Stem definition | Drug id | CAS RN |
---|---|---|
steroids for topical use, acetal derivatives | 419 | 51333-22-3 |
Dose | Unit | Route |
---|---|---|
9 | mg | O |
2 | mg | SL |
0.20 | mg | N |
0.80 | mg | Inhal.aerosol |
0.80 | mg | Inhal.powder |
1.50 | mg | Inhal.solution |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.02 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.04 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 37 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3.90 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.13 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 14, 1994 | FDA | ||
June 18, 2019 | PMDA | AstraZeneca K.K. | |
Aug. 1, 2018 | EMA | Dr. Falk Pharma GmbH |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 1811.75 | 9.92 | 1345 | 80314 | 87992 | 50435473 |
Wheezing | 692.39 | 9.92 | 663 | 80996 | 61384 | 50462081 |
Dyspnoea | 557.87 | 9.92 | 2039 | 79620 | 545569 | 49977896 |
Obstructive airways disorder | 533.65 | 9.92 | 326 | 81333 | 15326 | 50508139 |
Cough | 315.24 | 9.92 | 979 | 80680 | 240285 | 50283180 |
Chest discomfort | 269.54 | 9.92 | 513 | 81146 | 92209 | 50431256 |
Sleep disorder due to a general medical condition | 227.10 | 9.92 | 144 | 81515 | 7227 | 50516238 |
Full blood count abnormal | 202.26 | 9.92 | 218 | 81441 | 23170 | 50500295 |
Macular degeneration | 195.80 | 9.92 | 172 | 81487 | 14216 | 50509249 |
Eosinophil count increased | 189.69 | 9.92 | 138 | 81521 | 8692 | 50514773 |
Eosinophilic bronchitis | 184.18 | 9.92 | 56 | 81603 | 427 | 50523038 |
Contraindicated product administered | 173.45 | 9.92 | 19 | 81640 | 148939 | 50374526 |
Systemic lupus erythematosus | 171.44 | 9.92 | 15 | 81644 | 140607 | 50382858 |
Chronic obstructive pulmonary disease | 154.35 | 9.92 | 295 | 81364 | 53140 | 50470325 |
Completed suicide | 143.41 | 9.92 | 21 | 81638 | 131868 | 50391597 |
Hand deformity | 143.04 | 9.92 | 4 | 81655 | 100195 | 50423270 |
Chronic sinusitis | 136.47 | 9.92 | 98 | 81561 | 6047 | 50517418 |
Toxicity to various agents | 134.25 | 9.92 | 89 | 81570 | 212410 | 50311055 |
Colitis ulcerative | 133.42 | 9.92 | 150 | 81509 | 16704 | 50506761 |
Pneumonia | 133.19 | 9.92 | 1054 | 80605 | 377347 | 50146118 |
Nasal polyps | 132.41 | 9.92 | 70 | 81589 | 2484 | 50520981 |
Respiratory symptom | 130.38 | 9.92 | 68 | 81591 | 2346 | 50521119 |
Alopecia | 123.49 | 9.92 | 128 | 81531 | 244919 | 50278546 |
Arthropathy | 120.42 | 9.92 | 52 | 81607 | 157854 | 50365611 |
Productive cough | 120.33 | 9.92 | 264 | 81395 | 52430 | 50471035 |
Synovitis | 115.07 | 9.92 | 29 | 81630 | 123836 | 50399629 |
Gastrooesophageal reflux disease | 112.53 | 9.92 | 324 | 81335 | 76104 | 50447361 |
Asthmatic crisis | 111.89 | 9.92 | 54 | 81605 | 1574 | 50521891 |
Blood test abnormal | 109.43 | 9.92 | 112 | 81547 | 11207 | 50512258 |
Glossodynia | 109.42 | 9.92 | 26 | 81633 | 115543 | 50407922 |
Treatment failure | 105.45 | 9.92 | 45 | 81614 | 137592 | 50385873 |
Sputum discoloured | 103.95 | 9.92 | 118 | 81541 | 13277 | 50510188 |
Forced expiratory volume decreased | 99.70 | 9.92 | 71 | 81588 | 4323 | 50519142 |
Upper-airway cough syndrome | 98.30 | 9.92 | 93 | 81566 | 8457 | 50515008 |
Polyp | 97.50 | 9.92 | 77 | 81582 | 5485 | 50517980 |
Pericarditis | 96.95 | 9.92 | 8 | 81651 | 78681 | 50444784 |
Rheumatoid arthritis | 92.00 | 9.92 | 115 | 81544 | 202435 | 50321030 |
Swelling | 90.24 | 9.92 | 115 | 81544 | 200757 | 50322708 |
Labile blood pressure | 87.48 | 9.92 | 46 | 81613 | 1614 | 50521851 |
Pain | 86.92 | 9.92 | 563 | 81096 | 578340 | 49945125 |
Polycystic ovaries | 85.29 | 9.92 | 52 | 81607 | 2432 | 50521033 |
Bronchospasm | 84.69 | 9.92 | 112 | 81547 | 14742 | 50508723 |
Middle insomnia | 83.18 | 9.92 | 91 | 81568 | 9830 | 50513635 |
Febrile neutropenia | 83.07 | 9.92 | 27 | 81632 | 97640 | 50425825 |
Neutrophilia | 79.35 | 9.92 | 57 | 81602 | 3518 | 50519947 |
Joint swelling | 78.28 | 9.92 | 175 | 81484 | 245111 | 50278354 |
Blood immunoglobulin E increased | 77.47 | 9.92 | 48 | 81611 | 2311 | 50521154 |
Bronchial secretion retention | 77.11 | 9.92 | 41 | 81618 | 1472 | 50521993 |
Abdominal discomfort | 76.62 | 9.92 | 162 | 81497 | 231479 | 50291986 |
Sleep apnoea syndrome | 71.64 | 9.92 | 134 | 81525 | 23734 | 50499731 |
Heart rate increased | 71.39 | 9.92 | 280 | 81379 | 76970 | 50446495 |
Rhinitis allergic | 70.98 | 9.92 | 72 | 81587 | 7128 | 50516337 |
Eosinophilic granulomatosis with polyangiitis | 69.89 | 9.92 | 42 | 81617 | 1913 | 50521552 |
Growth failure | 67.93 | 9.92 | 24 | 81635 | 306 | 50523159 |
Reversible airways obstruction | 67.59 | 9.92 | 33 | 81626 | 987 | 50522478 |
Anaphylactic reaction | 66.29 | 9.92 | 215 | 81444 | 53840 | 50469625 |
Wound | 65.81 | 9.92 | 45 | 81614 | 105749 | 50417716 |
Hepatic enzyme increased | 65.53 | 9.92 | 75 | 81584 | 137305 | 50386160 |
Sinusitis fungal | 65.46 | 9.92 | 35 | 81624 | 1271 | 50522194 |
Drug intolerance | 63.03 | 9.92 | 165 | 81494 | 218939 | 50304526 |
White blood cell count decreased | 62.14 | 9.92 | 58 | 81601 | 116664 | 50406801 |
Sensitisation | 61.83 | 9.92 | 36 | 81623 | 1546 | 50521919 |
Vital capacity decreased | 60.58 | 9.92 | 30 | 81629 | 926 | 50522539 |
Loss of personal independence in daily activities | 60.01 | 9.92 | 248 | 81411 | 69802 | 50453663 |
Drug abuse | 59.59 | 9.92 | 12 | 81647 | 59834 | 50463631 |
Dyspnoea exertional | 59.44 | 9.92 | 200 | 81459 | 51033 | 50472432 |
Hyper IgE syndrome | 58.01 | 9.92 | 23 | 81636 | 411 | 50523054 |
Upper respiratory fungal infection | 57.59 | 9.92 | 18 | 81641 | 152 | 50523313 |
Dysphonia | 57.32 | 9.92 | 165 | 81494 | 38727 | 50484738 |
Impaired healing | 56.39 | 9.92 | 21 | 81638 | 69765 | 50453700 |
Sputum increased | 56.32 | 9.92 | 36 | 81623 | 1831 | 50521634 |
Bronchiectasis | 56.27 | 9.92 | 76 | 81583 | 10207 | 50513258 |
Respiratory tract infection | 54.30 | 9.92 | 143 | 81516 | 31874 | 50491591 |
Intentional overdose | 53.63 | 9.92 | 17 | 81642 | 62487 | 50460978 |
Frequent bowel movements | 53.30 | 9.92 | 87 | 81572 | 13831 | 50509634 |
Embolism venous | 53.18 | 9.92 | 39 | 81620 | 2486 | 50520979 |
Salpingo-oophorectomy unilateral | 53.12 | 9.92 | 23 | 81636 | 518 | 50522947 |
Nasal congestion | 52.77 | 9.92 | 192 | 81467 | 50928 | 50472537 |
Neutropenia | 51.85 | 9.92 | 100 | 81559 | 147865 | 50375600 |
Rheumatoid factor positive | 51.77 | 9.92 | 9 | 81650 | 49850 | 50473615 |
Thrombocytopenia | 50.44 | 9.92 | 80 | 81579 | 127593 | 50395872 |
Lung diffusion test abnormal | 49.43 | 9.92 | 16 | 81643 | 153 | 50523312 |
Circumstance or information capable of leading to medication error | 49.26 | 9.92 | 41 | 81618 | 3147 | 50520318 |
Peak expiratory flow rate decreased | 48.11 | 9.92 | 22 | 81637 | 566 | 50522899 |
Emphysema | 47.93 | 9.92 | 66 | 81593 | 9027 | 50514438 |
Ventricular failure | 47.44 | 9.92 | 19 | 81640 | 349 | 50523116 |
Sputum culture positive | 47.02 | 9.92 | 29 | 81630 | 1385 | 50522080 |
Platelet count decreased | 46.94 | 9.92 | 56 | 81603 | 100670 | 50422795 |
Hypothyroidism | 46.68 | 9.92 | 141 | 81518 | 33984 | 50489481 |
Stomatitis | 46.53 | 9.92 | 57 | 81602 | 101287 | 50422178 |
Eosinophilia | 45.47 | 9.92 | 96 | 81563 | 18556 | 50504909 |
Butterfly rash | 45.35 | 9.92 | 27 | 81632 | 1209 | 50522256 |
Death | 44.89 | 9.92 | 324 | 81335 | 325055 | 50198410 |
Peripheral swelling | 44.60 | 9.92 | 176 | 81483 | 205760 | 50317705 |
Hepatic ischaemia | 44.42 | 9.92 | 21 | 81638 | 584 | 50522881 |
Therapeutic product effect decreased | 44.22 | 9.92 | 96 | 81563 | 135954 | 50387511 |
Ejection fraction | 43.47 | 9.92 | 26 | 81633 | 1174 | 50522291 |
Bronchitis | 43.16 | 9.92 | 302 | 81357 | 103857 | 50419608 |
Therapeutic product effect incomplete | 43.14 | 9.92 | 274 | 81385 | 91241 | 50432224 |
Malignant neoplasm progression | 42.33 | 9.92 | 29 | 81630 | 68095 | 50455370 |
Intestinal stenosis | 42.04 | 9.92 | 34 | 81625 | 2506 | 50520959 |
Aspergillus infection | 41.32 | 9.92 | 53 | 81606 | 6768 | 50516697 |
Pancytopenia | 41.01 | 9.92 | 45 | 81614 | 83985 | 50439480 |
Female genital tract fistula | 40.48 | 9.92 | 39 | 81620 | 3627 | 50519838 |
Graft versus host disease in gastrointestinal tract | 39.35 | 9.92 | 34 | 81625 | 2747 | 50520718 |
Infective pulmonary exacerbation of cystic fibrosis | 38.12 | 9.92 | 55 | 81604 | 7854 | 50515611 |
Systemic mycosis | 37.75 | 9.92 | 23 | 81636 | 1074 | 50522391 |
Throat irritation | 37.71 | 9.92 | 121 | 81538 | 30118 | 50493347 |
Sinusitis | 37.24 | 9.92 | 430 | 81229 | 170128 | 50353337 |
Sinus disorder | 37.14 | 9.92 | 88 | 81571 | 18370 | 50505095 |
Restrictive pulmonary disease | 36.97 | 9.92 | 25 | 81634 | 1399 | 50522066 |
Hepatorenal syndrome | 36.88 | 9.92 | 27 | 81632 | 1716 | 50521749 |
Infusion related reaction | 36.64 | 9.92 | 145 | 81514 | 169412 | 50354053 |
Bacterial infection | 36.49 | 9.92 | 81 | 81578 | 16200 | 50507265 |
Breath sounds abnormal | 35.83 | 9.92 | 53 | 81606 | 7739 | 50515726 |
Bulimia nervosa | 35.75 | 9.92 | 16 | 81643 | 391 | 50523074 |
Intentional device misuse | 35.66 | 9.92 | 19 | 81640 | 685 | 50522780 |
Discomfort | 35.61 | 9.92 | 76 | 81583 | 108304 | 50415161 |
Acute kidney injury | 35.48 | 9.92 | 219 | 81440 | 227839 | 50295626 |
Blister | 35.19 | 9.92 | 52 | 81607 | 85366 | 50438099 |
Hip arthroplasty | 35.08 | 9.92 | 4 | 81655 | 30425 | 50493040 |
Anosmia | 34.60 | 9.92 | 37 | 81622 | 3894 | 50519571 |
Abdominal pain | 34.50 | 9.92 | 554 | 81105 | 235674 | 50287791 |
Respiratory tract inflammation | 34.38 | 9.92 | 17 | 81642 | 523 | 50522942 |
Vocal cord dysfunction | 34.19 | 9.92 | 15 | 81644 | 349 | 50523116 |
Venous pressure jugular increased | 34.11 | 9.92 | 17 | 81642 | 532 | 50522933 |
Ileal stenosis | 33.89 | 9.92 | 24 | 81635 | 1448 | 50522017 |
Blood pressure increased | 33.84 | 9.92 | 346 | 81313 | 132786 | 50390679 |
Pulmonary function test decreased | 33.61 | 9.92 | 34 | 81625 | 3354 | 50520111 |
Therapeutic reaction time decreased | 33.36 | 9.92 | 23 | 81636 | 1329 | 50522136 |
Muscle relaxant therapy | 33.21 | 9.92 | 12 | 81647 | 164 | 50523301 |
Fall | 32.78 | 9.92 | 364 | 81295 | 334568 | 50188897 |
Herpes simplex oesophagitis | 32.77 | 9.92 | 11 | 81648 | 119 | 50523346 |
Oropharyngeal pain | 32.47 | 9.92 | 226 | 81433 | 77575 | 50445890 |
Eczema | 32.18 | 9.92 | 95 | 81564 | 22607 | 50500858 |
Adrenal suppression | 31.86 | 9.92 | 19 | 81640 | 853 | 50522612 |
Oropharyngeal discomfort | 31.67 | 9.92 | 35 | 81624 | 3823 | 50519642 |
Cystic fibrosis | 30.74 | 9.92 | 30 | 81629 | 2834 | 50520631 |
Rash | 30.36 | 9.92 | 510 | 81149 | 436961 | 50086504 |
Rhonchi | 30.22 | 9.92 | 27 | 81632 | 2280 | 50521185 |
Upper respiratory tract infection | 29.63 | 9.92 | 195 | 81464 | 65703 | 50457762 |
Frustration tolerance decreased | 29.63 | 9.92 | 41 | 81618 | 5633 | 50517832 |
Total lung capacity decreased | 29.61 | 9.92 | 21 | 81638 | 1270 | 50522195 |
Bronchopulmonary aspergillosis allergic | 28.77 | 9.92 | 20 | 81639 | 1171 | 50522294 |
Gastrointestinal wall thickening | 28.20 | 9.92 | 19 | 81640 | 1057 | 50522408 |
Hiatus hernia | 28.17 | 9.92 | 79 | 81580 | 18265 | 50505200 |
Intestinal obstruction | 27.99 | 9.92 | 100 | 81559 | 26283 | 50497182 |
Weight decreased | 27.98 | 9.92 | 507 | 81152 | 220738 | 50302727 |
Blood cholesterol increased | 27.57 | 9.92 | 29 | 81630 | 55186 | 50468279 |
Off label use | 27.35 | 9.92 | 978 | 80681 | 473448 | 50050017 |
Drug specific antibody | 27.22 | 9.92 | 23 | 81636 | 1802 | 50521663 |
Decreased appetite | 27.21 | 9.92 | 201 | 81458 | 200722 | 50322743 |
Bronchomalacia | 27.03 | 9.92 | 11 | 81648 | 211 | 50523254 |
Neutrophil count decreased | 26.76 | 9.92 | 21 | 81638 | 46005 | 50477460 |
Hypotension | 26.69 | 9.92 | 247 | 81412 | 235222 | 50288243 |
Rhinorrhoea | 26.53 | 9.92 | 158 | 81501 | 51425 | 50472040 |
Respiratory distress | 26.14 | 9.92 | 108 | 81551 | 30381 | 50493084 |
Cushingoid | 26.07 | 9.92 | 42 | 81617 | 6603 | 50516862 |
Laryngeal stenosis | 25.62 | 9.92 | 16 | 81643 | 781 | 50522684 |
Infective exacerbation of chronic obstructive airways disease | 25.36 | 9.92 | 18 | 81641 | 1090 | 50522375 |
Dust allergy | 25.22 | 9.92 | 14 | 81645 | 548 | 50522917 |
Eosinophilic oesophagitis | 25.15 | 9.92 | 11 | 81648 | 254 | 50523211 |
Bronchial obstruction | 25.10 | 9.92 | 19 | 81640 | 1271 | 50522194 |
Coma | 25.05 | 9.92 | 33 | 81626 | 56846 | 50466619 |
Status asthmaticus | 24.97 | 9.92 | 16 | 81643 | 817 | 50522648 |
Superinfection | 24.85 | 9.92 | 23 | 81636 | 2033 | 50521432 |
Multiple allergies | 24.75 | 9.92 | 47 | 81612 | 8416 | 50515049 |
Disease progression | 24.72 | 9.92 | 76 | 81583 | 95790 | 50427675 |
Palpitations | 24.66 | 9.92 | 247 | 81412 | 94259 | 50429206 |
Bone marrow failure | 24.63 | 9.92 | 7 | 81652 | 27617 | 50495848 |
Sleep disorder due to general medical condition, insomnia type | 24.51 | 9.92 | 10 | 81649 | 31437 | 50492028 |
Multiple sclerosis relapse | 24.48 | 9.92 | 20 | 81639 | 42944 | 50480521 |
Device expulsion | 24.44 | 9.92 | 8 | 81651 | 28814 | 50494651 |
Obstruction | 24.34 | 9.92 | 23 | 81636 | 2088 | 50521377 |
Diastolic dysfunction | 24.29 | 9.92 | 36 | 81623 | 5266 | 50518199 |
Psoriatic arthropathy | 24.28 | 9.92 | 24 | 81635 | 47008 | 50476457 |
Graft versus host disease in skin | 24.18 | 9.92 | 25 | 81634 | 2531 | 50520934 |
Ascites | 24.01 | 9.92 | 14 | 81645 | 35847 | 50487618 |
Intestinal resection | 23.93 | 9.92 | 24 | 81635 | 2343 | 50521122 |
Respiration abnormal | 23.89 | 9.92 | 35 | 81624 | 5067 | 50518398 |
Mobility decreased | 23.88 | 9.92 | 59 | 81600 | 79889 | 50443576 |
Pseudomonas infection | 23.53 | 9.92 | 49 | 81610 | 9381 | 50514084 |
Aphonia | 23.47 | 9.92 | 46 | 81613 | 8432 | 50515033 |
Respiratory disorder | 23.31 | 9.92 | 106 | 81553 | 31081 | 50492384 |
Arthritis enteropathic | 23.27 | 9.92 | 10 | 81649 | 221 | 50523244 |
Infusion site extravasation | 23.26 | 9.92 | 41 | 81618 | 6935 | 50516530 |
Somnolence | 22.97 | 9.92 | 151 | 81508 | 154834 | 50368631 |
Pouchitis | 22.93 | 9.92 | 12 | 81647 | 417 | 50523048 |
Periorbital oedema | 22.92 | 9.92 | 34 | 81625 | 4978 | 50518487 |
Lung disorder | 22.90 | 9.92 | 137 | 81522 | 44662 | 50478803 |
Drug hypersensitivity | 22.89 | 9.92 | 277 | 81382 | 250733 | 50272732 |
Sputum purulent | 22.86 | 9.92 | 16 | 81643 | 947 | 50522518 |
Confusional state | 22.84 | 9.92 | 191 | 81468 | 185737 | 50337728 |
Obstructive pancreatitis | 22.82 | 9.92 | 10 | 81649 | 232 | 50523233 |
Irritable bowel syndrome | 22.49 | 9.92 | 30 | 81629 | 51411 | 50472054 |
Pharyngeal hypoaesthesia | 22.43 | 9.92 | 10 | 81649 | 242 | 50523223 |
Intentional self-injury | 22.25 | 9.92 | 5 | 81654 | 23107 | 50500358 |
Haemoptysis | 22.25 | 9.92 | 91 | 81568 | 25482 | 50497983 |
Nausea | 21.85 | 9.92 | 924 | 80735 | 704474 | 49818991 |
Overdose | 21.71 | 9.92 | 85 | 81574 | 99642 | 50423823 |
Increased upper airway secretion | 21.56 | 9.92 | 26 | 81633 | 3118 | 50520347 |
Adrenal insufficiency | 21.54 | 9.92 | 61 | 81598 | 14182 | 50509283 |
Candida infection | 21.50 | 9.92 | 85 | 81574 | 23438 | 50500027 |
Crohn's disease | 21.49 | 9.92 | 32 | 81627 | 4701 | 50518764 |
C-reactive protein abnormal | 21.42 | 9.92 | 9 | 81650 | 27800 | 50495665 |
Swollen tongue | 21.17 | 9.92 | 97 | 81562 | 28533 | 50494932 |
Sensitivity to weather change | 20.96 | 9.92 | 36 | 81623 | 5965 | 50517500 |
Product quality issue | 20.95 | 9.92 | 102 | 81557 | 30756 | 50492709 |
Asphyxia | 20.88 | 9.92 | 34 | 81625 | 5393 | 50518072 |
Diverticulum | 20.70 | 9.92 | 50 | 81609 | 10564 | 50512901 |
Bacterial disease carrier | 20.49 | 9.92 | 14 | 81645 | 797 | 50522668 |
Throat tightness | 20.42 | 9.92 | 77 | 81582 | 20770 | 50502695 |
Nasal discharge discolouration | 20.39 | 9.92 | 18 | 81641 | 1496 | 50521969 |
Device malfunction | 20.23 | 9.92 | 62 | 81597 | 15059 | 50508406 |
Maternal exposure during pregnancy | 20.14 | 9.92 | 163 | 81496 | 159615 | 50363850 |
Neoplasm progression | 20.07 | 9.92 | 11 | 81648 | 29146 | 50494319 |
Alternaria infection | 19.96 | 9.92 | 9 | 81650 | 224 | 50523241 |
Haematochezia | 19.77 | 9.92 | 121 | 81538 | 39761 | 50483704 |
Musculoskeletal stiffness | 19.63 | 9.92 | 124 | 81535 | 128357 | 50395108 |
Drug level below therapeutic | 19.49 | 9.92 | 27 | 81632 | 3713 | 50519752 |
Osteomyelitis | 19.31 | 9.92 | 6 | 81653 | 22347 | 50501118 |
Kyphosis | 19.15 | 9.92 | 21 | 81638 | 2274 | 50521191 |
Sedation | 19.05 | 9.92 | 13 | 81646 | 30597 | 50492868 |
Diarrhoea | 19.01 | 9.92 | 767 | 80892 | 587709 | 49935756 |
Mitochondrial neurogastrointestinal encephalopathy | 18.96 | 9.92 | 4 | 81655 | 4 | 50523461 |
Oesophageal candidiasis | 18.83 | 9.92 | 31 | 81628 | 4963 | 50518502 |
Catarrh | 18.76 | 9.92 | 10 | 81649 | 361 | 50523104 |
Pharyngeal oedema | 18.57 | 9.92 | 55 | 81604 | 13110 | 50510355 |
Ligament pain | 18.40 | 9.92 | 8 | 81651 | 182 | 50523283 |
Vomiting | 18.40 | 9.92 | 585 | 81074 | 460173 | 50063292 |
Rales | 18.40 | 9.92 | 46 | 81613 | 9932 | 50513533 |
Malaise | 18.39 | 9.92 | 688 | 80971 | 334844 | 50188621 |
Cardio-respiratory arrest | 18.36 | 9.92 | 37 | 81622 | 53855 | 50469610 |
Rhinitis | 18.27 | 9.92 | 41 | 81618 | 8260 | 50515205 |
Rectal prolapse | 18.18 | 9.92 | 18 | 81641 | 1731 | 50521734 |
Sprue-like enteropathy | 18.09 | 9.92 | 11 | 81648 | 512 | 50522953 |
Tracheostomy infection | 18.07 | 9.92 | 5 | 81654 | 26 | 50523439 |
Suicide attempt | 18.07 | 9.92 | 35 | 81624 | 51697 | 50471768 |
Cognitive disorder | 18.03 | 9.92 | 27 | 81632 | 44096 | 50479369 |
Type IV hypersensitivity reaction | 17.80 | 9.92 | 21 | 81638 | 2461 | 50521004 |
Acquired diaphragmatic eventration | 17.80 | 9.92 | 10 | 81649 | 401 | 50523064 |
Tachycardia | 17.67 | 9.92 | 242 | 81417 | 99521 | 50423944 |
Nocturnal dyspnoea | 17.67 | 9.92 | 14 | 81645 | 1002 | 50522463 |
Colitis microscopic | 17.59 | 9.92 | 35 | 81624 | 6485 | 50516980 |
Sinus congestion | 17.50 | 9.92 | 56 | 81603 | 13915 | 50509550 |
Fatigue | 17.14 | 9.92 | 951 | 80708 | 706650 | 49816815 |
Lip infection | 17.09 | 9.92 | 6 | 81653 | 75 | 50523390 |
Otorrhoea | 17.05 | 9.92 | 15 | 81644 | 1241 | 50522224 |
Impaired quality of life | 16.94 | 9.92 | 33 | 81626 | 6023 | 50517442 |
Anaemia | 16.92 | 9.92 | 296 | 81363 | 252160 | 50271305 |
Secretion discharge | 16.87 | 9.92 | 44 | 81615 | 9747 | 50513718 |
Sinus operation | 16.79 | 9.92 | 17 | 81642 | 1679 | 50521786 |
Faecal calprotectin increased | 16.74 | 9.92 | 19 | 81640 | 2136 | 50521329 |
Gastrointestinal disorder | 16.66 | 9.92 | 87 | 81572 | 94369 | 50429096 |
Smoke sensitivity | 16.65 | 9.92 | 9 | 81650 | 334 | 50523131 |
Encephalopathy | 16.50 | 9.92 | 18 | 81641 | 33693 | 50489772 |
Pulmonary function test abnormal | 16.50 | 9.92 | 15 | 81644 | 1296 | 50522169 |
Hyperplastic cholecystopathy | 16.47 | 9.92 | 6 | 81653 | 84 | 50523381 |
Female reproductive neoplasm | 16.46 | 9.92 | 5 | 81654 | 38 | 50523427 |
Oligoarthritis | 16.42 | 9.92 | 8 | 81651 | 238 | 50523227 |
Haemoglobin decreased | 16.39 | 9.92 | 129 | 81530 | 127087 | 50396378 |
Metastases to liver | 16.32 | 9.92 | 6 | 81653 | 20098 | 50503367 |
Blood immunoglobulin G decreased | 16.28 | 9.92 | 18 | 81641 | 1967 | 50521498 |
Viral infection | 16.16 | 9.92 | 93 | 81566 | 29893 | 50493572 |
Increased bronchial secretion | 16.09 | 9.92 | 16 | 81643 | 1546 | 50521919 |
Small intestinal stenosis | 16.05 | 9.92 | 10 | 81649 | 486 | 50522979 |
Dyslipidaemia | 15.99 | 9.92 | 32 | 81627 | 5956 | 50517509 |
Mucosal inflammation | 15.98 | 9.92 | 25 | 81634 | 40117 | 50483348 |
Incorrect dose administered | 15.91 | 9.92 | 133 | 81526 | 48281 | 50475184 |
Pulmonary mass | 15.83 | 9.92 | 66 | 81593 | 18639 | 50504826 |
Leukopenia | 15.71 | 9.92 | 56 | 81603 | 67472 | 50455993 |
Throat clearing | 15.65 | 9.92 | 14 | 81645 | 1184 | 50522281 |
Nasal oedema | 15.65 | 9.92 | 12 | 81647 | 818 | 50522647 |
Dyspnoea at rest | 15.62 | 9.92 | 24 | 81635 | 3623 | 50519842 |
Terminal insomnia | 15.62 | 9.92 | 11 | 81648 | 658 | 50522807 |
Eczema impetiginous | 15.52 | 9.92 | 4 | 81655 | 15 | 50523450 |
Tremor | 15.46 | 9.92 | 266 | 81393 | 114637 | 50408828 |
Tachypnoea | 15.25 | 9.92 | 55 | 81604 | 14522 | 50508943 |
Cryptosporidiosis infection | 15.18 | 9.92 | 8 | 81651 | 282 | 50523183 |
Aspirin-exacerbated respiratory disease | 15.10 | 9.92 | 12 | 81647 | 862 | 50522603 |
Endometriosis | 14.97 | 9.92 | 25 | 81634 | 4050 | 50519415 |
Abdominal rigidity | 14.93 | 9.92 | 16 | 81643 | 1688 | 50521777 |
Cytomegalovirus infection | 14.90 | 9.92 | 63 | 81596 | 17899 | 50505566 |
Post viral fatigue syndrome | 14.87 | 9.92 | 8 | 81651 | 294 | 50523171 |
Red blood cell sedimentation rate abnormal | 14.83 | 9.92 | 4 | 81655 | 16339 | 50507126 |
Liver injury | 14.83 | 9.92 | 11 | 81648 | 24795 | 50498670 |
Laryngeal oedema | 14.70 | 9.92 | 28 | 81631 | 5025 | 50518440 |
Lung opacity | 14.66 | 9.92 | 17 | 81642 | 1956 | 50521509 |
Hypocalcaemia | 14.64 | 9.92 | 13 | 81646 | 26803 | 50496662 |
Anal fistula | 14.60 | 9.92 | 20 | 81639 | 2722 | 50520743 |
Infection | 14.58 | 9.92 | 194 | 81465 | 172760 | 50350705 |
Defaecation urgency | 14.48 | 9.92 | 21 | 81638 | 3012 | 50520453 |
Aspiration | 14.32 | 9.92 | 40 | 81619 | 9224 | 50514241 |
Coprolalia | 14.27 | 9.92 | 4 | 81655 | 22 | 50523443 |
Rectal tenesmus | 14.27 | 9.92 | 9 | 81650 | 447 | 50523018 |
Weight gain poor | 14.27 | 9.92 | 11 | 81648 | 756 | 50522709 |
Graft versus host disease | 14.18 | 9.92 | 31 | 81628 | 6135 | 50517330 |
Hysterectomy | 14.15 | 9.92 | 36 | 81623 | 7854 | 50515611 |
Cardiac disorder | 14.08 | 9.92 | 118 | 81541 | 42861 | 50480604 |
Atopy | 13.93 | 9.92 | 7 | 81652 | 223 | 50523242 |
Abscess intestinal | 13.86 | 9.92 | 14 | 81645 | 1379 | 50522086 |
Stridor | 13.78 | 9.92 | 21 | 81638 | 3148 | 50520317 |
Mucous stools | 13.72 | 9.92 | 20 | 81639 | 2882 | 50520583 |
Cushing's syndrome | 13.63 | 9.92 | 10 | 81649 | 638 | 50522827 |
Metastases to bone | 13.58 | 9.92 | 6 | 81653 | 17989 | 50505476 |
Pulmonary artery stenosis congenital | 13.49 | 9.92 | 7 | 81652 | 239 | 50523226 |
Oedema peripheral | 13.48 | 9.92 | 342 | 81317 | 157619 | 50365846 |
Distal intestinal obstruction syndrome | 13.46 | 9.92 | 8 | 81651 | 357 | 50523108 |
Nephrectomy | 13.45 | 9.92 | 11 | 81648 | 824 | 50522641 |
Norovirus infection | 13.43 | 9.92 | 7 | 81652 | 241 | 50523224 |
Abscess | 13.39 | 9.92 | 52 | 81607 | 14220 | 50509245 |
Bronchospasm paradoxical | 13.35 | 9.92 | 5 | 81654 | 76 | 50523389 |
Device ineffective | 13.24 | 9.92 | 6 | 81653 | 151 | 50523314 |
Weight fluctuation | 13.23 | 9.92 | 33 | 81626 | 7115 | 50516350 |
Myelodysplastic syndrome | 13.18 | 9.92 | 4 | 81655 | 15128 | 50508337 |
Large intestinal stenosis | 13.07 | 9.92 | 15 | 81644 | 1707 | 50521758 |
Haematemesis | 13.04 | 9.92 | 83 | 81576 | 27642 | 50495823 |
Plasma cell myeloma | 12.96 | 9.92 | 19 | 81640 | 31303 | 50492162 |
Device failure | 12.95 | 9.92 | 28 | 81631 | 5500 | 50517965 |
Generalised tonic-clonic seizure | 12.93 | 9.92 | 14 | 81645 | 26296 | 50497169 |
Tooth disorder | 12.93 | 9.92 | 12 | 81647 | 24216 | 50499249 |
Growth retardation | 12.92 | 9.92 | 12 | 81647 | 1066 | 50522399 |
Infrapatellar fat pad inflammation | 12.89 | 9.92 | 6 | 81653 | 161 | 50523304 |
Drug specific antibody present | 12.82 | 9.92 | 21 | 81638 | 3347 | 50520118 |
Bowel movement irregularity | 12.82 | 9.92 | 23 | 81636 | 3945 | 50519520 |
Respiratory rate increased | 12.81 | 9.92 | 44 | 81615 | 11341 | 50512124 |
Knee arthroplasty | 12.74 | 9.92 | 24 | 81635 | 35822 | 50487643 |
Respiratory tract congestion | 12.73 | 9.92 | 51 | 81608 | 14148 | 50509317 |
Paraesthesia oral | 12.69 | 9.92 | 46 | 81613 | 12175 | 50511290 |
Skin dystrophy | 12.57 | 9.92 | 4 | 81655 | 36 | 50523429 |
Bronchitis bacterial | 12.53 | 9.92 | 10 | 81649 | 723 | 50522742 |
Hypersensitivity pneumonitis | 12.46 | 9.92 | 17 | 81642 | 2305 | 50521160 |
Ageusia | 12.37 | 9.92 | 44 | 81615 | 11539 | 50511926 |
Faeces soft | 12.34 | 9.92 | 23 | 81636 | 4061 | 50519404 |
Small intestinal obstruction | 12.29 | 9.92 | 55 | 81604 | 16013 | 50507452 |
Congenital naevus | 12.27 | 9.92 | 6 | 81653 | 180 | 50523285 |
Congenital tricuspid valve incompetence | 12.23 | 9.92 | 5 | 81654 | 97 | 50523368 |
Delayed puberty | 12.19 | 9.92 | 5 | 81654 | 98 | 50523367 |
Gingival hypertrophy | 12.12 | 9.92 | 13 | 81646 | 1373 | 50522092 |
Infusion site swelling | 12.11 | 9.92 | 32 | 81627 | 7144 | 50516321 |
Aural polyp | 12.09 | 9.92 | 5 | 81654 | 100 | 50523365 |
Disease recurrence | 11.97 | 9.92 | 64 | 81595 | 20017 | 50503448 |
Injection site reaction | 11.96 | 9.92 | 41 | 81618 | 49991 | 50473474 |
Perfume sensitivity | 11.93 | 9.92 | 9 | 81650 | 599 | 50522866 |
Intestinal fistula | 11.91 | 9.92 | 10 | 81649 | 777 | 50522688 |
Pallor | 11.89 | 9.92 | 71 | 81588 | 23128 | 50500337 |
Clostridium difficile infection | 11.87 | 9.92 | 76 | 81583 | 25363 | 50498102 |
Bronchial hyperreactivity | 11.84 | 9.92 | 13 | 81646 | 1409 | 50522056 |
Myalgia | 11.76 | 9.92 | 273 | 81386 | 124046 | 50399419 |
Renal impairment | 11.56 | 9.92 | 73 | 81586 | 75588 | 50447877 |
Sputum culture | 11.53 | 9.92 | 5 | 81654 | 113 | 50523352 |
Blood pressure systolic | 11.47 | 9.92 | 4 | 81655 | 49 | 50523416 |
Arrhythmia | 11.41 | 9.92 | 92 | 81567 | 33040 | 50490425 |
Ear pruritus | 11.35 | 9.92 | 17 | 81642 | 2509 | 50520956 |
Allergy to animal | 11.34 | 9.92 | 10 | 81649 | 830 | 50522635 |
Sinus pain | 11.30 | 9.92 | 16 | 81643 | 2245 | 50521220 |
Diabetes mellitus | 11.30 | 9.92 | 125 | 81534 | 48908 | 50474557 |
Photosensitivity reaction | 11.27 | 9.92 | 46 | 81613 | 12865 | 50510600 |
Product taste abnormal | 11.27 | 9.92 | 14 | 81645 | 1731 | 50521734 |
Hyponatraemia | 11.24 | 9.92 | 100 | 81559 | 96039 | 50427426 |
Product use in unapproved indication | 11.16 | 9.92 | 255 | 81404 | 115564 | 50407901 |
Condition aggravated | 11.14 | 9.92 | 586 | 81073 | 296472 | 50226993 |
Collateral circulation | 11.11 | 9.92 | 3 | 81656 | 14 | 50523451 |
Steroid dependence | 11.09 | 9.92 | 7 | 81652 | 348 | 50523117 |
Type 2 diabetes mellitus | 11.06 | 9.92 | 94 | 81565 | 34281 | 50489184 |
Adenovirus infection | 11.06 | 9.92 | 19 | 81640 | 3149 | 50520316 |
Anal abscess | 11.02 | 9.92 | 21 | 81638 | 3770 | 50519695 |
Sacroiliitis | 11.00 | 9.92 | 17 | 81642 | 2580 | 50520885 |
Language disorder | 11.00 | 9.92 | 14 | 81645 | 1774 | 50521691 |
Kussmaul respiration | 10.97 | 9.92 | 6 | 81653 | 228 | 50523237 |
Mitochondrial cytopathy | 10.95 | 9.92 | 6 | 81653 | 229 | 50523236 |
Urinary tract discomfort | 10.95 | 9.92 | 6 | 81653 | 229 | 50523236 |
Gastrointestinal scarring | 10.92 | 9.92 | 6 | 81653 | 230 | 50523235 |
Granulomatosis with polyangiitis | 10.92 | 9.92 | 14 | 81645 | 1786 | 50521679 |
Drug level decreased | 10.89 | 9.92 | 29 | 81630 | 6504 | 50516961 |
Red blood cell count decreased | 10.88 | 9.92 | 24 | 81635 | 33811 | 50489654 |
Hepatotoxicity | 10.80 | 9.92 | 17 | 81642 | 27209 | 50496256 |
Incorrect route of product administration | 10.79 | 9.92 | 59 | 81600 | 18607 | 50504858 |
Pulmonary contusion | 10.78 | 9.92 | 3 | 81656 | 16 | 50523449 |
Left ventricular failure | 10.75 | 9.92 | 24 | 81635 | 4817 | 50518648 |
Feeling jittery | 10.74 | 9.92 | 41 | 81618 | 11119 | 50512346 |
Bronchial wall thickening | 10.70 | 9.92 | 10 | 81649 | 895 | 50522570 |
Behaviour disorder | 10.67 | 9.92 | 16 | 81643 | 2364 | 50521101 |
Symptom recurrence | 10.65 | 9.92 | 9 | 81650 | 705 | 50522760 |
Type I hypersensitivity | 10.65 | 9.92 | 16 | 81643 | 2369 | 50521096 |
Tongue blistering | 10.60 | 9.92 | 12 | 81647 | 1346 | 50522119 |
Drug withdrawal syndrome | 10.59 | 9.92 | 15 | 81644 | 25066 | 50498399 |
Nasal discomfort | 10.59 | 9.92 | 21 | 81638 | 3883 | 50519582 |
Tendon pain | 10.58 | 9.92 | 18 | 81641 | 2960 | 50520505 |
Skin atrophy | 10.52 | 9.92 | 22 | 81637 | 4223 | 50519242 |
Stenotrophomonas test positive | 10.48 | 9.92 | 3 | 81656 | 18 | 50523447 |
Laryngitis fungal | 10.48 | 9.92 | 5 | 81654 | 142 | 50523323 |
Hyperglycaemia | 10.40 | 9.92 | 97 | 81562 | 36308 | 50487157 |
Forced vital capacity decreased | 10.37 | 9.92 | 10 | 81649 | 931 | 50522534 |
Bone erosion | 10.35 | 9.92 | 3 | 81656 | 11684 | 50511781 |
Herpes zoster oticus | 10.34 | 9.92 | 6 | 81653 | 256 | 50523209 |
Cryptococcal meningoencephalitis | 10.33 | 9.92 | 4 | 81655 | 67 | 50523398 |
Blood glucose increased | 10.30 | 9.92 | 70 | 81589 | 71254 | 50452211 |
Functional residual capacity decreased | 10.27 | 9.92 | 4 | 81655 | 68 | 50523397 |
Dermatitis contact | 10.24 | 9.92 | 34 | 81625 | 8612 | 50514853 |
Depressed level of consciousness | 10.23 | 9.92 | 46 | 81613 | 51907 | 50471558 |
Rash maculo-papular | 10.22 | 9.92 | 17 | 81642 | 26624 | 50496841 |
Cyanosis | 10.17 | 9.92 | 50 | 81609 | 15134 | 50508331 |
Faeces discoloured | 10.03 | 9.92 | 52 | 81607 | 16072 | 50507393 |
Tricuspid valve incompetence | 9.99 | 9.92 | 44 | 81615 | 12726 | 50510739 |
Chest pain | 9.98 | 9.92 | 364 | 81295 | 176518 | 50346947 |
Cross sensitivity reaction | 9.94 | 9.92 | 14 | 81645 | 1955 | 50521510 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 694.56 | 10.24 | 506 | 45429 | 33343 | 29495249 |
Wheezing | 316.18 | 10.24 | 320 | 45615 | 32920 | 29495672 |
Dyspnoea | 279.86 | 10.24 | 1122 | 44813 | 325610 | 29202982 |
Cough | 192.03 | 10.24 | 529 | 45406 | 126198 | 29402394 |
Productive cough | 130.52 | 10.24 | 199 | 45736 | 31060 | 29497532 |
Colitis ulcerative | 128.78 | 10.24 | 127 | 45808 | 12642 | 29515950 |
Chronic obstructive pulmonary disease | 126.96 | 10.24 | 228 | 45707 | 40727 | 29487865 |
Toxicity to various agents | 126.19 | 10.24 | 56 | 45879 | 173605 | 29354987 |
Chest discomfort | 122.62 | 10.24 | 240 | 45695 | 45743 | 29482849 |
Frequent bowel movements | 116.42 | 10.24 | 104 | 45831 | 9135 | 29519457 |
Growth failure | 108.54 | 10.24 | 24 | 45911 | 38 | 29528554 |
Completed suicide | 101.36 | 10.24 | 11 | 45924 | 90235 | 29438357 |
Drug abuse | 94.29 | 10.24 | 8 | 45927 | 79875 | 29448717 |
Eosinophilic granulomatosis with polyangiitis | 90.94 | 10.24 | 44 | 45891 | 1342 | 29527250 |
Acute kidney injury | 89.52 | 10.24 | 173 | 45762 | 265094 | 29263498 |
Bronchiectasis | 80.74 | 10.24 | 73 | 45862 | 6512 | 29522080 |
Condition aggravated | 77.16 | 10.24 | 438 | 45497 | 145857 | 29382735 |
Night sweats | 76.83 | 10.24 | 105 | 45830 | 14827 | 29513765 |
Cushingoid | 75.18 | 10.24 | 47 | 45888 | 2391 | 29526201 |
Adrenal suppression | 75.02 | 10.24 | 29 | 45906 | 503 | 29528089 |
Therapeutic product effect incomplete | 72.61 | 10.24 | 177 | 45758 | 39128 | 29489464 |
Sleep disorder due to a general medical condition | 71.19 | 10.24 | 50 | 45885 | 3096 | 29525496 |
Bronchospasm | 69.29 | 10.24 | 80 | 45855 | 9529 | 29519063 |
Loss of personal independence in daily activities | 66.82 | 10.24 | 132 | 45803 | 25308 | 29503284 |
Blood immunoglobulin E increased | 66.33 | 10.24 | 40 | 45895 | 1907 | 29526685 |
Faecal calprotectin increased | 63.56 | 10.24 | 36 | 45899 | 1525 | 29527067 |
Spirometry abnormal | 62.02 | 10.24 | 23 | 45912 | 354 | 29528238 |
Nasal polyps | 61.97 | 10.24 | 37 | 45898 | 1732 | 29526860 |
Colitis | 59.08 | 10.24 | 142 | 45793 | 31106 | 29497486 |
Mycotic allergy | 58.16 | 10.24 | 20 | 45915 | 244 | 29528348 |
Death | 57.59 | 10.24 | 305 | 45630 | 341779 | 29186813 |
Weight decreased | 55.12 | 10.24 | 412 | 45523 | 150493 | 29378099 |
Ileal stenosis | 54.56 | 10.24 | 30 | 45905 | 1199 | 29527393 |
Dust allergy | 52.82 | 10.24 | 22 | 45913 | 467 | 29528125 |
Mite allergy | 47.28 | 10.24 | 18 | 45917 | 299 | 29528293 |
Cushing's syndrome | 46.57 | 10.24 | 19 | 45916 | 382 | 29528210 |
Circumstance or information capable of leading to medication error | 46.04 | 10.24 | 29 | 45906 | 1495 | 29527097 |
Full blood count abnormal | 44.47 | 10.24 | 82 | 45853 | 14931 | 29513661 |
Impaired quality of life | 44.41 | 10.24 | 35 | 45900 | 2584 | 29526008 |
Mucous stools | 43.03 | 10.24 | 25 | 45910 | 1112 | 29527480 |
Off label use | 42.93 | 10.24 | 680 | 45255 | 300120 | 29228472 |
Sinusitis | 42.83 | 10.24 | 134 | 45801 | 34216 | 29494376 |
Neutropenia | 42.49 | 10.24 | 88 | 45847 | 131623 | 29396969 |
Breath sounds abnormal | 42 | 10.24 | 47 | 45888 | 5410 | 29523182 |
Bronchiolitis | 40.76 | 10.24 | 34 | 45901 | 2721 | 29525871 |
Conjunctivitis allergic | 40.74 | 10.24 | 20 | 45915 | 630 | 29527962 |
Product use issue | 40.64 | 10.24 | 173 | 45762 | 51271 | 29477321 |
Obstructive airways disorder | 40.24 | 10.24 | 66 | 45869 | 10950 | 29517642 |
Lung diffusion test decreased | 39.62 | 10.24 | 19 | 45916 | 568 | 29528024 |
Proctitis | 39.60 | 10.24 | 30 | 45905 | 2089 | 29526503 |
Herpes zoster meningoencephalitis | 39.02 | 10.24 | 15 | 45920 | 256 | 29528336 |
Dyspnoea at rest | 38.17 | 10.24 | 35 | 45900 | 3179 | 29525413 |
Steroid dependence | 37.64 | 10.24 | 15 | 45920 | 283 | 29528309 |
Aphthous ulcer | 36.51 | 10.24 | 38 | 45897 | 4030 | 29524562 |
Febrile neutropenia | 34.51 | 10.24 | 77 | 45858 | 112163 | 29416429 |
Blood immunoglobulin E decreased | 34.22 | 10.24 | 9 | 45926 | 39 | 29528553 |
Cyanosis | 33.95 | 10.24 | 62 | 45873 | 11205 | 29517387 |
Adrenal insufficiency | 32.03 | 10.24 | 60 | 45875 | 11054 | 29517538 |
Graft versus host disease | 31.60 | 10.24 | 55 | 45880 | 9573 | 29519019 |
Asphyxia | 31.39 | 10.24 | 40 | 45895 | 5275 | 29523317 |
Infective pulmonary exacerbation of cystic fibrosis | 30.79 | 10.24 | 43 | 45892 | 6193 | 29522399 |
Pneumonia | 30.76 | 10.24 | 681 | 45254 | 319491 | 29209101 |
Nasal congestion | 30.66 | 10.24 | 81 | 45854 | 18798 | 29509794 |
Sputum discoloured | 30.55 | 10.24 | 44 | 45891 | 6519 | 29522073 |
Eye swelling | 30.45 | 10.24 | 51 | 45884 | 8606 | 29519986 |
Intentional device misuse | 30.17 | 10.24 | 11 | 45924 | 161 | 29528431 |
Disease progression | 29.67 | 10.24 | 51 | 45884 | 81865 | 29446727 |
Heart rate increased | 28.50 | 10.24 | 128 | 45807 | 38810 | 29489782 |
Forced expiratory volume decreased | 28.39 | 10.24 | 28 | 45907 | 2785 | 29525807 |
Mycobacterium test positive | 27.50 | 10.24 | 13 | 45922 | 376 | 29528216 |
Intestinal fistula | 27.33 | 10.24 | 17 | 45918 | 857 | 29527735 |
Respiratory tract infection | 27.32 | 10.24 | 69 | 45866 | 15582 | 29513010 |
Upper-airway cough syndrome | 26.85 | 10.24 | 28 | 45907 | 2975 | 29525617 |
Colitis microscopic | 26.58 | 10.24 | 22 | 45913 | 1741 | 29526851 |
Therapeutic product effect decreased | 26.38 | 10.24 | 103 | 45832 | 29348 | 29499244 |
Lung disorder | 26.24 | 10.24 | 105 | 45830 | 30257 | 29498335 |
Nasal obstruction | 25.94 | 10.24 | 14 | 45921 | 539 | 29528053 |
Neuropathy peripheral | 25.92 | 10.24 | 44 | 45891 | 70983 | 29457609 |
Allergy to animal | 25.76 | 10.24 | 11 | 45924 | 249 | 29528343 |
Foetal distress syndrome | 25.25 | 10.24 | 17 | 45918 | 982 | 29527610 |
Delayed puberty | 25.13 | 10.24 | 10 | 45925 | 188 | 29528404 |
Thrombocytopenia | 24.39 | 10.24 | 117 | 45818 | 134706 | 29393886 |
Musculoskeletal stiffness | 24.26 | 10.24 | 14 | 45921 | 37444 | 29491148 |
Procedural pneumothorax | 24.18 | 10.24 | 7 | 45928 | 46 | 29528546 |
Intentional overdose | 24.11 | 10.24 | 15 | 45920 | 38513 | 29490079 |
Lower respiratory tract infection | 23.99 | 10.24 | 93 | 45842 | 26409 | 29502183 |
Throat clearing | 23.98 | 10.24 | 10 | 45925 | 213 | 29528379 |
Bronchitis | 23.90 | 10.24 | 117 | 45818 | 36751 | 29491841 |
Rhinitis | 23.67 | 10.24 | 33 | 45902 | 4745 | 29523847 |
Eye infection fungal | 23.40 | 10.24 | 11 | 45924 | 314 | 29528278 |
Apoptosis | 23.35 | 10.24 | 10 | 45925 | 228 | 29528364 |
Fungal oesophagitis | 23.31 | 10.24 | 11 | 45924 | 317 | 29528275 |
Botulism | 23.03 | 10.24 | 9 | 45926 | 161 | 29528431 |
Fall | 22.95 | 10.24 | 171 | 45764 | 177007 | 29351585 |
Nasopharyngitis | 22.92 | 10.24 | 165 | 45770 | 59500 | 29469092 |
Periumbilical abscess | 22.77 | 10.24 | 7 | 45928 | 58 | 29528534 |
Hypotension | 22.67 | 10.24 | 193 | 45742 | 194161 | 29334431 |
Malignant neoplasm progression | 22.42 | 10.24 | 51 | 45884 | 73808 | 29454784 |
Gastrointestinal anastomotic leak | 22.30 | 10.24 | 11 | 45924 | 350 | 29528242 |
Granuloma | 22.08 | 10.24 | 23 | 45912 | 2441 | 29526151 |
Platelet count decreased | 21.88 | 10.24 | 86 | 45849 | 104586 | 29424006 |
Lactic acidosis | 21.52 | 10.24 | 10 | 45925 | 30237 | 29498355 |
Eosinophil count increased | 21.51 | 10.24 | 40 | 45895 | 7329 | 29521263 |
Intestinal stenosis | 21.33 | 10.24 | 20 | 45915 | 1868 | 29526724 |
Gastrooesophageal reflux disease | 21.17 | 10.24 | 101 | 45834 | 31395 | 29497197 |
Dyspnoea exertional | 21.00 | 10.24 | 112 | 45823 | 36378 | 29492214 |
Tracheitis | 20.99 | 10.24 | 13 | 45922 | 650 | 29527942 |
Respiratory distress | 20.89 | 10.24 | 102 | 45833 | 32004 | 29496588 |
Hypothalamic pituitary adrenal axis suppression | 20.84 | 10.24 | 8 | 45927 | 136 | 29528456 |
Blood pressure increased | 20.70 | 10.24 | 190 | 45745 | 73613 | 29454979 |
Inappropriate schedule of product administration | 20.69 | 10.24 | 129 | 45806 | 44343 | 29484249 |
Product use in unapproved indication | 20.63 | 10.24 | 216 | 45719 | 86659 | 29441933 |
Activated partial thromboplastin time shortened | 20.46 | 10.24 | 11 | 45924 | 420 | 29528172 |
White blood cell count decreased | 20.43 | 10.24 | 64 | 45871 | 83298 | 29445294 |
Oxygen saturation decreased | 20.07 | 10.24 | 129 | 45806 | 44808 | 29483784 |
Retinal ischaemia | 20.05 | 10.24 | 10 | 45925 | 326 | 29528266 |
Respiratory disorder | 20.02 | 10.24 | 65 | 45870 | 16918 | 29511674 |
Graft versus host disease in gastrointestinal tract | 20.00 | 10.24 | 25 | 45910 | 3233 | 29525359 |
Gastrointestinal inflammation | 19.95 | 10.24 | 24 | 45911 | 2984 | 29525608 |
Relapsing fever | 19.93 | 10.24 | 8 | 45927 | 154 | 29528438 |
Neutrophil count decreased | 19.87 | 10.24 | 23 | 45912 | 43544 | 29485048 |
Anaemia | 19.82 | 10.24 | 208 | 45727 | 200743 | 29327849 |
Skin striae | 19.81 | 10.24 | 11 | 45924 | 448 | 29528144 |
Rotavirus infection | 19.59 | 10.24 | 10 | 45925 | 343 | 29528249 |
Penile erythema | 19.46 | 10.24 | 8 | 45927 | 164 | 29528428 |
Emphysema | 19.25 | 10.24 | 42 | 45893 | 8629 | 29519963 |
Cerebral microangiopathy | 19.24 | 10.24 | 8 | 45927 | 169 | 29528423 |
Drug ineffective | 19.09 | 10.24 | 716 | 45219 | 362454 | 29166138 |
Blood pressure fluctuation | 18.99 | 10.24 | 71 | 45864 | 19823 | 29508769 |
Rash erythematous | 18.98 | 10.24 | 75 | 45860 | 21487 | 29507105 |
Ear infection | 18.86 | 10.24 | 40 | 45895 | 8060 | 29520532 |
Rhinovirus infection | 18.67 | 10.24 | 24 | 45911 | 3192 | 29525400 |
Blood pressure systolic increased | 18.54 | 10.24 | 63 | 45872 | 16782 | 29511810 |
Gastrointestinal wall thickening | 18.50 | 10.24 | 15 | 45920 | 1153 | 29527439 |
Crohn's disease | 18.33 | 10.24 | 23 | 45912 | 2986 | 29525606 |
Osteoporosis | 18.30 | 10.24 | 47 | 45888 | 10722 | 29517870 |
Oedema mouth | 18.14 | 10.24 | 15 | 45920 | 1186 | 29527406 |
CADASIL | 17.93 | 10.24 | 6 | 45929 | 67 | 29528525 |
Rhonchi | 17.84 | 10.24 | 17 | 45918 | 1621 | 29526971 |
Carotid arteriosclerosis | 17.74 | 10.24 | 16 | 45919 | 1422 | 29527170 |
Intestinal obstruction | 17.74 | 10.24 | 68 | 45867 | 19209 | 29509383 |
Electrocardiogram QT prolonged | 17.67 | 10.24 | 18 | 45917 | 36119 | 29492473 |
Magnetic resonance imaging spinal abnormal | 17.61 | 10.24 | 6 | 45929 | 71 | 29528521 |
Tracheal haemorrhage | 17.54 | 10.24 | 10 | 45925 | 429 | 29528163 |
Drug level below therapeutic | 17.54 | 10.24 | 27 | 45908 | 4244 | 29524348 |
Nephrectomy | 17.48 | 10.24 | 12 | 45923 | 716 | 29527876 |
Varicella zoster virus infection | 17.46 | 10.24 | 16 | 45919 | 1452 | 29527140 |
Visual evoked potentials abnormal | 17.24 | 10.24 | 6 | 45929 | 76 | 29528516 |
Nasal turbinate hypertrophy | 17.10 | 10.24 | 6 | 45929 | 78 | 29528514 |
Blood creatinine increased | 17.10 | 10.24 | 71 | 45864 | 85031 | 29443561 |
Adrenocortical insufficiency acute | 16.90 | 10.24 | 15 | 45920 | 1305 | 29527287 |
Pouchitis | 16.87 | 10.24 | 11 | 45924 | 602 | 29527990 |
Anosmia | 16.80 | 10.24 | 18 | 45917 | 1973 | 29526619 |
Cataract | 16.69 | 10.24 | 74 | 45861 | 22304 | 29506288 |
Suicide attempt | 16.67 | 10.24 | 17 | 45918 | 34093 | 29494499 |
Pulmonary function test decreased | 16.65 | 10.24 | 26 | 45909 | 4137 | 29524455 |
Increased upper airway secretion | 16.57 | 10.24 | 16 | 45919 | 1550 | 29527042 |
Reversible airways obstruction | 16.56 | 10.24 | 8 | 45927 | 243 | 29528349 |
Nausea | 16.39 | 10.24 | 334 | 45601 | 288921 | 29239671 |
Adrenal cortex necrosis | 16.35 | 10.24 | 4 | 45931 | 12 | 29528580 |
Mucosal inflammation | 16.31 | 10.24 | 15 | 45920 | 31580 | 29497012 |
Pharyngitis streptococcal | 16.27 | 10.24 | 18 | 45917 | 2046 | 29526546 |
Product quality issue | 16.24 | 10.24 | 58 | 45877 | 15837 | 29512755 |
Anaphylactic reaction | 16.11 | 10.24 | 85 | 45850 | 27488 | 29501104 |
Hypercapnic coma | 16.09 | 10.24 | 7 | 45928 | 166 | 29528426 |
Bronchopulmonary aspergillosis allergic | 16.01 | 10.24 | 10 | 45925 | 508 | 29528084 |
Growth retardation | 15.98 | 10.24 | 16 | 45919 | 1620 | 29526972 |
Cardiogenic shock | 15.89 | 10.24 | 5 | 45930 | 19185 | 29509407 |
Dysbiosis | 15.72 | 10.24 | 9 | 45926 | 389 | 29528203 |
Delirium | 15.70 | 10.24 | 23 | 45912 | 39374 | 29489218 |
Central nervous system inflammation | 15.69 | 10.24 | 6 | 45929 | 101 | 29528491 |
Psychotic disorder | 15.65 | 10.24 | 6 | 45929 | 20348 | 29508244 |
Factor V Leiden mutation | 15.62 | 10.24 | 5 | 45930 | 48 | 29528544 |
Respiration abnormal | 15.56 | 10.24 | 20 | 45915 | 2660 | 29525932 |
Full blood count decreased | 15.50 | 10.24 | 3 | 45932 | 15989 | 29512603 |
Stomatitis | 15.45 | 10.24 | 21 | 45914 | 37092 | 29491500 |
Status asthmaticus | 15.42 | 10.24 | 8 | 45927 | 284 | 29528308 |
Leukopenia | 15.27 | 10.24 | 40 | 45895 | 55163 | 29473429 |
Haematochezia | 15.20 | 10.24 | 104 | 45831 | 36879 | 29491713 |
Sepsis | 15.17 | 10.24 | 145 | 45790 | 142537 | 29386055 |
Defaecation urgency | 15.09 | 10.24 | 16 | 45919 | 1733 | 29526859 |
Intentional product use issue | 14.88 | 10.24 | 115 | 45820 | 42383 | 29486209 |
Respiratory syncytial virus infection | 14.84 | 10.24 | 23 | 45912 | 3636 | 29524956 |
Drug reaction with eosinophilia and systemic symptoms | 14.79 | 10.24 | 13 | 45922 | 27979 | 29500613 |
Product substitution error | 14.74 | 10.24 | 4 | 45931 | 20 | 29528572 |
Peak expiratory flow rate decreased | 14.73 | 10.24 | 6 | 45929 | 120 | 29528472 |
Hypoventilation | 14.64 | 10.24 | 20 | 45915 | 2821 | 29525771 |
Necrotising retinitis | 14.63 | 10.24 | 11 | 45924 | 757 | 29527835 |
Hypercapnia | 14.53 | 10.24 | 23 | 45912 | 3703 | 29524889 |
Eosinophilic oesophagitis | 14.51 | 10.24 | 7 | 45928 | 212 | 29528380 |
Short-bowel syndrome | 14.45 | 10.24 | 7 | 45928 | 214 | 29528378 |
Dysarthria | 14.44 | 10.24 | 16 | 45919 | 30895 | 29497697 |
Rubber sensitivity | 14.42 | 10.24 | 6 | 45929 | 127 | 29528465 |
Laryngeal cryptococcosis | 14.33 | 10.24 | 3 | 45932 | 3 | 29528589 |
Precursor B-lymphoblastic lymphoma | 14.33 | 10.24 | 3 | 45932 | 3 | 29528589 |
Bronchial obstruction | 14.32 | 10.24 | 14 | 45921 | 1377 | 29527215 |
Saccadic eye movement | 14.29 | 10.24 | 6 | 45929 | 130 | 29528462 |
Gastroenteritis clostridial | 14.24 | 10.24 | 7 | 45928 | 221 | 29528371 |
Urinary tract infection | 14.14 | 10.24 | 61 | 45874 | 72293 | 29456299 |
Abdominal abscess | 14.08 | 10.24 | 23 | 45912 | 3801 | 29524791 |
Rhabdomyolysis | 13.98 | 10.24 | 48 | 45887 | 60760 | 29467832 |
Therapeutic response shortened | 13.97 | 10.24 | 26 | 45909 | 4765 | 29523827 |
Somnolence | 13.97 | 10.24 | 87 | 45848 | 93868 | 29434724 |
Nocardiosis | 13.94 | 10.24 | 21 | 45914 | 3239 | 29525353 |
Influenza | 13.93 | 10.24 | 112 | 45823 | 41769 | 29486823 |
Necrotising ulcerative gingivostomatitis | 13.91 | 10.24 | 5 | 45930 | 70 | 29528522 |
Cerebral artery embolism | 13.87 | 10.24 | 11 | 45924 | 819 | 29527773 |
Cortisol decreased | 13.86 | 10.24 | 11 | 45924 | 820 | 29527772 |
Aspergillus infection | 13.85 | 10.24 | 42 | 45893 | 10539 | 29518053 |
Nasal disorder | 13.84 | 10.24 | 14 | 45921 | 1435 | 29527157 |
Dermatitis contact | 13.84 | 10.24 | 20 | 45915 | 2972 | 29525620 |
Obstruction | 13.82 | 10.24 | 16 | 45919 | 1910 | 29526682 |
Abdominal adhesions | 13.74 | 10.24 | 13 | 45922 | 1228 | 29527364 |
Cardio-respiratory arrest | 13.74 | 10.24 | 37 | 45898 | 50564 | 29478028 |
Serotonin syndrome | 13.74 | 10.24 | 5 | 45930 | 17507 | 29511085 |
Drug level above therapeutic | 13.70 | 10.24 | 21 | 45914 | 3289 | 29525303 |
Cytomegalovirus colitis | 13.67 | 10.24 | 18 | 45917 | 2451 | 29526141 |
Body temperature decreased | 13.65 | 10.24 | 42 | 45893 | 10622 | 29517970 |
Oropharyngeal pain | 13.65 | 10.24 | 85 | 45850 | 29200 | 29499392 |
Bacterial toxaemia | 13.61 | 10.24 | 6 | 45929 | 147 | 29528445 |
Confusional state | 13.57 | 10.24 | 130 | 45805 | 127747 | 29400845 |
Throat irritation | 13.56 | 10.24 | 37 | 45898 | 8748 | 29519844 |
Plasma cell myeloma | 13.53 | 10.24 | 23 | 45912 | 37092 | 29491500 |
Cystic fibrosis | 13.50 | 10.24 | 14 | 45921 | 1478 | 29527114 |
Respiratory tract congestion | 13.49 | 10.24 | 27 | 45908 | 5222 | 29523370 |
Foreign body aspiration | 13.32 | 10.24 | 6 | 45929 | 155 | 29528437 |
Pneumonia adenoviral | 13.28 | 10.24 | 6 | 45929 | 156 | 29528436 |
Small airways disease | 13.25 | 10.24 | 4 | 45931 | 31 | 29528561 |
Gastrointestinal mucosa hyperaemia | 13.25 | 10.24 | 7 | 45928 | 258 | 29528334 |
Congenital hydronephrosis | 13.24 | 10.24 | 10 | 45925 | 693 | 29527899 |
Acute respiratory failure | 13.17 | 10.24 | 78 | 45857 | 26324 | 29502268 |
Oesophageal carcinoma recurrent | 13.12 | 10.24 | 3 | 45932 | 6 | 29528586 |
Astrovirus test positive | 13.12 | 10.24 | 3 | 45932 | 6 | 29528586 |
Rhinorrhoea | 13.03 | 10.24 | 67 | 45868 | 21452 | 29507140 |
Constipation | 13.00 | 10.24 | 114 | 45821 | 114046 | 29414546 |
Complicated appendicitis | 12.92 | 10.24 | 4 | 45931 | 34 | 29528558 |
Pancreatic cyst | 12.81 | 10.24 | 10 | 45925 | 728 | 29527864 |
Sleep disorder | 12.79 | 10.24 | 73 | 45862 | 24313 | 29504279 |
Sinus operation | 12.77 | 10.24 | 9 | 45926 | 560 | 29528032 |
Product monitoring error | 12.70 | 10.24 | 18 | 45917 | 2627 | 29525965 |
Asthmatic crisis | 12.69 | 10.24 | 8 | 45927 | 413 | 29528179 |
Product administered to patient of inappropriate age | 12.65 | 10.24 | 18 | 45917 | 2637 | 29525955 |
Pulmonary oedema | 12.57 | 10.24 | 30 | 45905 | 42705 | 29485887 |
Bronchial disorder | 12.55 | 10.24 | 12 | 45923 | 1149 | 29527443 |
Secretion discharge | 12.47 | 10.24 | 23 | 45912 | 4187 | 29524405 |
Double stranded DNA antibody positive | 12.40 | 10.24 | 6 | 45929 | 183 | 29528409 |
Overdose | 12.34 | 10.24 | 73 | 45862 | 79746 | 29448846 |
Proctalgia | 12.33 | 10.24 | 23 | 45912 | 4222 | 29524370 |
Liver disorder | 12.28 | 10.24 | 15 | 45920 | 27734 | 29500858 |
Stoma site abscess | 12.26 | 10.24 | 4 | 45931 | 41 | 29528551 |
Sputum increased | 12.17 | 10.24 | 15 | 45920 | 1912 | 29526680 |
Coma | 12.16 | 10.24 | 27 | 45908 | 39423 | 29489169 |
Lipid metabolism disorder | 12.14 | 10.24 | 7 | 45928 | 307 | 29528285 |
Tachypnoea | 12.05 | 10.24 | 51 | 45884 | 15064 | 29513528 |
Neuroleptic malignant syndrome | 12.02 | 10.24 | 5 | 45930 | 16143 | 29512449 |
Graft versus host disease in skin | 12.01 | 10.24 | 20 | 45915 | 3359 | 29525233 |
Psoriatic arthropathy | 11.86 | 10.24 | 4 | 45931 | 14687 | 29513905 |
Cardiac arrest | 11.84 | 10.24 | 81 | 45854 | 85510 | 29443082 |
Septic embolus | 11.63 | 10.24 | 11 | 45924 | 1039 | 29527553 |
Bacterial diarrhoea | 11.62 | 10.24 | 4 | 45931 | 49 | 29528543 |
Plantar erythema | 11.54 | 10.24 | 4 | 45931 | 50 | 29528542 |
Cor pulmonale chronic | 11.54 | 10.24 | 4 | 45931 | 50 | 29528542 |
Bone marrow oedema | 11.48 | 10.24 | 8 | 45927 | 489 | 29528103 |
Cholangitis sclerosing | 11.48 | 10.24 | 11 | 45924 | 1056 | 29527536 |
Seminoma | 11.41 | 10.24 | 6 | 45929 | 219 | 29528373 |
Renal impairment | 11.23 | 10.24 | 77 | 45858 | 81256 | 29447336 |
Lung abscess | 11.21 | 10.24 | 16 | 45919 | 2350 | 29526242 |
Increased bronchial secretion | 11.12 | 10.24 | 13 | 45922 | 1568 | 29527024 |
Respiratory syncytial virus bronchiolitis | 11.07 | 10.24 | 7 | 45928 | 363 | 29528229 |
Cerebrovascular accident | 11.03 | 10.24 | 72 | 45863 | 76839 | 29451753 |
White coat hypertension | 11.00 | 10.24 | 4 | 45931 | 58 | 29528534 |
Haemoptysis | 10.87 | 10.24 | 83 | 45852 | 30467 | 29498125 |
Middle insomnia | 10.84 | 10.24 | 26 | 45909 | 5682 | 29522910 |
Upper respiratory fungal infection | 10.83 | 10.24 | 5 | 45930 | 137 | 29528455 |
Primary myelofibrosis | 10.82 | 10.24 | 4 | 45931 | 61 | 29528531 |
Pharyngeal oedema | 10.77 | 10.24 | 26 | 45909 | 5708 | 29522884 |
Kidney infection | 10.76 | 10.24 | 23 | 45912 | 4660 | 29523932 |
Gastrointestinal polyp | 10.74 | 10.24 | 3 | 45932 | 17 | 29528575 |
Anal stenosis | 10.73 | 10.24 | 5 | 45930 | 140 | 29528452 |
Paranasal sinus mucosal hypertrophy | 10.64 | 10.24 | 4 | 45931 | 64 | 29528528 |
Catheter site related reaction | 10.62 | 10.24 | 6 | 45929 | 253 | 29528339 |
Pseudomonas infection | 10.58 | 10.24 | 39 | 45896 | 10813 | 29517779 |
Rectal abscess | 10.58 | 10.24 | 10 | 45925 | 944 | 29527648 |
Middle ear effusion | 10.56 | 10.24 | 8 | 45927 | 557 | 29528035 |
Abscess intestinal | 10.44 | 10.24 | 12 | 45923 | 1422 | 29527170 |
Hepatic function abnormal | 10.44 | 10.24 | 29 | 45906 | 39230 | 29489362 |
Device malfunction | 10.42 | 10.24 | 33 | 45902 | 8474 | 29520118 |
Diabetic ketoacidosis | 10.41 | 10.24 | 6 | 45929 | 16067 | 29512525 |
Chronic kidney disease | 10.36 | 10.24 | 26 | 45909 | 36390 | 29492202 |
Respiratory failure | 10.36 | 10.24 | 210 | 45725 | 96921 | 29431671 |
Leukoplakia oral | 10.31 | 10.24 | 4 | 45931 | 70 | 29528522 |
Wound decomposition | 10.31 | 10.24 | 4 | 45931 | 70 | 29528522 |
Palmar-plantar erythrodysaesthesia syndrome | 10.31 | 10.24 | 5 | 45930 | 14754 | 29513838 |
Poor venous access | 10.30 | 10.24 | 18 | 45917 | 3143 | 29525449 |
Physical examination abnormal | 10.28 | 10.24 | 6 | 45929 | 269 | 29528323 |
Coeliac disease | 10.28 | 10.24 | 8 | 45927 | 580 | 29528012 |
Gastrooesophageal sphincter insufficiency | 10.26 | 10.24 | 4 | 45931 | 71 | 29528521 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 1732.31 | 9.76 | 1347 | 103202 | 93878 | 64300305 |
Wheezing | 773.58 | 9.76 | 795 | 103754 | 79784 | 64314399 |
Dyspnoea | 601.42 | 9.76 | 2524 | 102025 | 716150 | 63678033 |
Cough | 419.44 | 9.76 | 1256 | 103293 | 300892 | 64093291 |
Obstructive airways disorder | 411.94 | 9.76 | 324 | 104225 | 22861 | 64371322 |
Chest discomfort | 319.10 | 9.76 | 629 | 103920 | 115477 | 64278706 |
Completed suicide | 264.50 | 9.76 | 28 | 104521 | 224386 | 64169797 |
Toxicity to various agents | 253.36 | 9.76 | 137 | 104412 | 363376 | 64030807 |
Full blood count abnormal | 228.14 | 9.76 | 261 | 104288 | 29496 | 64364687 |
Colitis ulcerative | 227.55 | 9.76 | 231 | 104318 | 22797 | 64371386 |
Productive cough | 218.67 | 9.76 | 411 | 104138 | 72792 | 64321391 |
Sleep disorder due to a general medical condition | 200.13 | 9.76 | 139 | 104410 | 8095 | 64386088 |
Chronic obstructive pulmonary disease | 184.38 | 9.76 | 376 | 104173 | 70672 | 64323511 |
Nasal polyps | 166.90 | 9.76 | 92 | 104457 | 3537 | 64390646 |
Drug abuse | 154.66 | 9.76 | 17 | 104532 | 132357 | 64261826 |
Eosinophilic granulomatosis with polyangiitis | 140.68 | 9.76 | 76 | 104473 | 2806 | 64391377 |
Frequent bowel movements | 129.35 | 9.76 | 154 | 104395 | 18151 | 64376032 |
Acute kidney injury | 126.93 | 9.76 | 344 | 104205 | 448896 | 63945287 |
Sputum discoloured | 124.16 | 9.76 | 149 | 104400 | 17707 | 64376476 |
Chronic sinusitis | 118.39 | 9.76 | 91 | 104458 | 6201 | 64387982 |
Bronchospasm | 116.22 | 9.76 | 159 | 104390 | 21523 | 64372660 |
Upper-airway cough syndrome | 115.23 | 9.76 | 103 | 104446 | 8667 | 64385516 |
Blood immunoglobulin E increased | 112.90 | 9.76 | 73 | 104476 | 3771 | 64390412 |
Pneumonia | 111.09 | 9.76 | 1389 | 103160 | 558187 | 63835996 |
Contraindicated product administered | 107.30 | 9.76 | 22 | 104527 | 107807 | 64286376 |
Forced expiratory volume decreased | 107.18 | 9.76 | 89 | 104460 | 6778 | 64387405 |
Eosinophil count increased | 106.83 | 9.76 | 123 | 104426 | 13989 | 64380194 |
Bronchiectasis | 106.63 | 9.76 | 123 | 104426 | 14017 | 64380166 |
Respiratory symptom | 104.79 | 9.76 | 64 | 104485 | 2989 | 64391194 |
Blood test abnormal | 103.39 | 9.76 | 116 | 104433 | 12827 | 64381356 |
Gastrooesophageal reflux disease | 102.28 | 9.76 | 332 | 104217 | 82811 | 64311372 |
Febrile neutropenia | 101.19 | 9.76 | 93 | 104456 | 187564 | 64206619 |
Neutropenia | 94.08 | 9.76 | 152 | 104397 | 239472 | 64154711 |
Loss of personal independence in daily activities | 93.37 | 9.76 | 294 | 104255 | 72160 | 64322023 |
Polycystic ovaries | 91.93 | 9.76 | 52 | 104497 | 2103 | 64392080 |
Heart rate increased | 90.57 | 9.76 | 358 | 104191 | 98317 | 64295866 |
Asthmatic crisis | 90.46 | 9.76 | 48 | 104501 | 1708 | 64392475 |
Weight decreased | 89.14 | 9.76 | 778 | 103771 | 284961 | 64109222 |
Growth failure | 89.00 | 9.76 | 27 | 104522 | 203 | 64393980 |
Middle insomnia | 82.32 | 9.76 | 103 | 104446 | 12774 | 64381409 |
Hand deformity | 78.81 | 9.76 | 6 | 104543 | 62765 | 64331418 |
Off label use | 78.18 | 9.76 | 1449 | 103100 | 631357 | 63762826 |
Death | 75.95 | 9.76 | 465 | 104084 | 482240 | 63911943 |
Reversible airways obstruction | 75.80 | 9.76 | 37 | 104512 | 1101 | 64393082 |
Synovitis | 75.47 | 9.76 | 33 | 104516 | 99057 | 64295126 |
Labile blood pressure | 74.99 | 9.76 | 45 | 104504 | 2035 | 64392148 |
Faecal calprotectin increased | 73.69 | 9.76 | 55 | 104494 | 3585 | 64390598 |
Systemic lupus erythematosus | 72.86 | 9.76 | 18 | 104531 | 77594 | 64316589 |
Dust allergy | 72.44 | 9.76 | 35 | 104514 | 1018 | 64393165 |
Dyspnoea exertional | 72.14 | 9.76 | 273 | 104276 | 73457 | 64320726 |
Intentional overdose | 71.66 | 9.76 | 28 | 104521 | 89916 | 64304267 |
Cushingoid | 70.99 | 9.76 | 74 | 104475 | 7529 | 64386654 |
Bronchial secretion retention | 69.36 | 9.76 | 46 | 104503 | 2481 | 64391702 |
Respiratory tract infection | 69.07 | 9.76 | 173 | 104376 | 37234 | 64356949 |
Thrombocytopenia | 68.76 | 9.76 | 164 | 104385 | 223637 | 64170546 |
Therapeutic product effect incomplete | 68.10 | 9.76 | 340 | 104209 | 103142 | 64291041 |
Breath sounds abnormal | 67.77 | 9.76 | 89 | 104460 | 11580 | 64382603 |
Nasal congestion | 66.07 | 9.76 | 230 | 104319 | 59428 | 64334755 |
Sleep apnoea syndrome | 65.96 | 9.76 | 148 | 104401 | 29684 | 64364499 |
Upper respiratory fungal infection | 65.67 | 9.76 | 23 | 104526 | 284 | 64393899 |
Rhinitis allergic | 65.55 | 9.76 | 73 | 104476 | 8005 | 64386178 |
Eosinophilic bronchitis | 64.83 | 9.76 | 24 | 104525 | 351 | 64393832 |
White blood cell count decreased | 62.97 | 9.76 | 99 | 104450 | 157738 | 64236445 |
Platelet count decreased | 62.45 | 9.76 | 110 | 104439 | 167601 | 64226582 |
Sinusitis fungal | 61.74 | 9.76 | 37 | 104512 | 1669 | 64392514 |
Alopecia | 60.50 | 9.76 | 110 | 104439 | 165580 | 64228603 |
Gastrointestinal wall thickening | 59.43 | 9.76 | 39 | 104510 | 2066 | 64392117 |
Adrenal suppression | 59.27 | 9.76 | 33 | 104516 | 1294 | 64392889 |
Sensitisation | 58.68 | 9.76 | 36 | 104513 | 1695 | 64392488 |
Blood pressure increased | 58.59 | 9.76 | 479 | 104070 | 172073 | 64222110 |
Vital capacity decreased | 57.20 | 9.76 | 30 | 104519 | 1042 | 64393141 |
Condition aggravated | 56.84 | 9.76 | 883 | 103666 | 371543 | 64022640 |
Hyper IgE syndrome | 54.99 | 9.76 | 23 | 104526 | 472 | 64393711 |
Fall | 54.87 | 9.76 | 423 | 104126 | 416403 | 63977780 |
Cushing's syndrome | 54.73 | 9.76 | 28 | 104521 | 923 | 64393260 |
Pericarditis | 54.02 | 9.76 | 17 | 104532 | 62499 | 64331684 |
Malignant neoplasm progression | 53.94 | 9.76 | 62 | 104487 | 112809 | 64281374 |
Arthropathy | 52.02 | 9.76 | 72 | 104477 | 120895 | 64273288 |
Hepatic enzyme increased | 50.41 | 9.76 | 83 | 104466 | 129860 | 64264323 |
Anaphylactic reaction | 49.78 | 9.76 | 232 | 104317 | 68432 | 64325751 |
Peak expiratory flow rate decreased | 49.73 | 9.76 | 23 | 104526 | 605 | 64393578 |
Infective pulmonary exacerbation of cystic fibrosis | 49.40 | 9.76 | 77 | 104472 | 11719 | 64382464 |
Anosmia | 48.61 | 9.76 | 47 | 104502 | 4370 | 64389813 |
Spirometry abnormal | 48.45 | 9.76 | 22 | 104527 | 554 | 64393629 |
Rheumatoid arthritis | 48.40 | 9.76 | 123 | 104426 | 164171 | 64230012 |
Stomatitis | 48.38 | 9.76 | 64 | 104485 | 109541 | 64284642 |
Sputum increased | 48.37 | 9.76 | 43 | 104506 | 3592 | 64390591 |
Salpingo-oophorectomy unilateral | 48.32 | 9.76 | 21 | 104528 | 475 | 64393708 |
Graft versus host disease | 48.16 | 9.76 | 83 | 104466 | 13730 | 64380453 |
Joint swelling | 48.05 | 9.76 | 183 | 104366 | 215199 | 64178984 |
Mucosal inflammation | 47.40 | 9.76 | 21 | 104528 | 62563 | 64331620 |
Pancytopenia | 47.26 | 9.76 | 101 | 104448 | 143208 | 64250975 |
Emphysema | 47.05 | 9.76 | 83 | 104466 | 13986 | 64380197 |
Intestinal stenosis | 46.75 | 9.76 | 40 | 104509 | 3174 | 64391009 |
Impaired quality of life | 46.63 | 9.76 | 55 | 104494 | 6416 | 64387767 |
Butterfly rash | 46.35 | 9.76 | 27 | 104522 | 1155 | 64393028 |
Lung diffusion test abnormal | 46.03 | 9.76 | 15 | 104534 | 146 | 64394037 |
Hypotension | 45.82 | 9.76 | 396 | 104153 | 380578 | 64013605 |
Ileal stenosis | 45.51 | 9.76 | 33 | 104516 | 2057 | 64392126 |
Aspergillus infection | 45.23 | 9.76 | 89 | 104460 | 16290 | 64377893 |
Mycotic allergy | 45.07 | 9.76 | 25 | 104524 | 973 | 64393210 |
Cystic fibrosis | 44.46 | 9.76 | 40 | 104509 | 3394 | 64390789 |
Graft versus host disease in gastrointestinal tract | 44.31 | 9.76 | 50 | 104499 | 5562 | 64388621 |
Treatment failure | 44.04 | 9.76 | 76 | 104473 | 116740 | 64277443 |
Overdose | 43.57 | 9.76 | 124 | 104425 | 159442 | 64234741 |
Neutrophil count decreased | 43.09 | 9.76 | 37 | 104512 | 77159 | 64317024 |
Female genital tract fistula | 42.63 | 9.76 | 35 | 104514 | 2623 | 64391560 |
Systemic mycosis | 42.40 | 9.76 | 33 | 104516 | 2290 | 64391893 |
Dysphonia | 42.30 | 9.76 | 168 | 104381 | 46214 | 64347969 |
Coma | 41.99 | 9.76 | 48 | 104501 | 87567 | 64306616 |
Ejection fraction | 41.70 | 9.76 | 26 | 104523 | 1260 | 64392923 |
Duodenal ulcer perforation | 41.57 | 9.76 | 4 | 104545 | 34621 | 64359562 |
Ventricular failure | 41.28 | 9.76 | 19 | 104530 | 494 | 64393689 |
Glossodynia | 41.26 | 9.76 | 27 | 104522 | 64669 | 64329514 |
Multiple allergies | 41.21 | 9.76 | 49 | 104500 | 5765 | 64388418 |
Respiration abnormal | 41.14 | 9.76 | 51 | 104498 | 6264 | 64387919 |
Dyspnoea at rest | 41.05 | 9.76 | 51 | 104498 | 6278 | 64387905 |
Therapeutic reaction time decreased | 40.92 | 9.76 | 30 | 104519 | 1902 | 64392281 |
Eosinophilia | 40.60 | 9.76 | 145 | 104404 | 37931 | 64356252 |
Rhonchi | 40.29 | 9.76 | 38 | 104511 | 3425 | 64390758 |
Mucous stools | 40.17 | 9.76 | 37 | 104512 | 3236 | 64390947 |
Helicobacter infection | 39.91 | 9.76 | 7 | 104542 | 38355 | 64355828 |
Sinusitis | 39.68 | 9.76 | 386 | 104163 | 145542 | 64248641 |
Asphyxia | 39.44 | 9.76 | 62 | 104487 | 9504 | 64384679 |
Confusional state | 39.20 | 9.76 | 255 | 104294 | 260889 | 64133294 |
Intestinal obstruction | 38.54 | 9.76 | 138 | 104411 | 36148 | 64358035 |
Bronchopulmonary aspergillosis allergic | 38.52 | 9.76 | 27 | 104522 | 1595 | 64392588 |
Cyanosis | 38.34 | 9.76 | 100 | 104449 | 22055 | 64372128 |
Pain | 38.32 | 9.76 | 649 | 103900 | 552862 | 63841321 |
Disease progression | 38.02 | 9.76 | 111 | 104438 | 141569 | 64252614 |
Swelling | 37.78 | 9.76 | 133 | 104416 | 160085 | 64234098 |
Intestinal fistula | 37.73 | 9.76 | 24 | 104525 | 1205 | 64392978 |
Impaired healing | 37.54 | 9.76 | 26 | 104523 | 60447 | 64333736 |
Lung disorder | 36.83 | 9.76 | 195 | 104354 | 60505 | 64333678 |
Respiratory distress | 36.60 | 9.76 | 175 | 104374 | 52156 | 64342027 |
Hepatic ischaemia | 36.56 | 9.76 | 22 | 104527 | 1000 | 64393183 |
Adrenal insufficiency | 36.39 | 9.76 | 99 | 104450 | 22388 | 64371795 |
Somnolence | 36.36 | 9.76 | 188 | 104361 | 203457 | 64190726 |
Cardio-respiratory arrest | 36.19 | 9.76 | 65 | 104484 | 98328 | 64295855 |
Embolism venous | 36.14 | 9.76 | 36 | 104513 | 3471 | 64390712 |
Colitis | 35.94 | 9.76 | 189 | 104360 | 58485 | 64335698 |
Drug intolerance | 35.60 | 9.76 | 170 | 104379 | 187822 | 64206361 |
Anaemia | 35.02 | 9.76 | 419 | 104130 | 378261 | 64015922 |
Bronchomalacia | 33.99 | 9.76 | 13 | 104536 | 209 | 64393974 |
Eosinophilic oesophagitis | 33.67 | 9.76 | 16 | 104533 | 448 | 64393735 |
Oropharyngeal pain | 33.61 | 9.76 | 253 | 104296 | 88614 | 64305569 |
Drug level below therapeutic | 33.46 | 9.76 | 50 | 104499 | 7334 | 64386849 |
Rhinorrhoea | 33.25 | 9.76 | 188 | 104361 | 59781 | 64334402 |
Intentional self-injury | 33.23 | 9.76 | 4 | 104545 | 29040 | 64365143 |
Muscle relaxant therapy | 33.16 | 9.76 | 12 | 104537 | 164 | 64394019 |
Rheumatoid factor positive | 32.99 | 9.76 | 8 | 104541 | 34930 | 64359253 |
Sinus operation | 32.95 | 9.76 | 25 | 104524 | 1670 | 64392513 |
Polyp | 32.87 | 9.76 | 47 | 104502 | 6626 | 64387557 |
Bronchitis | 32.74 | 9.76 | 294 | 104255 | 108449 | 64285734 |
Throat irritation | 32.71 | 9.76 | 122 | 104427 | 32589 | 64361594 |
Mite allergy | 32.34 | 9.76 | 18 | 104531 | 705 | 64393478 |
Herpes simplex oesophagitis | 31.90 | 9.76 | 13 | 104536 | 249 | 64393934 |
Suicide attempt | 31.80 | 9.76 | 41 | 104508 | 70966 | 64323217 |
Sopor | 31.77 | 9.76 | 5 | 104544 | 29656 | 64364527 |
Nausea | 31.66 | 9.76 | 1002 | 103547 | 784798 | 63609385 |
Eczema | 31.53 | 9.76 | 113 | 104436 | 29607 | 64364576 |
Upper respiratory tract infection | 31.45 | 9.76 | 214 | 104335 | 72571 | 64321612 |
Conjunctivitis allergic | 31.33 | 9.76 | 20 | 104529 | 1010 | 64393173 |
Pulmonary function test decreased | 31.08 | 9.76 | 45 | 104504 | 6416 | 64387767 |
Obstruction | 31.02 | 9.76 | 32 | 104517 | 3216 | 64390967 |
Ascites | 30.77 | 9.76 | 33 | 104516 | 61968 | 64332215 |
Increased upper airway secretion | 30.57 | 9.76 | 33 | 104516 | 3494 | 64390689 |
Total lung capacity decreased | 30.43 | 9.76 | 24 | 104525 | 1698 | 64392485 |
Colitis microscopic | 30.41 | 9.76 | 48 | 104501 | 7384 | 64386799 |
Drug specific antibody | 30.32 | 9.76 | 26 | 104523 | 2069 | 64392114 |
Hypothyroidism | 30.28 | 9.76 | 138 | 104411 | 40319 | 64353864 |
Nephrectomy | 29.94 | 9.76 | 22 | 104527 | 1400 | 64392783 |
Restrictive pulmonary disease | 29.51 | 9.76 | 26 | 104523 | 2146 | 64392037 |
Apoptosis | 29.32 | 9.76 | 13 | 104536 | 309 | 64393874 |
Blister | 29.32 | 9.76 | 54 | 104495 | 80913 | 64313270 |
Sputum culture positive | 29.24 | 9.76 | 30 | 104519 | 2996 | 64391187 |
Sepsis | 29.20 | 9.76 | 236 | 104313 | 230105 | 64164078 |
Neoplasm progression | 29.10 | 9.76 | 15 | 104534 | 40949 | 64353234 |
Sinus disorder | 28.93 | 9.76 | 76 | 104473 | 16832 | 64377351 |
Respiratory tract inflammation | 28.24 | 9.76 | 17 | 104532 | 773 | 64393410 |
Bronchiolitis | 28 | 9.76 | 32 | 104517 | 3609 | 64390574 |
Abdominal pain | 27.90 | 9.76 | 683 | 103866 | 311692 | 64082491 |
Psoriatic arthropathy | 27.68 | 9.76 | 18 | 104531 | 43263 | 64350920 |
Respiratory disorder | 27.64 | 9.76 | 124 | 104425 | 35987 | 64358196 |
Pouchitis | 27.58 | 9.76 | 17 | 104532 | 807 | 64393376 |
Hiatus hernia | 27.57 | 9.76 | 83 | 104466 | 19874 | 64374309 |
Status asthmaticus | 27.49 | 9.76 | 18 | 104531 | 950 | 64393233 |
Leukopenia | 27.39 | 9.76 | 79 | 104470 | 101163 | 64293020 |
Pseudomonas infection | 27.22 | 9.76 | 77 | 104472 | 17806 | 64376377 |
Frustration tolerance decreased | 27.08 | 9.76 | 41 | 104508 | 6084 | 64388099 |
Renal impairment | 26.79 | 9.76 | 120 | 104429 | 134897 | 64259286 |
Circumstance or information capable of leading to medication error | 26.78 | 9.76 | 30 | 104519 | 3310 | 64390873 |
Haemoptysis | 26.69 | 9.76 | 153 | 104396 | 48895 | 64345288 |
Rales | 26.62 | 9.76 | 69 | 104480 | 15160 | 64379023 |
Allergy to animal | 26.62 | 9.76 | 18 | 104531 | 1003 | 64393180 |
Throat clearing | 26.60 | 9.76 | 20 | 104529 | 1318 | 64392865 |
Hyponatraemia | 26.43 | 9.76 | 137 | 104412 | 148202 | 64245981 |
Neurotoxicity | 26.42 | 9.76 | 6 | 104543 | 27398 | 64366785 |
Osteoporosis | 26.08 | 9.76 | 136 | 104413 | 41944 | 64352239 |
Growth retardation | 25.97 | 9.76 | 21 | 104528 | 1540 | 64392643 |
Weight gain poor | 25.95 | 9.76 | 16 | 104533 | 760 | 64393423 |
Vocal cord dysfunction | 25.88 | 9.76 | 13 | 104536 | 412 | 64393771 |
Inappropriate schedule of product administration | 25.51 | 9.76 | 245 | 104304 | 92041 | 64302142 |
Sedation | 25.51 | 9.76 | 18 | 104531 | 41444 | 64352739 |
Intentional device misuse | 25.43 | 9.76 | 15 | 104534 | 657 | 64393526 |
Laryngeal stenosis | 25.37 | 9.76 | 16 | 104533 | 791 | 64393392 |
Pulmonary mass | 25.21 | 9.76 | 91 | 104458 | 23925 | 64370258 |
Herpes zoster meningoencephalitis | 25.06 | 9.76 | 15 | 104534 | 675 | 64393508 |
Respiratory tract congestion | 25.00 | 9.76 | 70 | 104479 | 16095 | 64378088 |
Decreased appetite | 24.93 | 9.76 | 314 | 104235 | 280975 | 64113208 |
Night sweats | 24.81 | 9.76 | 120 | 104429 | 35926 | 64358257 |
Bacterial disease carrier | 24.59 | 9.76 | 17 | 104532 | 982 | 64393201 |
Rhinitis | 24.46 | 9.76 | 54 | 104495 | 10711 | 64383472 |
Lower respiratory tract infection | 24.12 | 9.76 | 247 | 104302 | 94367 | 64299816 |
Product quality issue | 24.08 | 9.76 | 104 | 104445 | 29695 | 64364488 |
Lung diffusion test decreased | 24.05 | 9.76 | 18 | 104531 | 1178 | 64393005 |
Oropharyngeal discomfort | 24.00 | 9.76 | 36 | 104513 | 5299 | 64388884 |
Palpitations | 23.94 | 9.76 | 267 | 104282 | 104221 | 64289962 |
Multiple sclerosis relapse | 23.84 | 9.76 | 19 | 104530 | 41116 | 64353067 |
Increased bronchial secretion | 23.60 | 9.76 | 26 | 104523 | 2816 | 64391367 |
Delayed puberty | 23.52 | 9.76 | 9 | 104540 | 145 | 64394038 |
Wound | 23.49 | 9.76 | 56 | 104493 | 76421 | 64317762 |
Abdominal discomfort | 23.47 | 9.76 | 186 | 104363 | 182136 | 64212047 |
Encephalopathy | 23.34 | 9.76 | 37 | 104512 | 58782 | 64335401 |
Mycobacterium test positive | 23.28 | 9.76 | 12 | 104537 | 402 | 64393781 |
Venous pressure jugular increased | 23.18 | 9.76 | 18 | 104531 | 1245 | 64392938 |
Proctitis | 23.01 | 9.76 | 27 | 104522 | 3132 | 64391051 |
Folliculitis | 22.92 | 9.76 | 10 | 104539 | 30067 | 64364116 |
Product use in unapproved indication | 22.55 | 9.76 | 407 | 104142 | 176211 | 64217972 |
Graft versus host disease in skin | 22.52 | 9.76 | 35 | 104514 | 5312 | 64388871 |
Tachypnoea | 22.45 | 9.76 | 94 | 104455 | 26477 | 64367706 |
Electrocardiogram QT prolonged | 22.22 | 9.76 | 61 | 104488 | 79387 | 64314796 |
Eye swelling | 22.19 | 9.76 | 83 | 104466 | 22198 | 64371985 |
Periumbilical abscess | 22.17 | 9.76 | 7 | 104542 | 61 | 64394122 |
Nasal obstruction | 22.02 | 9.76 | 18 | 104531 | 1341 | 64392842 |
Intestinal resection | 21.98 | 9.76 | 26 | 104523 | 3042 | 64391141 |
Procedural pneumothorax | 21.87 | 9.76 | 7 | 104542 | 64 | 64394119 |
Botulism | 21.86 | 9.76 | 11 | 104538 | 350 | 64393833 |
Haematochezia | 21.82 | 9.76 | 183 | 104366 | 66190 | 64327993 |
Secretion discharge | 21.73 | 9.76 | 55 | 104494 | 11909 | 64382274 |
Sensitivity to weather change | 21.67 | 9.76 | 39 | 104510 | 6675 | 64387508 |
Body temperature decreased | 21.34 | 9.76 | 91 | 104458 | 25837 | 64368346 |
Lactic acidosis | 21.32 | 9.76 | 42 | 104507 | 61368 | 64332815 |
Plasma cell myeloma | 21.26 | 9.76 | 26 | 104523 | 46049 | 64348134 |
Throat tightness | 21.20 | 9.76 | 84 | 104465 | 23076 | 64371107 |
Blood creatinine increased | 21.16 | 9.76 | 131 | 104418 | 135651 | 64258532 |
Bradycardia | 21.16 | 9.76 | 109 | 104440 | 118110 | 64276073 |
Defaecation urgency | 20.99 | 9.76 | 29 | 104520 | 3960 | 64390223 |
Therapeutic response shortened | 20.87 | 9.76 | 49 | 104500 | 10121 | 64384062 |
Hypoventilation | 20.82 | 9.76 | 36 | 104513 | 5970 | 64388213 |
Endometriosis | 20.57 | 9.76 | 24 | 104525 | 2768 | 64391415 |
Drug hypersensitivity | 20.50 | 9.76 | 267 | 104282 | 237548 | 64156635 |
Rhabdomyolysis | 20.39 | 9.76 | 78 | 104471 | 91648 | 64302535 |
Pulmonary artery stenosis congenital | 20.23 | 9.76 | 5 | 104544 | 15 | 64394168 |
Product use issue | 20.21 | 9.76 | 352 | 104197 | 151363 | 64242820 |
Delirium | 20.21 | 9.76 | 52 | 104497 | 69142 | 64325041 |
Bronchial obstruction | 20.21 | 9.76 | 22 | 104527 | 2352 | 64391831 |
Sinus congestion | 20.20 | 9.76 | 63 | 104486 | 15376 | 64378807 |
Infusion related reaction | 20.15 | 9.76 | 170 | 104379 | 164297 | 64229886 |
Aspirin-exacerbated respiratory disease | 20.14 | 9.76 | 16 | 104533 | 1144 | 64393039 |
Laryngeal oedema | 20.06 | 9.76 | 39 | 104510 | 7074 | 64387109 |
Cytomegalovirus colitis | 19.84 | 9.76 | 28 | 104521 | 3900 | 64390283 |
Viral infection | 19.83 | 9.76 | 113 | 104436 | 36027 | 64358156 |
Infective exacerbation of chronic obstructive airways disease | 19.72 | 9.76 | 22 | 104527 | 2416 | 64391767 |
Eye infection fungal | 19.55 | 9.76 | 11 | 104538 | 440 | 64393743 |
Nasopharyngitis | 19.41 | 9.76 | 435 | 104114 | 195638 | 64198545 |
Tumour lysis syndrome | 19.26 | 9.76 | 4 | 104545 | 19436 | 64374747 |
Cytokine release syndrome | 19.22 | 9.76 | 5 | 104544 | 20824 | 64373359 |
Musculoskeletal stiffness | 19.13 | 9.76 | 119 | 104430 | 123087 | 64271096 |
Pharyngeal oedema | 19.06 | 9.76 | 62 | 104487 | 15469 | 64378714 |
Vomiting | 19.05 | 9.76 | 716 | 103833 | 550401 | 63843782 |
Periorbital oedema | 18.93 | 9.76 | 39 | 104510 | 7375 | 64386808 |
Respiratory rate increased | 18.85 | 9.76 | 69 | 104480 | 18262 | 64375921 |
Poisoning | 18.81 | 9.76 | 6 | 104543 | 21873 | 64372310 |
Metabolic acidosis | 18.73 | 9.76 | 56 | 104493 | 70902 | 64323281 |
Haemoglobin decreased | 18.70 | 9.76 | 214 | 104335 | 194849 | 64199334 |
Peripheral swelling | 18.70 | 9.76 | 233 | 104316 | 208920 | 64185263 |
Smoke sensitivity | 18.69 | 9.76 | 11 | 104538 | 480 | 64393703 |
Abscess intestinal | 18.59 | 9.76 | 21 | 104528 | 2339 | 64391844 |
Otorrhoea | 18.52 | 9.76 | 17 | 104532 | 1480 | 64392703 |
Activated partial thromboplastin time shortened | 18.49 | 9.76 | 13 | 104536 | 772 | 64393411 |
Drug level above therapeutic | 18.45 | 9.76 | 37 | 104512 | 6864 | 64387319 |
Kyphosis | 18.35 | 9.76 | 21 | 104528 | 2372 | 64391811 |
Rectal prolapse | 18.31 | 9.76 | 18 | 104531 | 1708 | 64392475 |
Osteomyelitis | 18.30 | 9.76 | 11 | 104538 | 27576 | 64366607 |
Myelodysplastic syndrome | 18.29 | 9.76 | 11 | 104538 | 27568 | 64366615 |
Hepatic function abnormal | 18.27 | 9.76 | 49 | 104500 | 64264 | 64329919 |
Hip arthroplasty | 18.10 | 9.76 | 6 | 104543 | 21345 | 64372838 |
Nasal discharge discolouration | 18.06 | 9.76 | 18 | 104531 | 1736 | 64392447 |
Atypical mycobacterium test positive | 18.05 | 9.76 | 4 | 104545 | 6 | 64394177 |
Drug specific antibody present | 18.00 | 9.76 | 31 | 104518 | 5123 | 64389060 |
Hypothalamic pituitary adrenal axis suppression | 17.92 | 9.76 | 9 | 104540 | 285 | 64393898 |
Hepatorenal syndrome | 17.89 | 9.76 | 26 | 104523 | 3720 | 64390463 |
Ligament pain | 17.86 | 9.76 | 8 | 104541 | 195 | 64393988 |
Swollen tongue | 17.70 | 9.76 | 107 | 104442 | 34847 | 64359336 |
Cardiac arrest | 17.66 | 9.76 | 162 | 104387 | 153902 | 64240281 |
Accidental overdose | 17.63 | 9.76 | 17 | 104532 | 33540 | 64360643 |
Steroid dependence | 17.57 | 9.76 | 10 | 104539 | 409 | 64393774 |
Catarrh | 17.53 | 9.76 | 11 | 104538 | 539 | 64393644 |
Infusion site extravasation | 17.50 | 9.76 | 36 | 104513 | 6801 | 64387382 |
Tracheostomy infection | 17.29 | 9.76 | 6 | 104543 | 72 | 64394111 |
Abdominal abscess | 17.10 | 9.76 | 34 | 104515 | 6270 | 64387913 |
Dysarthria | 17.07 | 9.76 | 45 | 104504 | 59361 | 64334822 |
Dermatitis contact | 17.00 | 9.76 | 42 | 104507 | 8958 | 64385225 |
Drug level decreased | 16.99 | 9.76 | 49 | 104500 | 11454 | 64382729 |
Cortisol decreased | 16.88 | 9.76 | 17 | 104532 | 1660 | 64392523 |
Bronchitis bacterial | 16.88 | 9.76 | 15 | 104534 | 1252 | 64392931 |
Oedema mouth | 16.82 | 9.76 | 22 | 104527 | 2851 | 64391332 |
Penile erythema | 16.81 | 9.76 | 7 | 104542 | 142 | 64394041 |
Sleep disorder due to general medical condition, insomnia type | 16.70 | 9.76 | 11 | 104538 | 26259 | 64367924 |
Tracheitis | 16.65 | 9.76 | 15 | 104534 | 1275 | 64392908 |
Cerebrovascular accident | 16.50 | 9.76 | 143 | 104406 | 137440 | 64256743 |
Bone marrow failure | 16.47 | 9.76 | 33 | 104516 | 47919 | 64346264 |
Candida infection | 16.44 | 9.76 | 97 | 104452 | 31322 | 64362861 |
Large intestinal stenosis | 16.39 | 9.76 | 20 | 104529 | 2417 | 64391766 |
White coat hypertension | 16.26 | 9.76 | 10 | 104539 | 473 | 64393710 |
Bacterial toxaemia | 16.20 | 9.76 | 7 | 104542 | 156 | 64394027 |
Device expulsion | 16.15 | 9.76 | 7 | 104542 | 21129 | 64373054 |
Malaise | 16.13 | 9.76 | 791 | 103758 | 395456 | 63998727 |
Fungal oesophagitis | 16.01 | 9.76 | 12 | 104537 | 787 | 64393396 |
Blood pressure fluctuation | 15.99 | 9.76 | 141 | 104408 | 51730 | 64342453 |
Mitochondrial neurogastrointestinal encephalopathy | 15.94 | 9.76 | 4 | 104545 | 13 | 64394170 |
Swelling face | 15.82 | 9.76 | 156 | 104393 | 59010 | 64335173 |
Aphonia | 15.82 | 9.76 | 40 | 104509 | 8657 | 64385526 |
Varicella zoster virus infection | 15.75 | 9.76 | 25 | 104524 | 3863 | 64390320 |
Hysterectomy | 15.73 | 9.76 | 29 | 104520 | 5056 | 64389127 |
Perfume sensitivity | 15.72 | 9.76 | 11 | 104538 | 648 | 64393535 |
Obstructive pancreatitis | 15.66 | 9.76 | 11 | 104538 | 652 | 64393531 |
Nasal oedema | 15.60 | 9.76 | 13 | 104536 | 995 | 64393188 |
Adrenocortical insufficiency acute | 15.57 | 9.76 | 20 | 104529 | 2545 | 64391638 |
Neuropathy peripheral | 15.53 | 9.76 | 119 | 104430 | 117406 | 64276777 |
Adrenal cortex necrosis | 15.50 | 9.76 | 4 | 104545 | 15 | 64394168 |
Aphthous ulcer | 15.37 | 9.76 | 51 | 104498 | 12855 | 64381328 |
Stridor | 15.33 | 9.76 | 28 | 104521 | 4846 | 64389337 |
Sputum purulent | 15.32 | 9.76 | 14 | 104535 | 1212 | 64392971 |
Cardiogenic shock | 15.28 | 9.76 | 18 | 104531 | 32409 | 64361774 |
Type 2 diabetes mellitus | 15.28 | 9.76 | 101 | 104448 | 33919 | 64360264 |
Sleep disorder | 15.27 | 9.76 | 156 | 104393 | 59553 | 64334630 |
Nasal disorder | 15.23 | 9.76 | 21 | 104528 | 2863 | 64391320 |
Rash | 14.89 | 9.76 | 600 | 103949 | 457949 | 63936234 |
Liver disorder | 14.89 | 9.76 | 41 | 104508 | 53310 | 64340873 |
Mobility decreased | 14.88 | 9.76 | 80 | 104469 | 85760 | 64308423 |
Retinal ischaemia | 14.85 | 9.76 | 11 | 104538 | 709 | 64393474 |
Pharyngeal hypoaesthesia | 14.77 | 9.76 | 8 | 104541 | 297 | 64393886 |
Hyperplastic cholecystopathy | 14.63 | 9.76 | 6 | 104543 | 117 | 64394066 |
Respiratory arrest | 14.58 | 9.76 | 41 | 104508 | 52944 | 64341239 |
Feeling jittery | 14.47 | 9.76 | 44 | 104505 | 10591 | 64383592 |
Bowel movement irregularity | 14.40 | 9.76 | 27 | 104522 | 4766 | 64389417 |
Superinfection | 14.40 | 9.76 | 24 | 104525 | 3862 | 64390321 |
Gastroenteritis norovirus | 14.34 | 9.76 | 20 | 104529 | 2755 | 64391428 |
Myocardial infarction | 14.34 | 9.76 | 186 | 104363 | 165635 | 64228548 |
Lip infection | 14.26 | 9.76 | 6 | 104543 | 125 | 64394058 |
Incorrect dose administered | 14.25 | 9.76 | 156 | 104393 | 60609 | 64333574 |
Laryngeal cryptococcosis | 14.21 | 9.76 | 3 | 104546 | 3 | 64394180 |
Inflammatory bowel disease | 14.19 | 9.76 | 26 | 104523 | 4512 | 64389671 |
Oligoarthritis | 14.13 | 9.76 | 8 | 104541 | 324 | 64393859 |
Extrapyramidal disorder | 14.12 | 9.76 | 7 | 104542 | 19545 | 64374638 |
Rotavirus infection | 14.08 | 9.76 | 10 | 104539 | 603 | 64393580 |
Blood bilirubin increased | 14.08 | 9.76 | 47 | 104502 | 57506 | 64336677 |
Depressed level of consciousness | 14.06 | 9.76 | 76 | 104473 | 81360 | 64312823 |
Tooth discolouration | 14.02 | 9.76 | 12 | 104537 | 953 | 64393230 |
Proctalgia | 13.99 | 9.76 | 35 | 104514 | 7524 | 64386659 |
Type IV hypersensitivity reaction | 13.86 | 9.76 | 22 | 104527 | 3400 | 64390783 |
Abscess | 13.82 | 9.76 | 65 | 104484 | 19239 | 64374944 |
Norovirus infection | 13.73 | 9.76 | 7 | 104542 | 229 | 64393954 |
Aspartate aminotransferase increased | 13.70 | 9.76 | 126 | 104423 | 119662 | 64274521 |
Cryptosporidiosis infection | 13.60 | 9.76 | 10 | 104539 | 637 | 64393546 |
Mental status changes | 13.60 | 9.76 | 52 | 104497 | 61110 | 64333073 |
Blood cholesterol increased | 13.58 | 9.76 | 39 | 104510 | 50027 | 64344156 |
Bulimia nervosa | 13.56 | 9.76 | 7 | 104542 | 235 | 64393948 |
Influenza | 13.41 | 9.76 | 245 | 104304 | 106286 | 64287897 |
Bronchial wall thickening | 13.40 | 9.76 | 16 | 104533 | 1891 | 64392292 |
Hypersensitivity pneumonitis | 13.40 | 9.76 | 21 | 104528 | 3211 | 64390972 |
Oxygen saturation decreased | 13.32 | 9.76 | 246 | 104303 | 106930 | 64287253 |
Small intestinal stenosis | 13.27 | 9.76 | 10 | 104539 | 661 | 64393522 |
Tremor | 13.17 | 9.76 | 324 | 104225 | 147906 | 64246277 |
Red blood cell sedimentation rate abnormal | 13.11 | 9.76 | 5 | 104544 | 16301 | 64377882 |
Rhinovirus infection | 13.00 | 9.76 | 30 | 104519 | 6126 | 64388057 |
Astrovirus test positive | 12.99 | 9.76 | 3 | 104546 | 6 | 64394177 |
Atopy | 12.99 | 9.76 | 7 | 104542 | 257 | 64393926 |
Orthostatic hypotension | 12.98 | 9.76 | 36 | 104513 | 46702 | 64347481 |
Sneezing | 12.92 | 9.76 | 54 | 104495 | 15197 | 64378986 |
Hypercapnic coma | 12.90 | 9.76 | 8 | 104541 | 384 | 64393799 |
Infrapatellar fat pad inflammation | 12.86 | 9.76 | 6 | 104543 | 161 | 64394022 |
Posterior reversible encephalopathy syndrome | 12.80 | 9.76 | 11 | 104538 | 22935 | 64371248 |
Drug reaction with eosinophilia and systemic symptoms | 12.77 | 9.76 | 45 | 104504 | 54172 | 64340011 |
Pneumonia pseudomonal | 12.77 | 9.76 | 26 | 104523 | 4877 | 64389306 |
Oesophageal candidiasis | 12.68 | 9.76 | 35 | 104514 | 7982 | 64386201 |
Cardiac failure congestive | 12.61 | 9.76 | 143 | 104406 | 130437 | 64263746 |
Miosis | 12.60 | 9.76 | 3 | 104546 | 13263 | 64380920 |
Psychotic disorder | 12.57 | 9.76 | 23 | 104526 | 34555 | 64359628 |
Blood pressure systolic increased | 12.55 | 9.76 | 129 | 104420 | 49324 | 64344859 |
Gastrointestinal anastomotic leak | 12.53 | 9.76 | 8 | 104541 | 404 | 64393779 |
Rectal abscess | 12.51 | 9.76 | 14 | 104535 | 1543 | 64392640 |
Hepatotoxicity | 12.48 | 9.76 | 29 | 104520 | 39933 | 64354250 |
Bronchopulmonary dysplasia | 12.47 | 9.76 | 6 | 104543 | 173 | 64394010 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 12.43 | 9.76 | 12 | 104537 | 1113 | 64393070 |
Nocturnal dyspnoea | 12.42 | 9.76 | 13 | 104536 | 1329 | 64392854 |
Vocal cord disorder | 12.41 | 9.76 | 13 | 104536 | 1330 | 64392853 |
Acquired diaphragmatic eventration | 12.37 | 9.76 | 9 | 104540 | 564 | 64393619 |
Hypoglycaemia | 12.36 | 9.76 | 90 | 104459 | 89802 | 64304381 |
Aural polyp | 12.21 | 9.76 | 5 | 104544 | 97 | 64394086 |
Injury | 12.19 | 9.76 | 48 | 104501 | 55944 | 64338239 |
Lung opacity | 12.18 | 9.76 | 20 | 104529 | 3179 | 64391004 |
Alternaria infection | 12.16 | 9.76 | 9 | 104540 | 579 | 64393604 |
Poor venous access | 12.15 | 9.76 | 46 | 104503 | 12371 | 64381812 |
Acute myeloid leukaemia | 12.15 | 9.76 | 16 | 104533 | 27447 | 64366736 |
Congenital hydronephrosis | 12.14 | 9.76 | 3 | 104546 | 9 | 64394174 |
Ear infection | 12.08 | 9.76 | 72 | 104477 | 23332 | 64370851 |
Acute myocardial infarction | 12.07 | 9.76 | 65 | 104484 | 69653 | 64324530 |
Post viral fatigue syndrome | 12.07 | 9.76 | 7 | 104542 | 297 | 64393886 |
Terminal insomnia | 12.03 | 9.76 | 11 | 104538 | 953 | 64393230 |
Gastrointestinal polyp | 12.00 | 9.76 | 4 | 104545 | 42 | 64394141 |
Product substitution error | 12.00 | 9.76 | 4 | 104545 | 42 | 64394141 |
Seminoma | 11.98 | 9.76 | 6 | 104543 | 189 | 64393994 |
Weight fluctuation | 11.97 | 9.76 | 35 | 104514 | 8247 | 64385936 |
Infusion site swelling | 11.95 | 9.76 | 27 | 104522 | 5438 | 64388745 |
Seasonal allergy | 11.94 | 9.76 | 44 | 104505 | 11682 | 64382501 |
Urinary tract infection | 11.92 | 9.76 | 285 | 104264 | 231311 | 64162872 |
Exposure to allergen | 11.92 | 9.76 | 6 | 104543 | 191 | 64393992 |
Tracheal haemorrhage | 11.92 | 9.76 | 9 | 104540 | 597 | 64393586 |
Stoma site abscess | 11.86 | 9.76 | 6 | 104543 | 193 | 64393990 |
Oropharyngeal swelling | 11.86 | 9.76 | 12 | 104537 | 1179 | 64393004 |
Hyperadrenocorticism | 11.82 | 9.76 | 7 | 104542 | 309 | 64393874 |
Respiratory syncytial virus infection | 11.76 | 9.76 | 32 | 104517 | 7236 | 64386947 |
Skin striae | 11.73 | 9.76 | 13 | 104536 | 1417 | 64392766 |
Urticaria | 11.63 | 9.76 | 317 | 104232 | 147000 | 64247183 |
Metastases to liver | 11.59 | 9.76 | 13 | 104536 | 23928 | 64370255 |
Septic shock | 11.59 | 9.76 | 112 | 104437 | 105325 | 64288858 |
Respiratory syncytial virus bronchiolitis | 11.59 | 9.76 | 8 | 104541 | 461 | 64393722 |
Complex regional pain syndrome | 11.54 | 9.76 | 14 | 104535 | 1682 | 64392501 |
Skin dystrophy | 11.52 | 9.76 | 4 | 104545 | 48 | 64394135 |
Cognitive disorder | 11.51 | 9.76 | 48 | 104501 | 55039 | 64339144 |
Distal intestinal obstruction syndrome | 11.51 | 9.76 | 9 | 104540 | 629 | 64393554 |
Pertussis | 11.50 | 9.76 | 10 | 104539 | 811 | 64393372 |
Complicated appendicitis | 11.45 | 9.76 | 4 | 104545 | 49 | 64394134 |
Cross sensitivity reaction | 11.43 | 9.76 | 20 | 104529 | 3347 | 64390836 |
Sprue-like enteropathy | 11.42 | 9.76 | 11 | 104538 | 1018 | 64393165 |
Collateral circulation | 11.38 | 9.76 | 4 | 104545 | 50 | 64394133 |
Axillary pain | 11.30 | 9.76 | 14 | 104535 | 1718 | 64392465 |
Pleural effusion | 11.30 | 9.76 | 141 | 104408 | 126418 | 64267765 |
Hyperkalaemia | 11.30 | 9.76 | 107 | 104442 | 101022 | 64293161 |
Legionella test positive | 11.28 | 9.76 | 3 | 104546 | 13 | 64394170 |
Alanine aminotransferase increased | 11.28 | 9.76 | 158 | 104391 | 138873 | 64255310 |
Drug withdrawal syndrome | 11.21 | 9.76 | 21 | 104528 | 31270 | 64362913 |
Oropharyngeal candidiasis | 11.12 | 9.76 | 13 | 104536 | 1502 | 64392681 |
Necrotising retinitis | 11.12 | 9.76 | 11 | 104538 | 1052 | 64393131 |
Tongue blistering | 11.04 | 9.76 | 12 | 104537 | 1281 | 64392902 |
Coprolalia | 11.03 | 9.76 | 4 | 104545 | 55 | 64394128 |
Pulmonary function test abnormal | 11.01 | 9.76 | 19 | 104530 | 3145 | 64391038 |
Illness | 11.01 | 9.76 | 67 | 104482 | 21871 | 64372312 |
Use of accessory respiratory muscles | 10.98 | 9.76 | 7 | 104542 | 353 | 64393830 |
Relapsing fever | 10.98 | 9.76 | 7 | 104542 | 353 | 64393830 |
Irritable bowel syndrome | 10.97 | 9.76 | 28 | 104521 | 37341 | 64356842 |
Pneumonia aspiration | 10.97 | 9.76 | 54 | 104495 | 59217 | 64334966 |
Device ineffective | 10.90 | 9.76 | 5 | 104544 | 129 | 64394054 |
Neutropenic sepsis | 10.88 | 9.76 | 13 | 104536 | 23259 | 64370924 |
Allergic respiratory disease | 10.84 | 9.76 | 4 | 104545 | 58 | 64394125 |
Osteonecrosis of jaw | 10.82 | 9.76 | 31 | 104518 | 39794 | 64354389 |
Toxic epidermal necrolysis | 10.80 | 9.76 | 28 | 104521 | 37138 | 64357045 |
Perirectal abscess | 10.79 | 9.76 | 14 | 104535 | 1799 | 64392384 |
Carotid arteriosclerosis | 10.77 | 9.76 | 15 | 104534 | 2064 | 64392119 |
Gastrointestinal inflammation | 10.76 | 9.76 | 28 | 104521 | 6167 | 64388016 |
Muscle spasms | 10.72 | 9.76 | 302 | 104247 | 140721 | 64253462 |
Laryngitis fungal | 10.69 | 9.76 | 5 | 104544 | 135 | 64394048 |
Campylobacter gastroenteritis | 10.67 | 9.76 | 11 | 104538 | 1105 | 64393078 |
Lower respiratory tract congestion | 10.59 | 9.76 | 18 | 104531 | 2943 | 64391240 |
Herpes zoster oticus | 10.58 | 9.76 | 7 | 104542 | 376 | 64393807 |
Atelectasis | 10.51 | 9.76 | 78 | 104471 | 27188 | 64366995 |
Granuloma | 10.51 | 9.76 | 29 | 104520 | 6612 | 64387571 |
Cytopenia | 10.50 | 9.76 | 6 | 104543 | 15465 | 64378718 |
Hypercalcaemia | 10.46 | 9.76 | 22 | 104527 | 31394 | 64362789 |
Abdominal adhesions | 10.46 | 9.76 | 18 | 104531 | 2974 | 64391209 |
Renal injury | 10.45 | 9.76 | 6 | 104543 | 15423 | 64378760 |
Leukoplakia oral | 10.42 | 9.76 | 6 | 104543 | 251 | 64393932 |
Bronchospasm paradoxical | 10.39 | 9.76 | 5 | 104544 | 144 | 64394039 |
Sinusitis bacterial | 10.39 | 9.76 | 11 | 104538 | 1139 | 64393044 |
Serotonin syndrome | 10.37 | 9.76 | 31 | 104518 | 39251 | 64354932 |
Infective exacerbation of bronchiectasis | 10.25 | 9.76 | 9 | 104540 | 739 | 64393444 |
Multiple organ dysfunction syndrome | 10.21 | 9.76 | 110 | 104439 | 101303 | 64292880 |
Blood calcium decreased | 10.21 | 9.76 | 16 | 104533 | 25538 | 64368645 |
Blood pressure systolic | 10.20 | 9.76 | 4 | 104545 | 69 | 64394114 |
Akathisia | 10.18 | 9.76 | 3 | 104546 | 11507 | 64382676 |
Nasal discomfort | 10.16 | 9.76 | 22 | 104527 | 4306 | 64389877 |
Functional residual capacity decreased | 10.15 | 9.76 | 4 | 104545 | 70 | 64394113 |
Pulseless electrical activity | 10.09 | 9.76 | 4 | 104545 | 12735 | 64381448 |
Nervousness | 9.98 | 9.76 | 82 | 104467 | 29474 | 64364709 |
Clostridium difficile infection | 9.98 | 9.76 | 96 | 104453 | 36067 | 64358116 |
Tooth disorder | 9.96 | 9.76 | 13 | 104536 | 22389 | 64371794 |
Diarrhoea | 9.94 | 9.76 | 1023 | 103526 | 721681 | 63672502 |
Gastrointestinal mucosa hyperaemia | 9.93 | 9.76 | 7 | 104542 | 417 | 64393766 |
Unevaluable event | 9.93 | 9.76 | 45 | 104504 | 50444 | 64343739 |
Diverticulum | 9.86 | 9.76 | 45 | 104504 | 13153 | 64381030 |
Adenovirus infection | 9.86 | 9.76 | 30 | 104519 | 7225 | 64386958 |
Diabetic ketoacidosis | 9.86 | 9.76 | 21 | 104528 | 29824 | 64364359 |
Febrile bone marrow aplasia | 9.83 | 9.76 | 3 | 104546 | 11252 | 64382931 |
Nocardiosis | 9.82 | 9.76 | 23 | 104526 | 4744 | 64389439 |
Fungal disease carrier | 9.81 | 9.76 | 6 | 104543 | 281 | 64393902 |
Hypertension | 9.80 | 9.76 | 514 | 104035 | 258747 | 64135436 |
Musculoskeletal chest pain | 9.78 | 9.76 | 64 | 104485 | 21415 | 64372768 |
None
Source | Code | Description |
---|---|---|
ATC | A07EA06 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally |
ATC | D07AC09 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
ATC | R01AD05 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
ATC | R03AK07 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AK12 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AL11 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
ATC | R03BA02 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids |
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:35523 | bronchodilator |
CHEBI has role | CHEBI:88188 | allergenic drug |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D005938 | Glucocorticoids |
MeSH PA | D006728 | Hormones |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D019141 | Respiratory System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Crohn's disease | indication | 34000006 | |
Allergic rhinitis | indication | 61582004 | |
Asthma | indication | 195967001 | DOID:2841 |
Eosinophilic esophagitis | indication | 235599003 | DOID:13922 |
Severe chronic obstructive pulmonary disease | indication | 313299006 | |
Asthma management | indication | 406162001 | |
Crohn's disease in remission | indication | 426549001 | |
Chronic Non-Allergic Rhinitis | indication | ||
Allergic Rhinitis Prevention | indication | ||
Infection by Strongyloides | contraindication | 1214006 | DOID:10955 |
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Gastritis | contraindication | 4556007 | DOID:4029 |
Inactive tuberculosis | contraindication | 11999007 | |
Epistaxis | contraindication | 12441001 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Hypercholesterolemia | contraindication | 13644009 | |
Measles | contraindication | 14189004 | DOID:8622 |
Disease caused by parasite | contraindication | 17322007 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Arginase deficiency | contraindication | 23501004 | DOID:9278 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Acute tuberculosis | contraindication | 25629007 | |
Viral disease | contraindication | 34014006 | DOID:934 |
Immunosuppression | contraindication | 38013005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Infectious disease | contraindication | 40733004 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Hypokalemia | contraindication | 43339004 | |
Hypercortisolism | contraindication | 47270006 | |
Chronic heart failure | contraindication | 48447003 | |
Cerebral malaria | contraindication | 53622003 | DOID:14069 |
Tuberculosis | contraindication | 56717001 | |
Congenital hyperammonemia, type I | contraindication | 62522004 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Perforation of nasal septum | contraindication | 80142000 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Bacterial infectious disease | contraindication | 87628006 | |
Muscle atrophy | contraindication | 88092000 | DOID:767 |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Operation on nose | contraindication | 88733004 | |
Bilateral cataracts | contraindication | 95722004 | |
Seizure disorder | contraindication | 128613002 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Pulmonary tuberculosis | contraindication | 154283005 | DOID:2957 |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Anastomosis of intestine | contraindication | 235407009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Edema | contraindication | 267038008 | |
Pathological fracture | contraindication | 268029009 | |
Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
Cerebral trauma | contraindication | 275382005 | |
Varicella-zoster virus infection | contraindication | 309465005 | |
Osteopenia | contraindication | 312894000 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Avascular necrosis of bone | contraindication | 397758007 | DOID:10159 |
Citrullinemia | contraindication | 398680004 | DOID:9273 |
Traumatic rupture of tendon | contraindication | 415749005 | |
Exposure to varicella | contraindication | 444453009 | |
Arginosuccinate Lyase Deficiency | contraindication | ||
Uncontrolled Bacterial Infections | contraindication | ||
Nasal Septal Ulcers | contraindication | ||
Nasal Trauma | contraindication | ||
Untreated Fungal Infection | contraindication | ||
Nasal Candidiasis | contraindication | ||
Oropharyngeal Candidiasis | contraindication | ||
Ornithine Carbamyltransferase Deficiency | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.8 | acidic |
pKa2 | 12.78 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.08MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 10166247 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 7759328 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8143239 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR REDUCING EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
0.16MG/INH;0.0045MG/INH | SYMBICORT | ASTRAZENECA | N021929 | July 21, 2006 | RX | AEROSOL, METERED | INHALATION | 8575137 | Jan. 29, 2023 | USE FOR THE TREATMENT OF ASTHMA IN PATIENTS 6 YEARS OF AGE AND OLDER |
4MG | TARPEYO | CALLIDITAS | N215935 | Dec. 15, 2021 | RX | CAPSULE, DELAYED RELEASE | ORAL | 8491932 | May 7, 2029 | TREATMENT OF PRIMARY IMMUNOGLOBULIN A NEPHROPATHY (IGAN) IN ADULTS AT RISK OF RAPID DISEASE PROGRESSION |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 10716753 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 8324266 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 8703806 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 8808713 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 9415009 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 9463161 | May 28, 2030 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | 8815258 | March 17, 2031 | USE FOR THE MAINTENANCE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) |
9MG | UCERIS | SALIX | N203634 | Jan. 14, 2013 | RX | TABLET, EXTENDED RELEASE | ORAL | 9192581 | Sept. 7, 2031 | INDUCTION OF REMISSION IN PATIENTS WITH ACTIVE, MILD TO MODERATE ULCERATIVE COLITIS |
6MG | ORTIKOS | SUN PHARM INDS INC | N211929 | June 13, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10172802 | Sept. 9, 2036 | TREATMENT OF MILD TO MODERATE ACTIVE CROHNS DISEASE INVOLVING THE ILEUM AND/OR THE ASCENDING COLON |
6MG | ORTIKOS | SUN PHARM INDS INC | N211929 | June 13, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9707182 | Sept. 9, 2036 | TREATMENT OF MILD TO MODERATE ACTIVE CROHNS DISEASE INVOLVING THE ILEUM AND/OR THE ASCENDING COLON |
9MG | ORTIKOS | SUN PHARM INDS INC | N211929 | June 13, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10172802 | Sept. 9, 2036 | TREATMENT OF MILD TO MODERATE ACTIVE CROHNS DISEASE INVOLVING THE ILEUM AND/OR THE ASCENDING COLON |
9MG | ORTIKOS | SUN PHARM INDS INC | N211929 | June 13, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9707182 | Sept. 9, 2036 | TREATMENT OF MILD TO MODERATE ACTIVE CROHNS DISEASE INVOLVING THE ILEUM AND/OR THE ASCENDING COLON |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
0.16MG/INH;0.0048MG/INH;0.009MG/INH | BREZTRI AEROSPHERE | ASTRAZENECA AB | N212122 | July 23, 2020 | RX | AEROSOL, METERED | INHALATION | July 23, 2023 | NEW COMBINATION |
4MG | TARPEYO | CALLIDITAS | N215935 | Dec. 15, 2021 | RX | CAPSULE, DELAYED RELEASE | ORAL | Dec. 15, 2024 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | EC50 | 10.30 | WOMBAT-PK | CHEMBL | |||
Interleukin-5 | Cytokine | IC50 | 9.92 | WOMBAT-PK | |||||
Interferon gamma | Cytokine | IC50 | 9.50 | WOMBAT-PK | |||||
Mineralocorticoid receptor | Nuclear hormone receptor | AGONIST | EC50 | 7.85 | IUPHAR | ||||
Progesterone receptor | Nuclear hormone receptor | AGONIST | EC50 | 7.55 | IUPHAR | ||||
Matrix metalloproteinase-9 | Enzyme | IC50 | 5.70 | DRUG MATRIX | |||||
Multidrug resistance protein 1 | Transporter | WOMBAT-PK | |||||||
Androgen receptor | Transcription factor | Ki | 5.96 | DRUG MATRIX | |||||
Progesterone receptor | Transcription factor | Ki | 7.57 | DRUG MATRIX | |||||
Glucocorticoid receptor | Transcription factor | IC50 | 8.54 | CHEMBL | |||||
Interleukin-5 | Unclassified | IC50 | 4.58 | CHEMBL | |||||
Interleukin-5 receptor subunit alpha | Unclassified | IC50 | 4.58 | CHEMBL |
ID | Source |
---|---|
4020889 | VUID |
N0000148384 | NUI |
D00246 | KEGG_DRUG |
19831 | RXNORM |
C0054201 | UMLSCUI |
CHEBI:3207 | CHEBI |
CHEMBL1370 | ChEMBL_ID |
D019819 | MESH_DESCRIPTOR_UI |
DB01222 | DRUGBANK_ID |
5281004 | PUBCHEM_CID |
7434 | IUPHAR_LIGAND_ID |
4145 | INN_ID |
Q3OKS62Q6X | UNII |
4303 | MMSL |
44092 | MMSL |
d04276 | MMSL |
004214 | NDDF |
108622005 | SNOMEDCT_US |
395726003 | SNOMEDCT_US |
4020889 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6815 | SUSPENSION | 0.25 mg | RESPIRATORY (INHALATION) | ANDA | 26 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6815 | SUSPENSION | 0.25 mg | RESPIRATORY (INHALATION) | ANDA | 26 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6816 | SUSPENSION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 26 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6816 | SUSPENSION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 26 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-6817 | SUSPENSION | 1 mg | RESPIRATORY (INHALATION) | ANDA | 26 sections |
Budesonide Inhalation | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1687 | SUSPENSION | 0.25 mg | RESPIRATORY (INHALATION) | ANDA | 25 sections |
Budesonide Inhalation | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1689 | SUSPENSION | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 25 sections |
SYMBICORT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0186-0370 | AEROSOL | 160 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
SYMBICORT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0186-0372 | AEROSOL | 80 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
PULMICORTFLEXHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-0916 | AEROSOL, POWDER | 180 ug | RESPIRATORY (INHALATION) | NDA | 25 sections |
PULMICORTFLEXHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-0917 | AEROSOL, POWDER | 90 ug | RESPIRATORY (INHALATION) | NDA | 25 sections |
PULMICORT RESPULES | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-1988 | SUSPENSION | 0.25 mg | RESPIRATORY (INHALATION) | NDA | 25 sections |
PULMICORT RESPULES | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-1989 | SUSPENSION | 0.50 mg | RESPIRATORY (INHALATION) | NDA | 25 sections |
PULMICORT RESPULES | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0186-1990 | SUSPENSION | 1 mg | RESPIRATORY (INHALATION) | NDA | 25 sections |
BREZTRI | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0310-4616 | AEROSOL, METERED | 160 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
Budesonide and Formoterol Fumarate Dihydrate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0310-7370 | AEROSOL | 160 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
Budesonide and Formoterol Fumarate Dihydrate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0310-7372 | AEROSOL | 80 ug | RESPIRATORY (INHALATION) | NDA authorized generic | 28 sections |
Budesonide | HUMAN OTC DRUG LABEL | 1 | 0363-0048 | SPRAY, METERED | 32 ug | NASAL | ANDA | 15 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4500 | TABLET, FILM COATED, EXTENDED RELEASE | 9 mg | ORAL | ANDA | 28 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7155 | CAPSULE, DELAYED RELEASE | 3 mg | ORAL | ANDA | 29 sections |
BREYNA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-7502 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | ANDA | 29 sections |
BREYNA | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-7503 | AEROSOL, METERED | 160 ug | RESPIRATORY (INHALATION) | ANDA | 29 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0487-9601 | INHALANT | 0.25 mg | RESPIRATORY (INHALATION) | ANDA | 27 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0487-9701 | INHALANT | 0.50 mg | RESPIRATORY (INHALATION) | ANDA | 27 sections |
Budesonide | HUMAN OTC DRUG LABEL | 1 | 0536-1112 | SPRAY, METERED | 32 ug | NASAL | ANDA | 15 sections |
Entocort EC | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-9850 | CAPSULE | 3 mg | ORAL | NDA | 28 sections |
budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-9855 | CAPSULE | 3 mg | ORAL | NDA | 27 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2510 | TABLET, FILM COATED, EXTENDED RELEASE | 9 mg | ORAL | ANDA | 27 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2510 | TABLET, FILM COATED, EXTENDED RELEASE | 9 mg | ORAL | ANDA | 27 sections |
Budesonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-7515 | SUSPENSION | 0.25 mg | RESPIRATORY (INHALATION) | ANDA | 26 sections |