneration 20.77 9.63 13 182162 13239 46490648
Escherichia sepsis 20.76 9.63 49 182126 4189 46499698
Drug reaction with eosinophilia and systemic symptoms 20.72 9.63 191 181984 29357 46474530
Infectious thyroiditis 20.69 9.63 7 182168 28 46503859
Tooth disorder 20.67 9.63 37 182138 23266 46480621
Coma 20.61 9.63 138 182037 58211 46445676
Asthma 20.58 9.63 485 181690 91057 46412830
Procedural pain 20.55 9.63 13 182162 13166 46490721
Disability 20.53 9.63 7 182168 10160 46493727
Vertigo 20.50 9.63 119 182056 51929 46451958
Adactyly 20.50 9.63 7 182168 29 46503858
Morganella infection 20.49 9.63 16 182159 454 46503433
Diffuse panbronchiolitis 20.41 9.63 5 182170 3 46503884
Jaw operation 20.38 9.63 20 182155 775 46503112
Gastropleural fistula 20.36 9.63 8 182167 53 46503834
Blood fibrinogen decreased 20.35 9.63 19 182156 691 46503196
Varicella 20.34 9.63 29 182146 1677 46502210
T-cell lymphoma 20.32 9.63 18 182157 611 46503276
Paraneoplastic pemphigus 20.31 9.63 7 182168 30 46503857
Lymphocyte stimulation test positive 20.30 9.63 18 182157 612 46503275
Otospondylomegaepiphyseal dysplasia 20.26 9.63 9 182166 84 46503803
Retching 20.20 9.63 13 182162 13044 46490843
Human herpesvirus 6 infection reactivation 20.13 9.63 6 182169 14 46503873
Femur fracture 20.12 9.63 227 181948 36770 46467117
Thyroid disorder 20.12 9.63 11 182164 12065 46491822
Atypical fracture 20.11 9.63 17 182158 541 46503346
Lymphatic fistula 20.11 9.63 21 182154 877 46503010
Passenger lymphocyte syndrome 20.11 9.63 8 182167 55 46503832
Pneumonia haemophilus 20.04 9.63 17 182158 544 46503343
Blood lactate dehydrogenase abnormal 20.03 9.63 13 182162 273 46503614
Pericarditis constrictive 20.02 9.63 14 182161 334 46503553
Legionella infection 20.01 9.63 15 182160 400 46503487
Septic arthritis staphylococcal 19.95 9.63 15 182160 402 46503485
Lung adenocarcinoma 19.94 9.63 48 182127 4156 46499731
Femoral hernia incarcerated 19.89 9.63 21 182154 888 46502999
Irritability 19.86 9.63 53 182122 28893 46474994
Retinal drusen 19.83 9.63 5 182170 4 46503883
Glossopharyngeal nerve paralysis 19.83 9.63 5 182170 4 46503883
Loss of personal independence in daily activities 19.82 9.63 136 182039 57047 46446840
Temperature intolerance 19.81 9.63 3 182172 7604 46496283
Veillonella infection 19.78 9.63 7 182168 33 46503854
Cleft palate 19.74 9.63 21 182154 896 46502991
Eczema herpeticum 19.64 9.63 9 182166 91 46503796
IgA nephropathy 19.63 9.63 15 182160 412 46503475
Glomerulonephritis proliferative 19.63 9.63 11 182164 175 46503712
Musculoskeletal disorder 19.61 9.63 19 182156 15526 46488361
Device related infection 19.58 9.63 145 182030 20896 46482991
Cerebellar stroke 19.57 9.63 11 182164 176 46503711
HELLP syndrome 19.57 9.63 21 182154 905 46502982
Pneumonia acinetobacter 19.57 9.63 6 182169 16 46503871
Adenoviral haemorrhagic cystitis 19.55 9.63 10 182165 131 46503756
Antinuclear antibody negative 19.54 9.63 12 182163 228 46503659
Cellulitis 19.53 9.63 384 181791 69904 46433983
Stenosis 19.51 9.63 20 182155 817 46503070
Febrile bone marrow aplasia 19.43 9.63 65 182110 6797 46497090
Premature rupture of membranes 19.39 9.63 49 182126 4374 46499513
Status asthmaticus 19.39 9.63 21 182154 915 46502972
Anal abscess 19.38 9.63 43 182132 3529 46500358
Colitis 19.35 9.63 227 181948 37120 46466767
Respiratory tract congestion 19.35 9.63 13 182162 12751 46491136
Tooth infection 19.32 9.63 12 182163 12274 46491613
Acute lymphocytic leukaemia 19.31 9.63 37 182138 2736 46501151
Retinitis viral 19.31 9.63 5 182170 5 46503882
Streptococcal infection 19.30 9.63 52 182123 4826 46499061
Product storage error 19.28 9.63 11 182164 11781 46492106
Bone tuberculosis 19.20 9.63 11 182164 183 46503704
Acne 19.17 9.63 30 182145 19889 46483998
Trichosporon infection 19.14 9.63 12 182163 237 46503650
Mobility decreased 19.13 9.63 148 182027 60446 46443441
Nail pigmentation 19.09 9.63 11 182164 185 46503702
Device breakage 19.01 9.63 7 182168 9685 46494202
Fear 19.00 9.63 21 182154 16151 46487736
Ganglioneuroma 18.97 9.63 10 182165 140 46503747
Myelopathy 18.95 9.63 35 182140 2517 46501370
Systemic scleroderma 18.94 9.63 20 182155 846 46503041
Congenital oral malformation 18.94 9.63 11 182164 188 46503699
Atrial septal defect 18.84 9.63 61 182114 6271 46497616
Thoracic vertebral fracture 18.77 9.63 46 182129 4029 46499858
Leiomyosarcoma 18.73 9.63 11 182164 192 46503695
Diverticulum intestinal 18.71 9.63 59 182116 5982 46497905
Uterine perforation 18.62 9.63 3 182172 7264 46496623
Ureaplasma infection 18.61 9.63 15 182160 446 46503441
Limb discomfort 18.60 9.63 38 182137 22738 46481149
Polymyositis 18.59 9.63 27 182148 1588 46502299
Calculus urinary 18.54 9.63 20 182155 867 46503020
Chronic graft versus host disease in skin 18.52 9.63 17 182158 605 46503282
Symblepharon 18.46 9.63 8 182167 70 46503817
Scleral disorder 18.44 9.63 9 182166 106 46503781
Joint injury 18.42 9.63 29 182146 19180 46484707
Lymphoma transformation 18.42 9.63 10 182165 149 46503738
Respiratory gas exchange disorder 18.40 9.63 14 182161 382 46503505
Lipomatosis 18.39 9.63 7 182168 42 46503845
Keratitis 18.37 9.63 34 182141 2449 46501438
PO2 decreased 18.33 9.63 26 182149 1496 46502391
Macular fibrosis 18.28 9.63 14 182161 386 46503501
Intestinal tuberculosis 18.26 9.63 8 182167 72 46503815
Transaminases increased 18.25 9.63 177 181998 27584 46476303
Product substitution issue 18.24 9.63 19 182156 15012 46488875
Renal dysplasia 18.19 9.63 10 182165 153 46503734
Tooth fracture 18.14 9.63 7 182168 9408 46494479
Stevens-Johnson syndrome 18.09 9.63 154 182021 23143 46480744
Fungal test positive 18.09 9.63 16 182159 542 46503345
Nasal septum disorder 18.07 9.63 9 182166 111 46503776
Immune-mediated myositis 18.01 9.63 20 182155 896 46502991
Hypopharyngeal cancer 18.00 9.63 5 182170 8 46503879
Peripheral circulatory failure 18.00 9.63 13 182162 327 46503560
Abdominal distension 17.99 9.63 191 181984 73160 46430727
Reticulocytopenia 17.98 9.63 8 182167 75 46503812
Shock haemorrhagic 17.97 9.63 74 182101 8550 46495337
Coxsackie viral infection 17.94 9.63 6 182169 23 46503864
Placental insufficiency 17.93 9.63 24 182151 1307 46502580
Periodontitis 17.92 9.63 41 182134 3435 46500452
Pseudarthrosis 17.85 9.63 14 182161 400 46503487
Rash vesicular 17.83 9.63 41 182134 3446 46500441
Upper limb fracture 17.82 9.63 21 182154 15692 46488195
Aortic aneurysm rupture 17.80 9.63 16 182159 554 46503333
Tooth dislocation 17.74 9.63 6 182169 24 46503863
Extrapyramidal disorder 17.73 9.63 11 182164 11257 46492630
Ulcerative keratitis 17.73 9.63 32 182143 2261 46501626
Gastroenteritis viral 17.72 9.63 27 182148 18092 46485795
Oral herpes 17.69 9.63 133 182042 19257 46484630
Gastroenteritis norovirus 17.67 9.63 26 182149 1547 46502340
Abnormal dreams 17.66 9.63 9 182166 10270 46493617
Mucinous adenocarcinoma of appendix 17.64 9.63 5 182170 9 46503878
Torsade de pointes 17.61 9.63 13 182162 12141 46491746
Diffuse large B-cell lymphoma stage IV 17.60 9.63 11 182164 216 46503671
Cardiac myxoma 17.60 9.63 11 182164 216 46503671
Mycobacterium kansasii infection 17.59 9.63 9 182166 118 46503769
Prinzmetal angina 17.53 9.63 18 182157 737 46503150
Hepatitis viral 17.52 9.63 14 182161 411 46503476
Fungal sepsis 17.51 9.63 22 182153 1125 46502762
Cutaneous leishmaniasis 17.44 9.63 8 182167 81 46503806
Conjunctival oedema 17.44 9.63 16 182159 569 46503318
Skin discolouration 17.41 9.63 67 182108 32613 46471274
Brain stem infarction 17.39 9.63 19 182156 836 46503051
Omental necrosis 17.30 9.63 5 182170 10 46503877
Large intestine erosion 17.30 9.63 5 182170 10 46503877
Airway peak pressure increased 17.25 9.63 12 182163 284 46503603
Haemorrhagic diathesis 17.23 9.63 42 182133 3666 46500221
Brain compression 17.11 9.63 13 182162 354 46503533
No adverse event 17.09 9.63 72 182103 34159 46469728
Hepatic cyst 17.07 9.63 49 182126 4717 46499170
Fibrin degradation products increased 17.06 9.63 10 182165 174 46503713
Umbilical cord abnormality 17.05 9.63 16 182159 586 46503301
Sudden hearing loss 17.04 9.63 22 182153 1156 46502731
Pelvic deformity 16.99 9.63 11 182164 230 46503657
Polyneuropathy 16.96 9.63 90 182085 11554 46492333
Drug ineffective for unapproved indication 16.96 9.63 116 182059 16297 46487590
Cloacal exstrophy 16.95 9.63 9 182166 128 46503759
Eosinophilic myocarditis 16.92 9.63 13 182162 360 46503527
Ileal ulcer 16.90 9.63 14 182161 433 46503454
Keratopathy 16.89 9.63 12 182163 294 46503593
Pseudomonal sepsis 16.85 9.63 29 182146 1973 46501914
Keratitis bacterial 16.83 9.63 6 182169 29 46503858
Diffuse alveolar damage 16.83 9.63 18 182157 773 46503114
Anal ulcer 16.82 9.63 14 182161 436 46503451
Beta 2 microglobulin urine increased 16.80 9.63 7 182168 55 46503832
Epistaxis 16.78 9.63 165 182010 64140 46439747
Anger 16.75 9.63 13 182162 11839 46492048
Ruptured cerebral aneurysm 16.74 9.63 14 182161 439 46503448
Dysphagia 16.74 9.63 207 181968 77105 46426782
Pneumocystis test positive 16.68 9.63 5 182170 12 46503875
Hypozincaemia 16.68 9.63 5 182170 12 46503875
Retrognathia 16.68 9.63 12 182163 300 46503587
Urticaria 16.67 9.63 342 181833 117550 46386337
Mycotic endophthalmitis 16.67 9.63 6 182169 30 46503857
Oxygen saturation decreased 16.60 9.63 181 181994 68983 46434904
Blood immunoglobulin M decreased 16.59 9.63 17 182158 694 46503193
Granuloma 16.57 9.63 42 182133 3756 46500131
Gestational hypertension 16.57 9.63 30 182145 2125 46501762
Central nervous system fungal infection 16.55 9.63 8 182167 92 46503795
Myalgia 16.55 9.63 360 181815 122728 46381159
Microangiopathic haemolytic anaemia 16.50 9.63 14 182161 448 46503439
Pulmonary artery thrombosis 16.49 9.63 17 182158 699 46503188
Hip fracture 16.48 9.63 51 182124 26505 46477382
Rhabdomyolysis 16.41 9.63 96 182079 41813 46462074
Anuria 16.41 9.63 88 182087 11343 46492544
Palpitations 16.40 9.63 267 181908 94992 46408895
Cytomegalovirus duodenitis 16.40 9.63 5 182170 13 46503874
Bone infarction 16.39 9.63 11 182164 245 46503642
Hydrocephalus 16.38 9.63 49 182126 4828 46499059
Retinitis 16.35 9.63 13 182162 379 46503508
Human herpesvirus 6 infection 16.32 9.63 32 182143 2407 46501480
Agitation 16.28 9.63 138 182037 55277 46448610
Histoplasmosis 16.26 9.63 26 182149 1664 46502223
Abortion missed 16.26 9.63 25 182150 1547 46502340
Megacolon 16.25 9.63 26 182149 1665 46502222
Rectal cancer metastatic 16.23 9.63 11 182164 249 46503638
Staphylococcal bacteraemia 16.21 9.63 49 182126 4855 46499032
Small intestine ulcer 16.20 9.63 12 182163 314 46503573
Leukaemia cutis 16.18 9.63 8 182167 97 46503790
Interleukin-2 receptor increased 16.17 9.63 7 182168 61 46503826
Extradural abscess 16.16 9.63 17 182158 716 46503171
Large intestinal ulcer 16.15 9.63 37 182138 3102 46500785
Squamous cell carcinoma 16.14 9.63 67 182108 7769 46496118
Herpes zoster meningoencephalitis 16.12 9.63 11 182164 252 46503635
Hypoglycaemia 16.12 9.63 135 182040 54214 46449673
Diverticulum intestinal haemorrhagic 16.12 9.63 22 182153 1221 46502666
Blood pressure diastolic decreased 16.11 9.63 19 182156 14192 46489695
Congenital hydronephrosis 16.03 9.63 13 182162 390 46503497
Polymyalgia rheumatica 16.01 9.63 31 182144 2311 46501576
Central obesity 15.99 9.63 18 182157 819 46503068
Cytomegalovirus mucocutaneous ulcer 15.97 9.63 4 182171 3 46503884
Nodal marginal zone B-cell lymphoma 15.97 9.63 4 182171 3 46503884
Heart transplant rejection 15.93 9.63 14 182161 470 46503417
Myocardial infarction 15.93 9.63 276 181899 97252 46406635
Kidney rupture 15.91 9.63 6 182169 35 46503852
Oropharyngeal pain 15.90 9.63 199 181976 73969 46429918
Parvovirus infection 15.88 9.63 10 182165 199 46503688
Subclavian artery embolism 15.88 9.63 5 182170 15 46503872
Hepatic enzyme increased 15.87 9.63 224 181951 81563 46422324
Cryptosporidiosis infection 15.86 9.63 11 182164 259 46503628
Intraductal papillary mucinous neoplasm 15.82 9.63 11 182164 260 46503627
Cerebellar infarction 15.82 9.63 27 182148 1825 46502062
Hodgkin's disease 15.80 9.63 18 182157 830 46503057
Lymphocytosis 15.80 9.63 30 182145 2204 46501683
Body height decreased 15.78 9.63 9 182166 9643 46494244
Lung lobectomy 15.76 9.63 8 182167 103 46503784
Lung consolidation 15.76 9.63 41 182134 3726 46500161
Pulmonary sepsis 15.75 9.63 23 182152 1359 46502528
Hypersensitivity pneumonitis 15.72 9.63 31 182144 2342 46501545
Glucose tolerance impaired 15.72 9.63 48 182127 4783 46499104
Anal fistula 15.71 9.63 33 182142 2608 46501279
Stenotrophomonas infection 15.70 9.63 25 182150 1595 46502292
Transplant dysfunction 15.68 9.63 47 182128 4635 46499252
Complications of transplanted liver 15.67 9.63 13 182162 403 46503484
Asteatosis 15.61 9.63 7 182168 67 46503820
Post transplant distal limb syndrome 15.58 9.63 10 182165 206 46503681
Genital neoplasm malignant female 15.56 9.63 8 182167 106 46503781
Orthostatic hypotension 15.55 9.63 47 182128 24611 46479276
Haptoglobin decreased 15.55 9.63 15 182160 569 46503318
Bone pain 15.53 9.63 113 182062 46777 46457110
Wound dehiscence 15.52 9.63 46 182129 4508 46499379
Megakaryocytes increased 15.50 9.63 6 182169 38 46503849
Lung transplant rejection 15.49 9.63 17 182158 752 46503135
Coagulation test abnormal 15.46 9.63 16 182159 661 46503226
Chronic gastritis 15.45 9.63 31 182144 2372 46501515
Reticulin increased 15.44 9.63 4 182171 4 46503883
Vagus nerve paralysis 15.44 9.63 4 182171 4 46503883
Transplant abscess 15.44 9.63 4 182171 4 46503883
Lymphadenopathy 15.39 9.63 199 181976 33289 46470598
Amniotic fluid volume increased 15.38 9.63 9 182166 156 46503731
Duodenal stenosis 15.37 9.63 15 182160 577 46503310
Myelomalacia 15.36 9.63 6 182169 39 46503848
Ulna fracture 15.27 9.63 20 182155 1066 46502821
Increased tendency to bruise 15.26 9.63 9 182166 9465 46494422
Histiocytic sarcoma 15.25 9.63 7 182168 71 46503816
Encephalomyelitis 15.24 9.63 8 182167 111 46503776
Tubular breast carcinoma 15.24 9.63 6 182169 40 46503847
Chest discomfort 15.21 9.63 254 181921 90015 46413872
Abdominal compartment syndrome 15.18 9.63 15 182160 586 46503301
Skin striae 15.17 9.63 20 182155 1073 46502814
Aphonia 15.15 9.63 6 182169 7939 46495948
Small cell lung cancer 15.14 9.63 24 182151 1525 46502362
Pleocytosis 15.12 9.63 14 182161 504 46503383
Transient hypogammaglobulinaemia of infancy 15.11 9.63 6 182169 41 46503846
Conjunctival ulcer 15.11 9.63 6 182169 41 46503846
Patent ductus arteriosus 15.11 9.63 41 182134 3821 46500066
Tuberculosis gastrointestinal 15.09 9.63 12 182163 350 46503537
Infective aneurysm 15.09 9.63 13 182162 425 46503462
Epstein-Barr virus associated lymphoma 15.08 9.63 11 182164 281 46503606
Herpes virus infection 15.08 9.63 47 182128 4735 46499152
Hepatic fibrosis 15.08 9.63 35 182140 2960 46500927
Corneal scar 15.05 9.63 8 182167 114 46503773
Necrotising retinitis 15.05 9.63 11 182164 282 46503605
Clubbing 15.05 9.63 11 182164 282 46503605
Ocular hypertension 15.04 9.63 17 182158 777 46503110
Meconium stain 14.99 9.63 9 182166 164 46503723
Henoch-Schonlein purpura nephritis 14.98 9.63 5 182170 19 46503868
Lymphoplasmacytoid lymphoma/immunocytoma 14.98 9.63 4 182171 5 46503882
Cytomegalovirus gastrointestinal ulcer 14.98 9.63 4 182171 5 46503882
Aspergillus test 14.98 9.63 4 182171 5 46503882
Cardiovascular disorder 14.97 9.63 90 182085 12097 46491790
Gastroenteritis salmonella 14.88 9.63 13 182162 433 46503454
Protein urine present 14.88 9.63 49 182126 5082 46498805
Jejunal stenosis 14.87 9.63 6 182169 43 46503844
Pelvic pain 14.84 9.63 14 182161 11588 46492299
Aspergilloma 14.84 9.63 9 182166 167 46503720
Pneumonia staphylococcal 14.83 9.63 33 182142 2714 46501173
Leiomyoma 14.80 9.63 12 182163 360 46503527
Dengue fever 14.79 9.63 15 182160 605 46503282
Myasthenia gravis 14.78 9.63 38 182137 3428 46500459
Hepatic amoebiasis 14.78 9.63 5 182170 20 46503867
Mechanical ileus 14.78 9.63 11 182164 290 46503597
Abscess intestinal 14.77 9.63 22 182153 1324 46502563
Encephalitis autoimmune 14.73 9.63 20 182155 1104 46502783
Chronic hepatitis C 14.66 9.63 9 182166 171 46503716
Enterocolitis viral 14.66 9.63 10 182165 229 46503658
Visceral leishmaniasis 14.63 9.63 13 182162 443 46503444
Bladder agenesis 14.63 9.63 8 182167 121 46503766
Hypoproteinaemia 14.61 9.63 26 182149 1817 46502070
Meningomyelitis herpes 14.59 9.63 5 182170 21 46503866
Aortitis 14.59 9.63 16 182159 707 46503180
Subclavian vein thrombosis 14.58 9.63 26 182149 1820 46502067
Gram stain positive 14.56 9.63 4 182171 6 46503881
Factor VIII deficiency 14.56 9.63 4 182171 6 46503881
Gastric ulcer perforation 14.55 9.63 20 182155 1117 46502770
Abdominal abscess 14.54 9.63 42 182133 4057 46499830
Facial paralysis 14.50 9.63 95 182080 13155 46490732
Paradoxical drug reaction 14.50 9.63 30 182145 2346 46501541
PCO2 increased 14.48 9.63 21 182154 1233 46502654
Osteomyelitis bacterial 14.48 9.63 9 182166 175 46503712
Akathisia 14.43 9.63 6 182169 7708 46496179
Generalised oedema 14.42 9.63 101 182074 14298 46489589
Blood creatine phosphokinase decreased 14.36 9.63 12 182163 376 46503511
Thrombophlebitis 14.35 9.63 44 182131 4393 46499494
Vogt-Koyanagi-Harada disease 14.35 9.63 8 182167 126 46503761
Gastrointestinal perforation 14.34 9.63 36 182139 3201 46500686
Peritonitis viral 14.31 9.63 6 182169 48 46503839
Knee arthroplasty 14.29 9.63 46 182129 23619 46480268
Mood swings 14.24 9.63 26 182149 16226 46487661
Impaired work ability 14.21 9.63 17 182158 12619 46491268
Infusion site erythema 14.20 9.63 6 182169 7636 46496251
Toxic cardiomyopathy 14.18 9.63 8 182167 129 46503758
Fulminant type 1 diabetes mellitus 14.18 9.63 10 182165 242 46503645
Blood pressure diastolic increased 14.16 9.63 3 182172 5971 46497916
Chronic hepatitis B 14.07 9.63 10 182165 245 46503642
Gastric disorder 14.07 9.63 55 182120 26650 46477237
Herpangina 14.06 9.63 5 182170 24 46503863
Visual acuity reduced 14.05 9.63 140 182035 21973 46481914
Aphthous ulcer 14.04 9.63 74 182101 9474 46494413
Acute hepatitis B 14.03 9.63 11 182164 314 46503573
Infarction 13.98 9.63 29 182146 2272 46501615
Impaired gastric emptying 13.97 9.63 7 182168 8065 46495822
Duodenal perforation 13.96 9.63 17 182158 842 46503045
Treatment noncompliance 13.95 9.63 64 182111 29667 46474220
Lung opacity 13.93 9.63 20 182155 1164 46502723
Joint space narrowing 13.91 9.63 8 182167 134 46503753
Product complaint 13.91 9.63 16 182159 12085 46491802
Tardive dyskinesia 13.89 9.63 6 182169 7537 46496350
Iris transillumination defect 13.89 9.63 6 182169 52 46503835
Malacoplakia vesicae 13.89 9.63 6 182169 52 46503835
Aneurysm ruptured 13.88 9.63 13 182162 475 46503412
Vasogenic cerebral oedema 13.88 9.63 13 182162 475 46503412
Infection susceptibility increased 13.88 9.63 28 182147 2151 46501736
Genitalia external ambiguous 13.86 9.63 8 182167 135 46503752
Chorioretinitis 13.85 9.63 11 182164 320 46503567
Infective aortitis 13.84 9.63 4 182171 8 46503879
Gardner-Diamond syndrome 13.84 9.63 4 182171 8 46503879
Concussion 13.84 9.63 5 182170 6998 46496889
Osteoarthritis 13.83 9.63 165 182010 61860 46442027
Cytomegalovirus gastritis 13.83 9.63 9 182166 190 46503697
Pulmonary mucormycosis 13.80 9.63 7 182168 90 46503797
Gastrointestinal oedema 13.80 9.63 19 182156 1063 46502824
Remission not achieved 13.80 9.63 7 182168 90 46503797
Pneumonia chlamydial 13.79 9.63 6 182169 53 46503834
Collagen disorder 13.79 9.63 9 182166 191 46503696
Glucose urine present 13.78 9.63 15 182160 657 46503230
Epstein-Barr virus test positive 13.78 9.63 14 182161 566 46503321
Graft complication 13.75 9.63 9 182166 192 46503695
Feeling hot 13.75 9.63 89 182086 37839 46466048
Exposure via body fluid 13.74 9.63 13 182162 481 46503406
Evans syndrome 13.71 9.63 9 182166 193 46503694
Oral mucosa erosion 13.69 9.63 19 182156 1071 46502816
Road traffic accident 13.66 9.63 47 182128 23644 46480243
Gastroenteritis sapovirus 13.65 9.63 3 182172 0 46503887
Bezold abscess 13.65 9.63 3 182172 0 46503887
Endotoxic shock 13.65 9.63 3 182172 0 46503887
Glucose tolerance decreased 13.65 9.63 3 182172 0 46503887
Nocardia sepsis 13.65 9.63 3 182172 0 46503887
Osteomyelitis salmonella 13.65 9.63 3 182172 0 46503887
Tuberculous tenosynovitis 13.65 9.63 3 182172 0 46503887
Meningoencephalitis amoebic 13.65 9.63 3 182172 0 46503887
Anti-glomerular basement membrane antibody positive 13.65 9.63 3 182172 0 46503887
Respiratory tract infection fungal 13.60 9.63 12 182163 405 46503482
Peliosis hepatis 13.60 9.63 6 182169 55 46503832
Vertebral artery occlusion 13.60 9.63 7 182168 93 46503794
Retinal haemorrhage 13.60 9.63 46 182129 4837 46499050
Microtia 13.59 9.63 11 182164 329 46503558
Exostosis 13.59 9.63 12 182163 10251 46493636
Skin necrosis 13.57 9.63 68 182107 8536 46495351
Caesarean section 13.56 9.63 111 182064 16492 46487395
Blood cholinesterase decreased 13.56 9.63 8 182167 141 46503746
Injection site discolouration 13.54 9.63 5 182170 6905 46496982
Cryptococcus test positive 13.52 9.63 4 182171 9 46503878
Conjunctival deposit 13.52 9.63 4 182171 9 46503878
Picornavirus infection 13.52 9.63 4 182171 9 46503878
Hirsutism 13.51 9.63 18 182157 976 46502911
Post herpetic neuralgia 13.46 9.63 26 182149 1934 46501953
Mouth ulceration 13.42 9.63 162 182013 26670 46477217
Antineutrophil cytoplasmic antibody increased 13.42 9.63 6 182169 57 46503830
Ureteral necrosis 13.42 9.63 6 182169 57 46503830
Cytopenia 13.41 9.63 63 182112 7705 46496182
Chronic inflammatory demyelinating polyradiculoneuropathy 13.40 9.63 11 182164 336 46503551
Renal infarct 13.38 9.63 20 182155 1207 46502680
Giant cell arteritis 13.36 9.63 25 182150 1816 46502071
Corneal epithelium defect 13.34 9.63 11 182164 338 46503549
Pseudo-Bartter syndrome 13.32 9.63 6 182169 58 46503829
Haematocolpos 13.32 9.63 6 182169 58 46503829
Hepatitis C RNULL increased 13.31 9.63 8 182167 146 46503741
Haematoma infection 13.30 9.63 13 182162 501 46503386
Blood pressure diastolic abnormal 13.30 9.63 4 182171 6290 46497597
Renal cell carcinoma 13.28 9.63 37 182138 3501 46500386
Jejunal perforation 13.28 9.63 7 182168 98 46503789
Small intestinal ulcer haemorrhage 13.24 9.63 6 182169 59 46503828
Limb injury 13.23 9.63 35 182140 19139 46484748
Antineutrophil cytoplasmic antibody 13.23 9.63 4 182171 10 46503877
Pleural infection bacterial 13.23 9.63 4 182171 10 46503877
Tongue necrosis 13.23 9.63 4 182171 10 46503877
Calciphylaxis 13.18 9.63 30 182145 2505 46501382
Cutaneous T-cell lymphoma 13.16 9.63 21 182154 1342 46502545
Oligodendroglioma 13.14 9.63 5 182170 30 46503857
Herpes simplex sepsis 13.14 9.63 5 182170 30 46503857
Tethered cord syndrome 13.12 9.63 9 182166 208 46503679
Pneumonia legionella 13.11 9.63 21 182154 1346 46502541
Lactic acidosis 13.10 9.63 78 182097 33831 46470056
Hydronephrosis 13.10 9.63 67 182108 8478 46495409
Hypopyon 13.09 9.63 16 182159 795 46503092
Cholecystitis chronic 13.05 9.63 13 182162 10486 46493401
Aplasia 13.04 9.63 37 182138 3539 46500348
Peritonsillar abscess 13.01 9.63 13 182162 515 46503372
Dysphonia 13.00 9.63 92 182083 38322 46465565
Postoperative wound infection 12.98 9.63 68 182107 8685 46495202
Dermatitis allergic 12.98 9.63 89 182086 12514 46491373
Vascular pseudoaneurysm 12.97 9.63 21 182154 1359 46502528
Ileal perforation 12.96 9.63 11 182164 352 46503535
Herpes simplex pneumonia 12.96 9.63 4 182171 11 46503876
Febrile infection 12.94 9.63 20 182155 1243 46502644
Tendon pain 12.94 9.63 32 182143 2818 46501069
Renal tubular atrophy 12.93 9.63 13 182162 519 46503368
Gastric stenosis 12.89 9.63 6 182169 63 46503824
Disseminated varicella zoster vaccine virus infection 12.89 9.63 6 182169 63 46503824
Influenza B virus test positive 12.89 9.63 11 182164 355 46503532
Nerve injury 12.87 9.63 7 182168 7698 46496189
Hypersensitivity vasculitis 12.86 9.63 41 182134 4180 46499707
Fracture 12.85 9.63 109 182066 16362 46487525
Venous thrombosis limb 12.85 9.63 32 182143 2831 46501056
Poor quality sleep 12.84 9.63 25 182150 15228 46488659
Ophthalmic herpes simplex 12.83 9.63 10 182165 283 46503604
Epstein-Barr viraemia 12.65 9.63 15 182160 722 46503165
Aortic arteriosclerosis 12.64 9.63 50 182125 5671 46498216
Acute graft versus host disease in liver 12.63 9.63 14 182161 626 46503261
Haemolysis 12.63 9.63 52 182123 6007 46497880
Herpes simplex viraemia 12.63 9.63 8 182167 161 46503726
Jejunal ulcer perforation 12.61 9.63 5 182170 34 46503853
Non-cardiac chest pain 12.60 9.63 4 182171 6074 46497813
Infertility 12.60 9.63 14 182161 628 46503259
Central nervous system infection 12.60 9.63 14 182161 628 46503259
Intestinal ischaemia 12.57 9.63 57 182118 6868 46497019
Herpes simplex hepatitis 12.56 9.63 10 182165 292 46503595
Thrombosis 12.56 9.63 149 182026 55920 46447967
Myasthenia gravis crisis 12.55 9.63 11 182164 368 46503519
Speech disorder 12.54 9.63 86 182089 36081 46467806
Extranodal marginal zone B-cell lymphoma (MALT type) 12.51 9.63 12 182163 452 46503435
Labelled drug-drug interaction medication error 12.49 9.63 69 182106 8992 46494895
Gastritis 12.48 9.63 196 181979 34182 46469705
Blood potassium decreased 12.47 9.63 92 182083 37971 46465916
Nightmare 12.47 9.63 29 182146 16569 46487318
Still's disease 12.46 9.63 4 182171 13 46503874
Lymphadenitis bacterial 12.46 9.63 4 182171 13 46503874
Meningitis enteroviral 12.46 9.63 4 182171 13 46503874
Sweat gland tumour 12.46 9.63 7 182168 112 46503775
Immunodeficiency common variable 12.46 9.63 7 182168 112 46503775
Joint tuberculosis 12.46 9.63 7 182168 112 46503775
Stress fracture 12.45 9.63 58 182117 7069 46496818
Non-Hodgkin's lymphoma 12.42 9.63 22 182153 1532 46502355
Polymicrogyria 12.42 9.63 6 182169 69 46503818
Dermal sinus 12.37 9.63 5 182170 36 46503851
Pharyngitis streptococcal 12.34 9.63 9 182166 8459 46495428
Foetal death 12.34 9.63 67 182108 8676 46495211
Gouty tophus 12.33 9.63 8 182167 168 46503719
Tonsillitis 12.30 9.63 45 182130 4919 46498968
Pyometra 12.29 9.63 7 182168 115 46503772
Pneumonitis chemical 12.29 9.63 8 182167 169 46503718
Haemobilia 12.27 9.63 6 182169 71 46503816
Beta-N-acetyl-D-glucosaminidase increased 12.25 9.63 5 182170 37 46503850
Feeding disorder 12.24 9.63 13 182162 10181 46493706
Community acquired infection 12.24 9.63 4 182171 14 46503873
Rheumatoid lung 12.23 9.63 23 182152 1677 46502210
Endothelial dysfunction 12.19 9.63 7 182168 117 46503770
Congenital genital malformation 12.19 9.63 7 182168 117 46503770
Anal cancer 12.18 9.63 12 182163 467 46503420
Depressed mood 12.17 9.63 78 182097 33241 46470646
Lymphocyte count decreased 12.15 9.63 153 182022 25436 46478451
Paraspinal abscess 12.14 9.63 5 182170 38 46503849
Infective glossitis 12.14 9.63 5 182170 38 46503849
Cutaneous lupus erythematosus 12.13 9.63 29 182146 2500 46501387
Lip swelling 12.13 9.63 152 182023 25243 46478644
Device leakage 12.11 9.63 3 182172 5362 46498525
Neonatal respiratory distress syndrome 12.10 9.63 29 182146 2504 46501383
Abscess neck 12.08 9.63 13 182162 562 46503325
Lichenification 12.06 9.63 11 182164 388 46503499
Antimitochondrial antibody positive 12.05 9.63 6 182169 74 46503813
Blood lactate dehydrogenase decreased 12.05 9.63 6 182169 74 46503813
Steatorrhoea 12.04 9.63 11 182164 389 46503498
Chronic graft versus host disease oral 12.03 9.63 5 182170 39 46503848
Lymphangioma 12.03 9.63 4 182171 15 46503872
Lentigo maligna 12.00 9.63 8 182167 176 46503711
Haemorrhagic ascites 11.98 9.63 7 182168 121 46503766
Acute psychosis 11.98 9.63 25 182150 1967 46501920
Dermatitis psoriasiform 11.97 9.63 23 182152 1704 46502183
Duodenal ulcer haemorrhage 11.97 9.63 28 182147 2380 46501507
Ear pain 11.96 9.63 45 182130 22047 46481840
Cushing's syndrome 11.95 9.63 15 182160 766 46503121
Tracheobronchitis 11.95 9.63 18 182157 1094 46502793
Neuralgia 11.94 9.63 43 182132 21340 46482547
Myeloproliferative neoplasm 11.93 9.63 12 182163 479 46503408
Flatulence 11.93 9.63 65 182110 28813 46475074
Localised infection 11.92 9.63 50 182125 23751 46480136
Candida infection 11.89 9.63 136 182039 22104 46481783
Salmonellosis 11.87 9.63 16 182159 877 46503010
Helicobacter gastritis 11.87 9.63 21 182154 1461 46502426
Muscle haemorrhage 11.86 9.63 34 182141 3270 46500617
Normochromic anaemia 11.85 9.63 9 182166 245 46503642
Blood immunoglobulin M increased 11.82 9.63 9 182166 246 46503641
Micturition urgency 11.80 9.63 8 182167 7809 46496078
Hysterectomy 11.77 9.63 8 182167 7798 46496089
Back disorder 11.73 9.63 11 182164 9130 46494757
Eye irritation 11.72 9.63 30 182145 16584 46487303
Needle issue 11.71 9.63 4 182171 5800 46498087
Diffuse large B-cell lymphoma stage III 11.71 9.63 5 182170 42 46503845
Parophthalmia 11.69 9.63 9 182166 250 46503637
Graft versus host disease in lung 11.68 9.63 10 182165 324 46503563
Gouty arthritis 11.61 9.63 12 182163 495 46503392
Female reproductive neoplasm 11.61 9.63 5 182170 43 46503844
Caudal regression syndrome 11.59 9.63 7 182168 129 46503758
Urinary occult blood positive 11.58 9.63 3 182172 3 46503884
Right atrial hypertrophy 11.58 9.63 3 182172 3 46503884
Conjunctival neoplasm 11.58 9.63 3 182172 3 46503884
Retinal infiltrates 11.58 9.63 3 182172 3 46503884
Malignant glaucoma 11.58 9.63 3 182172 3 46503884
Middle insomnia 11.58 9.63 12 182163 9503 46494384
Gastroenteritis clostridial 11.53 9.63 12 182163 499 46503388
Oedematous pancreatitis 11.53 9.63 10 182165 330 46503557
Exposed bone in jaw 11.51 9.63 33 182142 3175 46500712
Sputum retention 11.49 9.63 11 182164 413 46503474
Cholecystectomy 11.46 9.63 11 182164 9031 46494856
Aspartate aminotransferase abnormal 11.45 9.63 16 182159 908 46502979
Enterocolitis bacterial 11.44 9.63 8 182167 191 46503696
Neurosarcoidosis 11.40 9.63 8 182167 192 46503695
Bone erosion 11.39 9.63 12 182163 9431 46494456
Enterovirus infection 11.38 9.63 13 182162 601 46503286
Intrauterine infection 11.38 9.63 6 182169 84 46503803
Dermatitis contact 11.37 9.63 9 182166 8114 46495773
Rectal haemorrhage 11.35 9.63 95 182080 38160 46465727
Pustular psoriasis 11.33 9.63 38 182137 3979 46499908
Encephalitis cytomegalovirus 11.32 9.63 12 182163 510 46503377
Gastrointestinal erosion 11.31 9.63 13 182162 605 46503282
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.31 9.63 24 182151 1911 46501976
Myelitis transverse 11.30 9.63 17 182158 1032 46502855
Lower limb fracture 11.29 9.63 85 182090 12313 46491574
Joint abscess 11.24 9.63 9 182166 265 46503622
Eye abscess 11.20 9.63 6 182169 87 46503800
Chronic myeloid leukaemia recurrent 11.19 9.63 8 182167 198 46503689
Cough 11.15 9.63 761 181414 229488 46274399
Complement factor decreased 11.13 9.63 5 182170 48 46503839
Sequestrectomy 11.13 9.63 17 182158 1046 46502841
Parotid abscess 11.12 9.63 3 182172 4 46503883
Malignant neoplasm of orbit 11.11 9.63 4 182171 20 46503867
Antibody test 11.11 9.63 4 182171 20 46503867
Volvulus of small bowel 11.11 9.63 4 182171 20 46503867
Locked-in syndrome 11.10 9.63 10 182165 347 46503540
Intestinal infarction 11.09 9.63 16 182159 935 46502952
Red blood cell abnormality 11.07 9.63 9 182166 271 46503616
Lipid metabolism disorder 11.04 9.63 5 182170 49 46503838
Pneumonia pseudomonal 11.03 9.63 25 182150 2081 46501806
Seroma 11.03 9.63 25 182150 2082 46501805
Eczema 11.02 9.63 125 182050 20275 46483612
Lividity 11.01 9.63 8 182167 203 46503684
Arthritis 11.01 9.63 224 181951 77092 46426795
Pouchitis 11.00 9.63 11 182164 436 46503451
Congenital musculoskeletal anomaly 11.00 9.63 11 182164 436 46503451
Upper respiratory tract irritation 10.96 9.63 5 182170 50 46503837
Craniosynostosis 10.96 9.63 7 182168 143 46503744
Leukoerythroblastic anaemia 10.95 9.63 4 182171 21 46503866
Crime 10.95 9.63 4 182171 21 46503866
Haemarthrosis 10.94 9.63 31 182144 2962 46500925
Soft tissue infection 10.93 9.63 24 182151 1956 46501931
Gene mutation 10.93 9.63 17 182158 1063 46502824
Product monitoring error 10.92 9.63 24 182151 1957 46501930
Autoimmune haemolytic anaemia 10.89 9.63 39 182136 4219 46499668
Bladder transitional cell carcinoma 10.89 9.63 12 182163 533 46503354
Klebsiella sepsis 10.86 9.63 19 182156 1310 46502577
Granuloma skin 10.85 9.63 34 182141 3436 46500451
Menstruation irregular 10.83 9.63 6 182169 6533 46497354
Gastrointestinal malformation 10.83 9.63 7 182168 146 46503741
Poisoning deliberate 10.82 9.63 9 182166 7917 46495970
Sensitivity to weather change 10.79 9.63 4 182171 5512 46498375
Endocarditis enterococcal 10.79 9.63 5 182170 52 46503835
Gastrointestinal haemorrhage 10.77 9.63 386 181789 76987 46426900
Human polyomavirus infection 10.75 9.63 8 182167 211 46503676
Necrosis 10.75 9.63 42 182133 4738 46499149
Vision blurred 10.75 9.63 233 181942 79475 46424412
Sclerema 10.73 9.63 3 182172 5 46503882
Movement disorder 10.71 9.63 32 182143 16817 46487070
Stomatococcal infection 10.68 9.63 6 182169 96 46503791
Wound 10.68 9.63 111 182064 42691 46461196
Optic atrophy 10.67 9.63 17 182158 1085 46502802
Periorbital pain 10.65 9.63 4 182171 23 46503864
Pseudomembranous colitis 10.63 9.63 32 182143 3163 46500724
Parotitis 10.63 9.63 18 182157 1209 46502678
Gastrointestinal candidiasis 10.62 9.63 6 182169 97 46503790
Pregnancy on contraceptive 10.61 9.63 17 182158 1090 46502797
Gastrointestinal disorder 10.58 9.63 166 182009 59410 46444477
Amyloidosis 10.57 9.63 17 182158 1094 46502793
Eye infection 10.55 9.63 12 182163 9111 46494776
Lipohypertrophy 10.52 9.63 14 182161 758 46503129
Corneal lesion 10.51 9.63 4 182171 24 46503863
Red blood cell sedimentation rate increased 10.51 9.63 136 182039 22753 46481134
Bronchitis 10.50 9.63 324 181851 105655 46398232
Drug dependence 10.47 9.63 41 182134 19860 46484027
Gastrointestinal disorder congenital 10.46 9.63 6 182169 100 46503787
Behcet's syndrome 10.46 9.63 6 182169 100 46503787
Muscle injury 10.45 9.63 3 182172 4863 46499024
Product prescribing error 10.45 9.63 122 182053 19925 46483962
Facial nerve disorder 10.43 9.63 12 182163 559 46503328
Alternaria infection 10.43 9.63 7 182168 156 46503731
Systemic mastocytosis 10.43 9.63 7 182168 156 46503731
Dacryoadenitis acquired 10.38 9.63 3 182172 6 46503881
Asplenia 10.38 9.63 3 182172 6 46503881
Submaxillary gland enlargement 10.38 9.63 3 182172 6 46503881
Renal cyst infection 10.36 9.63 6 182169 102 46503785
Protein-losing gastroenteropathy 10.35 9.63 7 182168 158 46503729
Hallucination 10.34 9.63 135 182040 49816 46454071
Abdominal tenderness 10.31 9.63 55 182120 7073 46496814
Left ventricular dysfunction 10.31 9.63 72 182103 10183 46493704
Mucocutaneous ulceration 10.31 9.63 7 182168 159 46503728
Grip strength decreased 10.31 9.63 11 182164 8595 46495292
Immune reconstitution inflammatory syndrome 10.30 9.63 47 182128 5678 46498209
Seasonal allergy 10.26 9.63 23 182152 13311 46490576
Bulbar palsy 10.24 9.63 4 182171 26 46503861
Muscular dystrophy 10.24 9.63 4 182171 26 46503861
Corneal graft rejection 10.24 9.63 4 182171 26 46503861
Hepatic rupture 10.24 9.63 4 182171 26 46503861
Transient ischaemic attack 10.21 9.63 87 182088 34816 46469071
Thrombotic thrombocytopenic purpura 10.16 9.63 36 182139 3874 46500013
Lupus myocarditis 10.16 9.63 5 182170 60 46503827
Urethritis 10.16 9.63 8 182167 230 46503657
Complications of transplanted lung 10.13 9.63 8 182167 231 46503656
Lacrimal haemorrhage 10.12 9.63 4 182171 27 46503860
Laparoscopic surgery 10.12 9.63 4 182171 27 46503860
Waxy flexibility 10.11 9.63 6 182169 107 46503780
Anal sphincter atony 10.10 9.63 8 182167 232 46503655
Ophthalmic herpes zoster 10.08 9.63 20 182155 1518 46502369
Biliary tract disorder 10.07 9.63 13 182162 683 46503204
Cutaneous nocardiosis 10.07 9.63 3 182172 7 46503880
Fibrosarcoma 10.07 9.63 3 182172 7 46503880
Thymoma malignant 10.07 9.63 3 182172 7 46503880
Plasminogen decreased 10.07 9.63 3 182172 7 46503880
Drug level fluctuating 10.05 9.63 10 182165 394 46503493
Injection site induration 10.05 9.63 10 182165 8069 46495818
B-cell lymphoma 10.04 9.63 32 182143 3262 46500625
Cyst 10.04 9.63 20 182155 12080 46491807
Stress ulcer 10.02 9.63 5 182170 62 46503825
Malignant respiratory tract neoplasm 10.02 9.63 5 182170 62 46503825
Anastomotic stenosis 10.01 9.63 8 182167 235 46503652
Haematemesis 9.99 9.63 163 182012 28643 46475244
Rectal perforation 9.99 9.63 10 182165 397 46503490
Pulmonary haemorrhage 9.97 9.63 51 182124 6454 46497433
Product use issue 9.96 9.63 287 181888 94357 46409530
Muscle atrophy 9.94 9.63 48 182127 5936 46497951
Gingivitis ulcerative 9.94 9.63 7 182168 169 46503718
Coeliac disease 9.94 9.63 8 182167 7153 46496734
JC virus granule cell neuronopathy 9.91 9.63 6 182169 111 46503776
Breast pain 9.91 9.63 9 182166 7585 46496302
Hepatic artery thrombosis 9.88 9.63 5 182170 64 46503823
Acute graft versus host disease in intestine 9.88 9.63 21 182154 1674 46502213
Cancer in remission 9.87 9.63 4 182171 29 46503858
Cell-mediated immune deficiency 9.87 9.63 4 182171 29 46503858
Renal amyloidosis 9.86 9.63 6 182169 112 46503775
Scar 9.86 9.63 20 182155 11999 46491888
Bursitis infective 9.84 9.63 17 182158 1160 46502727
Hypertension 9.83 9.63 647 181528 195709 46308178
Haemophilus infection 9.83 9.63 15 182160 922 46502965
CSF protein increased 9.82 9.63 11 182164 498 46503389
Congenital ectopic bladder 9.81 9.63 5 182170 65 46503822
Hypertrichosis 9.79 9.63 15 182160 925 46502962
Cerebral venous thrombosis 9.78 9.63 24 182151 2103 46501784
Splenic infarction 9.77 9.63 20 182155 1552 46502335
Bacteriuria 9.77 9.63 13 182162 704 46503183
Emphysematous pyelonephritis 9.76 9.63 7 182168 174 46503713
Histamine intolerance 9.76 9.63 4 182171 30 46503857
Oesophageal ulcer haemorrhage 9.75 9.63 10 182165 409 46503478
Chorioretinal atrophy 9.74 9.63 5 182170 66 46503821
Tibia fracture 9.73 9.63 39 182136 4450 46499437
Psychomotor hyperactivity 9.72 9.63 14 182161 9599 46494288
Pemphigoid 9.71 9.63 46 182129 5645 46498242
Thrombocytosis 9.71 9.63 42 182133 4960 46498927
Streptococcal bacteraemia 9.68 9.63 18 182157 1301 46502586
Renal tubular acidosis 9.68 9.63 20 182155 1563 46502324
Tooth development disorder 9.65 9.63 4 182171 31 46503856
Dependence on respirator 9.65 9.63 4 182171 31 46503856
Poikilocytosis 9.64 9.63 6 182169 117 46503770

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 812.84 10.51 810 161385 22864 29767419
Pneumocystis jirovecii pneumonia 790.83 10.51 691 161504 16429 29773854
Product use in unapproved indication 576.26 10.51 1248 160947 72445 29717838
Interstitial lung disease 421.61 10.51 976 161219 59221 29731062
Completed suicide 395.51 10.51 40 162155 99452 29690831
Death 393.43 10.51 845 161350 356438 29433845
Post transplant lymphoproliferative disorder 372.82 10.51 274 161921 5032 29785251
Hepatitis B 365.73 10.51 286 161909 5786 29784497
Drug abuse 350.92 10.51 24 162171 82048 29708235
Product dose omission issue 325.25 10.51 53 162142 91578 29698705
Fatigue 316.09 10.51 804 161391 319869 29470414
Transplant rejection 302.94 10.51 308 161887 8898 29781385
Epstein-Barr virus infection 288.28 10.51 260 161935 6446 29783837
Polyomavirus-associated nephropathy 238.60 10.51 171 162024 3014 29787269
Strongyloidiasis 238.03 10.51 152 162043 2194 29788089
Diffuse large B-cell lymphoma 237.60 10.51 251 161944 7590 29782693
Nocardiosis 221.73 10.51 169 162026 3286 29786997
Kidney transplant rejection 218.04 10.51 235 161960 7274 29783009
Hepatitis E 217.70 10.51 126 162069 1506 29788777
Fall 212.21 10.51 415 161780 181457 29608826
Bronchopulmonary aspergillosis 208.11 10.51 293 161902 11991 29778292
Nausea 198.58 10.51 881 161314 296076 29494207
Haemophagocytic lymphohistiocytosis 193.95 10.51 252 161943 9539 29780744
Hepatitis B reactivation 189.65 10.51 143 162052 2734 29787549
Aspergillus infection 184.07 10.51 251 161944 9963 29780320
Toxicity to various agents 182.81 10.51 433 161762 176750 29613533
Pyrexia 182.39 10.51 2411 159784 292078 29498205
Lymphoproliferative disorder 181.23 10.51 128 162067 2202 29788081
Complications of transplanted kidney 176.25 10.51 159 162036 3942 29786341
Hypotension 173.92 10.51 534 161661 200031 29590252
Anxiety 173.85 10.51 139 162056 89732 29700551
Asthenia 172.12 10.51 618 161577 220672 29569611
Dizziness 168.95 10.51 519 161676 194390 29595893
Transplant dysfunction 168.71 10.51 123 162072 2229 29788054
Overdose 167.49 10.51 127 162068 84210 29706073
Cardiac failure congestive 165.22 10.51 129 162066 84278 29706005
Hepatic function abnormal 164.75 10.51 551 161644 41394 29748889
Acquired gene mutation 163.86 10.51 93 162102 1068 29789215
Osteonecrosis 163.81 10.51 305 161890 15830 29774453
BK virus infection 154.60 10.51 152 162043 4212 29786071
Disseminated intravascular coagulation 152.28 10.51 357 161838 21814 29768469
Polyomavirus viraemia 149.18 10.51 67 162128 445 29789838
Epstein-Barr virus associated lymphoproliferative disorder 148.66 10.51 101 162094 1627 29788656
Disease recurrence 136.70 10.51 262 161933 13899 29776384
Hypogammaglobulinaemia 131.25 10.51 152 162043 5100 29785183
Feeling abnormal 131.02 10.51 72 162123 56684 29733599
Cryptococcosis 130.98 10.51 95 162100 1707 29788576
Cytomegalovirus viraemia 130.28 10.51 158 162037 5571 29784712
Myocardial infarction 127.85 10.51 309 161886 125316 29664967
Chorioretinopathy 125.23 10.51 85 162110 1367 29788916
Renal impairment 124.87 10.51 832 161363 83352 29706931
Posterior reversible encephalopathy syndrome 124.82 10.51 192 162003 8515 29781768
Progressive multifocal leukoencephalopathy 123.98 10.51 195 162000 8818 29781465
Steroid diabetes 122.57 10.51 80 162115 1201 29789082
Pain 119.44 10.51 505 161690 172136 29618147
Mucormycosis 119.32 10.51 145 162050 5123 29785160
Intentional overdose 119.21 10.51 38 162157 41443 29748840
Depression 119.16 10.51 191 162004 90246 29700037
Immunosuppressant drug level increased 119.04 10.51 137 162058 4565 29785718
Pulmonary tuberculosis 118.76 10.51 139 162056 4718 29785565
Graft versus host disease 118.57 10.51 204 161991 9946 29780337
Cerebrovascular accident 113.11 10.51 173 162022 83304 29706979
Cytomegalovirus colitis 111.73 10.51 97 162098 2282 29788001
Sepsis 111.73 10.51 1248 160947 145147 29645136
Neutropenic sepsis 111.25 10.51 212 161983 11197 29779086
Cytomegalovirus test positive 109.21 10.51 116 162079 3529 29786754
Viraemia 108.84 10.51 72 162123 1107 29789176
Somnolence 107.37 10.51 227 161968 96536 29693747
Adenovirus infection 105.78 10.51 123 162072 4145 29786138
Insomnia 105.21 10.51 217 161978 93119 29697164
Pneumonia bacterial 102.08 10.51 183 162012 9220 29781063
General physical health deterioration 101.39 10.51 904 161291 99040 29691243
Confusional state 100.40 10.51 383 161812 134451 29655832
Nephrotic syndrome 100.35 10.51 153 162042 6732 29783551
Drug hypersensitivity 98.71 10.51 136 162059 68383 29721900
Cushingoid 98.27 10.51 92 162103 2395 29787888
Phaeohyphomycosis 98.20 10.51 59 162136 759 29789524
Headache 97.65 10.51 583 161612 181723 29608560
Bradycardia 97.50 10.51 127 162068 65399 29724884
Osteonecrosis of jaw 93.94 10.51 267 161928 18351 29771932
Peripheral swelling 93.33 10.51 116 162079 60958 29729325
Hospitalisation 92.83 10.51 63 162132 44256 29746027
Idiopathic pulmonary fibrosis 92.16 10.51 112 162083 3957 29786326
Multiple organ dysfunction syndrome 92.01 10.51 624 161571 62863 29727420
Agitation 90.99 10.51 95 162100 53978 29736305
Leukopenia 89.93 10.51 566 161629 55593 29734690
Febrile neutropenia 88.95 10.51 926 161269 105767 29684516
Wrong technique in product usage process 88.70 10.51 29 162166 31126 29759157
Pulmonary nocardiosis 87.77 10.51 43 162152 356 29789927
Disseminated tuberculosis 87.39 10.51 80 162115 2022 29788261
Muscle spasms 87.21 10.51 135 162060 64703 29725580
Blood pressure increased 86.42 10.51 161 162034 71767 29718516
C-reactive protein increased 85.74 10.51 463 161732 43010 29747273
Respiratory failure 85.56 10.51 877 161318 99765 29690518
Thrombotic microangiopathy 85.19 10.51 161 162034 8449 29781834
Injection site pain 84.92 10.51 29 162166 30281 29760002
Chronic graft versus host disease 84.68 10.51 108 162087 4011 29786272
Herpes zoster 84.67 10.51 354 161841 29589 29760694
Disseminated cryptococcosis 84.49 10.51 58 162137 951 29789332
JC virus infection 84.10 10.51 73 162122 1717 29788566
Herpes simplex 83.92 10.51 112 162083 4352 29785931
Brain abscess 83.31 10.51 87 162108 2594 29787689
Cytomegalovirus infection reactivation 82.72 10.51 71 162124 1644 29788639
Liver disorder 82.18 10.51 349 161846 29373 29760910
Unevaluable event 81.43 10.51 35 162160 31750 29758533
Suicide attempt 81.18 10.51 49 162146 36648 29753635
Pneumonia cytomegaloviral 80.28 10.51 87 162108 2709 29787574
Constipation 80.01 10.51 327 161868 112579 29677704
Transplant failure 79.14 10.51 82 162113 2422 29787861
B-cell lymphoma 77.00 10.51 108 162087 4402 29785881
Mental status changes 75.94 10.51 54 162141 37025 29753258
Cytomegalovirus chorioretinitis 74.09 10.51 90 162105 3178 29787105
Colitis ulcerative 73.80 10.51 208 161987 14226 29776057
Epstein-Barr virus infection reactivation 73.75 10.51 33 162162 217 29790066
Intentional product misuse 72.97 10.51 49 162146 34618 29755665
Pneumatosis intestinalis 72.55 10.51 81 162114 2609 29787674
Neuroleptic malignant syndrome 71.89 10.51 4 162191 16291 29773992
Immunosuppression 71.22 10.51 112 162083 5063 29785220
Blood glucose increased 71.05 10.51 141 162054 61389 29728894
Lower respiratory tract infection 71.02 10.51 310 161885 26404 29763879
International normalised ratio increased 70.52 10.51 93 162102 47646 29742637
Mycobacterial infection 68.64 10.51 64 162131 1657 29788626
Blood lactate dehydrogenase increased 68.27 10.51 256 161939 20345 29769938
Plasma cell myeloma 67.50 10.51 116 162079 53346 29736937
Upper respiratory tract inflammation 67.15 10.51 65 162130 1766 29788517
Gait disturbance 66.84 10.51 196 161999 74581 29715702
Infection reactivation 66.50 10.51 49 162146 903 29789380
Acinetobacter infection 66.12 10.51 50 162145 960 29789323
Pneumocystis jirovecii infection 65.52 10.51 56 162139 1289 29788994
Weight increased 65.06 10.51 199 161996 74714 29715569
Electrocardiogram QT prolonged 64.86 10.51 59 162136 35776 29754507
Weight decreased 64.72 10.51 515 161680 150406 29639877
Varicella zoster virus infection 64.24 10.51 54 162141 1214 29789069
Pneumothorax 63.78 10.51 213 161982 15980 29774303
Pain in extremity 63.50 10.51 344 161851 109877 29680406
Dehydration 63.49 10.51 400 161795 123139 29667144
Pneumomediastinum 62.73 10.51 62 162133 1729 29788554
Obliterative bronchiolitis 62.73 10.51 52 162143 1146 29789137
Atypical mycobacterial infection 62.44 10.51 44 162151 754 29789529
Blood pressure fluctuation 62.31 10.51 10 162185 17493 29772790
Diabetes mellitus 62.13 10.51 414 161781 41451 29748832
Hyperhidrosis 62.06 10.51 173 162022 66917 29723366
Neutropenia 61.99 10.51 1009 161186 127531 29662752
Acute respiratory distress syndrome 61.35 10.51 271 161924 23201 29767082
Bone marrow failure 61.30 10.51 321 161874 29464 29760819
Pancytopenia 60.69 10.51 716 161479 84336 29705947
Chronic allograft nephropathy 59.78 10.51 50 162145 1116 29789167
Trichophytosis 58.55 10.51 30 162165 276 29790007
Cardiac arrest 58.45 10.51 281 161914 92569 29697714
COVID-19 58.27 10.51 221 161974 17657 29772626
Diffuse large B-cell lymphoma recurrent 58.16 10.51 64 162131 2028 29788255
Cytomegalovirus enterocolitis 58.15 10.51 43 162152 797 29789486
Lymphopenia 58.06 10.51 180 162015 12983 29777300
Osteoporosis 57.82 10.51 157 162038 10506 29779777
Tremor 57.37 10.51 212 161983 75151 29715132
Amnesia 57.35 10.51 30 162165 24291 29765992
Aggression 56.47 10.51 70 162125 36837 29753446
Renal transplant failure 55.82 10.51 46 162149 1005 29789278
Memory impairment 55.33 10.51 72 162123 37102 29753181
Pyoderma gangrenosum 55.14 10.51 46 162149 1023 29789260
Muscle abscess 55.06 10.51 34 162161 461 29789822
Balance disorder 55.02 10.51 70 162125 36423 29753860
Dermoid cyst 54.93 10.51 22 162173 105 29790178
Type 2 lepra reaction 54.62 10.51 31 162164 356 29789927
Cardio-respiratory arrest 54.32 10.51 146 162049 57160 29733123
Product quality issue 54.28 10.51 17 162178 18757 29771526
Septic shock 53.86 10.51 554 161641 63053 29727230
Acute kidney injury 53.59 10.51 1104 161091 272738 29517545
Hepatic failure 53.16 10.51 341 161854 33702 29756581
Heart transplant rejection 52.70 10.51 48 162147 1205 29789078
Immunosuppressant drug level decreased 52.50 10.51 48 162147 1211 29789072
Heart rate decreased 52.38 10.51 24 162171 20970 29769313
Basal cell carcinoma 51.85 10.51 198 161997 15870 29774413
Candida infection 51.81 10.51 192 162003 15170 29775113
Loss of personal independence in daily activities 51.62 10.51 26 162169 21509 29768774
Full blood count decreased 51.62 10.51 11 162184 15706 29774577
Fungal endocarditis 51.30 10.51 23 162172 152 29790131
Back pain 51.25 10.51 335 161860 102261 29688022
Lymphoma 50.91 10.51 145 162050 9976 29780307
Substance-induced psychotic disorder 50.87 10.51 49 162146 1323 29788960
Heart rate increased 50.74 10.51 82 162113 38639 29751644
Liver transplant rejection 50.59 10.51 61 162134 2137 29788146
Organising pneumonia 50.34 10.51 95 162100 4979 29785304
Lung abscess 50.30 10.51 65 162130 2446 29787837
Visceral leishmaniasis 49.98 10.51 32 162163 464 29789819
Infection 49.96 10.51 644 161551 77430 29712853
Intentional self-injury 49.85 10.51 7 162188 13525 29776758
Sweat gland tumour 49.20 10.51 30 162165 397 29789886
Cardiac disorder 49.05 10.51 88 162107 39805 29750478
Acute graft versus host disease 48.80 10.51 102 162093 5762 29784521
Lymphocele 48.30 10.51 49 162146 1411 29788872
Staphylococcal sepsis 47.76 10.51 136 162059 9355 29780928
Pneumonia 47.75 10.51 2239 159956 332067 29458216
Fungal infection 47.57 10.51 172 162023 13428 29776855
Unresponsive to stimuli 47.21 10.51 44 162151 26375 29763908
Therapy cessation 46.93 10.51 12 162183 15125 29775158
Pseudomonas infection 46.84 10.51 144 162051 10338 29779945
Angiocentric lymphoma 46.30 10.51 26 162169 292 29789991
Drug withdrawal syndrome 45.88 10.51 25 162170 19784 29770499
Abdominal discomfort 45.71 10.51 125 162070 48666 29741617
Pneumonia cryptococcal 45.46 10.51 35 162160 691 29789592
Sedation 45.28 10.51 16 162179 16357 29773926
Suicidal ideation 45.00 10.51 79 162116 36035 29754248
Proteinuria 44.94 10.51 190 162005 15955 29774328
Stress 44.77 10.51 27 162168 20208 29770075
Scleroderma renal crisis 44.76 10.51 18 162177 87 29790196
Pleurisy 44.69 10.51 86 162109 4574 29785709
Varicella 44.61 10.51 48 162147 1482 29788801
Systemic mycosis 44.28 10.51 43 162152 1173 29789110
Drug resistance 44.22 10.51 221 161974 19912 29770371
Contusion 44.11 10.51 63 162132 31217 29759066
Retinal drusen 43.83 10.51 11 162184 3 29790280
Parvovirus B19 infection 43.60 10.51 31 162164 539 29789744
Psoriasis 43.60 10.51 104 162091 42402 29747881
Seizure 43.58 10.51 333 161862 98142 29692141
Syncope 43.53 10.51 275 161920 84628 29705655
Pulmonary fibrosis 43.46 10.51 186 162009 15704 29774579
Condition aggravated 43.25 10.51 1014 161181 136852 29653431
Meningitis cryptococcal 43.08 10.51 54 162141 1970 29788313
Intestinal perforation 42.80 10.51 122 162073 8397 29781886
Human herpesvirus 8 infection 42.67 10.51 33 162162 656 29789627
Incorrect dose administered 42.56 10.51 66 162129 31620 29758663
Enterococcal infection 42.51 10.51 119 162076 8105 29782178
Pneumonia fungal 42.31 10.51 93 162102 5440 29784843
Loss of consciousness 42.30 10.51 254 161941 79121 29711162
Respiratory arrest 42.18 10.51 58 162137 29200 29761083
Nephropathy toxic 41.94 10.51 140 162055 10499 29779784
Cerebral venous thrombosis 41.85 10.51 31 162164 576 29789707
Coronary artery disease 41.77 10.51 134 162061 49578 29740705
Vasculitis 41.68 10.51 116 162079 7874 29782409
Hallucination 41.39 10.51 132 162063 48927 29741356
Vomiting 41.25 10.51 892 161303 218926 29571357
Lactic acidosis 40.99 10.51 66 162129 31147 29759136
Chest pain 40.95 10.51 423 161772 117204 29673079
Intestinal tuberculosis 40.88 10.51 16 162179 71 29790212
Cystitis haemorrhagic 40.69 10.51 84 162111 4703 29785580
Graft versus host disease in skin 40.65 10.51 68 162127 3239 29787044
Escherichia infection 40.59 10.51 100 162095 6305 29783978
Kaposi's sarcoma 40.56 10.51 38 162157 990 29789293
Cerebral aspergillosis 40.30 10.51 43 162152 1315 29788968
Encephalitis 40.27 10.51 100 162095 6336 29783947
Tumour lysis syndrome 40.12 10.51 157 162038 12728 29777555
Inappropriate schedule of product administration 40.12 10.51 98 162097 39630 29750653
Osteoporotic fracture 40.09 10.51 38 162157 1005 29789278
Atypical femur fracture 40.06 10.51 24 162171 307 29789976
Paraesthesia 39.92 10.51 155 162040 54172 29736111
Pulmonary alveolar haemorrhage 39.87 10.51 101 162094 6480 29783803
Off label use 39.77 10.51 1689 160506 247601 29542682
Human herpesvirus 6 infection 39.71 10.51 51 162144 1907 29788376
Sinusitis 39.71 10.51 75 162120 33270 29757013
Alveolar proteinosis 39.65 10.51 23 162172 276 29790007
Pneumonitis 39.23 10.51 269 161926 27185 29763098
Listeria sepsis 39.23 10.51 19 162176 153 29790130
Injection site erythema 39.16 10.51 13 162182 13821 29776462
Arthralgia 38.87 10.51 510 161685 135281 29655002
Therapeutic product effect decreased 38.64 10.51 61 162134 29015 29761268
Nasopharyngitis 38.25 10.51 176 162019 58673 29731610
Bronchiectasis 38.14 10.51 86 162109 5118 29785165
Subcutaneous abscess 38.10 10.51 68 162127 3413 29786870
Lymphocytic infiltration 38.08 10.51 29 162166 563 29789720
Bacterial infection 37.94 10.51 152 162043 12458 29777825
Foetal growth restriction 37.92 10.51 69 162126 3516 29786767
Autoimmune neutropenia 37.58 10.51 22 162173 269 29790014
Poisoning 37.31 10.51 8 162187 11374 29778909
Tuberculosis 37.07 10.51 112 162083 7965 29782318
Peripheral T-cell lymphoma unspecified stage IV 37.00 10.51 12 162183 26 29790257
Neutrophil count decreased 36.99 10.51 372 161823 42082 29748201
Acute graft versus host disease in skin 36.94 10.51 78 162117 4438 29785845
Keratitis 36.68 10.51 38 162157 1122 29789161
Epidural lipomatosis 36.29 10.51 20 162175 216 29790067
Delayed graft function 36.17 10.51 46 162149 1703 29788580
Focal segmental glomerulosclerosis 36.14 10.51 47 162148 1780 29788503
Infective aneurysm 36.06 10.51 24 162171 373 29789910
Intensive care unit acquired weakness 35.89 10.51 33 162162 839 29789444
Musculoskeletal stiffness 35.85 10.51 89 162106 35792 29754491
Small intestinal perforation 35.64 10.51 45 162150 1654 29788629
Tubulointerstitial nephritis 35.56 10.51 191 162004 17700 29772583
Accidental exposure to product 35.51 10.51 6 162189 10109 29780174
Low birth weight baby 35.51 10.51 92 162103 5984 29784299
Trichophytic granuloma 35.44 10.51 14 162181 64 29790219
Drug intolerance 35.38 10.51 126 162069 45165 29745118
Thrombosis 35.36 10.51 114 162081 42117 29748166
Myelodysplastic syndrome 34.99 10.51 197 161998 18581 29771702
Necrotising retinitis 34.94 10.51 30 162165 695 29789588
Epistaxis 34.70 10.51 158 162037 52823 29737460
Steroid withdrawal syndrome 34.57 10.51 19 162176 204 29790079
Gallbladder rupture 34.57 10.51 26 162169 495 29789788
Pruritus 34.54 10.51 442 161753 117762 29672521
Ileal ulcer 34.35 10.51 27 162168 550 29789733
Disseminated varicella zoster virus infection 34.34 10.51 34 162161 950 29789333
Blood beta-D-glucan increased 34.33 10.51 25 162170 452 29789831
Henoch-Schonlein purpura 34.01 10.51 41 162154 1436 29788847
Subcutaneous emphysema 33.97 10.51 34 162161 963 29789320
Adrenal insufficiency 33.81 10.51 129 162066 10334 29779949
Infectious pleural effusion 33.75 10.51 48 162147 1982 29788301
Hypoalbuminaemia 33.61 10.51 134 162061 10958 29779325
Emotional distress 33.55 10.51 22 162173 15743 29774540
Gastric disorder 33.38 10.51 8 162187 10535 29779748
Adverse drug reaction 33.24 10.51 46 162149 23099 29767184
Orthostatic hypotension 33.12 10.51 49 162146 23930 29766353
Gastrointestinal perforation 32.58 10.51 65 162130 3551 29786732
Oesophageal candidiasis 32.46 10.51 71 162124 4139 29786144
Tendon rupture 32.46 10.51 98 162097 6966 29783317
Neuropathy peripheral 32.27 10.51 236 161959 70239 29720044
Presyncope 32.06 10.51 24 162171 16032 29774251
Accidental overdose 31.99 10.51 31 162164 18244 29772039
Diarrhoea 31.89 10.51 1482 160713 332621 29457662
Infective spondylitis 31.71 10.51 17 162178 173 29790110
Keratitis bacterial 31.65 10.51 13 162182 67 29790216
Pyelonephritis acute 31.54 10.51 41 162154 1552 29788731
Human polyomavirus infection 31.53 10.51 27 162168 623 29789660
Hepatitis infectious mononucleosis 31.39 10.51 11 162184 33 29790250
Hypersomnia 31.39 10.51 11 162184 11305 29778978
Epstein-Barr virus associated lymphoma 31.17 10.51 25 162170 525 29789758
Burning sensation 31.17 10.51 26 162169 16448 29773835
Road traffic accident 31.01 10.51 28 162167 17043 29773240
Atrial fibrillation 30.96 10.51 406 161789 107718 29682565
Blood pressure systolic increased 30.94 10.51 22 162173 15088 29775195
Head injury 30.82 10.51 28 162167 16992 29773291
Coma 30.62 10.51 114 162081 40335 29749948
Hypofibrinogenaemia 30.50 10.51 41 162154 1604 29788679
Hypoglycaemia 30.50 10.51 157 162038 50824 29739459
Flushing 30.37 10.51 72 162123 29420 29760863
Corneal lesion 30.04 10.51 9 162186 13 29790270
Ocular procedural complication 30.01 10.51 12 162183 57 29790226
Graft versus host disease in gastrointestinal tract 29.88 10.51 57 162138 3012 29787271
Epstein Barr virus positive mucocutaneous ulcer 29.86 10.51 18 162177 233 29790050
Growth retardation 29.86 10.51 40 162155 1560 29788723
Lung infiltration 29.83 10.51 141 162054 12418 29777865
Nasal congestion 29.69 10.51 34 162161 18532 29771751
Epstein-Barr virus test positive 29.49 10.51 24 162171 515 29789768
Tonsillitis 29.47 10.51 45 162150 1982 29788301
Serotonin syndrome 29.45 10.51 32 162163 17859 29772424
Fluid overload 29.42 10.51 36 162159 19056 29771227
Cholangitis 29.29 10.51 101 162094 7701 29782582
Injection site swelling 29.13 10.51 6 162189 8774 29781509
Uveitis 29.05 10.51 80 162115 5397 29784886
Pyelonephritis chronic 29.04 10.51 10 162185 28 29790255
Agranulocytosis 29.01 10.51 211 161984 21731 29768552
Dry skin 28.99 10.51 48 162147 22406 29767877
Pneumonia viral 28.92 10.51 52 162143 2625 29787658
Adult T-cell lymphoma/leukaemia 28.90 10.51 18 162177 248 29790035
Urosepsis 28.87 10.51 125 162070 10607 29779676
Haemorrhage subcutaneous 28.84 10.51 47 162148 2190 29788093
Dyskinesia 28.82 10.51 46 162149 21788 29768495
Migraine 28.73 10.51 17 162178 12857 29777426
Miosis 28.70 10.51 4 162191 7772 29782511
Vision blurred 28.41 10.51 123 162072 41693 29748590
Peritonitis bacterial 28.39 10.51 13 162182 11365 29778918
Oesophageal carcinoma 28.19 10.51 57 162138 3144 29787139
Dyspepsia 28.18 10.51 78 162117 30251 29760032
Central nervous system lymphoma 28.14 10.51 29 162166 851 29789432
Hepatosplenomegaly 28.07 10.51 62 162133 3639 29786644
Skin necrosis 28.07 10.51 72 162123 4655 29785628
Blood creatine phosphokinase increased 27.98 10.51 132 162063 43716 29746567
Amoebic colitis 27.83 10.51 10 162185 33 29790250
Influenza like illness 27.59 10.51 61 162134 25544 29764739
Injury 27.56 10.51 47 162148 21684 29768599
Trichosporon infection 27.43 10.51 25 162170 628 29789655
Joint swelling 27.28 10.51 146 162049 46800 29743483
Chest discomfort 27.24 10.51 140 162055 45340 29744943
Second primary malignancy 27.18 10.51 86 162109 6270 29784013
Mycobacterium chelonae infection 27.07 10.51 24 162171 581 29789702
Endocarditis 26.98 10.51 83 162112 5960 29784323
Large intestine perforation 26.96 10.51 97 162098 7554 29782729
Actinic keratosis 26.92 10.51 60 162135 3543 29786740
Polyomavirus test positive 26.81 10.51 13 162182 105 29790178
Blood glucose decreased 26.73 10.51 19 162176 13034 29777249
Splenic abscess 26.70 10.51 18 162177 286 29789997
Myelitis 26.57 10.51 25 162170 655 29789628
Opportunistic infection 26.50 10.51 34 162161 1270 29789013
Cytomegalovirus enteritis 26.45 10.51 20 162175 384 29789899
T-cell lymphoma stage IV 26.41 10.51 14 162181 139 29790144
Herpes zoster meningoencephalitis 26.40 10.51 17 162178 249 29790034
Gastrooesophageal reflux disease 26.36 10.51 88 162107 32167 29758116
Bacterial sepsis 26.17 10.51 72 162123 4854 29785429
Ageusia 26.07 10.51 8 162187 8945 29781338
Abnormal behaviour 26.03 10.51 63 162132 25560 29764723
Alternaria infection 26.02 10.51 18 162177 299 29789984
Lupus nephritis 25.89 10.51 17 162178 258 29790025
Cutaneous T-cell lymphoma 25.87 10.51 34 162161 1301 29788982
Rhabdomyolysis 25.81 10.51 220 161975 63360 29726923
Meningitis listeria 25.79 10.51 19 162176 350 29789933
Corneal deposits 25.79 10.51 15 162180 181 29790102
Dermatophytosis 25.78 10.51 16 162179 219 29790064
Body temperature decreased 25.75 10.51 10 162185 9645 29780638
Retinal pigment epitheliopathy 25.72 10.51 16 162179 220 29790063
Lung transplant rejection 25.70 10.51 26 162169 746 29789537
Nervousness 25.70 10.51 16 162179 11772 29778511
Mycobacterium abscessus infection 25.66 10.51 23 162172 565 29789718
Gastroenteritis adenovirus 25.61 10.51 12 162183 89 29790194
Cutaneous tuberculosis 25.61 10.51 12 162183 89 29790194
Pneumothorax spontaneous 25.59 10.51 20 162175 404 29789879
Oral herpes 25.57 10.51 67 162128 4388 29785895
Rash 25.55 10.51 818 161377 191071 29599212
Gamma-glutamyltransferase increased 25.48 10.51 257 161938 29093 29761190
Lymphadenopathy 25.44 10.51 222 161973 24154 29766129
Tuberculous pleurisy 25.34 10.51 19 162176 360 29789923
Large intestinal ulcer 25.32 10.51 38 162157 1648 29788635
Rhinorrhoea 25.31 10.51 46 162149 20708 29769575
Glomerulonephritis membranous 25.19 10.51 30 162165 1037 29789246
Pseudomembranous colitis 25.18 10.51 51 162144 2817 29787466
Factitious disorder 25.09 10.51 10 162185 47 29790236
Neck pain 25.03 10.51 47 162148 20897 29769386
Squamous cell carcinoma 25.02 10.51 116 162079 10134 29780149
Erectile dysfunction 24.99 10.51 37 162158 18065 29772218
Therapy partial responder 24.86 10.51 59 162136 3632 29786651
Gingival hypertrophy 24.80 10.51 37 162158 1596 29788687
Infection in an immunocompromised host 24.79 10.51 24 162171 652 29789631
Glomerulonephritis membranoproliferative 24.60 10.51 19 162176 377 29789906
Fear 24.58 10.51 14 162181 10811 29779472
Cytomegalovirus gastroenteritis 24.57 10.51 15 162180 199 29790084
Myopathy 24.53 10.51 118 162077 10468 29779815
Malacoplakia gastrointestinal 24.50 10.51 11 162184 73 29790210
Peliosis hepatis 24.43 10.51 10 162185 51 29790232
Autoimmune haemolytic anaemia 24.28 10.51 62 162133 3997 29786286
Pemphigus 24.26 10.51 32 162163 1229 29789054
Dry mouth 24.16 10.51 55 162140 22795 29767488
Systemic candida 24.08 10.51 49 162146 2715 29787568
Enterovesical fistula 24.03 10.51 23 162172 616 29789667
Endocarditis bacterial 24.00 10.51 26 162169 809 29789474
Inferior vena cava stenosis 23.88 10.51 8 162187 20 29790263
Angiosarcoma 23.80 10.51 16 162179 253 29790030
Squamous cell carcinoma of skin 23.75 10.51 105 162090 8990 29781293
Mycetoma mycotic 23.73 10.51 9 162186 36 29790247
Tubulointerstitial nephritis and uveitis syndrome 23.73 10.51 9 162186 36 29790247
Gastritis bacterial 23.51 10.51 14 162181 177 29790106
Pouchitis 23.49 10.51 23 162172 634 29789649
Salivary hypersecretion 23.45 10.51 6 162189 7560 29782723
Medication error 23.39 10.51 49 162146 20923 29769360
Diffuse large B-cell lymphoma stage III 23.24 10.51 10 162185 59 29790224
Molluscum contagiosum 23.22 10.51 16 162179 264 29790019
Infertility 23.18 10.51 14 162181 182 29790101
Underdose 23.17 10.51 19 162176 12122 29778161
Graft loss 23.13 10.51 26 162169 844 29789439
Central nervous system infection 23.12 10.51 20 162175 468 29789815
B-cell lymphoma refractory 23.09 10.51 12 162183 114 29790169
Colitis 23.08 10.51 262 161933 30558 29759725
Gastric cancer 23.05 10.51 69 162126 4881 29785402
B-lymphocyte count decreased 23.05 10.51 20 162175 470 29789813
Chronic inflammatory demyelinating polyradiculoneuropathy 22.93 10.51 22 162173 591 29789692
Epstein-Barr virus antibody positive 22.90 10.51 17 162178 317 29789966
Blood pressure decreased 22.83 10.51 155 162040 46920 29743363
Endophthalmitis 22.76 10.51 55 162140 3425 29786858
Polychondritis 22.70 10.51 13 162182 152 29790131
Acute hepatic failure 22.65 10.51 125 162070 11702 29778581
Arthropathy 22.64 10.51 49 162146 20678 29769605
Gastroenteritis norovirus 22.55 10.51 33 162162 1399 29788884
Sphincter of Oddi dysfunction 22.48 10.51 12 162183 121 29790162
Granulomatosis with polyangiitis 22.38 10.51 26 162169 875 29789408
Device malfunction 22.30 10.51 8 162187 8103 29782180
Muscle rigidity 22.27 10.51 14 162181 10247 29780036
Pulpitis dental 22.05 10.51 18 162177 388 29789895
IVth nerve paralysis 21.97 10.51 9 162186 46 29790237
Sleep disorder 21.97 10.51 64 162131 24415 29765868
Pustular psoriasis 21.96 10.51 35 162160 1600 29788683
Hyperglycaemia 21.92 10.51 289 161906 34911 29755372
Scedosporium infection 21.85 10.51 23 162172 692 29789591
Hypoaesthesia 21.85 10.51 188 162007 54042 29736241
Peripheral T-cell lymphoma unspecified 21.80 10.51 20 162175 507 29789776
Ureteric stenosis 21.79 10.51 30 162165 1201 29789082
Extranodal marginal zone B-cell lymphoma (MALT type) 21.79 10.51 13 162182 165 29790118
Rebound effect 21.78 10.51 34 162161 1527 29788756
Parvovirus infection 21.67 10.51 19 162176 453 29789830
Enterococcal sepsis 21.66 10.51 34 162161 1534 29788749
Paresis 21.54 10.51 37 162158 1801 29788482
Arthritis bacterial 21.53 10.51 63 162132 4401 29785882
Cerebral infarction 21.50 10.51 228 161967 26145 29764138
Pulmonary air leakage 21.48 10.51 11 162184 101 29790182
Pancreas transplant rejection 21.39 10.51 13 162182 171 29790112
Plasmablastic lymphoma 21.39 10.51 15 162180 255 29790028
Hepatitis fulminant 21.34 10.51 58 162137 3883 29786400
Cell marker increased 21.33 10.51 19 162176 463 29789820
Blood count abnormal 21.30 10.51 19 162176 11633 29778650
Mediastinal abscess 21.29 10.51 8 162187 31 29790252
Heart rate irregular 21.22 10.51 21 162174 12238 29778045
Herpes simplex test positive 21.13 10.51 13 162182 175 29790108
Pneumonia pneumococcal 21.12 10.51 37 162158 1830 29788453
Spinal compression fracture 21.09 10.51 78 162117 6156 29784127
Atypical pneumonia 21.07 10.51 46 162149 2678 29787605
Rash pruritic 21.01 10.51 58 162137 22514 29767769
Complications of transplanted lung 20.94 10.51 13 162182 178 29790105
Skin striae 20.93 10.51 18 162177 418 29789865
Enterobacter infection 20.89 10.51 39 162156 2027 29788256
Toxoplasmosis 20.89 10.51 27 162168 1016 29789267
Juvenile idiopathic arthritis 20.89 10.51 27 162168 1016 29789267
Irritability 20.88 10.51 60 162135 22990 29767293
Varicella zoster pneumonia 20.80 10.51 9 162186 54 29790229
Encephalitis Japanese B 20.76 10.51 7 162188 18 29790265
Cerebral salt-wasting syndrome 20.71 10.51 8 162187 34 29790249
Kidney fibrosis 20.64 10.51 39 162156 2046 29788237
Subdural haematoma 20.60 10.51 45 162150 18927 29771356
Labelled drug-drug interaction medication error 20.60 10.51 112 162083 10426 29779857
Injection site bruising 20.59 10.51 7 162188 7331 29782952
Treatment noncompliance 20.56 10.51 69 162126 25184 29765099
Oral candidiasis 20.53 10.51 116 162079 10955 29779328
Dermatophytosis of nail 20.53 10.51 8 162187 35 29790248
Complications of transplanted liver 20.53 10.51 14 162181 227 29790056
Lepromatous leprosy 20.39 10.51 10 162185 83 29790200
Granuloma 20.36 10.51 42 162153 2350 29787933
Cystitis escherichia 20.33 10.51 13 162182 188 29790095
Renal adenoma 20.23 10.51 7 162188 20 29790263
Restrictive allograft syndrome 20.23 10.51 7 162188 20 29790263
B-cell lymphoma recurrent 20.22 10.51 21 162174 622 29789661
Exposed bone in jaw 20.21 10.51 36 162159 1804 29788479
Graft versus host disease in liver 20.17 10.51 26 162169 976 29789307
Pyelonephritis 20.16 10.51 70 162125 5356 29784927
Pneumonia acinetobacter 20.14 10.51 9 162186 59 29790224
Gallbladder necrosis 20.14 10.51 9 162186 59 29790224
Cytomegalovirus gastritis 20.10 10.51 13 162182 192 29790091
Hepatic infection fungal 20.06 10.51 12 162183 153 29790130
Hernia 20.06 10.51 11 162184 8675 29781608
Ureteric obstruction 20.04 10.51 29 162166 1217 29789066
Dysgeusia 20.04 10.51 68 162127 24733 29765550
Incorrect route of product administration 20.03 10.51 19 162176 11296 29778987
No adverse event 20.02 10.51 40 162155 17379 29772904
Herpes simplex hepatitis 19.99 10.51 10 162185 87 29790196
Symptom masked 19.99 10.51 18 162177 445 29789838
Scrotal ulcer 19.99 10.51 16 162179 335 29789948
Erythema multiforme 19.96 10.51 91 162104 7894 29782389
Gastroenteritis sapovirus 19.94 10.51 11 162184 119 29790164
Gastroenteritis bacterial 19.89 10.51 9 162186 61 29790222
Escherichia sepsis 19.87 10.51 57 162138 3937 29786346
Haematocrit decreased 19.83 10.51 92 162103 30607 29759676
Tularaemia 19.80 10.51 10 162185 89 29790194
Leukaemic infiltration 19.76 10.51 9 162186 62 29790221
Liver abscess 19.69 10.51 50 162145 3212 29787071
Lymphoplasmacytoid lymphoma/immunocytoma 19.68 10.51 8 162187 40 29790243
Facial paresis 19.67 10.51 46 162149 2804 29787479
Hydrocephalus 19.67 10.51 59 162136 4178 29786105
Renal graft infection 19.52 10.51 14 162181 247 29790036
Cytomegalovirus hepatitis 19.49 10.51 15 162180 296 29789987
Gallbladder disorder 19.48 10.51 4 162191 5863 29784420
Nephrolithiasis 19.39 10.51 69 162126 24741 29765542
H1N1 influenza 19.38 10.51 25 162170 939 29789344
Interleukin level increased 19.36 10.51 8 162187 42 29790241
Xanthogranuloma 19.36 10.51 8 162187 42 29790241
Cutaneous malacoplakia 19.36 10.51 8 162187 42 29790241
Pulmonary vasculitis 19.29 10.51 9 162186 66 29790217
Sinusitis aspergillus 19.29 10.51 9 162186 66 29790217
Laboratory test abnormal 19.24 10.51 41 162154 17401 29772882
Mantle cell lymphoma refractory 19.24 10.51 10 162185 95 29790188
Cutaneous nocardiosis 19.24 10.51 10 162185 95 29790188
Listeriosis 19.22 10.51 24 162171 872 29789411
Bulbar palsy 19.21 10.51 13 162182 208 29790075
Alcohol abuse 19.18 10.51 3 162192 5350 29784933
Sinus bradycardia 19.16 10.51 21 162174 11674 29778609
Glomerulonephritis proliferative 19.15 10.51 13 162182 209 29790074
Injection site reaction 19.13 10.51 18 162177 10742 29779541
Klebsiella infection 19.13 10.51 81 162114 6806 29783477
Abdominal distension 19.07 10.51 157 162038 45552 29744731
Metastases to lymph nodes 19.06 10.51 56 162139 3921 29786362
Acute myocardial infarction 18.97 10.51 189 162006 52750 29737533
Hypersensitivity 18.90 10.51 194 162001 53834 29736449
Genitourinary tract infection 18.80 10.51 10 162185 100 29790183
Adenoviral haemorrhagic cystitis 18.79 10.51 17 162178 423 29789860
Chromoblastomycosis 18.77 10.51 8 162187 46 29790237
Respiratory tract infection 18.74 10.51 146 162049 15360 29774923
Fungal skin infection 18.73 10.51 41 162154 2391 29787892
Cholangitis sclerosing 18.72 10.51 24 162171 896 29789387
Adverse event 18.71 10.51 34 162161 15307 29774976
Cellulitis gangrenous 18.68 10.51 12 162183 175 29790108
Acanthosis 18.63 10.51 9 162186 72 29790211
Anaplastic large-cell lymphoma 18.62 10.51 12 162183 176 29790107
Biopsy kidney abnormal 18.55 10.51 10 162185 103 29790180
Febrile infection 18.55 10.51 33 162162 1652 29788631
Toxic epidermal necrolysis 18.52 10.51 163 162032 17777 29772506
Ileal stenosis 18.51 10.51 27 162168 1141 29789142
Systemic lupus erythematosus 18.47 10.51 42 162153 2514 29787769
Cytomegalovirus gastrointestinal ulcer 18.45 10.51 7 162188 28 29790255
T-cell type acute leukaemia 18.34 10.51 12 162183 181 29790102
Mycoplasma infection 18.33 10.51 14 162181 273 29790010
Product administration error 18.31 10.51 31 162164 14346 29775937
Meningoencephalitis viral 18.30 10.51 10 162185 106 29790177
Acute myeloid leukaemia 18.28 10.51 163 162032 17843 29772440
Autoimmune hepatitis 18.27 10.51 52 162143 3575 29786708
Oxygen saturation decreased 18.22 10.51 149 162046 43291 29746992
Acute interstitial pneumonitis 18.20 10.51 16 162179 383 29789900
Swelling 18.18 10.51 117 162078 35858 29754425
Back disorder 18.11 10.51 5 162190 5989 29784294
Throat irritation 18.09 10.51 12 162183 8536 29781747
Blood triglycerides increased 18.06 10.51 30 162165 13987 29776296
Glomerulonephritis 18.05 10.51 34 162161 1779 29788504
Osteoarthritis 17.94 10.51 46 162149 18303 29771980
Staphylococcal infection 17.93 10.51 246 161949 29978 29760305
Pneumoperitoneum 17.90 10.51 32 162163 1608 29788675
Hemianopia heteronymous 17.89 10.51 7 162188 31 29790252
Cow pox 17.89 10.51 7 162188 31 29790252
Infective tenosynovitis 17.83 10.51 8 162187 53 29790230
Immobilisation syndrome 17.83 10.51 9 162186 80 29790203
Cytomegalovirus oesophagitis 17.81 10.51 13 162182 236 29790047
Psoas abscess 17.81 10.51 19 162176 581 29789702
Extrapyramidal disorder 17.74 10.51 19 162176 10674 29779609
Gas gangrene 17.70 10.51 8 162187 54 29790229
Mycobacterium fortuitum infection 17.68 10.51 12 162183 193 29790090
Argentine haemorrhagic fever 17.64 10.51 6 162189 16 29790267
Serous retinal detachment 17.62 10.51 14 162181 290 29789993
Cytomegalovirus nephritis 17.61 10.51 10 162185 115 29790168
Drug ineffective for unapproved indication 17.60 10.51 110 162085 10770 29779513
Product substitution issue 17.59 10.51 17 162178 10018 29780265
Acute biphenotypic leukaemia 17.58 10.51 8 162187 55 29790228
Abscess fungal 17.57 10.51 11 162184 153 29790130
Neurofibrosarcoma 17.55 10.51 7 162188 33 29790250
Metastatic carcinoma of the bladder 17.53 10.51 10 162185 116 29790167
Dermatomyositis 17.53 10.51 25 162170 1035 29789248
Renal abscess 17.47 10.51 12 162183 197 29790086
Cryptococcal cutaneous infection 17.45 10.51 9 162186 84 29790199
Mantle cell lymphoma recurrent 17.39 10.51 16 162179 407 29789876
Human herpesvirus 6 infection reactivation 17.37 10.51 6 162189 17 29790266
Superior sagittal sinus thrombosis 17.30 10.51 14 162181 298 29789985
Intraocular pressure increased 17.27 10.51 64 162131 5056 29785227
Injection site mass 17.25 10.51 3 162192 4950 29785333
Product complaint 17.25 10.51 5 162190 5801 29784482
Hepatocellular injury 17.25 10.51 75 162120 25396 29764887
Haemoglobin decreased 17.24 10.51 478 161717 113620 29676663
Spindle cell sarcoma 17.18 10.51 9 162186 87 29790196
Gastrointestinal wall thickening 17.15 10.51 23 162172 898 29789385
Urticaria 17.13 10.51 201 161994 54405 29735878
Septic encephalopathy 17.11 10.51 8 162187 59 29790224
Respiratory tract haemorrhage 17.08 10.51 22 162173 825 29789458
Isosporiasis 17.01 10.51 9 162186 89 29790194
Papilloma viral infection 16.96 10.51 15 162180 362 29789921
Pleural effusion 16.94 10.51 523 161672 73543 29716740
Sudden hearing loss 16.94 10.51 22 162173 832 29789451
Alpha tumour necrosis factor increased 16.90 10.51 4 162191 0 29790283
Post herpetic neuralgia 16.87 10.51 24 162171 991 29789292
Polyarteritis nodosa 16.83 10.51 13 162182 258 29790025
Glomerulonephritis rapidly progressive 16.79 10.51 16 162179 426 29789857
Fundoscopy abnormal 16.78 10.51 5 162190 7 29790276
Abdominal pain upper 16.76 10.51 238 161957 62313 29727970
Mobility decreased 16.74 10.51 78 162117 25921 29764362
Sleep apnoea syndrome 16.69 10.51 42 162153 16815 29773468
Scleritis 16.66 10.51 13 162182 262 29790021
Attention-seeking behaviour 16.60 10.51 7 162188 39 29790244
Heart block congenital 16.60 10.51 7 162188 39 29790244
Amoebiasis 16.60 10.51 7 162188 39 29790244
Skin lesion 16.56 10.51 163 162032 18331 29771952
Smooth muscle cell neoplasm 16.51 10.51 9 162186 95 29790188
Product storage error 16.42 10.51 7 162188 6384 29783899
Polyglandular autoimmune syndrome type III 16.39 10.51 5 162190 8 29790275
Concomitant disease aggravated 16.38 10.51 63 162132 5066 29785217
Myelopathy 16.36 10.51 34 162161 1913 29788370
Candida pneumonia 16.33 10.51 13 162182 270 29790013
Meningitis bacterial 16.32 10.51 25 162170 1104 29789179
Intestinal ulcer 16.30 10.51 21 162174 788 29789495
C-reactive protein abnormal 16.28 10.51 5 162190 5588 29784695
Mycobacterium kansasii infection 16.25 10.51 12 162183 222 29790061
Coronary artery occlusion 16.20 10.51 22 162173 11135 29779148
Coronary artery bypass 16.18 10.51 4 162191 5158 29785125
Monocyte percentage decreased 16.17 10.51 7 162188 42 29790241
Skin papilloma 16.17 10.51 31 162164 1644 29788639
Speech disorder 16.10 10.51 73 162122 24439 29765844
Chronic myeloid leukaemia 16.08 10.51 40 162155 2537 29787746
Rheumatoid vasculitis 16.06 10.51 12 162183 226 29790057
Meningitis 16.06 10.51 58 162137 4524 29785759
Pollakiuria 16.06 10.51 43 162152 16863 29773420
Neutrophil morphology abnormal 16.05 10.51 8 162187 69 29790214
Sinusitis fungal 16.04 10.51 15 162180 390 29789893
Retinal detachment 16.03 10.51 62 162133 4998 29785285
Prostate cancer metastatic 15.98 10.51 62 162133 5005 29785278
Blood pressure abnormal 15.96 10.51 9 162186 6990 29783293
Lung consolidation 15.96 10.51 61 162134 4891 29785392
Diarrhoea haemorrhagic 15.91 10.51 68 162127 5737 29784546
Protothecosis 15.91 10.51 7 162188 44 29790239
Pancreatic enzymes increased 15.90 10.51 18 162177 589 29789694
Myasthenia gravis crisis 15.89 10.51 14 162181 336 29789947
Guillain-Barre syndrome 15.88 10.51 62 162133 5021 29785262
Apnoea 15.85 10.51 7 162188 6251 29784032
Engraftment syndrome 15.81 10.51 21 162174 812 29789471
Mediastinitis 15.80 10.51 17 162178 525 29789758
Mycobacterium avium complex infection 15.79 10.51 41 162154 2670 29787613
Lymph node tuberculosis 15.73 10.51 16 162179 462 29789821
Hepatic atrophy 15.73 10.51 11 162184 186 29790097
Dengue fever 15.73 10.51 11 162184 186 29790097
Gallbladder oedema 15.68 10.51 11 162184 187 29790096
Gait inability 15.67 10.51 51 162144 18790 29771493
Retinitis 15.66 10.51 13 162182 287 29789996
Infective pulmonary exacerbation of cystic fibrosis 15.64 10.51 14 162181 8558 29781725
Abdominal tenderness 15.64 10.51 50 162145 3666 29786617
Discomfort 15.63 10.51 34 162161 14322 29775961
Rheumatoid factor 15.58 10.51 8 162187 74 29790209
Eye infection toxoplasmal 15.53 10.51 11 162184 190 29790093
Disseminated strongyloidiasis 15.52 10.51 7 162188 47 29790236
Polymyalgia rheumatica 15.52 10.51 24 162171 1069 29789214
International normalised ratio decreased 15.51 10.51 3 162192 4587 29785696
Moraxella infection 15.50 10.51 12 162183 239 29790044
Herpes zoster oticus 15.48 10.51 8 162187 75 29790208
Transient ischaemic attack 15.41 10.51 77 162118 25123 29765160
Continuous haemodiafiltration 15.39 10.51 24 162171 1077 29789206
Metastasis 15.38 10.51 46 162149 3252 29787031
Serositis 15.33 10.51 10 162185 150 29790133
Nerve conduction studies abnormal 15.28 10.51 7 162188 49 29790234
Necrosis 15.24 10.51 62 162133 5117 29785166
Therapy interrupted 15.22 10.51 3 162192 4526 29785757
Acute monocytic leukaemia 15.19 10.51 14 162181 357 29789926
Impaired healing 15.17 10.51 131 162064 14209 29776074
Cerebral toxoplasmosis 15.15 10.51 28 162167 1444 29788839
Haematochezia 15.12 10.51 265 161930 33957 29756326
Pseudomonal sepsis 15.10 10.51 43 162152 2957 29787326
Schizophrenia 15.09 10.51 16 162179 9032 29781251
Splenic neoplasm malignancy unspecified 15.07 10.51 5 162190 12 29790271
Connective tissue disorder 15.01 10.51 11 162184 201 29790082
Renal failure 15.00 10.51 559 161636 128407 29661876
High-grade B-cell lymphoma 14.99 10.51 10 162185 156 29790127
Non-cirrhotic portal hypertension 14.92 10.51 12 162183 253 29790030
Failure to thrive 14.88 10.51 13 162182 8041 29782242
Drug dependence 14.85 10.51 62 162133 21233 29769050
Hypochromic anaemia 14.85 10.51 20 162175 784 29789499
Mental impairment 14.82 10.51 17 162178 9260 29781023
Phaeohyphomycotic brain abscess 14.76 10.51 6 162189 30 29790253
Intervertebral disc degeneration 14.75 10.51 5 162190 5246 29785037
Substance abuse 14.74 10.51 10 162185 7030 29783253
Autoimmune colitis 14.71 10.51 20 162175 791 29789492
Mesenteric vascular insufficiency 14.71 10.51 7 162188 54 29790229
Spleen atrophy 14.67 10.51 4 162191 3 29790280
Pneumonia mycoplasmal 14.65 10.51 14 162181 374 29789909
Lethargy 14.61 10.51 140 162055 39379 29750904
Aortic aneurysm rupture 14.60 10.51 23 162172 1041 29789242
Fusarium infection 14.60 10.51 23 162172 1041 29789242
Acanthoma 14.60 10.51 6 162189 31 29790252
Haemolytic uraemic syndrome 14.58 10.51 33 162162 1969 29788314
Interleukin-2 receptor increased 14.51 10.51 9 162186 123 29790160
Chorioretinitis 14.51 10.51 10 162185 165 29790118
Ophthalmic herpes zoster 14.50 10.51 18 162177 650 29789633
Adrenocortical insufficiency acute 14.48 10.51 26 162169 1311 29788972
Tinnitus 14.48 10.51 42 162153 16046 29774237
Papillary renal cell carcinoma 14.45 10.51 9 162186 124 29790159
Removal of renal transplant 14.44 10.51 6 162189 32 29790251
VIth nerve paresis 14.44 10.51 6 162189 32 29790251
West Nile viral infection 14.36 10.51 17 162178 584 29789699
Akathisia 14.34 10.51 7 162188 5897 29784386
Multiple sclerosis 14.33 10.51 11 162184 7256 29783027
Hypertension 14.33 10.51 525 161670 120829 29669454
Dystonia 14.30 10.51 19 162176 9708 29780575
Microsporidia infection 14.29 10.51 17 162178 587 29789696
Cytomegalovirus duodenitis 14.28 10.51 7 162188 58 29790225
New onset diabetes after transplantation 14.27 10.51 5 162190 15 29790268
Herpes zoster cutaneous disseminated 14.26 10.51 10 162185 170 29790113
Rheumatoid lung 14.25 10.51 13 162182 327 29789956
Non-alcoholic steatohepatitis 14.24 10.51 19 162176 738 29789545
DNULL antibody positive 14.18 10.51 7 162188 59 29790224
Hypereosinophilic syndrome 14.17 10.51 11 162184 220 29790063
Erythema infectiosum 14.16 10.51 10 162185 172 29790111
Acquired porokeratosis 14.15 10.51 4 162191 4 29790279
Neonatal lupus erythematosus 14.15 10.51 4 162191 4 29790279
Cutaneous T-cell lymphoma recurrent 14.15 10.51 6 162189 34 29790249
Musculoskeletal chest pain 14.14 10.51 17 162178 9068 29781215
Papilloedema 14.11 10.51 36 162159 2320 29787963
Myoclonus 14.10 10.51 32 162163 13280 29777003
Metastases to liver 14.10 10.51 112 162083 11853 29778430
Cerebellar infarction 14.05 10.51 31 162164 1818 29788465
Candida sepsis 14.05 10.51 23 162172 1076 29789207
Retroperitoneal neoplasm 14.03 10.51 5 162190 16 29790267
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 14.03 10.51 5 162190 16 29790267
Platelet count decreased 14.03 10.51 706 161489 105423 29684860
Dental fistula 14.03 10.51 9 162186 131 29790152
Skin erosion 14.01 10.51 30 162165 1723 29788560
Poikiloderma 14.01 10.51 10 162185 175 29790108
Liver transplant failure 14.01 10.51 8 162187 93 29790190
Aplasia pure red cell 13.98 10.51 64 162131 5562 29784721
Abnormal dreams 13.93 10.51 14 162181 8101 29782182
Seroma 13.91 10.51 17 162178 604 29789679
Pneumococcal infection 13.90 10.51 13 162182 338 29789945
Diffuse large B-cell lymphoma stage IV 13.88 10.51 11 162184 227 29790056
Viral cardiomyopathy 13.86 10.51 6 162189 36 29790247
Diffuse large B-cell lymphoma refractory 13.85 10.51 19 162176 758 29789525
Myositis 13.84 10.51 100 162095 10277 29780006
Meningoencephalitis herpetic 13.83 10.51 19 162176 759 29789524
Relapsing fever 13.82 10.51 10 162185 179 29790104
Giant cell arteritis 13.81 10.51 18 162177 683 29789600
Pneumonia legionella 13.79 10.51 28 162167 1549 29788734
Middle insomnia 13.79 10.51 7 162188 5766 29784517
Cardiogenic shock 13.78 10.51 46 162149 16815 29773468
T-cell lymphoma 13.73 10.51 21 162174 926 29789357
N-telopeptide urine increased 13.73 10.51 6 162189 37 29790246
Gastric perforation 13.73 10.51 33 162162 2048 29788235
Skin laceration 13.66 10.51 25 162170 11226 29779057
Coronary arterial stent insertion 13.64 10.51 3 162192 4191 29786092
Rheumatoid factor increased 13.61 10.51 15 162180 476 29789807
Anal abscess 13.60 10.51 59 162136 5010 29785273
Pneumaturia 13.60 10.51 6 162189 38 29790245
Cyclosporidium infection 13.59 10.51 5 162190 18 29790265
Neoplasm skin 13.59 10.51 15 162180 477 29789806
Cognitive disorder 13.58 10.51 74 162121 23616 29766667
Gingival erythema 13.57 10.51 9 162186 139 29790144
Polyneuropathy 13.57 10.51 110 162085 11713 29778570
Small intestinal obstruction 13.54 10.51 34 162161 13625 29776658
Respiratory rate increased 13.54 10.51 17 162178 8898 29781385
Meningitis tuberculous 13.53 10.51 16 162179 549 29789734
Angina unstable 13.53 10.51 29 162166 12281 29778002
Peritonitis 13.52 10.51 176 162019 21199 29769084
Viral load increased 13.50 10.51 40 162155 2814 29787469
IgA nephropathy 13.49 10.51 21 162174 941 29789342
Complications of transplanted heart 13.48 10.51 11 162184 237 29790046
Pyomyositis 13.46 10.51 9 162186 141 29790142
Visual acuity reduced 13.39 10.51 138 162057 15708 29774575
Pemphigoid 13.38 10.51 78 162117 7450 29782833
Ejection fraction decreased 13.38 10.51 40 162155 15135 29775148
Anorectal varices 13.34 10.51 6 162189 40 29790243
Acute febrile neutrophilic dermatosis 13.34 10.51 23 162172 1123 29789160
Pulmonary cavitation 13.32 10.51 18 162177 708 29789575
Cerebral venous sinus thrombosis 13.32 10.51 12 162183 297 29789986
Alveolitis 13.29 10.51 29 162166 1688 29788595
Cataract subcapsular 13.28 10.51 11 162184 242 29790041
Aortic dissection 13.28 10.51 36 162159 2406 29787877
Histiocytosis 13.26 10.51 4 162191 6 29790277
Zika virus infection 13.26 10.51 4 162191 6 29790277
Purpura 13.26 10.51 96 162099 9871 29780412
Acute hepatitis B 13.24 10.51 8 162187 104 29790179
Helicobacter sepsis 13.18 10.51 5 162190 20 29790263
Pyuria 13.15 10.51 17 162178 640 29789643
Bowen's disease 13.14 10.51 9 162186 147 29790136
Body height below normal 13.10 10.51 11 162184 247 29790036
Drug reaction with eosinophilia and systemic symptoms 13.09 10.51 222 161973 28266 29762017
COVID-19 pneumonia 13.08 10.51 54 162141 4486 29785797
Papule 13.04 10.51 42 162153 3091 29787192
Phlebitis infective 13.04 10.51 9 162186 149 29790134
Respiratory tract infection fungal 13.03 10.51 17 162178 646 29789637
Mycobacterium marinum infection 13.02 10.51 11 162184 249 29790034
Enterocolitis 13.02 10.51 71 162124 6616 29783667
Obstructive airways disorder 13.01 10.51 18 162177 9041 29781242
Coronary artery aneurysm 12.99 10.51 7 162188 72 29790211
Eye abscess 12.98 10.51 9 162186 150 29790133
Citrobacter infection 12.93 10.51 15 162180 504 29789779
Hospice care 12.92 10.51 4 162191 4448 29785835
Cerebral cyst 12.92 10.51 10 162185 199 29790084
T-lymphocyte count decreased 12.92 10.51 10 162185 199 29790084
Myocardiac abscess 12.89 10.51 4 162191 7 29790276
Feeling hot 12.87 10.51 42 162153 15462 29774821
Peripheral T-cell lymphoma unspecified stage III 12.86 10.51 6 162189 44 29790239
Epstein-Barr viraemia 12.85 10.51 20 162175 896 29789387
Lumbar vertebral fracture 12.84 10.51 30 162165 1828 29788455
Osteomyelitis fungal 12.84 10.51 10 162185 201 29790082
Throat tightness 12.82 10.51 12 162183 7180 29783103
Hydronephrosis 12.82 10.51 88 162107 8895 29781388
Hypersensitivity pneumonitis 12.81 10.51 24 162171 1251 29789032
Limb injury 12.78 10.51 18 162177 8973 29781310
Glucose tolerance impaired 12.76 10.51 39 162156 2791 29787492
Influenza 12.76 10.51 162 162033 43236 29747047
Bronchial carcinoma 12.75 10.51 20 162175 902 29789381
Urinary tract obstruction 12.74 10.51 44 162151 3357 29786926
Calciphylaxis 12.73 10.51 22 162173 1076 29789207
Respiratory depression 12.72 10.51 27 162168 11476 29778807
Bone tuberculosis 12.70 10.51 12 162183 316 29789967
Folliculitis 12.70 10.51 46 162149 3594 29786689
Congenital thrombocytopenia 12.67 10.51 3 162192 0 29790283
Corneal epithelial microcysts 12.67 10.51 3 162192 0 29790283
Chronic graft versus host disease in eye 12.67 10.51 3 162192 0 29790283
Encephalitis post varicella 12.67 10.51 3 162192 0 29790283
Splint application 12.67 10.51 3 162192 0 29790283
Hyposplenism 12.67 10.51 3 162192 0 29790283
Blood testosterone decreased 12.67 10.51 4 162191 4392 29785891
Phagocytosis 12.67 10.51 3 162192 0 29790283
Nephritis bacterial 12.67 10.51 3 162192 0 29790283
Nodular vasculitis 12.67 10.51 3 162192 0 29790283
Leukoencephalopathy 12.65 10.51 49 162146 3953 29786330
Depressed level of consciousness 12.65 10.51 139 162056 38083 29752200
Post procedural bile leak 12.64 10.51 12 162183 318 29789965
Therapy non-responder 12.63 10.51 227 161968 29226 29761057
Antithrombin III decreased 12.63 10.51 13 162182 381 29789902
Pulmonary oedema 12.61 10.51 165 162030 43810 29746473
Chronic hepatitis 12.61 10.51 16 162179 591 29789692
Renal injury 12.58 10.51 28 162167 11701 29778582
Concomitant disease progression 12.57 10.51 36 162159 2484 29787799
Malabsorption 12.56 10.51 31 162164 1956 29788327
Sweat gland disorder 12.55 10.51 8 162187 115 29790168
Melanaemia 12.55 10.51 4 162191 8 29790275
Pelvic inflammatory disease 12.55 10.51 4 162191 8 29790275
Wound decomposition 12.53 10.51 6 162189 47 29790236
Hepatitis B core antibody positive 12.51 10.51 7 162188 78 29790205
Metastatic bronchial carcinoma 12.51 10.51 10 162185 209 29790074
Respiratory alkalosis 12.49 10.51 25 162170 1369 29788914
Cranial nerve paralysis 12.46 10.51 5 162190 24 29790259
Myelosuppression 12.46 10.51 75 162120 7247 29783036
Optic discs blurred 12.44 10.51 7 162188 79 29790204
Multiple sclerosis relapse 12.43 10.51 25 162170 10837 29779446
Neutropenic infection 12.42 10.51 21 162174 1009 29789274
Vasculitic rash 12.41 10.51 20 162175 923 29789360
Erysipelas 12.40 10.51 53 162142 4471 29785812
Ileus paralytic 12.40 10.51 62 162133 5586 29784697
Neurological symptom 12.40 10.51 44 162151 3403 29786880
Hip fracture 12.40 10.51 26 162169 11098 29779185
Eosinophil count increased 12.37 10.51 76 162119 7397 29782886
Mouth swelling 12.37 10.51 27 162168 1572 29788711
Aspergilloma 12.37 10.51 12 162183 327 29789956
Ventricular tachycardia 12.36 10.51 77 162118 23785 29766498
Sneezing 12.36 10.51 4 162191 4323 29785960
Precursor T-lymphoblastic lymphoma/leukaemia 12.36 10.51 7 162188 80 29790203
Myasthenia gravis 12.35 10.51 40 162155 2952 29787331
Oesophageal perforation 12.34 10.51 14 162181 459 29789824
Cavernous sinus thrombosis 12.32 10.51 8 162187 119 29790164
Autoimmune pancreatitis 12.32 10.51 11 162184 269 29790014
Complications of bone marrow transplant 12.31 10.51 10 162185 214 29790069
Tuberculosis gastrointestinal 12.31 10.51 10 162185 214 29790069
Pulmonary sepsis 12.30 10.51 31 162164 1982 29788301
Eosinophilic granulomatosis with polyangiitis 12.28 10.51 24 162171 1291 29788992
Fluid retention 12.27 10.51 82 162113 24916 29765367
Mood altered 12.25 10.51 16 162179 8234 29782049
Neutrophil percentage abnormal 12.23 10.51 4 162191 9 29790274
Lymphocyte percentage abnormal 12.23 10.51 4 162191 9 29790274
Emphysema 12.19 10.51 90 162105 9312 29780971
Pustule 12.16 10.51 9 162186 167 29790116
Dysarthria 12.14 10.51 106 162089 30384 29759899
Gastric ulcer haemorrhage 12.14 10.51 59 162136 5255 29785028
Typhoid fever 12.14 10.51 5 162190 26 29790257
Scleroderma 12.13 10.51 24 162171 1303 29788980
Megakaryocytes increased 12.11 10.51 6 162189 51 29790232
Microscopic polyangiitis 12.04 10.51 8 162187 124 29790159
Hepatitis B e antigen positive 12.01 10.51 6 162189 52 29790231
CSF glucose decreased 11.99 10.51 5 162190 27 29790256
Ecthyma 11.99 10.51 12 162183 340 29789943
Iris hypopigmentation 11.99 10.51 5 162190 27 29790256
Infected lymphocele 11.99 10.51 5 162190 27 29790256
Renal tubular atrophy 11.95 10.51 21 162174 1041 29789242
Angioimmunoblastic T-cell lymphoma stage IV 11.94 10.51 4 162191 10 29790273
Cardiac myxoma 11.94 10.51 4 162191 10 29790273
Gingival cancer 11.94 10.51 4 162191 10 29790273
Lemierre syndrome 11.94 10.51 4 162191 10 29790273
Lichen sclerosus 11.94 10.51 4 162191 10 29790273
Lupus pneumonitis 11.92 10.51 6 162189 53 29790230
Stent placement 11.86 10.51 5 162190 4591 29785692
Poor quality sleep 11.86 10.51 13 162182 7228 29783055
Gastrointestinal necrosis 11.84 10.51 42 162153 3247 29787036
Asymptomatic viral hepatitis 11.84 10.51 5 162190 28 29790255
Myocardial calcification 11.84 10.51 5 162190 28 29790255
Diverticular perforation 11.81 10.51 41 162154 3136 29787147
Drug eruption 11.80 10.51 146 162049 17380 29772903
Drug therapeutic incompatibility 11.77 10.51 8 162187 129 29790154
Encapsulating peritoneal sclerosis 11.77 10.51 16 162179 633 29789650
Cutaneous leishmaniasis 11.77 10.51 8 162187 129 29790154
Haemorrhage 11.76 10.51 177 162018 45902 29744381
Libido decreased 11.74 10.51 5 162190 4561 29785722
Acute lymphocytic leukaemia 11.73 10.51 40 162155 3032 29787251
Paratracheal lymphadenopathy 11.72 10.51 7 162188 89 29790194
Cytomegalovirus gastrointestinal infection 11.71 10.51 8 162187 130 29790153
Mononeuropathy multiplex 11.71 10.51 8 162187 130 29790153
Mucosal haemorrhage 11.71 10.51 25 162170 1433 29788850
Retinal disorder 11.71 10.51 20 162175 969 29789314
Congenital hepatobiliary anomaly 11.69 10.51 5 162190 29 29790254
Oesophageal tuberculosis 11.67 10.51 4 162191 11 29790272
Acid fast bacilli infection 11.65 10.51 7 162188 90 29790193
Fungal abscess central nervous system 11.64 10.51 6 162189 56 29790227
VIth nerve paralysis 11.63 10.51 17 162178 720 29789563
Gene mutation 11.62 10.51 18 162177 803 29789480
Ankylosing spondylitis 11.60 10.51 5 162190 4529 29785754
Pharyngitis 11.59 10.51 70 162125 6772 29783511
Blood pressure diastolic decreased 11.58 10.51 10 162185 6221 29784062
Sinus disorder 11.56 10.51 10 162185 6215 29784068
Intestinal villi atrophy 11.56 10.51 8 162187 133 29790150
Pulmonary artery thrombosis 11.56 10.51 16 162179 644 29789639
Granulocytopenia neonatal 11.55 10.51 5 162190 30 29790253
Viral uveitis 11.55 10.51 5 162190 30 29790253
Nodule 11.55 10.51 54 162141 4734 29785549
Eye infection staphylococcal 11.54 10.51 6 162189 57 29790226
Necrotising fasciitis 11.54 10.51 43 162152 3406 29786877
Immunodeficiency 11.54 10.51 50 162145 4244 29786039
Encephalopathy 11.52 10.51 115 162080 32090 29758193
Prostate cancer 11.49 10.51 188 162007 23769 29766514
Nocturia 11.46 10.51 17 162178 8295 29781988
Graft versus host disease in lung 11.44 10.51 14 162181 498 29789785
Paternal exposure timing unspecified 11.42 10.51 5 162190 31 29790252
Type 3 diabetes mellitus 11.42 10.51 5 162190 31 29790252
Peripheral T-cell lymphoma unspecified refractory 11.42 10.51 4 162191 12 29790271
CD4/CD8 ratio decreased 11.42 10.51 4 162191 12 29790271
Angioedema 11.40 10.51 125 162070 34259 29756024
Xanthelasma 11.39 10.51 7 162188 94 29790189
Psychotic disorder 11.37 10.51 69 162126 21446 29768837
Pancreatic duct stenosis 11.34 10.51 9 162186 186 29790097
Prostatic specific antigen increased 11.34 10.51 107 162088 11897 29778386
Prescribed overdose 11.33 10.51 18 162177 8543 29781740
Disorientation 11.32 10.51 112 162083 31306 29758977
Obesity 11.31 10.51 18 162177 8537 29781746
Respiratory tract congestion 11.29 10.51 8 162187 5498 29784785
Brucellosis 11.29 10.51 5 162190 32 29790251
Hypocomplementaemia 11.29 10.51 5 162190 32 29790251
Proctocolectomy 11.28 10.51 6 162189 60 29790223
Duodenal perforation 11.28 10.51 22 162173 1182 29789101
Myeloproliferative neoplasm 11.27 10.51 13 162182 434 29789849
Reticulocytosis 11.27 10.51 11 162184 302 29789981
Neutropenic colitis 11.26 10.51 32 162163 2198 29788085
Ear infection 11.26 10.51 14 162181 7360 29782923
Chest expansion decreased 11.26 10.51 8 162187 139 29790144
Nightmare 11.26 10.51 31 162164 12045 29778238
Renal salt-wasting syndrome 11.26 10.51 8 162187 139 29790144
Immune thrombocytopenia 11.21 10.51 75 162120 7516 29782767
Bone marrow necrosis 11.21 10.51 8 162187 140 29790143
Decreased appetite 11.20 10.51 681 161514 149229 29641054
Infected neoplasm 11.20 10.51 6 162189 61 29790222
Mantle cell lymphoma stage IV 11.20 10.51 6 162189 61 29790222
Blood lactate dehydrogenase 11.18 10.51 4 162191 13 29790270
Haemophilus bacteraemia 11.18 10.51 4 162191 13 29790270
Pulse absent 11.16 10.51 8 162187 5465 29784818
JC virus CSF test positive 11.14 10.51 7 162188 98 29790185
Hypoproteinaemia 11.13 10.51 28 162167 1788 29788495
Gout 11.11 10.51 52 162143 17263 29773020
Eye pain 11.09 10.51 105 162090 11684 29778599
Subcapsular renal haematoma 11.09 10.51 12 162183 373 29789910
Endocarditis enterococcal 11.08 10.51 7 162188 99 29790184
Prescribed underdose 11.06 10.51 76 162119 7683 29782600
Bone infarction 11.05 10.51 10 162185 249 29790034
Escherichia urinary tract infection 11.04 10.51 38 162157 2894 29787389
Renal infarct 11.03 10.51 21 162174 1108 29789175
Tooth erosion 11.02 10.51 7 162188 100 29790183
Seasonal allergy 11.00 10.51 6 162189 4747 29785536
Stenotrophomonas infection 10.98 10.51 26 162169 1598 29788685
Acanthamoeba keratitis 10.96 10.51 7 162188 101 29790182
Endotoxic shock 10.96 10.51 4 162191 14 29790269
Neisseria infection 10.96 10.51 4 162191 14 29790269
Rotator cuff syndrome 10.93 10.51 8 162187 5405 29784878
Gastrointestinal candidiasis 10.92 10.51 8 162187 146 29790137
Pachymeningitis 10.90 10.51 7 162188 102 29790181
Shock haemorrhagic 10.90 10.51 91 162104 9774 29780509
Blood cholesterol increased 10.87 10.51 51 162144 16919 29773364
Thyroid gland abscess 10.87 10.51 6 162189 65 29790218
Hyperplasia 10.83 10.51 14 162181 527 29789756
Wound infection pseudomonas 10.82 10.51 10 162185 256 29790027
Pancreatitis 10.80 10.51 136 162059 36354 29753929
Diffuse alveolar damage 10.80 10.51 29 162166 1927 29788356
Renal and pancreas transplant rejection 10.79 10.51 5 162190 36 29790247
Cancer fatigue 10.79 10.51 5 162190 36 29790247
Genotoxicity 10.79 10.51 5 162190 36 29790247
Infected skin ulcer 10.78 10.51 24 162171 1416 29788867
Rectal cancer 10.77 10.51 31 162164 2145 29788138
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.76 10.51 15 162180 608 29789675
Thyroid stimulating hormone deficiency 10.75 10.51 4 162191 15 29790268
Lung lobectomy 10.75 10.51 4 162191 15 29790268
Lung adenocarcinoma stage III 10.75 10.51 4 162191 15 29790268
Adrenal atrophy 10.75 10.51 4 162191 15 29790268
Bone abscess 10.74 10.51 8 162187 150 29790133
Central nervous system vasculitis 10.74 10.51 12 162183 387 29789896
Mucosal ulceration 10.72 10.51 18 162177 860 29789423
Evans syndrome 10.69 10.51 10 162185 260 29790023
Small intestinal haemorrhage 10.69 10.51 30 162165 2046 29788237
Dyspnoea 10.69 10.51 1613 160582 331682 29458601
Cytopenia 10.69 10.51 79 162116 8177 29782106
Infusion site discolouration 10.67 10.51 7 162188 106 29790177
HIV associated nephropathy 10.66 10.51 10 162185 261 29790022
Acute graft versus host disease in liver 10.65 10.51 22 162173 1232 29789051
Aortitis 10.65 10.51 8 162187 152 29790131
Wound dehiscence 10.64 10.51 41 162154 3300 29786983
Renal tubular injury 10.63 10.51 15 162180 615 29789668
Renal artery occlusion 10.62 10.51 7 162188 107 29790176
Pearly penile papules 10.61 10.51 3 162192 3 29790280
Lymphocyte transformation test positive 10.61 10.51 3 162192 3 29790280
Ocular vasculitis 10.61 10.51 3 162192 3 29790280
Still's disease 10.61 10.51 3 162192 3 29790280
Tracheal ulcer 10.61 10.51 3 162192 3 29790280
Chlamydia test positive 10.61 10.51 3 162192 3 29790280
Aortic injury 10.61 10.51 3 162192 3 29790280
Precursor T-lymphoblastic lymphoma/leukaemia stage I 10.61 10.51 3 162192 3 29790280
Human papilloma virus test positive 10.61 10.51 3 162192 3 29790280
Gastric pneumatosis 10.61 10.51 3 162192 3 29790280
Monocyte count abnormal 10.57 10.51 5 162190 38 29790245
Hypomagnesaemia 10.56 10.51 50 162145 16548 29773735
Purulence 10.56 10.51 19 162176 960 29789323
Silicosis 10.55 10.51 4 162191 16 29790267
Mitochondrial myopathy acquired 10.55 10.51 4 162191 16 29790267
Rectal lesion 10.55 10.51 4 162191 16 29790267
Prostatomegaly 10.52 10.51 6 162189 4630 29785653
Pneumonia adenoviral 10.52 10.51 8 162187 155 29790128

Pharmacologic Action:

SourceCodeDescription
ATC A07EA01 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC C05AA04 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AA03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, weak (group I)
ATC D07XA02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, weak, other combinations
ATC H02AB06 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD02 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BA04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CB02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA03 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S03BA02 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC A01AC54 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC D07BA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, weak, combinations with antiseptics
ATC D07CA03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, weak, combinations with antibiotics
ATC R01AD52 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BB02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids and mydriatics in combination
ATC S01CA02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S02CA01 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03CA02 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC V03AB05 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:37962 adrenergic neuron agents
CHEBI has role CHEBI:49103 drug metabolites
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Keratitis indication 5888003 DOID:4677
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Extrinsic allergic alveolitis indication 37471005 DOID:841
Allergic bronchopulmonary aspergillosis indication 37981002 DOID:13166
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Fibrosis of lung indication 51615001 DOID:3770
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Ulcerative colitis indication 64766004 DOID:8577
Löffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Polymyalgia rheumatica indication 65323003 DOID:853
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Stevens-Johnson syndrome indication 73442001 DOID:0050426
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Sympathetic uveitis indication 75315001 DOID:12029
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Sjögren's syndrome indication 83901003 DOID:12894
Bursitis indication 84017003 DOID:2965
Dacryocystitis indication 85777005 DOID:9938
Autoimmune disease indication 85828009
Corneal abrasion indication 85848002
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Bacterial conjunctivitis indication 128350005 DOID:9700
Uveitis indication 128473001 DOID:13141
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Ocular rosacea indication 200933006
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Meibomianitis indication 309779001
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Eosinophilic asthma indication 367542003 DOID:9498
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Giant cell arteritis indication 414341000 DOID:13375
Pneumocystosis jiroveci pneumonia indication 415125002 DOID:11339
Synovitis indication 416209007 DOID:2703
Allergic conjunctivitis indication 473460002 DOID:11204
Post traumatic osteoarthritis indication 699262001
Superficial Ocular Infection indication
Severe Ocular Inflammation indication
Synovitis due to Osteoarthritis indication
Transfusion Reaction Urticaria indication
Erythroblastic Anemia indication
Progressive Diffuse Large B-Cell Lymphoma indication
Diagnostic Test for Cushing's Syndrome indication
Systemic Dermatomyositis indication
Post-Op Ocular Inflammation indication
Otitis externa off-label use 3135009
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Pulmonary edema off-label use 19242006 DOID:11396
Shock off-label use 27942005
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Anaphylaxis off-label use 39579001
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Myasthenia gravis off-label use 91637004 DOID:437
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Bell's palsy off-label use 193093009 DOID:12506
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Allergic otitis externa off-label use 405821001
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Otitis Externa Eczema off-label use
Obstructive Bronchiolitis off-label use
Neuroendocrine Prostate Carcinoma off-label use
Metastatic Prostate Carcinoma off-label use
Otitis Externa Seborrhea off-label use
Prevention of Cytarabine-Induced Keratoconjunctivitis off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Prevention of Post-Extubation Laryngeal Edema off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Herpes simplex keratitis contraindication 9389005
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Skin striae contraindication 201066002
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Injury of eye region contraindication 282752000
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Osteopenia contraindication 312894000
Vaccinia keratitis contraindication 397552005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Traumatic rupture of tendon contraindication 415749005
Porphyria contraindication 418470004
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.18 acidic
pKa2 12.91 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 7.80 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Mineralocorticoid receptor Nuclear hormone receptor Ki 9.54 CHEMBL
Androgen receptor Nuclear hormone receptor Ki 5.60 CHEMBL
Glutamine synthetase Enzyme EC50 7.49 CHEMBL
Corticosteroid-binding globulin Secreted Ki 7.51 CHEMBL
Interleukin-6 Cytokine IC50 8.38 CHEMBL
Disintegrin and metalloproteinase domain-containing protein 17 Unclassified IC50 7.83 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 5.58 CHEMBL
Glucocorticoid receptor Transcription factor EC50 8.47 CHEMBL

External reference:

IDSource
4017988 VUID
N0000146334 NUI
D00472 KEGG_DRUG
4017988 VANDF
C0032950 UMLSCUI
CHEBI:8378 CHEBI
TUA PDB_CHEM_ID
CHEMBL131 ChEMBL_ID
DB00860 DRUGBANK_ID
D011239 MESH_DESCRIPTOR_UI
5755 PUBCHEM_CID
2866 IUPHAR_LIGAND_ID
535 INN_ID
9PHQ9Y1OLM UNII
8638 RXNORM
5347 MMSL
59710 MMSL
d00084 MMSL
002155 NDDF
116601002 SNOMEDCT_US
52388000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PrednisoLONE HUMAN PRESCRIPTION DRUG LABEL 1 0527-5406 SYRUP 15 mg ORAL ANDA 14 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 12634-686 SOLUTION 15 mg ORAL ANDA 11 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 16590-291 SOLUTION 15 mg ORAL ANDA 11 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 21695-365 SOLUTION 15 mg ORAL ANDA 12 sections
MILLIPRED HUMAN PRESCRIPTION DRUG LABEL 1 23594-505 TABLET 5 mg ORAL ANDA 13 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 33261-475 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-0655 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-0655 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50383-042 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 53217-193 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 54868-4748 SYRUP 5 mg ORAL ANDA 10 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 54868-4749 SYRUP 15 mg ORAL ANDA 10 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 58177-910 SYRUP 15 mg ORAL ANDA 10 sections
PREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 61919-291 SOLUTION 15 mg ORAL ANDA 10 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 63187-466 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 63629-1862 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 66116-603 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 67296-1656 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 68258-8987 SOLUTION 15 mg ORAL ANDA 12 sections
Prednisolone HUMAN PRESCRIPTION DRUG LABEL 1 68788-9096 SOLUTION 15 mg ORAL ANDA 12 sections
CAMBISON HUMAN OTC DRUG LABEL 2 72689-0016 OINTMENT 4 mg TOPICAL unapproved drug other 7 sections