betamethasone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	348	378-44-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: betamethasone betadexamethasone betametasone betamethazone bethamethasone	A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724) Molecular weight: 392.47 Formula: C22H29FO5 CLOGP: 1.78 LIPINSKI: 0 HAC: 5 HDO: 3 TPSA: 94.83 ALOGS: -3.89 ROTB: 2 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

betamethasone
betadexamethasone
betametasone
betamethazone
bethamethasone

A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)

Molecular weight: 392.47
Formula: C22H29FO5
CLOGP: 1.78
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 94.83
ALOGS: -3.89
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1.50	mg	O
1.50	mg	P
0.40	mg	P
0.40	mg	N

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.07 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	4.80 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.38 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	1.30 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.36 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	5.60 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
April 17, 1961	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature delivery	1240.17	14.47	393	13187	23270	50568274
Premature baby	1020.36	14.47	319	13261	18018	50573526
Maternal exposure during pregnancy	726.98	14.47	479	13101	159299	50432245
Low birth weight baby	684.87	14.47	182	13398	5699	50585845
Exposure during pregnancy	619.17	14.47	391	13189	120624	50470920
Foetal exposure during pregnancy	585.29	14.47	234	13346	27125	50564419
Neonatal respiratory distress syndrome	220.25	14.47	63	13517	2591	50588953
Premature labour	203.67	14.47	86	13494	11390	50580154
Foetal growth restriction	167.25	14.47	64	13516	6563	50584981
Patent ductus arteriosus	145.48	14.47	50	13530	3770	50587774
Macular degeneration	136.85	14.47	70	13510	14318	50577226
Pre-eclampsia	115.70	14.47	52	13528	7992	50583552
Computerised tomogram thorax abnormal	111.03	14.47	32	13548	1351	50590193
Steroid withdrawal syndrome	104.54	14.47	25	13555	502	50591042
Caesarean section	101.26	14.47	59	13521	15580	50575964
Live birth	98.63	14.47	59	13521	16349	50575195
Psoriasis	92.54	14.47	103	13477	68897	50522647
Premature rupture of membranes	90.25	14.47	37	13543	4543	50587001
Respiratory disorder neonatal	85.58	14.47	24	13556	917	50590627
Ductus arteriosus premature closure	83.34	14.47	19	13561	307	50591237
Oligohydramnios	78.98	14.47	36	13544	5714	50585830
Gestational diabetes	78.84	14.47	39	13541	7426	50584118
Selective eating disorder	77.69	14.47	26	13554	1806	50589738
Preterm premature rupture of membranes	74.74	14.47	23	13557	1219	50590325
Bradycardia neonatal	65.36	14.47	19	13561	827	50590717
Normal newborn	64.90	14.47	33	13547	6658	50584886
Diabetes mellitus inadequate control	55.90	14.47	38	13542	13107	50578437
Atrial septal defect	54.97	14.47	29	13551	6312	50585232
Weight gain poor	53.87	14.47	16	13564	751	50590793
Atelectasis	53.16	14.47	42	13538	18228	50573316
Foetal hypokinesia	52.28	14.47	14	13566	449	50591095
Skin exfoliation	51.73	14.47	54	13526	33558	50557986
Product use in unapproved indication	49.29	14.47	101	13479	115718	50475826
Bronchopulmonary dysplasia	48.88	14.47	12	13568	270	50591274
Hydrops foetalis	46.47	14.47	12	13568	333	50591211
Placental insufficiency	45.80	14.47	16	13564	1265	50590279
Rectal cancer metastatic	45.17	14.47	11	13569	239	50591305
Computerised tomogram thorax	44.87	14.47	10	13570	145	50591399
Multiple drug therapy	42.82	14.47	17	13563	1920	50589624
Hypoxia	42.33	14.47	60	13520	51063	50540481
Neonatal gastrointestinal haemorrhage	42.24	14.47	7	13573	16	50591528
Cervical incompetence	39.86	14.47	12	13568	590	50590954
Amniotic cavity infection	39.57	14.47	14	13566	1149	50590395
Skin weeping	39.40	14.47	11	13569	413	50591131
Polyhydramnios	38.67	14.47	16	13564	2009	50589535
Foetal distress syndrome	38.64	14.47	14	13566	1231	50590313
Ophthalmic herpes simplex	36.17	14.47	10	13570	362	50591182
Acute pulmonary oedema	35.72	14.47	23	13557	7244	50584300
Infantile apnoea	35.47	14.47	12	13568	861	50590683
Blood pressure inadequately controlled	35.06	14.47	19	13561	4361	50587183
HELLP syndrome	34.87	14.47	12	13568	907	50590637
Starvation ketoacidosis	34.57	14.47	7	13573	62	50591482
Foetal heart rate deceleration abnormality	34.05	14.47	10	13570	451	50591093
Hypotonia neonatal	33.91	14.47	12	13568	985	50590559
Ventricular septal defect	33.66	14.47	18	13562	4023	50587521
Umbilical erythema	33.53	14.47	7	13573	73	50591471
Death	32.47	14.47	24	13556	325355	50266189
Foetal non-stress test abnormal	32.12	14.47	6	13574	33	50591511
Exercise tolerance decreased	30.51	14.47	18	13562	4856	50586688
Off label use	30.22	14.47	224	13356	474202	50117342
Neonatal hypocalcaemia	30.00	14.47	5	13575	12	50591532
Corneal perforation	29.32	14.47	9	13571	473	50591071
Arthropathy	28.99	14.47	4	13576	157902	50433642
Neonatal respiratory failure	27.29	14.47	7	13573	189	50591355
Pneumocystis jirovecii pneumonia	27.05	14.47	26	13554	14637	50576907
Drug intolerance	26.26	14.47	13	13567	219091	50372453
Right ventricular dysfunction	25.32	14.47	11	13569	1557	50589987
Cholestasis of pregnancy	25.26	14.47	10	13570	1121	50590423
Pain	25.25	14.47	76	13504	578827	50012717
Meningitis chemical	24.70	14.47	6	13574	129	50591415
Pulmonary hypoplasia	24.57	14.47	7	13573	283	50591261
Asthenia	24.27	14.47	30	13550	319012	50272532
Cerebral haemorrhage neonatal	24.23	14.47	6	13574	140	50591404
Pneumocephalus	24.23	14.47	6	13574	140	50591404
Pulmonary valve stenosis congenital	23.95	14.47	6	13574	147	50591397
Perioral dermatitis	23.80	14.47	6	13574	151	50591393
Intraventricular haemorrhage neonatal	23.61	14.47	6	13574	156	50591388
Joint swelling	23.30	14.47	19	13561	245267	50346277
Skin infection	23.06	14.47	22	13558	12269	50579275
Maternal condition affecting foetus	22.92	14.47	6	13574	176	50591368
Systemic lupus erythematosus	22.67	14.47	5	13575	140617	50450927
Gastrointestinal disorder	22.57	14.47	66	13514	94390	50497154
Toxic anterior segment syndrome	22.13	14.47	10	13570	1555	50589989
Small for dates baby	22.09	14.47	13	13567	3492	50588052
Breech presentation	21.94	14.47	9	13571	1105	50590439
Gestational hypertension	21.90	14.47	11	13569	2162	50589382
Pulmonary valve disease	21.73	14.47	4	13576	20	50591524
Meconium abnormal	21.67	14.47	3	13577	0	50591544
Death neonatal	21.47	14.47	6	13574	226	50591318
Foetal growth abnormality	21.26	14.47	4	13576	23	50591521
Neonatal intestinal perforation	21.12	14.47	4	13576	24	50591520
Serratia infection	21.07	14.47	8	13572	802	50590742
Glossodynia	21.04	14.47	3	13577	115566	50475978
Libido increased	20.99	14.47	9	13571	1234	50590310
Aplastic anaemia	20.90	14.47	17	13563	7686	50583858
Skin burning sensation	20.58	14.47	19	13561	10166	50581378
Oesophageal atresia	20.46	14.47	7	13573	520	50591024
Tracheo-oesophageal fistula	20.37	14.47	7	13573	527	50591017
Fall	20.14	14.47	37	13543	334895	50256649
Rheumatoid arthritis	20.10	14.47	15	13565	202535	50389009
Therapeutic product effect decreased	19.71	14.47	6	13574	136044	50455500
Angiotensin converting enzyme inhibitor foetopathy	19.69	14.47	4	13576	36	50591508
Delayed delivery	19.60	14.47	4	13576	37	50591507
Soft tissue injury	19.46	14.47	9	13571	1475	50590069
Anaemia neonatal	19.37	14.47	6	13574	325	50591219
Ultrasound uterus abnormal	19.31	14.47	4	13576	40	50591504
Discomfort	19.29	14.47	3	13577	108377	50483167
Retroplacental haematoma	19.05	14.47	5	13575	148	50591396
Infusion related reaction	18.93	14.47	11	13569	169546	50421998
Arthralgia	18.80	14.47	58	13522	438644	50152900
Synovitis	18.80	14.47	5	13575	123860	50467684
Wound	18.67	14.47	3	13577	105791	50485753
Ulcerative keratitis	18.34	14.47	10	13570	2323	50589221
Hostility	17.90	14.47	9	13571	1773	50589771
Sepsis neonatal	17.82	14.47	6	13574	424	50591120
Respiratory failure	17.44	14.47	59	13521	91122	50500422
Post-traumatic neck syndrome	17.31	14.47	9	13571	1901	50589643
Human herpesvirus 6 infection	17.31	14.47	10	13570	2596	50588948
Dry gangrene	17.07	14.47	6	13574	483	50591061
Adrenal haematoma	17.05	14.47	3	13577	11	50591533
Confusional state	16.91	14.47	15	13565	185913	50405631
Sternal fracture	16.91	14.47	9	13571	1993	50589551
Scab	16.79	14.47	14	13566	6548	50584996
Right aortic arch	16.74	14.47	5	13575	239	50591305
Cyanosis neonatal	16.17	14.47	5	13575	269	50591275
Umbilical cord prolapse	15.98	14.47	3	13577	17	50591527
Shared psychotic disorder	15.70	14.47	3	13577	19	50591525
White matter lesion	15.64	14.47	8	13572	1634	50589910
Palmoplantar keratoderma	15.56	14.47	4	13576	109	50591435
Corneal neovascularisation	15.52	14.47	4	13576	110	50591434
Adenovirus infection	15.50	14.47	10	13570	3158	50588386
Twin pregnancy	15.38	14.47	7	13573	1106	50590438
Contusion	15.18	14.47	65	13515	112118	50479426
Toxicity to various agents	15.09	14.47	21	13559	212478	50379066
Impetigo	15.06	14.47	7	13573	1160	50590384
Decreased insulin requirement	14.74	14.47	4	13576	135	50591409
Pulmonary haemorrhage neonatal	14.58	14.47	3	13577	29	50591515
Ultrasound Doppler abnormal	14.52	14.47	4	13576	143	50591401

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature baby	847.05	18.95	280	8574	17000	29548673
Low birth weight baby	506.83	18.95	151	8703	6457	29559216
Foetal exposure during pregnancy	504.03	18.95	231	8623	33636	29532037
Drug eruption	342.29	18.95	143	8711	16598	29549075
Appendicolith	255.69	18.95	77	8777	3403	29562270
Hepatic function abnormal	244.82	18.95	150	8704	39109	29526564
Urticaria	231.59	18.95	164	8690	54496	29511177
Stomatitis	229.33	18.95	141	8713	36972	29528701
Hypersensitivity	210.92	18.95	153	8701	52750	29512923
Appendicitis	192.81	18.95	79	8775	8700	29556973
Epistaxis	182.45	18.95	139	8715	51565	29514108
Muscle spasms	174.56	18.95	149	8705	64933	29500740
Pain in extremity	135.93	18.95	166	8688	110267	29455406
Cardiogenic shock	134.12	18.95	79	8775	19111	29546562
Stress	133.46	18.95	82	8772	21408	29544265
Patent ductus arteriosus	126.39	18.95	44	8810	3087	29562586
Atrial septal defect	105.93	18.95	48	8806	6741	29558932
Ascites	96.28	18.95	83	8771	36536	29529137
Neonatal respiratory distress syndrome	92.95	18.95	37	8817	3773	29561900
Abdominal distension	80.27	18.95	83	8771	45828	29519845
Hyponatraemia	72.42	18.95	95	8759	67538	29498135
Drug ineffective	72.33	18.95	255	8599	362915	29202758
Multiple organ dysfunction syndrome	69.66	18.95	90	8764	63026	29502647
Foetal growth restriction	63.11	18.95	28	8826	3738	29561935
Foetal heart rate deceleration abnormality	45.48	18.95	13	8841	476	29565197
Psoriasis	45.34	18.95	52	8802	32175	29533498
Constipation	41.79	18.95	100	8754	114060	29451613
Ventricular fibrillation	41.78	18.95	36	8818	15797	29549876
Sepsis	40.91	18.95	114	8740	142568	29423105
Toxicity to various agents	40.57	18.95	3	8851	173658	29392015
Polydipsia	40.24	18.95	20	8834	3445	29562228
Steroid withdrawal syndrome	39.99	18.95	10	8844	217	29565456
Hydrops foetalis	39.44	18.95	10	8844	230	29565443
Septum pellucidum agenesis	39.25	18.95	8	8846	65	29565608
Abdominal pain	37.67	18.95	107	8747	135250	29430423
Respiratory disorder neonatal	35.31	18.95	14	8840	1411	29564262
General physical health deterioration	34.33	18.95	87	8767	102770	29462903
Maternal exposure during pregnancy	34.20	18.95	19	8835	4104	29561569
Death	33.47	18.95	32	8822	342052	29223621
Congenital hearing disorder	31.08	18.95	7	8847	95	29565578
Pneumonia	30.98	18.95	182	8672	319990	29245683
Congenital cystic lung	30.11	18.95	8	8846	222	29565451
Perioral dermatitis	29.83	18.95	7	8847	115	29565558
Cryptorchism	27.99	18.95	13	8841	1929	29563744
Neonatal respiratory failure	26.86	18.95	8	8846	339	29565334
Ventricular septal defect	25.86	18.95	15	8839	3514	29562159
Transient aphasia	25.83	18.95	6	8848	94	29565579
Ciliary hyperaemia	25.71	18.95	5	8849	31	29565642
Persistent corneal epithelial defect	25.44	18.95	5	8849	33	29565640
Polyhydramnios	25.01	18.95	7	8847	237	29565436
Anaplastic astrocytoma	24.80	18.95	6	8848	113	29565560
Haemangioma congenital	24.00	18.95	8	8846	491	29565182
Trisomy 21	23.87	18.95	8	8846	499	29565174
Vertical infection transmission	23.75	18.95	4	8850	9	29565664
Hypothalamic pituitary adrenal axis suppression	23.66	18.95	6	8848	138	29565535
Craniosynostosis	23.29	18.95	7	8847	306	29565367
Congenital pulmonary valve atresia	23.16	18.95	5	8849	55	29565618
Large for dates baby	22.98	18.95	9	8845	878	29564795
Skin indentation	22.92	18.95	4	8850	12	29565661
Shared psychotic disorder	22.23	18.95	4	8850	15	29565658
Glioblastoma	22.15	18.95	9	8845	967	29564706
Pyelocaliectasis	21.04	18.95	9	8845	1100	29564573
Glucocorticoid deficiency	20.41	18.95	6	8848	243	29565430
Premature delivery	20.33	18.95	5	8849	101	29565572
Cerebral ventricle dilatation	19.84	18.95	8	8846	842	29564831
Bronchopulmonary dysplasia	19.75	18.95	7	8847	517	29565156
Tachycardia foetal	19.69	18.95	6	8848	275	29565398
Hypertrophic cardiomyopathy	19.58	18.95	8	8846	871	29564802
Congenital herpes simplex infection	19.16	18.95	4	8850	37	29565636

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature delivery	1100.92	13.75	342	17548	18247	64462595
Maternal exposure during pregnancy	717.55	13.75	401	17489	95483	64385359
Exposure during pregnancy	586.56	13.75	327	17563	77348	64403494
Drug eruption	277.34	13.75	154	17736	35982	64444860
Appendicolith	261.56	13.75	77	17813	3392	64477450
Hepatic function abnormal	216.05	13.75	163	17727	64150	64416692
Premature labour	209.34	13.75	79	17811	7541	64473301
Urticaria	165.63	13.75	204	17686	147113	64333729
Appendicitis	165.40	13.75	79	17811	13490	64467352
Epistaxis	135.37	13.75	151	17739	97980	64382862
Psoriasis	117.66	13.75	121	17769	71582	64409260
Steroid withdrawal syndrome	113.47	13.75	28	17862	622	64480220
Stomatitis	112.30	13.75	145	17745	109460	64371382
Pre-eclampsia	106.73	13.75	46	17844	6185	64474657
Caesarean section	105.90	13.75	55	17835	11219	64469623
Muscle spasms	104.91	13.75	160	17730	140863	64339979
Live birth	103.36	13.75	54	17836	11150	64469692
Computerised tomogram thorax abnormal	98.83	13.75	32	17858	1937	64478905
Cardiogenic shock	97.46	13.75	77	17813	32350	64448492
Hypersensitivity	91.23	13.75	181	17709	196271	64284571
Premature baby	82.94	13.75	32	17858	3240	64477602
Premature rupture of membranes	82.21	13.75	33	17857	3711	64477131
Ascites	79.64	13.75	92	17798	61909	64418933
Gestational diabetes	78.80	13.75	36	17854	5554	64475288
Stress	78.05	13.75	90	17800	60444	64420398
Preterm premature rupture of membranes	71.68	13.75	22	17868	1117	64479725
Normal newborn	66.30	13.75	32	17858	5585	64475257
Drug ineffective	62.02	13.75	421	17469	839826	63641016
Abdominal distension	59.11	13.75	100	17790	95894	64384948
Skin exfoliation	58.29	13.75	67	17823	44818	64436024
Multiple organ dysfunction syndrome	55.11	13.75	100	17790	101313	64379529
Pain in extremity	54.33	13.75	196	17694	302889	64177953
Perioral dermatitis	53.97	13.75	13	17877	260	64480582
Skin weeping	52.11	13.75	15	17875	609	64480233
Oligohydramnios	50.03	13.75	22	17868	3102	64477740
Foetal growth restriction	47.73	13.75	18	17872	1712	64479130
Corneal endotheliitis	46.53	13.75	9	17881	59	64480783
Toxicity to various agents	45.51	13.75	22	17868	363491	64117351
Death	44.61	13.75	41	17849	482664	63998178
Computerised tomogram thorax	44.48	13.75	10	17880	146	64480696
Ophthalmic herpes simplex	44.17	13.75	13	17877	571	64480271
Off label use	42.94	13.75	311	17579	632495	63848347
Atelectasis	42.86	13.75	45	17845	27221	64453621
Product use in unapproved indication	42.19	13.75	126	17764	176492	64304350
Placental insufficiency	40.91	13.75	14	17876	1006	64479836
Ulcerative keratitis	40.70	13.75	19	17871	3078	64477764
Pneumocystis jirovecii pneumonia	40.59	13.75	44	17846	27590	64453252
Amniotic cavity infection	40.57	13.75	13	17877	761	64480081
Polyhydramnios	39.32	13.75	15	17875	1472	64479370
Rectal cancer metastatic	38.42	13.75	11	17879	438	64480404
HELLP syndrome	37.70	13.75	12	17878	687	64480155
Shared psychotic disorder	37.02	13.75	7	17883	40	64480802
Diabetes mellitus inadequate control	36.79	13.75	37	17853	21284	64459558
Multiple drug therapy	36.51	13.75	16	17874	2238	64478604
Ventricular fibrillation	35.06	13.75	38	17852	23822	64457020
Polydipsia	34.50	13.75	21	17869	5800	64475042
Corneal perforation	33.85	13.75	11	17879	673	64480169
Hypothalamic pituitary adrenal axis suppression	33.42	13.75	9	17881	285	64480557
Hyponatraemia	32.77	13.75	103	17787	148236	64332606
Cervical incompetence	32.69	13.75	10	17880	502	64480340
Pulmonary valve stenosis congenital	32.49	13.75	5	17885	5	64480837
Sepsis	32.32	13.75	138	17752	230203	64250639
Cerebral haemorrhage neonatal	32.01	13.75	5	17885	6	64480836
Foetal exposure during pregnancy	31.38	13.75	18	17872	4458	64476384
Asthenia	31.21	13.75	44	17846	428000	64052842
Starvation ketoacidosis	30.53	13.75	7	17883	112	64480730
Blood pressure inadequately controlled	28.31	13.75	18	17872	5366	64475476
Cholestasis of pregnancy	26.89	13.75	10	17880	915	64479927
Constipation	26.65	13.75	130	17760	229207	64251635
Scab	26.18	13.75	21	17869	9001	64471841
Gastrointestinal disorder	25.30	13.75	68	17822	89641	64391201
Skin burning sensation	25.26	13.75	22	17868	10561	64470281
Gestational hypertension	24.24	13.75	11	17879	1670	64479172
Persistent corneal epithelial defect	24.16	13.75	5	17885	48	64480794
Maternal condition affecting foetus	24.11	13.75	6	17884	138	64480704
Drug abuse	23.88	13.75	4	17886	132370	64348472
Anaplastic astrocytoma	23.83	13.75	6	17884	145	64480697
Acute pulmonary oedema	23.52	13.75	23	17867	12786	64468056
Foetal hypokinesia	23.47	13.75	7	17883	322	64480520
Transient aphasia	23.02	13.75	6	17884	167	64480675
Ciliary hyperaemia	22.78	13.75	5	17885	65	64480777
Exercise tolerance decreased	22.49	13.75	18	17872	7692	64473150
Meningitis chemical	21.98	13.75	6	17884	200	64480642
Atrial septal defect	21.29	13.75	10	17880	1643	64479199
Foetal distress syndrome	21.28	13.75	7	17883	445	64480397
Delayed delivery	21.13	13.75	4	17886	23	64480819
Pneumocephalus	20.95	13.75	6	17884	239	64480603
Patent ductus arteriosus	20.76	13.75	5	17885	100	64480742
Fall	20.61	13.75	54	17836	416772	64064070
Skin infection	20.45	13.75	23	17867	15014	64465828
Retroplacental haematoma	20.09	13.75	5	17885	115	64480727
Glucocorticoid deficiency	19.86	13.75	7	17883	549	64480293
Low birth weight baby	19.84	13.75	7	17883	551	64480291
Glioblastoma	19.31	13.75	9	17881	1452	64479390
Hypoxia	19.26	13.75	61	17829	88088	64392754
Joint swelling	19.02	13.75	19	17871	215363	64265479
Soft tissue injury	18.65	13.75	9	17881	1570	64479272
Drug intolerance	18.49	13.75	15	17875	187977	64292865
Acute kidney injury	18.07	13.75	64	17826	449176	64031666
Anaemia	18.01	13.75	50	17840	378630	64102212
Arthralgia	17.79	13.75	63	17827	442197	64038645
Cardiac failure congestive	17.74	13.75	7	17883	130573	64350269
Pharyngeal erythema	17.72	13.75	9	17881	1750	64479092
General physical health deterioration	17.72	13.75	107	17783	204318	64276524
Toxic anterior segment syndrome	17.61	13.75	10	17880	2429	64478413
Libido increased	17.58	13.75	9	17881	1781	64479061
Haemoglobin decreased	17.46	13.75	17	17873	195046	64285796
Adrenal insufficiency	17.37	13.75	26	17864	22461	64458381
Arthropathy	17.25	13.75	6	17884	120961	64359881
Ventricular septal defect	17.12	13.75	6	17884	463	64480379
Post-traumatic neck syndrome	17.06	13.75	9	17881	1893	64478949
Twin pregnancy	17.00	13.75	7	17883	840	64480002
Umbilical cord prolapse	16.95	13.75	3	17887	11	64480831
Familial mediterranean fever	16.65	13.75	4	17886	79	64480763
Abdominal pain	16.40	13.75	145	17745	312230	64168612
Rheumatoid arthritis	16.29	13.75	13	17877	164281	64316561
Foetal heart rate deceleration abnormality	16.20	13.75	4	17886	89	64480753
Dehydration	16.05	13.75	22	17868	216741	64264101
Serratia infection	16.00	13.75	8	17882	1505	64479337
Arthritis allergic	15.89	13.75	3	17887	17	64480825
Hostility	15.81	13.75	9	17881	2198	64478644
Synovitis	15.79	13.75	4	17886	99086	64381756
Dermatitis atopic	15.66	13.75	11	17879	3865	64476977
Sternal fracture	15.66	13.75	9	17881	2238	64478604
Hypotension	15.49	13.75	54	17836	380920	64099922
Corneal oedema	15.31	13.75	9	17881	2334	64478508
Pain	15.04	13.75	91	17799	553420	63927422
Hypertension	15.01	13.75	123	17767	259138	64221704
Impetigo	14.67	13.75	8	17882	1798	64479044
Endophthalmitis	14.54	13.75	12	17878	5353	64475489
Corneal neovascularisation	14.28	13.75	4	17886	147	64480695
Decreased insulin requirement	14.28	13.75	4	17886	147	64480695
Contusion	14.23	13.75	66	17824	113899	64366943
Nausea	13.99	13.75	300	17590	785500	63695342
Palmoplantar keratoderma	13.85	13.75	5	17885	421	64480421

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A07EA04	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally
ATC	C05AA05	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Corticosteroids
ATC	D07AC01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III)
ATC	D07BC01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, potent, combinations with antiseptics
ATC	D07CC01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, potent, combinations with antibiotics
ATC	D07XC01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, potent, other combinations
ATC	H02AB01	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Glucocorticoids
ATC	R01AD06	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids
ATC	R03BA04	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids
ATC	S01BA06	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain
ATC	S01BB04	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids and mydriatics in combination
ATC	S01CA05	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination
ATC	S01CB04	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids/antiinfectives/mydriatics in combination
ATC	S02BA07	SENSORY ORGANS OTOLOGICALS CORTICOSTEROIDS Corticosteroids
ATC	S03BA03	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS CORTICOSTEROIDS Corticosteroids
ATC	S03CA06	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:35705	immunosuppressive agents
CHEBI has role	CHEBI:65023	anti-asthmatic agents
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones
MeSH PA	D019141	Respiratory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Disorder of musculoskeletal system	indication	928000	DOID:17
Cerebral edema	indication	2032001
Tinea pedis	indication	6020002	DOID:12403
Berylliosis	indication	8247009	DOID:10322
Psoriasis	indication	9014002	DOID:8893
Ankylosing spondylitis	indication	9631008	DOID:7147
Rheumatic heart disease	indication	23685000
Atopic dermatitis	indication	24079001	DOID:3310
Inflammatory bowel disease	indication	24526004	DOID:0050589
Multiple sclerosis	indication	24700007	DOID:2377
Severe adrenal insufficiency	indication	24867002
Sarcoidosis	indication	31541009	DOID:11335
Idiopathic thrombocytopenic purpura	indication	32273002	DOID:8924
Psoriasis with arthropathy	indication	33339001
Crohn's disease	indication	34000006
Tendinitis	indication	34840004	DOID:971
Erythema multiforme	indication	36715001
Contact dermatitis	indication	40275004	DOID:2773
Angioedema	indication	41291007	DOID:1558
Miliary tuberculosis	indication	47604008	DOID:9861
Humoral hypercalcemia of malignancy	indication	47709007
Articular gout	indication	48440001	DOID:13189
Seborrheic dermatitis	indication	50563003	DOID:8741
Edema of larynx	indication	51599000
Nephrotic syndrome	indication	52254009	DOID:1184
Lichen simplex chronicus	indication	53891004
Systemic lupus erythematosus	indication	55464009	DOID:9074
Allergic rhinitis	indication	61582004
Löffler's syndrome	indication	64936001	DOID:9503
Pemphigus	indication	65172003	DOID:9182
Granuloma annulare	indication	65508009	DOID:3777
Tenosynovitis	indication	67801009	DOID:970
Rheumatoid arthritis	indication	69896004	DOID:7148
Transfusion reaction due to serum protein reaction	indication	72284000
Epicondylitis	indication	73583000	DOID:14087
Acquired thrombocytopenia	indication	74576004	DOID:11126
Thyroiditis	indication	82119001	DOID:7166
Bursitis	indication	84017003	DOID:2965
Tinea corporis	indication	84849002
Autoimmune disease	indication	85828009
Infection by larvae of Trichinella spiralis	indication	88264003
Congenital hypoplastic anemia	indication	88854002	DOID:1339
Pruritus ani	indication	90446007
Acute lymphoid leukemia	indication	91857003	DOID:9952
Disorder of skin	indication	95320005	DOID:37
Dermatitis herpetiformis	indication	111196000	DOID:8505
Hodgkin's disease	indication	118599009
Non-Hodgkin's lymphoma	indication	118601006
Mycosis fungoides	indication	118618005
Aspiration pneumonitis	indication	155597006
Asthma	indication	195967001	DOID:2841
Discoid lupus erythematosus	indication	200938002
Plaque psoriasis	indication	200965009
Transplanted organ rejection	indication	213148006
Congenital adrenal hyperplasia	indication	237751000
Scalp psoriasis	indication	238608008
Adrenogenital disorder	indication	267395000	DOID:0050811
Pruritus of genital organs	indication	267802000
Eruption of skin	indication	271807003	DOID:0050486
Follicular non-Hodgkin's lymphoma	indication	308121000
Disorder of eye	indication	371405004	DOID:5614
Primary adrenocortical insufficiency	indication	373662000
Adrenal cortical hypofunction	indication	386584007	DOID:10493
Tinea cruris	indication	399029005
Erythroderma	indication	399992009
Primary cutaneous T-cell lymphoma	indication	400122007
Dermatosis of scalp	indication	402694007	DOID:3136
Juvenile rheumatoid arthritis	indication	410795001
Autoimmune hemolytic anemia	indication	413603009	DOID:718
Synovitis	indication	416209007	DOID:2703
Post traumatic osteoarthritis	indication	699262001
Diagnostic Test for Cushing's Syndrome	indication
Systemic Dermatomyositis	indication
Synovitis due to Osteoarthritis	indication
Erythroblastic Anemia	indication
Transfusion Reaction Urticaria	indication
Pericarditis	off-label use	3238004	DOID:1787
Chronic obstructive lung disease	off-label use	13645005	DOID:3083
West syndrome	off-label use	28055006
Vasculitis	off-label use	31996006	DOID:865
Bronchitis	off-label use	32398004	DOID:6132
Eczema	off-label use	43116000
Respiratory distress syndrome in the newborn	off-label use	46775006
Nasal polyp	off-label use	52756005
Rheumatic fever	off-label use	58718002	DOID:1586
Pseudogout	off-label use	60782007
Polymyalgia rheumatica	off-label use	65323003	DOID:853
Chronic hepatitis	off-label use	76783007	DOID:2237
Pemphigoid	off-label use	86142006
Hepatic necrosis	off-label use	87248009
Multiple myeloma	off-label use	109989006	DOID:9538
Polyarteritis nodosa	off-label use	155441006	DOID:9810
Celiac disease	off-label use	396331005	DOID:10608
Carditis	off-label use	399617002
Giant cell arteritis	off-label use	414341000	DOID:13375
Neonatal Bronchopulmonary Dysplasia	off-label use
Hypercalcemia associated with Sarcoidosis	off-label use
Infection by Strongyloides	contraindication	1214006	DOID:10955
Mycosis	contraindication	3218000	DOID:1564
Gastritis	contraindication	4556007	DOID:4029
Inactive tuberculosis	contraindication	11999007
Congenital ichthyosis of skin	contraindication	13059002
Peptic ulcer	contraindication	13200003	DOID:750
Hypercholesterolemia	contraindication	13644009
Measles	contraindication	14189004	DOID:8622
Cirrhosis of liver	contraindication	19943007	DOID:5082
Arginase deficiency	contraindication	23501004	DOID:9278
Hypervitaminosis D	contraindication	27712000	DOID:9971
Guttate psoriasis	contraindication	37042000
Immunosuppression	contraindication	38013005
Hypertensive disorder	contraindication	38341003	DOID:10763
Infectious disease	contraindication	40733004
Hypothyroidism	contraindication	40930008	DOID:1459
Hypokalemia	contraindication	43339004
Chronic heart failure	contraindication	48447003
Cerebral malaria	contraindication	53622003	DOID:14069
Tuberculosis	contraindication	56717001
Congenital hyperammonemia, type I	contraindication	62522004
Osteoporosis	contraindication	64859006	DOID:11476
Hypercalcemia	contraindication	66931009	DOID:12678
Psychotic disorder	contraindication	69322001
Disorder of calcium metabolism	contraindication	71638002	DOID:10575
Hypercalciuria	contraindication	71938000
Diabetes mellitus	contraindication	73211009	DOID:9351
Hypopituitarism	contraindication	74728003	DOID:9406
Hyperglycemia	contraindication	80394007	DOID:4195
Open-angle glaucoma	contraindication	84494001	DOID:1067
Muscle atrophy	contraindication	88092000	DOID:767
Herpes simplex	contraindication	88594005	DOID:8566
Bilateral cataracts	contraindication	95722004
Seizure disorder	contraindication	128613002
Disorder of muscle	contraindication	129565002	DOID:423
Ophthalmic herpes simplex	contraindication	186542001
Pustular psoriasis	contraindication	200973000
Anastomosis of intestine	contraindication	235407009
Telangiectasia disorder	contraindication	247479008
Edema	contraindication	267038008
Pathological fracture	contraindication	268029009
Diverticulitis of gastrointestinal tract	contraindication	271366000
Cerebral trauma	contraindication	275382005
Varicella-zoster virus infection	contraindication	309465005
Osteopenia	contraindication	312894000
Avascular necrosis of bone	contraindication	397758007	DOID:10159
Citrullinemia	contraindication	398680004	DOID:9273
Atrophoderma	contraindication	399979006
Peripheral vascular disease	contraindication	400047006
Traumatic rupture of tendon	contraindication	415749005
Exposure to varicella	contraindication	444453009
Ornithine Carbamyltransferase Deficiency	contraindication
Arginosuccinate Lyase Deficiency	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.06	acidic
pKa2	12.45	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	IC50	8.07		WOMBAT-PK	CHEMBL
Annexin A1	Cytosolic other	P04083	ANXA1_HUMAN					WOMBAT-PK

External reference:

ID	Source
4018644	VUID
N0000146957	NUI
D00244	KEGG_DRUG
1514	RXNORM
C0005308	UMLSCUI
CHEBI:3077	CHEBI
CHEMBL632	ChEMBL_ID
D001623	MESH_DESCRIPTOR_UI
DB00443	DRUGBANK_ID
7061	IUPHAR_LIGAND_ID
1045	INN_ID
9842X06Q6M	UNII
9782	PUBCHEM_CID
10006	MMSL
4270	MMSL
d00628	MMSL
002168	NDDF
4018644	VANDF
116571008	SNOMEDCT_US
29896003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
DR. THROWERS BETA	HUMAN PRESCRIPTION DRUG LABEL	1	69299-202	OINTMENT	0.05 g	TOPICAL	unapproved drug other	4 sections