hydrocortisone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 1388 50-23-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone
  • 17-hydroxycorticosterone
  • acticort
  • cetacort
  • hydracort
  • hydrasson
  • hydrocortisyl
  • cortisol
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
  • Molecular weight: 362.47
  • Formula: C21H30O5
  • CLOGP: 1.89
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.26
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.42 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 353.81 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.38 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.20 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 5, 1952 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 301.93 9.40 9 109793 145911 46430349
Drug hypersensitivity 298.79 9.40 1249 108553 242576 46333684
Adrenocortical insufficiency acute 276.04 9.40 107 109695 1199 46575061
Infusion related reaction 263.29 9.40 671 109131 100537 46475723
Adrenal insufficiency 247.04 9.40 222 109580 12902 46563358
Steroid withdrawal syndrome 174.25 9.40 59 109743 432 46575828
Toxicity to various agents 149.07 9.40 167 109635 211599 46364661
Febrile bone marrow aplasia 113.47 9.40 108 109694 6754 46569506
Death 112.02 9.40 409 109393 335139 46241121
Drug abuse 106.98 9.40 12 109790 63396 46512864
Colitis ulcerative 105.08 9.40 166 109636 17566 46558694
Craniopharyngioma 98.28 9.40 29 109773 126 46576134
Hypofibrinogenaemia 90.19 9.40 46 109756 1024 46575236
Intentional overdose 84.40 9.40 24 109778 64920 46511340
Overdose 77.78 9.40 75 109727 101904 46474356
Blood pressure fluctuation 74.04 9.40 197 109605 30251 46546009
Anti-cyclic citrullinated peptide antibody positive 63.88 9.40 140 109662 19005 46557255
Pituitary tumour benign 63.58 9.40 43 109759 1638 46574622
Pericarditis 62.47 9.40 159 109643 23768 46552492
Intentional product use issue 59.43 9.40 264 109538 52516 46523744
Hypersensitivity 55.05 9.40 568 109234 149753 46426507
Secondary adrenocortical insufficiency 52.45 9.40 30 109772 845 46575415
Adrenal suppression 50.13 9.40 30 109772 921 46575339
Drug interaction 48.83 9.40 279 109523 202815 46373445
Discomfort 48.50 9.40 228 109574 46442 46529818
Fall 45.50 9.40 525 109277 328572 46247688
Device expulsion 44.52 9.40 6 109796 27536 46548724
Tendonitis 43.82 9.40 101 109701 14176 46562084
Product use issue 43.29 9.40 375 109427 94269 46481991
Cardiac failure congestive 42.92 9.40 95 109707 91655 46484605
Colitis 42.18 9.40 187 109615 37160 46539100
Duodenal ulcer perforation 41.54 9.40 73 109729 8429 46567831
Frequent bowel movements 40.59 9.40 91 109711 12541 46563719
Cortisol decreased 40.19 9.40 27 109775 1017 46575243
Musculoskeletal injury 40.06 9.40 14 109788 114 46576146
Hyperadrenocorticism 40.00 9.40 18 109784 300 46575960
Suicide attempt 39.09 9.40 43 109759 54993 46521267
Heart rate irregular 38.04 9.40 113 109689 18478 46557782
Wound 38.01 9.40 200 109602 42602 46533658
Hypothalamo-pituitary disorder 37.27 9.40 22 109780 658 46575602
Insulin-like growth factor increased 37.19 9.40 23 109779 750 46575510
Neoplasm recurrence 36.69 9.40 36 109766 2337 46573923
Product dose omission issue 36.57 9.40 239 109563 168281 46407979
Hypothalamic pituitary adrenal axis suppression 36.51 9.40 14 109788 152 46576108
Perioral dermatitis 36.28 9.40 12 109790 81 46576179
Urticaria 36.06 9.40 430 109372 117462 46458798
Cardio-respiratory arrest 36.06 9.40 53 109749 59816 46516444
Septic shock 35.72 9.40 246 109556 57647 46518613
Human bocavirus infection 35.53 9.40 17 109785 328 46575932
Hypopituitarism 35.42 9.40 22 109780 723 46575537
Hand deformity 35.26 9.40 168 109634 34406 46541854
Rheumatoid factor positive 35.09 9.40 117 109685 20344 46555916
Rash 34.19 9.40 1088 108714 355424 46220836
Febrile neutropenia 33.87 9.40 356 109446 94271 46481989
Hypophysitis 33.23 9.40 27 109775 1366 46574894
Urticaria thermal 32.09 9.40 11 109791 84 46576176
Respiratory arrest 30.58 9.40 21 109781 33795 46542465
Cerebrovascular accident 29.88 9.40 129 109673 100910 46475350
Tendon rupture 29.67 9.40 60 109742 7699 46568561
Tendon pain 29.55 9.40 35 109767 2815 46573445
Asphyxia 29.01 9.40 48 109754 5278 46570982
Body temperature fluctuation 28.74 9.40 28 109774 1802 46574458
Clostridium difficile colitis 28.26 9.40 102 109700 18451 46557809
Intentional self-injury 27.78 9.40 11 109791 24155 46552105
Allergy test positive 27.11 9.40 14 109788 320 46575940
Gastroenteritis norovirus 26.47 9.40 25 109777 1548 46574712
Female genital tract fistula 25.99 9.40 35 109767 3204 46573056
Secondary immunodeficiency 25.39 9.40 20 109782 967 46575293
Synovitis 25.36 9.40 237 109565 60838 46515422
Antithrombin III 25.20 9.40 11 109791 170 46576090
Insulin-like growth factor decreased 24.91 9.40 14 109788 381 46575879
Glossodynia 24.73 9.40 184 109618 44189 46532071
Poor venous access 24.65 9.40 58 109744 8250 46568010
Helicobacter infection 23.69 9.40 71 109731 11665 46564595
Cardiac failure 23.68 9.40 102 109700 79846 46496414
Interstitial lung disease 23.50 9.40 58 109744 53891 46522369
Anal abscess 23.35 9.40 35 109767 3537 46572723
Serotonin syndrome 23.33 9.40 14 109788 24206 46552054
Condition aggravated 23.22 9.40 747 109055 244305 46331955
Airway peak pressure increased 22.86 9.40 12 109790 284 46575976
Erythrodermic psoriasis 22.84 9.40 18 109784 871 46575389
Abdominal pain 22.79 9.40 705 109097 229326 46346934
Acute kidney injury 22.42 9.40 405 109397 235450 46340810
Drug withdrawal syndrome 22.22 9.40 19 109783 27365 46548895
Meningitis candida 21.72 9.40 7 109795 43 46576217
Diaphragm muscle weakness 21.35 9.40 6 109796 21 46576239
Diarrhoea haemorrhagic 20.75 9.40 51 109751 7458 46568802
Urinary tract infection 20.74 9.40 671 109131 219595 46356665
Chronic obstructive pulmonary disease 20.66 9.40 68 109734 57565 46518695
Breast cancer 20.57 9.40 48 109754 45470 46530790
Adrenal disorder 20.19 9.40 19 109783 1171 46575089
Cerebral microangiopathy 20.18 9.40 10 109792 209 46576051
Rhinovirus infection 20.12 9.40 33 109769 3603 46572657
Arthralgia 20.11 9.40 1049 108753 363554 46212706
Enterococcal sepsis 20.11 9.40 20 109782 1320 46574940
Eczema 19.98 9.40 98 109704 20302 46555958
Perfume sensitivity 19.88 9.40 14 109788 570 46575690
Neutropenic sepsis 19.84 9.40 69 109733 12255 46564005
Haematochezia 19.51 9.40 153 109649 37340 46538920
Lactic acidosis 19.47 9.40 31 109771 33878 46542382
Anaemia 19.33 9.40 456 109346 255323 46320937
Myocardial infarction 19.32 9.40 142 109660 97386 46478874
Pituitary tumour recurrent 19.22 9.40 7 109795 65 46576195
Neutropenic infection 18.98 9.40 18 109784 1120 46575140
Pemphigus 18.95 9.40 176 109626 45098 46531162
Erythema 18.75 9.40 454 109348 142366 46433894
Fistula 18.64 9.40 51 109751 7959 46568301
Inappropriate schedule of product administration 18.50 9.40 234 109568 64779 46511481
Faecal calprotectin increased 18.43 9.40 22 109780 1784 46574476
Tendon disorder 18.36 9.40 38 109764 4957 46571303
Coma 18.17 9.40 73 109729 58276 46517984
Drug level below therapeutic 18.08 9.40 29 109773 3108 46573152
Arteriosclerosis coronary artery 18.06 9.40 51 109751 8105 46568155
Tuberculosis gastrointestinal 18.00 9.40 11 109791 351 46575909
Hypercapnia 17.96 9.40 36 109766 4590 46571670
Suicidal ideation 17.90 9.40 70 109732 56312 46519948
Natural killer cell count decreased 17.83 9.40 6 109796 43 46576217
Wrong technique in product usage process 17.64 9.40 67 109735 54355 46521905
Product quality issue 17.42 9.40 36 109766 35612 46540648
Bacterial infection 17.41 9.40 80 109722 16136 46560124
Salpingo-oophorectomy unilateral 17.40 9.40 11 109791 373 46575887
Injection site swelling 17.06 9.40 44 109758 40283 46535977
Proctalgia 17.06 9.40 36 109766 4760 46571500
Eczema herpeticum 16.99 9.40 7 109795 93 46576167
Plasma cell myeloma 16.98 9.40 51 109751 44427 46531833
Syncope 16.95 9.40 161 109641 104642 46471618
Renal impairment 16.87 9.40 104 109698 74268 46501992
Hypogonadism 16.79 9.40 7 109795 96 46576164
Intentional product misuse 16.62 9.40 56 109746 47072 46529188
Cerebral vasoconstriction 16.59 9.40 16 109786 1017 46575243
Glomerulonephritis chronic 16.33 9.40 8 109794 163 46576097
Arthropathy 16.31 9.40 285 109517 84415 46491845
PO2 decreased 16.30 9.40 19 109783 1503 46574757
Blood creatine phosphokinase increased 16.25 9.40 25 109777 27699 46548561
Astrocytoma 16.16 9.40 7 109795 106 46576154
Sedation 16.15 9.40 18 109784 22892 46553368
Electrocardiogram QT prolonged 16.12 9.40 64 109738 51261 46524999
Injection site reaction 16.11 9.40 58 109744 47791 46528469
Mastocytosis 16.04 9.40 11 109791 429 46575831
Anal fistula 16.03 9.40 25 109777 2616 46573644
Prescription drug used without a prescription 15.85 9.40 18 109784 1384 46574876
Thyroid stimulating immunoglobulin increased 15.82 9.40 7 109795 112 46576148
Bronchopulmonary aspergillosis 15.75 9.40 46 109756 7450 46568810
Malignant neoplasm progression 15.67 9.40 89 109713 64837 46511423
Normal tension glaucoma 15.50 9.40 6 109796 67 46576193
Pyoderma gangrenosum 15.50 9.40 25 109777 2692 46573568
Leukoencephalopathy 15.35 9.40 31 109771 3973 46572287
Nausea 15.31 9.40 1401 108401 686053 45890207
Off label use 15.31 9.40 1063 108739 378778 46197482
Diabetes insipidus 15.22 9.40 22 109780 2152 46574108
Excessive eye blinking 15.19 9.40 12 109790 583 46575677
Aspergillus infection 15.17 9.40 43 109759 6847 46569413
CSF lymphocyte count abnormal 15.17 9.40 3 109799 0 46576260
Gastrointestinal haemorrhage 15.15 9.40 113 109689 77260 46499000
Injury 14.98 9.40 164 109638 43863 46532397
Acute myocardial infarction 14.96 9.40 33 109769 31891 46544369
Lung hyperinflation 14.93 9.40 16 109786 1153 46575107
Pneumatosis intestinalis 14.92 9.40 21 109781 2004 46574256
B-lymphocyte count increased 14.92 9.40 7 109795 129 46576131
Skin injury 14.88 9.40 18 109784 1480 46574780
Atrial fibrillation 14.75 9.40 164 109638 103426 46472834
Pseudostroke 14.70 9.40 4 109798 12 46576248
Crohn's disease 14.66 9.40 42 109760 6729 46569531
Neuroleptic malignant syndrome 14.65 9.40 4 109798 11118 46565142
Staphylococcal infection 14.44 9.40 138 109664 35633 46540627
Injection site erythema 14.43 9.40 109 109693 74318 46501942
Natural killer-cell leukaemia 14.38 9.40 5 109797 40 46576220
Metastases to bone 14.33 9.40 12 109790 17464 46558796
Blood growth hormone increased 14.31 9.40 10 109792 402 46575858
Rheumatoid arthritis 14.30 9.40 443 109359 239772 46336488
Blood creatinine increased 14.30 9.40 113 109689 76290 46499970
Swelling face 14.27 9.40 189 109613 52870 46523390
Faecal volume decreased 14.22 9.40 7 109795 144 46576116
Mucous stools 14.22 9.40 23 109779 2482 46573778
Pituitary haemorrhage 14.22 9.40 6 109796 85 46576175
Swelling 14.06 9.40 388 109414 124123 46452137
PCO2 increased 14.01 9.40 16 109786 1238 46575022
Pneumatosis 13.93 9.40 10 109792 420 46575840
Kidney infection 13.92 9.40 77 109725 16712 46559548
Systemic lupus erythematosus 13.90 9.40 223 109579 64957 46511303
Aborted pregnancy 13.87 9.40 5 109797 45 46576215
Skin atrophy 13.84 9.40 31 109771 4269 46571991
Blood count abnormal 13.79 9.40 13 109789 17865 46558395
Enteritis 13.76 9.40 41 109761 6714 46569546
Pulmonary arterial hypertension 13.70 9.40 25 109777 25903 46550357
Skin weeping 13.68 9.40 8 109794 235 46576025
Encephalitis autoimmune 13.68 9.40 15 109787 1109 46575151
Anal fissure 13.61 9.40 23 109779 2573 46573687
Suffocation feeling 13.56 9.40 16 109786 1282 46574978
Blood triglycerides decreased 13.49 9.40 5 109797 49 46576211
Pseudomonas infection 13.49 9.40 52 109750 9706 46566554
Chest discomfort 13.40 9.40 292 109510 89977 46486283
Secondary hypogonadism 13.39 9.40 6 109796 99 46576161
Shared psychotic disorder 13.27 9.40 4 109798 19 46576241
Drug level above therapeutic 13.26 9.40 27 109775 3482 46572778
Disease progression 13.22 9.40 144 109658 91156 46485104
Skin fragility 13.18 9.40 11 109791 578 46575682
Ear canal erythema 13.09 9.40 3 109799 3 46576257
Geotrichum infection 13.09 9.40 10 109792 462 46575798
Enterobacter infection 13.07 9.40 19 109783 1868 46574392
Haemoglobin decreased 13.01 9.40 219 109583 128730 46447530
Thyrotoxic crisis 12.84 9.40 12 109790 733 46575527
Hepatic function abnormal 12.76 9.40 40 109762 34381 46541879
Hospitalisation 12.69 9.40 92 109710 63293 46512967
Thyroxine free increased 12.61 9.40 12 109790 750 46575510
Cardiac arrest 12.52 9.40 144 109658 90255 46486005
Platelet count decreased 12.47 9.40 163 109639 99861 46476399
Vulvovaginal pain 12.44 9.40 20 109782 2147 46574113
Feeding intolerance 12.41 9.40 10 109792 500 46575760
Status asthmaticus 12.29 9.40 13 109789 923 46575337
Increased bronchial secretion 12.28 9.40 17 109785 1597 46574663
Respiratory acidosis 12.23 9.40 37 109765 6111 46570149
Emotional distress 12.16 9.40 118 109684 30589 46545671
Abortion spontaneous 12.13 9.40 57 109745 43589 46532671
Herpes simplex 12.11 9.40 41 109761 7182 46569078
Herpes simplex hepatitis 12.08 9.40 8 109794 294 46575966
Non-consummation 12.03 9.40 5 109797 68 46576192
Anorectal ulcer 12.03 9.40 5 109797 68 46576192
Intestinal resection 12.02 9.40 20 109782 2210 46574050
Oropharyngeal pain 12.01 9.40 243 109559 73925 46502335
Excessive cerumen production 11.75 9.40 7 109795 213 46576047
Abnormal faeces 11.72 9.40 28 109774 4021 46572239
Colonic abscess 11.72 9.40 12 109790 820 46575440
Femur fracture 11.70 9.40 46 109756 36951 46539309
Bronchospasm 11.69 9.40 70 109732 15637 46560623
Coronary artery dissection 11.67 9.40 11 109791 679 46575581
Visual pathway disorder 11.62 9.40 4 109798 31 46576229
Hypertensive crisis 11.60 9.40 9 109793 13606 46562654
Ileectomy 11.59 9.40 6 109796 138 46576122
Cognitive disorder 11.57 9.40 46 109756 36837 46539423
Autoimmune nephritis 11.53 9.40 8 109794 318 46575942
Uterine cyst 11.48 9.40 9 109793 432 46575828
Anti-thyroid antibody positive 11.41 9.40 9 109793 436 46575824
Blood corticotrophin increased 11.40 9.40 4 109798 33 46576227
Cerebrospinal fluid leakage 11.35 9.40 12 109790 851 46575409
Anal ulcer 11.32 9.40 9 109793 441 46575819
Transient ischaemic attack 11.29 9.40 43 109759 34860 46541400
Melaena 11.22 9.40 31 109771 27741 46548519
Brachycephaly 11.19 9.40 4 109798 35 46576225
Sinusitis fungal 11.18 9.40 12 109790 866 46575394
Candida infection 11.16 9.40 90 109712 22150 46554110
Bradycardia 11.08 9.40 101 109701 66197 46510063
Hypoperfusion 11.06 9.40 15 109787 1382 46574878
Complication associated with device 11.03 9.40 12 109790 15429 46560831
Skin wrinkling 11.03 9.40 12 109790 880 46575380
Therapeutic response shortened 11.02 9.40 32 109770 5167 46571093
Hyperaemia 10.91 9.40 18 109784 1974 46574286
Therapeutic reaction time decreased 10.88 9.40 13 109789 1055 46575205
Bacterial test 10.85 9.40 14 109788 1229 46575031
Pseudomonal sepsis 10.85 9.40 18 109784 1984 46574276
Pituitary tumour 10.78 9.40 12 109790 903 46575357
Wheezing 10.77 9.40 181 109621 53205 46523055
Genital rash 10.75 9.40 9 109793 475 46575785
Dry eye 10.71 9.40 36 109766 30286 46545974
Burning sensation 10.64 9.40 155 109647 44256 46532004
Oedema peripheral 10.63 9.40 290 109512 159416 46416844
Herpes zoster meningoencephalitis 10.60 9.40 7 109795 256 46576004
Activated partial thromboplastin time prolonged 10.60 9.40 38 109764 6851 46569409
Dry skin 10.57 9.40 145 109657 40871 46535389
Therapy cessation 10.55 9.40 30 109772 26599 46549661
Accidental exposure to product 10.54 9.40 21 109781 21060 46555200
Dyskinesia 10.45 9.40 34 109768 28891 46547369
Blood gonadotrophin decreased 10.37 9.40 3 109799 12 46576248
Rhabdomyolysis 10.36 9.40 57 109745 41852 46534408
Excessive skin 10.29 9.40 5 109797 100 46576160
Nephrolithiasis 10.29 9.40 121 109681 32930 46543330
Intestinal stenosis 10.25 9.40 20 109782 2501 46573759
Vaccination site inflammation 10.15 9.40 4 109798 47 46576213
Pneumopericardium 10.00 9.40 4 109798 49 46576211
Viral infection 10.00 9.40 112 109690 30123 46546137
Large intestinal ulcer haemorrhage 9.98 9.40 5 109797 107 46576153
Loss of consciousness 9.91 9.40 187 109615 108051 46468209
Blood thyroid stimulating hormone decreased 9.89 9.40 26 109776 3963 46572297
Antithrombin III decreased 9.87 9.40 7 109795 288 46575972
Palmar-plantar erythrodysaesthesia syndrome 9.70 9.40 21 109781 20430 46555830
Blood immunoglobulin E increased 9.69 9.40 16 109786 1757 46574503
Live birth 9.67 9.40 49 109753 10281 46565979
Blood pH decreased 9.67 9.40 20 109782 2607 46573653
Vulval haemorrhage 9.67 9.40 3 109799 16 46576244
Multiple endocrine neoplasia Type 1 9.67 9.40 3 109799 16 46576244
Nervous system disorder 9.63 9.40 68 109734 16061 46560199
Respiratory tract congestion 9.57 9.40 57 109745 12707 46563553
Nasal polyps 9.56 9.40 18 109784 2192 46574068
Overweight 9.53 9.40 22 109780 3091 46573169
Vulvovaginal discomfort 9.48 9.40 18 109784 2206 46574054
Portal venous gas 9.46 9.40 4 109798 57 46576203
Drug level decreased 9.43 9.40 33 109769 5879 46570381
Coronary artery disease 9.42 9.40 44 109758 33708 46542552
Medication error 9.42 9.40 39 109763 30872 46545388

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Adrenal insufficiency 191.50 9.77 171 67351 10292 29874664
Infusion related reaction 177.71 9.77 324 67198 40240 29844716
Completed suicide 166.36 9.77 16 67506 99476 29785480
Craniopharyngioma 164.24 9.77 50 67472 260 29884696
Toxicity to various agents 163 9.77 99 67423 177084 29707872
Drug abuse 146.06 9.77 10 67512 82062 29802894
Adrenocortical insufficiency acute 143.84 9.77 67 67455 1270 29883686
Graft loss 143.82 9.77 59 67463 811 29884145
Death 138.31 9.77 384 67138 356899 29528057
Blood pressure fluctuation 128.26 9.77 177 67345 17326 29867630
Serum sickness 125.31 9.77 67 67455 1723 29883233
Febrile bone marrow aplasia 114.99 9.77 115 67407 7982 29876974
Hypofibrinogenaemia 99.76 9.77 56 67466 1589 29883367
Colitis ulcerative 81.29 9.77 129 67393 14305 29870651
Hypopituitarism 74.67 9.77 46 67476 1556 29883400
Frequent bowel movements 69.22 9.77 90 67432 8315 29876641
Leukoencephalopathy 68.48 9.77 63 67459 3939 29881017
Intentional overdose 63.50 9.77 9 67513 41472 29843484
Drug interaction 63.27 9.77 234 67288 199334 29685622
Febrile neutropenia 62.96 9.77 434 67088 106259 29778697
Off label use 62.64 9.77 846 66676 248444 29636512
Heart rate irregular 56.28 9.77 100 67422 12159 29872797
Product use issue 55.40 9.77 228 67294 45788 29839168
Pituitary tumour benign 52.07 9.77 29 67493 810 29884146
Insulin-like growth factor decreased 50.60 9.77 20 67502 248 29884708
Steroid withdrawal syndrome 50.52 9.77 19 67503 204 29884752
Tendon pain 49.62 9.77 43 67479 2484 29882472
Colitis 46.40 9.77 164 67358 30656 29854300
Septic shock 46.30 9.77 273 67249 63334 29821622
Diabetes insipidus 45.80 9.77 39 67483 2200 29882756
Interstitial lung disease 45.70 9.77 41 67481 60156 29824800
Hypertriglyceridaemia 45.08 9.77 72 67450 8026 29876930
Tendon disorder 44.95 9.77 39 67483 2257 29882699
Pseudostroke 44.61 9.77 12 67510 36 29884920
Arthralgia 44.55 9.77 485 67037 135306 29749650
Myocardial infarction 41.95 9.77 144 67378 125481 29759475
Tendon rupture 40.97 9.77 64 67458 7000 29877956
Impaired quality of life 40.73 9.77 31 67491 1488 29883468
Drug specific antibody present 40.54 9.77 35 67487 2012 29882944
Overdose 38.41 9.77 83 67439 84254 29800702
Neoplasm recurrence 37.13 9.77 32 67490 1835 29883121
Cortisol decreased 36.89 9.77 24 67498 894 29884062
Lichen planus 35.37 9.77 23 67499 856 29884100
Renal impairment 35 9.77 87 67435 84097 29800859
Crohn's disease 34.90 9.77 46 67476 4306 29880650
Suicide attempt 34.36 9.77 20 67502 36677 29848279
Glioma 34.36 9.77 16 67506 303 29884653
Insulin-like growth factor increased 34.15 9.77 24 67498 1017 29883939
Hypertrophic cardiomyopathy 34.12 9.77 23 67499 910 29884046
Hypophysitis 33.12 9.77 30 67492 1838 29883118
Pneumoretroperitoneum 32.23 9.77 10 67512 56 29884900
Body temperature fluctuation 32.06 9.77 25 67497 1244 29883712
Mucosal inflammation 32.01 9.77 145 67377 30349 29854607
Acute kidney injury 31.73 9.77 431 67091 273411 29611545
Epiphysiolysis 31.57 9.77 11 67511 93 29884863
Intentional product use issue 30.89 9.77 163 67359 36277 29848679
Fistula 30.53 9.77 47 67475 5075 29879881
Meningitis candida 30.21 9.77 10 67512 71 29884885
Condition aggravated 29.77 9.77 456 67066 137410 29747546
Pelvic abscess 29.05 9.77 21 67501 931 29884025
Pituitary haemorrhage 28.00 9.77 12 67510 185 29884771
Fall 27.78 9.77 269 67253 181603 29703353
Adrenocorticotropic hormone deficiency 26.80 9.77 15 67507 423 29884533
Adrenal suppression 26.55 9.77 17 67505 616 29884340
Cardiac failure 26.24 9.77 98 67424 83320 29801636
Neurotoxicity 26.05 9.77 77 67445 13105 29871851
Inappropriate schedule of product administration 26.04 9.77 166 67356 39562 29845394
Drug hypersensitivity 25.88 9.77 252 67270 68267 29816689
Flushing 25.74 9.77 133 67389 29359 29855597
Idiopathic intracranial hypertension 25.43 9.77 16 67506 562 29884394
Growth retardation 25.10 9.77 24 67498 1576 29883380
Cardiac failure congestive 24.74 9.77 102 67420 84305 29800651
Thermophobia 24.68 9.77 9 67513 88 29884868
Cardio-respiratory arrest 23.98 9.77 59 67463 57247 29827709
Faecal calprotectin increased 23.11 9.77 20 67502 1153 29883803
Anaphylactic reaction 22.92 9.77 124 67398 27858 29857098
Myelopathy 22.89 9.77 25 67497 1922 29883034
Stevens-Johnson syndrome 22.72 9.77 89 67433 17467 29867489
Onychoclasis 22.52 9.77 23 67499 1636 29883320
Thyroxine free decreased 22.29 9.77 11 67511 238 29884718
Periorbital infection 21.92 9.77 9 67513 124 29884832
Anaemia 21.72 9.77 334 67188 207658 29677298
Cholangitis infective 21.49 9.77 11 67511 258 29884698
Chorioretinopathy 21.31 9.77 21 67501 1431 29883525
Blood growth hormone increased 21.16 9.77 10 67512 196 29884760
Blood growth hormone decreased 20.98 9.77 6 67516 24 29884932
Rash erythematous 20.82 9.77 103 67419 22349 29862607
Chills 20.38 9.77 251 67271 72087 29812869
Optic nerve disorder 20.33 9.77 14 67508 574 29884382
Otitis media acute 20.16 9.77 12 67510 381 29884575
Sedation 20.02 9.77 6 67516 16367 29868589
Bronchial haemorrhage 19.81 9.77 15 67507 714 29884242
Perioral dermatitis 19.70 9.77 8 67514 107 29884849
Hyperbilirubinaemia 19.63 9.77 83 67439 16859 29868097
Klebsiella infection 19.50 9.77 46 67476 6841 29878115
Blood creatine phosphokinase increased 19.26 9.77 44 67478 43804 29841152
Pituitary tumour recurrent 19.23 9.77 7 67515 68 29884888
Abdominal pain 19.17 9.77 420 67102 135234 29749722
Blood thyroid stimulating hormone decreased 18.98 9.77 22 67500 1805 29883151
Pouchitis 18.93 9.77 14 67508 643 29884313
Shared psychotic disorder 18.84 9.77 5 67517 14 29884942
Anal inflammation 18.72 9.77 11 67511 341 29884615
Gastrointestinal anastomotic leak 18.54 9.77 11 67511 347 29884609
Musculoskeletal injury 18.46 9.77 8 67514 127 29884829
Hypogonadism 18.05 9.77 19 67503 1400 29883556
Renal failure 17.92 9.77 195 67327 128771 29756185
Cryptococcal fungaemia 17.92 9.77 7 67515 84 29884872
Hallucination 17.91 9.77 54 67468 49005 29835951
Syncope 17.86 9.77 115 67407 84788 29800168
Dermatitis diaper 17.74 9.77 10 67512 286 29884670
Splenic peliosis 17.69 9.77 5 67517 19 29884937
Candida infection 17.60 9.77 75 67447 15287 29869669
Glioblastoma multiforme 17.59 9.77 15 67507 848 29884108
Gastrointestinal haemorrhage 17.56 9.77 113 67409 83333 29801623
Atrial fibrillation 16.87 9.77 159 67363 107965 29776991
Subdural haematoma 16.84 9.77 11 67511 18961 29865995
Mantle cell lymphoma stage III 16.58 9.77 5 67517 25 29884931
Lacrimal duct neoplasm 16.58 9.77 5 67517 25 29884931
Bone cyst 16.58 9.77 12 67510 533 29884423
Joint ankylosis 16.56 9.77 10 67512 326 29884630
Posturing 16.56 9.77 12 67510 534 29884422
Neuroleptic malignant syndrome 16.55 9.77 8 67514 16287 29868669
Anal fistula 16.38 9.77 31 67491 3955 29881001
Gastrointestinal inflammation 16.31 9.77 26 67496 2893 29882063
Astrocytoma 16.26 9.77 8 67514 172 29884784
Body height below normal 16.24 9.77 9 67513 249 29884707
Cerebrospinal fluid leakage 16.15 9.77 11 67511 443 29884513
Symptom masked 15.95 9.77 11 67511 452 29884504
Intentional product misuse 15.87 9.77 34 67488 34633 29850323
Congenital cardiovascular anomaly 15.65 9.77 8 67514 187 29884769
Thyroxine decreased 15.51 9.77 7 67515 123 29884833
Secondary adrenocortical insufficiency 15.47 9.77 15 67507 1002 29883954
Posterior reversible encephalopathy syndrome 15.46 9.77 49 67473 8658 29876298
Aggression 15.44 9.77 38 67484 36869 29848087
Hospitalisation 15.32 9.77 50 67472 44269 29840687
Morganella infection 15.31 9.77 10 67512 375 29884581
Pituitary tumour 15.21 9.77 11 67511 488 29884468
Product quality issue 15.20 9.77 12 67510 18762 29866194
Cushingoid 15.08 9.77 23 67499 2464 29882492
Perirectal abscess 15.01 9.77 18 67504 1531 29883425
Bronchiectasis 14.99 9.77 35 67487 5169 29879787
Addison's disease 14.87 9.77 4 67518 12 29884944
Extrapyramidal disorder 14.86 9.77 3 67519 10690 29874266
Proctitis 14.76 9.77 21 67501 2113 29882843
Trichosporon infection 14.65 9.77 12 67510 641 29884315
Pharyngitis bacterial 14.59 9.77 5 67517 40 29884916
Aplastic anaemia 14.54 9.77 36 67486 5520 29879436
Short-bowel syndrome 14.44 9.77 8 67514 221 29884735
Lichenification 14.39 9.77 9 67513 313 29884643
Nervous system disorder 14.35 9.77 63 67459 13006 29871950
Angina pectoris 14.32 9.77 28 67494 29490 29855466
Epidural lipomatosis 14.22 9.77 8 67514 228 29884728
Hyperkalaemia 14.09 9.77 89 67433 65921 29819035
Tendonitis 14.07 9.77 45 67477 7991 29876965
Coronary artery disease 13.98 9.77 61 67461 49651 29835305
Anaplastic astrocytoma 13.92 9.77 7 67515 158 29884798
Kounis syndrome 13.91 9.77 18 67504 1655 29883301
Erythema 13.67 9.77 248 67274 77203 29807753
Cerebral haemorrhage 13.64 9.77 34 67488 32853 29852103
Intestinal stenosis 13.55 9.77 19 67503 1886 29883070
Dactylitis 13.55 9.77 10 67512 458 29884498
Diarrhoea haemorrhagic 13.52 9.77 36 67486 5769 29879187
Phaeochromocytoma crisis 13.44 9.77 4 67518 19 29884937
Proteus infection 13.40 9.77 12 67510 724 29884232
Adenoidal hypertrophy 13.31 9.77 6 67516 105 29884851
Feeling cold 13.27 9.77 49 67473 9350 29875606
Prothrombin level abnormal 13.26 9.77 6 67516 106 29884850
Intentional self-injury 13.21 9.77 7 67515 13525 29871431
Lactic acidosis 13.16 9.77 32 67490 31181 29853775
Gastroenteritis 13.12 9.77 62 67460 13204 29871752
Rectal abscess 13.03 9.77 13 67509 899 29884057
Shunt malfunction 12.92 9.77 7 67515 185 29884771
Transient aphasia 12.87 9.77 6 67516 114 29884842
Blood luteinising hormone decreased 12.77 9.77 6 67516 116 29884840
Blood corticotrophin increased 12.72 9.77 5 67517 61 29884895
Hypothalamo-pituitary disorder 12.70 9.77 11 67511 635 29884321
Renal disorder 12.67 9.77 21 67501 23563 29861393
Tracheobronchitis 12.43 9.77 13 67509 951 29884005
Mean cell volume decreased 12.35 9.77 14 67508 1121 29883835
Diplegia 12.28 9.77 13 67509 964 29883992
Eczema 12.16 9.77 61 67461 13308 29871648
Pulmonary arterial hypertension 12.14 9.77 3 67519 9298 29875658
Hypersensitivity 12.13 9.77 180 67342 53848 29831108
Pyrexia 12.12 9.77 794 66728 293695 29591261
Hyperthyroidism 12.10 9.77 43 67479 8055 29876901
Myelitis transverse 12.03 9.77 13 67509 987 29883969
Skin injury 12 9.77 13 67509 990 29883966
Graft versus host disease 11.97 9.77 50 67472 10100 29874856
Strongyloidiasis 11.89 9.77 20 67502 2326 29882630
Antibody test abnormal 11.87 9.77 6 67516 137 29884819
Retinal scar 11.85 9.77 7 67515 219 29884737
Foetal exposure during pregnancy 11.79 9.77 43 67479 36828 29848128
Clostridium difficile infection 11.63 9.77 68 67454 15715 29869241
White blood cell count decreased 11.62 9.77 127 67395 83820 29801136
Abdominal abscess 11.61 9.77 27 67495 3977 29880979
Hyperamylasaemia 11.58 9.77 10 67512 575 29884381
Multiple organ dysfunction syndrome 11.45 9.77 204 67318 63283 29821673
Contraindicated product prescribed 11.34 9.77 8 67514 341 29884615
Perineal pain 11.29 9.77 10 67512 595 29884361
Leptotrichia infection 11.28 9.77 5 67517 84 29884872
Hepatitis C 11.26 9.77 8 67514 13197 29871759
Peptic ulcer haemorrhage 11.23 9.77 9 67513 466 29884490
Cortisol abnormal 11.16 9.77 4 67518 37 29884919
Coma 11.15 9.77 50 67472 40399 29844557
Clostridium test positive 11.06 9.77 18 67504 2038 29882918
Oxygen saturation abnormal 10.98 9.77 13 67509 1091 29883865
Heart rate decreased 10.96 9.77 83 67439 20911 29864045
Blood culture positive 10.95 9.77 30 67492 4889 29880067
Feeling hot 10.92 9.77 66 67456 15438 29869518
Hepatic function abnormal 10.89 9.77 53 67469 41892 29843064
Vomiting projectile 10.79 9.77 10 67512 631 29884325
Spondylolisthesis 10.73 9.77 11 67511 786 29884170
Gonadotrophin deficiency 10.71 9.77 4 67518 42 29884914
Electrocardiogram QT prolonged 10.68 9.77 43 67479 35792 29849164
Tachycardia 10.62 9.77 229 67293 73510 29811446
Reaction to excipient 10.44 9.77 8 67514 388 29884568
Glucocorticoid deficiency 10.38 9.77 7 67515 277 29884679
Cerebral infarction 10.38 9.77 28 67494 26345 29858611
Suicidal ideation 10.35 9.77 44 67478 36070 29848886
Osteolysis 10.28 9.77 15 67507 1545 29883411
Somnolence 10.20 9.77 155 67367 96608 29788348
Gastroenterostomy 10.16 9.77 4 67518 49 29884907
Sepsis 10.16 9.77 415 67107 145980 29738976
Blood creatinine increased 10.11 9.77 145 67377 91230 29793726
Depressed level of consciousness 10.09 9.77 48 67474 38174 29846782
Eczema herpeticum 10.06 9.77 5 67517 110 29884846
Adenoidectomy 10.02 9.77 4 67518 51 29884905
Drug level below therapeutic 9.98 9.77 23 67499 3369 29881587
Aphthous ulcer 9.97 9.77 26 67496 4115 29880841
Paraesthesia 9.95 9.77 175 67347 54152 29830804
Vitamin E deficiency 9.95 9.77 3 67519 15 29884941
Blood follicle stimulating hormone decreased 9.95 9.77 4 67518 52 29884904
Functional gastrointestinal disorder 9.83 9.77 17 67505 2022 29882934
Superior sagittal sinus thrombosis 9.79 9.77 7 67515 305 29884651
Pallor 9.77 9.77 81 67441 20968 29863988

Pharmacologic Action:

SourceCodeDescription
ATC A01AC03 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC A07EA02 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC C05AA01 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AA02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, weak (group I)
ATC D07XA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, weak, other combinations
ATC H02AB09 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC S01BA02 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CB03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA01 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC D07BA04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, weak, combinations with antiseptics
ATC D07CA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, weak, combinations with antibiotics
ATC R01AD60 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC S01BB01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids and mydriatics in combination
ATC S01CA03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S02CA03 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03CA04 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic agents
CHEBI has role CHEBI:50857 anti-allergic agents
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:77746 h. sapiens metabolites
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Proctitis indication 3951002 DOID:3127
Keratitis indication 5888003 DOID:4677
Tinea pedis indication 6020002 DOID:12403
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Chronic ulcerative proctitis indication 52231000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Ulcerative colitis indication 64766004 DOID:8577
Löffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Hemorrhoids indication 70153002 DOID:9746
Transfusion reaction due to serum protein reaction indication 72284000
Acquired thrombocytopenia indication 74576004 DOID:11126
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Tinea corporis indication 84849002
Autoimmune disease indication 85828009
Corneal abrasion indication 85848002
Infective otitis externa indication 86981007 DOID:9463
Infection by larvae of Trichinella spiralis indication 88264003
Acne vulgaris indication 88616000
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Tinea cruris indication 399029005
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Recurrent herpes simplex labialis indication 402892009
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Aphthous ulcer of mouth indication 426965005 DOID:9663
Allergic conjunctivitis indication 473460002 DOID:11204
Post traumatic osteoarthritis indication 699262001
Itching of ear indication 699392007
Inflammatory dermatosis indication 703938007
Diagnostic Test for Cushing's Syndrome indication
Synovitis due to Osteoarthritis indication
Minor Bacterial Skin Infections indication
Gingival Disorders indication
Systemic Dermatomyositis indication
Erythroblastic Anemia indication
Mastoidectomy Cavity Infections indication
Staphylococcus Aureus Otitis Externa indication
Superficial Ocular Infection indication
Transfusion Reaction Urticaria indication
Post-Op Ocular Inflammation indication
Chronic purulent otitis media off-label use 38394007 DOID:14247
Respiratory distress syndrome in the newborn off-label use 46775006
Adrenoleukodystrophy off-label use 65389002 DOID:10588
Pityriasis simplex off-label use 200767005
Congenital adrenal hyperplasia off-label use 237751000
Allergic otitis externa off-label use 405821001
Itching of skin off-label use 418363000
Congenital Pituitary Hypoplasia off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Otitis Externa Eczema off-label use
Otitis Externa Seborrhea off-label use
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Bacterial septicemia contraindication 10001005 DOID:0040085
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Measles contraindication 14189004 DOID:8622
Esophagitis contraindication 16761005 DOID:11963
Mood swings contraindication 18963009
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Cirrhosis of liver contraindication 19943007 DOID:5082
Herpes zoster auricularis contraindication 21954000 DOID:9210
Glaucoma contraindication 23986001 DOID:1686
Abscess of intestine contraindication 24557004
Acute tuberculosis contraindication 25629007
Shock contraindication 27942005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Bullous myringitis contraindication 33528003 DOID:13791
Severe myopia contraindication 34187009
Hyperthyroidism contraindication 34486009 DOID:7998
Gastrointestinal fistula contraindication 37831005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Duodenal ulcer disease contraindication 51868009 DOID:1724
Perforation of tympanic membrane contraindication 60442001
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Third degree burn injury contraindication 80247002
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Disorder of mucous membrane contraindication 95351003
Bilateral cataracts contraindication 95722004
Open wound contraindication 125643001
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Tuberculosis of ear contraindication 186269001
Ophthalmic herpes simplex contraindication 186542001
Heart block contraindication 233916004
Anastomosis of intestine contraindication 235407009
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Telangiectasia disorder contraindication 247479008
Diverticulitis of gastrointestinal tract contraindication 271366000
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Infective otitis media contraindication 312218008
Skin irritation contraindication 367466007
Vaccinia keratitis contraindication 397552005
Gastric ulcer contraindication 397825006 DOID:10808
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Blister contraindication 417237009
Denuded skin contraindication 418242004
Exposure to varicella contraindication 444453009

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.31 acidic
pKa2 13.65 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.50 WOMBAT-PK CHEMBL
Nitric oxide synthase, inducible Enzyme IC50 8 WOMBAT-PK
Corticosteroid-binding globulin Secreted Ki 7.88 WOMBAT-PK
Annexin A1 Cytosolic other WOMBAT-PK
Sex hormone-binding globulin Secreted Kd 6.20 CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor AGONIST IC50 9.95 IUPHAR
Glucocorticoid receptor Transcription factor Kd 7.37 CHEMBL

External reference:

IDSource
4017941 VUID
N0000146291 NUI
D00088 KEGG_DRUG
4017941 VANDF
C0020268 UMLSCUI
CHEBI:17650 CHEBI
HCY PDB_CHEM_ID
CHEMBL389621 ChEMBL_ID
5754 PUBCHEM_CID
DB00741 DRUGBANK_ID
D006854 MESH_DESCRIPTOR_UI
2868 IUPHAR_LIGAND_ID
38 INN_ID
WI4X0X7BPJ UNII
202643 RXNORM
174 MMSL
2500 MMSL
4837 MMSL
d00254 MMSL
002147 NDDF
16602005 SNOMEDCT_US
396458002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CORTEF HUMAN PRESCRIPTION DRUG LABEL 1 0009-0012 TABLET 5 mg ORAL NDA 15 sections
CORTEF HUMAN PRESCRIPTION DRUG LABEL 1 0009-0031 TABLET 10 mg ORAL NDA 15 sections
CORTEF HUMAN PRESCRIPTION DRUG LABEL 1 0009-0044 TABLET 20 mg ORAL NDA 15 sections
CIPROHC HUMAN PRESCRIPTION DRUG LABEL 2 0065-8531 SUSPENSION 10 mg AURICULAR (OTIC) NDA 16 sections
Aquanil HC HUMAN OTC DRUG LABEL 1 0096-0732 LOTION 0.01 g TOPICAL OTC monograph not final 10 sections
Good Sense Anti Itch HUMAN OTC DRUG LABEL 1 0113-0471 OINTMENT 1 g TOPICAL OTC monograph not final 13 sections
good sense anti itch HUMAN OTC DRUG LABEL 1 0113-0541 CREAM 1 g TOPICAL OTC monograph not final 13 sections
basic care hydrocortisone HUMAN OTC DRUG LABEL 1 0113-0793 CREAM 1 g TOPICAL OTC monograph not final 13 sections
Good Sense Anti Itch HUMAN OTC DRUG LABEL 1 0113-0973 CREAM 1 g TOPICAL OTC monograph not final 13 sections
good sense anti itch HUMAN OTC DRUG LABEL 1 0113-1369 CREAM 1 g TOPICAL OTC monograph not final 13 sections
Basic Case Hydrocortisone Anti-Itch HUMAN OTC DRUG LABEL 1 0113-7006 CREAM 1 g TOPICAL OTC monograph not final 13 sections
basic care hydrocortisone HUMAN OTC DRUG LABEL 1 0113-7369 CREAM 1 g TOPICAL OTC monograph not final 13 sections
HYDROCORTISONE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1696 TABLET 5 mg ORAL ANDA 14 sections
HYDROCORTISONE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1697 TABLET 10 mg ORAL ANDA 14 sections
HYDROCORTISONE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1700 TABLET 20 mg ORAL ANDA 14 sections
HYDROCORTISONE HUMAN OTC DRUG LABEL 1 0168-0014 CREAM 5 mg TOPICAL OTC monograph final 9 sections
hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0168-0015 CREAM 10 mg TOPICAL ANDA 19 sections
HYDROCORTISONE HUMAN OTC DRUG LABEL 1 0168-0016 OINTMENT 5 mg TOPICAL OTC monograph final 9 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0168-0020 OINTMENT 10 mg TOPICAL ANDA 18 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0168-0080 CREAM 25 mg TOPICAL ANDA 17 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0168-0146 OINTMENT 25 mg TOPICAL ANDA 17 sections
HYDROCORTISONE HUMAN OTC DRUG LABEL 1 0168-0181 OINTMENT 10 mg TOPICAL OTC monograph not final 9 sections
Hydrocortisone HUMAN PRESCRIPTION DRUG LABEL 1 0168-0288 LOTION 25 mg TOPICAL ANDA 18 sections
Texacort HUMAN PRESCRIPTION DRUG LABEL 1 0178-0455 SOLUTION 25 mg TOPICAL ANDA 20 sections
Hydrocortisone HUMAN OTC DRUG LABEL 1 0179-8016 CREAM 0.50 g TOPICAL OTC monograph not final 15 sections
KAISER PERMANENTEHydrocortisone HUMAN OTC DRUG LABEL 1 0179-8711 OINTMENT 1 g TOPICAL OTC monograph not final 15 sections
Xerese HUMAN PRESCRIPTION DRUG LABEL 2 0187-5104 CREAM 10 mg TOPICAL NDA 26 sections
Ala Quin HUMAN PRESCRIPTION DRUG LABEL 2 0316-0123 CREAM 5 mg TOPICAL unapproved drug other 18 sections
Alacort HUMAN PRESCRIPTION DRUG LABEL 1 0316-0126 CREAM 10 mg TOPICAL ANDA 19 sections
Alacort HUMAN PRESCRIPTION DRUG LABEL 1 0316-0128 CREAM 25 mg TOPICAL ANDA 19 sections