difluprednate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 3142 23674-86-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • difluprednate
  • durezol
  • Molecular weight: 508.56
  • Formula: C27H34F2O7
  • CLOGP: 3.44
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -4.72
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 23, 2008 FDA ALCON PHARMS LTD

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Vision blurred 113.60 104.37 26 129 14642 2343288

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC D07AC19 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Post-Op Ocular Inflammation indication
Postoperative Ocular Pain indication
Cyclitis off-label use 17657000
Iritis off-label use 65074000 DOID:1406
Iridocyclitis off-label use 77971008
Uveitis off-label use 128473001 DOID:13141
Allergic conjunctivitis off-label use 473460002 DOID:11204
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex dendritic keratitis contraindication 29943008
Tuberculosis of eye contraindication 49107007
Bacterial keratitis contraindication 314557000
Fungal keratitis contraindication 314558005
Vaccinia keratitis contraindication 397552005
Herpes zoster keratitis contraindication 397573005

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.49 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4027694 VUID
N0000179107 NUI
C0058004 UMLSCUI
D01266 KEGG_DRUG
440063000 SNOMEDCT_US
22956 MMSL
23043 RXNORM
4027694 VANDF
438200007 SNOMEDCT_US
005778 NDDF
S8A06QG2QE UNII
2652 INN_ID
DB06781 DRUGBANK_ID
CHEBI:31485 CHEBI
7474 IUPHAR_LIGAND_ID
CHEMBL1201749 ChEMBL_ID
443936 PUBCHEM_CID
C015808 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DUREZOL HUMAN PRESCRIPTION DRUG LABEL 1 0065-9240 EMULSION 0.50 mg OPHTHALMIC NDA 14 sections
DUREZOL HUMAN PRESCRIPTION DRUG LABEL 1 54868-6296 EMULSION 0.50 mg OPHTHALMIC NDA 14 sections