betamethasone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 348 378-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betamethasone
  • betadexamethasone
  • betametasone
  • betamethazone
  • bethamethasone
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P
0.40 mg P
0.40 mg N

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.07 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.38 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.36 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 17, 1961 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 1095.44 12.04 400 19721 25704 53303241
Premature baby 1092.66 12.04 372 19749 19429 53309516
Exposure during pregnancy 852.76 12.04 549 19572 124311 53204634
Foetal exposure during pregnancy 832.53 12.04 355 19766 34360 53294585
Low birth weight baby 649.04 12.04 191 19930 6146 53322799
Maternal exposure during pregnancy 632.51 12.04 499 19622 155140 53173805
Premature labour 317.73 12.04 133 19988 12229 53316716
Caesarean section 265.71 12.04 130 19991 17190 53311755
Neonatal respiratory distress syndrome 246.86 12.04 76 20045 2851 53326094
Foetal growth restriction 177.00 12.04 75 20046 7099 53321846
Psoriasis 152.80 12.04 176 19945 86913 53242032
Patent ductus arteriosus 142.81 12.04 55 20066 4063 53324882
Pre-eclampsia 121.00 12.04 61 20060 8586 53320359
Steroid withdrawal syndrome 103.68 12.04 27 20094 544 53328401
Live birth 101.65 12.04 66 20055 14993 53313952
Oligohydramnios 94.31 12.04 46 20075 6030 53322915
Premature rupture of membranes 90.75 12.04 42 20079 4898 53324047
Gestational diabetes 87.66 12.04 48 20073 7991 53320954
Ductus arteriosus premature closure 80.39 12.04 20 20101 333 53328612
Computerised tomogram thorax abnormal 79.78 12.04 27 20094 1373 53327572
Macular degeneration 78.13 12.04 52 20069 12309 53316636
Respiratory disorder neonatal 76.33 12.04 24 20097 965 53327980
Maternal drugs affecting foetus 74.31 12.04 38 20083 5508 53323437
Bradycardia neonatal 74.22 12.04 23 20098 881 53328064
Acute pulmonary oedema 73.05 12.04 43 20078 8212 53320733
Selective eating disorder 67.35 12.04 26 20095 1932 53327013
Rheumatoid arthritis 66.94 12.04 18 20103 314513 53014432
Preterm premature rupture of membranes 65.28 12.04 23 20098 1320 53327625
Normal newborn 59.88 12.04 36 20085 7143 53321802
Foetal hypokinesia 59.29 12.04 17 20104 496 53328449
Skin exfoliation 58.33 12.04 70 20051 36013 53292932
Polyhydramnios 57.33 12.04 24 20097 2201 53326744
Cholestasis of pregnancy 56.09 12.04 20 20101 1189 53327756
Atrial septal defect 55.94 12.04 34 20087 6880 53322065
Diabetes mellitus inadequate control 53.76 12.04 44 20077 14266 53314679
Placental insufficiency 53.56 12.04 20 20101 1356 53327589
Bronchopulmonary dysplasia 53.21 12.04 14 20107 294 53328651
Death 50.15 12.04 37 20084 357195 52971750
Multiple drug therapy 48.93 12.04 19 20102 1434 53327511
Ventricular septal defect 47.49 12.04 26 20095 4324 53324621
Weight gain poor 47.23 12.04 16 20105 816 53328129
Toxic anterior segment syndrome 46.38 12.04 21 20100 2327 53326618
Hydrops foetalis 46.09 12.04 13 20108 357 53328588
Infantile apnoea 45.12 12.04 16 20105 936 53328009
Amniotic cavity infection 44.16 12.04 17 20104 1253 53327692
Hypoxia 44.12 12.04 77 20044 55603 53273342
Skin weeping 41.99 12.04 12 20109 346 53328599
Atelectasis 41.31 12.04 44 20077 19882 53309063
Rectal cancer metastatic 40.65 12.04 11 20110 258 53328687
Hypotonia neonatal 39.60 12.04 15 20106 1058 53327887
Foetal distress syndrome 39.39 12.04 16 20105 1359 53327586
Drug intolerance 37.97 12.04 15 20106 205478 53123467
Foetal heart rate deceleration abnormality 37.94 12.04 12 20109 492 53328453
HELLP syndrome 37.31 12.04 14 20107 962 53327983
Pneumocystis jirovecii pneumonia 37.24 12.04 38 20083 16340 53312605
Ophthalmic herpes simplex 35.94 12.04 11 20110 404 53328541
Cervical incompetence 35.07 12.04 12 20109 631 53328314
Arthropathy 34.30 12.04 6 20115 141447 53187498
Blood pressure inadequately controlled 31.85 12.04 21 20100 4890 53324055
Systemic lupus erythematosus 31.11 12.04 5 20116 125409 53203536
Starvation ketoacidosis 31.07 12.04 7 20114 74 53328871
Foetal disorder 31.05 12.04 9 20112 273 53328672
Foetal non-stress test abnormal 30.08 12.04 6 20115 33 53328912
Fall 29.99 12.04 56 20065 358384 52970561
Umbilical erythema 29.67 12.04 7 20114 92 53328853
Small for dates baby 29.20 12.04 18 20103 3734 53325211
Neonatal respiratory failure 28.71 12.04 8 20113 210 53328735
Neonatal hypocalcaemia 28.30 12.04 5 20116 12 53328933
Exercise tolerance decreased 28.09 12.04 20 20101 5275 53323670
Asthenia 27.59 12.04 55 20066 343535 52985410
Death neonatal 27.37 12.04 8 20113 250 53328695
Adrenal suppression 26.79 12.04 11 20110 961 53327984
Cerebral haemorrhage neonatal 26.79 12.04 7 20114 143 53328802
Disseminated intravascular coagulation 26.67 12.04 35 20086 19684 53309261
Vanishing bile duct syndrome 26.62 12.04 10 20111 689 53328256
Pneumocephalus 26.47 12.04 7 20114 150 53328795
Infusion related reaction 26.25 12.04 13 20108 155944 53173001
Product use in unapproved indication 25.81 12.04 97 20024 112192 53216753
Corneal perforation 25.74 12.04 9 20112 505 53328440
Ulcerative keratitis 24.88 12.04 14 20107 2455 53326490
Glossodynia 24.87 12.04 4 20117 100287 53228658
Skin infection 24.35 12.04 27 20094 12755 53316190
Twin pregnancy 24.13 12.04 11 20110 1238 53327707
Interstitial lung disease 24.08 12.04 62 20059 58560 53270385
Perioral dermatitis 24.05 12.04 6 20115 101 53328844
Fatigue 23.23 12.04 171 19950 730335 52598610
Eczema 22.57 12.04 36 20085 24146 53304799
Cushing's syndrome 22.34 12.04 9 20112 748 53328197
Meningitis chemical 22.12 12.04 6 20115 142 53328803
Pulmonary hypoplasia 21.92 12.04 7 20114 296 53328649
Right ventricular dysfunction 21.42 12.04 11 20110 1608 53327337
Pulmonary valve stenosis congenital 21.40 12.04 6 20115 161 53328784
Synovitis 21.40 12.04 7 20114 107886 53221059
Anaemia neonatal 20.91 12.04 7 20114 344 53328601
Intraventricular haemorrhage neonatal 20.64 12.04 6 20115 184 53328761
Serratia infection 20.58 12.04 9 20112 919 53328026
Maternal condition affecting foetus 20.39 12.04 6 20115 192 53328753
Contraindicated product administered 20.38 12.04 13 20108 135616 53193329
Pulmonary valve disease 20.37 12.04 4 20117 20 53328925
Foetal growth abnormality 20.37 12.04 4 20117 20 53328925
Computerised tomogram thorax 20.34 12.04 5 20116 79 53328866
Gestational hypertension 20.24 12.04 12 20109 2321 53326624
Pulmonary oedema 20.21 12.04 55 20066 53668 53275277
Hypoglycaemia neonatal 19.75 12.04 9 20112 1012 53327933
Toxicity to various agents 19.52 12.04 33 20088 219565 53109380
Apgar score low 19.47 12.04 8 20113 700 53328245
Therapeutic product effect decreased 18.94 12.04 12 20109 125643 53203302
Vomiting 18.46 12.04 111 20010 497028 52831917
Cyanosis neonatal 18.41 12.04 6 20115 271 53328674
Proteinuria 18.39 12.04 28 20093 18040 53310905
Confusional state 18.38 12.04 28 20093 194193 53134752
Angiotensin converting enzyme inhibitor foetopathy 18.34 12.04 4 20117 36 53328909
Hepatic function abnormal 18.33 12.04 42 20079 36857 53292088
Delayed delivery 18.24 12.04 4 20117 37 53328908
Neonatal gastrointestinal haemorrhage 18.11 12.04 3 20118 4 53328941
Pain 18.06 12.04 139 19982 588259 52740686
Wound 18.05 12.04 6 20115 91551 53237394
Skin burning sensation 17.90 12.04 22 20099 11588 53317357
Drug hypersensitivity 17.60 12.04 47 20074 265195 53063750
Joint swelling 17.60 12.04 39 20082 234599 53094346
Discomfort 17.56 12.04 7 20114 95465 53233480
Oesophageal atresia 17.36 12.04 7 20114 583 53328362
Tracheo-oesophageal fistula 17.26 12.04 7 20114 592 53328353
Retroplacental haematoma 17.15 12.04 5 20116 155 53328790
Single functional kidney 17.12 12.04 5 20116 156 53328789
Pemphigus 17.01 12.04 9 20112 104022 53224923
Ultrasound uterus abnormal 16.86 12.04 4 20117 54 53328891
Diarrhoea 16.84 12.04 153 19968 625393 52703552
Adrenal haematoma 16.76 12.04 3 20118 8 53328937
Toxic epidermal necrolysis 16.64 12.04 31 20090 23519 53305426
Aplastic anaemia 16.58 12.04 18 20103 8303 53320642
Skin plaque 16.46 12.04 16 20105 6488 53322457
Bradycardia foetal 16.30 12.04 6 20115 391 53328554
Female sex hormone level abnormal 15.28 12.04 3 20118 15 53328930
Scab 15.26 12.04 16 20105 7097 53321848
Adrenal insufficiency 15.12 12.04 23 20098 14806 53314139
Sepsis neonatal 15.10 12.04 6 20115 481 53328464
Persistent foetal circulation 15.09 12.04 5 20116 238 53328707
Haemangioma congenital 14.93 12.04 6 20115 496 53328449
Shared psychotic disorder 14.68 12.04 3 20118 19 53328926
Placenta praevia haemorrhage 14.66 12.04 4 20117 97 53328848
Blood corticotrophin decreased 14.57 12.04 5 20116 265 53328680
Human herpesvirus 6 infection 14.45 12.04 10 20111 2520 53326425
Right aortic arch 14.41 12.04 5 20116 274 53328671
Dry gangrene 14.30 12.04 6 20115 553 53328392
Hypopituitarism 14.22 12.04 7 20114 936 53328009
Uterine contractions during pregnancy 14.21 12.04 6 20115 562 53328383
Jaundice neonatal 14.21 12.04 7 20114 937 53328008
ACTH stimulation test abnormal 14.18 12.04 3 20118 23 53328922
Umbilical cord prolapse 14.18 12.04 3 20118 23 53328922
Hepatic enzyme increased 14.18 12.04 16 20105 126179 53202766
Hypotension 14.02 12.04 49 20072 254027 53074918
Palmoplantar keratoderma 14.01 12.04 4 20117 115 53328830
Acute kidney injury 13.98 12.04 49 20072 253819 53075126
Corneal neovascularisation 13.88 12.04 4 20117 119 53328826
Induced labour 13.87 12.04 7 20114 986 53327959
Treatment failure 13.66 12.04 17 20104 128386 53200559
Respiratory failure 13.44 12.04 74 20047 100438 53228507
Arthralgia 13.42 12.04 104 20017 439679 52889266
Decreased insulin requirement 13.39 12.04 4 20117 135 53328810
Neonatal sinus tachycardia 13.38 12.04 3 20118 31 53328914
Umbilical artery vascular resistance increased 13.38 12.04 3 20118 31 53328914
Neonatal disorder 13.31 12.04 6 20115 658 53328287
Pulmonary haemorrhage neonatal 13.29 12.04 3 20118 32 53328913
White matter lesion 13.17 12.04 8 20113 1616 53327329
Neutropenia 13.17 12.04 25 20096 159160 53169785
Pharyngeal erythema 13.09 12.04 8 20113 1633 53327312
Psoriatic arthropathy 13.09 12.04 44 20077 48146 53280799
Neonatal hypotension 13.07 12.04 4 20117 147 53328798
Neonatal cholestasis 13.05 12.04 3 20118 35 53328910
Enlarged clitoris 13.04 12.04 4 20117 148 53328797
Ultrasound Doppler abnormal 12.99 12.04 4 20117 150 53328795
Skin atrophy 12.84 12.04 12 20109 4634 53324311
Foetal heart rate decreased 12.79 12.04 4 20117 158 53328787
Hypothalamic pituitary adrenal axis suppression 12.74 12.04 4 20117 160 53328785
Stevens-Johnson syndrome 12.23 12.04 28 20093 24554 53304391
Adenovirus infection 12.19 12.04 10 20111 3252 53325693
Neonatal anuria 12.17 12.04 3 20118 48 53328897
Decreased appetite 12.16 12.04 41 20080 214933 53114012
Premature separation of placenta 12.15 12.04 8 20113 1859 53327086

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 841.86 13.70 309 13259 18209 32481749
Foetal exposure during pregnancy 701.01 13.70 342 13226 40959 32458999
Low birth weight baby 464.48 13.70 155 13413 6839 32493119
Drug eruption 298.46 13.70 150 13418 19016 32480942
Hepatic function abnormal 251.72 13.70 182 13386 44658 32455300
Appendicolith 201.49 13.70 68 13500 3097 32496861
Stomatitis 200.36 13.70 152 13416 40077 32459881
Urticaria 194.07 13.70 176 13392 59438 32440520
Hypersensitivity 175.31 13.70 164 13404 57594 32442364
Patent ductus arteriosus 156.96 13.70 57 13511 3228 32496730
Appendicitis 148.02 13.70 73 13495 8864 32491094
Epistaxis 142.07 13.70 144 13424 55711 32444247
Muscle spasms 124.44 13.70 150 13418 70268 32429690
Psoriasis 113.76 13.70 117 13451 46006 32453952
Neonatal respiratory distress syndrome 113.30 13.70 48 13520 4099 32495859
Pain in extremity 111.42 13.70 187 13381 118714 32381244
Atrial septal defect 109.28 13.70 55 13513 6970 32492988
Stress 94.98 13.70 79 13489 23703 32476255
Foetal growth restriction 91.86 13.70 41 13527 3971 32495987
Cardiogenic shock 87.46 13.70 71 13497 20591 32479367
Ascites 60.35 13.70 79 13489 40112 32459846
Toxicity to various agents 55.98 13.70 5 13563 178036 32321922
Caesarean section 55.91 13.70 24 13544 2115 32497843
Death 54.41 13.70 48 13520 382469 32117489
Abdominal distension 49.67 13.70 82 13486 51213 32448745
Apgar score low 47.25 13.70 17 13551 936 32499022
Multiple organ dysfunction syndrome 44.19 13.70 93 13475 69761 32430197
Drug ineffective 43.08 13.70 290 13278 383187 32116771
Septum pellucidum agenesis 42.93 13.70 8 13560 25 32499933
Maternal drugs affecting foetus 42.79 13.70 25 13543 4252 32495706
Steroid withdrawal syndrome 41.35 13.70 11 13557 217 32499741
Foetal heart rate deceleration abnormality 40.91 13.70 13 13555 488 32499470
Hyponatraemia 37.95 13.70 91 13477 74422 32425536
Respiratory disorder neonatal 35.58 13.70 15 13553 1264 32498694
Hydrops foetalis 34.98 13.70 10 13558 260 32499698
Maternal exposure during pregnancy 34.68 13.70 22 13546 4335 32495623
Skin erosion 32.44 13.70 16 13552 1939 32498019
Polydipsia 32.21 13.70 20 13548 3797 32496161
Ventricular septal defect 29.98 13.70 19 13549 3738 32496220
Congenital hearing disorder 28.11 13.70 7 13561 105 32499853
Perioral dermatitis 27.87 13.70 7 13561 109 32499849
Bronchopulmonary dysplasia 27.58 13.70 10 13558 563 32499395
Congenital cystic lung 27.25 13.70 8 13560 229 32499729
Constipation 26.76 13.70 114 13454 126259 32373699
Polyhydramnios 26.58 13.70 8 13560 250 32499708
Persistent corneal epithelial defect 25.87 13.70 5 13563 20 32499938
Anaplastic astrocytoma 25.34 13.70 7 13561 160 32499798
Pneumonia 25.17 13.70 242 13326 355010 32144948
Corneal oedema 24.55 13.70 12 13556 1426 32498532
Ciliary hyperaemia 24.49 13.70 5 13563 28 32499930
Neonatal respiratory failure 24.00 13.70 8 13560 350 32499608
Cryptorchism 23.94 13.70 13 13555 1921 32498037
Ulcerative keratitis 23.80 13.70 12 13556 1524 32498434
Corneal opacity 23.73 13.70 9 13559 575 32499383
Drug abuse 23.28 13.70 3 13565 80240 32419718
Transient aphasia 22.67 13.70 6 13562 116 32499842
Abdominal pain 22.33 13.70 122 13446 149407 32350551
Sepsis 22.00 13.70 127 13441 158707 32341251
Neonatal cholestasis 21.68 13.70 5 13563 53 32499905
Skin indentation 21.59 13.70 4 13564 12 32499946
Enterocolitis bacterial 21.39 13.70 7 13561 289 32499669
Shared psychotic disorder 20.90 13.70 4 13564 15 32499943
Haemangioma congenital 20.86 13.70 8 13560 527 32499431
Epididymitis 20.82 13.70 13 13555 2491 32497467
Trisomy 21 20.81 13.70 8 13560 530 32499428
Tachycardia foetal 20.58 13.70 7 13561 326 32499632
Craniosynostosis 20.54 13.70 7 13561 328 32499630
Guttate psoriasis 20.10 13.70 6 13562 182 32499776
Ventricular fibrillation 19.96 13.70 30 13538 17280 32482678
Dermatitis acneiform 19.90 13.70 18 13550 6027 32493931
Congenital pulmonary valve atresia 19.90 13.70 5 13563 78 32499880
Large for dates baby 19.77 13.70 9 13559 912 32499046
Hypothalamic pituitary adrenal axis suppression 19.25 13.70 6 13562 211 32499747
Hypertrophic cardiomyopathy 19.08 13.70 9 13559 989 32498969
Fatigue 18.81 13.70 79 13489 350622 32149336
Corneal endotheliitis 18.35 13.70 4 13564 32 32499926
Premature delivery 17.99 13.70 5 13563 117 32499841
Asthenia 17.56 13.70 46 13522 235898 32264060
Glioblastoma 17.43 13.70 9 13559 1202 32498756
Eczema 17.32 13.70 26 13542 14954 32485004
Small for dates baby 17.24 13.70 13 13555 3380 32496578
Necrotising enterocolitis neonatal 17.24 13.70 5 13563 137 32499821
Adrenal insufficiency 17.13 13.70 23 13545 11945 32488013
Glucocorticoid deficiency 17.11 13.70 6 13562 306 32499652
Vertical infection transmission 17.05 13.70 3 13565 6 32499952
Selective eating disorder 16.98 13.70 10 13558 1726 32498232
Pyelocaliectasis 16.88 13.70 9 13559 1283 32498675
Scab 16.71 13.70 14 13554 4234 32495724
Vesicoureteric reflux 16.68 13.70 5 13563 154 32499804
Congenital pulmonary hypertension 16.67 13.70 4 13564 51 32499907
Cerebral ventricle dilatation 16.49 13.70 8 13560 935 32499023
Congenital herpes simplex infection 16.32 13.70 4 13564 56 32499902
Death neonatal 16.07 13.70 6 13562 367 32499591
Rickets 15.82 13.70 4 13564 64 32499894
Erythroblast count increased 15.52 13.70 3 13565 12 32499946
Microphthalmos 15.43 13.70 5 13563 200 32499758
Pneumocystis jirovecii pneumonia 15.41 13.70 28 13540 18842 32481116
Psoriatic arthropathy 15.22 13.70 27 13541 17833 32482125
General physical health deterioration 15.19 13.70 91 13477 115168 32384790
Acarodermatitis 15.01 13.70 6 13562 441 32499517
Congenital brain damage 14.98 13.70 3 13565 15 32499943
Laryngeal cleft 14.66 13.70 3 13565 17 32499941
Arthritis allergic 14.12 13.70 3 13565 21 32499937
Dyspnoea 14.08 13.70 91 13477 361954 32138004
Keratitis fungal 14.06 13.70 4 13564 102 32499856
Dermatitis atopic 13.77 13.70 10 13558 2457 32497501

Pharmacologic Action:

SourceCodeDescription
ATC A07EA04 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC C05AA05 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07XC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, potent, other combinations
ATC H02AB01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD06 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03BA04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
ATC S01BA06 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA07 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S03BA03 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC D07BC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, potent, combinations with antiseptics
ATC D07CC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
ATC S01BB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids and mydriatics in combination
ATC S01CA05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03CA06 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:65023 antiasthmatic agent
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D019141 Respiratory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Tinea pedis indication 6020002 DOID:12403
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Tinea corporis indication 84849002
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Tinea cruris indication 399029005
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Dermatosis of scalp indication 402694007 DOID:3136
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Erythroblastic Anemia indication
Diagnostic Test for Cushing's Syndrome indication
Systemic Dermatomyositis indication
Transfusion Reaction Urticaria indication
Synovitis due to Osteoarthritis indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Hypercalcemia associated with Sarcoidosis off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Congenital ichthyosis of skin contraindication 13059002
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Hypervitaminosis D contraindication 27712000 DOID:9971
Guttate psoriasis contraindication 37042000
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Hypercalcemia contraindication 66931009 DOID:12678
Psychotic disorder contraindication 69322001
Disorder of calcium metabolism contraindication 71638002 DOID:10575
Hypercalciuria contraindication 71938000
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Pustular psoriasis contraindication 200973000
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST IC50 8.07 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

IDSource
4018644 VUID
N0000146957 NUI
D00244 KEGG_DRUG
1514 RXNORM
C0005308 UMLSCUI
CHEBI:3077 CHEBI
CHEMBL632 ChEMBL_ID
D001623 MESH_DESCRIPTOR_UI
DB00443 DRUGBANK_ID
7061 IUPHAR_LIGAND_ID
1045 INN_ID
9842X06Q6M UNII
9782 PUBCHEM_CID
10006 MMSL
4270 MMSL
d00628 MMSL
002168 NDDF
116571008 SNOMEDCT_US
29896003 SNOMEDCT_US
4018644 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DR. THROWERS BETA HUMAN PRESCRIPTION DRUG LABEL 1 69299-202 OINTMENT 0.05 g TOPICAL unapproved drug other 4 sections