Stem definition | Drug id | CAS RN |
---|---|---|
corticosteroids, except prednisolone derivatives | 1388 | 50-23-7 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
30 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.42 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 353.81 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.38 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 5.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.20 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 27, 2021 | EMA | Diurnal Europe B.V. | |
Aug. 5, 1952 | FDA | MERCK |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Infusion related reaction | 415.67 | 9.42 | 1131 | 141634 | 154826 | 53051475 |
Completed suicide | 327.85 | 9.42 | 9 | 142756 | 138192 | 53068109 |
Adrenocortical insufficiency acute | 311.27 | 9.42 | 126 | 142639 | 1387 | 53204914 |
Anti-cyclic citrullinated peptide antibody positive | 288.25 | 9.42 | 535 | 142230 | 56637 | 53149664 |
Pericarditis | 270.42 | 9.42 | 558 | 142207 | 63848 | 53142453 |
Adrenal insufficiency | 266.71 | 9.42 | 259 | 142506 | 14570 | 53191731 |
Rheumatoid factor positive | 240.38 | 9.42 | 411 | 142354 | 40787 | 53165514 |
Drug hypersensitivity | 238.26 | 9.42 | 1364 | 141401 | 263878 | 52942423 |
Wound | 229.77 | 9.42 | 650 | 142115 | 90907 | 53115394 |
Discomfort | 216.76 | 9.42 | 654 | 142111 | 94818 | 53111483 |
Hand deformity | 206.69 | 9.42 | 596 | 142169 | 84253 | 53122048 |
Toxicity to various agents | 192.91 | 9.42 | 182 | 142583 | 219416 | 52986885 |
Steroid withdrawal syndrome | 176.58 | 9.42 | 64 | 142701 | 507 | 53205794 |
Synovitis | 172.39 | 9.42 | 657 | 142108 | 107236 | 53099065 |
Glossodynia | 171.32 | 9.42 | 624 | 142141 | 99667 | 53106634 |
Death | 168.57 | 9.42 | 449 | 142316 | 356783 | 52849518 |
Duodenal ulcer perforation | 152.54 | 9.42 | 309 | 142456 | 34874 | 53171427 |
Pemphigus | 145.71 | 9.42 | 608 | 142157 | 103423 | 53102878 |
Intentional product use issue | 139.28 | 9.42 | 469 | 142296 | 72025 | 53134276 |
Helicobacter infection | 137.12 | 9.42 | 315 | 142450 | 38754 | 53167547 |
Hypersensitivity | 132.99 | 9.42 | 992 | 141773 | 209673 | 52996628 |
Drug abuse | 131.26 | 9.42 | 12 | 142753 | 65514 | 53140787 |
Systemic lupus erythematosus | 129.88 | 9.42 | 671 | 142094 | 124743 | 53081558 |
Arthropathy | 127.73 | 9.42 | 729 | 142036 | 140724 | 53065577 |
Hepatic enzyme increased | 124.38 | 9.42 | 666 | 142099 | 125529 | 53080772 |
Product use issue | 116.73 | 9.42 | 705 | 142060 | 138879 | 53067422 |
Colitis ulcerative | 116.14 | 9.42 | 205 | 142560 | 20856 | 53185445 |
Intentional overdose | 101.73 | 9.42 | 27 | 142738 | 67178 | 53139123 |
Swelling | 99.88 | 9.42 | 862 | 141903 | 190243 | 53016058 |
Febrile bone marrow aplasia | 99.32 | 9.42 | 109 | 142656 | 7080 | 53199221 |
Overdose | 98.42 | 9.42 | 86 | 142679 | 107650 | 53098651 |
Craniopharyngioma | 97.73 | 9.42 | 30 | 142735 | 131 | 53206170 |
Fall | 87.93 | 9.42 | 580 | 142185 | 357860 | 52848441 |
Blood pressure fluctuation | 86.14 | 9.42 | 249 | 142516 | 35221 | 53171080 |
Drug interaction | 80.61 | 9.42 | 308 | 142457 | 219021 | 52987280 |
Hypofibrinogenaemia | 80.57 | 9.42 | 46 | 142719 | 1129 | 53205172 |
Abdominal discomfort | 79.10 | 9.42 | 922 | 141843 | 220140 | 52986161 |
Drug intolerance | 78.00 | 9.42 | 867 | 141898 | 204626 | 53001675 |
Secondary adrenocortical insufficiency | 77.38 | 9.42 | 46 | 142719 | 1220 | 53205081 |
Condition aggravated | 77.15 | 9.42 | 1169 | 141596 | 295965 | 52910336 |
Alopecia | 75.51 | 9.42 | 959 | 141806 | 233624 | 52972677 |
Rash | 73.61 | 9.42 | 1635 | 141130 | 444556 | 52761745 |
Pituitary tumour benign | 71.18 | 9.42 | 51 | 142714 | 1870 | 53204431 |
Maternal exposure during pregnancy | 59.16 | 9.42 | 657 | 142108 | 154982 | 53051319 |
Blister | 59.06 | 9.42 | 387 | 142378 | 78366 | 53127935 |
Product dose omission issue | 58.24 | 9.42 | 289 | 142476 | 191331 | 53014970 |
Rheumatic fever | 56.17 | 9.42 | 112 | 142653 | 12492 | 53193809 |
Suicide attempt | 53.63 | 9.42 | 46 | 142719 | 58122 | 53148179 |
Device expulsion | 53.40 | 9.42 | 8 | 142757 | 29805 | 53176496 |
Cardiac failure congestive | 52.96 | 9.42 | 105 | 142660 | 92652 | 53113649 |
Hip arthroplasty | 52.36 | 9.42 | 179 | 142586 | 27683 | 53178618 |
Acute kidney injury | 50.65 | 9.42 | 435 | 142330 | 253433 | 52952868 |
Urticaria thermal | 46.76 | 9.42 | 17 | 142748 | 136 | 53206165 |
Frequent bowel movements | 45.99 | 9.42 | 112 | 142653 | 14300 | 53192001 |
Adrenal suppression | 45.96 | 9.42 | 30 | 142735 | 942 | 53205359 |
Cerebrovascular accident | 45.89 | 9.42 | 137 | 142628 | 105037 | 53101264 |
Female genital tract fistula | 45.09 | 9.42 | 55 | 142710 | 4003 | 53202298 |
Cortisol decreased | 44.40 | 9.42 | 31 | 142734 | 1090 | 53205211 |
Hyperadrenocorticism | 44.19 | 9.42 | 21 | 142744 | 348 | 53205953 |
Swollen joint count increased | 44.06 | 9.42 | 95 | 142670 | 11195 | 53195106 |
Joint swelling | 43.81 | 9.42 | 876 | 141889 | 233762 | 52972539 |
Hypopituitarism | 41.91 | 9.42 | 28 | 142737 | 915 | 53205386 |
Knee arthroplasty | 40.70 | 9.42 | 188 | 142577 | 33381 | 53172920 |
Hypothalamic pituitary adrenal axis suppression | 38.41 | 9.42 | 15 | 142750 | 149 | 53206152 |
Musculoskeletal injury | 37.87 | 9.42 | 14 | 142751 | 118 | 53206183 |
Heart rate irregular | 37.47 | 9.42 | 130 | 142635 | 20254 | 53186047 |
Poor venous access | 36.73 | 9.42 | 82 | 142683 | 9893 | 53196408 |
Colitis | 36.68 | 9.42 | 213 | 142552 | 41339 | 53164962 |
Cardiac failure | 36.60 | 9.42 | 113 | 142652 | 85731 | 53120570 |
Anaemia | 36.50 | 9.42 | 521 | 142244 | 276197 | 52930104 |
Hypothalamo-pituitary disorder | 35.13 | 9.42 | 23 | 142742 | 726 | 53205575 |
Intentional self-injury | 34.92 | 9.42 | 12 | 142753 | 25272 | 53181029 |
Sedation | 34.71 | 9.42 | 18 | 142747 | 29657 | 53176644 |
Off label use | 34.34 | 9.42 | 1568 | 141197 | 470644 | 52735657 |
Drug level below therapeutic | 34.24 | 9.42 | 46 | 142719 | 3687 | 53202614 |
Respiratory arrest | 34.11 | 9.42 | 24 | 142741 | 33516 | 53172785 |
Serotonin syndrome | 34.01 | 9.42 | 14 | 142751 | 26392 | 53179909 |
Neoplasm recurrence | 33.54 | 9.42 | 37 | 142728 | 2417 | 53203884 |
Contraindicated product administered | 33.33 | 9.42 | 529 | 142236 | 135100 | 53071201 |
Perioral dermatitis | 33.11 | 9.42 | 12 | 142753 | 95 | 53206206 |
Irritable bowel syndrome | 33.05 | 9.42 | 215 | 142550 | 43417 | 53162884 |
Nausea | 32.69 | 9.42 | 1673 | 141092 | 754418 | 52451883 |
Insulin-like growth factor increased | 32.32 | 9.42 | 23 | 142742 | 834 | 53205467 |
Eczema | 32 | 9.42 | 139 | 142626 | 24043 | 53182258 |
Muscle injury | 31.97 | 9.42 | 161 | 142604 | 29605 | 53176696 |
Coma | 31.88 | 9.42 | 74 | 142691 | 61709 | 53144592 |
Renal impairment | 31.87 | 9.42 | 115 | 142650 | 83203 | 53123098 |
Syncope | 31.69 | 9.42 | 173 | 142592 | 111820 | 53094481 |
Cardio-respiratory arrest | 31.43 | 9.42 | 69 | 142696 | 58689 | 53147612 |
Inappropriate schedule of product administration | 31.17 | 9.42 | 322 | 142443 | 74556 | 53131745 |
Faecal calprotectin increased | 30.94 | 9.42 | 33 | 142732 | 2075 | 53204226 |
Tendonitis | 30.86 | 9.42 | 108 | 142657 | 16898 | 53189403 |
Breast cancer | 30.71 | 9.42 | 53 | 142712 | 49305 | 53156996 |
Human bocavirus infection | 30.65 | 9.42 | 16 | 142749 | 327 | 53205974 |
Interstitial lung disease | 30.42 | 9.42 | 70 | 142695 | 58552 | 53147749 |
Sleep disorder due to general medical condition, insomnia type | 29.99 | 9.42 | 137 | 142628 | 24212 | 53182089 |
Malignant neoplasm progression | 29.91 | 9.42 | 95 | 142670 | 71446 | 53134855 |
Myocardial infarction | 29.49 | 9.42 | 151 | 142614 | 99203 | 53107098 |
Chronic obstructive pulmonary disease | 29.27 | 9.42 | 76 | 142689 | 60997 | 53145304 |
Injury | 28.73 | 9.42 | 234 | 142531 | 50737 | 53155564 |
Type 2 diabetes mellitus | 28.38 | 9.42 | 163 | 142602 | 31507 | 53174794 |
Asphyxia | 28.19 | 9.42 | 54 | 142711 | 5847 | 53200454 |
Hypophysitis | 28.18 | 9.42 | 28 | 142737 | 1619 | 53204682 |
Electrocardiogram QT prolonged | 27.95 | 9.42 | 69 | 142696 | 56334 | 53149967 |
Cognitive disorder | 27.93 | 9.42 | 48 | 142717 | 44730 | 53161571 |
Blood creatinine increased | 27.85 | 9.42 | 120 | 142645 | 82542 | 53123759 |
Salpingo-oophorectomy unilateral | 27.75 | 9.42 | 19 | 142746 | 647 | 53205654 |
Folliculitis | 27.63 | 9.42 | 162 | 142603 | 31547 | 53174754 |
Insulin-like growth factor decreased | 27.30 | 9.42 | 16 | 142749 | 413 | 53205888 |
Drug withdrawal syndrome | 27.27 | 9.42 | 21 | 142744 | 28001 | 53178300 |
Therapeutic response shortened | 27.20 | 9.42 | 59 | 142706 | 6980 | 53199321 |
Wrong technique in product usage process | 27.05 | 9.42 | 77 | 142688 | 59955 | 53146346 |
Haemoglobin decreased | 27.02 | 9.42 | 236 | 142529 | 137071 | 53069230 |
Plasma cell myeloma | 26.63 | 9.42 | 55 | 142710 | 47819 | 53158482 |
Hospitalisation | 26.51 | 9.42 | 99 | 142666 | 70913 | 53135388 |
Body temperature fluctuation | 26.33 | 9.42 | 30 | 142735 | 2031 | 53204270 |
Gastrointestinal haemorrhage | 26.22 | 9.42 | 118 | 142647 | 80212 | 53126089 |
Atrial fibrillation | 26.12 | 9.42 | 183 | 142582 | 111469 | 53094832 |
Lactic acidosis | 26.03 | 9.42 | 37 | 142728 | 37216 | 53169085 |
Arthralgia | 25.88 | 9.42 | 1431 | 141334 | 438352 | 52767949 |
Drug tolerance decreased | 25.44 | 9.42 | 59 | 142706 | 7299 | 53199002 |
Urticaria | 24.88 | 9.42 | 506 | 142259 | 135379 | 53070922 |
Natural killer-cell leukaemia | 24.47 | 9.42 | 10 | 142755 | 113 | 53206188 |
Tendon pain | 24.37 | 9.42 | 36 | 142729 | 3152 | 53203149 |
Adrenal disorder | 24.19 | 9.42 | 24 | 142741 | 1385 | 53204916 |
Suicidal ideation | 24.16 | 9.42 | 82 | 142683 | 60429 | 53145872 |
Antithrombin III | 23.84 | 9.42 | 11 | 142754 | 170 | 53206131 |
Haematochezia | 23.62 | 9.42 | 194 | 142571 | 42164 | 53164137 |
Injection site reaction | 23.51 | 9.42 | 65 | 142700 | 51101 | 53155200 |
Disease progression | 23.38 | 9.42 | 168 | 142597 | 101752 | 53104549 |
Allergy test positive | 23.23 | 9.42 | 14 | 142751 | 381 | 53205920 |
Tendon rupture | 23.13 | 9.42 | 60 | 142705 | 7964 | 53198337 |
Mucous stools | 22.88 | 9.42 | 34 | 142731 | 2992 | 53203309 |
Anal fistula | 22.61 | 9.42 | 33 | 142732 | 2858 | 53203443 |
Platelet count decreased | 22.52 | 9.42 | 183 | 142582 | 107916 | 53098385 |
Intentional product misuse | 22.51 | 9.42 | 63 | 142702 | 49329 | 53156972 |
Faecal volume decreased | 22.43 | 9.42 | 11 | 142754 | 196 | 53206105 |
Septic shock | 22.39 | 9.42 | 260 | 142505 | 61969 | 53144332 |
Metastases to bone | 22.20 | 9.42 | 12 | 142753 | 19316 | 53186985 |
Blood creatine phosphokinase increased | 22.08 | 9.42 | 27 | 142738 | 28958 | 53177343 |
Skin weeping | 21.86 | 9.42 | 13 | 142752 | 345 | 53205956 |
Normal tension glaucoma | 21.58 | 9.42 | 8 | 142757 | 68 | 53206233 |
Blood count abnormal | 21.38 | 9.42 | 14 | 142751 | 20301 | 53186000 |
Anal abscess | 21.35 | 9.42 | 38 | 142727 | 3890 | 53202411 |
Injection site swelling | 21.24 | 9.42 | 52 | 142713 | 42576 | 53163725 |
Airway peak pressure increased | 21.22 | 9.42 | 12 | 142753 | 289 | 53206012 |
Proctalgia | 21.17 | 9.42 | 45 | 142720 | 5251 | 53201050 |
Bradycardia | 21.08 | 9.42 | 108 | 142657 | 70948 | 53135353 |
Product quality issue | 21.04 | 9.42 | 42 | 142723 | 36981 | 53169320 |
Pulmonary arterial hypertension | 20.94 | 9.42 | 25 | 142740 | 27097 | 53179204 |
Depressed level of consciousness | 20.89 | 9.42 | 75 | 142690 | 54353 | 53151948 |
Erythrodermic psoriasis | 20.76 | 9.42 | 19 | 142746 | 991 | 53205310 |
Somnolence | 20.64 | 9.42 | 320 | 142445 | 167414 | 53038887 |
Diaphragm muscle weakness | 20.59 | 9.42 | 6 | 142759 | 21 | 53206280 |
Gastroenteritis norovirus | 20.50 | 9.42 | 24 | 142741 | 1673 | 53204628 |
Eczema herpeticum | 20.36 | 9.42 | 9 | 142756 | 125 | 53206176 |
Hepatic function abnormal | 20.01 | 9.42 | 43 | 142722 | 36856 | 53169445 |
Clostridium difficile colitis | 19.90 | 9.42 | 105 | 142660 | 19660 | 53186641 |
Injection site erythema | 19.89 | 9.42 | 123 | 142642 | 77126 | 53129175 |
Neuroleptic malignant syndrome | 19.86 | 9.42 | 4 | 142761 | 12029 | 53194272 |
Anal fissure | 19.84 | 9.42 | 32 | 142733 | 3024 | 53203277 |
Meningitis candida | 19.70 | 9.42 | 7 | 142758 | 52 | 53206249 |
Oedema peripheral | 19.62 | 9.42 | 330 | 142435 | 170457 | 53035844 |
Fistula | 19.38 | 9.42 | 60 | 142705 | 8810 | 53197491 |
Labelled drug-drug interaction medication error | 19.35 | 9.42 | 3 | 142762 | 10896 | 53195405 |
Secondary immunodeficiency | 19.16 | 9.42 | 19 | 142746 | 1096 | 53205205 |
Perfume sensitivity | 18.88 | 9.42 | 15 | 142750 | 644 | 53205657 |
Drug level decreased | 18.86 | 9.42 | 50 | 142715 | 6724 | 53199577 |
Loss of consciousness | 18.80 | 9.42 | 205 | 142560 | 114007 | 53092294 |
Treatment failure | 18.74 | 9.42 | 463 | 142302 | 127940 | 53078361 |
Acute myocardial infarction | 18.63 | 9.42 | 38 | 142727 | 33197 | 53173104 |
Blood cholesterol increased | 18.45 | 9.42 | 220 | 142545 | 52769 | 53153532 |
Arteriosclerosis coronary artery | 18.30 | 9.42 | 57 | 142708 | 8397 | 53197904 |
Accidental exposure to product | 18.09 | 9.42 | 22 | 142743 | 23652 | 53182649 |
Pituitary tumour recurrent | 17.71 | 9.42 | 7 | 142758 | 72 | 53206229 |
Therapy cessation | 17.52 | 9.42 | 30 | 142735 | 27995 | 53178306 |
Febrile neutropenia | 17.34 | 9.42 | 385 | 142380 | 104551 | 53101750 |
Wheezing | 17.33 | 9.42 | 258 | 142507 | 65017 | 53141284 |
Enterococcal sepsis | 17.32 | 9.42 | 20 | 142745 | 1374 | 53204927 |
Abdominal pain | 17.30 | 9.42 | 844 | 141921 | 255059 | 52951242 |
Cerebral microangiopathy | 17.28 | 9.42 | 10 | 142755 | 252 | 53206049 |
Sinusitis fungal | 17.27 | 9.42 | 20 | 142745 | 1378 | 53204923 |
Rhabdomyolysis | 17.21 | 9.42 | 60 | 142705 | 43863 | 53162438 |
B-lymphocyte count increased | 17.20 | 9.42 | 8 | 142757 | 126 | 53206175 |
Natural killer cell count decreased | 17.07 | 9.42 | 6 | 142759 | 43 | 53206258 |
Leukoencephalopathy | 17.01 | 9.42 | 36 | 142729 | 4188 | 53202113 |
Vaginal flatulence | 16.96 | 9.42 | 10 | 142755 | 261 | 53206040 |
White blood cell count decreased | 16.86 | 9.42 | 233 | 142532 | 124242 | 53082059 |
Excessive eye blinking | 16.72 | 9.42 | 16 | 142749 | 883 | 53205418 |
Diabetes insipidus | 16.64 | 9.42 | 27 | 142738 | 2564 | 53203737 |
Skin fragility | 16.64 | 9.42 | 14 | 142751 | 652 | 53205649 |
Melaena | 16.59 | 9.42 | 33 | 142732 | 29096 | 53177205 |
Vaginal discharge | 16.57 | 9.42 | 43 | 142722 | 5710 | 53200591 |
Tuberculosis gastrointestinal | 16.50 | 9.42 | 11 | 142754 | 358 | 53205943 |
Neutropenic infection | 16.40 | 9.42 | 18 | 142747 | 1169 | 53205132 |
Dry skin | 16.38 | 9.42 | 191 | 142574 | 45569 | 53160732 |
Mastocytosis | 16.35 | 9.42 | 12 | 142753 | 457 | 53205844 |
Lupus vulgaris | 16.30 | 9.42 | 13 | 142752 | 561 | 53205740 |
Cardiac arrest | 16.27 | 9.42 | 166 | 142599 | 93501 | 53112800 |
Neutropenia | 16.26 | 9.42 | 314 | 142451 | 158871 | 53047430 |
Balance disorder | 16.14 | 9.42 | 122 | 142643 | 73085 | 53133216 |
Abortion spontaneous | 16.14 | 9.42 | 67 | 142698 | 46568 | 53159733 |
Diarrhoea haemorrhagic | 16.11 | 9.42 | 54 | 142711 | 8266 | 53198035 |
Tendon disorder | 16.10 | 9.42 | 42 | 142723 | 5593 | 53200708 |
Drug level above therapeutic | 16.09 | 9.42 | 34 | 142731 | 3950 | 53202351 |
Drug specific antibody present | 15.99 | 9.42 | 31 | 142734 | 3387 | 53202914 |
Live birth | 15.85 | 9.42 | 81 | 142684 | 14978 | 53191323 |
Weight increased | 15.84 | 9.42 | 684 | 142081 | 203883 | 53002418 |
Schizophrenia | 15.80 | 9.42 | 4 | 142761 | 10275 | 53196026 |
Tremor | 15.76 | 9.42 | 239 | 142526 | 125497 | 53080804 |
Hypogonadism | 15.73 | 9.42 | 7 | 142758 | 99 | 53206202 |
Femur fracture | 15.56 | 9.42 | 54 | 142711 | 39531 | 53166770 |
Cardiac disorder | 15.32 | 9.42 | 69 | 142696 | 46897 | 53159404 |
Sputum increased | 15.24 | 9.42 | 24 | 142741 | 2222 | 53204079 |
Macular degeneration | 15.21 | 9.42 | 7 | 142758 | 12354 | 53193947 |
Injection site pain | 15.09 | 9.42 | 213 | 142552 | 113178 | 53093123 |
Pneumonia | 15.09 | 9.42 | 914 | 141851 | 406255 | 52800046 |
Red blood cell sedimentation rate abnormal | 14.96 | 9.42 | 12 | 142753 | 15677 | 53190624 |
Glomerulonephritis chronic | 14.80 | 9.42 | 8 | 142757 | 176 | 53206125 |
CSF lymphocyte count abnormal | 14.78 | 9.42 | 3 | 142762 | 0 | 53206301 |
Thyroid stimulating immunoglobulin increased | 14.73 | 9.42 | 7 | 142758 | 116 | 53206185 |
Complication associated with device | 14.63 | 9.42 | 13 | 142752 | 16152 | 53190149 |
Rhinovirus infection | 14.49 | 9.42 | 32 | 142733 | 3833 | 53202468 |
Pyoderma gangrenosum | 14.36 | 9.42 | 28 | 142737 | 3071 | 53203230 |
Accidental overdose | 14.36 | 9.42 | 22 | 142743 | 21457 | 53184844 |
Orthostatic hypotension | 14.27 | 9.42 | 37 | 142728 | 29716 | 53176585 |
Unevaluable event | 14.25 | 9.42 | 76 | 142689 | 49422 | 53156879 |
Dyskinesia | 14.21 | 9.42 | 41 | 142724 | 31792 | 53174509 |
Pseudostroke | 14.19 | 9.42 | 4 | 142761 | 12 | 53206289 |
Deep vein thrombosis postoperative | 14.12 | 9.42 | 16 | 142749 | 1077 | 53205224 |
Product prescribing error | 14.08 | 9.42 | 25 | 142740 | 23006 | 53183295 |
Fibromyalgia | 14.05 | 9.42 | 180 | 142585 | 43895 | 53162406 |
Medication error | 14.03 | 9.42 | 50 | 142715 | 36315 | 53169986 |
Rectal abscess | 13.98 | 9.42 | 16 | 142749 | 1088 | 53205213 |
Nasal polyps | 13.93 | 9.42 | 27 | 142738 | 2949 | 53203352 |
Hepatotoxicity | 13.89 | 9.42 | 34 | 142731 | 27846 | 53178455 |
Ascites | 13.80 | 9.42 | 57 | 142708 | 39678 | 53166623 |
Excessive skin | 13.78 | 9.42 | 7 | 142758 | 135 | 53206166 |
Cerebral vasoconstriction | 13.76 | 9.42 | 16 | 142749 | 1107 | 53205194 |
Osteonecrosis of jaw | 13.74 | 9.42 | 50 | 142715 | 36096 | 53170205 |
PO2 decreased | 13.71 | 9.42 | 19 | 142746 | 1568 | 53204733 |
Candida infection | 13.69 | 9.42 | 115 | 142650 | 25158 | 53181143 |
Increased bronchial secretion | 13.61 | 9.42 | 20 | 142745 | 1743 | 53204558 |
Dysarthria | 13.59 | 9.42 | 59 | 142706 | 40509 | 53165792 |
Vertigo | 13.56 | 9.42 | 91 | 142674 | 55990 | 53150311 |
Hyperemesis gravidarum | 13.54 | 9.42 | 12 | 142753 | 600 | 53205701 |
Neutropenic sepsis | 13.52 | 9.42 | 76 | 142689 | 14573 | 53191728 |
Hepatic cirrhosis | 13.51 | 9.42 | 17 | 142748 | 18005 | 53188296 |
Hepatitis | 13.48 | 9.42 | 46 | 142719 | 33848 | 53172453 |
Therapeutic product effect incomplete | 13.45 | 9.42 | 169 | 142596 | 91615 | 53114686 |
Pituitary haemorrhage | 13.28 | 9.42 | 6 | 142759 | 88 | 53206213 |
Aborted pregnancy | 13.24 | 9.42 | 5 | 142760 | 45 | 53206256 |
Dry eye | 13.15 | 9.42 | 46 | 142719 | 33598 | 53172703 |
Breast cancer metastatic | 13.08 | 9.42 | 13 | 142752 | 15315 | 53190986 |
Aspergillus infection | 13.08 | 9.42 | 47 | 142718 | 7449 | 53198852 |
X-ray abnormal | 13.00 | 9.42 | 23 | 142742 | 2343 | 53203958 |
Therapeutic reaction time decreased | 12.97 | 9.42 | 17 | 142748 | 1330 | 53204971 |
Shared psychotic disorder | 12.93 | 9.42 | 4 | 142761 | 18 | 53206283 |
Hypercapnia | 12.89 | 9.42 | 36 | 142729 | 4991 | 53201310 |
Erythema | 12.85 | 9.42 | 528 | 142237 | 156441 | 53049860 |
Agitation | 12.78 | 9.42 | 98 | 142667 | 58528 | 53147773 |
Hypertensive crisis | 12.73 | 9.42 | 12 | 142753 | 14494 | 53191807 |
Palmar-plantar erythrodysaesthesia syndrome | 12.72 | 9.42 | 24 | 142741 | 21582 | 53184719 |
Ear canal erythema | 12.71 | 9.42 | 3 | 142762 | 3 | 53206298 |
Astrocytoma | 12.70 | 9.42 | 6 | 142759 | 98 | 53206203 |
Secondary hypogonadism | 12.65 | 9.42 | 6 | 142759 | 99 | 53206202 |
Skin atrophy | 12.64 | 9.42 | 34 | 142731 | 4612 | 53201689 |
Blood growth hormone increased | 12.61 | 9.42 | 10 | 142755 | 428 | 53205873 |
Embolism venous | 12.59 | 9.42 | 26 | 142739 | 2973 | 53203328 |
Suffocation feeling | 12.58 | 9.42 | 17 | 142748 | 1370 | 53204931 |
Transient ischaemic attack | 12.56 | 9.42 | 51 | 142714 | 35674 | 53170627 |
Device difficult to use | 12.54 | 9.42 | 6 | 142759 | 10353 | 53195948 |
PCO2 increased | 12.46 | 9.42 | 16 | 142749 | 1227 | 53205074 |
Herpes simplex hepatitis | 12.44 | 9.42 | 9 | 142756 | 335 | 53205966 |
Coronary artery dissection | 12.40 | 9.42 | 13 | 142752 | 801 | 53205500 |
Pneumatosis | 12.37 | 9.42 | 10 | 142755 | 440 | 53205861 |
Autoimmune nephritis | 12.37 | 9.42 | 9 | 142756 | 338 | 53205963 |
Glucocorticoid deficiency | 12.35 | 9.42 | 8 | 142757 | 248 | 53206053 |
Pseudomonas infection | 12.34 | 9.42 | 58 | 142707 | 10370 | 53195931 |
Renal failure | 12.29 | 9.42 | 233 | 142532 | 118219 | 53088082 |
Status asthmaticus | 12.28 | 9.42 | 14 | 142751 | 948 | 53205353 |
Lung hyperinflation | 12.25 | 9.42 | 16 | 142749 | 1248 | 53205053 |
Coronary artery disease | 12.22 | 9.42 | 47 | 142718 | 33390 | 53172911 |
Blood corticotrophin decreased | 11.96 | 9.42 | 8 | 142757 | 262 | 53206039 |
Geotrichum infection | 11.95 | 9.42 | 10 | 142755 | 462 | 53205839 |
Prescription drug used without a prescription | 11.94 | 9.42 | 19 | 142746 | 1775 | 53204526 |
Nasopharyngitis | 11.91 | 9.42 | 629 | 142136 | 191666 | 53014635 |
Skin injury | 11.89 | 9.42 | 18 | 142747 | 1610 | 53204691 |
Dizziness | 11.85 | 9.42 | 847 | 141918 | 371412 | 52834889 |
International normalised ratio increased | 11.80 | 9.42 | 77 | 142688 | 47684 | 53158617 |
Cerebrospinal fluid leakage | 11.78 | 9.42 | 14 | 142751 | 992 | 53205309 |
Eosinophilic oesophagitis | 11.57 | 9.42 | 8 | 142757 | 277 | 53206024 |
Vulvovaginal pain | 11.52 | 9.42 | 22 | 142743 | 2377 | 53203924 |
Crohn's disease | 11.50 | 9.42 | 42 | 142723 | 6708 | 53199593 |
No adverse event | 11.46 | 9.42 | 60 | 142705 | 39205 | 53167096 |
Anorectal ulcer | 11.41 | 9.42 | 5 | 142760 | 68 | 53206233 |
Heart rate decreased | 11.40 | 9.42 | 150 | 142615 | 36797 | 53169504 |
Toxic skin eruption | 11.38 | 9.42 | 11 | 142754 | 13128 | 53193173 |
Fluid retention | 11.37 | 9.42 | 92 | 142673 | 54309 | 53151992 |
Product storage error | 11.36 | 9.42 | 11 | 142754 | 13119 | 53193182 |
Foetal exposure during pregnancy | 11.32 | 9.42 | 51 | 142714 | 34664 | 53171637 |
Therapeutic product effect decreased | 11.30 | 9.42 | 427 | 142338 | 125228 | 53081073 |
Pneumatosis intestinalis | 11.28 | 9.42 | 21 | 142744 | 2225 | 53204076 |
Staphylococcal infection | 11.28 | 9.42 | 155 | 142610 | 38393 | 53167908 |
Parkinsonism | 11.25 | 9.42 | 5 | 142760 | 9008 | 53197293 |
Non-consummation | 11.21 | 9.42 | 5 | 142760 | 71 | 53206230 |
Sensitivity to weather change | 11.21 | 9.42 | 39 | 142726 | 6083 | 53200218 |
Extrapyramidal disorder | 11.19 | 9.42 | 10 | 142755 | 12392 | 53193909 |
Abnormal faeces | 11.17 | 9.42 | 32 | 142733 | 4502 | 53201799 |
Dystonia | 11.16 | 9.42 | 11 | 142754 | 13010 | 53193291 |
Thyrotoxic crisis | 11 | 9.42 | 12 | 142753 | 774 | 53205527 |
Blood triglycerides decreased | 10.97 | 9.42 | 5 | 142760 | 75 | 53206226 |
Ankle fracture | 10.96 | 9.42 | 17 | 142748 | 16498 | 53189803 |
Lower respiratory tract infection | 10.96 | 9.42 | 320 | 142445 | 90661 | 53115640 |
Intestinal stenosis | 10.85 | 9.42 | 23 | 142742 | 2678 | 53203623 |
Bronchopulmonary aspergillosis | 10.85 | 9.42 | 49 | 142716 | 8616 | 53197685 |
Myelosuppression | 10.81 | 9.42 | 11 | 142754 | 12817 | 53193484 |
Pituitary infarction | 10.79 | 9.42 | 4 | 142761 | 34 | 53206267 |
Enteritis | 10.78 | 9.42 | 44 | 142721 | 7402 | 53198899 |
Feeding intolerance | 10.77 | 9.42 | 10 | 142755 | 531 | 53205770 |
Aspartate aminotransferase increased | 10.77 | 9.42 | 159 | 142606 | 83870 | 53122431 |
Respiratory depression | 10.77 | 9.42 | 11 | 142754 | 12795 | 53193506 |
Seizure | 10.75 | 9.42 | 264 | 142501 | 129245 | 53077056 |
Decreased appetite | 10.73 | 9.42 | 468 | 142297 | 214506 | 52991795 |
Drug eruption | 10.71 | 9.42 | 33 | 142732 | 25061 | 53181240 |
Muscle rigidity | 10.71 | 9.42 | 8 | 142757 | 10833 | 53195468 |
Brachycephaly | 10.69 | 9.42 | 4 | 142761 | 35 | 53206266 |
Myoclonus | 10.68 | 9.42 | 16 | 142749 | 15748 | 53190553 |
Bacterial infection | 10.68 | 9.42 | 82 | 142683 | 17465 | 53188836 |
Oesophageal adenocarcinoma recurrent | 10.59 | 9.42 | 4 | 142761 | 36 | 53206265 |
Gastrointestinal scarring | 10.58 | 9.42 | 7 | 142758 | 225 | 53206076 |
Pain | 10.52 | 9.42 | 1759 | 141006 | 586639 | 52619662 |
Wound secretion | 10.50 | 9.42 | 30 | 142735 | 4213 | 53202088 |
Ileectomy | 10.48 | 9.42 | 6 | 142759 | 148 | 53206153 |
Kidney infection | 10.45 | 9.42 | 87 | 142678 | 18980 | 53187321 |
Reaction to preservatives | 10.44 | 9.42 | 7 | 142758 | 230 | 53206071 |
Encephalitis autoimmune | 10.44 | 9.42 | 15 | 142750 | 1281 | 53205020 |
Adjustment disorder with depressed mood | 10.40 | 9.42 | 22 | 142743 | 2558 | 53203743 |
Thrombocytopenia | 10.40 | 9.42 | 287 | 142478 | 138440 | 53067861 |
Visual pathway disorder | 10.40 | 9.42 | 4 | 142761 | 38 | 53206263 |
Tuberous sclerosis complex | 10.35 | 9.42 | 5 | 142760 | 86 | 53206215 |
Uterine cyst | 10.34 | 9.42 | 9 | 142756 | 439 | 53205862 |
Akathisia | 10.32 | 9.42 | 5 | 142760 | 8566 | 53197735 |
Depression | 10.31 | 9.42 | 393 | 142372 | 182659 | 53023642 |
Arrhythmia | 10.29 | 9.42 | 57 | 142708 | 36722 | 53169579 |
Osteopenia | 10.28 | 9.42 | 21 | 142744 | 18334 | 53187967 |
Respiratory acidosis | 10.26 | 9.42 | 39 | 142726 | 6349 | 53199952 |
Proctitis | 10.26 | 9.42 | 19 | 142746 | 2006 | 53204295 |
Faecal calprotectin abnormal | 10.22 | 9.42 | 4 | 142761 | 40 | 53206261 |
Anti-thyroid antibody positive | 10.12 | 9.42 | 9 | 142756 | 452 | 53205849 |
Thyroxine free increased | 10.07 | 9.42 | 12 | 142753 | 852 | 53205449 |
Pruritus | 10.06 | 9.42 | 915 | 141850 | 292917 | 52913384 |
Colonic abscess | 10.01 | 9.42 | 12 | 142753 | 858 | 53205443 |
Blood gonadotrophin decreased | 9.98 | 9.42 | 3 | 142762 | 12 | 53206289 |
Mobility decreased | 9.95 | 9.42 | 271 | 142494 | 76000 | 53130301 |
Blood smear test abnormal | 9.86 | 9.42 | 5 | 142760 | 96 | 53206205 |
Pulmonary hypertension | 9.77 | 9.42 | 59 | 142706 | 37211 | 53169090 |
Maternal exposure timing unspecified | 9.76 | 9.42 | 24 | 142741 | 3082 | 53203219 |
Skin wrinkling | 9.74 | 9.42 | 13 | 142752 | 1035 | 53205266 |
Dislocation of vertebra | 9.69 | 9.42 | 22 | 142743 | 2684 | 53203617 |
Pneumonia aspiration | 9.69 | 9.42 | 53 | 142712 | 34248 | 53172053 |
Vaccination site inflammation | 9.65 | 9.42 | 4 | 142761 | 47 | 53206254 |
Aplastic anaemia | 9.64 | 9.42 | 46 | 142719 | 8275 | 53198026 |
Pleural effusion | 9.57 | 9.42 | 173 | 142592 | 88406 | 53117895 |
Oropharyngeal pain | 9.56 | 9.42 | 285 | 142480 | 80983 | 53125318 |
Hallucination | 9.52 | 9.42 | 95 | 142670 | 53743 | 53152558 |
Pneumopericardium | 9.50 | 9.42 | 4 | 142761 | 49 | 53206252 |
Therapy interrupted | 9.45 | 9.42 | 24 | 142741 | 19412 | 53186889 |
Drug resistance | 9.44 | 9.42 | 25 | 142740 | 19937 | 53186364 |
Blood corticotrophin increased | 9.43 | 9.42 | 4 | 142761 | 50 | 53206251 |
Neutrophilic panniculitis | 9.43 | 9.42 | 4 | 142761 | 50 | 53206251 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Adrenal insufficiency | 236.27 | 9.74 | 208 | 76304 | 11760 | 32425254 |
Infusion related reaction | 170.30 | 9.74 | 349 | 76163 | 45250 | 32391764 |
Blood pressure fluctuation | 169.99 | 9.74 | 223 | 76289 | 19912 | 32417102 |
Craniopharyngioma | 169.19 | 9.74 | 51 | 76461 | 242 | 32436772 |
Completed suicide | 160.21 | 9.74 | 16 | 76496 | 92501 | 32344513 |
Toxicity to various agents | 155.90 | 9.74 | 115 | 76397 | 177926 | 32259088 |
Death | 153.94 | 9.74 | 430 | 76082 | 382087 | 32054927 |
Drug abuse | 149.66 | 9.74 | 10 | 76502 | 80233 | 32356781 |
Adrenocortical insufficiency acute | 147.07 | 9.74 | 70 | 76442 | 1334 | 32435680 |
Graft loss | 138.94 | 9.74 | 59 | 76453 | 849 | 32436165 |
Colitis ulcerative | 121.51 | 9.74 | 174 | 76338 | 16877 | 32420137 |
Serum sickness | 118.77 | 9.74 | 67 | 76445 | 1836 | 32435178 |
Febrile bone marrow aplasia | 114.27 | 9.74 | 119 | 76393 | 8296 | 32428718 |
Off label use | 111.12 | 9.74 | 1154 | 75358 | 305166 | 32131848 |
Hypofibrinogenaemia | 95.31 | 9.74 | 56 | 76456 | 1660 | 32435354 |
Frequent bowel movements | 94.59 | 9.74 | 114 | 76398 | 9338 | 32427676 |
Intentional product use issue | 91.61 | 9.74 | 262 | 76250 | 41949 | 32395065 |
Febrile neutropenia | 84.85 | 9.74 | 526 | 75986 | 119040 | 32317974 |
Product use issue | 82.01 | 9.74 | 292 | 76220 | 52485 | 32384529 |
Hypopituitarism | 76.00 | 9.74 | 50 | 76462 | 1817 | 32435197 |
Diabetes insipidus | 75.72 | 9.74 | 57 | 76455 | 2575 | 32434439 |
Leukoencephalopathy | 74.10 | 9.74 | 68 | 76444 | 4057 | 32432957 |
Drug interaction | 69.65 | 9.74 | 271 | 76241 | 217914 | 32219100 |
Heart rate irregular | 68.92 | 9.74 | 121 | 76391 | 13957 | 32423057 |
Intentional overdose | 65.13 | 9.74 | 10 | 76502 | 41591 | 32395423 |
Inappropriate schedule of product administration | 58.36 | 9.74 | 238 | 76274 | 45587 | 32391427 |
Drug specific antibody present | 54.93 | 9.74 | 46 | 76466 | 2427 | 32434587 |
Adrenal suppression | 54.17 | 9.74 | 29 | 76483 | 715 | 32436299 |
Condition aggravated | 54.08 | 9.74 | 582 | 75930 | 155079 | 32281935 |
Pituitary tumour benign | 53.64 | 9.74 | 30 | 76482 | 808 | 32436206 |
Interstitial lung disease | 51.77 | 9.74 | 46 | 76466 | 64955 | 32372059 |
Insulin-like growth factor decreased | 50.36 | 9.74 | 20 | 76492 | 240 | 32436774 |
Steroid withdrawal syndrome | 49.31 | 9.74 | 19 | 76493 | 209 | 32436805 |
Impaired quality of life | 48.54 | 9.74 | 42 | 76470 | 2318 | 32434696 |
Tendon pain | 48.22 | 9.74 | 45 | 76467 | 2743 | 32434271 |
Septic shock | 47.30 | 9.74 | 301 | 76211 | 68688 | 32368326 |
Mucosal inflammation | 46.89 | 9.74 | 179 | 76333 | 33255 | 32403759 |
Arthralgia | 46.09 | 9.74 | 543 | 75969 | 147905 | 32289109 |
Pseudostroke | 44.10 | 9.74 | 12 | 76500 | 36 | 32436978 |
Tendon disorder | 42.61 | 9.74 | 41 | 76471 | 2597 | 32434417 |
Body temperature fluctuation | 42.19 | 9.74 | 32 | 76480 | 1462 | 32435552 |
Overdose | 41.78 | 9.74 | 89 | 76423 | 86988 | 32350026 |
Hypertriglyceridaemia | 40.19 | 9.74 | 73 | 76439 | 8646 | 32428368 |
Tendon rupture | 40.01 | 9.74 | 66 | 76446 | 7237 | 32429777 |
Suicide attempt | 39.95 | 9.74 | 20 | 76492 | 38224 | 32398790 |
Heart rate decreased | 39.61 | 9.74 | 140 | 76372 | 25060 | 32411954 |
Myocardial infarction | 38.82 | 9.74 | 158 | 76354 | 125518 | 32311496 |
Renal impairment | 37.78 | 9.74 | 102 | 76410 | 91870 | 32345144 |
Fistula | 37.69 | 9.74 | 55 | 76457 | 5424 | 32431590 |
Neoplasm recurrence | 37.27 | 9.74 | 34 | 76478 | 2013 | 32435001 |
Faecal calprotectin increased | 37.16 | 9.74 | 29 | 76483 | 1383 | 32435631 |
Aplastic anaemia | 36.90 | 9.74 | 64 | 76448 | 7309 | 32429705 |
Colitis | 36.07 | 9.74 | 167 | 76345 | 33784 | 32403230 |
Acute kidney injury | 35.55 | 9.74 | 482 | 76030 | 292986 | 32144028 |
Cortisol decreased | 35.20 | 9.74 | 24 | 76488 | 926 | 32436088 |
Hypophysitis | 35.16 | 9.74 | 33 | 76479 | 2026 | 32434988 |
Insulin-like growth factor increased | 34.78 | 9.74 | 25 | 76487 | 1051 | 32435963 |
Fall | 33.85 | 9.74 | 297 | 76215 | 195904 | 32241110 |
Crohn's disease | 33.41 | 9.74 | 46 | 76466 | 4299 | 32432715 |
Chorioretinopathy | 33.08 | 9.74 | 28 | 76484 | 1499 | 32435515 |
Glioma | 31.91 | 9.74 | 16 | 76496 | 343 | 32436671 |
Hypertrophic cardiomyopathy | 31.83 | 9.74 | 23 | 76489 | 975 | 32436039 |
Pneumoretroperitoneum | 31.81 | 9.74 | 10 | 76502 | 56 | 32436958 |
Pelvic abscess | 31.75 | 9.74 | 23 | 76489 | 979 | 32436035 |
Bronchiectasis | 31.54 | 9.74 | 58 | 76454 | 6934 | 32430080 |
Lichen planus | 31.33 | 9.74 | 22 | 76490 | 891 | 32436123 |
Epiphysiolysis | 30.90 | 9.74 | 11 | 76501 | 95 | 32436919 |
Drug hypersensitivity | 30.53 | 9.74 | 285 | 76227 | 73115 | 32363899 |
Cardiac failure | 30.38 | 9.74 | 112 | 76400 | 91561 | 32345453 |
Meningitis candida | 29.79 | 9.74 | 10 | 76502 | 71 | 32436943 |
Drug level below therapeutic | 28.69 | 9.74 | 42 | 76470 | 4153 | 32432861 |
Anaemia | 28.61 | 9.74 | 363 | 76149 | 223261 | 32213753 |
Flushing | 27.99 | 9.74 | 146 | 76366 | 30981 | 32406033 |
Myelopathy | 27.69 | 9.74 | 29 | 76483 | 2034 | 32434980 |
Therapeutic response shortened | 27.68 | 9.74 | 44 | 76468 | 4676 | 32432338 |
Pituitary haemorrhage | 27.51 | 9.74 | 12 | 76500 | 185 | 32436829 |
Perioral dermatitis | 26.28 | 9.74 | 10 | 76502 | 106 | 32436908 |
Growth retardation | 26.17 | 9.74 | 26 | 76486 | 1713 | 32435301 |
Sedation | 25.71 | 9.74 | 6 | 76506 | 18520 | 32418494 |
Stevens-Johnson syndrome | 25.27 | 9.74 | 99 | 76413 | 18610 | 32418404 |
Candida infection | 24.41 | 9.74 | 91 | 76421 | 16712 | 32420302 |
Adrenocorticotropic hormone deficiency | 24.33 | 9.74 | 16 | 76496 | 581 | 32436433 |
Thermophobia | 24.30 | 9.74 | 9 | 76503 | 88 | 32436926 |
Idiopathic intracranial hypertension | 23.57 | 9.74 | 16 | 76496 | 613 | 32436401 |
Shared psychotic disorder | 23.44 | 9.74 | 6 | 76506 | 13 | 32437001 |
Atrial fibrillation | 23.17 | 9.74 | 170 | 76342 | 116534 | 32320480 |
Cardio-respiratory arrest | 23.05 | 9.74 | 62 | 76450 | 55927 | 32381087 |
Blood pressure increased | 22.72 | 9.74 | 286 | 76226 | 79068 | 32357946 |
Symptom masked | 22.34 | 9.74 | 15 | 76497 | 564 | 32436450 |
Blood creatine phosphokinase increased | 22.20 | 9.74 | 46 | 76466 | 45430 | 32391584 |
Hallucination | 21.87 | 9.74 | 58 | 76454 | 52561 | 32384453 |
Klebsiella infection | 21.68 | 9.74 | 54 | 76458 | 7958 | 32429056 |
Gastrointestinal haemorrhage | 21.64 | 9.74 | 118 | 76394 | 86764 | 32350250 |
Thyroxine free decreased | 21.56 | 9.74 | 11 | 76501 | 245 | 32436769 |
Periorbital infection | 21.54 | 9.74 | 9 | 76503 | 124 | 32436890 |
Posterior reversible encephalopathy syndrome | 21.30 | 9.74 | 60 | 76452 | 9516 | 32427498 |
Cardiac failure congestive | 21.27 | 9.74 | 115 | 76397 | 84737 | 32352277 |
Glioblastoma multiforme | 21.07 | 9.74 | 17 | 76495 | 851 | 32436163 |
Musculoskeletal injury | 20.98 | 9.74 | 9 | 76503 | 133 | 32436881 |
Optic nerve disorder | 20.71 | 9.74 | 15 | 76497 | 638 | 32436376 |
Neurotoxicity | 20.56 | 9.74 | 80 | 76432 | 14990 | 32422024 |
Onychoclasis | 20.49 | 9.74 | 23 | 76489 | 1745 | 32435269 |
Cholangitis infective | 20.41 | 9.74 | 11 | 76501 | 275 | 32436739 |
Erythema | 20.28 | 9.74 | 291 | 76221 | 82814 | 32354200 |
Astrocytoma | 20.17 | 9.74 | 10 | 76502 | 209 | 32436805 |
Neuroleptic malignant syndrome | 20.07 | 9.74 | 8 | 76504 | 17487 | 32419527 |
Subdural haematoma | 20.00 | 9.74 | 11 | 76501 | 19942 | 32417072 |
Blood growth hormone decreased | 19.98 | 9.74 | 6 | 76506 | 28 | 32436986 |
Rash erythematous | 19.96 | 9.74 | 110 | 76402 | 23829 | 32413185 |
Dermatitis diaper | 19.71 | 9.74 | 11 | 76501 | 295 | 32436719 |
Bronchial haemorrhage | 19.35 | 9.74 | 15 | 76497 | 708 | 32436306 |
Blood growth hormone increased | 19.23 | 9.74 | 10 | 76502 | 232 | 32436782 |
Hypogonadism | 19.22 | 9.74 | 22 | 76490 | 1705 | 32435309 |
Pituitary tumour recurrent | 19.12 | 9.74 | 7 | 76505 | 66 | 32436948 |
Drug level decreased | 19.11 | 9.74 | 45 | 76467 | 6401 | 32430613 |
Vestibular neuronitis | 18.88 | 9.74 | 9 | 76503 | 172 | 32436842 |
Renal failure | 18.81 | 9.74 | 214 | 76298 | 134264 | 32302750 |
Secondary adrenocortical insufficiency | 18.55 | 9.74 | 18 | 76494 | 1152 | 32435862 |
Anaphylactic reaction | 18.46 | 9.74 | 128 | 76384 | 30044 | 32406970 |
Extrapyramidal disorder | 18.30 | 9.74 | 3 | 76509 | 11892 | 32425122 |
Anal fistula | 17.93 | 9.74 | 35 | 76477 | 4376 | 32432638 |
Diarrhoea haemorrhagic | 17.91 | 9.74 | 43 | 76469 | 6192 | 32430822 |
Pouchitis | 17.84 | 9.74 | 14 | 76498 | 673 | 32436341 |
Gastrointestinal inflammation | 17.74 | 9.74 | 29 | 76483 | 3155 | 32433859 |
Meningitis tuberculous | 17.66 | 9.74 | 14 | 76498 | 683 | 32436331 |
Gastrointestinal anastomotic leak | 17.61 | 9.74 | 11 | 76501 | 365 | 32436649 |
Cryptococcal fungaemia | 17.55 | 9.74 | 7 | 76505 | 85 | 32436929 |
Syncope | 17.53 | 9.74 | 132 | 76380 | 89992 | 32347022 |
Splenic peliosis | 17.47 | 9.74 | 5 | 76507 | 19 | 32436995 |
Hyperbilirubinaemia | 17.22 | 9.74 | 85 | 76427 | 17645 | 32419369 |
Otitis media acute | 17.18 | 9.74 | 12 | 76500 | 482 | 32436532 |
Blood thyroid stimulating hormone decreased | 17.16 | 9.74 | 22 | 76490 | 1918 | 32435096 |
Intentional product misuse | 17.15 | 9.74 | 37 | 76475 | 36014 | 32401000 |
Nervous system disorder | 17.11 | 9.74 | 72 | 76440 | 13977 | 32423037 |
Clostridium difficile infection | 17.06 | 9.74 | 85 | 76427 | 17711 | 32419303 |
Bone cyst | 17.01 | 9.74 | 13 | 76499 | 601 | 32436413 |
Angina pectoris | 16.90 | 9.74 | 30 | 76482 | 31396 | 32405618 |
Hospitalisation | 16.76 | 9.74 | 59 | 76453 | 48912 | 32388102 |
Aggression | 16.68 | 9.74 | 43 | 76469 | 39346 | 32397668 |
Joint ankylosis | 16.64 | 9.74 | 11 | 76501 | 403 | 32436611 |
Chills | 16.57 | 9.74 | 267 | 76245 | 77817 | 32359197 |
Lacrimal duct neoplasm | 16.37 | 9.74 | 5 | 76507 | 25 | 32436989 |
Mantle cell lymphoma stage III | 16.37 | 9.74 | 5 | 76507 | 25 | 32436989 |
Posturing | 16.34 | 9.74 | 12 | 76500 | 522 | 32436492 |
Lactic acidosis | 16.30 | 9.74 | 34 | 76478 | 33502 | 32403512 |
Hyperkalaemia | 16.15 | 9.74 | 97 | 76415 | 69653 | 32367361 |
Eczema | 16.14 | 9.74 | 74 | 76438 | 14906 | 32422108 |
Product quality issue | 16.05 | 9.74 | 13 | 76499 | 19220 | 32417794 |
Pituitary tumour | 16.02 | 9.74 | 12 | 76500 | 538 | 32436476 |
Poor venous access | 15.85 | 9.74 | 27 | 76485 | 3039 | 32433975 |
Body height below normal | 15.81 | 9.74 | 9 | 76503 | 251 | 32436763 |
Cerebrospinal fluid leakage | 15.50 | 9.74 | 11 | 76501 | 453 | 32436561 |
Electrocardiogram QT prolonged | 15.50 | 9.74 | 45 | 76467 | 39596 | 32397418 |
Body temperature decreased | 15.46 | 9.74 | 59 | 76453 | 10955 | 32426059 |
Thyroxine decreased | 15.43 | 9.74 | 7 | 76505 | 119 | 32436895 |
Anal inflammation | 15.26 | 9.74 | 10 | 76502 | 361 | 32436653 |
Abdominal pain | 15.21 | 9.74 | 460 | 76052 | 149069 | 32287945 |
Congenital cardiovascular anomaly | 15.17 | 9.74 | 8 | 76504 | 191 | 32436823 |
Intentional self-injury | 14.92 | 9.74 | 7 | 76505 | 13893 | 32423121 |
Coma | 14.81 | 9.74 | 51 | 76461 | 42561 | 32394453 |
Addison's disease | 14.70 | 9.74 | 4 | 76508 | 12 | 32437002 |
Renal disorder | 14.50 | 9.74 | 23 | 76489 | 25160 | 32411854 |
Cushingoid | 14.42 | 9.74 | 24 | 76488 | 2650 | 32434364 |
Anal abscess | 14.42 | 9.74 | 37 | 76475 | 5553 | 32431461 |
Groin infection | 14.22 | 9.74 | 7 | 76505 | 144 | 32436870 |
Pulmonary arterial hypertension | 13.99 | 9.74 | 3 | 76509 | 9818 | 32427196 |
Perirectal abscess | 13.85 | 9.74 | 18 | 76494 | 1591 | 32435423 |
Gingival disorder | 13.84 | 9.74 | 17 | 76495 | 1420 | 32435594 |
Lichenification | 13.70 | 9.74 | 9 | 76503 | 326 | 32436688 |
Feeling hot | 13.68 | 9.74 | 77 | 76435 | 16809 | 32420205 |
Anaplastic astrocytoma | 13.55 | 9.74 | 7 | 76505 | 160 | 32436854 |
Perineal pain | 13.42 | 9.74 | 13 | 76499 | 830 | 32436184 |
Feeling cold | 13.38 | 9.74 | 53 | 76459 | 10011 | 32427003 |
Mean cell volume decreased | 13.33 | 9.74 | 16 | 76496 | 1304 | 32435710 |
Gastroenteritis | 13.32 | 9.74 | 67 | 76445 | 14014 | 32423000 |
Coronary artery disease | 13.22 | 9.74 | 66 | 76446 | 49640 | 32387374 |
Hydrocephalus | 13.22 | 9.74 | 32 | 76480 | 4633 | 32432381 |
Prothrombin level abnormal | 13.07 | 9.74 | 6 | 76506 | 105 | 32436909 |
Short-bowel syndrome | 12.98 | 9.74 | 8 | 76504 | 259 | 32436755 |
Contraindicated product prescribed | 12.94 | 9.74 | 9 | 76503 | 359 | 32436655 |
Respiratory disorder | 12.85 | 9.74 | 84 | 76428 | 19333 | 32417681 |
Morganella infection | 12.85 | 9.74 | 10 | 76502 | 475 | 32436539 |
Clostridium test positive | 12.77 | 9.74 | 21 | 76491 | 2296 | 32434718 |
Somnolence | 12.68 | 9.74 | 170 | 76342 | 103627 | 32333387 |
Sitting disability | 12.67 | 9.74 | 6 | 76506 | 113 | 32436901 |
Blood luteinising hormone decreased | 12.67 | 9.74 | 6 | 76506 | 113 | 32436901 |
Pharyngitis bacterial | 12.66 | 9.74 | 5 | 76507 | 59 | 32436955 |
Hypothalamo-pituitary disorder | 12.65 | 9.74 | 12 | 76500 | 747 | 32436267 |
Adenoidal hypertrophy | 12.62 | 9.74 | 6 | 76506 | 114 | 32436900 |
Oxygen saturation abnormal | 12.61 | 9.74 | 15 | 76497 | 1211 | 32435803 |
Cerebral infarction | 12.59 | 9.74 | 29 | 76483 | 27585 | 32409429 |
Shunt malfunction | 12.57 | 9.74 | 7 | 76505 | 187 | 32436827 |
Transient aphasia | 12.53 | 9.74 | 6 | 76506 | 116 | 32436898 |
Toxic epidermal necrolysis | 12.38 | 9.74 | 87 | 76425 | 20506 | 32416508 |
Phaeochromocytoma crisis | 12.37 | 9.74 | 5 | 76507 | 63 | 32436951 |
Paraesthesia | 12.29 | 9.74 | 201 | 76311 | 58743 | 32378271 |
Intestinal stenosis | 12.26 | 9.74 | 19 | 76493 | 1976 | 32435038 |
Hepatic function abnormal | 12.23 | 9.74 | 59 | 76453 | 44781 | 32392233 |
Blood corticotrophin increased | 12.23 | 9.74 | 5 | 76507 | 65 | 32436949 |
Epileptic encephalopathy | 12.21 | 9.74 | 6 | 76506 | 123 | 32436891 |
Trichosporon infection | 12.17 | 9.74 | 12 | 76500 | 783 | 32436231 |
Wrong technique in product usage process | 12.16 | 9.74 | 42 | 76470 | 35017 | 32401997 |
Foetal exposure during pregnancy | 12.07 | 9.74 | 53 | 76459 | 41248 | 32395766 |
Blood creatinine increased | 11.91 | 9.74 | 157 | 76355 | 95975 | 32341039 |
Administration site bruise | 11.88 | 9.74 | 3 | 76509 | 6 | 32437008 |
Congenital adrenal gland hypoplasia | 11.88 | 9.74 | 3 | 76509 | 6 | 32437008 |
Accidental overdose | 11.78 | 9.74 | 17 | 76495 | 19322 | 32417692 |
Malignant neoplasm progression | 11.73 | 9.74 | 123 | 76389 | 78373 | 32358641 |
Anal fissure | 11.72 | 9.74 | 23 | 76489 | 2886 | 32434128 |
Tendonitis | 11.61 | 9.74 | 46 | 76466 | 8689 | 32428325 |
Blood culture positive | 11.60 | 9.74 | 32 | 76480 | 5013 | 32432001 |
Bradycardia | 11.58 | 9.74 | 110 | 76402 | 71452 | 32365562 |
Drug ineffective | 11.45 | 9.74 | 1049 | 75463 | 382428 | 32054586 |
Hepatitis C | 11.45 | 9.74 | 9 | 76503 | 13509 | 32423505 |
Serotonin syndrome | 11.45 | 9.74 | 17 | 76495 | 19100 | 32417914 |
Rectal abscess | 11.45 | 9.74 | 13 | 76499 | 999 | 32436015 |
Unmasking of previously unidentified disease | 11.42 | 9.74 | 11 | 76501 | 698 | 32436316 |
Hyperthyroidism | 11.42 | 9.74 | 48 | 76464 | 9314 | 32427700 |
Pyrexia | 11.40 | 9.74 | 887 | 75625 | 319081 | 32117933 |
Blood pressure diastolic decreased | 11.32 | 9.74 | 40 | 76472 | 7157 | 32429857 |
Proteus infection | 11.22 | 9.74 | 12 | 76500 | 862 | 32436152 |
Tooth injury | 11.21 | 9.74 | 12 | 76500 | 863 | 32436151 |
Dactylitis | 11.21 | 9.74 | 10 | 76502 | 575 | 32436439 |
Tracheobronchitis | 11.18 | 9.74 | 13 | 76499 | 1025 | 32435989 |
Platelet count decreased | 11.16 | 9.74 | 196 | 76316 | 114395 | 32322619 |
Febrile convulsion | 11.16 | 9.74 | 10 | 76502 | 578 | 32436436 |
Pallor | 11.14 | 9.74 | 92 | 76420 | 22789 | 32414225 |
Proctitis | 11.07 | 9.74 | 20 | 76492 | 2358 | 32434656 |
Kounis syndrome | 11.07 | 9.74 | 18 | 76494 | 1950 | 32435064 |
Melaena | 11.05 | 9.74 | 43 | 76469 | 34622 | 32402392 |
Suicidal ideation | 11.05 | 9.74 | 49 | 76463 | 38034 | 32398980 |
Myelitis transverse | 11.05 | 9.74 | 13 | 76499 | 1038 | 32435976 |
Depressed level of consciousness | 11.00 | 9.74 | 54 | 76458 | 40793 | 32396221 |
Peritonitis bacterial | 11.00 | 9.74 | 8 | 76504 | 12488 | 32424526 |
Pneumonia | 10.96 | 9.74 | 705 | 75807 | 354547 | 32082467 |
Abdominal abscess | 10.95 | 9.74 | 28 | 76484 | 4193 | 32432821 |
Osteolysis | 10.94 | 9.74 | 17 | 76495 | 1772 | 32435242 |
Respiratory depression | 10.94 | 9.74 | 9 | 76503 | 13202 | 32423812 |
Antibody test abnormal | 10.92 | 9.74 | 6 | 76506 | 156 | 32436858 |
Diplegia | 10.89 | 9.74 | 13 | 76499 | 1054 | 32435960 |
Delirium | 10.86 | 9.74 | 60 | 76452 | 43986 | 32393028 |
Therapy cessation | 10.85 | 9.74 | 13 | 76499 | 16000 | 32421014 |
Hyperamylasaemia | 10.81 | 9.74 | 10 | 76502 | 603 | 32436411 |
Hypernatraemia | 10.66 | 9.74 | 43 | 76469 | 8190 | 32428824 |
Psychotic disorder | 10.64 | 9.74 | 24 | 76488 | 22996 | 32414018 |
Cortisol abnormal | 10.63 | 9.74 | 4 | 76508 | 41 | 32436973 |
Rhabdomyolysis | 10.63 | 9.74 | 104 | 76408 | 67161 | 32369853 |
Functional gastrointestinal disorder | 10.60 | 9.74 | 19 | 76493 | 2227 | 32434787 |
Peptic ulcer haemorrhage | 10.57 | 9.74 | 9 | 76503 | 486 | 32436528 |
Leptotrichia infection | 10.57 | 9.74 | 5 | 76507 | 94 | 32436920 |
Gonadotrophin deficiency | 10.55 | 9.74 | 4 | 76508 | 42 | 32436972 |
Urticaria | 10.54 | 9.74 | 198 | 76314 | 59416 | 32377598 |
Mental fatigue | 10.42 | 9.74 | 5 | 76507 | 97 | 32436917 |
Drug-induced liver injury | 10.39 | 9.74 | 26 | 76486 | 24037 | 32412977 |
Retinal scar | 10.27 | 9.74 | 7 | 76505 | 270 | 32436744 |
Hypersensitivity | 10.26 | 9.74 | 192 | 76320 | 57566 | 32379448 |
Inflammatory bowel disease | 10.26 | 9.74 | 20 | 76492 | 2498 | 32434516 |
Spondylolisthesis | 10.21 | 9.74 | 11 | 76501 | 797 | 32436217 |
Pharyngitis streptococcal | 10.15 | 9.74 | 18 | 76494 | 2092 | 32434922 |
Gastric ulcer perforation | 10.03 | 9.74 | 12 | 76500 | 975 | 32436039 |
Strongyloidiasis | 10.02 | 9.74 | 20 | 76492 | 2541 | 32434473 |
Hepatic cirrhosis | 10.02 | 9.74 | 15 | 76497 | 16794 | 32420220 |
Mucosal hyperaemia | 9.99 | 9.74 | 3 | 76509 | 14 | 32437000 |
Skin injury | 9.96 | 9.74 | 13 | 76499 | 1154 | 32435860 |
Haemorrhoidal haemorrhage | 9.96 | 9.74 | 23 | 76489 | 3231 | 32433783 |
Arm amputation | 9.94 | 9.74 | 5 | 76507 | 108 | 32436906 |
Graft versus host disease | 9.93 | 9.74 | 51 | 76461 | 10755 | 32426259 |
Gastroenterostomy | 9.92 | 9.74 | 4 | 76508 | 50 | 32436964 |
Cerebral haemorrhage | 9.90 | 9.74 | 45 | 76467 | 34702 | 32402312 |
Secondary hypothyroidism | 9.85 | 9.74 | 5 | 76507 | 110 | 32436904 |
Vitamin E deficiency | 9.82 | 9.74 | 3 | 76509 | 15 | 32436999 |
Source | Code | Description |
---|---|---|
ATC | A01AC03 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Corticosteroids for local oral treatment |
ATC | A07EA02 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally |
ATC | C05AA01 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Corticosteroids |
ATC | D07AA02 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, weak (group I) |
ATC | D07XA01 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, weak, other combinations |
ATC | H02AB09 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Glucocorticoids |
ATC | S01BA02 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain |
ATC | S01CB03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids/antiinfectives/mydriatics in combination |
ATC | S02BA01 | SENSORY ORGANS OTOLOGICALS CORTICOSTEROIDS Corticosteroids |
ATC | D07BA04 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, weak, combinations with antiseptics |
ATC | D07CA01 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, weak, combinations with antibiotics |
ATC | R01AD60 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
ATC | S01BB01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids and mydriatics in combination |
ATC | S01CA03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination |
ATC | S02CA03 | SENSORY ORGANS OTOLOGICALS CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination |
ATC | S03CA04 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination |
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
MeSH PA | D000893 | Anti-Inflammatory Agents |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:49167 | anti-asthmatic agents |
CHEBI has role | CHEBI:50857 | anti-allergic agents |
CHEBI has role | CHEBI:75771 | Mus musculus metabolite |
CHEBI has role | CHEBI:77746 | H. sapiens metabolites |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Disorder of musculoskeletal system | indication | 928000 | DOID:17 |
Cerebral edema | indication | 2032001 | |
Otitis externa | indication | 3135009 | |
Proctitis | indication | 3951002 | DOID:3127 |
Keratitis | indication | 5888003 | DOID:4677 |
Tinea pedis | indication | 6020002 | DOID:12403 |
Berylliosis | indication | 8247009 | DOID:10322 |
Psoriasis | indication | 9014002 | DOID:8893 |
Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
Cyclitis | indication | 17657000 | |
Rheumatic heart disease | indication | 23685000 | |
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Inflammatory bowel disease | indication | 24526004 | DOID:0050589 |
Multiple sclerosis | indication | 24700007 | DOID:2377 |
Severe adrenal insufficiency | indication | 24867002 | |
Sarcoidosis | indication | 31541009 | DOID:11335 |
Idiopathic thrombocytopenic purpura | indication | 32273002 | DOID:8924 |
Psoriasis with arthropathy | indication | 33339001 | |
Crohn's disease | indication | 34000006 | |
Tendinitis | indication | 34840004 | DOID:971 |
Erythema multiforme | indication | 36715001 | |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Angioedema | indication | 41291007 | DOID:1558 |
Humoral hypercalcemia of malignancy | indication | 47709007 | |
Articular gout | indication | 48440001 | DOID:13189 |
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Edema of larynx | indication | 51599000 | |
Chronic ulcerative proctitis | indication | 52231000 | |
Nephrotic syndrome | indication | 52254009 | DOID:1184 |
Lichen simplex chronicus | indication | 53891004 | |
Systemic lupus erythematosus | indication | 55464009 | DOID:9074 |
Allergic rhinitis | indication | 61582004 | |
Ulcerative colitis | indication | 64766004 | DOID:8577 |
Löffler's syndrome | indication | 64936001 | DOID:9503 |
Iritis | indication | 65074000 | DOID:1406 |
Pemphigus | indication | 65172003 | DOID:9182 |
Granuloma annulare | indication | 65508009 | DOID:3777 |
Tenosynovitis | indication | 67801009 | DOID:970 |
Blepharoconjunctivitis | indication | 68659002 | DOID:2456 |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Hemorrhoids | indication | 70153002 | DOID:9746 |
Transfusion reaction due to serum protein reaction | indication | 72284000 | |
Acquired thrombocytopenia | indication | 74576004 | DOID:11126 |
Iridocyclitis | indication | 77971008 | |
Thyroiditis | indication | 82119001 | DOID:7166 |
Bursitis | indication | 84017003 | DOID:2965 |
Tinea corporis | indication | 84849002 | |
Autoimmune disease | indication | 85828009 | |
Corneal abrasion | indication | 85848002 | |
Infective otitis externa | indication | 86981007 | DOID:9463 |
Infection by larvae of Trichinella spiralis | indication | 88264003 | |
Acne vulgaris | indication | 88616000 | |
Congenital hypoplastic anemia | indication | 88854002 | DOID:1339 |
Pruritus ani | indication | 90446007 | |
Corneal ulcer | indication | 91514001 | DOID:8463 |
Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
Dermatitis herpetiformis | indication | 111196000 | DOID:8505 |
Hodgkin's disease | indication | 118599009 | |
Non-Hodgkin's lymphoma | indication | 118601006 | |
Mycosis fungoides | indication | 118618005 | |
Uveitis | indication | 128473001 | DOID:13141 |
Aspiration pneumonitis | indication | 155597006 | |
Asthma | indication | 195967001 | DOID:2841 |
Discoid lupus erythematosus | indication | 200938002 | |
Plaque psoriasis | indication | 200965009 | |
Transplanted organ rejection | indication | 213148006 | |
Malignant otitis externa due to Pseudomonas aeruginosa | indication | 232230009 | |
Congenital adrenal hyperplasia | indication | 237751000 | |
Scalp psoriasis | indication | 238608008 | |
Punctate keratopathy | indication | 246936005 | |
Adrenogenital disorder | indication | 267395000 | DOID:0050811 |
Pruritus of genital organs | indication | 267802000 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Infective blepharitis | indication | 312219000 | |
Bacterial keratitis | indication | 314557000 | |
Disorder of eye | indication | 371405004 | DOID:5614 |
Primary adrenocortical insufficiency | indication | 373662000 | |
Adrenal cortical hypofunction | indication | 386584007 | DOID:10493 |
Herpes zoster keratitis | indication | 397573005 | |
Rosacea | indication | 398909004 | DOID:8881 |
Tinea cruris | indication | 399029005 | |
Erythroderma | indication | 399992009 | |
Primary cutaneous T-cell lymphoma | indication | 400122007 | |
Recurrent herpes simplex labialis | indication | 402892009 | |
Autoimmune hemolytic anemia | indication | 413603009 | DOID:718 |
Synovitis | indication | 416209007 | DOID:2703 |
Aphthous ulcer of mouth | indication | 426965005 | DOID:9663 |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Post traumatic osteoarthritis | indication | 699262001 | |
Itching of ear | indication | 699392007 | |
Inflammatory dermatosis | indication | 703938007 | |
Post-Op Ocular Inflammation | indication | ||
Mastoidectomy Cavity Infections | indication | ||
Superficial Ocular Infection | indication | ||
Gingival Disorders | indication | ||
Minor Bacterial Skin Infections | indication | ||
Synovitis due to Osteoarthritis | indication | ||
Diagnostic Test for Cushing's Syndrome | indication | ||
Transfusion Reaction Urticaria | indication | ||
Staphylococcus Aureus Otitis Externa | indication | ||
Systemic Dermatomyositis | indication | ||
Erythroblastic Anemia | indication | ||
Chronic purulent otitis media | off-label use | 38394007 | DOID:14247 |
Respiratory distress syndrome in the newborn | off-label use | 46775006 | |
Adrenoleukodystrophy | off-label use | 65389002 | DOID:10588 |
Pityriasis simplex | off-label use | 200767005 | |
Allergic otitis externa | off-label use | 405821001 | |
Itching of skin | off-label use | 418363000 | |
Otitis Externa Seborrhea | off-label use | ||
Neonatal Bronchopulmonary Dysplasia | off-label use | ||
Congenital Pituitary Hypoplasia | off-label use | ||
Otitis Externa Eczema | off-label use | ||
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Herpes simplex keratitis | contraindication | 9389005 | |
Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
Inactive tuberculosis | contraindication | 11999007 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Measles | contraindication | 14189004 | DOID:8622 |
Esophagitis | contraindication | 16761005 | DOID:11963 |
Mood swings | contraindication | 18963009 | |
Infection of skin AND/OR subcutaneous tissue | contraindication | 19824006 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Abscess of intestine | contraindication | 24557004 | |
Acute tuberculosis | contraindication | 25629007 | |
Shock | contraindication | 27942005 | |
Herpes simplex dendritic keratitis | contraindication | 29943008 | |
Fungal infection of eye | contraindication | 31194008 | |
Bullous myringitis | contraindication | 33528003 | DOID:13791 |
Severe myopia | contraindication | 34187009 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Gastrointestinal fistula | contraindication | 37831005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Infectious disease | contraindication | 40733004 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Hypokalemia | contraindication | 43339004 | |
Chronic heart failure | contraindication | 48447003 | |
Tuberculosis of eye | contraindication | 49107007 | |
Duodenal ulcer disease | contraindication | 51868009 | DOID:1724 |
Perforation of tympanic membrane | contraindication | 60442001 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Third degree burn injury | contraindication | 80247002 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Decreased respiratory function | contraindication | 80954004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Krukenberg spindle | contraindication | 85430004 | |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of mucous membrane | contraindication | 95351003 | |
Bilateral cataracts | contraindication | 95722004 | |
Open wound | contraindication | 125643001 | |
Eye infection | contraindication | 128351009 | |
Seizure disorder | contraindication | 128613002 | |
Bacterial infection of eye | contraindication | 128984004 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Tuberculosis of ear | contraindication | 186269001 | |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Heart block | contraindication | 233916004 | |
Anastomosis of intestine | contraindication | 235407009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Condyloma acuminatum | contraindication | 240542006 | DOID:11168 |
Telangiectasia disorder | contraindication | 247479008 | |
Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
Injury of eye region | contraindication | 282752000 | |
Varicella-zoster virus infection | contraindication | 309465005 | |
Viral eye infection | contraindication | 312132001 | |
Viral ear infection | contraindication | 312137007 | |
Fungal ear infection | contraindication | 312148000 | |
Infective otitis media | contraindication | 312218008 | |
Skin irritation | contraindication | 367466007 | |
Vaccinia keratitis | contraindication | 397552005 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 | |
Blister | contraindication | 417237009 | |
Denuded skin | contraindication | 418242004 | |
Exposure to varicella | contraindication | 444453009 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.31 | acidic |
pKa2 | 13.65 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
5%;1% | XERESE | BAUSCH | N022436 | July 31, 2009 | RX | CREAM | TOPICAL | 7223387 | Nov. 13, 2022 | COMBINATION PRODUCT FOR THE EARLY TREATMENT OF RECURRENT HERPES LABIALIS (COLD SORES) TO REDUCE THE LIKELIHOOD OF ULCERATIVE COLD SORES AND TO SHORTEN THE LESION HEALING TIME IN ADULTS AND CHILDREN (6 YEARS OF AGE AND OLDER) |
5%;1% | XERESE | BAUSCH | N022436 | July 31, 2009 | RX | CREAM | TOPICAL | 7223387 | Nov. 13, 2022 | NEW COMBINATION PRODUCT FOR THE EARLY TREATMENT OF RECURRENT HERPES LABIALIS (COLD SORES) TO REDUCE THE LIKELIHOOD OF ULCERATIVE COLD SORES AND TO SHORTEN THE LESION HEALING TIME IN ADULTS AND ADOLESCENTS (12 YEARS OF AGE AND OLDER) |
0.5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9717740 | Nov. 19, 2032 | TREATMENT OF ADRENAL INSUFFICIENCY |
1MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9717740 | Nov. 19, 2032 | TREATMENT OF ADRENAL INSUFFICIENCY |
2MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9717740 | Nov. 19, 2032 | TREATMENT OF ADRENAL INSUFFICIENCY |
5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9717740 | Nov. 19, 2032 | TREATMENT OF ADRENAL INSUFFICIENCY |
0.5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9675559 | Jan. 10, 2033 | TREATMENT OF ADRENAL INSUFFICIENCY |
1MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9675559 | Jan. 10, 2033 | TREATMENT OF ADRENAL INSUFFICIENCY |
2MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9675559 | Jan. 10, 2033 | TREATMENT OF ADRENAL INSUFFICIENCY |
5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9675559 | Jan. 10, 2033 | TREATMENT OF ADRENAL INSUFFICIENCY |
0.5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9649280 | May 12, 2034 | TREATMENT OF ADRENAL INSUFFICIENCY |
1MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9649280 | May 12, 2034 | TREATMENT OF ADRENAL INSUFFICIENCY |
2MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9649280 | May 12, 2034 | TREATMENT OF ADRENAL INSUFFICIENCY |
5MG | ALKINDI SPRINKLE | ETON | N213876 | Sept. 29, 2020 | RX | GRANULE | ORAL | 9649280 | May 12, 2034 | TREATMENT OF ADRENAL INSUFFICIENCY |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | EC50 | 8.50 | WOMBAT-PK | CHEMBL | |||
Annexin A1 | Cytosolic other | WOMBAT-PK | |||||||
Mineralocorticoid receptor | Nuclear hormone receptor | AGONIST | IC50 | 9.95 | IUPHAR | ||||
Nitric oxide synthase, inducible | Enzyme | IC50 | 8 | WOMBAT-PK | |||||
Corticosteroid-binding globulin | Secreted | Ki | 7.88 | WOMBAT-PK | |||||
Sex hormone-binding globulin | Secreted | Kd | 6.20 | CHEMBL | |||||
Glucocorticoid receptor | Transcription factor | Kd | 7.37 | CHEMBL |
ID | Source |
---|---|
4017941 | VUID |
N0000146291 | NUI |
D00088 | KEGG_DRUG |
4017941 | VANDF |
C0020268 | UMLSCUI |
CHEBI:17650 | CHEBI |
HCY | PDB_CHEM_ID |
CHEMBL389621 | ChEMBL_ID |
DB00741 | DRUGBANK_ID |
D006854 | MESH_DESCRIPTOR_UI |
5754 | PUBCHEM_CID |
2868 | IUPHAR_LIGAND_ID |
38 | INN_ID |
WI4X0X7BPJ | UNII |
202643 | RXNORM |
174 | MMSL |
2500 | MMSL |
4837 | MMSL |
d00254 | MMSL |
002147 | NDDF |
16602005 | SNOMEDCT_US |
396458002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0012 | TABLET | 5 mg | ORAL | NDA | 15 sections |
CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0031 | TABLET | 10 mg | ORAL | NDA | 15 sections |
CORTEF | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0009-0044 | TABLET | 20 mg | ORAL | NDA | 15 sections |
CIPROHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-8531 | SUSPENSION | 10 mg | AURICULAR (OTIC) | NDA | 16 sections |
Aquanil HC | HUMAN OTC DRUG LABEL | 1 | 0096-0732 | LOTION | 0.01 g | TOPICAL | OTC monograph not final | 10 sections |
Good Sense Anti Itch | HUMAN OTC DRUG LABEL | 1 | 0113-0471 | OINTMENT | 1 g | TOPICAL | OTC monograph not final | 13 sections |
good sense anti itch | HUMAN OTC DRUG LABEL | 1 | 0113-0541 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
basic care hydrocortisone | HUMAN OTC DRUG LABEL | 1 | 0113-0793 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
Good Sense Anti Itch | HUMAN OTC DRUG LABEL | 1 | 0113-0973 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
good sense anti itch | HUMAN OTC DRUG LABEL | 1 | 0113-1369 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
Basic Case Hydrocortisone Anti-Itch | HUMAN OTC DRUG LABEL | 1 | 0113-7006 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
basic care hydrocortisone | HUMAN OTC DRUG LABEL | 1 | 0113-7369 | CREAM | 1 g | TOPICAL | OTC monograph not final | 13 sections |
HYDROCORTISONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1696 | TABLET | 5 mg | ORAL | ANDA | 14 sections |
HYDROCORTISONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1697 | TABLET | 10 mg | ORAL | ANDA | 14 sections |
HYDROCORTISONE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1700 | TABLET | 20 mg | ORAL | ANDA | 14 sections |
HYDROCORTISONE | HUMAN OTC DRUG LABEL | 1 | 0168-0014 | CREAM | 5 mg | TOPICAL | OTC monograph final | 9 sections |
hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0015 | CREAM | 10 mg | TOPICAL | ANDA | 19 sections |
HYDROCORTISONE | HUMAN OTC DRUG LABEL | 1 | 0168-0016 | OINTMENT | 5 mg | TOPICAL | OTC monograph final | 9 sections |
Hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0020 | OINTMENT | 10 mg | TOPICAL | ANDA | 18 sections |
Hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0080 | CREAM | 25 mg | TOPICAL | ANDA | 17 sections |
Hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0146 | OINTMENT | 25 mg | TOPICAL | ANDA | 17 sections |
Hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0288 | LOTION | 25 mg | TOPICAL | ANDA | 18 sections |
Texacort | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0178-0455 | SOLUTION | 25 mg | TOPICAL | ANDA | 20 sections |
KAISER PERMANENTEHydrocortisone | HUMAN OTC DRUG LABEL | 1 | 0179-8711 | OINTMENT | 1 g | TOPICAL | OTC monograph not final | 15 sections |
Xerese | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0187-5104 | CREAM | 10 mg | TOPICAL | NDA | 26 sections |
Alacort | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0316-0126 | CREAM | 10 mg | TOPICAL | ANDA | 19 sections |
Alacort | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0316-0128 | CREAM | 25 mg | TOPICAL | ANDA | 19 sections |
Hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0316-0186 | CREAM | 10 mg | TOPICAL | ANDA | 19 sections |
Hydrocortisone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0316-0193 | CREAM | 25 mg | TOPICAL | ANDA | 19 sections |
Sarna Whipped Foam | HUMAN OTC DRUG LABEL | 1 | 0316-0291 | AEROSOL, FOAM | 10 mg | TOPICAL | OTC monograph not final | 11 sections |