hydrocortisone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 1388 50-23-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone
  • 17-hydroxycorticosterone
  • acticort
  • cetacort
  • hydracort
  • hydrasson
  • hydrocortisyl
  • cortisol
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
  • Molecular weight: 362.47
  • Formula: C21H30O5
  • CLOGP: 1.89
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.26
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.23 mg/mL Bocci G, Oprea TI, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose) 353.81 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.38 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.20 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.525 Moderate 0.68
caco2-efflux Caco-2 efflux ratio (BA/AB) 17.539 Moderate 0.68
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 21.330 10^-6 cm/s Moderate 0.68
dh-clint Dog hepatocyte intrinsic clearance 7.889 uL/min/10^6 cells Moderate 0.68
dppb Dog plasma protein binding (% unbound) 39.510 % Moderate 0.68
fcs-ppb Fetal calf serum protein binding (% unbound) 62.130 % Moderate 0.68
herg hERG pIC50 4.190 pIC50 Moderate 0.68
hh-clint Human hepatocyte intrinsic clearance 4.295 uL/min/10^6 cells Moderate 0.68
hlm-clint Human liver microsomal intrinsic clearance 26.303 uL/min/mg protein Moderate 0.68
hppb Human plasma protein binding (% unbound) 29.370 % Moderate 0.68
kinase-safety-class ACVR2B,CDK5,EIF2AK3,GRK2,ITK,PDK1,PDK2,PDK4,PRKDC 9
kinase-selectivity-class GRK2,MAP2K6 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 7.674 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 15.631 Moderate 0.68
mh-clint Mouse hepatocyte intrinsic clearance 41.687 Moderate 0.68
mppb Mouse plasma protein binding (% unbound) 37.010 Moderate 0.68
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 19.409 Moderate 0.68
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 Moderate 0.68
pppb Pig plasma protein binding (% unbound) 47.120 % Moderate 0.68
rat-kpuu-brain Rat brain Kpuu 0.042 % High 1
rh-clint Rat hepatocyte intrinsic clearance 58.749 uL/min/10^6 cells Moderate 0.68
rh-fuinc Rat hepatocyte fraction unbound in incubation 84.270 % Moderate 0.68
rppb Rat plasma protein binding (% unbound) 25.220 % Moderate 0.68
solubility-dd Solubility at pH 7.4 in DMSO 845.279 uM Moderate 0.68

Approvals:

DateAgencyCompanyOrphan
May 27, 2021 EMA Diurnal Europe B.V.
Aug. 5, 1952 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pericarditis 788.55 9.71 2807 398033 267344 89960263
Duodenal ulcer perforation 780.45 9.71 2451 398389 218837 90008770
Anti-cyclic citrullinated peptide antibody positive 718.60 9.71 2490 398350 233943 89993664
Helicobacter infection 715.63 9.71 2419 398421 224431 90003176
Wound 697.50 9.71 2920 397920 300060 89927547
Infusion related reaction 662.93 9.71 3609 397231 413171 89814436
Hand deformity 639.52 9.71 2801 398039 293561 89934046
Rheumatoid factor positive 623.24 9.71 1921 398919 169729 90057878
Rheumatic fever 611.12 9.71 1772 399068 151349 90076258
Glossodynia 608.89 9.71 2926 397914 318853 89908754
Toxicity to various agents 590.33 9.71 267 400573 287579 89940028
Discomfort 583.56 9.71 2582 398258 271753 89955854
Completed suicide 567.00 9.71 16 400824 145042 90082565
Pemphigus 562.91 9.71 2894 397946 323970 89903637
Type 2 diabetes mellitus 538.11 9.71 2047 398793 201197 90026410
Systemic lupus erythematosus 532.12 9.71 3069 397771 358827 89868780
Injury 514.53 9.71 1978 398862 195371 90032236
Synovitis 500.17 9.71 2820 398020 326932 89900675
Swollen joint count increased 474.84 9.71 1319 399521 109887 90117720
Hepatic enzyme increased 470.86 9.71 2966 397874 357770 89869837
Blister 469.28 9.71 2301 398539 252697 89974910
Folliculitis 467.05 9.71 1966 398874 202387 90025220
Death 466.64 9.71 815 400025 455736 89771871
Irritable bowel syndrome 425.45 9.71 1932 398908 205516 90022091
Fall 415.25 9.71 950 399890 480860 89746747
Blood cholesterol increased 414.53 9.71 1921 398919 206091 90021516
Intentional product use issue 395.97 9.71 1953 398887 214939 90012668
Drug interaction 393.70 9.71 385 400455 276068 89951539
Muscle injury 362.72 9.71 1646 399194 175008 90052599
Fibromyalgia 362.12 9.71 1837 399003 204432 90023175
Arthropathy 356.20 9.71 2804 398036 363438 89864169
Impaired healing 347.61 9.71 1992 398848 232207 89995400
Adrenocortical insufficiency acute 334.86 9.71 183 400657 2418 90225189
Ill-defined disorder 333.94 9.71 1660 399180 183231 90044376
Swelling 333.50 9.71 3068 397772 415990 89811617
Acute kidney injury 328.84 9.71 570 400270 319817 89907790
Product dose omission issue 317.90 9.71 499 400341 291188 89936419
Abdominal discomfort 315.92 9.71 3363 397477 473965 89753642
Sleep disorder due to general medical condition, insomnia type 314.23 9.71 1264 399576 127430 90100177
Psoriatic arthropathy 303.50 9.71 1887 398953 226448 90001159
Liver injury 299.96 9.71 1520 399320 169047 90058560
Deep vein thrombosis postoperative 286.64 9.71 824 400016 69985 90157622
Drug abuse 283.44 9.71 21 400819 82326 90145281
Hypersensitivity 281.70 9.71 3162 397678 451515 89776092
Joint range of motion decreased 274.71 9.71 1259 399581 134384 90093223
Facet joint syndrome 271.77 9.71 1005 399835 97384 90130223
Intentional overdose 259.37 9.71 50 400790 93784 90133823
Anaemia 251.60 9.71 764 400076 352038 89875569
Adjustment disorder with depressed mood 250.92 9.71 682 400158 56071 90171536
Lip dry 250.76 9.71 997 399843 99958 90127649
Lower respiratory tract infection 247.78 9.71 1927 398913 248732 89978875
General physical health deterioration 244.59 9.71 2523 398317 352592 89875015
Grip strength decreased 244.37 9.71 932 399908 91644 90135963
Autoimmune disorder 242.99 9.71 820 400020 75924 90151683
Alopecia 241.91 9.71 3293 397547 491778 89735829
Mobility decreased 223.11 9.71 1882 398958 248852 89978755
Neutropenia 222.66 9.71 409 400431 224495 90003112
Maternal exposure during pregnancy 220.53 9.71 2499 398341 357564 89870043
Dislocation of vertebra 219.48 9.71 644 400196 55324 90172283
Hypercholesterolaemia 217.42 9.71 954 399886 99938 90127669
Overdose 212.63 9.71 230 400610 157479 90070128
Lower limb fracture 201.89 9.71 828 400012 84185 90143422
Sleep disorder 199.29 9.71 1529 399311 196501 90031106
Gait inability 196.74 9.71 1214 399626 145242 90082365
Stomatitis 194.44 9.71 1963 398877 272735 89954872
Live birth 190.64 9.71 774 400066 78333 90149274
C-reactive protein abnormal 187.64 9.71 1082 399758 126347 90101260
Road traffic accident 187.63 9.71 957 399883 106669 90120938
Lupus vulgaris 181.99 9.71 524 400316 44535 90183072
Atrial fibrillation 181.05 9.71 194 400646 133417 90094190
Breast cancer stage III 177.77 9.71 793 400047 83654 90143953
Suicide attempt 177.66 9.71 56 400784 75343 90152264
Gastrointestinal disorder 174.82 9.71 1820 399020 254867 89972740
Musculoskeletal stiffness 174.26 9.71 2042 398798 294490 89933117
White blood cell count decreased 173.41 9.71 295 400545 166814 90060793
Wheezing 172.63 9.71 1710 399130 236370 89991237
Hip arthroplasty 172.16 9.71 731 400109 75477 90152130
Cerebrovascular accident 170.04 9.71 177 400663 123356 90104251
Steroid withdrawal syndrome 166.45 9.71 74 400766 602 90227005
Malignant neoplasm progression 166.15 9.71 137 400703 106733 90120874
Hypotension 165.25 9.71 808 400032 324589 89903018
Disease progression 163.86 9.71 275 400565 156340 90071267
Wound infection 162.25 9.71 912 399928 105490 90122117
Platelet count decreased 159.12 9.71 224 400616 136745 90090862
Somnolence 157.50 9.71 441 400399 208643 90018964
Nausea 156.15 9.71 3732 397108 1106584 89121023
Prescribed overdose 155.69 9.71 847 399993 96778 90130829
Drug intolerance 155.11 9.71 2811 398029 444780 89782827
Condition aggravated 153.67 9.71 3580 397260 591965 89635642
Peripheral venous disease 151.73 9.71 754 400086 83167 90144440
Cough 151.65 9.71 982 399858 367980 89859627
Product use issue 151.37 9.71 2171 398669 327748 89899859
Injection site pain 151.32 9.71 340 400500 173359 90054248
Contraindicated product administered 150.62 9.71 2116 398724 318023 89909584
Sciatica 149.99 9.71 862 399978 100520 90127087
Pulmonary fibrosis 147.43 9.71 896 399944 106607 90121000
Therapeutic product effect decreased 147.24 9.71 1875 398965 275696 89951911
Haemoglobin decreased 146.88 9.71 310 400530 161646 90065961
Sedation 145.79 9.71 20 400820 48151 90179456
Joint swelling 145.74 9.71 3076 397764 500224 89727383
Colitis ulcerative 145.47 9.71 590 400250 59676 90167931
Dyspepsia 145.43 9.71 1427 399413 196733 90030874
Contusion 143.16 9.71 1720 399120 249496 89978111
Balance disorder 142.97 9.71 131 400709 96949 90130658
X-ray abnormal 142.56 9.71 484 400356 44940 90182667
Syncope 142.45 9.71 229 400611 132434 90095173
Myocardial infarction 140.11 9.71 157 400683 105815 90121792
Myelosuppression 137.06 9.71 34 400806 53557 90174050
Urticaria 136.78 9.71 2041 398799 310693 89916914
Cognitive disorder 136.56 9.71 68 400772 69339 90158268
Renal impairment 136.32 9.71 159 400681 105262 90122345
Device expulsion 136.32 9.71 12 400828 40874 90186733
Adrenal insufficiency 135.69 9.71 363 400477 29558 90198049
Tremor 134.91 9.71 298 400542 152875 90074732
Hypoaesthesia 134.46 9.71 2043 398797 312167 89915440
Coma 134.33 9.71 77 400763 72555 90155052
Dehydration 131.49 9.71 431 400409 194016 90033591
Adverse event 128.50 9.71 925 399915 116493 90111114
Drug hypersensitivity 127.61 9.71 2813 398027 460796 89766811
Thrombocytopenia 126.88 9.71 484 400356 208241 90019366
Oedema 126.45 9.71 1399 399441 198896 90028711
Prescribed underdose 125.82 9.71 660 400180 74359 90153248
Cardiac failure 125.27 9.71 181 400659 109315 90118292
Interstitial lung disease 125.01 9.71 93 400747 76312 90151295
Back pain 123.87 9.71 857 399983 316318 89911289
Cardiac failure congestive 122.17 9.71 154 400686 98540 90129067
Knee arthroplasty 121.56 9.71 705 400135 82477 90145130
Wrong technique in product usage process 121.18 9.71 84 400756 71487 90156120
Treatment failure 119.73 9.71 1949 398891 301979 89925628
Bursitis 118.99 9.71 992 399848 130662 90096945
Injection site erythema 118.52 9.71 157 400683 98345 90129262
Hyperhidrosis 117.73 9.71 268 400572 136037 90091570
Constipation 116.83 9.71 743 400097 279652 89947955
Anti-cyclic citrullinated peptide antibody 116.21 9.71 323 400517 26898 90200709
Depressed level of consciousness 116.01 9.71 91 400749 72693 90154914
Dry mouth 114.08 9.71 1281 399559 182778 90044829
C-reactive protein 109.91 9.71 347 400493 31020 90196587
Blood creatinine increased 109.79 9.71 174 400666 101212 90126395
Seizure 109.74 9.71 329 400511 152300 90075307
Feeling abnormal 109.42 9.71 376 400464 166859 90060748
Electrocardiogram QT prolonged 107.61 9.71 97 400743 72359 90155248
Gastrointestinal haemorrhage 107.41 9.71 145 400695 90103 90137504
Chronic obstructive pulmonary disease 105.92 9.71 102 400738 73727 90153880
Migraine 105.56 9.71 1297 399543 189095 90038512
Weight increased 103.84 9.71 2500 398340 415427 89812180
Renal failure 103.37 9.71 270 400570 130737 90096870
Rheumatoid arthritis 103.15 9.71 1065 399775 361549 89866058
Full blood count abnormal 102.19 9.71 19 400821 36578 90191029
Night sweats 101.72 9.71 942 399898 127824 90099783
Alanine aminotransferase increased 101.13 9.71 234 400606 118104 90109503
Liver disorder 98.75 9.71 893 399947 120376 90107231
Frequent bowel movements 94.85 9.71 500 400340 56435 90171172
Therapy interrupted 94.27 9.71 52 400788 50056 90177551
Cardiac arrest 94.17 9.71 202 400638 104733 90122874
Suicidal ideation 93.76 9.71 113 400727 73742 90153865
Inflammation 92.76 9.71 1202 399638 177390 90050217
Pleural effusion 92.08 9.71 226 400614 111765 90115842
Breast cancer stage II 91.78 9.71 354 400486 34980 90192627
Intentional self-injury 91.62 9.71 11 400829 29323 90198284
Loss of consciousness 90.59 9.71 317 400523 139921 90087686
Urinary tract infection 90.07 9.71 890 399950 304742 89922865
Cardio-respiratory arrest 89.68 9.71 88 400752 63052 90164555
Onychomycosis 89.47 9.71 365 400475 37011 90190596
Breast cancer 88.51 9.71 65 400775 53696 90173911
Confusional state 87.82 9.71 2283 398557 383922 89843685
Delirium 87.80 9.71 774 400066 103585 90124022
Blepharospasm 87.66 9.71 480 400360 54965 90172642
Ulcer haemorrhage 86.62 9.71 285 400555 26036 90201571
Serotonin syndrome 85.99 9.71 30 400810 37857 90189750
Craniopharyngioma 85.95 9.71 31 400809 134 90227473
Pneumonia 85.66 9.71 2158 398682 635901 89591706
Retinitis 85.37 9.71 367 400473 38091 90189516
Bradycardia 85.13 9.71 150 400690 83697 90143910
Onychomadesis 83.64 9.71 414 400426 45584 90182023
Obesity 83.40 9.71 772 400068 104735 90122872
COVID-19 82.91 9.71 424 400416 168419 90059188
Accidental exposure to product 82.60 9.71 42 400798 42324 90185283
Intentional product misuse 82.49 9.71 170 400670 89434 90138173
Aspartate aminotransferase increased 82.08 9.71 211 400629 102726 90124881
Walking aid user 82.05 9.71 343 400497 35163 90192444
Hypertension 81.04 9.71 2621 398219 454911 89772696
Orthostatic hypotension 80.75 9.71 42 400798 41785 90185822
Multiple sclerosis relapse 80.12 9.71 68 400772 52237 90175370
Abdominal pain upper 78.37 9.71 1976 398864 330698 89896909
Myalgia 78.16 9.71 454 400386 174671 90052936
Product label confusion 77.52 9.71 250 400590 22600 90205007
Neutrophil count decreased 77.22 9.71 123 400717 71409 90156198
Maternal exposure timing unspecified 77.20 9.71 247 400593 22236 90205371
Pancytopenia 76.90 9.71 273 400567 119990 90107617
Femur fracture 76.80 9.71 55 400785 46027 90181580
Infection 76.73 9.71 2121 398719 359973 89867634
Dysphagia 76.47 9.71 248 400592 112030 90115577
Respiratory arrest 76.25 9.71 26 400814 33285 90194322
Injection site swelling 75.49 9.71 92 400748 59747 90167860
Herpes zoster 74.70 9.71 195 400645 94449 90133158
Rash 74.08 9.71 4264 396576 791836 89435771
Palpitations 73.74 9.71 332 400508 136396 90091211
Lupus-like syndrome 73.32 9.71 417 400423 48429 90179178
Hyponatraemia 72.77 9.71 323 400517 133215 90094392
Leukopenia 72.44 9.71 217 400623 100493 90127114
Vision blurred 71.44 9.71 249 400591 110044 90117563
Therapy cessation 70.96 9.71 36 400804 36325 90191282
Unevaluable event 70.60 9.71 83 400757 54765 90172842
Lung disorder 70.50 9.71 991 399849 148892 90078715
Cardiac disorder 70.10 9.71 89 400751 56783 90170824
Agitation 69.98 9.71 118 400722 66980 90160627
Secondary adrenocortical insufficiency 69.03 9.71 67 400773 2251 90225356
Epistaxis 69.02 9.71 173 400667 84952 90142655
Cataract 68.73 9.71 134 400706 71958 90155649
Blood glucose increased 68.67 9.71 205 400635 95041 90132566
Nasopharyngitis 68.18 9.71 2317 398523 404787 89822820
Osteoarthritis 67.88 9.71 1230 399610 194500 90033107
Amnesia 67.57 9.71 756 400084 107749 90119858
Dysarthria 67.43 9.71 85 400755 54397 90173210
Blood creatine phosphokinase increased 67.43 9.71 33 400807 33990 90193617
Hepatic function abnormal 66.33 9.71 64 400776 46224 90181383
Respiratory failure 65.39 9.71 285 400555 118133 90109474
Osteonecrosis of jaw 64.73 9.71 47 400793 39056 90188551
Hyperadrenocorticism 64.54 9.71 35 400805 455 90227152
Abortion spontaneous 64.16 9.71 87 400753 53969 90173638
Vertigo 63.79 9.71 133 400707 69678 90157929
Exostosis 62.45 9.71 426 400414 52708 90174899
Rhabdomyolysis 62.36 9.71 81 400759 51175 90176432
Drug eruption 62.03 9.71 40 400800 35367 90192240
Metastases to bone 61.78 9.71 18 400822 25487 90202120
Aphasia 61.58 9.71 59 400781 42753 90184854
Pulmonary embolism 61.15 9.71 334 400506 130486 90097121
Drug tolerance decreased 61.15 9.71 293 400547 31837 90195770
Neoplasm progression 60.90 9.71 64 400776 44422 90183185
Laryngitis 60.90 9.71 409 400431 50344 90177263
Sepsis 59.70 9.71 508 400332 179306 90048301
Melaena 58.69 9.71 41 400799 34756 90192851
Chronic kidney disease 58.35 9.71 82 400758 50109 90177498
Diarrhoea 58.29 9.71 3481 397359 935709 89291898
Hypofibrinogenaemia 57.40 9.71 48 400792 1322 90226285
Device dislocation 57.32 9.71 34 400806 31448 90196159
Pulmonary hypertension 57.29 9.71 62 400778 42461 90185146
Liver function test abnormal 57.21 9.71 85 400755 50760 90176847
Skin ulcer 57.04 9.71 83 400757 49992 90177615
Epilepsy 56.87 9.71 585 400255 81621 90145986
Hallucination 56.68 9.71 130 400710 65829 90161778
Hyperkalaemia 56.67 9.71 127 400713 64837 90162770
Hypoxia 56.50 9.71 150 400690 72249 90155358
International normalised ratio increased 56.32 9.71 76 400764 47240 90180367
Adverse drug reaction 56.24 9.71 775 400065 115926 90111681
Lactic acidosis 56.16 9.71 85 400755 50378 90177229
Influenza 55.93 9.71 373 400467 138891 90088716
Arrhythmia 55.63 9.71 63 400777 42269 90185338
Plasma cell myeloma 55.60 9.71 59 400781 40769 90186838
Sinusitis 55.24 9.71 1944 398896 341144 89886463
Drug withdrawal syndrome 55.21 9.71 29 400811 28694 90198913
Poisoning 54.98 9.71 3 400837 15214 90212393
Creatinine renal clearance decreased 54.54 9.71 9 400831 18890 90208717
Eye injury 54.37 9.71 138 400702 10882 90216725
Disability 54.19 9.71 337 400503 40408 90187199
Dyskinesia 54.13 9.71 49 400791 36485 90191122
Dry eye 54.09 9.71 109 400731 57822 90169785
Acute myocardial infarction 53.88 9.71 45 400795 34845 90192762
Thrombosis 53.28 9.71 157 400683 73094 90154513
Metabolic acidosis 52.63 9.71 104 400736 55572 90172035
Metastases to liver 52.61 9.71 31 400809 28776 90198831
Poisoning deliberate 51.94 9.71 6 400834 16480 90211127
Blood calcium decreased 51.65 9.71 35 400805 30147 90197460
Basal cell carcinoma 51.64 9.71 43 400797 33346 90194261
Neuroleptic malignant syndrome 51.51 9.71 4 400836 15092 90212515
Injection site bruising 50.93 9.71 96 400744 52211 90175396
Female genital tract fistula 50.55 9.71 184 400656 17684 90209923
Product prescribing error 50.21 9.71 36 400804 30109 90197498
Porphyria acute 49.92 9.71 184 400656 17791 90209816
Cellulitis 49.71 9.71 221 400619 91116 90136491
Pituitary tumour benign 49.67 9.71 54 400786 2078 90225529
Red blood cell sedimentation rate abnormal 48.69 9.71 23 400817 24181 90203426
Bone erosion 48.67 9.71 401 400439 52620 90174987
Seronegative arthritis 48.43 9.71 184 400656 18050 90209557
Blood alkaline phosphatase increased 47.91 9.71 87 400753 47992 90179615
Foetal death 47.74 9.71 16 400824 20707 90206900
Urinary retention 47.64 9.71 58 400782 37686 90189921
Lung neoplasm malignant 47.41 9.71 24 400816 24249 90203358
Transient ischaemic attack 46.83 9.71 74 400766 43102 90184505
Drug ineffective 46.76 9.71 5387 395453 1378911 88848696
Pulmonary arterial hypertension 46.67 9.71 29 400811 26158 90201449
Hypocalcaemia 46.54 9.71 72 400768 42296 90185311
Hypokalaemia 46.45 9.71 364 400476 130752 90096855
Febrile bone marrow aplasia 46.04 9.71 120 400720 9618 90217989
Drug level below therapeutic 45.98 9.71 88 400752 5726 90221881
Renal disorder 45.88 9.71 60 400780 37799 90189808
Hypomagnesaemia 45.65 9.71 54 400786 35534 90192073
Dysgeusia 45.64 9.71 103 400737 52457 90175150
Affect lability 45.15 9.71 12 400828 18051 90209556
Hepatic cirrhosis 45.13 9.71 453 400387 62800 90164807
Nail disorder 45.06 9.71 429 400411 58638 90168969
Complication associated with device 44.83 9.71 15 400825 19434 90208173
Palmar-plantar erythrodysaesthesia syndrome 44.70 9.71 35 400805 27988 90199619
Food allergy 44.33 9.71 29 400811 25449 90202158
Subcutaneous drug absorption impaired 43.97 9.71 146 400694 13399 90214208
Influenza like illness 43.90 9.71 195 400645 80416 90147191
Taste disorder 43.53 9.71 440 400400 61106 90166501
Neuropathy peripheral 43.23 9.71 392 400448 136578 90091029
Hepatotoxicity 43.01 9.71 86 400754 45756 90181851
Haematuria 42.72 9.71 55 400785 34882 90192725
Blood potassium decreased 42.70 9.71 92 400748 47635 90179972
Pregnancy 42.65 9.71 441 400399 61606 90166001
Immunodeficiency 42.40 9.71 79 400761 43155 90184452
Rheumatoid nodule 42.39 9.71 18 400822 20148 90207459
Eating disorder 42.38 9.71 37 400803 28036 90199571
Asthenia 42.36 9.71 1929 398911 531822 89695785
Blood parathyroid hormone decreased 42.36 9.71 3 400837 12213 90215394
Hypercalcaemia 41.77 9.71 54 400786 34186 90193421
Injection site pruritus 41.65 9.71 112 400728 53722 90173885
Hypophagia 41.49 9.71 59 400781 35878 90191729
Hypothalamic pituitary adrenal axis suppression 41.36 9.71 23 400817 315 90227292
Coronary artery disease 41.04 9.71 53 400787 33570 90194037
Myoclonus 40.47 9.71 17 400823 19151 90208456
Myelodysplastic syndrome 40.33 9.71 21 400819 20882 90206725
Parkinsonism 39.92 9.71 7 400833 14058 90213549
Dyspnoea exertional 39.89 9.71 174 400666 72114 90155493
Psychotic disorder 39.40 9.71 48 400792 31182 90196425
Panniculitis 39.32 9.71 8 400832 14450 90213157
Red blood cell count decreased 39.31 9.71 92 400748 46259 90181348
Drug resistance 39.27 9.71 46 400794 30403 90197204
Upper gastrointestinal haemorrhage 38.84 9.71 27 400813 22949 90204658
General symptom 38.13 9.71 147 400693 14521 90213086
Memory impairment 38.02 9.71 1142 399698 196102 90031505
Eosinophilia 38.00 9.71 42 400798 28491 90199116
Ventricular tachycardia 37.99 9.71 32 400808 24676 90202931
Ascites 37.94 9.71 98 400742 47642 90179965
Device difficult to use 37.88 9.71 15 400825 17510 90210097
Pain in jaw 37.76 9.71 99 400741 47886 90179721
Rash vesicular 37.61 9.71 170 400670 18027 90209580
Pneumonia aspiration 37.40 9.71 78 400762 40862 90186745
Bone marrow failure 37.10 9.71 53 400787 32168 90195439
Full blood count decreased 37.07 9.71 46 400794 29643 90197964
Breast cancer female 37.00 9.71 10 400830 14876 90212731
Hypervolaemia 36.62 9.71 55 400785 32702 90194905
Pulmonary oedema 36.38 9.71 146 400694 61934 90165673
Blood bilirubin increased 36.29 9.71 87 400753 43383 90184224
Altered state of consciousness 36.17 9.71 52 400788 31480 90196127
Bronchitis 36.08 9.71 468 400372 152459 90075148
Mental status changes 36.06 9.71 91 400749 44588 90183019
Haematoma 36.00 9.71 74 400766 38974 90188633
Respiratory depression 35.92 9.71 12 400828 15563 90212044
Therapy partial responder 35.83 9.71 27 400813 22016 90205591
Sedation complication 35.82 9.71 15 400825 16929 90210678
Adrenal suppression 35.50 9.71 32 400808 977 90226630
Disorientation 35.49 9.71 90 400750 44024 90183583
Restlessness 35.27 9.71 65 400775 35655 90191952
Schizophrenia 35.26 9.71 11 400829 14903 90212704
Respiratory tract infection 35.22 9.71 138 400702 58940 90168667
Hypoglycaemia 35.07 9.71 174 400666 69674 90157933
Jaundice 35.01 9.71 56 400784 32461 90195146
Vaginal flatulence 34.79 9.71 129 400711 12509 90215098
Cerebral infarction 34.49 9.71 40 400800 26556 90201051
Drug-induced liver injury 34.31 9.71 576 400264 89742 90137865
Agranulocytosis 34.29 9.71 64 400776 34938 90192669
Hypertensive crisis 34.12 9.71 18 400822 17766 90209841
Joint dislocation 34.11 9.71 324 400516 44258 90183349
Gamma-glutamyltransferase increased 34.09 9.71 73 400767 37879 90189728
Back injury 33.79 9.71 335 400505 46287 90181320
Sinus congestion 33.71 9.71 43 400797 27381 90200226
Coordination abnormal 33.65 9.71 27 400813 21329 90206278
Diabetic ketoacidosis 33.54 9.71 35 400805 24372 90203235
Surgery 33.52 9.71 95 400745 44792 90182815
Incorrect route of product administration 33.47 9.71 357 400483 50269 90177338
Normal newborn 33.46 9.71 197 400643 23165 90204442
Hypopituitarism 33.39 9.71 40 400800 1713 90225894
Therapy non-responder 33.32 9.71 816 400024 135888 90091719
Motor dysfunction 33.31 9.71 22 400818 19208 90208399
Hemiparesis 33.14 9.71 56 400784 31763 90195844
Blood urea increased 33.10 9.71 52 400788 30361 90197246
Dementia 33.03 9.71 34 400806 23827 90203780
No adverse event 32.63 9.71 172 400668 67810 90159797
Proctitis 32.63 9.71 144 400696 15115 90212492
Vaginal haemorrhage 32.60 9.71 55 400785 31216 90196391
Blood pressure fluctuation 32.53 9.71 365 400475 52048 90175559
Finger deformity 32.48 9.71 253 400587 32644 90194963
Vaginal discharge 32.45 9.71 171 400669 19293 90208314
Mitral valve incompetence 32.44 9.71 31 400809 22493 90205114
Dystonia 32.30 9.71 17 400823 16802 90210805
Deep vein thrombosis 32.14 9.71 255 400585 91365 90136242
Unresponsive to stimuli 32.06 9.71 76 400764 38045 90189562
Oxygen saturation decreased 32.03 9.71 312 400528 107171 90120436
Tardive dyskinesia 32 9.71 5 400835 10925 90216682
Hip fracture 31.95 9.71 61 400779 33016 90194591
Lymphocyte count decreased 31.83 9.71 67 400773 34983 90192624
Cholestasis 31.63 9.71 71 400769 36228 90191379
Product use in unapproved indication 31.52 9.71 1803 399037 334433 89893174
Blood pressure diastolic abnormal 31.49 9.71 25 400815 19856 90207751
Head injury 31.47 9.71 56 400784 31132 90196475
Product storage error 31.38 9.71 26 400814 20215 90207392
Cerebral haemorrhage 31.34 9.71 66 400774 34456 90193151
Muscle rigidity 31.34 9.71 12 400828 14297 90213310
Musculoskeletal disorder 31.31 9.71 30 400810 21739 90205868
Pneumonitis 31.16 9.71 96 400744 44074 90183533
Pustular psoriasis 30.92 9.71 163 400677 18393 90209214
Drug reaction with eosinophilia and systemic symptoms 30.83 9.71 92 400748 42666 90184941
Blood potassium increased 30.54 9.71 28 400812 20721 90206886
Pruritus 30.48 9.71 2786 398054 538739 89688868
Sinus disorder 30.32 9.71 67 400773 34380 90193227
Bone pain 30.21 9.71 156 400684 61827 90165780
Haematotoxicity 30.08 9.71 9 400831 12526 90215081
Ear infection 29.89 9.71 454 400386 69321 90158286
Bone disorder 29.74 9.71 35 400805 23085 90204522
Spondylitis 29.71 9.71 133 400707 14045 90213562
Breast cancer metastatic 29.50 9.71 15 400825 15117 90212490
Metastases to lung 29.50 9.71 17 400823 15974 90211633
Exposure during pregnancy 29.47 9.71 1313 399527 237097 89990510
Blood pressure increased 29.12 9.71 657 400183 196560 90031047
Ischaemic stroke 29.11 9.71 33 400807 22133 90205474
Adverse reaction 29.05 9.71 228 400612 29484 90198123
Neoplasm malignant 28.93 9.71 67 400773 33813 90193794
Akathisia 28.69 9.71 7 400833 11152 90216455
Musculoskeletal pain 28.68 9.71 975 399865 170276 90057331
Hemiplegia 28.66 9.71 18 400822 16142 90211465
Cholelithiasis 28.59 9.71 127 400713 52379 90175228
Skin necrosis 28.52 9.71 20 400820 16921 90210686
Nasal congestion 28.42 9.71 234 400606 83180 90144427
Perfume sensitivity 28.21 9.71 28 400812 967 90226640
Musculoskeletal injury 28.09 9.71 14 400826 151 90227456
Hospitalisation 28.05 9.71 398 400442 127702 90099905
Personality disorder 27.99 9.71 10 400830 12434 90215173
Extrapyramidal disorder 27.77 9.71 19 400821 16284 90211323
Diabetes mellitus inadequate control 27.75 9.71 25 400815 18659 90208948
Aggression 27.71 9.71 47 400793 26621 90200986
Angina pectoris 27.71 9.71 85 400755 39075 90188532
Disturbance in attention 27.47 9.71 111 400729 46998 90180609
Transplant rejection 27.44 9.71 11 400829 12747 90214860
COVID-19 pneumonia 27.39 9.71 24 400816 18153 90209454
Human bocavirus infection 27.28 9.71 20 400820 452 90227155
Abnormal behaviour 27.28 9.71 36 400804 22592 90205015
Cystitis 27.13 9.71 178 400662 66540 90161067
Device related bacteraemia 27.08 9.71 19 400821 400 90227207
Tooth disorder 26.93 9.71 61 400779 31029 90196578
Insulin-like growth factor increased 26.86 9.71 27 400813 947 90226660
Speech disorder 26.84 9.71 107 400733 45478 90182129
Rhinitis allergic 26.72 9.71 21 400819 16764 90210843
Blood pressure systolic abnormal 26.69 9.71 28 400812 19450 90208157
Injection site rash 26.62 9.71 41 400799 24132 90203475
Myocardial ischaemia 26.47 9.71 14 400826 13800 90213807
Cytopenia 26.34 9.71 23 400817 17426 90210181
Labelled drug-drug interaction medication error 26.19 9.71 16 400824 14566 90213041
Temperature regulation disorder 26.18 9.71 16 400824 14563 90213044
Transaminases increased 26.12 9.71 81 400759 37111 90190496
Diaphragm muscle weakness 26.11 9.71 9 400831 33 90227574
Acute generalised exanthematous pustulosis 26.10 9.71 14 400826 13689 90213918
Toxic skin eruption 26.06 9.71 19 400821 15755 90211852
Coeliac disease 26.04 9.71 307 400533 44303 90183304
Right ventricular failure 25.87 9.71 28 400812 19177 90208430
Localised infection 25.83 9.71 70 400770 33492 90194115
Dysphonia 25.80 9.71 168 400672 62916 90164691
Diabetes mellitus 25.42 9.71 175 400665 64700 90162907
Hallucination, auditory 25.42 9.71 20 400820 15955 90211652
Product administration error 25.28 9.71 49 400791 26374 90201233
Subdural haematoma 25.05 9.71 22 400818 16623 90210984
Deafness 24.98 9.71 38 400802 22476 90205131
Mydriasis 24.91 9.71 18 400822 14994 90212613
Limb injury 24.79 9.71 65 400775 31443 90196164
Rash maculo-papular 24.79 9.71 95 400745 40838 90186769
Stenotrophomonas bacteraemia 24.78 9.71 12 400828 121 90227486
Arterial occlusive disease 24.77 9.71 12 400828 12434 90215173
Gangrene 24.75 9.71 13 400827 12863 90214744
Diabetes insipidus 24.65 9.71 48 400792 3164 90224443
Haemorrhage 24.36 9.71 193 400647 69176 90158431
Metastases to central nervous system 24.28 9.71 25 400815 17517 90210090
Ulcer 24.26 9.71 70 400770 32812 90194795
Proteinuria 24.25 9.71 41 400799 23250 90204357
Chills 24.21 9.71 424 400416 131557 90096050
Urinary incontinence 24.19 9.71 85 400755 37481 90190126
Foot fracture 24.04 9.71 51 400789 26555 90201052
Nervousness 24.04 9.71 74 400766 33982 90193625
Illness 23.98 9.71 239 400601 81730 90145877
Cortisol decreased 23.93 9.71 34 400806 1725 90225882
Eye irritation 23.86 9.71 74 400766 33904 90193703
Osteomyelitis 23.83 9.71 55 400785 27791 90199816
Visual acuity reduced 23.65 9.71 42 400798 23368 90204239
Breath sounds abnormal 23.56 9.71 20 400820 15366 90212241
Radiculopathy 23.33 9.71 151 400689 18354 90209253
Acute hepatic failure 23.22 9.71 40 400800 22521 90205086
Diffuse large B-cell lymphoma 23.07 9.71 5 400835 8640 90218967
Angioedema 23.02 9.71 180 400660 64696 90162911
Torsade de pointes 22.93 9.71 20 400820 15162 90212445
Pulmonary mass 22.91 9.71 59 400781 28713 90198894
Injection site mass 22.89 9.71 39 400801 22051 90205556
Foot deformity 22.86 9.71 381 400459 59270 90168337
C-reactive protein increased 22.85 9.71 1001 399839 180388 90047219
Abortion induced 22.85 9.71 12 400828 11876 90215731
Insulin-like growth factor decreased 22.79 9.71 17 400823 395 90227212
Jaundice cholestatic 22.71 9.71 8 400832 10035 90217572
Device malfunction 22.70 9.71 36 400804 20941 90206666
Hepatic cytolysis 22.67 9.71 66 400774 30850 90196757
Rectal haemorrhage 22.65 9.71 502 400338 82242 90145365
Geotrichum infection 22.59 9.71 20 400820 596 90227011
Encephalopathy 22.57 9.71 117 400723 46327 90181280
Generalised tonic-clonic seizure 22.46 9.71 79 400761 34824 90192783
Hepatitis acute 22.44 9.71 10 400830 10877 90216730
Miosis 22.42 9.71 7 400833 9477 90218130
Electrocardiogram QRS complex prolonged 22.35 9.71 3 400837 7345 90220262
Gastrointestinal toxicity 22.35 9.71 7 400833 9460 90218147
Foetal exposure during pregnancy 22.18 9.71 106 400734 42869 90184738
Normal tension glaucoma 22.10 9.71 8 400832 35 90227572
Restless legs syndrome 22.09 9.71 41 400799 22429 90205178
Mood altered 22 9.71 26 400814 17118 90210489
Blood pressure abnormal 21.94 9.71 33 400807 19612 90207995
Tubulointerstitial nephritis 21.73 9.71 50 400790 25293 90202314
Sarcoidosis 21.69 9.71 10 400830 10663 90216944
Dyspnoea 21.63 9.71 3495 397345 877460 89350147
Atrial septal defect 21.49 9.71 5 400835 8229 90219378
Insomnia 21.45 9.71 1733 399107 331741 89895866
Peripheral swelling 21.38 9.71 2113 398727 410993 89816614
Muscle twitching 21.36 9.71 47 400793 24155 90203452
Gastric ulcer 21.31 9.71 57 400783 27391 90200216
Haematemesis 21.26 9.71 77 400763 33649 90193958
Natural killer-cell leukaemia 21.16 9.71 10 400830 95 90227512
Haemoptysis 21.05 9.71 76 400764 33244 90194363
Nodule 21.04 9.71 55 400785 26631 90200976
Grip strength 21.02 9.71 87 400753 8878 90218729
Depressed mood 20.92 9.71 133 400707 50089 90177518
Complication of device insertion 20.86 9.71 10 400830 10426 90217181
White blood cell count abnormal 20.73 9.71 4 400836 7500 90220107
Cardiomyopathy 20.64 9.71 36 400804 20170 90207437
Thirst 20.60 9.71 25 400815 16270 90211337
Heavy menstrual bleeding 20.59 9.71 37 400803 20493 90207114
Platelet count increased 20.56 9.71 38 400802 20821 90206786
Purpura 20.52 9.71 21 400819 14757 90212850
Rib fracture 20.45 9.71 55 400785 26380 90201227
Electrocardiogram abnormal 20.39 9.71 10 400830 10288 90217319
Hyperaesthesia 20.28 9.71 11 400829 10691 90216916
Atrioventricular block complete 20.24 9.71 9 400831 9802 90217805
Diverticulitis 20.22 9.71 117 400723 45070 90182537
Anal fissure 20.19 9.71 61 400779 5324 90222283
Irritability 20.19 9.71 85 400755 35577 90192030
Blood pressure systolic increased 20.18 9.71 163 400677 58182 90169425
Subarachnoid haemorrhage 20.07 9.71 30 400810 17874 90209733
Thrombotic microangiopathy 20.07 9.71 24 400816 15719 90211888
Mucous stools 20.04 9.71 60 400780 5211 90222396
Osteopenia 20.03 9.71 45 400795 22957 90204650
Apathy 19.99 9.71 12 400828 11028 90216579
Delusion 19.99 9.71 19 400821 13821 90213786
Salpingo-oophorectomy unilateral 19.95 9.71 23 400817 945 90226662
Blood test abnormal 19.92 9.71 39 400801 20913 90206694
Dizziness 19.89 9.71 2292 398548 586992 89640615
Dissociation 19.82 9.71 3 400837 6712 90220895
Nephropathy 19.80 9.71 8 400832 9227 90218380
Urosepsis 19.77 9.71 40 400800 21192 90206415
Rectal spasm 19.76 9.71 11 400829 151 90227456
Faecal calprotectin increased 19.75 9.71 50 400790 3937 90223670
Pollakiuria 19.73 9.71 77 400763 32928 90194679
Dermatitis atopic 19.68 9.71 174 400666 23298 90204309
Accidental overdose 19.56 9.71 62 400778 28211 90199396
Fusarium infection 19.49 9.71 24 400816 1058 90226549
Antithrombin III 19.45 9.71 11 400829 156 90227451
Metastases to lymph nodes 19.41 9.71 14 400826 11675 90215932
Multiple allergies 19.40 9.71 23 400817 15123 90212484
Tongue disorder 19.39 9.71 12 400828 10848 90216759
Glomerular filtration rate decreased 19.35 9.71 28 400812 16904 90210703
Joint effusion 19.34 9.71 36 400804 19674 90207933
Myositis 19.28 9.71 177 400663 23951 90203656
Blood lactate dehydrogenase increased 19.28 9.71 55 400785 25877 90201730
Arthralgia 19.24 9.71 3812 397028 774710 89452897
Unintended pregnancy 19.23 9.71 5 400835 7632 90219975
Carpal tunnel syndrome 19.10 9.71 49 400791 23879 90203728
Tinnitus 19.07 9.71 112 400728 42990 90184617
Back disorder 18.98 9.71 185 400655 25446 90202161
Rash erythematous 18.97 9.71 190 400650 64914 90162693
Urticaria thermal 18.94 9.71 17 400823 516 90227091
Lethargy 18.92 9.71 183 400657 62956 90164651
Hypersomnia 18.85 9.71 42 400798 21489 90206118
Concussion 18.79 9.71 13 400827 11078 90216529
Swollen joint count 18.76 9.71 82 400758 8571 90219036
Dysstasia 18.72 9.71 53 400787 24999 90202608
Vomiting 18.72 9.71 3133 397707 785160 89442447
Sinus tachycardia 18.71 9.71 64 400776 28449 90199158
Sensory loss 18.65 9.71 32 400808 18043 90209564
Chest discomfort 18.47 9.71 468 400372 137897 90089710
Spinal compression fracture 18.45 9.71 24 400816 15154 90212453
Bronchiectasis 18.39 9.71 45 400795 22285 90205322
Pancreatic carcinoma 18.39 9.71 7 400833 8370 90219237
Splenomegaly 18.36 9.71 18 400822 12906 90214701
Haematocrit decreased 18.35 9.71 109 400731 41723 90185884
Synovial cyst 18.34 9.71 15 400825 11737 90215870
Upper-airway cough syndrome 18.33 9.71 24 400816 15111 90212496
Chronic sinusitis 18.21 9.71 173 400667 23629 90203978
Lymphopenia 18.16 9.71 47 400793 22834 90204773
Heart rate increased 18.15 9.71 371 400469 112531 90115076
Abnormal dreams 18.03 9.71 14 400826 11243 90216364
Shock 17.94 9.71 66 400774 28712 90198895
Skin toxicity 17.93 9.71 4 400836 6775 90220832
Multiple sclerosis 17.92 9.71 63 400777 27777 90199830
Multiple fractures 17.87 9.71 10 400830 9552 90218055
Spinal stenosis 17.84 9.71 31 400809 17393 90210214
Mental impairment 17.81 9.71 29 400811 16691 90210916
Overlap syndrome 17.77 9.71 80 400760 8468 90219139
Atrial flutter 17.72 9.71 13 400827 10745 90216862
Vasculitis 17.71 9.71 47 400793 22646 90204961
Viral upper respiratory tract infection 17.68 9.71 8 400832 8626 90218981
Treatment noncompliance 17.67 9.71 145 400695 51582 90176025
Nephropathy toxic 17.65 9.71 18 400822 12670 90214937
Left ventricular failure 17.62 9.71 4 400836 6696 90220911
Device issue 17.60 9.71 69 400771 29468 90198139
Pelvic fracture 17.55 9.71 25 400815 15194 90212413
Premature labour 17.47 9.71 20 400820 13356 90214251
Body temperature fluctuation 17.46 9.71 34 400806 2241 90225366
Hyperreflexia 17.46 9.71 4 400836 6653 90220954
Gastric disorder 17.43 9.71 82 400758 33302 90194305
Coronary artery occlusion 17.41 9.71 8 400832 8546 90219061
Hypophysitis 17.36 9.71 36 400804 2484 90225123
Enthesopathy 17.34 9.71 10 400830 9394 90218213
Therapeutic response unexpected 17.32 9.71 45 400795 21835 90205772
Herpes simplex oesophagitis 17.31 9.71 11 400829 195 90227412
Spinal operation 17.21 9.71 12 400828 10184 90217423
Acute respiratory failure 17.20 9.71 115 400725 42803 90184804
Nasal oedema 17.18 9.71 4 400836 6580 90221027
Injection site warmth 17.18 9.71 32 400808 17483 90210124
Ventricular extrasystoles 17.10 9.71 20 400820 13230 90214377
Ankle fracture 16.82 9.71 41 400799 20329 90207278
Hypogonadism 16.80 9.71 9 400831 114 90227493
Intermenstrual bleeding 16.73 9.71 10 400830 9213 90218394
Major depression 16.69 9.71 12 400828 10023 90217584
Gingival bleeding 16.68 9.71 25 400815 14878 90212729
Intervertebral disc degeneration 16.56 9.71 32 400808 17242 90210365
Intervertebral disc protrusion 16.55 9.71 63 400777 27133 90200474
Movement disorder 16.53 9.71 69 400771 28950 90198657
Blindness 16.52 9.71 61 400779 26507 90201100
Colitis microscopic 16.49 9.71 15 400825 11144 90216463
Loss of employment 16.43 9.71 39 400801 2948 90224659
Invasive ductal breast carcinoma 16.40 9.71 7 400833 7811 90219796
Inappropriate antidiuretic hormone secretion 16.31 9.71 39 400801 19466 90208141
Fracture 16.28 9.71 47 400793 22029 90205578
Carotid artery occlusion 16.26 9.71 4 400836 6338 90221269
Intracranial infection 16.25 9.71 11 400829 218 90227389
Tumour marker increased 16.24 9.71 3 400837 5804 90221803
Renal injury 16.08 9.71 13 400827 10230 90217377
Femoral neck fracture 16.04 9.71 13 400827 10220 90217387
Acute myeloid leukaemia 15.92 9.71 43 400797 20597 90207010
Toothache 15.91 9.71 48 400792 22182 90205425
Drug level decreased 15.89 9.71 85 400755 9645 90217962
Bone density decreased 15.88 9.71 33 400807 17312 90210295
Pulmonary thrombosis 15.88 9.71 12 400828 9770 90217837
Atelectasis 15.87 9.71 55 400785 24354 90203253
Upper limb fracture 15.87 9.71 46 400794 21532 90206075
Withdrawal syndrome 15.86 9.71 49 400791 22475 90205132
Psychomotor hyperactivity 15.84 9.71 20 400820 12793 90214814
Drug level increased 15.82 9.71 66 400774 27696 90199911
Small intestinal obstruction 15.81 9.71 45 400795 21189 90206418
Lymphadenopathy 15.78 9.71 128 400712 45647 90181960
Tenosynovitis 15.76 9.71 25 400815 14542 90213065
Pituitary tumour recurrent 15.76 9.71 8 400832 90 90227517
Respiratory tract congestion 15.72 9.71 65 400775 27345 90200262
Lip swelling 15.70 9.71 103 400737 38507 90189100
Oesophagitis 15.64 9.71 33 400807 17216 90210391
Angina unstable 15.63 9.71 6 400834 7137 90220470
Malnutrition 15.60 9.71 37 400803 18521 90209086
Mania 15.51 9.71 24 400816 14100 90213507
Hypothyroidism 15.50 9.71 155 400685 52972 90174635
17-hydroxyprogesterone decreased 15.48 9.71 4 400836 3 90227604
Body height decreased 15.46 9.71 18 400822 11931 90215676
Fistula 15.46 9.71 99 400741 11990 90215617
Faecaloma 15.44 9.71 14 400826 10417 90217190
Atrioventricular block 15.38 9.71 10 400830 8805 90218802
Inflammatory marker increased 15.35 9.71 11 400829 9203 90218404
Sensory disturbance 15.26 9.71 28 400812 15385 90212222
Musculoskeletal discomfort 15.25 9.71 45 400795 20946 90206661
Neoplasm recurrence 15.24 9.71 40 400800 3219 90224388
Sneezing 15.23 9.71 74 400766 29795 90197812
Gastritis 15.21 9.71 115 400725 41638 90185969
Inappropriate schedule of product administration 15.21 9.71 810 400030 149123 90078484
Malignant melanoma 15.17 9.71 20 400820 12556 90215051
Steroid dependence 15.14 9.71 32 400808 2237 90225370
Therapy change 15.13 9.71 9 400831 8313 90219294
Squamous cell carcinoma of skin 15.10 9.71 7 400833 7442 90220165
Leukocytosis 15.10 9.71 78 400762 30912 90196695
Weaning failure 15.09 9.71 15 400825 519 90227088
Protein urine present 15.06 9.71 6 400834 6978 90220629
Adrenal disorder 15.00 9.71 29 400811 1901 90225706
Acute graft versus host disease 14.92 9.71 3 400837 5465 90222142
Drug level above therapeutic 14.92 9.71 58 400782 5751 90221856
Cardiotoxicity 14.91 9.71 17 400823 11372 90216235
Blood corticotrophin decreased 14.90 9.71 15 400825 527 90227080
Rhinorrhoea 14.86 9.71 288 400552 88028 90139579
Hot flush 14.79 9.71 180 400660 59308 90168299
Granulocytopenia 14.79 9.71 5 400835 6436 90221171
Chromaturia 14.78 9.71 40 400800 19147 90208460
Nightmare 14.78 9.71 48 400792 21677 90205930
Gestational diabetes 14.74 9.71 15 400825 10567 90217040
Ventricular septal defect 14.69 9.71 3 400837 5404 90222203
Substance abuse 14.68 9.71 3 400837 5403 90222204
Toxic epidermal necrolysis 14.67 9.71 84 400756 32444 90195163
Eye haemorrhage 14.67 9.71 14 400826 10166 90217441
Myocarditis 14.65 9.71 24 400816 13782 90213825
Headache 14.64 9.71 3488 397352 859258 89368349
Sickle cell anaemia with crisis 14.58 9.71 7 400833 7290 90220317
Intentional dose omission 14.52 9.71 36 400804 17747 90209860
Post-traumatic stress disorder 14.50 9.71 6 400834 6822 90220785
Meningitis candida 14.50 9.71 7 400833 70 90227537
Obstructive airways disorder 14.43 9.71 62 400778 25807 90201800
Faecal volume decreased 14.40 9.71 11 400829 265 90227342
Peritoneal tuberculosis 14.36 9.71 15 400825 551 90227056
Cardiac failure acute 14.36 9.71 19 400821 11910 90215697
Sleep apnoea syndrome 14.31 9.71 82 400758 31665 90195942
Ovarian cancer 14.29 9.71 6 400834 6761 90220846
Allergy test positive 14.24 9.71 17 400823 725 90226882
Shock haemorrhagic 14.24 9.71 20 400820 12225 90215382
Bladder cancer 14.22 9.71 4 400836 5797 90221810
Transplant dysfunction 14.21 9.71 3 400837 5279 90222328
Oral candidiasis 14.16 9.71 228 400612 35227 90192380
Progressive multifocal leukoencephalopathy 14.15 9.71 30 400810 15625 90211982
Diplopia 14.14 9.71 72 400768 28642 90198965
Organising pneumonia 14.12 9.71 8 400832 7589 90220018
Eczema herpeticum 14.07 9.71 10 400830 215 90227392
Tenderness 14.03 9.71 66 400774 26802 90200805
Skin haemorrhage 14.02 9.71 48 400792 21332 90206275
Hypothermia 13.95 9.71 30 400810 15545 90212062
Poor quality sleep 13.89 9.71 59 400781 24634 90202973
B-lymphocyte count increased 13.81 9.71 8 400832 119 90227488
Electrolyte imbalance 13.81 9.71 56 400784 23689 90203918
Blood albumin decreased 13.73 9.71 34 400806 16769 90210838
Excessive eye blinking 13.71 9.71 23 400817 1349 90226258
Haemolytic anaemia 13.70 9.71 19 400821 11678 90215929
Toxic encephalopathy 13.70 9.71 11 400829 8688 90218919
Proctalgia 13.65 9.71 72 400768 8126 90219481
Congenital anomaly 13.65 9.71 60 400780 6287 90221320
Gastric cancer 13.64 9.71 3 400837 5133 90222474
Colon cancer 13.62 9.71 17 400823 10927 90216680
Strongyloidiasis 13.61 9.71 25 400815 1577 90226030
Ataxia 13.61 9.71 38 400802 18004 90209603
Blood pressure decreased 13.60 9.71 241 400599 74654 90152953
Dizziness postural 13.58 9.71 12 400828 9041 90218566
Spinal fusion surgery 13.56 9.71 97 400743 12186 90215421
Anaphylactic shock 13.55 9.71 83 400757 31534 90196073
Large intestine polyp 13.42 9.71 13 400827 9373 90218234
Pulse absent 13.39 9.71 5 400835 6050 90221557
Productive cough 13.36 9.71 250 400590 76813 90150794
CSF lymphocyte count abnormal 13.28 9.71 3 400837 0 90227607
17-hydroxyprogesterone increased 13.28 9.71 3 400837 0 90227607
Gait disturbance 13.26 9.71 1331 399509 259165 89968442
Increased tendency to bruise 13.25 9.71 20 400820 11870 90215737
Mental disorder 13.25 9.71 86 400754 32232 90195375
Mouth ulceration 13.22 9.71 113 400727 39861 90187746
Disease recurrence 13.11 9.71 105 400735 37548 90190059
Glycosylated haemoglobin increased 13.10 9.71 31 400809 15531 90212076
Deformity 13.06 9.71 21 400819 12149 90215458
Decubitus ulcer 13.04 9.71 20 400820 11793 90215814
Polyneuropathy 12.97 9.71 43 400797 19298 90208309
Haematochezia 12.96 9.71 408 400432 70505 90157102
Upper respiratory tract infection 12.90 9.71 451 400389 127867 90099740
Excessive skin 12.88 9.71 8 400832 136 90227471
Injection site haemorrhage 12.84 9.71 73 400767 28245 90199362
Bradykinesia 12.83 9.71 7 400833 6781 90220826
Actinomycotic sepsis 12.78 9.71 10 400830 250 90227357
Device deployment issue 12.78 9.71 3 400837 4906 90222701
Cardiomegaly 12.74 9.71 42 400798 18883 90208724
Eosinophil count increased 12.74 9.71 24 400816 13057 90214550
Skin lesion 12.64 9.71 105 400735 37260 90190347
Device breakage 12.62 9.71 27 400813 14017 90213590
Drug dependence 12.56 9.71 77 400763 29250 90198357
Wrist fracture 12.47 9.71 32 400808 15592 90212015
Haemoglobin abnormal 12.46 9.71 8 400832 7092 90220515
Tension headache 12.46 9.71 9 400831 7500 90220107
Eye pain 12.41 9.71 130 400710 44038 90183569
Renal cyst 12.40 9.71 24 400816 12926 90214681
Somnambulism 12.40 9.71 6 400834 6222 90221385
Blood pressure inadequately controlled 12.39 9.71 6 400834 6218 90221389
Troponin increased 12.39 9.71 25 400815 13256 90214351
Transfusion 12.34 9.71 38 400802 17450 90210157
Gastroenteritis viral 12.33 9.71 81 400759 30274 90197333
Euglycaemic diabetic ketoacidosis 12.31 9.71 6 400834 6195 90221412
Sinusitis fungal 12.31 9.71 27 400813 1937 90225670
Airway peak pressure increased 12.29 9.71 12 400828 406 90227201
Red blood cell sedimentation rate increased 12.28 9.71 464 400376 82131 90145476
Dyslipidaemia 12.26 9.71 16 400824 10091 90217516
Off label use 12.21 9.71 5222 395618 1097030 89130577
Cortisol increased 12.11 9.71 13 400827 493 90227114
Perioral dermatitis 12.11 9.71 14 400826 577 90227030
Injection site urticaria 12.11 9.71 40 400800 17971 90209636
Metastasis 12.09 9.71 6 400834 6131 90221476
Wheelchair user 12.07 9.71 10 400830 7775 90219832
Hyperemesis gravidarum 12.03 9.71 16 400824 762 90226845
Pneumonia bacterial 11.99 9.71 24 400816 12766 90214841
Gastroenteritis norovirus 11.98 9.71 30 400810 2346 90225261
Post transplant lymphoproliferative disorder 11.97 9.71 8 400832 6941 90220666
Blood pressure systolic decreased 11.96 9.71 14 400826 9256 90218351
Hypothalamo-pituitary disorder 11.95 9.71 29 400811 2223 90225384
Cardiac failure chronic 11.93 9.71 5 400835 5641 90221966
Brain injury 11.92 9.71 10 400830 7728 90219879
Pre-eclampsia 11.92 9.71 19 400821 11029 90216578
Impaired driving ability 11.90 9.71 4 400836 5169 90222438
Oral herpes 11.90 9.71 93 400747 33431 90194176
Hallucination, visual 11.89 9.71 57 400783 23035 90204572
Injection site haematoma 11.88 9.71 8 400832 6914 90220693
Gastric polyps 11.88 9.71 3 400837 4669 90222938
Feeling jittery 11.87 9.71 32 400808 15339 90212268
Coma scale abnormal 11.86 9.71 5 400835 5621 90221986
Sinus bradycardia 11.85 9.71 37 400803 16915 90210692
Haemorrhagic stroke 11.85 9.71 7 400833 6489 90221118
Maternal drugs affecting foetus 11.84 9.71 4 400836 5151 90222456
Pulmonary congestion 11.83 9.71 45 400795 19388 90208219
Tendon pain 11.81 9.71 40 400800 3708 90223899
Pleurisy 11.80 9.71 14 400826 9203 90218404
Vitamin D deficiency 11.79 9.71 39 400801 17517 90210090
Hiatus hernia 11.71 9.71 65 400775 25296 90202311
Feeding disorder 11.70 9.71 39 400801 17473 90210134
Peripheral arterial occlusive disease 11.68 9.71 3 400837 4618 90222989
Hepatomegaly 11.66 9.71 26 400814 13300 90214307
Rotator cuff syndrome 11.66 9.71 34 400806 15885 90211722
Normochromic normocytic anaemia 11.65 9.71 4 400836 5098 90222509
Death neonatal 11.62 9.71 28 400812 2137 90225470
Muscle spasticity 11.62 9.71 100 400740 35222 90192385
Deafness neurosensory 11.62 9.71 8 400832 6833 90220774
Blood growth hormone increased 11.61 9.71 13 400827 517 90227090
Atrial tachycardia 11.58 9.71 6 400834 5984 90221623
Ligament sprain 11.58 9.71 30 400810 14569 90213038
Gastrointestinal scarring 11.57 9.71 12 400828 437 90227170
Abnormal loss of weight 11.56 9.71 8 400832 6815 90220792
Device use error 11.54 9.71 9 400831 7212 90220395
Limb discomfort 11.54 9.71 110 400730 37950 90189657
Small intestine gangrene 11.54 9.71 5 400835 38 90227569
Liver function test increased 11.52 9.71 472 400368 84383 90143224
Pregnancy with contraceptive device 11.52 9.71 4 400836 5062 90222545
Immune system disorder 11.46 9.71 22 400818 11883 90215724
Product substitution issue 11.42 9.71 41 400799 17967 90209640
Skin fragility 11.40 9.71 17 400823 901 90226706
Presyncope 11.39 9.71 88 400752 31717 90195890
Cerebral microangiopathy 11.38 9.71 10 400830 295 90227312
Genital haemorrhage 11.38 9.71 13 400827 8689 90218918
Eyelid oedema 11.38 9.71 21 400819 11513 90216094
Pulmonary toxicity 11.37 9.71 21 400819 11510 90216097
Pericardial effusion 11.36 9.71 106 400734 36727 90190880
Status epilepticus 11.30 9.71 44 400796 18830 90208777
Ageusia 11.30 9.71 35 400805 16041 90211566
Cholecystitis acute 11.30 9.71 15 400825 9389 90218218
Acute coronary syndrome 11.29 9.71 19 400821 10794 90216813
Herpes zoster infection neurological 11.28 9.71 13 400827 534 90227073
Rash pruritic 11.26 9.71 277 400563 81937 90145670
Squamous cell carcinoma 11.25 9.71 17 400823 10084 90217523
Defaecation urgency 11.22 9.71 56 400784 6186 90221421
Hereditary angioedema 11.19 9.71 15 400825 9350 90218257
Glioblastoma multiforme 11.13 9.71 17 400823 921 90226686
Seasonal allergy 11.11 9.71 58 400782 22925 90204682
Anal fistula 11.09 9.71 43 400797 4258 90223349
Respiratory disorder 11.09 9.71 370 400470 64446 90163161
Dysuria 11.06 9.71 116 400724 39285 90188322
Blood sodium decreased 11.06 9.71 74 400766 27539 90200068
Dental caries 11.02 9.71 21 400819 11376 90216231
Urine viscosity increased 11.01 9.71 5 400835 43 90227564
Fluid retention 10.95 9.71 301 400539 87790 90139817
Gout 10.95 9.71 38 400802 16821 90210786
Premature delivery 10.93 9.71 114 400726 38648 90188959
Mastocytosis 10.88 9.71 17 400823 939 90226668
Peripheral sensory neuropathy 10.86 9.71 15 400825 9235 90218372
Ventricular hypokinesia 10.86 9.71 5 400835 5336 90222271
Catarrh 10.85 9.71 23 400817 1611 90225996
Dialysis 10.85 9.71 21 400819 11308 90216299
Blood glucose decreased 10.84 9.71 60 400780 23369 90204238
Medication error 10.84 9.71 468 400372 84184 90143423
Serum ferritin increased 10.82 9.71 10 400830 7371 90220236
Brachycephaly 10.79 9.71 4 400836 19 90227588
Kidney transplant rejection 10.76 9.71 4 400836 4853 90222754
Hepatic failure 10.73 9.71 118 400722 39610 90187997
Tuberculosis gastrointestinal 10.73 9.71 11 400829 395 90227212
Congestive cardiomyopathy 10.73 9.71 10 400830 7344 90220263
Eye disorder 10.67 9.71 74 400766 27316 90200291
Varicose vein 10.65 9.71 10 400830 7317 90220290
Crying 10.64 9.71 68 400772 25577 90202030
Oral mucosal blistering 10.60 9.71 9 400831 6915 90220692
Post procedural haemorrhage 10.60 9.71 14 400826 8784 90218823
Sleep disorder due to a general medical condition 10.58 9.71 266 400574 44472 90183135
Aortic arteriosclerosis 10.58 9.71 11 400829 7673 90219934
Sexual dysfunction 10.57 9.71 4 400836 4800 90222807
Ventricular arrhythmia 10.56 9.71 3 400837 4318 90223289
Eye pruritus 10.55 9.71 80 400760 28947 90198660
Cardiac murmur 10.52 9.71 43 400797 18151 90209456
Pituitary haemorrhage 10.49 9.71 6 400834 87 90227520
Uterine cyst 10.49 9.71 12 400828 489 90227118
Shared psychotic disorder 10.46 9.71 4 400836 21 90227586
Tooth extraction 10.46 9.71 22 400818 11491 90216116
Stress 10.41 9.71 277 400563 81118 90146489
Performance status decreased 10.40 9.71 3 400837 4277 90223330
Mixed liver injury 10.40 9.71 11 400829 7612 90219995
Pharyngeal oedema 10.39 9.71 29 400811 13742 90213865
Neutropenic infection 10.37 9.71 24 400816 1785 90225822
Aborted pregnancy 10.36 9.71 5 400835 50 90227557
Photosensitivity reaction 10.35 9.71 42 400798 17765 90209842
Joint stiffness 10.34 9.71 433 400407 77609 90149998
Swollen tongue 10.34 9.71 142 400698 45814 90181793
Anger 10.27 9.71 29 400811 13691 90213916
Left ventricular dysfunction 10.26 9.71 32 400808 14637 90212970
Cerebral ischaemia 10.25 9.71 10 400830 7186 90220421
Glaucoma 10.25 9.71 52 400788 20703 90206904
Renal function test abnormal 10.24 9.71 10 400830 7181 90220426
Pseudohypoaldosteronism 10.19 9.71 5 400835 52 90227555
Oedema peripheral 10.18 9.71 992 399848 256923 89970684
Anticipatory anxiety 10.17 9.71 19 400821 1214 90226393
Lung adenocarcinoma 10.15 9.71 6 400834 5559 90222048
Tachycardia 10.14 9.71 582 400258 157091 90070516
Bipolar disorder 10.13 9.71 15 400825 8970 90218637
Immunosuppressant drug level increased 10.12 9.71 4 400836 4676 90222931
Brain oedema 10.11 9.71 41 400799 17344 90210263
Injection site discolouration 10.08 9.71 16 400824 9304 90218303
Unmasking of previously unidentified disease 10.07 9.71 21 400819 1455 90226152
Bradypnoea 10.05 9.71 4 400836 4654 90222953
Renal cancer 10.03 9.71 7 400833 5938 90221669
Anorectal ulcer 10.03 9.71 5 400835 54 90227553
Device leakage 10.02 9.71 18 400822 9973 90217634
Fatigue 10.00 9.71 4790 396050 1149233 89078374
Non-cardiac chest pain 9.97 9.71 9 400831 6712 90220895
Hepatocellular injury 9.97 9.71 81 400759 28877 90198730
Central nervous system lesion 9.97 9.71 23 400817 11623 90215984
Adrenocortical carcinoma 9.95 9.71 5 400835 55 90227552
Breast cancer recurrent 9.94 9.71 6 400834 5497 90222110
Limb deformity 9.93 9.71 3 400837 4149 90223458
Device related infection 9.88 9.71 70 400770 25716 90201891
Paranoia 9.87 9.71 27 400813 12881 90214726
Intestinal ischaemia 9.85 9.71 15 400825 8868 90218739
Product preparation error 9.84 9.71 19 400821 10242 90217365
Nocturia 9.83 9.71 19 400821 10236 90217371
Neutrophilic panniculitis 9.79 9.71 5 400835 57 90227550
Pus in stool 9.79 9.71 5 400835 57 90227550
Non-consummation 9.79 9.71 5 400835 57 90227550
Diabetic neuropathy 9.75 9.71 4 400836 4570 90223037
Complication of device removal 9.74 9.71 8 400832 6247 90221360

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional product use issue 292.80 10.23 626 117009 71207 42432493
Adrenal insufficiency 289.26 10.23 307 117328 18617 42485083
Toxicity to various agents 248.01 10.23 164 117471 228972 42274728
Drug abuse 245.86 10.23 10 117625 104761 42398939
Adrenocortical insufficiency acute 222.77 10.23 113 117522 2102 42501598
Death 209.29 10.23 639 116996 470546 42033154
Blood pressure fluctuation 208.90 10.23 311 117324 26597 42477103
Completed suicide 205.52 10.23 16 117619 96449 42407251
Frequent bowel movements 169.87 10.23 250 117385 21157 42482543
Craniopharyngioma 166.03 10.23 51 117584 215 42503485
Condition aggravated 154.93 10.23 1239 116396 259515 42244185
Bronchiectasis 146.68 10.23 213 117422 17806 42485894
Inappropriate schedule of product administration 146.46 10.23 588 117047 95314 42408386
Infusion related reaction 138.00 10.23 425 117210 60381 42443319
Adrenal suppression 132.69 10.23 61 117574 904 42502796
Graft loss 129.46 10.23 59 117576 856 42502844
Off label use 122.75 10.23 2453 115182 635882 41867818
Colitis ulcerative 112.20 10.23 233 117402 25942 42477758
Serum sickness 99.27 10.23 67 117568 2158 42501542
Febrile bone marrow aplasia 98.81 10.23 131 117504 10050 42493650
Diabetes insipidus 98.80 10.23 82 117553 3631 42500069
Impaired quality of life 93.45 10.23 152 117483 14025 42489675
Intentional overdose 93.37 10.23 15 117620 51441 42452259
Drug interaction 93.00 10.23 400 117235 266599 42237101
Steroid dependence 92.14 10.23 103 117532 6619 42497081
Eczema 86.57 10.23 248 117387 33838 42469862
Heart rate decreased 86.28 10.23 259 117376 36273 42467427
Overdose 85.10 10.23 99 117536 105165 42398535
Hypofibrinogenaemia 80.12 10.23 56 117579 1911 42501789
Interstitial lung disease 79.65 10.23 60 117575 78402 42425298
Faecal calprotectin increased 75.48 10.23 65 117570 3029 42500671
Hypopituitarism 75.02 10.23 62 117573 2729 42500971
Aplastic anaemia 73.91 10.23 127 117508 12257 42491443
Drug level below therapeutic 71.01 10.23 89 117546 6456 42497244
Stress 69.76 10.23 274 117361 43938 42459762
Heart rate irregular 68.92 10.23 143 117492 15907 42487793
Acute kidney injury 66.82 10.23 670 116965 366667 42137033
Fall 66.27 10.23 378 117257 234142 42269558
Dermatitis atopic 66.03 10.23 121 117514 12283 42491417
Leukoencephalopathy 64.65 10.23 74 117561 4880 42498820
Pituitary tumour benign 64.34 10.23 38 117597 964 42502736
Burns second degree 63.14 10.23 81 117554 6015 42497685
Catarrh 62.73 10.23 80 117555 5906 42497794
Febrile neutropenia 61.65 10.23 783 116852 184920 42318780
Suicide attempt 58.42 10.23 27 117608 46073 42457627
Drug ineffective 57.39 10.23 2201 115434 627996 41875704
Gingival pain 57.25 10.23 92 117543 8402 42495298
Steroid withdrawal syndrome 56.95 10.23 24 117611 285 42503415
Cortisol decreased 55.59 10.23 39 117596 1339 42502361
Parosmia 55.57 10.23 86 117549 7605 42496095
Hypopnoea 55.36 10.23 87 117548 7795 42495905
Anal inflammation 54.73 10.23 47 117588 2182 42501518
Drug specific antibody present 54.25 10.23 61 117574 3945 42499755
Systemic lupus erythematosus 53.53 10.23 94 117541 9230 42494470
Sedation 52.84 10.23 10 117625 30465 42473235
Insulin-like growth factor decreased 52.68 10.23 22 117613 255 42503445
Impaired work ability 52.23 10.23 108 117527 11983 42491717
Body temperature fluctuation 51.54 10.23 40 117595 1607 42502093
Gingival disorder 50.94 10.23 39 117596 1535 42502165
Myocardial infarction 50.67 10.23 174 117461 123835 42379865
Mucosal inflammation 47.59 10.23 265 117370 49109 42454591
Atrial fibrillation 46.76 10.23 212 117423 139381 42364319
Erythema 45.58 10.23 480 117155 108313 42395387
Cardiac failure 44.97 10.23 148 117487 106708 42396992
Gastrointestinal haemorrhage 44.93 10.23 130 117505 97596 42406104
Renal impairment 44.80 10.23 155 117480 110073 42393627
Hypertriglyceridaemia 43.22 10.23 90 117545 10036 42493664
Hypophysitis 42.75 10.23 47 117588 2964 42500736
Fistula 41.89 10.23 77 117558 7835 42495865
Analgesic therapy 41.71 10.23 69 117566 6455 42497245
Soft tissue mass 41.66 10.23 29 117606 983 42502717
Tendon disorder 41.51 10.23 49 117586 3340 42500360
Insulin-like growth factor increased 41.29 10.23 35 117600 1596 42502104
Drug hypersensitivity 40.92 10.23 437 117198 98952 42404748
Tendon pain 40.89 10.23 48 117587 3252 42500448
Disease progression 40.27 10.23 232 117403 143424 42360276
Anaemia 40.06 10.23 539 117096 279739 42223961
Bronchopulmonary aspergillosis allergic 39.83 10.23 56 117579 4542 42499158
Haematochezia 39.18 10.23 286 117349 58150 42445550
Congenital hiatus hernia 39.07 10.23 65 117570 6109 42497591
Sleep disorder therapy 38.93 10.23 69 117566 6825 42496875
Multimorbidity 38.92 10.23 27 117608 910 42502790
Platelet count decreased 38.74 10.23 224 117411 138357 42365343
Rhinitis 38.36 10.23 95 117540 11882 42491818
Neuralgia 37.30 10.23 155 117480 25492 42478208
Arthralgia 37.14 10.23 783 116852 204455 42299245
Hallucination 36.63 10.23 64 117571 57443 42446257
Oesophageal perforation 36.54 10.23 29 117606 1204 42502496
Flushing 36.52 10.23 200 117435 36828 42466872
Glioblastoma multiforme 35.67 10.23 25 117610 857 42502843
Blood pressure increased 35.15 10.23 433 117202 101495 42402205
Oral disorder 35.03 10.23 54 117581 4758 42498942
SARS-CoV-2 test negative 34.85 10.23 33 117602 1742 42501958
Pituitary haemorrhage 34.18 10.23 15 117620 198 42503502
Secondary adrenocortical insufficiency 33.75 10.23 35 117600 2064 42501636
Electrocardiogram QT prolonged 33.69 10.23 50 117585 47895 42455805
Anal fistula 33.57 10.23 61 117574 6152 42497548
White blood cell count decreased 33.28 10.23 174 117461 110222 42393478
Anal fissure 32.95 10.23 55 117580 5184 42498516
Pseudostroke 32.86 10.23 12 117623 94 42503606
Cardio-respiratory arrest 32.37 10.23 71 117564 58565 42445135
Tendon rupture 32.36 10.23 70 117565 8013 42495687
Renal failure 32.29 10.23 248 117387 143478 42360222
Glioma 32.00 10.23 19 117616 487 42503213
Extrapyramidal disorder 31.60 10.23 4 117631 16408 42487292
Cardiac murmur 31.51 10.23 92 117543 12683 42491017
Pneumoretroperitoneum 31.49 10.23 13 117622 146 42503554
Hospitalisation 31.23 10.23 103 117532 74227 42429473
Rectal haemorrhage 30.55 10.23 238 117397 49368 42454332
Antacid therapy 30.31 10.23 50 117585 4667 42499033
Epiphysiolysis 30.21 10.23 12 117623 121 42503579
Drug therapy 29.96 10.23 59 117576 6321 42497379
Migraine 29.74 10.23 144 117491 25270 42478430
Drug level decreased 29.73 10.23 77 117558 9900 42493800
Product use issue 29.53 10.23 333 117302 76418 42427282
Septic shock 29.29 10.23 384 117251 91288 42412412
Poor venous access 29.26 10.23 63 117572 7189 42496511
Aggression 29.18 10.23 48 117587 44115 42459585
Anticoagulant therapy 29.04 10.23 48 117587 4487 42499213
Angina pectoris 28.71 10.23 29 117606 32867 42470833
Rash 28.60 10.23 982 116653 275972 42227728
Hypophosphataemia 28.46 10.23 124 117511 20821 42482879
Crohn's disease 28.35 10.23 38 117597 2946 42500754
Neoplasm recurrence 27.90 10.23 36 117599 2688 42501012
Growth retardation 27.88 10.23 34 117601 2398 42501302
Hypogonadism 27.86 10.23 34 117601 2400 42501300
Coma 27.83 10.23 67 117568 53487 42450213
Blood growth hormone increased 27.80 10.23 19 117616 625 42503075
Posterior reversible encephalopathy syndrome 27.57 10.23 88 117547 12733 42490967
Shunt malfunction 27.28 10.23 14 117621 267 42503433
Skin exfoliation 27.06 10.23 202 117433 41351 42462349
Hyperphosphataemia 26.83 10.23 88 117547 12916 42490784
Swollen tongue 26.82 10.23 123 117512 21108 42482592
Proctalgia 26.78 10.23 60 117575 7033 42496667
Cerebellar tumour 26.61 10.23 11 117624 124 42503576
Blood growth hormone decreased 26.58 10.23 8 117627 31 42503669
Respiratory disorder 26.47 10.23 126 117509 21959 42481741
Myasthenia gravis 26.25 10.23 101 117534 16036 42487664
Transplant failure 26.16 10.23 43 117592 4001 42499699
Thyrotoxic periodic paralysis 26.09 10.23 12 117623 178 42503522
Thermophobia 26.02 10.23 9 117626 59 42503641
Thyroxine free decreased 25.99 10.23 14 117621 296 42503404
Subdural haematoma 25.73 10.23 16 117619 23122 42480578
Superinfection 25.65 10.23 36 117599 2915 42500785
Idiopathic intracranial hypertension 25.63 10.23 20 117615 810 42502890
Pelvic abscess 25.59 10.23 22 117613 1023 42502677
Therapeutic response shortened 25.56 10.23 89 117546 13465 42490235
Pneumonia 25.52 10.23 931 116704 421218 42082482
Malignant neoplasm progression 25.31 10.23 185 117450 108215 42395485
Multiple organ dysfunction syndrome 25.22 10.23 392 117243 96643 42407057
Neuroleptic malignant syndrome 25.07 10.23 14 117621 21458 42482242
Body temperature increased 25.02 10.23 117 117518 20241 42483459
Rash erythematous 25.02 10.23 163 117472 31928 42471772
Chills 24.83 10.23 381 117254 93685 42410015
Hypertrophic cardiomyopathy 24.59 10.23 25 117610 1440 42502260
Symptom masked 24.58 10.23 20 117615 861 42502839
Cerebral candidiasis 24.48 10.23 9 117626 72 42503628
Tinnitus 24.43 10.23 150 117485 28788 42474912
Astrocytoma 24.41 10.23 12 117623 208 42503492
Abdominal pain 24.30 10.23 693 116942 189778 42313922
Weight increased 24.29 10.23 426 117209 107557 42396143
Respiratory depression 23.98 10.23 11 117624 18857 42484843
Respiratory moniliasis 23.96 10.23 13 117622 279 42503421
Bacterial infection 23.84 10.23 145 117490 27734 42475966
Chorioretinopathy 23.67 10.23 25 117610 1506 42502194
Lichen planus 23.67 10.23 23 117612 1254 42502446
Hyponatraemia 23.44 10.23 402 117233 101060 42402640
Myelopathy 23.27 10.23 34 117601 2857 42500843
Wrong technique in product usage process 23.23 10.23 52 117583 42583 42461117
Hyperkalaemia 23.03 10.23 129 117506 80329 42423371
Activated partial thromboplastin time prolonged 23.03 10.23 96 117539 15807 42487893
Blood pressure diastolic decreased 23.03 10.23 72 117563 10303 42493397
Suicidal ideation 22.91 10.23 63 117572 48098 42455602
Blood thyroid stimulating hormone decreased 22.71 10.23 30 117605 2293 42501407
Neutrophil count decreased 22.62 10.23 94 117541 63321 42440379
Delirium 22.59 10.23 72 117563 52447 42451253
Unmasking of previously unidentified disease 22.53 10.23 22 117613 1207 42502493
Breath sounds abnormal 22.45 10.23 79 117556 12014 42491686
Leukopenia 22.41 10.23 118 117517 74628 42429072
Rhabdomyolysis 22.38 10.23 125 117510 77894 42425806
Growth hormone-producing pituitary tumour 22.32 10.23 10 117625 139 42503561
Serotonin syndrome 22.31 10.23 23 117612 25822 42477878
Adrenocorticotropic hormone deficiency 22.31 10.23 23 117612 1347 42502353
Haemorrhoids 22.30 10.23 100 117535 16997 42486703
Alcohol poisoning 22.10 10.23 58 117577 7516 42496184
Cardiac failure congestive 22.01 10.23 142 117493 85460 42418240
Blood calcium increased 21.93 10.23 62 117573 8392 42495308
Total lung capacity decreased 21.81 10.23 37 117598 3533 42500167
Sepsis 21.62 10.23 711 116924 198623 42305077
Meningitis candida 21.58 10.23 10 117625 151 42503549
Intestinal intraepithelial lymphocytes increased 21.52 10.23 11 117624 208 42503492
Arthritis 21.22 10.23 193 117442 41872 42461828
Weight fluctuation 20.99 10.23 49 117586 5902 42497798
Blood creatine phosphokinase increased 20.98 10.23 66 117569 48272 42455428
Bradycardia 20.87 10.23 144 117491 85340 42418360
Anal abscess 20.78 10.23 58 117577 7792 42495908
Haemoglobin decreased 20.64 10.23 250 117385 132221 42371479
Pyrexia 20.62 10.23 1305 116330 392737 42110963
Primary adrenal insufficiency 20.33 10.23 12 117623 304 42503396
Strongyloidiasis 20.23 10.23 35 117600 3396 42500304
Colitis 20.20 10.23 207 117428 46365 42457335
Musculoskeletal injury 19.42 10.23 9 117626 136 42503564
Kounis syndrome 19.39 10.23 34 117601 3334 42500366
Body temperature decreased 19.33 10.23 85 117550 14328 42489372
Hydrocephalus 19.24 10.23 48 117587 6030 42497670
Arteriosclerosis 19.24 10.23 13 117622 17976 42485724
Weight decreased 19.14 10.23 728 116907 207220 42296480
Skin irritation 19.12 10.23 55 117580 7519 42496181
Cushingoid 19.00 10.23 34 117601 3388 42500312
Therapy interrupted 18.98 10.23 20 117615 22230 42481470
Melaena 18.94 10.23 50 117585 38696 42465004
Gastric hypomotility 18.80 10.23 10 117625 206 42503494
Chronic kidney disease 18.79 10.23 67 117568 47174 42456526
Cryptitis 18.59 10.23 11 117624 280 42503420
Feeling cold 18.54 10.23 78 117557 12895 42490805
Blood phosphorus increased 18.45 10.23 76 117559 12449 42491251
Cardiac disorder 18.42 10.23 71 117564 48861 42454839
Pulmonary alveolar haemorrhage 18.27 10.23 9 117626 14807 42488893
Loss of personal independence in daily activities 18.19 10.23 214 117421 49602 42454098
Syncope 18.11 10.23 181 117454 99225 42404475
Haematuria 18.03 10.23 90 117545 57709 42445991
Dizziness 18.02 10.23 537 117098 248717 42254983
Strabismus 18.01 10.23 27 117608 2321 42501379
Depressed level of consciousness 17.80 10.23 70 117565 47900 42455800
Microvillous inclusion disease 17.69 10.23 10 117625 233 42503467
Intentional self-injury 17.62 10.23 10 117625 15192 42488508
Bronchial haemorrhage 17.60 10.23 15 117620 689 42503011
Pleuritic pain 17.48 10.23 51 117584 7026 42496674
Pouchitis 17.42 10.23 17 117618 932 42502768
Shared psychotic disorder 17.35 10.23 5 117630 16 42503684
Bladder cancer 17.33 10.23 13 117622 17034 42486666
Prostate cancer 17.31 10.23 64 117571 44579 42459121
Hyponatraemic seizure 17.29 10.23 9 117626 177 42503523
Psychotic disorder 17.27 10.23 34 117601 29174 42474526
White blood cell count increased 17.24 10.23 65 117570 45022 42458678
Optic nerve disorder 17.16 10.23 15 117620 713 42502987
Pruritus 17.16 10.23 660 116975 188111 42315589
Blood glucose increased 17.09 10.23 126 117509 73573 42430127
Cerebral haemorrhage 17.06 10.23 53 117582 38913 42464787
Cerebral infarction 16.99 10.23 38 117597 31131 42472569
Cardiac failure chronic 16.97 10.23 3 117632 9598 42494102
Dry skin 16.93 10.23 206 117429 48132 42455568
Superior sagittal sinus thrombosis 16.93 10.23 11 117624 332 42503368
Renal disorder 16.91 10.23 34 117601 28946 42474754
Klebsiella infection 16.88 10.23 69 117566 11263 42492437
Hepatic function abnormal 16.84 10.23 79 117556 51488 42452212
Arteriosclerosis coronary artery 16.84 10.23 16 117619 18661 42485039
Periorbital infection 16.72 10.23 9 117626 190 42503510
Splenic peliosis 16.69 10.23 5 117630 19 42503681
Preterm premature rupture of membranes 16.62 10.23 7 117628 83 42503617
Drug reaction with eosinophilia and systemic symptoms 16.52 10.23 60 117575 42015 42461685
Product quality issue 16.50 10.23 15 117620 17867 42485833
Skin candida 16.36 10.23 14 117621 647 42503053
Product use in unapproved indication 16.32 10.23 643 116992 183813 42319887
Skin plaque 16.20 10.23 44 117591 5819 42497881
Pituitary tumour recurrent 16.18 10.23 7 117628 89 42503611
Meningitis tuberculous 16.03 10.23 14 117621 665 42503035
Aphthous ulcer 16.02 10.23 44 117591 5857 42497843
Dacryocanaliculitis 15.93 10.23 4 117631 6 42503694
Skin papilloma 15.82 10.23 28 117607 2766 42500934
Incorrect route of product administration 15.74 10.23 118 117517 24187 42479513
Thyroxine decreased 15.72 10.23 9 117626 215 42503485
Myelosuppression 15.69 10.23 58 117577 40403 42463297
Pituitary tumour 15.67 10.23 13 117622 575 42503125
Blood pressure diastolic increased 15.67 10.23 46 117589 6359 42497341
Appendicitis 15.64 10.23 104 117531 20509 42483191
Otitis media acute 15.63 10.23 14 117621 688 42503012
Mantle cell lymphoma stage III 15.59 10.23 5 117630 25 42503675
Lacrimal duct neoplasm 15.59 10.23 5 117630 25 42503675
Appendicolith 15.57 10.23 76 117559 13380 42490320
Parkinsonism 15.48 10.23 5 117630 10618 42493082
Probiotic therapy 15.48 10.23 8 117627 155 42503545
Stomatococcal infection 15.46 10.23 9 117626 222 42503478
Iron deficiency 15.42 10.23 66 117569 10995 42492705
Papule 15.38 10.23 43 117592 5783 42497917
Decreased appetite 15.25 10.23 411 117224 192726 42310974
Rales 15.11 10.23 67 117568 11333 42492367
Body height below normal 15.08 10.23 9 117626 233 42503467
Blood test abnormal 15.01 10.23 73 117562 12833 42490867
Leukaemia recurrent 15.01 10.23 22 117613 1854 42501846
Viral diarrhoea 14.98 10.23 10 117625 316 42503384
Lactic acidosis 14.98 10.23 69 117566 45192 42458508
Blood pressure systolic increased 14.97 10.23 130 117505 27838 42475862
Skin lesion 14.90 10.23 127 117508 27047 42476653
Hallucination, visual 14.69 10.23 22 117613 20998 42482702
Palpitations 14.67 10.23 209 117426 50588 42453112
Loss of consciousness 14.49 10.23 174 117461 92180 42411520
Pulmonary arterial hypertension 14.48 10.23 5 117630 10182 42493518
Posturing 14.46 10.23 12 117623 531 42503169
Lung neoplasm malignant 14.42 10.23 19 117616 19128 42484572
Brain neoplasm 14.40 10.23 31 117604 3537 42500163
Accident 14.31 10.23 45 117590 6458 42497242
Hallucination, auditory 14.28 10.23 12 117623 14852 42488848
Inflammatory marker increased 14.19 10.23 46 117589 6710 42496990
Addison's disease 14.07 10.23 4 117631 12 42503688
Congenital cardiovascular anomaly 14.05 10.23 8 117627 189 42503511
Chest pain 14.05 10.23 286 117349 139244 42364456
Pneumonia aspiration 13.95 10.23 81 117554 49997 42453703
Dermal cyst 13.92 10.23 22 117613 1981 42501719
Blood luteinising hormone decreased 13.91 10.23 7 117628 128 42503572
Cognitive disorder 13.90 10.23 48 117587 34124 42469576
Mineralocorticoid deficiency 13.83 10.23 4 117631 13 42503687
Encephalitis cytomegalovirus 13.68 10.23 17 117618 1222 42502478
Macule 13.66 10.23 22 117613 2013 42501687
Joint injury 13.62 10.23 78 117557 14598 42489102
Tooth injury 13.55 10.23 17 117618 1234 42502466
17-hydroxyprogesterone increased 13.39 10.23 4 117631 15 42503685
Gastrointestinal inflammation 13.23 10.23 35 117600 4557 42499143
Prothrombin level abnormal 13.17 10.23 6 117629 87 42503613
Diarrhoea haemorrhagic 13.16 10.23 49 117586 7658 42496042
Perineal pain 13.14 10.23 15 117620 986 42502714
Dry mouth 13.13 10.23 168 117467 39711 42463989
Atrial flutter 13.11 10.23 17 117618 17234 42486466
Underdose 13.11 10.23 16 117619 16650 42487050
Blood corticotrophin decreased 13.09 10.23 9 117626 299 42503401
Haematotoxicity 13.06 10.23 7 117628 10978 42492722
Back pain 12.95 10.23 496 117139 141280 42362420
Lower respiratory tract infection 12.90 10.23 172 117463 41034 42462666
Apnoeic attack 12.89 10.23 11 117624 506 42503194
Urticaria 12.88 10.23 281 117354 73755 42429945
Diffuse large B-cell lymphoma 12.83 10.23 5 117630 9449 42494251
Vestibular neuronitis 12.75 10.23 9 117626 312 42503388
Thrombocytopenia 12.75 10.23 414 117221 189865 42313835
Perioral dermatitis 12.72 10.23 8 117627 228 42503472
Pituitary infarction 12.64 10.23 4 117631 19 42503681
Adrenal insufficiency neonatal 12.62 10.23 3 117632 3 42503697
Asthenia 12.58 10.23 640 116995 280153 42223547
Haematemesis 12.57 10.23 42 117593 30157 42473543
Mucous stools 12.55 10.23 24 117611 2516 42501184
Blood corticotrophin increased 12.54 10.23 7 117628 159 42503541
Disturbance in sexual arousal 12.47 10.23 7 117628 161 42503539
Short-bowel syndrome 12.45 10.23 9 117626 324 42503376
Colitis microscopic 12.39 10.23 27 117608 3106 42500594
Anaplastic astrocytoma 12.36 10.23 6 117629 101 42503599
Stevens-Johnson syndrome 12.35 10.23 104 117531 22074 42481626
Glucocorticoid deficiency 12.34 10.23 11 117624 537 42503163
Allergic eosinophilia 12.29 10.23 5 117630 54 42503646
Micturition urgency 12.22 10.23 65 117570 11833 42491867
Eosinophilia 12.21 10.23 48 117587 32851 42470849
Tracheal injury 12.20 10.23 5 117630 55 42503645
Lip swelling 12.05 10.23 92 117543 18961 42484739
Cryptococcal fungaemia 11.98 10.23 7 117628 174 42503526
Therapy cessation 11.92 10.23 24 117611 20426 42483274
Normochromic normocytic anaemia 11.90 10.23 5 117630 9026 42494674
Anorectal disorder 11.87 10.23 16 117619 1247 42502453
Lung consolidation 11.87 10.23 43 117592 6634 42497066
Accidental exposure to product 11.83 10.23 24 117611 20369 42483331
Product prescribing error 11.80 10.23 35 117600 26077 42477623
Vasospasm 11.71 10.23 11 117624 575 42503125
Drug use disorder 11.69 10.23 7 117628 10326 42493374
Neurogenic bowel 11.66 10.23 7 117628 183 42503517
Neurotoxicity 11.66 10.23 108 117527 23543 42480157
Hypomagnesaemia 11.60 10.23 40 117595 28448 42475252
Apoptosis 11.60 10.23 11 117624 582 42503118
Cerebrospinal fluid leakage 11.59 10.23 12 117623 706 42502994
Miosis 11.57 10.23 12 117623 13434 42490266
Liver function test abnormal 11.56 10.23 48 117587 32343 42471357
Pharyngitis streptococcal 11.52 10.23 30 117605 3870 42499830
Unevaluable event 11.51 10.23 52 117583 34236 42469464
Medication error 11.48 10.23 141 117494 33013 42470687
Breath odour 11.46 10.23 14 117621 989 42502711
Clostridium difficile infection 11.44 10.23 104 117531 22555 42481145
Job dissatisfaction 11.43 10.23 7 117628 190 42503510
Blood androstenedione increased 11.41 10.23 3 117632 6 42503694
Congenital adrenal gland hypoplasia 11.41 10.23 3 117632 6 42503694
Administration site bruise 11.41 10.23 3 117632 6 42503694
Necrotising colitis 11.40 10.23 16 117619 1295 42502405
Metabolic acidosis 11.39 10.23 90 117545 51768 42451932
Coordination abnormal 11.36 10.23 4 117631 8046 42495654
Optic nerve operation 11.33 10.23 10 117625 482 42503218
Stress at work 11.29 10.23 8 117627 279 42503421
Neutropenia 11.29 10.23 443 117192 198988 42304712
Lymphocytic hypophysitis 11.27 10.23 9 117626 377 42503323
Pharyngitis bacterial 11.26 10.23 5 117630 68 42503632
Blood corticotrophin abnormal 11.22 10.23 4 117631 29 42503671
Type 1 diabetes mellitus 11.20 10.23 37 117598 5450 42498250
Fluid retention 11.19 10.23 47 117588 31572 42472128
Perirectal abscess 11.16 10.23 19 117616 1819 42501881
Device dislocation 11.13 10.23 47 117588 7784 42495916
Respiratory rate increased 11.07 10.23 60 117575 11002 42492698
Dyspnoea exertional 11.03 10.23 87 117548 50061 42453639
Blood uric acid increased 10.94 10.23 77 117558 15470 42488230
Neutrophil count increased 10.91 10.23 24 117611 19780 42483920
Rash pruritic 10.82 10.23 141 117494 33462 42470238
Eczema herpeticum 10.79 10.23 8 117627 300 42503400
Lichenification 10.78 10.23 10 117625 514 42503186
Upper gastrointestinal haemorrhage 10.75 10.23 45 117590 30254 42473446
Perineal infection 10.71 10.23 11 117624 641 42503059
Delusion 10.71 10.23 15 117620 14719 42488981
Immunosuppressant drug level increased 10.68 10.23 46 117589 7685 42496015
Dystrophic calcification 10.67 10.23 4 117631 34 42503666
Blood follicle stimulating hormone decreased 10.65 10.23 5 117630 78 42503622
Anhidrosis 10.63 10.23 7 117628 216 42503484
Blood potassium increased 10.60 10.23 22 117613 18514 42485186
Hyperbilirubinaemia 10.57 10.23 95 117540 20540 42483160
Meningitis bacterial 10.52 10.23 16 117619 1393 42502307
Gastric cancer 10.51 10.23 3 117632 6900 42496800
Functional gastrointestinal disorder 10.48 10.23 22 117613 2466 42501234
Hypothalamo-pituitary disorder 10.44 10.23 14 117621 1086 42502614
Fluid replacement 10.36 10.23 8 117627 319 42503381
Parakeratosis 10.33 10.23 7 117628 227 42503473
Renal tubular necrosis 10.31 10.23 22 117613 18332 42485368
Drug resistance 10.30 10.23 54 117581 34194 42469506
Abscess 10.28 10.23 71 117564 14177 42489523

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 866.88 9.84 397 431867 480158 109676877
Completed suicide 811.36 9.84 31 432233 242350 109914685
Duodenal ulcer perforation 729.54 9.84 1921 430343 175779 109981256
Wound 688.66 9.84 2249 430015 232188 109924847
Systemic lupus erythematosus 687.93 9.84 2373 429891 251965 109905070
Glossodynia 685.93 9.84 2167 430097 219837 109937198
Pericarditis 672.58 9.84 2134 430130 216980 109940055
Intentional product use issue 671.37 9.84 2314 429950 245592 109911443
Helicobacter infection 670.54 9.84 1890 430374 179987 109977048
Pemphigus 657.00 9.84 2088 430176 212482 109944553
Infusion related reaction 655.49 9.84 3088 429176 378074 109778961
Hand deformity 640.67 9.84 2095 430169 216411 109940624
Anti-cyclic citrullinated peptide antibody positive 627.25 9.84 1846 430418 180138 109976897
Drug abuse 596.06 9.84 22 432242 177389 109979646
Rheumatic fever 576.98 9.84 1396 430868 121183 110035852
Death 539.08 9.84 1210 431054 697659 109459376
Rheumatoid factor positive 533.93 9.84 1417 430847 130223 110026812
Drug interaction 524.67 9.84 713 431551 499470 109657565
Discomfort 496.35 9.84 1904 430360 212803 109944232
Folliculitis 463.29 9.84 1576 430688 166077 109990958
Synovitis 456.53 9.84 2201 430063 271891 109885144
Acute kidney injury 453.40 9.84 1146 431118 634284 109522751
Irritable bowel syndrome 448.78 9.84 1538 430726 162677 109994358
Blister 444.26 9.84 1914 430350 225462 109931573
Type 2 diabetes mellitus 443.16 9.84 1612 430652 175620 109981415
Adrenocortical insufficiency acute 442.34 9.84 253 432011 4187 110152848
Swollen joint count increased 436.38 9.84 992 431272 82669 110074366
Injury 386.89 9.84 1544 430720 175721 109981314
Swelling 379.47 9.84 2510 429754 348531 109808504
Muscle injury 376.18 9.84 1309 430955 139498 110017537
Hepatic enzyme increased 374.85 9.84 2340 429924 318552 109838483
Fibromyalgia 365.28 9.84 1479 430785 169430 109987605
Fall 365.22 9.84 1177 431087 602305 109554730
Ill-defined disorder 355.84 9.84 1383 430881 155470 110001565
Impaired healing 352.51 9.84 1614 430650 195103 109961932
Blood cholesterol increased 352.07 9.84 1544 430720 183241 109973794
Arthropathy 351.11 9.84 2121 430143 285401 109871634
Psoriatic arthropathy 347.13 9.84 1607 430657 195154 109961881
Facet joint syndrome 343.74 9.84 993 431271 95835 110061200
Sleep disorder due to general medical condition, insomnia type 342.40 9.84 1049 431215 104594 110052441
Abdominal discomfort 342.26 9.84 2672 429592 391186 109765849
Maternal exposure during pregnancy 341.52 9.84 1927 430337 252956 109904079
Alopecia 328.28 9.84 2495 429769 362258 109794777
Intentional overdose 324.55 9.84 62 432202 132439 110024596
Lip dry 319.89 9.84 989 431275 99094 110057941
Deep vein thrombosis postoperative 309.12 9.84 703 431561 58588 110098447
Adrenal insufficiency 302.60 9.84 572 431692 41818 110115217
Lower respiratory tract infection 299.05 9.84 1797 430467 241309 109915726
Anaemia 293.33 9.84 1123 431141 545963 109611072
Joint range of motion decreased 281 9.84 1080 431184 120752 110036283
Hypersensitivity 277.31 9.84 2601 429663 401397 109755638
Liver injury 264.88 9.84 1228 431036 149185 110007850
Autoimmune disorder 254.42 9.84 694 431570 64789 110092246
Lower limb fracture 243.01 9.84 747 431517 74601 110082434
C-reactive protein abnormal 240.37 9.84 1075 431189 128620 110028415
Live birth 235.50 9.84 701 431563 68783 110088252
Grip strength decreased 231.35 9.84 765 431499 79409 110077626
Atrial fibrillation 227.90 9.84 340 431924 229302 109927733
Overdose 227.35 9.84 351 431913 233443 109923592
Road traffic accident 225.87 9.84 925 431339 106473 110050562
Neutropenia 223.30 9.84 735 431529 373885 109783150
Interstitial lung disease 221.51 9.84 135 432129 139199 110017836
Colitis ulcerative 220.40 9.84 735 431529 76628 110080407
Adjustment disorder with depressed mood 213.05 9.84 506 431758 43377 110113658
Suicide attempt 211.54 9.84 70 432194 103324 110053711
Stomatitis 210.52 9.84 1789 430475 268453 109888582
Breast cancer stage III 206.45 9.84 730 431534 78387 110078648
Sleep disorder 205.76 9.84 1406 430858 197238 109959797
Frequent bowel movements 204.92 9.84 680 431584 70710 110086325
Condition aggravated 203.89 9.84 4016 428248 730820 109426215
Sciatica 198.41 9.84 801 431463 91598 110065437
Peripheral venous disease 196.66 9.84 749 431515 83368 110073667
Gastrointestinal disorder 194.96 9.84 1614 430650 240338 109916697
Dry mouth 194.05 9.84 1393 430871 198555 109958480
Disease progression 192.16 9.84 417 431847 243617 109913418
Platelet count decreased 189.66 9.84 384 431880 230059 109926976
Myocardial infarction 188.05 9.84 287 431977 191796 109965239
Sedation 187.74 9.84 25 432239 69658 110087377
Craniopharyngioma 186.41 9.84 66 432198 311 110156724
Product use issue 185.19 9.84 1948 430316 309747 109847288
Blood pressure fluctuation 184.70 9.84 678 431586 74146 110082889
Weight increased 184.65 9.84 2476 429788 417168 109739867
Coma 179.42 9.84 120 432144 117749 110039286
Renal impairment 177.43 9.84 289 431975 188156 109968879
White blood cell count decreased 177.29 9.84 396 431868 228994 109928041
Gait inability 177.19 9.84 1023 431241 135353 110021682
Mobility decreased 177.17 9.84 1557 430707 235865 109921170
Dislocation of vertebra 176.49 9.84 470 431794 43251 110113784
Bursitis 176.33 9.84 986 431278 128932 110028103
Cardiac failure 174.55 9.84 290 431974 187336 109969699
Drug intolerance 174.11 9.84 2387 429877 404125 109752910
Gastrointestinal haemorrhage 173.16 9.84 236 432028 165282 109991753
Hypercholesterolaemia 171.36 9.84 757 431507 90080 110066955
Contraindicated product administered 169.43 9.84 1597 430667 246670 109910365
Product dose omission issue 167.45 9.84 668 431596 321114 109835921
Steroid withdrawal syndrome 163.61 9.84 78 432186 867 110156168
Therapeutic product effect decreased 161.97 9.84 1562 430702 242754 109914281
Drug hypersensitivity 159.56 9.84 2577 429687 451513 109705522
Hip arthroplasty 156.96 9.84 528 431736 55285 110101750
Syncope 155.40 9.84 351 431913 202185 109954850
Haemoglobin decreased 154.42 9.84 479 431785 248248 109908787
Inappropriate schedule of product administration 154.28 9.84 1340 430924 202297 109954738
Hypotension 154.03 9.84 1308 430956 522541 109634494
Myelosuppression 151.91 9.84 90 432174 94250 110062785
Night sweats 151.20 9.84 969 431295 133014 110024021
Malignant neoplasm progression 150.46 9.84 283 431981 174284 109982751
Musculoskeletal stiffness 150.16 9.84 1714 430550 278108 109878927
Hypoaesthesia 147.76 9.84 1877 430387 312346 109844689
Wheezing 147.75 9.84 1587 430677 253643 109903392
Prescribed overdose 146.07 9.84 704 431560 86877 110070158
Wound infection 143.67 9.84 751 431513 95714 110061321
C-reactive protein 142.13 9.84 345 431919 29986 110127049
Joint swelling 141.57 9.84 2475 429789 440370 109716665
Cardio-respiratory arrest 140.51 9.84 147 432117 115689 110041346
Urticaria 139.61 9.84 1880 430384 316977 109840058
Electrocardiogram QT prolonged 137.04 9.84 134 432130 108826 110048209
Pneumonia 134.13 9.84 2517 429747 874197 109282838
Thrombocytopenia 133.15 9.84 808 431456 348077 109808958
Depressed level of consciousness 131.18 9.84 147 432117 112131 110044904
Lupus vulgaris 130.50 9.84 358 431906 33525 110123510
Renal failure 130.49 9.84 451 431813 226123 109930912
Exposure during pregnancy 129.57 9.84 1107 431157 166317 109990718
Contusion 129.51 9.84 1439 430825 231922 109925113
Inflammation 128.31 9.84 1236 431028 192002 109965033
Bradycardia 126.35 9.84 261 432003 155256 110001779
Cardiac failure congestive 124.74 9.84 251 432013 150749 110006286
X-ray abnormal 123.91 9.84 379 431885 37738 110119297
Cognitive disorder 122.88 9.84 97 432167 87414 110069621
Drug level below therapeutic 119.62 9.84 185 432079 11488 110145547
Migraine 118.97 9.84 1108 431156 170544 109986491
Osteoarthritis 115.34 9.84 1156 431108 181467 109975568
Onychomycosis 115.03 9.84 372 431892 38159 110118876
Leukopenia 113.19 9.84 259 432005 148532 110008503
Adverse event 110.14 9.84 766 431498 108043 110048992
Hyperkalaemia 109.39 9.84 229 432035 135567 110021468
Knee arthroplasty 108.96 9.84 523 431741 64425 110092610
Obesity 107.20 9.84 785 431479 112566 110044469
Rash 106.06 9.84 4065 428199 816899 109340136
Maternal exposure timing unspecified 106.02 9.84 246 432018 20767 110136268
Onychomadesis 104.58 9.84 404 431860 45259 110111776
Blood creatinine increased 103.98 9.84 366 431898 182523 109974512
Cardiac arrest 103.85 9.84 406 431858 196347 109960688
Neutrophil count decreased 103.38 9.84 197 432067 120744 110036291
Secondary immunodeficiency 102.15 9.84 108 432156 4568 110152467
Serotonin syndrome 101.66 9.84 52 432212 59101 110097934
Treatment failure 101.65 9.84 1585 430679 275649 109881386
Wrong technique in product usage process 101.34 9.84 115 432149 87233 110069802
Respiratory arrest 100.57 9.84 51 432213 58248 110098787
Product label confusion 98.93 9.84 251 432013 22426 110134609
Hepatic function abnormal 97.80 9.84 123 432141 89172 110067863
Diabetes insipidus 96.94 9.84 124 432140 6446 110150589
General physical health deterioration 96.88 9.84 2260 430004 423035 109734000
Poisoning 96.39 9.84 4 432260 29101 110127934
Blepharospasm 95.15 9.84 446 431818 54405 110102630
Nausea 94.98 9.84 3909 428355 1231781 108925254
Alanine aminotransferase increased 94.59 9.84 383 431881 183390 109973645
Melaena 94.30 9.84 78 432186 68679 110088356
Blood creatine phosphokinase increased 94.07 9.84 88 432176 72989 110084046
Suicidal ideation 92.25 9.84 140 432124 93797 110063238
Sinusitis 92.16 9.84 1651 430613 295037 109861998
Liver disorder 92.03 9.84 905 431359 141338 110015697
Intentional self-injury 90.60 9.84 18 432246 37411 110119624
Hyperhidrosis 90.45 9.84 400 431864 186898 109970137
Rhabdomyolysis 89.63 9.84 212 432052 120189 110036846
Nasopharyngitis 89.31 9.84 2094 430170 392267 109764768
Somnolence 88.52 9.84 740 431524 296709 109860326
Device expulsion 88.39 9.84 9 432255 30882 110126153
Off label use 87.85 9.84 6900 425364 1493285 108663750
Cerebrovascular accident 87.03 9.84 388 431876 180896 109976139
Pituitary tumour benign 86.97 9.84 79 432185 2768 110154267
Lung disorder 86.90 9.84 1081 431183 178966 109978069
Hallucination 86.88 9.84 165 432099 101267 110055768
Dyspepsia 86.85 9.84 1134 431130 189831 109967204
Loss of consciousness 85.56 9.84 435 431829 195871 109961164
Adverse drug reaction 85.38 9.84 705 431559 104854 110052181
Balance disorder 85.37 9.84 207 432057 116353 110040682
Oedema 84.14 9.84 1219 431045 208757 109948278
Pregnancy 82.63 9.84 407 431857 50660 110106375
Faecal calprotectin increased 82.58 9.84 116 432148 6603 110150432
Dehydration 82.44 9.84 697 431567 278814 109878221
Lactic acidosis 82.14 9.84 148 432116 92663 110064372
Anti-cyclic citrullinated peptide antibody 81.97 9.84 216 432048 19748 110137287
Hypopituitarism 81.34 9.84 93 432171 4297 110152738
Infection 81.31 9.84 1921 430343 360279 109796756
Haematuria 81.22 9.84 124 432140 82881 110074154
Neuroleptic malignant syndrome 81.16 9.84 17 432247 34042 110122993
Injection site pain 80.56 9.84 389 431875 177533 109979502
Retinitis 79.82 9.84 293 431971 32034 110125001
Metabolic acidosis 79.66 9.84 169 432095 99575 110057460
Secondary adrenocortical insufficiency 78.91 9.84 92 432172 4342 110152693
Agitation 77.98 9.84 207 432057 112844 110044191
Poisoning deliberate 77.12 9.84 7 432257 26324 110130711
Orthostatic hypotension 77.09 9.84 87 432177 66162 110090873
Steroid dependence 76.87 9.84 127 432137 8342 110148693
Injection site erythema 76.53 9.84 158 432106 94018 110063017
Aspartate aminotransferase increased 73.97 9.84 347 431917 159589 109997446
Abdominal pain upper 73.66 9.84 1836 430428 347275 109809760
Breast cancer stage II 72.61 9.84 254 432010 27121 110129914
Lupus-like syndrome 71.72 9.84 333 431931 40459 110116576
Chronic kidney disease 70.84 9.84 118 432146 76173 110080862
Blood glucose increased 70.16 9.84 273 431991 132223 110024812
Dysarthria 69.31 9.84 140 432124 83981 110073054
Therapy interrupted 68.97 9.84 56 432208 49766 110107269
Pancytopenia 68.61 9.84 508 431756 209105 109947930
Accidental exposure to product 68.25 9.84 57 432207 49951 110107084
Nail disorder 67.80 9.84 423 431841 57512 110099523
Respiratory depression 66.62 9.84 21 432243 31980 110125055
Pulmonary fibrosis 65.88 9.84 649 431615 101393 110055642
Hypertension 65.77 9.84 2526 429738 507558 109649477
Tremor 65.77 9.84 491 431773 201741 109955294
International normalised ratio increased 65.21 9.84 152 432112 86620 110070415
Arrhythmia 65.17 9.84 107 432157 69468 110087567
Feeling abnormal 65.03 9.84 426 431838 180285 109976750
Cough 64.74 9.84 1344 430920 460297 109696738
Parkinsonism 64.71 9.84 6 432258 22181 110134854
Epistaxis 64.41 9.84 276 431988 130096 110026939
Subdural haematoma 64.22 9.84 31 432233 36423 110120612
Hypomagnesaemia 64.21 9.84 85 432179 60285 110096750
Porphyria acute 64.12 9.84 190 432074 18590 110138445
Human bocavirus infection 63.95 9.84 45 432219 1083 110155952
Extrapyramidal disorder 63.67 9.84 17 432247 28850 110128185
Exostosis 62.46 9.84 349 431915 45607 110111428
Aggression 62.33 9.84 84 432180 59126 110097909
Cardiac disorder 61.96 9.84 128 432136 76152 110080883
Anal fissure 61.62 9.84 126 432138 9755 110147280
Dysphagia 61.58 9.84 350 431914 153250 110003785
Prescribed underdose 61.40 9.84 451 431813 64723 110092312
Acute myocardial infarction 61.17 9.84 149 432115 83628 110073407
Cerebral haemorrhage 60.78 9.84 100 432164 64868 110092167
Cerebral infarction 60.40 9.84 68 432196 51770 110105265
Upper gastrointestinal haemorrhage 60.26 9.84 64 432200 50032 110107003
Incorrect route of product administration 60.18 9.84 443 431821 63618 110093417
Body temperature fluctuation 60.11 9.84 74 432190 3699 110153336
Seizure 59.74 9.84 564 431700 220621 109936414
Myalgia 59.66 9.84 568 431696 221813 109935222
Full blood count abnormal 59.53 9.84 79 432185 55973 110101062
Cortisol decreased 59.30 9.84 64 432200 2772 110154263
Osteonecrosis of jaw 59.28 9.84 60 432204 47957 110109078
Pulmonary arterial hypertension 58.44 9.84 27 432237 32541 110124494
Drug reaction with eosinophilia and systemic symptoms 58.39 9.84 148 432116 81947 110075088
Fistula 58.27 9.84 161 432103 15138 110141897
Musculoskeletal pain 58.04 9.84 1022 431242 182001 109975034
Product prescribing error 58.01 9.84 69 432195 51262 110105773
Pleural effusion 58.00 9.84 431 431833 177278 109979757
Rheumatoid arthritis 57.58 9.84 824 431440 298789 109858246
Liver function test abnormal 57.45 9.84 114 432150 68836 110088199
Pneumonia aspiration 57.35 9.84 147 432117 81086 110075949
Drug resistance 57.32 9.84 82 432182 56292 110100743
Ulcer haemorrhage 56.93 9.84 206 432058 22365 110134670
Jaundice 56.52 9.84 90 432174 59146 110097889
Unevaluable event 56.50 9.84 90 432174 59137 110097898
Angina pectoris 56.33 9.84 98 432166 62197 110094838
Dyskinesia 56.19 9.84 71 432193 51375 110105660
Psychotic disorder 55.95 9.84 70 432194 50867 110106168
Intentional product misuse 55.93 9.84 298 431966 132606 110024429
Pulmonary hypertension 55.47 9.84 81 432183 55139 110101896
Therapy cessation 55.44 9.84 56 432208 44801 110112234
Mycobacterium chelonae infection 55.31 9.84 64 432200 2996 110154039
Eosinophilia 55.30 9.84 88 432176 57848 110099187
Constipation 54.87 9.84 1026 431238 356760 109800275
Injection site swelling 54.25 9.84 99 432165 61691 110095344
Urinary retention 54.04 9.84 120 432144 69563 110087472
Drug eruption 53.62 9.84 79 432185 53580 110103455
Lung neoplasm malignant 53.47 9.84 33 432231 33809 110123226
Multiple sclerosis relapse 53.16 9.84 71 432193 50169 110106866
Laryngitis 53.01 9.84 315 431949 42096 110114939
Hepatotoxicity 52.67 9.84 105 432159 63295 110093740
Bacterial infection 52.55 9.84 334 431930 45702 110111333
Drug specific antibody present 51.95 9.84 107 432157 8327 110148708
Schizophrenia 51.79 9.84 11 432253 21815 110135220
Agranulocytosis 51.55 9.84 102 432162 61658 110095377
Leukoencephalopathy 51.25 9.84 112 432152 9083 110147952
Walking aid user 51.14 9.84 214 432050 24861 110132174
Blood alkaline phosphatase increased 51.13 9.84 127 432137 70808 110086227
Blood bilirubin increased 50.96 9.84 141 432123 75831 110081204
Arthralgia 50.92 9.84 3619 428645 776013 109381022
Catarrh 49.90 9.84 97 432167 7238 110149797
Female genital tract fistula 49.77 9.84 160 432104 16359 110140676
Adrenal suppression 49.74 9.84 46 432218 1650 110155385
Aphasia 49.62 9.84 97 432167 58900 110098135
Myelodysplastic syndrome 49.60 9.84 44 432220 37440 110119595
Pulmonary oedema 49.17 9.84 214 432050 100445 110056590
Heart rate irregular 49.07 9.84 264 432000 34010 110123025
Epilepsy 48.90 9.84 603 431661 99606 110057429
Febrile bone marrow aplasia 48.90 9.84 165 432099 17300 110139735
Norovirus test positive 48.82 9.84 36 432228 934 110156101
Normal newborn 48.73 9.84 192 432072 21704 110135331
Hyperadrenocorticism 48.67 9.84 30 432234 573 110156462
Taste disorder 48.29 9.84 428 431836 64959 110092076
Altered state of consciousness 48.25 9.84 95 432169 57531 110099504
Back injury 48.13 9.84 334 431930 47065 110109970
Aplastic anaemia 47.67 9.84 205 432059 24103 110132932
Burns second degree 47.51 9.84 98 432166 7635 110149400
Finger deformity 47.45 9.84 255 432009 32837 110124198
Chronic sinusitis 47.25 9.84 209 432055 24875 110132160
Hypocalcaemia 47.14 9.84 117 432147 65249 110091786
Amnesia 47.09 9.84 624 431640 104784 110052251
Urinary tract infection 46.87 9.84 946 431318 325336 109831699
Hypercalcaemia 46.32 9.84 69 432195 46588 110110447
Diarrhoea 46.21 9.84 3831 428433 1135674 109021361
Herpes zoster 46.17 9.84 242 432022 108137 110048898
Skin ulcer 45.83 9.84 114 432150 63531 110093504
Pruritus 45.59 9.84 2742 429522 578818 109578217
Adverse reaction 45.15 9.84 232 432032 29362 110127673
Dyspnoea exertional 45.09 9.84 231 432033 103829 110053206
Metastases to bone 45.02 9.84 34 432230 31338 110125697
Ventricular tachycardia 44.92 9.84 79 432185 49930 110107105
Femur fracture 44.90 9.84 65 432199 44404 110112631
Anal inflammation 44.77 9.84 52 432212 2444 110154591
Hypofibrinogenaemia 44.59 9.84 52 432212 2455 110154580
Coeliac disease 44.25 9.84 305 431959 42882 110114153
Creatinine renal clearance decreased 44.21 9.84 15 432249 21800 110135235
Drug level decreased 44.03 9.84 166 432098 18382 110138653
Hypophysitis 43.61 9.84 77 432187 5338 110151697
Breast cancer 43.35 9.84 52 432212 38490 110118545
Insulin-like growth factor decreased 43.23 9.84 28 432236 585 110156450
Drug withdrawal syndrome 43.16 9.84 51 432213 38003 110119032
Blood potassium increased 42.84 9.84 40 432224 33209 110123826
Bladder cancer 42.81 9.84 13 432251 20279 110136756
Blood urea increased 42.32 9.84 95 432169 54862 110102173
Bone marrow failure 42.14 9.84 103 432161 57745 110099290
Mental status changes 42.14 9.84 154 432110 75968 110081067
COVID-19 41.95 9.84 689 431575 244371 109912664
Renal disorder 41.92 9.84 81 432183 49398 110107637
Hypoxia 41.83 9.84 315 431949 129200 110027835
Therapy partial responder 41.68 9.84 50 432214 37011 110120024
Miosis 41.39 9.84 17 432247 21966 110135069
Hallucination, auditory 41.35 9.84 26 432238 26371 110130664
Dyspnoea 41.35 9.84 3745 428519 1103127 109053908
Glioblastoma multiforme 40.99 9.84 39 432225 1451 110155584
Gamma-glutamyltransferase increased 40.96 9.84 114 432150 61195 110095840
Toxic skin eruption 40.55 9.84 29 432235 27486 110129549
Blood potassium decreased 40.49 9.84 95 432169 54019 110103016
Haematoma 40.37 9.84 107 432157 58369 110098666
Neoplasm recurrence 40.34 9.84 73 432191 5159 110151876
Haematotoxicity 40.18 9.84 16 432248 21066 110135969
Ischaemic stroke 40.02 9.84 62 432202 41201 110115834
Muscle rigidity 40.00 9.84 22 432242 24009 110133026
Plasma cell myeloma 39.88 9.84 120 432144 62816 110094219
Sedation complication 39.64 9.84 14 432250 19841 110137194
Cataract 39.42 9.84 168 432096 79317 110077718
Vision blurred 39.25 9.84 319 431945 128703 110028332
Pituitary haemorrhage 39.12 9.84 21 432243 305 110156730
Cystitis bacterial 38.73 9.84 35 432229 1218 110155817
Respiratory failure 38.66 9.84 600 431664 214732 109942303
Heart rate decreased 38.25 9.84 493 431771 82263 110074772
Vaginal discharge 38.23 9.84 155 432109 17753 110139282
Insulin-like growth factor increased 38.15 9.84 46 432218 2250 110154785
Dermatitis atopic 38.12 9.84 199 432065 25342 110131693
Cholestasis 38.08 9.84 127 432137 64391 110092644
Restlessness 38.04 9.84 104 432160 56155 110100880
Haematemesis 37.96 9.84 112 432152 58996 110098039
Atrial flutter 37.86 9.84 24 432240 24238 110132797
Confusional state 37.69 9.84 2215 430049 466465 109690570
Affect lability 37.45 9.84 13 432251 18624 110138411
Pulmonary alveolar haemorrhage 37.26 9.84 16 432248 20134 110136901
Cardiac failure chronic 37.09 9.84 5 432259 13806 110143229
Prostate cancer 37.05 9.84 56 432208 37585 110119450
Red blood cell count decreased 36.73 9.84 133 432131 65790 110091245
Panniculitis 36.67 9.84 8 432256 15574 110141461
Myoclonus 36.60 9.84 45 432219 32953 110124082
Blood calcium decreased 36.58 9.84 52 432212 35793 110121242
Bone erosion 36.58 9.84 308 431956 46063 110110972
Angioedema 36.54 9.84 230 432034 98270 110058765
Rheumatoid nodule 36.15 9.84 17 432247 20279 110136756
Proteinuria 36.14 9.84 63 432201 39955 110117080
Transplant rejection 36.06 9.84 26 432238 24541 110132494
Palmar-plantar erythrodysaesthesia syndrome 35.78 9.84 66 432198 40959 110116076
Diffuse large B-cell lymphoma 35.76 9.84 9 432255 15889 110141146
Transient ischaemic attack 35.71 9.84 129 432135 63853 110093182
Lymphocyte count decreased 35.66 9.84 110 432154 57133 110099902
Paraesthesia 35.49 9.84 1369 430895 275152 109881883
Back pain 35.21 9.84 1143 431121 369853 109787182
Thymus hypoplasia 35.15 9.84 38 432226 1649 110155386
Basal cell carcinoma 35.07 9.84 78 432186 45192 110111843
Right ventricular failure 34.90 9.84 30 432234 25924 110131111
Eczema 34.83 9.84 434 431830 71859 110085176
Seronegative arthritis 34.72 9.84 122 432142 13055 110143980
Disorientation 34.66 9.84 150 432114 70521 110086514
Red blood cell sedimentation rate abnormal 34.61 9.84 27 432237 24482 110132553
Chronic obstructive pulmonary disease 34.54 9.84 267 431997 108891 110048144
Poor venous access 34.51 9.84 188 432076 24334 110132701
Acute generalised exanthematous pustulosis 34.40 9.84 21 432243 21643 110135392
Memory impairment 34.16 9.84 1010 431254 195934 109961101
Rectal haemorrhage 34.09 9.84 658 431606 119175 110037860
Metastases to liver 33.53 9.84 54 432210 35332 110121703
Hepatocellular injury 33.22 9.84 95 432169 50547 110106488
Pseudostroke 33.16 9.84 16 432248 183 110156852
Human herpesvirus 6 infection 33.15 9.84 77 432187 6504 110150531
Device difficult to use 33.11 9.84 16 432248 18789 110138246
COVID-19 pneumonia 33.06 9.84 59 432205 37084 110119951
Granuloma skin 33.04 9.84 3 432261 11280 110145755
Pneumoretroperitoneum 32.93 9.84 16 432248 186 110156849
Coordination abnormal 32.92 9.84 30 432234 25198 110131837
Hemiparesis 32.91 9.84 77 432187 43826 110113209
Meningitis candida 32.86 9.84 17 432247 228 110156807
Therapeutic response shortened 32.76 9.84 213 432051 29370 110127665
Respiratory tract infection 32.74 9.84 156 432108 71461 110085574
Foetal death 32.57 9.84 11 432253 16034 110141001
Atrioventricular block complete 32.55 9.84 19 432245 20063 110136972
Vaginal flatulence 32.48 9.84 113 432151 12031 110145004
Mitral valve incompetence 32.40 9.84 50 432214 33279 110123756
Dystonia 32.13 9.84 32 432232 25773 110131262
Anal fistula 32.10 9.84 89 432175 8384 110148651
Lymphoid tissue hypoplasia 32.09 9.84 36 432228 1629 110155406
Glioma 31.86 9.84 27 432237 861 110156174
Atrioventricular block 31.86 9.84 13 432251 16864 110140171
Purpura 31.82 9.84 29 432235 24359 110132676
Mydriasis 31.81 9.84 24 432240 22133 110134902
Exposure to toxic agent 31.51 9.84 6 432258 12852 110144183
Delusion 31.29 9.84 28 432236 23727 110133308
Therapy non-responder 31.28 9.84 821 431443 156486 110000549
Adjustment disorder 31.27 9.84 3 432261 10792 110146243
Foot deformity 31.12 9.84 308 431956 48172 110108863
Proctalgia 31.11 9.84 118 432146 13104 110143931
Proctitis 31.10 9.84 140 432124 16787 110140248
Pituitary tumour recurrent 30.98 9.84 15 432249 173 110156862
Injection site bruising 30.88 9.84 100 432164 51163 110105872
Perfume sensitivity 30.86 9.84 29 432235 1062 110155973
Hypopnoea 30.53 9.84 106 432158 11274 110145761
Respiratory disorder 30.41 9.84 419 431845 70963 110086072
Normochromic normocytic anaemia 30.13 9.84 7 432257 13050 110143985
Pulmonary embolism 29.84 9.84 625 431639 213849 109943186
Hemiplegia 29.83 9.84 27 432237 22755 110134280
Haemorrhage 29.68 9.84 270 431994 106422 110050613
Abnormal behaviour 29.64 9.84 68 432196 38971 110118064
Diabetes mellitus inadequate control 29.59 9.84 44 432220 29731 110127304
Gingival pain 29.55 9.84 131 432133 15605 110141430
Growth retardation 29.42 9.84 43 432221 2539 110154496
Arteriosclerosis 29.39 9.84 32 432232 24735 110132300
Hallucination, visual 29.26 9.84 70 432194 39535 110117500
Hypothalamic pituitary adrenal axis suppression 29.23 9.84 23 432241 659 110156376
Bronchitis 29.06 9.84 435 431829 156597 110000438
Hepatic cytolysis 28.77 9.84 114 432150 54939 110102096
Cardiac failure acute 28.69 9.84 31 432233 24047 110132988
Sinus congestion 28.38 9.84 47 432217 30412 110126623
Coronary artery disease 28.38 9.84 164 432100 71526 110085509
Shock haemorrhagic 28.33 9.84 39 432225 27208 110129827
Gastric ulcer 28.16 9.84 72 432192 39755 110117280
Breast cancer female 28.15 9.84 7 432257 12461 110144574
Electrocardiogram QRS complex prolonged 28.10 9.84 8 432256 13013 110144022
Grip strength 27.96 9.84 89 432175 9052 110147983
Pneumonitis 27.72 9.84 180 432084 76351 110080684
Diabetic ketoacidosis 27.51 9.84 79 432185 41979 110115056
Ear infection 27.45 9.84 370 431894 62362 110094673
Unmasking of previously unidentified disease 27.38 9.84 44 432220 2824 110154211
Faecaloma 27.31 9.84 12 432252 14896 110142139
Acute hepatic failure 27.30 9.84 64 432200 36404 110120631
Head injury 27.27 9.84 82 432182 42935 110114100
Analgesic therapy 27.09 9.84 76 432188 7208 110149827
Carotid artery thrombosis 27.08 9.84 3 432261 9635 110147400
Strongyloidiasis 26.96 9.84 60 432204 4926 110152109
Asthenia 26.84 9.84 2323 429941 686676 109470359
Full blood count decreased 26.80 9.84 53 432211 32046 110124989
Blood corticotrophin decreased 26.78 9.84 24 432240 826 110156209
Astrocytoma 26.40 9.84 15 432249 245 110156790
Enthesopathy 26.31 9.84 8 432256 12470 110144565
Weight fluctuation 26.10 9.84 162 432102 21983 110135052
Perioral dermatitis 26.03 9.84 22 432242 699 110156336
Osteomyelitis 26.01 9.84 66 432198 36534 110120501
Angina unstable 25.99 9.84 16 432248 16416 110140619
Neuropathy peripheral 25.96 9.84 519 431745 178758 109978277
Sleep disorder therapy 25.90 9.84 76 432188 7395 110149640
Shared psychotic disorder 25.84 9.84 9 432255 40 110156995
Pseudomonal sepsis 25.80 9.84 86 432178 8960 110148075
Haematochezia 25.66 9.84 612 431652 114912 110042123
Generalised tonic-clonic seizure 25.65 9.84 118 432146 54562 110102473
Rib fracture 25.49 9.84 59 432205 33711 110123324
Hypervolaemia 25.48 9.84 103 432161 49357 110107678
Neoplasm progression 25.45 9.84 148 432116 64447 110092588
Metastases to central nervous system 25.43 9.84 31 432233 22786 110134249
Hypogonadism 25.37 9.84 35 432229 1959 110155076
Granulocytopenia 25.32 9.84 9 432255 12706 110144329
Hypokalaemia 25.28 9.84 532 431732 181916 109975119
Salpingo-oophorectomy unilateral 25.27 9.84 23 432241 808 110156227
Akathisia 25.27 9.84 18 432246 17095 110139940
Drug dependence 25.25 9.84 105 432159 49915 110107120
Gastric cancer 25.21 9.84 6 432258 11002 110146033
Atrioventricular block first degree 25.20 9.84 12 432252 14213 110142822
Colorectal cancer 25.20 9.84 3 432261 9111 110147924
Metastases to lung 25.01 9.84 32 432232 23031 110134004
Cardiomyopathy 24.97 9.84 59 432205 33466 110123569
Parosmia 24.96 9.84 110 432154 13070 110143965
Hepatitis acute 24.86 9.84 22 432242 18744 110138291
Subcutaneous drug absorption impaired 24.74 9.84 76 432188 7583 110149452
Nodule 24.64 9.84 57 432207 32574 110124461
Acute myeloid leukaemia 24.62 9.84 72 432192 38038 110118997
Eczema herpeticum 24.38 9.84 18 432246 468 110156567
Gangrene 24.37 9.84 17 432247 16324 110140711
Swollen joint count 24.33 9.84 82 432182 8592 110148443
Joint dislocation 24.32 9.84 222 432042 33968 110123067
Psychomotor hyperactivity 24.28 9.84 26 432238 20251 110136784
Apathy 24.08 9.84 17 432247 16222 110140813
Eating disorder 24.04 9.84 53 432211 30805 110126230
Glomerular filtration rate decreased 24.01 9.84 48 432216 28908 110128127
Congenital hiatus hernia 23.97 9.84 66 432198 6193 110150842
Fluid retention 23.96 9.84 244 432020 94063 110062972
Insomnia 23.49 9.84 1674 430590 358916 109798119
Duodenal ulcer 23.39 9.84 25 432239 19489 110137546
Dementia 23.38 9.84 56 432208 31617 110125418
Thrombosis 23.34 9.84 292 431972 108370 110048665
Palpitations 23.33 9.84 460 431804 158752 109998283
Deafness 23.26 9.84 43 432221 26666 110130369
Radiculopathy 23.14 9.84 142 432122 19194 110137841
Renal cancer 23.09 9.84 11 432253 13023 110144012
Leukocytosis 23.03 9.84 120 432144 53708 110103327
Blood pressure diastolic abnormal 22.98 9.84 41 432223 25774 110131261
Thermophobia 22.97 9.84 9 432255 59 110156976
Product administration error 22.84 9.84 72 432192 37145 110119890
Medication error 22.74 9.84 556 431708 104810 110052225
Soft tissue mass 22.72 9.84 29 432235 1504 110155531
Product use in unapproved indication 22.66 9.84 2037 430227 445340 109711695
Peripheral swelling 22.55 9.84 1853 430411 402181 109754854
Motor dysfunction 22.42 9.84 38 432226 24368 110132667
Haemorrhagic stroke 22.41 9.84 13 432251 13776 110143259
Electrocardiogram abnormal 22.39 9.84 24 432240 18685 110138350
Vasculitis 22.30 9.84 69 432195 35804 110121231
Overlap syndrome 22.27 9.84 82 432182 8977 110148058
Symptom masked 22.23 9.84 32 432232 1863 110155172
Multiple-drug resistance 22.20 9.84 12 432252 13223 110143812
Blood growth hormone increased 22.15 9.84 24 432240 1044 110155991
Natural killer-cell leukaemia 22.07 9.84 10 432254 98 110156937
Hyperreflexia 22.06 9.84 5 432259 9480 110147555
Hypoglycaemia 22.04 9.84 320 431944 115784 110041251
Hospitalisation 22.01 9.84 408 431856 142085 110014950
Cerebellar tumour 21.96 9.84 12 432252 181 110156854
Metastases to lymph nodes 21.95 9.84 16 432248 15016 110142019
Product storage error 21.70 9.84 32 432232 21696 110135339
Haemolytic anaemia 21.69 9.84 30 432234 20890 110136145
Ear pain 21.69 9.84 310 431954 52916 110104119
Tendon pain 21.59 9.84 64 432200 6262 110150773
Hepatic cirrhosis 21.55 9.84 378 431886 67248 110089787
Subarachnoid haemorrhage 21.54 9.84 53 432211 29649 110127386
Shunt malfunction 21.53 9.84 15 432249 355 110156680
Cerebral candidiasis 21.44 9.84 9 432255 72 110156963
Hypertensive crisis 21.44 9.84 39 432225 24333 110132702
Parainfluenzae virus infection 21.42 9.84 68 432196 6906 110150129
Dissociation 21.32 9.84 6 432258 9836 110147199
Renal injury 21.31 9.84 25 432239 18688 110138347
Multiple drug therapy 21.29 9.84 3 432261 8011 110149024
Rhinovirus infection 21.28 9.84 97 432167 11692 110145343
Systemic infection 21.25 9.84 6 432258 9813 110147222
Blindness 21.16 9.84 72 432192 36287 110120748
Hypophagia 21.04 9.84 120 432144 52506 110104529
Torsade de pointes 20.94 9.84 35 432229 22565 110134470
Dry eye 20.84 9.84 130 432134 55663 110101372
Skin toxicity 20.79 9.84 10 432254 11773 110145262
Complication associated with device 20.60 9.84 29 432235 20044 110136991
Ventricular hypokinesia 20.59 9.84 9 432255 11205 110145830
Epiphysiolysis 20.54 9.84 11 432253 159 110156876
Shock 20.46 9.84 124 432140 53464 110103571
Hepatic failure 20.42 9.84 171 432093 68568 110088467
Tardive dyskinesia 20.42 9.84 14 432250 13565 110143470
Hepatic cancer 20.41 9.84 9 432255 11147 110145888
Rhinitis allergic 20.35 9.84 24 432240 17898 110139137
Haematocrit decreased 20.32 9.84 163 432101 65954 110091081
Dysphonia 20.32 9.84 194 432070 75735 110081300
Hyponatraemia 20.29 9.84 672 431592 216981 109940054
Sinus tachycardia 20.29 9.84 97 432167 44396 110112639
Sarcoidosis 20.25 9.84 12 432252 12567 110144468
Pancreatic carcinoma 20.23 9.84 17 432247 14855 110142180
Drug tolerance decreased 20.19 9.84 180 432084 27360 110129675
Enterobacter infection 20.04 9.84 59 432205 5752 110151283
Drug level above therapeutic 19.93 9.84 94 432170 11494 110145541
Tongue disorder 19.88 9.84 16 432248 14282 110142753
Normal tension glaucoma 19.85 9.84 8 432256 57 110156978
Anaphylactic shock 19.83 9.84 119 432145 51427 110105608
Multimorbidity 19.82 9.84 27 432237 1493 110155542
Anal abscess 19.72 9.84 94 432170 11544 110145491
Cholelithiasis 19.66 9.84 156 432108 63266 110093769
Sinus bradycardia 19.56 9.84 55 432209 29428 110127607
Jaundice cholestatic 19.50 9.84 17 432247 14591 110142444
Paranoia 19.50 9.84 36 432228 22338 110134697
Oesophageal perforation 19.44 9.84 28 432236 1631 110155404
Mucous stools 19.44 9.84 65 432199 6782 110150253
Blood lactate dehydrogenase increased 19.44 9.84 98 432166 44236 110112799
Surgery 19.41 9.84 89 432175 41194 110115841
Renal tubular necrosis 19.38 9.84 58 432206 30417 110126618
Malaise 19.34 9.84 2950 429314 668869 109488166
Abscess bacterial 19.34 9.84 21 432243 916 110156119
Kounis syndrome 19.33 9.84 59 432205 5866 110151169
Skin necrosis 19.30 9.84 34 432230 21478 110135557
Antacid therapy 19.21 9.84 56 432208 5428 110151607
Abortion spontaneous 19.21 9.84 69 432195 34213 110122822
Labelled drug-drug interaction medication error 19.19 9.84 55 432209 29247 110127788
SARS-CoV-2 test negative 19.16 9.84 32 432232 2121 110154914
Eosinophil count increased 19.15 9.84 33 432231 21025 110136010
Splenomegaly 19.15 9.84 42 432222 24456 110132579
Neuritis 19.12 9.84 3 432261 7396 110149639
Urosepsis 19.07 9.84 59 432205 30616 110126419
Gingival bleeding 19.06 9.84 30 432234 19809 110137226
Withdrawal syndrome 19.05 9.84 61 432203 31319 110125716
Blood corticotrophin increased 19.02 9.84 13 432251 298 110156737
Eosinophilic granulomatosis with polyangiitis 18.96 9.84 9 432255 10677 110146358
Loss of employment 18.94 9.84 41 432223 3303 110153732
Pneumonia bacterial 18.94 9.84 47 432217 26214 110130821
Hepatitis C 18.86 9.84 13 432251 12560 110144475
Spondylitis 18.79 9.84 91 432173 11247 110145788
Urinary incontinence 18.78 9.84 112 432152 48475 110108560
Drug therapy 18.77 9.84 67 432197 7224 110149811
Vaginal haemorrhage 18.77 9.84 44 432220 25030 110132005
Influenza 18.76 9.84 510 431754 168591 109988444
Urticaria thermal 18.75 9.84 16 432248 515 110156520
Erythema nodosum 18.75 9.84 63 432201 6590 110150445
Growth hormone-producing pituitary tumour 18.64 9.84 10 432254 145 110156890
Neutrophil count increased 18.59 9.84 71 432193 34581 110122454
Hypothalamo-pituitary disorder 18.59 9.84 37 432227 2809 110154226
Thyrotoxic periodic paralysis 18.57 9.84 11 432253 195 110156840
Electrolyte imbalance 18.52 9.84 78 432186 36950 110120085
Viraemia 18.52 9.84 46 432218 4056 110152979
Treatment noncompliance 18.48 9.84 189 432075 72801 110084234
Pituitary infarction 18.44 9.84 8 432256 70 110156965
Nephropathy toxic 18.42 9.84 51 432213 27427 110129608
Ventricular extrasystoles 18.38 9.84 38 432226 22603 110134432
Psychomotor retardation 18.34 9.84 4 432260 7788 110149247
Personality disorder 18.31 9.84 14 432250 12823 110144212
Blood pressure systolic abnormal 18.29 9.84 44 432220 24806 110132229
Tenosynovitis 18.28 9.84 22 432242 16261 110140774
Hip fracture 18.24 9.84 73 432191 35078 110121957
Polyneuropathy 18.22 9.84 64 432200 31948 110125087
Abnormal dreams 18.15 9.84 14 432250 12766 110144269
Diplopia 18.14 9.84 93 432171 41801 110115234
Spinal stenosis 18.13 9.84 29 432235 19027 110138008
Musculoskeletal injury 18.13 9.84 11 432253 204 110156831
Defaecation urgency 18.11 9.84 75 432189 8672 110148363
Anticoagulant therapy 18.07 9.84 54 432210 5307 110151728
Salivary hypersecretion 18.05 9.84 25 432239 17396 110139639
Anhidrosis 17.95 9.84 14 432250 396 110156639
Psychomotor skills impaired 17.93 9.84 3 432261 7055 110149980
Arterial occlusive disease 17.92 9.84 20 432244 15288 110141747
Diverticulitis 17.84 9.84 129 432135 53393 110103642
Paradoxical drug reaction 17.83 9.84 8 432256 9809 110147226
Lethargy 17.73 9.84 258 432006 93318 110063717
Pain in jaw 17.72 9.84 122 432142 51055 110105980
Rectal spasm 17.71 9.84 11 432253 213 110156822
Presyncope 17.70 9.84 115 432149 48772 110108263
Bone disorder 17.68 9.84 35 432229 21157 110135878
Toxic encephalopathy 17.68 9.84 20 432244 15194 110141841
Nephropathy 17.59 9.84 16 432248 13451 110143584
Mental impairment 17.54 9.84 39 432225 22600 110134435
Hypomania 17.51 9.84 9 432255 10201 110146834
Dyslipidaemia 17.47 9.84 22 432242 15943 110141092
Death neonatal 17.46 9.84 27 432237 1676 110155359
Stenotrophomonas bacteraemia 17.45 9.84 12 432252 278 110156757
Pancreatitis acute 17.43 9.84 151 432113 60123 110096912
Petechiae 17.39 9.84 41 432223 23276 110133759
Injection site pruritus 17.35 9.84 123 432141 51135 110105900
Vertigo 17.35 9.84 237 432027 86633 110070402
Eye injury 17.26 9.84 68 432196 7687 110149348
Upper-airway cough syndrome 17.20 9.84 22 432242 15835 110141200
Bone pain 17.18 9.84 167 432097 64966 110092069
Internal haemorrhage 17.09 9.84 9 432255 10062 110146973
Unresponsive to stimuli 17.06 9.84 163 432101 63627 110093408
Protein urine present 17.06 9.84 12 432252 11472 110145563
Carotid artery occlusion 17.05 9.84 8 432256 9557 110147478
Sexual dysfunction 17.05 9.84 6 432258 8524 110148511
Speech disorder 17.04 9.84 156 432108 61413 110095622
Impaired quality of life 17.04 9.84 186 432078 29831 110127204
Injection site mass 17.02 9.84 45 432219 24568 110132467
Sickle cell anaemia with crisis 16.99 9.84 8 432256 9537 110147498
Sinus disorder 16.96 9.84 68 432196 32660 110124375
Acute coronary syndrome 16.95 9.84 41 432223 23071 110133964
Transaminases increased 16.95 9.84 162 432102 63228 110093807
Intestinal intraepithelial lymphocytes increased 16.89 9.84 11 432253 232 110156803
General symptom 16.88 9.84 74 432190 8772 110148263
Tendon disorder 16.88 9.84 71 432193 8266 110148769
Musculoskeletal disorder 16.79 9.84 40 432224 22624 110134411
Fistula discharge 16.74 9.84 26 432238 1620 110155415
Lymphadenopathy 16.70 9.84 164 432100 63671 110093364
Dizziness 16.66 9.84 2434 429830 695759 109461276
Product monitoring error 16.65 9.84 7 432257 8920 110148115
Food allergy 16.60 9.84 33 432231 19915 110137120
Eye haemorrhage 16.59 9.84 13 432251 11761 110145274
Disability 16.57 9.84 186 432078 30037 110126998
Squamous cell carcinoma of skin 16.54 9.84 26 432238 17177 110139858
Primary adrenal insufficiency 16.54 9.84 16 432248 608 110156427
Rash vesicular 16.53 9.84 106 432158 14546 110142489
Hepatocellular carcinoma 16.51 9.84 9 432255 9871 110147164
Rash maculo-papular 16.49 9.84 198 432066 74024 110083011
Hyperaesthesia 16.42 9.84 20 432244 14707 110142328
Bradykinesia 16.39 9.84 11 432253 10777 110146258
Lymphopenia 16.38 9.84 91 432173 40079 110116956
Hyperemesis gravidarum 16.34 9.84 15 432249 533 110156502
Femoral neck fracture 16.33 9.84 15 432249 12552 110144483
Brain natriuretic peptide increased 16.27 9.84 12 432252 11197 110145838
Left ventricular dysfunction 16.21 9.84 43 432221 23450 110133585
Peripheral arterial occlusive disease 16.18 9.84 8 432256 9272 110147763
Allergy test positive 16.17 9.84 19 432245 904 110156131
Sepsis 16.14 9.84 1082 431182 326264 109830771
Status epilepticus 16.10 9.84 66 432198 31505 110125530
Growth hormone deficiency 16.09 9.84 14 432250 463 110156572
Coronary artery stenosis 16.08 9.84 18 432246 13740 110143295
Coma scale abnormal 16.05 9.84 9 432255 9717 110147318
Oral candidiasis 16.03 9.84 255 432009 44505 110112530
Cytopenia 15.97 9.84 62 432202 30054 110126981
17-hydroxyprogesterone increased 15.97 9.84 4 432260 3 110157032
Bradypnoea 15.78 9.84 7 432257 8642 110148393
Feeling hot 15.72 9.84 467 431797 90639 110066396
Ventricular arrhythmia 15.71 9.84 10 432254 10077 110146958
Pulmonary congestion 15.63 9.84 65 432199 30901 110126134
Uterine cyst 15.61 9.84 12 432252 332 110156703
Cellulitis 15.59 9.84 374 431890 125642 110031393
Liver function test increased 15.59 9.84 455 431809 88093 110068942
Ischaemia 15.58 9.84 8 432256 9075 110147960
Thirst 15.54 9.84 39 432225 21668 110135367
Intracranial infection 15.49 9.84 12 432252 336 110156699
Pollakiuria 15.48 9.84 105 432159 44090 110112945
Glucocorticoid deficiency 15.42 9.84 21 432243 1161 110155874
Peritoneal tuberculosis 15.39 9.84 15 432249 575 110156460
Ataxia 15.32 9.84 63 432201 30045 110126990
Immunodeficiency 15.29 9.84 89 432175 38749 110118286
Asthma 15.28 9.84 1156 431108 249135 109907900
Chronic graft versus host disease 15.25 9.84 9 432255 9448 110147587
Haemoptysis 15.23 9.84 192 432072 71162 110085873
Myocarditis 15.23 9.84 63 432201 29992 110127043
Cortisol abnormal 15.22 9.84 8 432256 111 110156924
Thyrotoxic crisis 15.14 9.84 28 432236 2012 110155023
Dizziness postural 15.10 9.84 21 432243 14588 110142447
Hepatic encephalopathy 15.09 9.84 58 432206 28198 110128837
Cytomegalovirus infection 15.04 9.84 138 432126 54306 110102729
Adrenocorticotropic hormone deficiency 15.02 9.84 29 432235 2153 110154882
Geotrichum infection 15.01 9.84 21 432243 1191 110155844
Splenic peliosis 14.97 9.84 5 432259 19 110157016
Pericardial effusion 14.97 9.84 147 432117 57070 110099965
Breast cancer metastatic 14.94 9.84 13 432251 11168 110145867
Tooth disorder 14.86 9.84 62 432202 29447 110127588
Oxygen saturation decreased 14.79 9.84 484 431780 156498 110000537
Pain 14.76 9.84 4068 428196 950887 109206148
Platelet count increased 14.76 9.84 53 432211 26281 110130754
Temperature regulation disorder 14.75 9.84 17 432247 12809 110144226
Concussion 14.72 9.84 14 432250 11524 110145511
Performance status decreased 14.72 9.84 5 432259 7261 110149774
Lymphoproliferative disorder 14.56 9.84 5 432259 7213 110149822
Abdominal distension 14.51 9.84 830 431434 174273 109982762
Invasive ductal breast carcinoma 14.49 9.84 4 432260 6642 110150393
Bundle branch block right 14.45 9.84 16 432248 12275 110144760
Synovial cyst 14.43 9.84 14 432250 11416 110145619
Acute respiratory failure 14.43 9.84 207 432057 75053 110081982
Atrial tachycardia 14.43 9.84 9 432255 9169 110147866
Gastric haemorrhage 14.42 9.84 25 432239 15890 110141145
Polyomavirus-associated nephropathy 14.41 9.84 7 432257 8194 110148841
Mineralocorticoid deficiency 14.40 9.84 5 432259 22 110157013
Mastocytosis 14.37 9.84 17 432247 815 110156220
Portal hypertension 14.24 9.84 8 432256 8629 110148406
Blood pressure systolic decreased 14.21 9.84 19 432245 13422 110143613
Nephrotic syndrome 14.18 9.84 20 432244 13811 110143224
Visual acuity reduced 14.17 9.84 71 432193 32102 110124933
Mood altered 14.09 9.84 40 432224 21335 110135700
Sinus node dysfunction 14.05 9.84 9 432255 9038 110147997
Hyperpyrexia 14.00 9.84 7 432257 8062 110148973
Adrenal disorder 13.99 9.84 30 432234 2402 110154633
Disease recurrence 13.94 9.84 161 432103 60623 110096412
Antipsychotic drug level increased 13.91 9.84 5 432259 7010 110150025
Product substitution issue 13.88 9.84 45 432219 23016 110134019
Hepatitis B reactivation 13.75 9.84 6 432258 7478 110149557
Sudden death 13.73 9.84 49 432215 24346 110132689
Somnambulism 13.70 9.84 4 432260 6401 110150634
Clostridium difficile colitis 13.70 9.84 244 432020 43534 110113501
Carpal tunnel syndrome 13.69 9.84 44 432220 22566 110134469
Obstructive airways disorder 13.62 9.84 115 432149 46034 110111001
Depressed mood 13.59 9.84 162 432102 60647 110096388
Blood creatine increased 13.54 9.84 15 432249 11506 110145529
Osteoporosis 13.52 9.84 441 431823 86711 110070324
Aortic valve stenosis 13.52 9.84 4 432260 6346 110150689
Encephalopathy 13.49 9.84 229 432035 80826 110076209
Injection site warmth 13.47 9.84 30 432234 17375 110139660
Complication of device insertion 13.44 9.84 9 432255 8829 110148206
Diffuse large B-cell lymphoma recurrent 13.35 9.84 4 432260 6295 110150740
Orthopnoea 13.34 9.84 14 432250 11007 110146028
Microvillous inclusion disease 13.25 9.84 10 432254 269 110156766
Delirium 13.19 9.84 650 431614 134375 110022660
Aortic arteriosclerosis 13.13 9.84 14 432250 10924 110146111
Pneumatosis intestinalis 13.11 9.84 67 432197 8462 110148573
Sudden cardiac death 13.05 9.84 3 432261 5634 110151401
Face oedema 13.01 9.84 77 432187 33392 110123643
Hepatitis cholestatic 13.01 9.84 31 432233 17535 110139500
Deep vein thrombosis 13.01 9.84 432 431832 139455 110017580
Catheterisation cardiac 13.00 9.84 4 432260 6187 110150848
Tachycardia 12.94 9.84 739 431525 225906 109931129
Glycosylated haemoglobin increased 12.93 9.84 48 432216 23571 110133464
Therapy change 12.91 9.84 12 432252 9985 110147050
Lung adenocarcinoma 12.84 9.84 11 432253 9520 110147515
No adverse event 12.82 9.84 207 432057 73632 110083403
Syringe issue 12.82 9.84 11 432253 9514 110147521
Fear 12.78 9.84 47 432217 23146 110133889
N-terminal prohormone brain natriuretic peptide increased 12.77 9.84 4 432260 6117 110150918
Retinal haemorrhage 12.75 9.84 11 432253 9490 110147545
Pouchitis 12.75 9.84 21 432243 1376 110155659
Device occlusion 12.74 9.84 25 432239 15160 110141875
Euglycaemic diabetic ketoacidosis 12.73 9.84 16 432248 11607 110145428
Cortisol increased 12.72 9.84 14 432250 620 110156415
Blood pressure inadequately controlled 12.69 9.84 7 432257 7626 110149409
Blood pressure abnormal 12.65 9.84 45 432219 22379 110134656
Post-traumatic stress disorder 12.58 9.84 5 432259 6591 110150444
Spirometry abnormal 12.58 9.84 3 432261 5494 110151541
Squamous cell carcinoma 12.58 9.84 34 432230 18429 110138606
Injection site rash 12.55 9.84 48 432216 23371 110133664
Dysgeusia 12.55 9.84 195 432069 69790 110087245
Intervertebral disc degeneration 12.55 9.84 33 432231 18052 110138983
Drug use disorder 12.53 9.84 33 432231 18041 110138994
Coronary artery bypass 12.51 9.84 4 432260 6038 110150997
Herpes simplex oesophagitis 12.49 9.84 12 432252 452 110156583
Adrenal gland cancer metastatic 12.48 9.84 5 432259 35 110157000
Epidural lipomatosis 12.47 9.84 26 432238 2041 110154994
Gastric hypomotility 12.46 9.84 10 432254 295 110156740
Joint effusion 12.44 9.84 41 432223 20864 110136171
Disturbance in attention 12.43 9.84 169 432095 61826 110095209
Respiratory moniliasis 12.40 9.84 12 432252 456 110156579
Ischaemic cardiomyopathy 12.40 9.84 8 432256 8003 110149032
Brain oedema 12.38 9.84 71 432193 31027 110126008
Dust allergy 12.38 9.84 4 432260 5997 110151038
Cardiac operation 12.36 9.84 4 432260 5991 110151044
Pulmonary thrombosis 12.36 9.84 22 432242 13841 110143194
Cardiotoxicity 12.34 9.84 30 432234 16851 110140184
Anti-neutrophil cytoplasmic antibody positive vasculitis 12.31 9.84 3 432261 5414 110151621
Pneumothorax 12.27 9.84 84 432180 35201 110121834
Oliguria 12.23 9.84 35 432229 18622 110138413
Mycotic allergy 12.23 9.84 4 432260 5950 110151085
Colon cancer 12.19 9.84 29 432235 16414 110140621
Probiotic therapy 12.19 9.84 8 432256 171 110156864
Cryptitis 12.19 9.84 11 432253 382 110156653
Excessive skin 12.18 9.84 7 432257 117 110156918
Pharyngeal oedema 12.16 9.84 29 432235 16399 110140636
Pustular psoriasis 12.16 9.84 93 432171 13512 110143523
Haemorrhage intracranial 12.16 9.84 65 432199 28904 110128131
Neoplasm malignant 12.15 9.84 90 432174 37053 110119982
Ejection fraction decreased 12.01 9.84 102 432162 40778 110116257
Bradyphrenia 11.98 9.84 17 432247 11711 110145324
Cardiac tamponade 11.94 9.84 16 432248 11291 110145744
Priapism 11.93 9.84 4 432260 5857 110151178
Device related bacteraemia 11.92 9.84 19 432245 1211 110155824
Cytokine release syndrome 11.91 9.84 198 432066 70108 110086927
Tension headache 11.89 9.84 12 432252 9606 110147429
Diarrhoea haemorrhagic 11.87 9.84 103 432161 15536 110141499
Gastroenteritis norovirus 11.82 9.84 36 432228 3575 110153460
Vomiting 11.79 9.84 3275 428989 907400 109249635
International normalised ratio decreased 11.72 9.84 9 432255 8227 110148808
Lymphocytic hypophysitis 11.71 9.84 14 432250 679 110156356
Cardiac pacemaker insertion 11.66 9.84 5 432259 6296 110150739
Anticipatory anxiety 11.62 9.84 19 432245 1237 110155798
Psychiatric decompensation 11.62 9.84 4 432260 5761 110151274
Ascites 11.60 9.84 275 431989 92533 110064502
Mania 11.56 9.84 42 432222 20754 110136281
Atelectasis 11.52 9.84 90 432174 36622 110120413
Bronchopulmonary aspergillosis allergic 11.45 9.84 64 432200 8362 110148673
Cardiac dysfunction 11.41 9.84 5 432259 6218 110150817
Rotator cuff syndrome 11.39 9.84 31 432233 16763 110140272
Paraesthesia oral 11.38 9.84 190 432074 33481 110123554
Colitis 11.37 9.84 499 431765 101824 110055211
Abnormal loss of weight 11.36 9.84 14 432250 10243 110146792
Multiple allergies 11.35 9.84 19 432245 12244 110144791
Mental disorder 11.30 9.84 97 432167 38694 110118341
Diaphragm muscle weakness 11.24 9.84 8 432256 196 110156839
Hypersomnia 11.21 9.84 64 432200 27997 110129038
Antithrombin III 11.19 9.84 6 432258 87 110156948
Myocardial ischaemia 11.13 9.84 60 432204 26624 110130411
Weaning failure 11.13 9.84 15 432249 821 110156214
Epstein-Barr viraemia 11.09 9.84 35 432229 3544 110153491
Red blood cell sedimentation rate increased 11.08 9.84 392 431872 77910 110079125
Actinomycotic sepsis 11.04 9.84 8 432256 202 110156833
Progressive multifocal leukoencephalopathy 11.03 9.84 55 432209 24901 110132134
Limb injury 11.01 9.84 94 432170 37542 110119493
Tooth injury 11.01 9.84 26 432238 2220 110154815
B-lymphocyte count increased 10.99 9.84 7 432257 142 110156893
Accidental death 10.95 9.84 3 432261 5006 110152029
Aborted pregnancy 10.95 9.84 5 432259 50 110156985
Germ cell cancer 10.93 9.84 8 432256 205 110156830
Anosmia 10.93 9.84 20 432244 12452 110144583
Body temperature decreased 10.91 9.84 204 432060 36731 110120304
Pemphigoid 10.82 9.84 40 432224 19667 110137368
Anaplastic astrocytoma 10.82 9.84 7 432257 146 110156889
Diabetic neuropathy 10.82 9.84 7 432257 6992 110150043
Pruritus genital 10.81 9.84 6 432258 6516 110150519
Eosinophil count decreased 10.78 9.84 5 432259 6013 110151022
Small intestine gangrene 10.78 9.84 5 432259 52 110156983
Influenza like illness 10.77 9.84 263 432001 88149 110068886
Complications of transplanted kidney 10.76 9.84 8 432256 7434 110149601
Inhibitory drug interaction 10.75 9.84 3 432261 4944 110152091
Sinusitis fungal 10.73 9.84 29 432235 2691 110154344
Viral parotitis 10.72 9.84 3 432261 5 110157030
Kidney transplant rejection 10.71 9.84 19 432245 11968 110145067
Urine viscosity increased 10.69 9.84 5 432259 53 110156982
Cerebrospinal fluid leakage 10.67 9.84 25 432239 2123 110154912
Mass 10.67 9.84 40 432224 19590 110137445
Immune system disorder 10.67 9.84 23 432241 13478 110143557
Organising pneumonia 10.66 9.84 25 432239 14218 110142817
Clonus 10.63 9.84 11 432253 8705 110148330
Intermenstrual bleeding 10.63 9.84 7 432257 6927 110150108
Non-consummation 10.61 9.84 5 432259 54 110156981
Congestive cardiomyopathy 10.61 9.84 25 432239 14194 110142841
Pulmonary function test decreased 10.59 9.84 11 432253 8689 110148346
Sleep disorder due to general medical condition, hypersomnia type 10.59 9.84 24 432240 1995 110155040
Haemophagocytic lymphohistiocytosis 10.55 9.84 76 432188 31483 110125552
Hypertriglyceridaemia 10.55 9.84 103 432161 16051 110140984
Anorectal ulcer 10.53 9.84 5 432259 55 110156980
Craniocerebral injury 10.52 9.84 5 432259 5929 110151106
Device use error 10.50 9.84 12 432252 9077 110147958
Hyperuricaemia 10.48 9.84 26 432238 14505 110142530
Hyperphosphataemia 10.48 9.84 104 432160 16277 110140758
Pelvic fracture 10.47 9.84 25 432239 14129 110142906
Coronary arterial stent insertion 10.46 9.84 5 432259 5910 110151125
Haemarthrosis 10.44 9.84 8 432256 7321 110149714
Cerebral vasoconstriction 10.40 9.84 20 432244 1481 110155554
Stomatococcal infection 10.38 9.84 10 432254 378 110156657
Pituitary tumour 10.33 9.84 18 432246 1235 110155800
Spinal compression fracture 10.32 9.84 37 432227 18355 110138680
Rhinitis 10.29 9.84 134 432130 22411 110134624
Vaccination site inflammation 10.23 9.84 5 432259 59 110156976
Hypogammaglobulinaemia 10.22 9.84 42 432222 20034 110137001
Fracture 10.19 9.84 56 432208 24732 110132303
Movement disorder 10.18 9.84 92 432172 36312 110120723
Anger 10.16 9.84 39 432225 18968 110138067
Spinal operation 10.16 9.84 17 432247 10955 110146080
Intestinal ischaemia 10.14 9.84 31 432233 16148 110140887
Multiple fractures 10.12 9.84 12 432252 8928 110148107
Vulval haemorrhage 10.11 9.84 4 432260 27 110157008
Lung transplant 10.09 9.84 4 432260 5282 110151753
Granulicatella infection 10.07 9.84 7 432257 165 110156870
Optic nerve operation 10.07 9.84 11 432253 483 110156552
Peritonitis bacterial 10.05 9.84 16 432248 10517 110146518
Skin fragility 10.02 9.84 17 432247 1141 110155894
Catatonia 10.01 9.84 18 432246 11282 110145753
Vitamin B12 decreased 10.00 9.84 4 432260 5253 110151782
Cerebral microangiopathy 10.00 9.84 10 432254 396 110156639
Infant irritability 9.99 9.84 4 432260 28 110157007
Renal tubular acidosis 9.98 9.84 3 432261 4712 110152323
Duodenal ulcer haemorrhage 9.97 9.84 10 432254 8027 110149008
Dental caries 9.90 9.84 22 432242 12751 110144284
Sebaceous carcinoma 9.86 9.84 7 432257 171 110156864

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Aspergillus infection 65.08 43.14 18 238 65 113632
Drug-induced liver injury 57.74 43.14 16 240 58 113639

Pharmacologic Action:

SourceCodeDescription
ATC A01AC03 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC A07EA02 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC C05AA01 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AA02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, weak (group I)
ATC D07BA04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, weak, combinations with antiseptics
ATC D07CA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, weak, combinations with antibiotics
ATC D07XA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, weak, other combinations
ATC H02AB09 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD60 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BA02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01BB01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids and mydriatics in combination
ATC S01CA03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S01CB03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA01 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S02CA03 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03CA04 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35472 anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:49167 anti-asthmatic drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:50864 insulin-sensitizing drug
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64952 anti-HSV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77715 nasal decongestant
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:176497 geroprotector
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

A01AC Corticosteroids for local oral treatment 3 drugs
dexamethasoneprednisolonetriamcinolone
A07EA Corticosteroids acting locally 6 drugs
beclometasone dipropionatebetamethasonebudesonideprednisoloneprednisonetixocortol
C05AA Corticosteroids 8 drugs
betamethasonedexamethasonefluocinolone acetonidefluocinonidefluocortolonefluorometholoneprednisolonetriamcinolone
D07AA Corticosteroids, weak (group I) 2 drugs
methylprednisoloneprednisolone
D07BA Corticosteroids, weak, combinations with antiseptics 1 drug
prednisolone
D07CA Corticosteroids, weak, combinations with antibiotics 2 drugs
methylprednisoloneprednisolone
D07XA Corticosteroids, weak, other combinations 1 drug
prednisolone
H02AB Glucocorticoids 15 drugs
betamethasonecloprednolcortivazoldeflazacortdexamethasonefluocortolonemeprednisonemethylprednisoloneparamethasone acetateprednisoloneprednisoneprednylidene show all 15 →
R01AD Corticosteroids 12 drugs
beclometasone dipropionatebetamethasonebudesonideciclesonidedexamethasoneflunisolidefluticasone furoatefluticasone propionatemometasone furoateprednisolonetixocortoltriamcinolone
S01BA Corticosteroids, plain 15 drugs
alclometasone dipropionatebetamethasoneclobetasol propionateclobetasone butyratedesonidedexamethasonedifluprednatefluocinolone acetonidefluorometholoneformocortalloteprednol etabonatemedrysone show all 15 →
S01BB Corticosteroids and mydriatics in combination 3 drugs
betamethasonefluorometholoneprednisolone
S01CA Corticosteroids and antiinfectives in combination 11 drugs
betamethasonechloroprednisoneclobetasone butyratedexamethasonefludrocortisone acetatefluocinolone acetonidefluocortolonefluorometholoneloteprednol etabonatemethylprednisoloneprednisolone
S01CB Corticosteroids/antiinfectives/mydriatics in combination 4 drugs
betamethasonedexamethasonefluorometholoneprednisolone
S02BA Corticosteroids 4 drugs
betamethasonedexamethasonefluocinolone acetonideprednisolone
S02CA Corticosteroids and antiinfectives in combination 6 drugs
dexamethasonefludrocortisone acetateflumetasonefluocinolone acetonideprednisolonetriamcinolone
S03CA Corticosteroids and antiinfectives in combination 5 drugs
betamethasonedexamethasonefludrocortisone acetatemethylprednisoloneprednisolone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Proctitis indication 3951002 DOID:3127
Keratitis indication 5888003 DOID:4677
Tinea pedis indication 6020002 DOID:12403
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Chronic ulcerative proctitis indication 52231000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Ulcerative colitis indication 64766004 DOID:8577
Löffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Hemorrhoids indication 70153002 DOID:9746
Transfusion reaction due to serum protein reaction indication 72284000
Acquired thrombocytopenia indication 74576004 DOID:11126
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Tinea corporis indication 84849002
Autoimmune disease indication 85828009
Corneal abrasion indication 85848002
Infective otitis externa indication 86981007 DOID:9463
Infection by larvae of Trichinella spiralis indication 88264003
Acne vulgaris indication 88616000
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Tinea cruris indication 399029005
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Recurrent herpes simplex labialis indication 402892009
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Aphthous ulcer of mouth indication 426965005 DOID:9663
Allergic conjunctivitis indication 473460002 DOID:11204
Post traumatic osteoarthritis indication 699262001
Itching of ear indication 699392007
Inflammatory dermatosis indication 703938007
Post-Op Ocular Inflammation indication
Mastoidectomy Cavity Infections indication
Superficial Ocular Infection indication
Gingival Disorders indication
Minor Bacterial Skin Infections indication
Synovitis due to Osteoarthritis indication
Diagnostic Test for Cushing's Syndrome indication
Transfusion Reaction Urticaria indication
Staphylococcus Aureus Otitis Externa indication
Systemic Dermatomyositis indication
Erythroblastic Anemia indication
Chronic purulent otitis media off-label use 38394007 DOID:14247
Respiratory distress syndrome in the newborn off-label use 46775006
Adrenoleukodystrophy off-label use 65389002 DOID:10588
Pityriasis simplex off-label use 200767005
Allergic otitis externa off-label use 405821001
Itching of skin off-label use 418363000
Otitis Externa Seborrhea off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Congenital Pituitary Hypoplasia off-label use
Otitis Externa Eczema off-label use
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Bacterial septicemia contraindication 10001005 DOID:0040085
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Measles contraindication 14189004 DOID:8622
Esophagitis contraindication 16761005 DOID:11963
Mood swings contraindication 18963009
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Cirrhosis of liver contraindication 19943007 DOID:5082
Herpes zoster auricularis contraindication 21954000 DOID:9210
Glaucoma contraindication 23986001 DOID:1686
Abscess of intestine contraindication 24557004
Acute tuberculosis contraindication 25629007
Shock contraindication 27942005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Bullous myringitis contraindication 33528003 DOID:13791
Severe myopia contraindication 34187009
Hyperthyroidism contraindication 34486009 DOID:7998
Gastrointestinal fistula contraindication 37831005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Duodenal ulcer disease contraindication 51868009 DOID:1724
Perforation of tympanic membrane contraindication 60442001
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Third degree burn injury contraindication 80247002
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Disorder of mucous membrane contraindication 95351003
Bilateral cataracts contraindication 95722004
Open wound contraindication 125643001
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Tuberculosis of ear contraindication 186269001
Ophthalmic herpes simplex contraindication 186542001
Heart block contraindication 233916004
Anastomosis of intestine contraindication 235407009
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Telangiectasia disorder contraindication 247479008
Diverticulitis of gastrointestinal tract contraindication 271366000
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Infective otitis media contraindication 312218008
Skin irritation contraindication 367466007
Vaccinia keratitis contraindication 397552005
Gastric ulcer contraindication 397825006 DOID:10808
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Blister contraindication 417237009
Denuded skin contraindication 418242004
Exposure to varicella contraindication 444453009




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Acute otitis externa Indication
Cats Chronic otitis externa Indication
Cats Ear canker Indication
Cats Inflammatory conditions of the external ear canal Indication
Cats Allergy Indication
Cats Infectious skin conditions Indication
Cats Traumatic skin conditions Indication
Cats Prevention of bacterial infections in superficial wounds Indication
Cats Prevention of bacterial infections in cuts Indication
Cats Prevention of bacterial infections in abrasions Indication
Cats Allergic dermatoses Indication
Cats Infections associated with minor burns and wounds Indication
Cats Nonspecific pruritus Indication
Dogs Acute otitis externa Indication
Dogs Chronic otitis externa Indication
Dogs Ear canker Indication
Dogs Inflammatory conditions of the external ear canal Indication
Dogs Allergy Indication
Dogs Infectious skin conditions Indication
Dogs Traumatic skin conditions Indication
Dogs Prevention of bacterial infections in superficial wounds Indication
Dogs Prevention of bacterial infections in cuts Indication
Dogs Prevention of bacterial infections in abrasions Indication
Dogs Allergic dermatoses Indication
Dogs Infections associated with minor burns and wounds Indication
Dogs Nonspecific pruritus Indication
Horses No Use Class Stated Or Implied Indication

🐶 Veterinary products

ProductApplicantIngredients
Liqua-Cortril Spray, Terra-Cortril Spray Zoetis Inc. 2
Cortisporin Veterinary Ophthalmic Ointment Intervet Inc. 4

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.31 acidic
pKa2 13.65 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.5MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9717740 Nov. 19, 2032 TREATMENT OF ADRENAL INSUFFICIENCY
1MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9717740 Nov. 19, 2032 TREATMENT OF ADRENAL INSUFFICIENCY
2MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9717740 Nov. 19, 2032 TREATMENT OF ADRENAL INSUFFICIENCY
5MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9717740 Nov. 19, 2032 TREATMENT OF ADRENAL INSUFFICIENCY
0.5MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9675559 Jan. 10, 2033 TREATMENT OF ADRENAL INSUFFICIENCY
1MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9675559 Jan. 10, 2033 TREATMENT OF ADRENAL INSUFFICIENCY
2MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9675559 Jan. 10, 2033 TREATMENT OF ADRENAL INSUFFICIENCY
5MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9675559 Jan. 10, 2033 TREATMENT OF ADRENAL INSUFFICIENCY
0.5MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9649280 May 12, 2034 TREATMENT OF ADRENAL INSUFFICIENCY
1MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9649280 May 12, 2034 TREATMENT OF ADRENAL INSUFFICIENCY
2MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9649280 May 12, 2034 TREATMENT OF ADRENAL INSUFFICIENCY
5MG ALKINDI SPRINKLE ETON N213876 Sept. 29, 2020 RX GRANULE ORAL 9649280 May 12, 2034 TREATMENT OF ADRENAL INSUFFICIENCY
1MG/ML KHINDIVI ETON N218980 May 28, 2025 RX SOLUTION ORAL 11904046 Feb. 23, 2043 TREATMENT OF ADRENAL INSUFFICIENCY WITH AN ORAL LIQUID FORMULATION OF HYDROCORTISONE
1MG/ML KHINDIVI ETON N218980 May 28, 2025 RX SOLUTION ORAL 12133914 Feb. 23, 2043 TREATMENT OF PRIMARY OR SECONDARY ADRENOCORTICAL INSUFFICIENCY WITH AN ORAL LIQUID FORMULATION OF HYDROCORTISONE

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 0.2% BASE;1% CIPROFLOXACIN HYDROCHLORIDE AND HYDROCORTISONE COSETTE PHARMS NC A218273 Nov. 10, 2025 RX SUSPENSION/DROPS OTIC June 2, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.50 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Mineralocorticoid receptor Nuclear hormone receptor AGONIST IC50 9.95 IUPHAR
Nitric oxide synthase, inducible Enzyme IC50 8 WOMBAT-PK
Corticosteroid-binding globulin Secreted Ki 7.88 WOMBAT-PK
Sex hormone-binding globulin Secreted Kd 6.20 CHEMBL
Probable G-protein coupled receptor 33 GPCR Kd 7.92 IUPHAR
Glucocorticoid receptor Transcription factor IC50 7.60 CHEMBL
Glucocorticoid receptor Transcription factor Kd 7.37 CHEMBL

External reference:

IDSource
4017941 VUID
N0000146291 NUI
D00088 KEGG_DRUG
4017941 VANDF
C0020268 UMLSCUI
CHEBI:17650 CHEBI
HCY PDB_CHEM_ID
CHEMBL389621 ChEMBL_ID
DB00741 DRUGBANK_ID
D006854 MESH_DESCRIPTOR_UI
5754 PUBCHEM_CID
38 INN_ID
WI4X0X7BPJ UNII
202643 RXNORM
174 MMSL
2500 MMSL
4837 MMSL
d00254 MMSL
002147 NDDF
16602005 SNOMEDCT_US
396458002 SNOMEDCT_US
56423005 SNOMEDCT_US
2868 IUPHAR_LIGAND_ID
WI4X0X7BPJ INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CORTEF HUMAN PRESCRIPTION DRUG LABEL 1 0009-0012 TABLET 5 mg ORAL NDA 14 sections
CORTEF HUMAN PRESCRIPTION DRUG LABEL 1 0009-0031 TABLET 10 mg ORAL NDA 14 sections
CORTEF HUMAN PRESCRIPTION DRUG LABEL 1 0009-0044 TABLET 20 mg ORAL NDA 14 sections
Aquanil HC HUMAN OTC DRUG LABEL 1 0096-0732 LOTION 0.01 g TOPICAL OTC Monograph Drug 10 sections
Aquanil HC HUMAN OTC DRUG LABEL 1 0096-0732 LOTION 0.01 g TOPICAL OTC Monograph Drug 10 sections
Aquanil HC HUMAN OTC DRUG LABEL 1 0096-0810 LOTION 0.01 g TOPICAL OTC Monograph Drug 10 sections
Good Sense Anti Itch HUMAN OTC DRUG LABEL 1 0113-0471 OINTMENT 1 g TOPICAL OTC Monograph Drug 13 sections
good sense anti itch HUMAN OTC DRUG LABEL 1 0113-0541 CREAM 1 g TOPICAL OTC Monograph Drug 13 sections
HYDROCORTISONE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1696 TABLET 5 mg ORAL ANDA 14 sections
HYDROCORTISONE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1697 TABLET 10 mg ORAL ANDA 14 sections
HYDROCORTISONE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1700 TABLET 20 mg ORAL ANDA 14 sections
hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0168-0015 CREAM 10 mg TOPICAL ANDA 19 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0168-0020 OINTMENT 10 mg TOPICAL ANDA 18 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0168-0080 CREAM 25 mg TOPICAL ANDA 17 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0168-0146 OINTMENT 25 mg TOPICAL ANDA 17 sections
Texacort HUMAN PRESCRIPTION DRUG LABEL 1 0178-0455 SOLUTION 25 mg TOPICAL ANDA 20 sections
Xerese HUMAN PRESCRIPTION DRUG LABEL 2 0187-5104 CREAM 10 mg TOPICAL NDA 26 sections
Alacort HUMAN PRESCRIPTION DRUG LABEL 1 0316-0126 CREAM 10 mg TOPICAL ANDA 19 sections
Alacort HUMAN PRESCRIPTION DRUG LABEL 1 0316-0126 CREAM 10 mg TOPICAL ANDA 19 sections
Alacort HUMAN PRESCRIPTION DRUG LABEL 1 0316-0128 CREAM 25 mg TOPICAL ANDA 19 sections
Alacort HUMAN PRESCRIPTION DRUG LABEL 1 0316-0128 CREAM 25 mg TOPICAL ANDA 19 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0316-0186 CREAM 10 mg TOPICAL ANDA 19 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0316-0186 CREAM 10 mg TOPICAL ANDA 19 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0316-0193 CREAM 25 mg TOPICAL ANDA 19 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0316-0193 CREAM 25 mg TOPICAL ANDA 19 sections
Hydrocortisone Plus HUMAN OTC DRUG LABEL 1 0363-0063 CREAM 10 mg TOPICAL OTC MONOGRAPH NOT FINAL 15 sections
Maximum Strength Hydrocortisone HUMAN OTC DRUG LABEL 1 0363-0230 OINTMENT 1 g TOPICAL OTC Monograph Drug 12 sections
Hydrocortisone Cream Intensive Healing HUMAN OTC DRUG LABEL 1 0363-0237 CREAM 1 g TOPICAL OTC Monograph Drug 13 sections
Hydrocortisone Maximum Strength HUMAN OTC DRUG LABEL 1 0363-0339 CREAM 1 g TOPICAL OTC MONOGRAPH NOT FINAL 13 sections
No Mess Hydrocortisone Applicator HUMAN OTC DRUG LABEL 1 0363-0358 LIQUID 10 mg TOPICAL OTC Monograph Drug 13 sections