betamethasone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 348 378-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betamethasone
  • betadexamethasone
  • betametasone
  • betamethazone
  • bethamethasone
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.78
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P
0.40 mg P
0.40 mg N

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.07 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.38 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.36 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 17, 1961 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 1240.17 14.47 393 13187 23270 50568274
Premature baby 1020.36 14.47 319 13261 18018 50573526
Maternal exposure during pregnancy 726.98 14.47 479 13101 159299 50432245
Low birth weight baby 684.87 14.47 182 13398 5699 50585845
Exposure during pregnancy 619.17 14.47 391 13189 120624 50470920
Foetal exposure during pregnancy 585.29 14.47 234 13346 27125 50564419
Neonatal respiratory distress syndrome 220.25 14.47 63 13517 2591 50588953
Premature labour 203.67 14.47 86 13494 11390 50580154
Foetal growth restriction 167.25 14.47 64 13516 6563 50584981
Patent ductus arteriosus 145.48 14.47 50 13530 3770 50587774
Macular degeneration 136.85 14.47 70 13510 14318 50577226
Pre-eclampsia 115.70 14.47 52 13528 7992 50583552
Computerised tomogram thorax abnormal 111.03 14.47 32 13548 1351 50590193
Steroid withdrawal syndrome 104.54 14.47 25 13555 502 50591042
Caesarean section 101.26 14.47 59 13521 15580 50575964
Live birth 98.63 14.47 59 13521 16349 50575195
Psoriasis 92.54 14.47 103 13477 68897 50522647
Premature rupture of membranes 90.25 14.47 37 13543 4543 50587001
Respiratory disorder neonatal 85.58 14.47 24 13556 917 50590627
Ductus arteriosus premature closure 83.34 14.47 19 13561 307 50591237
Oligohydramnios 78.98 14.47 36 13544 5714 50585830
Gestational diabetes 78.84 14.47 39 13541 7426 50584118
Selective eating disorder 77.69 14.47 26 13554 1806 50589738
Preterm premature rupture of membranes 74.74 14.47 23 13557 1219 50590325
Bradycardia neonatal 65.36 14.47 19 13561 827 50590717
Normal newborn 64.90 14.47 33 13547 6658 50584886
Diabetes mellitus inadequate control 55.90 14.47 38 13542 13107 50578437
Atrial septal defect 54.97 14.47 29 13551 6312 50585232
Weight gain poor 53.87 14.47 16 13564 751 50590793
Atelectasis 53.16 14.47 42 13538 18228 50573316
Foetal hypokinesia 52.28 14.47 14 13566 449 50591095
Skin exfoliation 51.73 14.47 54 13526 33558 50557986
Product use in unapproved indication 49.29 14.47 101 13479 115718 50475826
Bronchopulmonary dysplasia 48.88 14.47 12 13568 270 50591274
Hydrops foetalis 46.47 14.47 12 13568 333 50591211
Placental insufficiency 45.80 14.47 16 13564 1265 50590279
Rectal cancer metastatic 45.17 14.47 11 13569 239 50591305
Computerised tomogram thorax 44.87 14.47 10 13570 145 50591399
Multiple drug therapy 42.82 14.47 17 13563 1920 50589624
Hypoxia 42.33 14.47 60 13520 51063 50540481
Neonatal gastrointestinal haemorrhage 42.24 14.47 7 13573 16 50591528
Cervical incompetence 39.86 14.47 12 13568 590 50590954
Amniotic cavity infection 39.57 14.47 14 13566 1149 50590395
Skin weeping 39.40 14.47 11 13569 413 50591131
Polyhydramnios 38.67 14.47 16 13564 2009 50589535
Foetal distress syndrome 38.64 14.47 14 13566 1231 50590313
Ophthalmic herpes simplex 36.17 14.47 10 13570 362 50591182
Acute pulmonary oedema 35.72 14.47 23 13557 7244 50584300
Infantile apnoea 35.47 14.47 12 13568 861 50590683
Blood pressure inadequately controlled 35.06 14.47 19 13561 4361 50587183
HELLP syndrome 34.87 14.47 12 13568 907 50590637
Starvation ketoacidosis 34.57 14.47 7 13573 62 50591482
Foetal heart rate deceleration abnormality 34.05 14.47 10 13570 451 50591093
Hypotonia neonatal 33.91 14.47 12 13568 985 50590559
Ventricular septal defect 33.66 14.47 18 13562 4023 50587521
Umbilical erythema 33.53 14.47 7 13573 73 50591471
Death 32.47 14.47 24 13556 325355 50266189
Foetal non-stress test abnormal 32.12 14.47 6 13574 33 50591511
Exercise tolerance decreased 30.51 14.47 18 13562 4856 50586688
Off label use 30.22 14.47 224 13356 474202 50117342
Neonatal hypocalcaemia 30.00 14.47 5 13575 12 50591532
Corneal perforation 29.32 14.47 9 13571 473 50591071
Arthropathy 28.99 14.47 4 13576 157902 50433642
Neonatal respiratory failure 27.29 14.47 7 13573 189 50591355
Pneumocystis jirovecii pneumonia 27.05 14.47 26 13554 14637 50576907
Drug intolerance 26.26 14.47 13 13567 219091 50372453
Right ventricular dysfunction 25.32 14.47 11 13569 1557 50589987
Cholestasis of pregnancy 25.26 14.47 10 13570 1121 50590423
Pain 25.25 14.47 76 13504 578827 50012717
Meningitis chemical 24.70 14.47 6 13574 129 50591415
Pulmonary hypoplasia 24.57 14.47 7 13573 283 50591261
Asthenia 24.27 14.47 30 13550 319012 50272532
Cerebral haemorrhage neonatal 24.23 14.47 6 13574 140 50591404
Pneumocephalus 24.23 14.47 6 13574 140 50591404
Pulmonary valve stenosis congenital 23.95 14.47 6 13574 147 50591397
Perioral dermatitis 23.80 14.47 6 13574 151 50591393
Intraventricular haemorrhage neonatal 23.61 14.47 6 13574 156 50591388
Joint swelling 23.30 14.47 19 13561 245267 50346277
Skin infection 23.06 14.47 22 13558 12269 50579275
Maternal condition affecting foetus 22.92 14.47 6 13574 176 50591368
Systemic lupus erythematosus 22.67 14.47 5 13575 140617 50450927
Gastrointestinal disorder 22.57 14.47 66 13514 94390 50497154
Toxic anterior segment syndrome 22.13 14.47 10 13570 1555 50589989
Small for dates baby 22.09 14.47 13 13567 3492 50588052
Breech presentation 21.94 14.47 9 13571 1105 50590439
Gestational hypertension 21.90 14.47 11 13569 2162 50589382
Pulmonary valve disease 21.73 14.47 4 13576 20 50591524
Meconium abnormal 21.67 14.47 3 13577 0 50591544
Death neonatal 21.47 14.47 6 13574 226 50591318
Foetal growth abnormality 21.26 14.47 4 13576 23 50591521
Neonatal intestinal perforation 21.12 14.47 4 13576 24 50591520
Serratia infection 21.07 14.47 8 13572 802 50590742
Glossodynia 21.04 14.47 3 13577 115566 50475978
Libido increased 20.99 14.47 9 13571 1234 50590310
Aplastic anaemia 20.90 14.47 17 13563 7686 50583858
Skin burning sensation 20.58 14.47 19 13561 10166 50581378
Oesophageal atresia 20.46 14.47 7 13573 520 50591024
Tracheo-oesophageal fistula 20.37 14.47 7 13573 527 50591017
Fall 20.14 14.47 37 13543 334895 50256649
Rheumatoid arthritis 20.10 14.47 15 13565 202535 50389009
Therapeutic product effect decreased 19.71 14.47 6 13574 136044 50455500
Angiotensin converting enzyme inhibitor foetopathy 19.69 14.47 4 13576 36 50591508
Delayed delivery 19.60 14.47 4 13576 37 50591507
Soft tissue injury 19.46 14.47 9 13571 1475 50590069
Anaemia neonatal 19.37 14.47 6 13574 325 50591219
Ultrasound uterus abnormal 19.31 14.47 4 13576 40 50591504
Discomfort 19.29 14.47 3 13577 108377 50483167
Retroplacental haematoma 19.05 14.47 5 13575 148 50591396
Infusion related reaction 18.93 14.47 11 13569 169546 50421998
Arthralgia 18.80 14.47 58 13522 438644 50152900
Synovitis 18.80 14.47 5 13575 123860 50467684
Wound 18.67 14.47 3 13577 105791 50485753
Ulcerative keratitis 18.34 14.47 10 13570 2323 50589221
Hostility 17.90 14.47 9 13571 1773 50589771
Sepsis neonatal 17.82 14.47 6 13574 424 50591120
Respiratory failure 17.44 14.47 59 13521 91122 50500422
Human herpesvirus 6 infection 17.31 14.47 10 13570 2596 50588948
Post-traumatic neck syndrome 17.31 14.47 9 13571 1901 50589643
Dry gangrene 17.07 14.47 6 13574 483 50591061
Adrenal haematoma 17.05 14.47 3 13577 11 50591533
Confusional state 16.91 14.47 15 13565 185913 50405631
Sternal fracture 16.91 14.47 9 13571 1993 50589551
Scab 16.79 14.47 14 13566 6548 50584996
Right aortic arch 16.74 14.47 5 13575 239 50591305
Cyanosis neonatal 16.17 14.47 5 13575 269 50591275
Umbilical cord prolapse 15.98 14.47 3 13577 17 50591527
Shared psychotic disorder 15.70 14.47 3 13577 19 50591525
White matter lesion 15.64 14.47 8 13572 1634 50589910
Palmoplantar keratoderma 15.56 14.47 4 13576 109 50591435
Corneal neovascularisation 15.52 14.47 4 13576 110 50591434
Adenovirus infection 15.50 14.47 10 13570 3158 50588386
Twin pregnancy 15.38 14.47 7 13573 1106 50590438
Contusion 15.18 14.47 65 13515 112118 50479426
Toxicity to various agents 15.09 14.47 21 13559 212478 50379066
Impetigo 15.06 14.47 7 13573 1160 50590384
Decreased insulin requirement 14.74 14.47 4 13576 135 50591409
Pulmonary haemorrhage neonatal 14.58 14.47 3 13577 29 50591515
Ultrasound Doppler abnormal 14.52 14.47 4 13576 143 50591401

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 847.05 18.95 280 8574 17000 29548673
Low birth weight baby 506.83 18.95 151 8703 6457 29559216
Foetal exposure during pregnancy 504.03 18.95 231 8623 33636 29532037
Drug eruption 342.29 18.95 143 8711 16598 29549075
Appendicolith 255.69 18.95 77 8777 3403 29562270
Hepatic function abnormal 244.82 18.95 150 8704 39109 29526564
Urticaria 231.59 18.95 164 8690 54496 29511177
Stomatitis 229.33 18.95 141 8713 36972 29528701
Hypersensitivity 210.92 18.95 153 8701 52750 29512923
Appendicitis 192.81 18.95 79 8775 8700 29556973
Epistaxis 182.45 18.95 139 8715 51565 29514108
Muscle spasms 174.56 18.95 149 8705 64933 29500740
Pain in extremity 135.93 18.95 166 8688 110267 29455406
Cardiogenic shock 134.12 18.95 79 8775 19111 29546562
Stress 133.46 18.95 82 8772 21408 29544265
Patent ductus arteriosus 126.39 18.95 44 8810 3087 29562586
Atrial septal defect 105.93 18.95 48 8806 6741 29558932
Ascites 96.28 18.95 83 8771 36536 29529137
Neonatal respiratory distress syndrome 92.95 18.95 37 8817 3773 29561900
Abdominal distension 80.27 18.95 83 8771 45828 29519845
Hyponatraemia 72.42 18.95 95 8759 67538 29498135
Drug ineffective 72.33 18.95 255 8599 362915 29202758
Multiple organ dysfunction syndrome 69.66 18.95 90 8764 63026 29502647
Foetal growth restriction 63.11 18.95 28 8826 3738 29561935
Foetal heart rate deceleration abnormality 45.48 18.95 13 8841 476 29565197
Psoriasis 45.34 18.95 52 8802 32175 29533498
Constipation 41.79 18.95 100 8754 114060 29451613
Ventricular fibrillation 41.78 18.95 36 8818 15797 29549876
Sepsis 40.91 18.95 114 8740 142568 29423105
Toxicity to various agents 40.57 18.95 3 8851 173658 29392015
Polydipsia 40.24 18.95 20 8834 3445 29562228
Steroid withdrawal syndrome 39.99 18.95 10 8844 217 29565456
Hydrops foetalis 39.44 18.95 10 8844 230 29565443
Septum pellucidum agenesis 39.25 18.95 8 8846 65 29565608
Abdominal pain 37.67 18.95 107 8747 135250 29430423
Respiratory disorder neonatal 35.31 18.95 14 8840 1411 29564262
General physical health deterioration 34.33 18.95 87 8767 102770 29462903
Maternal exposure during pregnancy 34.20 18.95 19 8835 4104 29561569
Death 33.47 18.95 32 8822 342052 29223621
Congenital hearing disorder 31.08 18.95 7 8847 95 29565578
Pneumonia 30.98 18.95 182 8672 319990 29245683
Congenital cystic lung 30.11 18.95 8 8846 222 29565451
Perioral dermatitis 29.83 18.95 7 8847 115 29565558
Cryptorchism 27.99 18.95 13 8841 1929 29563744
Neonatal respiratory failure 26.86 18.95 8 8846 339 29565334
Ventricular septal defect 25.86 18.95 15 8839 3514 29562159
Transient aphasia 25.83 18.95 6 8848 94 29565579
Ciliary hyperaemia 25.71 18.95 5 8849 31 29565642
Persistent corneal epithelial defect 25.44 18.95 5 8849 33 29565640
Polyhydramnios 25.01 18.95 7 8847 237 29565436
Anaplastic astrocytoma 24.80 18.95 6 8848 113 29565560
Haemangioma congenital 24.00 18.95 8 8846 491 29565182
Trisomy 21 23.87 18.95 8 8846 499 29565174
Vertical infection transmission 23.75 18.95 4 8850 9 29565664
Hypothalamic pituitary adrenal axis suppression 23.66 18.95 6 8848 138 29565535
Craniosynostosis 23.29 18.95 7 8847 306 29565367
Congenital pulmonary valve atresia 23.16 18.95 5 8849 55 29565618
Large for dates baby 22.98 18.95 9 8845 878 29564795
Skin indentation 22.92 18.95 4 8850 12 29565661
Shared psychotic disorder 22.23 18.95 4 8850 15 29565658
Glioblastoma 22.15 18.95 9 8845 967 29564706
Pyelocaliectasis 21.04 18.95 9 8845 1100 29564573
Glucocorticoid deficiency 20.41 18.95 6 8848 243 29565430
Premature delivery 20.33 18.95 5 8849 101 29565572
Cerebral ventricle dilatation 19.84 18.95 8 8846 842 29564831
Bronchopulmonary dysplasia 19.75 18.95 7 8847 517 29565156
Tachycardia foetal 19.69 18.95 6 8848 275 29565398
Hypertrophic cardiomyopathy 19.58 18.95 8 8846 871 29564802
Congenital herpes simplex infection 19.16 18.95 4 8850 37 29565636

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 1100.92 13.75 342 17548 18247 64462595
Maternal exposure during pregnancy 717.55 13.75 401 17489 95483 64385359
Exposure during pregnancy 586.56 13.75 327 17563 77348 64403494
Drug eruption 277.34 13.75 154 17736 35982 64444860
Appendicolith 261.56 13.75 77 17813 3392 64477450
Hepatic function abnormal 216.05 13.75 163 17727 64150 64416692
Premature labour 209.34 13.75 79 17811 7541 64473301
Urticaria 165.63 13.75 204 17686 147113 64333729
Appendicitis 165.40 13.75 79 17811 13490 64467352
Epistaxis 135.37 13.75 151 17739 97980 64382862
Psoriasis 117.66 13.75 121 17769 71582 64409260
Steroid withdrawal syndrome 113.47 13.75 28 17862 622 64480220
Stomatitis 112.30 13.75 145 17745 109460 64371382
Pre-eclampsia 106.73 13.75 46 17844 6185 64474657
Caesarean section 105.90 13.75 55 17835 11219 64469623
Muscle spasms 104.91 13.75 160 17730 140863 64339979
Live birth 103.36 13.75 54 17836 11150 64469692
Computerised tomogram thorax abnormal 98.83 13.75 32 17858 1937 64478905
Cardiogenic shock 97.46 13.75 77 17813 32350 64448492
Hypersensitivity 91.23 13.75 181 17709 196271 64284571
Premature baby 82.94 13.75 32 17858 3240 64477602
Premature rupture of membranes 82.21 13.75 33 17857 3711 64477131
Ascites 79.64 13.75 92 17798 61909 64418933
Gestational diabetes 78.80 13.75 36 17854 5554 64475288
Stress 78.05 13.75 90 17800 60444 64420398
Preterm premature rupture of membranes 71.68 13.75 22 17868 1117 64479725
Normal newborn 66.30 13.75 32 17858 5585 64475257
Drug ineffective 62.02 13.75 421 17469 839826 63641016
Abdominal distension 59.11 13.75 100 17790 95894 64384948
Skin exfoliation 58.29 13.75 67 17823 44818 64436024
Multiple organ dysfunction syndrome 55.11 13.75 100 17790 101313 64379529
Pain in extremity 54.33 13.75 196 17694 302889 64177953
Perioral dermatitis 53.97 13.75 13 17877 260 64480582
Skin weeping 52.11 13.75 15 17875 609 64480233
Oligohydramnios 50.03 13.75 22 17868 3102 64477740
Foetal growth restriction 47.73 13.75 18 17872 1712 64479130
Corneal endotheliitis 46.53 13.75 9 17881 59 64480783
Toxicity to various agents 45.51 13.75 22 17868 363491 64117351
Death 44.61 13.75 41 17849 482664 63998178
Computerised tomogram thorax 44.48 13.75 10 17880 146 64480696
Ophthalmic herpes simplex 44.17 13.75 13 17877 571 64480271
Off label use 42.94 13.75 311 17579 632495 63848347
Atelectasis 42.86 13.75 45 17845 27221 64453621
Product use in unapproved indication 42.19 13.75 126 17764 176492 64304350
Placental insufficiency 40.91 13.75 14 17876 1006 64479836
Ulcerative keratitis 40.70 13.75 19 17871 3078 64477764
Pneumocystis jirovecii pneumonia 40.59 13.75 44 17846 27590 64453252
Amniotic cavity infection 40.57 13.75 13 17877 761 64480081
Polyhydramnios 39.32 13.75 15 17875 1472 64479370
Rectal cancer metastatic 38.42 13.75 11 17879 438 64480404
HELLP syndrome 37.70 13.75 12 17878 687 64480155
Shared psychotic disorder 37.02 13.75 7 17883 40 64480802
Diabetes mellitus inadequate control 36.79 13.75 37 17853 21284 64459558
Multiple drug therapy 36.51 13.75 16 17874 2238 64478604
Ventricular fibrillation 35.06 13.75 38 17852 23822 64457020
Polydipsia 34.50 13.75 21 17869 5800 64475042
Corneal perforation 33.85 13.75 11 17879 673 64480169
Hypothalamic pituitary adrenal axis suppression 33.42 13.75 9 17881 285 64480557
Hyponatraemia 32.77 13.75 103 17787 148236 64332606
Cervical incompetence 32.69 13.75 10 17880 502 64480340
Pulmonary valve stenosis congenital 32.49 13.75 5 17885 5 64480837
Sepsis 32.32 13.75 138 17752 230203 64250639
Cerebral haemorrhage neonatal 32.01 13.75 5 17885 6 64480836
Foetal exposure during pregnancy 31.38 13.75 18 17872 4458 64476384
Asthenia 31.21 13.75 44 17846 428000 64052842
Starvation ketoacidosis 30.53 13.75 7 17883 112 64480730
Blood pressure inadequately controlled 28.31 13.75 18 17872 5366 64475476
Cholestasis of pregnancy 26.89 13.75 10 17880 915 64479927
Constipation 26.65 13.75 130 17760 229207 64251635
Scab 26.18 13.75 21 17869 9001 64471841
Gastrointestinal disorder 25.30 13.75 68 17822 89641 64391201
Skin burning sensation 25.26 13.75 22 17868 10561 64470281
Gestational hypertension 24.24 13.75 11 17879 1670 64479172
Persistent corneal epithelial defect 24.16 13.75 5 17885 48 64480794
Maternal condition affecting foetus 24.11 13.75 6 17884 138 64480704
Drug abuse 23.88 13.75 4 17886 132370 64348472
Anaplastic astrocytoma 23.83 13.75 6 17884 145 64480697
Acute pulmonary oedema 23.52 13.75 23 17867 12786 64468056
Foetal hypokinesia 23.47 13.75 7 17883 322 64480520
Transient aphasia 23.02 13.75 6 17884 167 64480675
Ciliary hyperaemia 22.78 13.75 5 17885 65 64480777
Exercise tolerance decreased 22.49 13.75 18 17872 7692 64473150
Meningitis chemical 21.98 13.75 6 17884 200 64480642
Atrial septal defect 21.29 13.75 10 17880 1643 64479199
Foetal distress syndrome 21.28 13.75 7 17883 445 64480397
Delayed delivery 21.13 13.75 4 17886 23 64480819
Pneumocephalus 20.95 13.75 6 17884 239 64480603
Patent ductus arteriosus 20.76 13.75 5 17885 100 64480742
Fall 20.61 13.75 54 17836 416772 64064070
Skin infection 20.45 13.75 23 17867 15014 64465828
Retroplacental haematoma 20.09 13.75 5 17885 115 64480727
Glucocorticoid deficiency 19.86 13.75 7 17883 549 64480293
Low birth weight baby 19.84 13.75 7 17883 551 64480291
Glioblastoma 19.31 13.75 9 17881 1452 64479390
Hypoxia 19.26 13.75 61 17829 88088 64392754
Joint swelling 19.02 13.75 19 17871 215363 64265479
Soft tissue injury 18.65 13.75 9 17881 1570 64479272
Drug intolerance 18.49 13.75 15 17875 187977 64292865
Acute kidney injury 18.07 13.75 64 17826 449176 64031666
Anaemia 18.01 13.75 50 17840 378630 64102212
Arthralgia 17.79 13.75 63 17827 442197 64038645
Cardiac failure congestive 17.74 13.75 7 17883 130573 64350269
Pharyngeal erythema 17.72 13.75 9 17881 1750 64479092
General physical health deterioration 17.72 13.75 107 17783 204318 64276524
Toxic anterior segment syndrome 17.61 13.75 10 17880 2429 64478413
Libido increased 17.58 13.75 9 17881 1781 64479061
Haemoglobin decreased 17.46 13.75 17 17873 195046 64285796
Adrenal insufficiency 17.37 13.75 26 17864 22461 64458381
Arthropathy 17.25 13.75 6 17884 120961 64359881
Ventricular septal defect 17.12 13.75 6 17884 463 64480379
Post-traumatic neck syndrome 17.06 13.75 9 17881 1893 64478949
Twin pregnancy 17.00 13.75 7 17883 840 64480002
Umbilical cord prolapse 16.95 13.75 3 17887 11 64480831
Familial mediterranean fever 16.65 13.75 4 17886 79 64480763
Abdominal pain 16.40 13.75 145 17745 312230 64168612
Rheumatoid arthritis 16.29 13.75 13 17877 164281 64316561
Foetal heart rate deceleration abnormality 16.20 13.75 4 17886 89 64480753
Dehydration 16.05 13.75 22 17868 216741 64264101
Serratia infection 16.00 13.75 8 17882 1505 64479337
Arthritis allergic 15.89 13.75 3 17887 17 64480825
Hostility 15.81 13.75 9 17881 2198 64478644
Synovitis 15.79 13.75 4 17886 99086 64381756
Dermatitis atopic 15.66 13.75 11 17879 3865 64476977
Sternal fracture 15.66 13.75 9 17881 2238 64478604
Hypotension 15.49 13.75 54 17836 380920 64099922
Corneal oedema 15.31 13.75 9 17881 2334 64478508
Pain 15.04 13.75 91 17799 553420 63927422
Hypertension 15.01 13.75 123 17767 259138 64221704
Impetigo 14.67 13.75 8 17882 1798 64479044
Endophthalmitis 14.54 13.75 12 17878 5353 64475489
Corneal neovascularisation 14.28 13.75 4 17886 147 64480695
Decreased insulin requirement 14.28 13.75 4 17886 147 64480695
Contusion 14.23 13.75 66 17824 113899 64366943
Nausea 13.99 13.75 300 17590 785500 63695342
Palmoplantar keratoderma 13.85 13.75 5 17885 421 64480421

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EA04 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC C05AA05 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07BC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, potent, combinations with antiseptics
ATC D07CC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
ATC D07XC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, potent, other combinations
ATC H02AB01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD06 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03BA04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
ATC S01BA06 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01BB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids and mydriatics in combination
ATC S01CA05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S01CB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA07 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S03BA03 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC S03CA06 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:65023 anti-asthmatic agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D019141 Respiratory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Tinea pedis indication 6020002 DOID:12403
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Lรถffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Tinea corporis indication 84849002
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Tinea cruris indication 399029005
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Dermatosis of scalp indication 402694007 DOID:3136
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Diagnostic Test for Cushing's Syndrome indication
Systemic Dermatomyositis indication
Synovitis due to Osteoarthritis indication
Erythroblastic Anemia indication
Transfusion Reaction Urticaria indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Neonatal Bronchopulmonary Dysplasia off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Congenital ichthyosis of skin contraindication 13059002
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Hypervitaminosis D contraindication 27712000 DOID:9971
Guttate psoriasis contraindication 37042000
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Hypercalcemia contraindication 66931009 DOID:12678
Psychotic disorder contraindication 69322001
Disorder of calcium metabolism contraindication 71638002 DOID:10575
Hypercalciuria contraindication 71938000
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Pustular psoriasis contraindication 200973000
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST IC50 8.07 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

IDSource
4018644 VUID
N0000146957 NUI
D00244 KEGG_DRUG
1514 RXNORM
C0005308 UMLSCUI
CHEBI:3077 CHEBI
CHEMBL632 ChEMBL_ID
D001623 MESH_DESCRIPTOR_UI
DB00443 DRUGBANK_ID
7061 IUPHAR_LIGAND_ID
1045 INN_ID
9842X06Q6M UNII
9782 PUBCHEM_CID
10006 MMSL
4270 MMSL
d00628 MMSL
002168 NDDF
4018644 VANDF
116571008 SNOMEDCT_US
29896003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DR. THROWERS BETA HUMAN PRESCRIPTION DRUG LABEL 1 69299-202 OINTMENT 0.05 g TOPICAL unapproved drug other 4 sections