betamethasone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 348 378-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betamethasone
  • betadexamethasone
  • betametasone
  • betamethazone
  • bethamethasone
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P
0.40 mg P
0.40 mg N

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.07 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.38 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.36 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 17, 1961 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 976.01 11.71 334 17222 17778 46650728
Premature delivery 856.12 11.71 319 17237 21750 46646756
Exposure during pregnancy 733.37 11.71 473 17083 107739 46560767
Foetal exposure during pregnancy 707.16 11.71 305 17251 30442 46638064
Maternal exposure during pregnancy 667.01 11.71 437 17119 102112 46566394
Low birth weight baby 571.18 11.71 167 17389 5267 46663239
Premature labour 305.76 11.71 126 17430 11173 46657333
Caesarean section 268.32 11.71 129 17427 16474 46652032
Neonatal respiratory distress syndrome 227.59 11.71 69 17487 2464 46666042
Foetal growth restriction 170.07 11.71 71 17485 6496 46662010
Patent ductus arteriosus 139.18 11.71 53 17503 3809 46664697
Psoriasis 133.52 11.71 156 17400 78448 46590058
Pre-eclampsia 119.73 11.71 59 17497 7935 46660571
Live birth 110.96 11.71 61 17495 10269 46658237
Steroid withdrawal syndrome 97.91 11.71 25 17531 466 46668040
Oligohydramnios 92.92 11.71 44 17512 5421 46663085
Premature rupture of membranes 88.91 11.71 40 17516 4383 46664123
Gestational diabetes 86.95 11.71 46 17510 7173 46661333
Ductus arteriosus premature closure 81.19 11.71 20 17536 320 46668186
Computerised tomogram thorax abnormal 80.61 11.71 27 17529 1334 46667172
Bradycardia neonatal 78.28 11.71 22 17534 598 46667908
Maternal drugs affecting foetus 74.60 11.71 38 17518 5480 46663026
Respiratory disorder neonatal 69.53 11.71 22 17534 906 46667600
Selective eating disorder 63.06 11.71 24 17532 1721 46666785
Acute pulmonary oedema 61.90 11.71 38 17518 7853 46660653
Polyhydramnios 56.45 11.71 23 17533 1976 46666530
Cholestasis of pregnancy 53.74 11.71 19 17537 1105 46667401
Atrial septal defect 53.55 11.71 32 17524 6300 46662206
Skin exfoliation 51.93 11.71 63 17493 32875 46635631
Preterm premature rupture of membranes 51.58 11.71 18 17538 1007 46667499
Placental insufficiency 50.61 11.71 19 17537 1312 46667194
Ventricular septal defect 49.41 11.71 26 17530 4008 46664498
Toxic anterior segment syndrome 48.34 11.71 21 17535 2116 46666390
Death 47.84 11.71 34 17522 335514 46332992
Foetal hypokinesia 47.75 11.71 14 17542 444 46668062
Rheumatoid arthritis 46.80 11.71 16 17540 240199 46428307
Hypoxia 45.64 11.71 75 17481 51763 46616743
Weight gain poor 45.33 11.71 15 17541 713 46667793
Bronchopulmonary dysplasia 45.16 11.71 12 17544 263 46668243
Amniotic cavity infection 41.84 11.71 16 17540 1162 46667344
Atelectasis 41.76 11.71 43 17513 18747 46649759
Rectal cancer metastatic 41.05 11.71 11 17545 249 46668257
Ophthalmic herpes simplex 39.75 11.71 11 17545 282 46668224
Foetal heart rate deceleration abnormality 39.05 11.71 12 17544 448 46668058
Cervical incompetence 35.47 11.71 12 17544 611 46667895
Diabetes mellitus inadequate control 34.47 11.71 33 17523 13181 46655325
HELLP syndrome 34.41 11.71 13 17543 913 46667593
Infantile apnoea 32.89 11.71 12 17544 764 46667742
Starvation ketoacidosis 31.72 11.71 7 17549 67 46668439
Foetal disorder 30.50 11.71 9 17547 292 46668214
Fall 30.46 11.71 48 17508 329049 46339457
Neonatal respiratory failure 29.82 11.71 8 17548 182 46668324
Small for dates baby 29.77 11.71 18 17538 3619 46664887
Foetal non-stress test abnormal 29.66 11.71 6 17550 36 46668470
Hydrops foetalis 29.06 11.71 9 17547 345 46668161
Neonatal hypocalcaemia 28.32 11.71 5 17551 12 46668494
Asthenia 28.19 11.71 46 17510 311029 46357477
Hypotonia neonatal 27.88 11.71 11 17545 869 46667637
Foetal distress syndrome 27.32 11.71 12 17544 1241 46667265
Cerebral haemorrhage neonatal 26.81 11.71 7 17549 143 46668363
Pneumocephalus 26.71 11.71 7 17549 145 46668361
Drug intolerance 26.59 11.71 11 17545 147038 46521468
Normal newborn 25.90 11.71 20 17536 5981 46662525
Corneal perforation 25.90 11.71 9 17547 497 46668009
Ulcerative keratitis 25.89 11.71 14 17542 2279 46666227
Umbilical erythema 25.44 11.71 6 17550 79 46668427
Interstitial lung disease 25.39 11.71 60 17496 53889 46614617
Perioral dermatitis 24.91 11.71 6 17550 87 46668419
Twin pregnancy 24.75 11.71 11 17545 1170 46667336
Disseminated intravascular coagulation 24.65 11.71 33 17523 18972 46649534
Death neonatal 23.72 11.71 7 17549 227 46668279
Adrenal suppression 23.67 11.71 10 17546 941 46667565
Gastrointestinal disorder 23.56 11.71 62 17494 59514 46608992
Skin weeping 23.46 11.71 7 17549 236 46668270
Vanishing bile duct syndrome 23.38 11.71 9 17547 665 46667841
Meningitis chemical 22.82 11.71 6 17550 126 46668380
Pneumocystis jirovecii pneumonia 22.15 11.71 28 17528 15220 46653286
Right ventricular dysfunction 22.12 11.71 11 17545 1507 46666999
Cushing's syndrome 22.10 11.71 9 17547 772 46667734
Product use in unapproved indication 21.73 11.71 79 17477 90194 46578312
Pulmonary valve stenosis congenital 21.60 11.71 6 17550 156 46668350
Multiple drug therapy 20.76 11.71 9 17547 902 46667604
Hypoglycaemia neonatal 20.51 11.71 9 17547 929 46667577
Maternal condition affecting foetus 20.50 11.71 6 17550 189 46668317
Foetal growth abnormality 20.39 11.71 4 17552 20 46668486
Pulmonary valve disease 20.39 11.71 4 17552 20 46668486
Skin infection 20.04 11.71 23 17533 11316 46657190
Eczema 19.98 11.71 31 17525 20369 46648137
Cyanosis neonatal 19.87 11.71 6 17550 211 46668295
Toxicity to various agents 19.45 11.71 31 17525 211735 46456771
Hepatic function abnormal 19.24 11.71 41 17515 34380 46634126
Single functional kidney 18.93 11.71 5 17551 107 46668399
Proteinuria 18.86 11.71 27 17529 16526 46651980
Gestational hypertension 18.50 11.71 11 17545 2144 46666362
Angiotensin converting enzyme inhibitor foetopathy 18.35 11.71 4 17552 36 46668470
Delayed delivery 18.25 11.71 4 17552 37 46668469
Pulmonary hypoplasia 18.10 11.71 6 17550 287 46668219
Pulmonary oedema 18.02 11.71 51 17505 51054 46617452
Toxic epidermal necrolysis 17.95 11.71 31 17525 22247 46646259
Retroplacental haematoma 17.42 11.71 5 17551 147 46668359
Ectopic ACTH syndrome 17.37 11.71 3 17553 6 46668500
Intraventricular haemorrhage neonatal 17.26 11.71 5 17551 152 46668354
Diarrhoea 17.05 11.71 132 17424 559470 46109036
Ultrasound uterus abnormal 16.87 11.71 4 17552 54 46668452
Adrenal haematoma 16.76 11.71 3 17553 8 46668498
Apgar score low 16.74 11.71 7 17549 642 46667864
Vomiting 16.66 11.71 101 17455 452693 46215813
Computerised tomogram thorax 16.30 11.71 4 17552 63 46668443
Drug hypersensitivity 16.20 11.71 43 17513 243782 46424724
Scab 16.14 11.71 16 17540 6663 46661843
Skin plaque 16.03 11.71 15 17541 5820 46662686
Arthropathy 15.85 11.71 6 17550 84694 46583812
Adrenal insufficiency 15.83 11.71 22 17534 13102 46655404
Female sex hormone level abnormal 15.29 11.71 3 17553 15 46668491
Blood corticotrophin decreased 15.29 11.71 5 17551 229 46668277
Persistent foetal circulation 15.14 11.71 5 17551 236 46668270
Haemangioma congenital 15.08 11.71 6 17550 484 46668022
Anaemia neonatal 15.02 11.71 5 17551 242 46668264
Fatigue 14.84 11.71 152 17404 608545 46059961
Placenta praevia haemorrhage 14.83 11.71 4 17552 93 46668413
Neonatal hypotension 14.67 11.71 4 17552 97 46668409
Oesophageal atresia 14.65 11.71 6 17550 522 46667984
Tracheo-oesophageal fistula 14.64 11.71 6 17550 523 46667983
Dry gangrene 14.60 11.71 6 17550 527 46667979
Shared psychotic disorder 14.56 11.71 3 17553 20 46668486
Uterine contractions during pregnancy 14.54 11.71 6 17550 532 46667974
Right aortic arch 14.41 11.71 5 17551 275 46668231
Umbilical cord prolapse 14.31 11.71 3 17553 22 46668484
Induced labour 14.30 11.71 7 17549 927 46667579
Ultrasound Doppler abnormal 14.26 11.71 4 17552 108 46668398
ACTH stimulation test abnormal 14.19 11.71 3 17553 23 46668483
Palmoplantar keratoderma 14.15 11.71 4 17552 111 46668395
Confusional state 14.12 11.71 24 17532 159868 46508638
Corneal neovascularisation 14.08 11.71 4 17552 113 46668393
Acute kidney injury 13.91 11.71 44 17512 235811 46432695
Maternal exposure timing unspecified 13.80 11.71 8 17548 1489 46667017
Skin atrophy 13.67 11.71 12 17544 4288 46664218
Infusion related reaction 13.43 11.71 11 17545 101197 46567309
Decreased insulin requirement 13.40 11.71 4 17552 135 46668371
Neonatal disorder 13.39 11.71 6 17550 651 46667855
Neonatal sinus tachycardia 13.39 11.71 3 17553 31 46668475
Umbilical artery vascular resistance increased 13.39 11.71 3 17553 31 46668475
Blood corticotrophin increased 13.14 11.71 3 17553 34 46668472
Neonatal cholestasis 13.06 11.71 3 17553 35 46668471
Bradycardia foetal 12.97 11.71 5 17551 371 46668135
Enlarged clitoris 12.95 11.71 4 17552 152 46668354
Hypothalamic pituitary adrenal axis suppression 12.70 11.71 4 17552 162 46668344
Hypopituitarism 12.67 11.71 6 17550 739 46667767
Haemoperitoneum 12.33 11.71 9 17547 2473 46666033
Neonatal anuria 12.18 11.71 3 17553 48 46668458
Stevens-Johnson syndrome 12.16 11.71 27 17529 23270 46645236
Memory impairment 12.13 11.71 7 17549 77330 46591176
Pain 12.06 11.71 118 17438 476830 46191676
Systolic dysfunction 12.05 11.71 7 17549 1307 46667199
Respiratory alkalosis 11.99 11.71 9 17547 2582 46665924
Hypotension 11.95 11.71 46 17510 232543 46435963
Haematopoietic neoplasm 11.95 11.71 3 17553 52 46668454
Jaundice neonatal 11.83 11.71 6 17550 857 46667649
Cytomegalovirus enteritis 11.82 11.71 4 17552 204 46668302
Aplastic anaemia 11.79 11.71 14 17542 7139 46661367
Neonatal hypoxia 11.77 11.71 5 17551 477 46668029
Injection site exfoliation 11.76 11.71 4 17552 207 46668299

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 755.08 14.34 272 11311 16419 29924476
Foetal exposure during pregnancy 634.82 14.34 301 11282 36570 29904325
Low birth weight baby 406.89 14.34 133 11450 5943 29934952
Drug eruption 319.12 14.34 149 11434 17377 29923518
Hepatic function abnormal 263.35 14.34 177 11406 41768 29899127
Stomatitis 207.19 14.34 146 11437 37133 29903762
Urticaria 198.31 14.34 166 11417 54440 29886455
Hypersensitivity 187.45 14.34 160 11423 53868 29887027
Patent ductus arteriosus 163.22 14.34 57 11526 3112 29937783
Epistaxis 155.99 14.34 143 11440 52838 29888057
Muscle spasms 142.28 14.34 149 11434 64689 29876206
Pain in extremity 122.74 14.34 180 11403 110041 29830854
Atrial septal defect 112.69 14.34 54 11529 6647 29934248
Neonatal respiratory distress syndrome 104.81 14.34 44 11539 3968 29936927
Psoriasis 104.63 14.34 104 11479 42402 29898493
Foetal growth restriction 89.26 14.34 38 11545 3547 29937348
Appendicolith 69.14 14.34 22 11561 897 29939998
Caesarean section 57.70 14.34 24 11559 2113 29938782
Toxicity to various agents 50.61 14.34 5 11578 177178 29763717
Maternal drugs affecting foetus 44.59 14.34 25 11558 4248 29936647
Septum pellucidum agenesis 43.79 14.34 8 11575 24 29940871
Drug ineffective 42.61 14.34 250 11333 340137 29600758
Steroid withdrawal syndrome 42.43 14.34 11 11572 212 29940683
Apgar score low 42.06 14.34 15 11568 870 29940025
Appendicitis 41.02 14.34 27 11556 6117 29934778
Death 40.85 14.34 47 11536 357236 29583659
Respiratory disorder neonatal 37.76 14.34 15 11568 1173 29939722
Pneumonia 36.43 14.34 237 11346 334069 29606826
Maternal exposure during pregnancy 35.98 14.34 21 11562 3850 29937045
Hydrops foetalis 35.73 14.34 10 11573 260 29940635
Skin erosion 32.14 14.34 15 11568 1738 29939157
Polydipsia 32 14.34 19 11564 3594 29937301
Foetal heart rate deceleration abnormality 31.18 14.34 10 11573 418 29940477
Congenital hearing disorder 28.96 14.34 7 11576 100 29940795
Perioral dermatitis 28.46 14.34 7 11576 108 29940787
Congenital cystic lung 27.85 14.34 8 11575 229 29940666
Polyhydramnios 27.65 14.34 8 11575 235 29940660
Ventricular septal defect 27.25 14.34 17 11566 3512 29937383
Persistent corneal epithelial defect 26.25 14.34 5 11578 20 29940875
Anaplastic astrocytoma 25.95 14.34 7 11576 158 29940737
Ulcerative keratitis 25.82 14.34 12 11571 1377 29939518
Neonatal cholestasis 24.87 14.34 5 11578 28 29940867
Corneal opacity 24.47 14.34 9 11574 570 29940325
Ciliary hyperaemia 24.43 14.34 5 11578 31 29940864
Corneal oedema 23.35 14.34 11 11572 1301 29939594
Craniosynostosis 23.30 14.34 7 11576 235 29940660
Transient aphasia 23.22 14.34 6 11577 114 29940781
Enterocolitis bacterial 23.10 14.34 7 11576 242 29940653
Epididymitis 22.66 14.34 13 11570 2306 29938589
Trisomy 21 22.51 14.34 8 11575 459 29940436
Skin indentation 21.89 14.34 4 11579 12 29940883
Drug abuse 21.70 14.34 3 11580 82069 29858826
Haemangioma congenital 21.58 14.34 8 11575 518 29940377
Shared psychotic disorder 21.21 14.34 4 11579 15 29940880
Neonatal respiratory failure 21.18 14.34 7 11576 322 29940573
Tachycardia foetal 21.14 14.34 7 11576 324 29940571
Adrenal insufficiency 21.03 14.34 23 11560 10440 29930455
Large for dates baby 20.92 14.34 9 11574 861 29940034
Stress 20.92 14.34 32 11551 20203 29920692
Cryptorchism 20.79 14.34 11 11572 1666 29939229
Guttate psoriasis 20.65 14.34 6 11577 179 29940716
Hypertrophic cardiomyopathy 20.31 14.34 9 11574 924 29939971
Congenital pulmonary valve atresia 20.28 14.34 5 11578 78 29940817
Dermatitis acneiform 19.97 14.34 17 11566 5672 29935223
Pyelocaliectasis 19.57 14.34 9 11574 1008 29939887
Necrotising enterocolitis neonatal 18.92 14.34 5 11578 104 29940791
Scab 18.82 14.34 14 11569 3852 29937043
Small for dates baby 18.79 14.34 13 11570 3195 29937700
Glioblastoma 18.26 14.34 9 11574 1176 29939719
Glucocorticoid deficiency 18.12 14.34 6 11577 278 29940617
Bronchopulmonary dysplasia 18.01 14.34 7 11576 516 29940379
Selective eating disorder 17.97 14.34 10 11573 1674 29939221
Vesicoureteric reflux 17.51 14.34 5 11578 140 29940755
Vertical infection transmission 17.28 14.34 3 11580 6 29940889
Fatigue 17.17 14.34 65 11518 320608 29620287
Rickets 16.83 14.34 4 11579 53 29940842
Congenital herpes simplex infection 16.69 14.34 4 11579 55 29940840
Death neonatal 16.61 14.34 6 11577 361 29940534
Acarodermatitis 16.59 14.34 6 11577 362 29940533
Necrotising scleritis 16.18 14.34 3 11580 10 29940885
Microphthalmos 15.80 14.34 5 11578 200 29940695
Hypothalamic pituitary adrenal axis suppression 15.57 14.34 5 11578 210 29940685
Congenital brain damage 15.21 14.34 3 11580 15 29940880
Keratitis fungal 15.19 14.34 4 11579 82 29940813
Cardiogenic shock 15.13 14.34 25 11558 16836 29924059
Cerebral ventricle dilatation 15.13 14.34 7 11576 795 29940100
Laryngeal cleft 14.89 14.34 3 11580 17 29940878
Exposure during pregnancy 14.65 14.34 18 11565 9243 29931652
Phaeochromocytoma crisis 14.47 14.34 3 11580 20 29940875
Arthritis allergic 14.35 14.34 3 11580 21 29940874

Pharmacologic Action:

SourceCodeDescription
ATC A07EA04 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC C05AA05 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07XC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, potent, other combinations
ATC H02AB01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD06 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03BA04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
ATC S01BA06 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA07 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S03BA03 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC D07BC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, potent, combinations with antiseptics
ATC D07CC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
ATC S01BB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids and mydriatics in combination
ATC S01CA05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03CA06 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35705 immunosuppressant
CHEBI has role CHEBI:65023 antiasthmatic agent
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D019141 Respiratory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Tinea pedis indication 6020002 DOID:12403
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Tinea corporis indication 84849002
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Tinea cruris indication 399029005
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Dermatosis of scalp indication 402694007 DOID:3136
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Systemic Dermatomyositis indication
Diagnostic Test for Cushing's Syndrome indication
Erythroblastic Anemia indication
Synovitis due to Osteoarthritis indication
Transfusion Reaction Urticaria indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Hypercalcemia associated with Sarcoidosis off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Congenital ichthyosis of skin contraindication 13059002
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Hypervitaminosis D contraindication 27712000 DOID:9971
Guttate psoriasis contraindication 37042000
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Hypercalcemia contraindication 66931009 DOID:12678
Psychotic disorder contraindication 69322001
Disorder of calcium metabolism contraindication 71638002 DOID:10575
Hypercalciuria contraindication 71938000
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Pustular psoriasis contraindication 200973000
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST IC50 8.07 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

IDSource
9842X06Q6M UNII
4018644 VUID
N0000146957 NUI
D00244 KEGG_DRUG
4018644 VANDF
C0005308 UMLSCUI
CHEBI:3077 CHEBI
CHEMBL632 ChEMBL_ID
DB00443 DRUGBANK_ID
D001623 MESH_DESCRIPTOR_UI
1045 INN_ID
9782 PUBCHEM_CID
7061 IUPHAR_LIGAND_ID
1514 RXNORM
10006 MMSL
4270 MMSL
d00628 MMSL
002168 NDDF
116571008 SNOMEDCT_US
29896003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DR. THROWERS BETA HUMAN PRESCRIPTION DRUG LABEL 1 69299-202 OINTMENT 0.05 g TOPICAL unapproved drug other 4 sections