Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	348	378-44-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: betamethasone betadexamethasone betametasone betamethazone bethamethasone	A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724) Molecular weight: 392.47 Formula: C22H29FO5 CLOGP: 1.78 LIPINSKI: 0 HAC: 5 HDO: 3 TPSA: 94.83 ALOGS: -3.89 ROTB: 2 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

betamethasone
betadexamethasone
betametasone
betamethazone
bethamethasone

A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)

Molecular weight: 392.47
Formula: C22H29FO5
CLOGP: 1.78
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 94.83
ALOGS: -3.89
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1.50	mg	O
1.50	mg	P
0.40	mg	P
0.40	mg	N

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.06 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	4.80 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.38 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	1.30 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.36 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	5.60 hours	Lombardo F, Berellini G, Obach RS
BA (Bioavailability)	0.72 %	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	1.976		Moderate	0.65
caco2-efflux	Caco-2 efflux ratio (BA/AB)	5.152		Moderate	0.65
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	27.416	10^-6 cm/s	Moderate	0.65
dh-clint	Dog hepatocyte intrinsic clearance	4.416	uL/min/10^6 cells	Moderate	0.65
dppb	Dog plasma protein binding (% unbound)	42.180	%	Moderate	0.65
fcs-ppb	Fetal calf serum protein binding (% unbound)	53.280	%	Moderate	0.65
herg	hERG pIC50	4.353	pIC50	Moderate	0.65
hh-clint	Human hepatocyte intrinsic clearance	2.056	uL/min/10^6 cells	Moderate	0.65
hlm-clint	Human liver microsomal intrinsic clearance	10.568	uL/min/mg protein	Moderate	0.65
hppb	Human plasma protein binding (% unbound)	29.420	%	Moderate	0.65
kinase-safety-class	ACVR2B,CDK5,EIF2AK3,GRK2,ITK,MAPK10,PDK1,PDK2,PDK4,PRKDC	10
kinase-selectivity-class	GRK2,MAP2K6	2
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	15.276		High	1
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	11.220		Moderate	0.65
mh-clint	Mouse hepatocyte intrinsic clearance	8.472		Moderate	0.65
mppb	Mouse plasma protein binding (% unbound)	38.410		Moderate	0.65
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	18.578		Moderate	0.65
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	0		High	1
pppb	Pig plasma protein binding (% unbound)	40.890	%	Moderate	0.65
rat-kpuu-brain	Rat brain Kpuu	0.067	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	15.959	uL/min/10^6 cells	Moderate	0.65
rh-fuinc	Rat hepatocyte fraction unbound in incubation	74.520	%	Moderate	0.65
rppb	Rat plasma protein binding (% unbound)	26.010	%	Moderate	0.65
solubility-dd	Solubility at pH 7.4 in DMSO	422.669	uM	Moderate	0.65

Approvals:

Date	Agency	Company	Orphan
April 17, 1961	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature delivery	1729.05	12.46	660	42154	38102	90547531
Premature baby	1063.90	12.46	412	42402	24665	90560968
Maternal exposure during pregnancy	903.39	12.46	974	41840	359089	90226544
Low birth weight baby	669.49	12.46	227	42587	9240	90576393
Foetal exposure during pregnancy	589.32	12.46	322	42492	42653	90542980
Exposure during pregnancy	487.43	12.46	581	42233	237829	90347804
Normal labour	292.22	12.46	66	42748	551	90585082
Macular degeneration	271.99	12.46	188	42626	37782	90547851
Delivery	257.70	12.46	74	42740	1719	90583914
Neonatal respiratory distress syndrome	233.58	12.46	78	42736	3023	90582610
Product use in unapproved indication	211.99	12.46	481	42333	335755	90249878
Infusion site reaction	207.87	12.46	123	42691	18916	90566717
Foetal growth restriction	206.88	12.46	97	42717	9283	90576350
Blepharospasm	168.79	12.46	167	42647	55278	90530355
Premature labour	163.49	12.46	93	42721	13283	90572350
Computerised tomogram thorax abnormal	151.26	12.46	51	42763	2036	90583597
Live birth	150.13	12.46	186	42628	78921	90506712
Back injury	142.97	12.46	141	42673	46481	90539152
Pre-eclampsia	132.84	12.46	76	42738	10972	90574661
Patent ductus arteriosus	122.05	12.46	54	42760	4515	90581118
Epilepsy	115.63	12.46	167	42647	82039	90503594
Computerised tomogram thorax	104.60	12.46	28	42786	497	90585136
Taste disorder	103.03	12.46	136	42678	61410	90524223
Steroid withdrawal syndrome	93.14	12.46	27	42787	649	90584984
Breast cancer stage III	92.71	12.46	153	42661	84294	90501339
Normal newborn	91.55	12.46	81	42733	23281	90562352
Hypercholesterolaemia	85.24	12.46	163	42651	100729	90484904
Fall	84.01	12.46	63	42751	481747	90103886
Blood pressure inadequately controlled	83.47	12.46	46	42768	6178	90579455
Therapeutic product effect incomplete	83.03	12.46	240	42574	193656	90391977
Premature rupture of membranes	79.87	12.46	43	42771	5515	90580118
Onychomadesis	79.08	12.46	103	42711	45895	90539738
Fatigue	78.10	12.46	282	42532	1153741	89431892
Exercise tolerance decreased	77.77	12.46	47	42767	7504	90578129
Skin exfoliation	77.18	12.46	125	42689	67788	90517845
Diabetes mellitus inadequate control	69.68	12.46	63	42751	18621	90567012
Ductus arteriosus premature closure	67.70	12.46	19	42795	405	90585228
Peripheral venous disease	66.52	12.46	132	42682	83789	90501844
Preterm premature rupture of membranes	66.11	12.46	26	42788	1615	90584018
Atelectasis	66.02	12.46	69	42745	24340	90561293
Gastrooesophageal reflux disease	63.73	12.46	198	42616	166139	90419494
Foetal heart rate deceleration abnormality	62.98	12.46	20	42794	659	90584974
Respiratory disorder neonatal	62.85	12.46	24	42790	1377	90584256
Overlap syndrome	62.77	12.46	43	42771	8505	90577128
Caesarean section	62.23	12.46	59	42755	18518	90567115
Product quality issue	61.94	12.46	124	42690	79201	90506432
Death	61.69	12.46	75	42739	456476	90129157
Drug ineffective	60.89	12.46	953	41861	1383345	89202288
Selective eating disorder	60.48	12.46	26	42788	2027	90583606
Psoriasis	59.51	12.46	179	42635	147575	90438058
Gestational diabetes	58.90	12.46	45	42769	10537	90575096
Multiple drug therapy	58.06	12.46	38	42776	6971	90578662
Facet joint syndrome	57.67	12.46	137	42677	98252	90487381
Liver function test increased	56.20	12.46	124	42690	84731	90500902
Diarrhoea	56.08	12.46	241	42573	938949	89646684
Oligohydramnios	54.72	12.46	37	42777	7164	90578469
Chronic sinusitis	51.74	12.46	60	42754	23742	90561891
Neutropenia	51.29	12.46	21	42793	224883	90360750
Bradycardia neonatal	50.02	12.46	19	42795	1074	90584559
Neonatal hypocalcaemia	48.52	12.46	9	42805	23	90585610
Atrial septal defect	48.01	12.46	36	42778	8198	90577435
Acute kidney injury	47.22	12.46	49	42765	320338	90265295
Toxicity to various agents	47.14	12.46	40	42774	287806	90297827
Analgesic therapy	47.04	12.46	16	42798	656	90584977
Pain	46.21	12.46	279	42535	996062	89589571
Antacid therapy	45.24	12.46	16	42798	738	90584895
Appendicolith	45.09	12.46	16	42798	745	90584888
Foetal hypokinesia	44.17	12.46	15	42799	612	90585021
Drug therapy	44.14	12.46	16	42798	793	90584840
Anticoagulant therapy	43.98	12.46	16	42798	801	90584832
Neonatal gastrointestinal haemorrhage	43.25	12.46	8	42806	20	90585613
Vomiting	41.27	12.46	212	42602	788081	89797552
Seizure	40.47	12.46	11	42803	152618	90433015
Urinary tract infection	40.41	12.46	51	42763	305581	90280052
Bronchopulmonary dysplasia	40.35	12.46	14	42800	610	90585023
Infantile apnoea	40.24	12.46	17	42797	1270	90584363
Wound infection	40.12	12.46	126	42688	106276	90479357
Paraesthesia oral	39.73	12.46	61	42753	31598	90554035
Neonatal gastrointestinal disorder	39.24	12.46	9	42805	81	90585552
Weight gain poor	38.38	12.46	16	42798	1156	90584477
Medication error	38.35	12.46	107	42707	84545	90501088
Bursitis	38.33	12.46	143	42671	131511	90454122
Rectal cancer metastatic	37.38	12.46	11	42803	279	90585354
Hypotension	37.38	12.46	60	42754	325337	90260296
Neonatal respiratory depression	36.92	12.46	10	42804	186	90585447
Incorrect route of product administration	35.82	12.46	76	42738	50550	90535083
Foetal distress syndrome	35.65	12.46	17	42797	1688	90583945
Hypoxia	35.28	12.46	94	42720	72305	90513328
Neck pain	35.04	12.46	126	42688	113837	90471796
Polyhydramnios	34.91	12.46	19	42795	2489	90583144
Dry mouth	34.44	12.46	175	42639	183884	90401749
Foetal non-stress test abnormal	34.42	12.46	7	42807	33	90585600
Bone erosion	33.43	12.46	76	42738	52945	90532688
Nail disorder	33.26	12.46	81	42733	58986	90526647
Sepsis neonatal	32.98	12.46	12	42802	601	90585032
White blood cell count decreased	32.93	12.46	19	42795	167090	90418543
Placental insufficiency	32.90	12.46	16	42798	1659	90583974
Multiple epiphyseal dysplasia	32.57	12.46	8	42806	99	90585534
Amniotic cavity infection	32.53	12.46	15	42799	1381	90584252
Cervical incompetence	32.33	12.46	12	42802	636	90584997
Breast cancer stage II	32.21	12.46	59	42755	35275	90550358
Night sweats	31.93	12.46	133	42681	128633	90457000
Obesity	31.88	12.46	116	42698	105391	90480242
Skeletal dysplasia	31.86	12.46	8	42806	109	90585524
Neonatal cholestasis	31.71	12.46	7	42807	52	90585581
Cardiac failure congestive	30.48	12.46	5	42809	98689	90486944
Catarrh	30.28	12.46	15	42799	1619	90584014
C-reactive protein increased	30.20	12.46	167	42647	181222	90404411
Umbilical erythema	29.59	12.46	7	42807	73	90585560
Procedural pain	29.52	12.46	55	42759	33305	90552328
Decreased appetite	29.48	12.46	86	42728	376454	90209179
Dehydration	29.47	12.46	29	42785	194418	90391215
Hypersensitivity	29.34	12.46	113	42701	454564	90131069
Hydrops foetalis	29.30	12.46	11	42803	602	90585031
Hypotonia neonatal	29.12	12.46	14	42800	1416	90584217
Drug interaction	28.98	12.46	54	42760	276399	90309234
Infection	28.86	12.46	82	42732	362012	90223621
Ophthalmic herpes simplex	28.79	12.46	11	42803	632	90585001
Psoriatic arthropathy	28.42	12.46	195	42619	228140	90357493
Drug abuse	28.23	12.46	3	42811	82344	90503289
HELLP syndrome	28.12	12.46	13	42801	1204	90584429
Radiculopathy	28.07	12.46	39	42775	18466	90567167
Neonatal respiratory failure	27.93	12.46	9	42805	311	90585322
Frequent bowel movements	27.82	12.46	74	42740	56861	90528772
Skin weeping	27.74	12.46	17	42797	2783	90582850
Hepatic cirrhosis	27.71	12.46	79	42735	63174	90522459
Female genital tract fistula	27.62	12.46	38	42776	17830	90567803
Burns second degree	27.56	12.46	15	42799	1965	90583668
Gait inability	26.52	12.46	138	42676	146318	90439315
Foetal exposure during delivery	26.41	12.46	9	42805	371	90585262
Brachydactyly	26.30	12.46	8	42806	228	90585405
Vaginal flatulence	26.04	12.46	31	42783	12607	90573026
Hyperphosphataemia	25.68	12.46	18	42796	3693	90581940
Steroid dependence	25.65	12.46	15	42799	2254	90583379
Foetal anaemia	25.60	12.46	7	42807	135	90585498
Ulcer haemorrhage	25.33	12.46	45	42769	26276	90559357
Social (pragmatic) communication disorder	24.69	12.46	5	42809	23	90585610
Sensory processing disorder	24.51	12.46	5	42809	24	90585609
Lung disorder	24.28	12.46	137	42677	149746	90435887
Neonatal intestinal perforation	24.18	12.46	5	42809	26	90585607
Papule	24.14	12.46	24	42790	7978	90577655
Product dose omission issue	24.02	12.46	65	42749	291622	90294011
Coma	24.01	12.46	3	42811	72629	90513004
Foetal heart rate disorder	24.00	12.46	7	42807	172	90585461
Back pain	23.70	12.46	74	42740	317101	90268532
Cardiac arrest	23.58	12.46	10	42804	104925	90480708
Discomfort	23.45	12.46	60	42754	274275	90311358
Skin infection	23.23	12.46	35	42779	17829	90567804
Joint swelling	23.20	12.46	141	42673	503159	90082474
Blood uric acid increased	23.05	12.46	23	42791	7681	90577952
Proctitis	22.91	12.46	32	42782	15227	90570406
Laryngitis	22.83	12.46	64	42750	50689	90534944
Starvation ketoacidosis	22.42	12.46	7	42807	218	90585415
Myocardial infarction	22.41	12.46	11	42803	105961	90479672
Maternal condition affecting foetus	22.24	12.46	7	42807	224	90585409
Corneal perforation	22.22	12.46	9	42805	604	90585029
Polyglandular disorder	22.15	12.46	7	42807	227	90585406
Heart rate increased	22.00	12.46	13	42801	112889	90472744
Exostosis	21.97	12.46	65	42749	53069	90532564
Depressed level of consciousness	21.79	12.46	4	42810	72780	90512853
White matter lesion	21.69	12.46	14	42800	2507	90583126
Ventricular septal defect	21.68	12.46	19	42795	5388	90580245
Renal failure	21.68	12.46	18	42796	130989	90454644
Intentional overdose	20.99	12.46	9	42805	93825	90491808
Vaginal discharge	20.99	12.46	35	42779	19429	90566204
Rectal haemorrhage	20.93	12.46	86	42728	82658	90502975
Cerebral haemorrhage neonatal	20.86	12.46	6	42808	140	90585493
Acute pulmonary oedema	20.57	12.46	24	42790	9556	90576077
Hypokalaemia	20.51	12.46	19	42795	131097	90454536
Leukopenia	20.48	12.46	11	42803	100699	90484934
Hypotonia	20.28	12.46	26	42788	11400	90574233
Intermittent positive pressure breathing	20.27	12.46	5	42809	63	90585570
Treatment noncompliance	20.18	12.46	62	42752	51665	90533968
Oropharyngeal pain	20.11	12.46	15	42799	115172	90470461
Genital blister	20.00	12.46	6	42808	163	90585470
Meconium abnormal	19.97	12.46	3	42811	0	90585633
Thrombocytopenia	19.95	12.46	43	42771	208682	90376951
Pulmonary valve disease	19.48	12.46	4	42810	20	90585613
Pulmonary valve stenosis congenital	19.37	12.46	6	42808	182	90585451
Cholestasis of pregnancy	19.36	12.46	11	42803	1566	90584067
Type 2 diabetes mellitus	19.34	12.46	163	42651	203081	90382552
Bradycardia foetal	19.29	12.46	8	42806	570	90585063
Sinusitis	19.20	12.46	90	42724	342998	90242635
Blood phosphorus increased	19.00	12.46	16	42798	4302	90581331
Sleep disorder	18.93	12.46	159	42655	197871	90387762
Pulmonary hypoplasia	18.88	12.46	7	42807	370	90585263
Hypopnoea	18.64	12.46	16	42798	4415	90581218
Haemoglobin decreased	18.45	12.46	30	42784	161926	90423707
Hypertension	18.41	12.46	311	42503	457221	90128412
Vulvovaginal ulceration	18.33	12.46	4	42810	28	90585605
Pancytopenia	18.14	12.46	18	42796	120245	90465388
Injection site pain	18.13	12.46	34	42780	173665	90411968
Atrial fibrillation	17.95	12.46	22	42792	133589	90452044
Jaundice neonatal	17.91	12.46	9	42805	1001	90584632
Jarisch-Herxheimer reaction	17.89	12.46	7	42807	429	90585204
Drug tolerance	17.71	12.46	31	42783	17885	90567748
Headache	17.69	12.46	294	42520	862452	89723181
Foetal exposure timing unspecified	17.69	12.46	7	42807	442	90585191
Syncope	17.66	12.46	22	42792	132641	90452992
Depressed mood	17.59	12.46	58	42756	50164	90535469
Wrong technique in product usage process	17.45	12.46	6	42808	71565	90514068
Fluid retention	17.37	12.46	10	42804	88081	90497552
Delayed delivery	17.34	12.46	4	42810	37	90585596
Joint stiffness	17.34	12.46	78	42736	77964	90507669
Aortic stenosis	17.29	12.46	18	42796	6318	90579315
Pneumocephalus	17.26	12.46	6	42808	263	90585370
Intraventricular haemorrhage neonatal	17.21	12.46	6	42808	265	90585368
Blood glucose increased	17.15	12.46	12	42802	95234	90490399
Colitis ulcerative	17.15	12.46	65	42749	60201	90525432
Osteoarthritis	17.07	12.46	154	42660	195576	90390057
Joint range of motion decreased	16.95	12.46	116	42698	135527	90450106
Angiotensin converting enzyme inhibitor foetopathy	16.88	12.46	4	42810	42	90585591
Tremor	16.87	12.46	29	42785	153144	90432489
Chronic hepatitis	16.85	12.46	9	42805	1136	90584497
Dyspnoea	16.84	12.46	304	42510	880651	89704982
Lip dry	16.82	12.46	93	42721	100862	90484771
Myalgia	16.80	12.46	36	42778	175089	90410544
Meningitis chemical	16.75	12.46	6	42808	287	90585346
Illness	16.60	12.46	9	42805	81960	90503673
Alanine aminotransferase increased	16.42	12.46	19	42795	118319	90467314
Anaemia folate deficiency	16.37	12.46	7	42807	539	90585094
Feeling abnormal	16.36	12.46	34	42780	167201	90418432
Breech presentation	15.99	12.46	9	42805	1258	90584375
Sleep disorder due to a general medical condition	15.96	12.46	52	42762	44686	90540947
Loss of consciousness	15.95	12.46	26	42788	140212	90445421
Eczema	15.86	12.46	58	42756	52812	90532821
Perioral dermatitis	15.83	12.46	7	42807	584	90585049
Activated partial thromboplastin time prolonged	15.80	12.46	19	42795	7806	90577827
Pulmonary haemorrhage neonatal	15.76	12.46	4	42810	57	90585576
Skin burning sensation	15.71	12.46	31	42783	19580	90566053
Influenza	15.67	12.46	26	42788	139238	90446395
Off label use	15.52	12.46	652	42162	1101600	89484033
Pustule	15.48	12.46	12	42802	2871	90582762
Blood pressure increased	15.45	12.46	45	42769	197172	90388461
Retroplacental haematoma	15.43	12.46	5	42809	176	90585457
Chest discomfort	15.41	12.46	26	42788	138339	90447294
Oesophageal atresia	15.40	12.46	7	42807	623	90585010
Arthralgia	15.40	12.46	267	42547	778255	89807378
Blood cholesterol increased	15.34	12.46	158	42656	207854	90377779
Foetal growth abnormality	15.33	12.46	4	42810	64	90585569
Anaemia neonatal	15.31	12.46	6	42808	369	90585264
Musculoskeletal stiffness	15.31	12.46	80	42734	296452	90289181
Right ventricular dysfunction	15.28	12.46	11	42803	2353	90583280
Oral candidiasis	15.26	12.46	44	42770	35411	90550222
Intentional product use issue	15.18	12.46	163	42651	216729	90368904
Somatostatin receptor scan abnormal	15.15	12.46	3	42811	12	90585621
Ultrasound uterus abnormal	15.10	12.46	4	42810	68	90585565
Platelet count decreased	15.02	12.46	26	42788	136943	90448690
Neuropathy peripheral	15.02	12.46	26	42788	136944	90448689
Tachycardia foetal	15.01	12.46	5	42809	192	90585441
Hyponatraemia	14.96	12.46	25	42789	133513	90452120
Arrhythmia neonatal	14.94	12.46	4	42810	71	90585562
Gestational hypertension	14.84	12.46	12	42802	3050	90582583
Fine motor delay	14.82	12.46	5	42809	200	90585433
Pneumocystis jirovecii pneumonia	14.77	12.46	32	42782	21584	90564049
Therapy interrupted	14.48	12.46	3	42811	50105	90535528
Hot flush	14.48	12.46	5	42809	59483	90526150
Tracheo-oesophageal fistula	14.46	12.46	7	42807	719	90584914
Blister	14.45	12.46	184	42630	254814	90330819
Breast injury	14.45	12.46	4	42810	81	90585552
Maternal exposure during delivery	14.40	12.46	13	42801	3833	90581800
Poor sucking reflex	14.32	12.46	6	42808	439	90585194
Periventricular leukomalacia	14.23	12.46	5	42809	226	90585407
Impetigo	14.23	12.46	9	42805	1557	90584076
Cardio-respiratory arrest	14.21	12.46	6	42808	63134	90522499
Vitiligo	14.06	12.46	10	42804	2100	90583533
Maternal exposure during breast feeding	14.06	12.46	16	42798	6204	90579429
Right aortic arch	14.01	12.46	5	42809	237	90585396
Sleep disorder therapy	13.81	12.46	6	42808	480	90585153
Red blood cell sedimentation rate increased	13.70	12.46	76	42738	82519	90503114
Skin plaque	13.63	12.46	20	42794	9955	90575678
Shared psychotic disorder	13.62	12.46	3	42811	22	90585611
Chills	13.62	12.46	26	42788	131955	90453678
Hypocholesterolaemia	13.59	12.46	16	42798	6433	90579200
Toxic anterior segment syndrome	13.48	12.46	10	42804	2240	90583393
Adrenal haematoma	13.39	12.46	3	42811	24	90585609
Vaccination site pruritus	13.39	12.46	3	42811	24	90585609
Libido increased	13.34	12.46	9	42805	1735	90583898
Umbilical artery vascular resistance increased	13.29	12.46	3	42811	25	90585608
Neonatal sinus tachycardia	13.29	12.46	3	42811	25	90585608
Small for dates baby	13.26	12.46	14	42800	4993	90580640
Amnesia	13.09	12.46	92	42722	108413	90477220
Overdose	13.08	12.46	35	42779	157674	90427959
Therapeutic product effect delayed	13.03	12.46	12	42802	3629	90582004
Rhabdomyolysis	13.02	12.46	4	42810	51252	90534381
Dermatitis atopic	13.01	12.46	32	42782	23440	90562193
End stage renal disease	12.91	12.46	18	42796	8553	90577080
Femur fracture	12.83	12.46	3	42811	46079	90539554
Disease progression	12.81	12.46	35	42779	156580	90429053
Pericoronitis	12.74	12.46	4	42810	127	90585506
Blood corticotrophin increased	12.74	12.46	4	42810	127	90585506
Treatment failure	12.72	12.46	208	42606	303720	90281913
Urticaria	12.71	12.46	213	42601	312521	90273112
Endocrine disorder	12.61	12.46	7	42807	953	90584680
Scab	12.58	12.46	19	42795	9702	90575931
Dysarthria	12.55	12.46	5	42809	54477	90531156
Umbilical cord prolapse	12.54	12.46	3	42811	33	90585600
Decreased insulin requirement	12.53	12.46	4	42810	134	90585499

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature baby	878.69	19.84	367	23289	22786	42574893
Low birth weight baby	553.06	19.84	208	23448	9747	42587932
Foetal exposure during pregnancy	478.27	19.84	308	23348	47003	42550676
Appendicolith	397.72	19.84	179	23477	13277	42584402
Stress	369.98	19.84	256	23400	43956	42553723
Appendicitis	347.56	19.84	187	23469	20426	42577253
Drug eruption	237.25	19.84	152	23504	22923	42574756
Cardiogenic shock	233.39	19.84	178	23478	35462	42562217
Blood phosphorus increased	189.95	19.84	106	23550	12419	42585260
Ventricular fibrillation	189.64	19.84	147	23509	29976	42567703
Ascites	189.12	19.84	193	23463	56485	42541194
Pain in extremity	180.98	19.84	310	23346	150294	42447385
Pulmonary vasculitis	158.92	19.84	75	23581	6191	42591488
Stomatitis	147.56	19.84	160	23496	50169	42547510
Neuritis	147.23	19.84	71	23585	6149	42591530
Abdominal distension	147.22	19.84	190	23466	71545	42526134
Catarrh	146.76	19.84	70	23586	5916	42591763
Burns second degree	145.55	19.84	70	23586	6026	42591653
Hepatic function abnormal	144.35	19.84	160	23496	51407	42546272
Steroid dependence	136.13	19.84	69	23587	6653	42591026
Eosinophilic granulomatosis with polyangiitis	130.67	19.84	73	23583	8565	42589114
Parosmia	130.16	19.84	70	23586	7621	42590058
Hypopnoea	128.55	19.84	70	23586	7812	42589867
Urticaria	127.39	19.84	180	23476	73856	42523823
Gingival pain	126.36	19.84	71	23585	8423	42589256
Systemic lupus erythematosus	125.48	19.84	73	23583	9251	42588428
Myasthenia gravis	124.46	19.84	89	23567	16048	42581631
Respiratory symptom	123.70	19.84	77	23579	11029	42586650
Neurological symptom	120.80	19.84	73	23583	9918	42587761
Hyponatraemia	117.96	19.84	206	23450	101256	42496423
Pulmonary embolism	115.33	19.84	224	23432	119388	42478291
Total lung capacity abnormal	115.19	19.84	54	23602	4389	42593290
Loss of personal independence in daily activities	115.00	19.84	140	23516	49676	42548003
Hypersensitivity	114.35	19.84	169	23487	72201	42525478
Pulmonary alveolar haemorrhage	110.34	19.84	80	23576	14736	42582943
Eczema	108.06	19.84	113	23543	33973	42563706
Multiple organ dysfunction syndrome	107.61	19.84	193	23463	96842	42500837
Bronchiectasis	107.02	19.84	85	23571	17934	42579745
Rhinitis	106.27	19.84	72	23584	11905	42585774
Epistaxis	102.61	19.84	154	23502	66672	42531007
Blood uric acid increased	102.45	19.84	78	23578	15469	42582210
Toxicity to various agents	100.19	19.84	7	23649	229129	42368550
Cardiac murmur	97.46	19.84	70	23586	12705	42584974
Mite allergy	96.96	19.84	50	23606	4996	42592683
Neonatal respiratory distress syndrome	96.29	19.84	48	23608	4465	42593214
Impaired work ability	96.26	19.84	68	23588	12023	42585656
Alcohol poisoning	95.87	19.84	57	23599	7517	42590162
Patent ductus arteriosus	95.56	19.84	44	23612	3432	42594247
Mycotic allergy	95.53	19.84	49	23607	4842	42592837
Dust allergy	94.36	19.84	50	23606	5282	42592397
Conjunctivitis allergic	92.26	19.84	51	23605	5860	42591819
Antineutrophil cytoplasmic antibody positive	91.88	19.84	46	23610	4319	42593360
Spirometry abnormal	90.34	19.84	48	23608	5098	42592581
Forced expiratory volume decreased	90.31	19.84	55	23601	7575	42590104
Blood cholesterol increased	88.98	19.84	91	23565	26650	42571029
Frequent bowel movements	88.39	19.84	82	23574	21325	42576354
Pulmonary fibrosis	87.34	19.84	90	23566	26591	42571088
Condition aggravated	86.63	19.84	329	23327	260425	42337254
Dry mouth	85.47	19.84	108	23548	39771	42557908
Hyperphosphataemia	85.15	19.84	65	23591	12939	42584740
Drug ineffective	85.09	19.84	618	23038	629579	41968100
Acute kidney injury	81.33	19.84	52	23604	367285	42230394
Muscle spasms	80.26	19.84	159	23497	85885	42511794
Vasculitis	78.93	19.84	72	23584	18322	42579357
Obstructive airways disorder	78.32	19.84	82	23574	24677	42573002
Impaired quality of life	78.08	19.84	64	23592	14113	42583566
Therapeutic product effect incomplete	77.19	19.84	140	23516	70799	42526880
Normochromic normocytic anaemia	74.70	19.84	52	23604	8979	42588700
Atrial septal defect	73.59	19.84	49	23607	7870	42589809
Swollen tongue	72.00	19.84	73	23583	21158	42576521
Iron deficiency	71.79	19.84	55	23601	11006	42586673
Hypothyroidism	70.51	19.84	88	23568	31996	42565683
Sleep disorder due to a general medical condition	68.49	19.84	65	23591	17388	42580291
Colitis ulcerative	67.70	19.84	78	23578	26097	42571582
Thrombosis	65.56	19.84	128	23528	68383	42529296
Incorrect route of product administration	65.52	19.84	74	23582	24231	42573448
Nightmare	65.48	19.84	75	23581	24937	42572742
Sleep disorder therapy	64.89	19.84	43	23613	6851	42590828
Analgesic therapy	64.59	19.84	42	23614	6482	42591197
Diarrhoea	64.30	19.84	98	23558	460751	42136928
Capillaritis	63.75	19.84	29	23627	2199	42595480
Migraine	62.84	19.84	74	23582	25340	42572339
Neuralgia	62.29	19.84	74	23582	25573	42572106
Nodule	61.62	19.84	53	23603	12481	42585198
Somnolence	59.67	19.84	193	23463	140912	42456767
Full blood count abnormal	59.44	19.84	78	23578	29798	42567881
Hypophosphataemia	58.57	19.84	65	23591	20880	42576799
Accidental overdose	57.97	19.84	75	23581	28255	42569424
Fall	56.35	19.84	30	23626	234490	42363189
Sleep disorder	56.25	19.84	98	23558	47997	42549682
Medication error	56.05	19.84	80	23576	33074	42564605
Drug therapy	55.75	19.84	38	23618	6342	42591337
Vertigo	55.33	19.84	81	23575	34266	42563413
Constipation	54.77	19.84	206	23450	162085	42435594
Tinnitus	53.66	19.84	73	23583	28865	42568814
Foetal growth restriction	52.27	19.84	34	23622	5249	42592430
Sepsis	50	19.84	231	23425	199103	42398576
General physical health deterioration	49.39	19.84	190	23466	151056	42446623
Asthenia	48.11	19.84	51	23605	280742	42316937
Abdominal pain	47.97	19.84	221	23435	190250	42407429
Hypotension	47.34	19.84	44	23612	257587	42340092
Arteriosclerosis coronary artery	47.19	19.84	55	23601	18622	42579057
Dysgeusia	47.12	19.84	75	23581	34114	42563565
Drug interaction	46.29	19.84	48	23608	266951	42330728
Haemoptysis	46.28	19.84	88	23568	46079	42551600
Total lung capacity decreased	45.52	19.84	27	23629	3543	42594136
Bacterial infection	45.26	19.84	66	23590	27813	42569866
Drug abuse	43.51	19.84	4	23652	104767	42492912
Product use in unapproved indication	42.78	19.84	209	23447	184247	42413432
Arteriosclerosis	42.19	19.84	51	23605	17938	42579741
Rectal haemorrhage	41.86	19.84	88	23568	49518	42548161
Tubulointerstitial nephritis	41.82	19.84	68	23588	31480	42566199
Dizziness	40.78	19.84	47	23609	249207	42348472
Arthritis	40.71	19.84	79	23577	41986	42555693
Death	39.63	19.84	132	23524	471053	42126626
Palpitations	39.30	19.84	87	23569	50710	42546969
Wheezing	39.24	19.84	91	23565	54690	42542989
Foetal heart rate deceleration abnormality	39.17	19.84	14	23642	565	42597114
Back pain	38.91	19.84	15	23641	141761	42455918
Haemoglobin decreased	38.08	19.84	13	23643	132458	42465221
Skin exfoliation	37.75	19.84	76	23580	41477	42556202
Lung disorder	36.98	19.84	82	23574	47841	42549838
Asthma	35.65	19.84	95	23561	62219	42535460
Thrombocytopenia	35.52	19.84	32	23624	190247	42407432
Aortic stenosis	35.12	19.84	33	23623	8712	42588967
Cough	34.39	19.84	29	23627	178074	42419605
Septum pellucidum agenesis	34.33	19.84	8	23648	65	42597614
Cardiac failure congestive	33.65	19.84	4	23652	85598	42512081
Lung opacity	33.50	19.84	27	23629	5810	42591869
Neutropenia	33.26	19.84	37	23619	199394	42398285
White blood cell count decreased	33.20	19.84	10	23646	110386	42487293
Myocardial infarction	32.60	19.84	14	23642	123995	42473684
Psoriasis	31.85	19.84	78	23578	48526	42549153
Cardiac failure	31.56	19.84	10	23646	106846	42490833
Bacteroides infection	31.51	19.84	19	23637	2568	42595111
Pancytopenia	31.42	19.84	13	23643	117730	42479949
Steroid withdrawal syndrome	30.83	19.84	10	23646	299	42597380
Diabetes mellitus	30.80	19.84	88	23568	59999	42537680
Platelet count decreased	30.05	19.84	20	23636	138561	42459118
Decreased appetite	29.89	19.84	38	23618	193099	42404580
Rhabdomyolysis	29.81	19.84	4	23652	78015	42519664
Antacid therapy	29.61	19.84	23	23633	4694	42592985
Dehydration	28.72	19.84	22	23634	141745	42455934
Inappropriate schedule of product administration	28.46	19.84	117	23539	95785	42501894
Polydipsia	28.42	19.84	22	23634	4466	42593213
Premature delivery	28.40	19.84	8	23648	146	42597533
Haematochezia	27.48	19.84	83	23573	58353	42539326
Disease progression	26.98	19.84	24	23632	143632	42454047
Congenital hearing disorder	26.78	19.84	7	23649	95	42597584
Alanine aminotransferase increased	26.59	19.84	8	23648	88398	42509281
Intentional product misuse	26.41	19.84	85	23571	61815	42535864
Nasopharyngitis	26.38	19.84	7	23649	83989	42513690
Adverse drug reaction	25.51	19.84	61	23595	37373	42560306
Maternal exposure during pregnancy	25.50	19.84	25	23631	6953	42590726
Bronchopulmonary dysplasia	25.34	19.84	11	23645	746	42596933
Congenital cystic lung	25.20	19.84	8	23648	223	42597456
Blood calcium increased	24.95	19.84	27	23629	8427	42589252
Neonatal respiratory failure	24.81	19.84	9	23647	379	42597300
Renal failure	24.69	19.84	26	23630	143700	42453979
Gait disturbance	24.30	19.84	12	23644	97988	42499691
Corneal endotheliitis	24.11	19.84	6	23650	66	42597613
Seizure	24.04	19.84	19	23637	120542	42477137
Anticoagulant therapy	23.98	19.84	20	23636	4515	42593164
End stage renal disease	23.74	19.84	37	23619	16521	42581158
Loss of consciousness	23.36	19.84	11	23645	92343	42505336
Oxygen saturation decreased	23.15	19.84	4	23652	64683	42532996
Ciliary hyperaemia	22.50	19.84	5	23651	32	42597647
Cardiac arrest	22.09	19.84	17	23639	109303	42488376
Atrial fibrillation	22.07	19.84	27	23629	139566	42458113
Infection	21.92	19.84	18	23638	112050	42485629
Weight increased	21.55	19.84	17	23639	107966	42489713
Renal impairment	21.20	19.84	18	23638	110210	42487469
Ulcer	21.19	19.84	35	23621	16406	42581273
Hypertrophic cardiomyopathy	21.12	19.84	12	23644	1453	42596226
Perioral dermatitis	20.98	19.84	7	23649	229	42597450
Joint swelling	20.74	19.84	6	23650	68016	42529663
Activated partial thromboplastin time prolonged	20.69	19.84	34	23622	15869	42581810
Overdose	20.47	19.84	17	23639	105247	42492432
Hydrops foetalis	20.42	19.84	10	23646	895	42596784
Respiratory disorder neonatal	20.28	19.84	13	23643	1957	42595722
Polyhydramnios	20.24	19.84	7	23649	256	42597423
Skin erosion	20.14	19.84	15	23641	2876	42594803
Persistent corneal epithelial defect	20.09	19.84	5	23651	55	42597624
Vertical infection transmission	19.98	19.84	4	23652	14	42597665
Cryptorchism	19.94	19.84	13	23643	2014	42595665
Congenital pulmonary valve atresia	19.85	19.84	5	23651	58	42597621

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Premature delivery	1239.14	13.26	497	56033	30135	110502634
Maternal exposure during pregnancy	703.50	13.26	754	55776	254129	110278640
Appendicolith	453.55	13.26	195	56335	14060	110518709
Exposure during pregnancy	443.31	13.26	485	56045	166939	110365830
Appendicitis	346.90	13.26	203	56327	28261	110504508
Stress	255.99	13.26	292	56238	105056	110427713
Blood phosphorus increased	216.29	13.26	123	56407	16217	110516552
Cardiogenic shock	196.54	13.26	191	56339	57147	110475622
Catarrh	177.88	13.26	83	56447	7252	110525517
Ventricular fibrillation	175.24	13.26	155	56375	41158	110491611
Burns second degree	173.69	13.26	83	56447	7650	110525119
Ascites	171.40	13.26	224	56306	92584	110440185
Infusion site reaction	169.03	13.26	108	56422	17574	110515195
Premature labour	168.94	13.26	86	56444	9086	110523683
Steroid dependence	163.57	13.26	82	56448	8387	110524382
Pulmonary vasculitis	161.47	13.26	75	56455	6485	110526284
Drug eruption	158.66	13.26	165	56365	53494	110479275
Neuritis	146.92	13.26	73	56457	7326	110525443
Hypopnoea	143.49	13.26	83	56447	11297	110521472
Blood uric acid increased	136.19	13.26	102	56428	21427	110511342
Blepharospasm	133.10	13.26	152	56378	54699	110478070
Computerised tomogram thorax abnormal	132.78	13.26	51	56479	2744	110530025
Parosmia	132.22	13.26	83	56447	13097	110519672
Toxicity to various agents	129.83	13.26	42	56488	480513	110052256
Gingival pain	128.25	13.26	87	56443	15649	110517120
Pre-eclampsia	125.04	13.26	69	56461	8581	110524188
Acute kidney injury	125.03	13.26	86	56444	635344	109897425
Myasthenia gravis	123.08	13.26	96	56434	21415	110511354
Eosinophilic granulomatosis with polyangiitis	121.76	13.26	73	56457	10613	110522156
Live birth	119.50	13.26	162	56368	69322	110463447
Total lung capacity abnormal	117.80	13.26	54	56476	4529	110528240
Fall	114.36	13.26	85	56445	603397	109929372
Hyperphosphataemia	113.52	13.26	82	56448	16299	110516470
Respiratory symptom	113.24	13.26	79	56451	14866	110517903
Product use in unapproved indication	111.94	13.26	489	56041	446888	110085881
Back injury	109.38	13.26	128	56402	47271	110485498
Analgesic therapy	107.76	13.26	59	56471	7225	110525544
Hepatic function abnormal	105.97	13.26	175	56355	89120	110443649
Eczema	102.88	13.26	154	56376	72139	110460630
Computerised tomogram thorax	102.36	13.26	28	56502	498	110532271
Urticaria	101.69	13.26	376	56154	318481	110214288
Rhinitis	100.44	13.26	87	56443	22458	110510311
Conjunctivitis allergic	99.40	13.26	55	56475	6876	110525893
Neurological symptom	98.84	13.26	74	56456	15534	110517235
Hypercholesterolaemia	97.19	13.26	170	56360	90667	110442102
Drug therapy	96.80	13.26	55	56475	7236	110525533
Alcohol poisoning	96.04	13.26	59	56471	8961	110523808
Dry mouth	95.72	13.26	271	56259	199677	110333092
Frequent bowel movements	94.42	13.26	147	56383	71243	110461526
Steroid withdrawal syndrome	94.36	13.26	30	56500	915	110531854
Mite allergy	94.22	13.26	50	56480	5753	110527016
Premature baby	93.74	13.26	47	56483	4808	110527961
Dust allergy	92.64	13.26	50	56480	5951	110526818
Diarrhoea	92.41	13.26	288	56242	1139217	109393552
Spirometry abnormal	91.05	13.26	48	56482	5449	110527320
Mycotic allergy	90.22	13.26	49	56481	5905	110526864
Cardiac murmur	89.97	13.26	85	56445	24543	110508226
Abdominal distension	89.41	13.26	243	56287	174860	110357909
Antineutrophil cytoplasmic antibody positive	88.87	13.26	46	56484	5030	110527739
Bronchiectasis	88.31	13.26	101	56429	36392	110496377
Pulmonary alveolar haemorrhage	88.24	13.26	77	56453	20073	110512696
Nightmare	86.44	13.26	103	56427	38760	110494009
Medication error	84.03	13.26	174	56356	105192	110427577
Incorrect route of product administration	83.45	13.26	131	56399	63930	110468839
Hypotension	83.26	13.26	87	56443	523762	110009007
Sleep disorder therapy	82.44	13.26	50	56480	7421	110525348
Pulmonary embolism	82.31	13.26	269	56261	214205	110318564
Stomatitis	82.25	13.26	314	56216	269928	110262841
Epilepsy	81.70	13.26	167	56363	100042	110432727
Colitis ulcerative	77.89	13.26	141	56389	77222	110455547
Therapeutic product effect incomplete	77.33	13.26	271	56259	223534	110309235
Multiple organ dysfunction syndrome	76.91	13.26	210	56320	151500	110381269
Taste disorder	74.70	13.26	126	56404	65261	110467508
Impaired work ability	74.09	13.26	79	56451	26340	110506429
Premature rupture of membranes	72.60	13.26	39	56491	4598	110528171
Breast cancer stage III	71.91	13.26	138	56392	78979	110453790
Neutropenia	71.88	13.26	52	56478	374568	110158201
Sleep disorder	71.64	13.26	244	56286	198400	110334369
Blood pressure inadequately controlled	71.41	13.26	46	56484	7587	110525182
Normal newborn	71.39	13.26	71	56459	21825	110510944
Psoriasis	71.17	13.26	194	56336	139799	110392970
Normochromic normocytic anaemia	67.69	13.26	55	56475	13002	110519767
Impaired quality of life	67.49	13.26	80	56450	29937	110502832
Forced expiratory volume decreased	67.26	13.26	55	56475	13121	110519648
Antacid therapy	66.49	13.26	39	56491	5445	110527324
Preterm premature rupture of membranes	66.14	13.26	26	56504	1489	110531280
Drug abuse	65.82	13.26	7	56523	177404	110355365
Muscle spasms	65.65	13.26	299	56231	277858	110254911
Caesarean section	64.97	13.26	55	56475	13762	110519007
Blood cholesterol increased	64.03	13.26	224	56306	184561	110348208
Capillaritis	63.51	13.26	29	56501	2410	110530359
Onychomadesis	63.14	13.26	96	56434	45567	110487202
Dehydration	63.11	13.26	32	56498	279479	110253290
Iron deficiency	62.26	13.26	61	56469	18415	110514354
Corneal endotheliitis	61.19	13.26	14	56516	114	110532655
Liver function test increased	61.18	13.26	138	56392	88410	110444359
Gestational diabetes	60.56	13.26	41	56489	7348	110525421
Drug interaction	60.16	13.26	102	56428	500081	110032688
Haemoglobin decreased	59.97	13.26	26	56504	248701	110284068
Anticoagulant therapy	59.47	13.26	36	56494	5325	110527444
Aortic stenosis	59.40	13.26	51	56479	13008	110519761
Sleep disorder due to a general medical condition	58.97	13.26	100	56430	52012	110480757
Overlap syndrome	57.47	13.26	43	56487	9016	110523753
Foetal growth restriction	57.34	13.26	29	56501	3021	110529748
Exercise tolerance decreased	56.67	13.26	48	56482	12019	110520750
Skin exfoliation	56.58	13.26	133	56397	87518	110445251
Lung disorder	56.23	13.26	211	56319	179836	110352933
Rectal haemorrhage	55.93	13.26	161	56369	119672	110413097
Pain in extremity	55.87	13.26	433	56097	486685	110046084
Epistaxis	55	13.26	169	56361	130203	110402566
General physical health deterioration	54.42	13.26	388	56142	424907	110107862
Gastrooesophageal reflux disease	53.80	13.26	208	56322	179768	110353001
Condition aggravated	53.35	13.26	592	55938	734244	109798525
Fatigue	53.13	13.26	384	56146	1215574	109317195
Thrombocytopenia	53.10	13.26	60	56470	348825	110183944
Product quality issue	52.87	13.26	120	56410	77179	110455590
Seizure	51.94	13.26	24	56506	221161	110311608
Tubulointerstitial nephritis	50.94	13.26	96	56434	54188	110478581
Macular degeneration	50.81	13.26	59	56471	21600	110511169
Death	50.77	13.26	185	56345	698684	109834085
Multiple drug therapy	50.75	13.26	38	56492	7976	110524793
White blood cell count decreased	50.68	13.26	27	56503	229363	110303406
Hypophosphataemia	50.53	13.26	73	56457	33109	110499660
Renal failure	49.57	13.26	27	56503	226547	110306222
Pulmonary fibrosis	49.47	13.26	139	56391	101903	110430866
Tinnitus	49.46	13.26	101	56429	60439	110472330
Hypoxia	49.25	13.26	162	56368	129353	110403416
Bacterial infection	49.02	13.26	86	56444	45950	110486819
Cardiac failure congestive	48.89	13.26	9	56521	150991	110381778
Swollen tongue	48.48	13.26	100	56430	60262	110472507
Vasculitis	47.60	13.26	74	56456	35799	110496970
Neuralgia	47.07	13.26	87	56443	48391	110484378
Thrombosis	46.90	13.26	142	56388	108520	110424249
Bradycardia	46.78	13.26	11	56519	155506	110377263
Obstructive airways disorder	46.30	13.26	84	56446	46065	110486704
Infection	46.21	13.26	71	56459	362129	110170640
Back pain	46.12	13.26	74	56456	370922	110161847
Diabetes mellitus inadequate control	46.07	13.26	66	56464	29709	110503060
Urinary tract infection	45.55	13.26	60	56470	326222	110206547
Accidental overdose	45.37	13.26	89	56441	51745	110481024
Peripheral venous disease	45.19	13.26	119	56411	83998	110448771
Decreased appetite	44.53	13.26	112	56418	475734	110057035
Chronic sinusitis	43.90	13.26	59	56471	25025	110507744
Atelectasis	43.60	13.26	72	56458	36640	110496129
Hyponatraemia	43.43	13.26	223	56307	217430	110315339
Myocardial infarction	43.33	13.26	22	56508	192061	110340708
Facet joint syndrome	43.17	13.26	128	56402	96700	110436069
Loss of personal independence in daily activities	42.10	13.26	170	56360	149850	110382919
Haematochezia	41.70	13.26	142	56388	115382	110417387
Total lung capacity decreased	41.24	13.26	32	56498	7082	110525687
End stage renal disease	39.88	13.26	52	56478	21421	110511348
Cardiac arrest	39.45	13.26	26	56504	196727	110336042
Arteriosclerosis coronary artery	39.33	13.26	56	56474	25062	110507707
Adverse drug reaction	39.21	13.26	131	56399	105428	110427341
Pancytopenia	39.01	13.26	30	56500	209583	110323186
Intentional overdose	38.63	13.26	10	56520	132491	110400278
Migraine	38.61	13.26	182	56348	171470	110361299
Dysgeusia	38.61	13.26	100	56430	69885	110462884
Activated partial thromboplastin time prolonged	38.21	13.26	52	56478	22316	110510453
Vertigo	37.93	13.26	114	56416	86756	110446013
Depressed level of consciousness	37.87	13.26	6	56524	112272	110420497
Perioral dermatitis	37.29	13.26	14	56516	707	110532062
Rhabdomyolysis	37.25	13.26	8	56522	120393	110412376
Heart rate increased	36.34	13.26	14	56516	143820	110388949
Coma	36.12	13.26	8	56522	117861	110414908
Arthralgia	36.03	13.26	242	56288	779390	109753379
Intentional product use issue	35.73	13.26	233	56297	247673	110285096
Polyhydramnios	35.23	13.26	18	56512	1915	110530854
Asthenia	34.84	13.26	208	56322	688791	109843978
Oligohydramnios	34.75	13.26	23	56507	3971	110528798
Paraesthesia oral	34.69	13.26	62	56468	33609	110499160
Alanine aminotransferase increased	34.58	13.26	26	56504	183747	110349022
Wound infection	34.31	13.26	118	56412	96347	110436422
Amniotic cavity infection	34.17	13.26	14	56516	893	110531876
Arteriosclerosis	34.14	13.26	52	56478	24715	110508054
Hypothyroidism	34.06	13.26	98	56432	72801	110459968
Lung opacity	32.95	13.26	35	56495	11617	110521152
Platelet count decreased	32.53	13.26	42	56488	230401	110302368
Shared psychotic disorder	32.46	13.26	7	56523	42	110532727
Blood calcium increased	32.44	13.26	43	56487	17997	110514772
Full blood count abnormal	31.85	13.26	81	56449	55971	110476798
Somnolence	31.64	13.26	260	56270	297189	110235580
Overdose	31.59	13.26	44	56486	233750	110299019
Haemoptysis	31.49	13.26	94	56436	71260	110461509
Skin weeping	31.27	13.26	21	56509	3714	110529055
HELLP syndrome	31.24	13.26	13	56517	863	110531906
Bacteroides infection	30.84	13.26	19	56511	2900	110529869
International normalised ratio increased	30.75	13.26	4	56526	86768	110446001
Ophthalmic herpes simplex	30.71	13.26	13	56517	901	110531868
Cardiac failure	29.93	13.26	31	56499	187595	110345174
Myelosuppression	29.74	13.26	6	56524	94334	110438435
Rectal cancer metastatic	29.60	13.26	11	56519	540	110532229
Pulmonary valve stenosis congenital	29.43	13.26	5	56525	5	110532764
Placental insufficiency	29.40	13.26	14	56516	1280	110531489
Hypokalaemia	29.27	13.26	30	56500	182418	110350351
Sinusitis	29.18	13.26	68	56462	296620	110236149
Cerebral haemorrhage neonatal	28.96	13.26	5	56525	6	110532763
Syncope	28.50	13.26	37	56493	202499	110330270
Joint swelling	28.44	13.26	123	56407	442722	110090047
Mental status changes	28.24	13.26	3	56527	76119	110456650
Diabetes mellitus	28.18	13.26	113	56417	99268	110433501
Leukopenia	28.06	13.26	21	56509	148770	110383999
Female genital tract fistula	27.61	13.26	38	56492	16481	110516288
Blood test abnormal	27.41	13.26	51	56479	28503	110504266
Hypothalamic pituitary adrenal axis suppression	27.32	13.26	11	56519	671	110532098
Oxygen saturation decreased	27.30	13.26	24	56506	156958	110375811
Blood glucose increased	27.25	13.26	17	56513	132479	110400290
Radiculopathy	27.22	13.26	41	56489	19295	110513474
Constipation	26.68	13.26	290	56240	357496	110175273
Loss of consciousness	26.47	13.26	37	56493	196269	110336500
Foetal heart rate disorder	26.32	13.26	6	56524	48	110532721
Suicide attempt	26.22	13.26	10	56520	103384	110429385
Cervical incompetence	26.05	13.26	10	56520	537	110532232
Neck pain	25.84	13.26	128	56402	123002	110409767
Foetal exposure during pregnancy	25.70	13.26	25	56505	7480	110525289
Disease progression	25.58	13.26	54	56476	243980	110288789
Systemic lupus erythematosus	25.28	13.26	219	56311	254119	110278650
Gout	25.26	13.26	57	56473	36509	110496260
Lactic acidosis	25.22	13.26	8	56522	92803	110439966
Procedural pain	25.20	13.26	56	56474	35509	110497260
Hypoglycaemia	25.15	13.26	14	56516	116090	110416679
Vaginal flatulence	25.07	13.26	31	56499	12113	110520656
Nodule	24.96	13.26	53	56477	32578	110500191
Blood pressure increased	24.78	13.26	60	56470	258313	110274456
Atrial fibrillation	24.75	13.26	50	56480	229592	110303177
Obesity	24.62	13.26	119	56411	113232	110419537
Hyperkalaemia	24.55	13.26	20	56510	135776	110396993
Night sweats	24.46	13.26	134	56396	133849	110398920
Bursitis	24.44	13.26	131	56399	129787	110402982
Illness	24.34	13.26	6	56524	82165	110450604
Corneal perforation	23.74	13.26	11	56519	945	110531824
Gait disturbance	23.36	13.26	69	56461	278139	110254630
Acute respiratory failure	23.28	13.26	5	56525	75255	110457514
Drug ineffective	23.15	13.26	973	55557	1519567	109013202
Maternal condition affecting foetus	22.97	13.26	7	56523	185	110532584
Myalgia	22.65	13.26	50	56480	222331	110310438
Fluid retention	22.49	13.26	10	56520	94297	110438472
Ulcerative keratitis	22.46	13.26	19	56511	4747	110528022
Sepsis	22.44	13.26	261	56269	327085	110205684
Lethargy	22.20	13.26	10	56520	93566	110439203
Hypertension	22.13	13.26	375	56155	509709	110023060
Genital blister	21.91	13.26	7	56523	217	110532552
Chills	21.84	13.26	40	56490	190540	110342229
Hepatic cirrhosis	21.71	13.26	80	56450	67546	110465223
Hyperlipidaemia	21.62	13.26	53	56477	35795	110496974
Polydipsia	21.57	13.26	23	56507	7665	110525104
Dysarthria	21.56	13.26	8	56522	84113	110448656
Chest pain	21.52	13.26	109	56421	376266	110156503
Neonatal gastrointestinal disorder	21.41	13.26	5	56525	45	110532724
Polyglandular disorder	21.26	13.26	7	56523	239	110532530
Tremor	20.98	13.26	45	56485	202187	110330582
Depression	20.86	13.26	251	56279	317084	110215685
Cholestasis of pregnancy	20.82	13.26	11	56519	1254	110531515
Foetal hypokinesia	20.82	13.26	8	56522	431	110532338
Influenza	20.74	13.26	34	56496	169067	110363702
Nail disorder	20.71	13.26	71	56459	57864	110474905
Renal impairment	20.33	13.26	41	56489	188404	110344365
Insomnia	20.29	13.26	105	56425	360485	110172284
Gait inability	20.14	13.26	129	56401	136247	110396522
Respiratory arrest	19.92	13.26	3	56527	58296	110474473
Injection site pain	19.81	13.26	38	56492	177884	110354885
Vaginal discharge	19.77	13.26	34	56496	17874	110514895
Feeling abnormal	19.77	13.26	39	56491	180672	110352097
Inappropriate schedule of product administration	19.53	13.26	174	56356	203463	110329306
Bone erosion	19.44	13.26	60	56470	46311	110486458
Type 2 diabetes mellitus	19.41	13.26	156	56374	177076	110355693
Foetal heart rate deceleration abnormality	19.36	13.26	6	56524	168	110532601
Psoriatic arthropathy	19.32	13.26	169	56361	196592	110336177
Breast cancer stage II	19.27	13.26	43	56487	27332	110505437
Haematocrit decreased	19.25	13.26	5	56525	66112	110466657
Ciliary hyperaemia	19.14	13.26	5	56525	74	110532695
Starvation ketoacidosis	19.09	13.26	7	56523	331	110532438
Product dose omission issue	19.08	13.26	92	56438	321690	110211079
Hypocalcaemia	18.92	13.26	5	56525	65361	110467408
Patent ductus arteriosus	18.87	13.26	6	56524	183	110532586
Agitation	18.81	13.26	18	56512	113033	110419736
Vulvovaginal ulceration	18.69	13.26	4	56526	23	110532746
Delayed delivery	18.69	13.26	4	56526	23	110532746
Chest discomfort	18.61	13.26	38	56492	173810	110358959
Neonatal respiratory depression	18.38	13.26	5	56525	87	110532682
Hallucination	18.26	13.26	15	56515	101417	110431352
Malaise	18.25	13.26	238	56292	671581	109861188
Unresponsive to stimuli	18.24	13.26	5	56525	63785	110468984
Dyspnoea exertional	17.98	13.26	16	56514	104044	110428725
Chronic obstructive pulmonary disease	17.84	13.26	106	56424	109052	110423717
Oropharyngeal pain	17.73	13.26	26	56504	135250	110397519
Skin infection	17.73	13.26	37	56493	22472	110510297
Wheezing	17.70	13.26	204	56326	255026	110277743
Neuropathy peripheral	17.69	13.26	41	56489	179236	110353533
Ulcer haemorrhage	17.66	13.26	37	56493	22534	110510235
Weight increased	17.52	13.26	134	56396	419510	110113259
Atrial septal defect	17.51	13.26	12	56518	2193	110530576
Orthostatic hypotension	17.49	13.26	6	56524	66243	110466526
Persistent corneal epithelial defect	17.45	13.26	5	56525	106	110532663
Gestational hypertension	17.37	13.26	12	56518	2222	110530547
Proctitis	17.22	13.26	31	56499	16896	110515873
Neutrophil count decreased	17.11	13.26	22	56508	120919	110411850
Gastrointestinal haemorrhage	17.03	13.26	37	56493	165481	110367288
Troponin increased	16.89	13.26	43	56487	29723	110503046
Dyskinesia	16.79	13.26	3	56527	51443	110481326
Helicobacter infection	16.72	13.26	154	56376	181723	110351046
Heart rate decreased	16.50	13.26	11	56519	82745	110450024
Osteoarthritis	16.47	13.26	154	56376	182469	110350300
Retroplacental haematoma	16.27	13.26	5	56525	136	110532633
Aggression	16.27	13.26	5	56525	59205	110473564
Disorientation	16.07	13.26	8	56522	70663	110462106
Therapy interrupted	16.06	13.26	3	56527	49819	110482950
Anaplastic astrocytoma	15.87	13.26	5	56525	148	110532621
Angina pectoris	15.84	13.26	6	56524	62289	110470480
Abdominal pain	15.76	13.26	358	56172	512631	110020138
Hot flush	15.75	13.26	7	56523	66029	110466740
Low birth weight baby	15.70	13.26	8	56522	847	110531922
Dermatitis atopic	15.66	13.26	38	56492	25503	110507266
Skin erosion	15.53	13.26	17	56513	5837	110526932
Meningitis chemical	14.93	13.26	6	56524	364	110532405
Depressed mood	14.79	13.26	66	56464	60743	110472026
Anaemia	14.77	13.26	194	56336	546892	109985877
Foetal distress syndrome	14.70	13.26	7	56523	640	110532129
Ulcer	14.68	13.26	52	56478	43064	110489705
Pneumonia aspiration	14.64	13.26	12	56518	81221	110451548
Encephalopathy	14.57	13.26	12	56518	81043	110451726
Intentional product misuse	14.56	13.26	117	56413	132787	110399982
Pulmonary hilum mass	14.54	13.26	6	56524	390	110532379
Lichenification	14.45	13.26	8	56522	1001	110531768
Impaired healing	14.44	13.26	159	56371	196558	110336211
Glycogen storage disorder	14.37	13.26	3	56527	15	110532754
Somatostatin receptor scan abnormal	14.37	13.26	3	56527	15	110532754
Breast injury	14.23	13.26	4	56526	79	110532690
Arthritis allergic	14.21	13.26	3	56527	16	110532753
Rhinorrhoea	14.19	13.26	19	56511	102647	110430122
Anaemia folate deficiency	14.16	13.26	7	56523	694	110532075
Maternal exposure before pregnancy	14.13	13.26	18	56512	7247	110525522
Chronic kidney disease	14.08	13.26	11	56519	76280	110456489
Cardiac disorder	14.08	13.26	11	56519	76269	110456500
Shock	13.89	13.26	5	56525	53583	110479186
Gamma-glutamyltransferase increased	13.85	13.26	7	56523	61302	110471467
Umbilical cord prolapse	13.77	13.26	3	56527	19	110532750
Lymphocyte count decreased	13.76	13.26	6	56524	57237	110475532
Exostosis	13.62	13.26	53	56477	45903	110486866
Oral candidiasis	13.58	13.26	52	56478	44708	110488061
Bronchopulmonary aspergillosis allergic	13.51	13.26	19	56511	8407	110524362
Adrenal insufficiency	13.48	13.26	50	56480	42340	110490429
Post inflammatory pigmentation change	13.48	13.26	7	56523	770	110531999
Injection site erythema	13.45	13.26	17	56513	94159	110438610
Pain	13.34	13.26	379	56151	954576	109578193

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A07EA04	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally
ATC	C05AA05	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Corticosteroids
ATC	D07AC01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III)
ATC	D07BC01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, potent, combinations with antiseptics
ATC	D07CC01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, potent, combinations with antibiotics
ATC	D07XC01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, potent, other combinations
ATC	H02AB01	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Glucocorticoids
ATC	R01AD06	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids
ATC	R03BA04	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids
ATC	S01BA06	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain
ATC	S01BB04	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids and mydriatics in combination
ATC	S01CA05	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination
ATC	S01CB04	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids/antiinfectives/mydriatics in combination
ATC	S02BA07	SENSORY ORGANS OTOLOGICALS CORTICOSTEROIDS Corticosteroids
ATC	S03BA03	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS CORTICOSTEROIDS Corticosteroids
ATC	S03CA06	SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
CHEBI has role	CHEBI:35472	anti-inflammatory drug
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35705	immunosuppressive agent
CHEBI has role	CHEBI:35845	gout suppressant
CHEBI has role	CHEBI:39456	antiglaucoma drug
CHEBI has role	CHEBI:49201	anti-ulcer drug
CHEBI has role	CHEBI:50177	dermatologic drug
CHEBI has role	CHEBI:50748	antipsoriatic
CHEBI has role	CHEBI:51177	antitussive
CHEBI has role	CHEBI:65023	anti-asthmatic agent
CHEBI has role	CHEBI:66981	ophthalmology drug
CHEBI has role	CHEBI:77715	nasal decongestant
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D019141	Respiratory System Agents

Related Drugs by ATC class:

A07EA Corticosteroids acting locally 6 drugs

beclometasone dipropionate budesonide hydrocortisone prednisolone prednisone tixocortol

C05AA Corticosteroids 8 drugs

dexamethasone fluocinolone acetonide fluocinonide fluocortolone fluorometholone hydrocortisone prednisolone triamcinolone

D07AC Corticosteroids, potent (group III) 20 drugs

amcinonide beclometasone dipropionate budesonide desoximetasone diflorasone diacetate diflucortolone difluprednate fluclorolone fludroxycortide fluocinolone acetonide fluocinonide fluocortolone show all 20 →

D07BC Corticosteroids, potent, combinations with antiseptics 3 drugs

diflucortolone fluocinolone acetonide fluocortolone

D07CC Corticosteroids, potent, combinations with antibiotics 5 drugs

beclometasone dipropionate fludroxycortide fluocinolone acetonide fluocinonide fluocortolone

D07XC Corticosteroids, potent, other combinations 4 drugs

desoximetasone diflucortolone fluocortolone mometasone furoate

H02AB Glucocorticoids 15 drugs

cloprednol cortivazol deflazacort dexamethasone fluocortolone hydrocortisone meprednisone methylprednisolone paramethasone acetate prednisolone prednisone prednylidene show all 15 →

R01AD Corticosteroids 12 drugs

beclometasone dipropionate budesonide ciclesonide dexamethasone flunisolide fluticasone furoate fluticasone propionate hydrocortisone mometasone furoate prednisolone tixocortol triamcinolone

R03BA Glucocorticoids 8 drugs

beclometasone dipropionate budesonide ciclesonide flunisolide fluticasone furoate fluticasone propionate mometasone furoate triamcinolone

S01BA Corticosteroids, plain 15 drugs

alclometasone dipropionate clobetasol propionate clobetasone butyrate desonide dexamethasone difluprednate fluocinolone acetonide fluorometholone formocortal hydrocortisone loteprednol etabonate medrysone show all 15 →

S01BB Corticosteroids and mydriatics in combination 3 drugs

fluorometholone hydrocortisone prednisolone

S01CA Corticosteroids and antiinfectives in combination 11 drugs

chloroprednisone clobetasone butyrate dexamethasone fludrocortisone acetate fluocinolone acetonide fluocortolone fluorometholone hydrocortisone loteprednol etabonate methylprednisolone prednisolone

S01CB Corticosteroids/antiinfectives/mydriatics in combination 4 drugs

dexamethasone fluorometholone hydrocortisone prednisolone

S02BA Corticosteroids 4 drugs

dexamethasone fluocinolone acetonide hydrocortisone prednisolone

S03BA Corticosteroids 2 drugs

dexamethasone prednisolone

S03CA Corticosteroids and antiinfectives in combination 5 drugs

dexamethasone fludrocortisone acetate hydrocortisone methylprednisolone prednisolone

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Disorder of musculoskeletal system	indication	928000	DOID:17
Cerebral edema	indication	2032001
Tinea pedis	indication	6020002	DOID:12403
Berylliosis	indication	8247009	DOID:10322
Psoriasis	indication	9014002	DOID:8893
Ankylosing spondylitis	indication	9631008	DOID:7147
Rheumatic heart disease	indication	23685000
Atopic dermatitis	indication	24079001	DOID:3310
Inflammatory bowel disease	indication	24526004	DOID:0050589
Multiple sclerosis	indication	24700007	DOID:2377
Severe adrenal insufficiency	indication	24867002
Sarcoidosis	indication	31541009	DOID:11335
Idiopathic thrombocytopenic purpura	indication	32273002	DOID:8924
Psoriasis with arthropathy	indication	33339001
Crohn's disease	indication	34000006
Tendinitis	indication	34840004	DOID:971
Erythema multiforme	indication	36715001
Contact dermatitis	indication	40275004	DOID:2773
Angioedema	indication	41291007	DOID:1558
Miliary tuberculosis	indication	47604008	DOID:9861
Humoral hypercalcemia of malignancy	indication	47709007
Articular gout	indication	48440001	DOID:13189
Seborrheic dermatitis	indication	50563003	DOID:8741
Edema of larynx	indication	51599000
Nephrotic syndrome	indication	52254009	DOID:1184
Lichen simplex chronicus	indication	53891004
Systemic lupus erythematosus	indication	55464009	DOID:9074
Allergic rhinitis	indication	61582004
Löffler's syndrome	indication	64936001	DOID:9503
Pemphigus	indication	65172003	DOID:9182
Granuloma annulare	indication	65508009	DOID:3777
Tenosynovitis	indication	67801009	DOID:970
Rheumatoid arthritis	indication	69896004	DOID:7148
Transfusion reaction due to serum protein reaction	indication	72284000
Epicondylitis	indication	73583000	DOID:14087
Acquired thrombocytopenia	indication	74576004	DOID:11126
Thyroiditis	indication	82119001	DOID:7166
Bursitis	indication	84017003	DOID:2965
Tinea corporis	indication	84849002
Autoimmune disease	indication	85828009
Infection by larvae of Trichinella spiralis	indication	88264003
Congenital hypoplastic anemia	indication	88854002	DOID:1339
Pruritus ani	indication	90446007
Acute lymphoid leukemia	indication	91857003	DOID:9952
Disorder of skin	indication	95320005	DOID:37
Dermatitis herpetiformis	indication	111196000	DOID:8505
Hodgkin's disease	indication	118599009
Non-Hodgkin's lymphoma	indication	118601006
Mycosis fungoides	indication	118618005
Aspiration pneumonitis	indication	155597006
Asthma	indication	195967001	DOID:2841
Discoid lupus erythematosus	indication	200938002
Plaque psoriasis	indication	200965009
Transplanted organ rejection	indication	213148006
Congenital adrenal hyperplasia	indication	237751000
Scalp psoriasis	indication	238608008
Adrenogenital disorder	indication	267395000	DOID:0050811
Pruritus of genital organs	indication	267802000
Eruption of skin	indication	271807003	DOID:0050486
Follicular non-Hodgkin's lymphoma	indication	308121000
Disorder of eye	indication	371405004	DOID:5614
Primary adrenocortical insufficiency	indication	373662000
Adrenal cortical hypofunction	indication	386584007	DOID:10493
Tinea cruris	indication	399029005
Erythroderma	indication	399992009
Primary cutaneous T-cell lymphoma	indication	400122007
Dermatosis of scalp	indication	402694007	DOID:3136
Juvenile rheumatoid arthritis	indication	410795001
Autoimmune hemolytic anemia	indication	413603009	DOID:718
Synovitis	indication	416209007	DOID:2703
Post traumatic osteoarthritis	indication	699262001
Systemic Dermatomyositis	indication
Diagnostic Test for Cushing's Syndrome	indication
Erythroblastic Anemia	indication
Synovitis due to Osteoarthritis	indication
Transfusion Reaction Urticaria	indication
Pericarditis	off-label use	3238004	DOID:1787
Chronic obstructive lung disease	off-label use	13645005	DOID:3083
West syndrome	off-label use	28055006
Vasculitis	off-label use	31996006	DOID:865
Bronchitis	off-label use	32398004	DOID:6132
Eczema	off-label use	43116000
Respiratory distress syndrome in the newborn	off-label use	46775006
Nasal polyp	off-label use	52756005
Rheumatic fever	off-label use	58718002	DOID:1586
Pseudogout	off-label use	60782007
Polymyalgia rheumatica	off-label use	65323003	DOID:853
Chronic hepatitis	off-label use	76783007	DOID:2237
Pemphigoid	off-label use	86142006
Hepatic necrosis	off-label use	87248009
Multiple myeloma	off-label use	109989006	DOID:9538
Polyarteritis nodosa	off-label use	155441006	DOID:9810
Celiac disease	off-label use	396331005	DOID:10608
Carditis	off-label use	399617002
Giant cell arteritis	off-label use	414341000	DOID:13375
Hypercalcemia associated with Sarcoidosis	off-label use
Neonatal Bronchopulmonary Dysplasia	off-label use
Infection by Strongyloides	contraindication	1214006	DOID:10955
Mycosis	contraindication	3218000	DOID:1564
Gastritis	contraindication	4556007	DOID:4029
Inactive tuberculosis	contraindication	11999007
Congenital ichthyosis of skin	contraindication	13059002
Peptic ulcer	contraindication	13200003	DOID:750
Hypercholesterolemia	contraindication	13644009
Measles	contraindication	14189004	DOID:8622
Cirrhosis of liver	contraindication	19943007	DOID:5082
Arginase deficiency	contraindication	23501004	DOID:9278
Hypervitaminosis D	contraindication	27712000	DOID:9971
Guttate psoriasis	contraindication	37042000
Immunosuppression	contraindication	38013005
Hypertensive disorder	contraindication	38341003	DOID:10763
Infectious disease	contraindication	40733004
Hypothyroidism	contraindication	40930008	DOID:1459
Hypokalemia	contraindication	43339004
Chronic heart failure	contraindication	48447003
Cerebral malaria	contraindication	53622003	DOID:14069
Tuberculosis	contraindication	56717001
Congenital hyperammonemia, type I	contraindication	62522004
Osteoporosis	contraindication	64859006	DOID:11476
Hypercalcemia	contraindication	66931009	DOID:12678
Psychotic disorder	contraindication	69322001
Disorder of calcium metabolism	contraindication	71638002	DOID:10575
Hypercalciuria	contraindication	71938000
Diabetes mellitus	contraindication	73211009	DOID:9351
Hypopituitarism	contraindication	74728003	DOID:9406
Hyperglycemia	contraindication	80394007	DOID:4195
Ornithine Carbamyltransferase Deficiency	contraindication	80908008	DOID:9271
Open-angle glaucoma	contraindication	84494001	DOID:1067
Muscle atrophy	contraindication	88092000	DOID:767
Herpes simplex	contraindication	88594005	DOID:8566
Bilateral cataracts	contraindication	95722004
Seizure disorder	contraindication	128613002
Disorder of muscle	contraindication	129565002	DOID:423
Ophthalmic herpes simplex	contraindication	186542001
Pustular psoriasis	contraindication	200973000
Anastomosis of intestine	contraindication	235407009
Telangiectasia disorder	contraindication	247479008
Edema	contraindication	267038008
Pathological fracture	contraindication	268029009
Diverticulitis of gastrointestinal tract	contraindication	271366000
Cerebral trauma	contraindication	275382005
Varicella-zoster virus infection	contraindication	309465005
Osteopenia	contraindication	312894000
Avascular necrosis of bone	contraindication	397758007	DOID:10159
Citrullinemia	contraindication	398680004	DOID:9273
Atrophoderma	contraindication	399979006
Peripheral vascular disease	contraindication	400047006
Traumatic rupture of tendon	contraindication	415749005
Exposure to varicella	contraindication	444453009
Arginosuccinate Lyase Deficiency	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.06	acidic
pKa2	12.45	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	IC50	8.07		WOMBAT-PK	CHEMBL
Annexin A1	Cytosolic other	P04083	ANXA1_HUMAN					WOMBAT-PK

External reference:

ID	Source
4018644	VUID
N0000146957	NUI
D00244	KEGG_DRUG
1514	RXNORM
C0005308	UMLSCUI
CHEBI:3077	CHEBI
CHEMBL632	ChEMBL_ID
DB00443	DRUGBANK_ID
7061	IUPHAR_LIGAND_ID
1045	INN_ID
9842X06Q6M	UNII
9782	PUBCHEM_CID
10006	MMSL
4270	MMSL
d00628	MMSL
D001623	MESH_DESCRIPTOR_UI
4018644	VANDF
002168	NDDF
116571008	SNOMEDCT_US
29896003	SNOMEDCT_US
9842X06Q6M	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
DR. THROWERS BETA	HUMAN PRESCRIPTION DRUG LABEL	1	69299-202	OINTMENT	0.05 g	TOPICAL	unapproved drug other	4 sections

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betamethasone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: