atropine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 260 51-55-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • atropine
  • (+/-)-Atropine
  • atropin
  • atropinum sulphuricum
  • DL-Hyoscyamine
  • tropine tropate
  • atropine sulfate
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine.
  • Molecular weight: 289.38
  • Formula: C17H23NO3
  • CLOGP: 1.30
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -2.06
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 139 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 57 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.03 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.61 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.310 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 3.381 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 3.105 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 9.162 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 89.930 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 85.910 % High 1
herg hERG pIC50 4.469 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.838 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.097 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 90.320 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IRAK4,ITK,JAK3,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,SIK3,TEK,TGFBR1 35
kinase-selectivity-class AXL,CAMK2D,CDK4,EIF2AK3,PDK4 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.279 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.547 High 1
mh-clint Mouse hepatocyte intrinsic clearance 188.799 High 1
mppb Mouse plasma protein binding (% unbound) 91.340 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 6.871 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 91.360 % High 1
rat-kpuu-brain Rat brain Kpuu 0.049 % High 1
rh-clint Rat hepatocyte intrinsic clearance 87.498 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.180 % High 1
rppb Rat plasma protein binding (% unbound) 85.110 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 903.649 uM High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 15, 1960 FDA GD SEARLE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 300.65 12.78 162 23552 37808 90566925
Stress cardiomyopathy 189.91 12.78 85 23629 13270 90591463
Hypotension 144.10 12.78 284 23430 325113 90279620
Death 141.43 12.78 345 23369 456206 90148527
Paraesthesia oral 121.32 12.78 85 23629 31574 90573159
Bradycardia 114.67 12.78 125 23589 83722 90521011
Joint swelling 110.68 12.78 5 23709 503295 90101438
Chronic sinusitis 105.67 12.78 70 23644 23732 90581001
Therapy interrupted 104.41 12.78 94 23620 50014 90554719
Female genital tract fistula 103.00 12.78 62 23652 17806 90586927
Vaginal flatulence 94.63 12.78 52 23662 12586 90592147
Radiculopathy 90.92 12.78 58 23656 18447 90586286
Proctitis 88.09 12.78 53 23661 15206 90589527
Cardiac arrest 87.60 12.78 122 23592 104813 90499920
Procedural pain 86.63 12.78 71 23643 33289 90571444
Anticholinergic syndrome 86.47 12.78 31 23683 2712 90602021
Vaginal discharge 83.41 12.78 56 23658 19408 90585325
Anterior spinal artery syndrome 81.46 12.78 17 23697 182 90604551
Dehydration 79.10 12.78 164 23550 194283 90410450
Arthropathy 73.38 12.78 6 23708 366236 90238497
Colitis 71.77 12.78 90 23624 69852 90534881
Therapy cessation 71.41 12.78 66 23648 36295 90568438
Glossodynia 68.15 12.78 4 23710 321775 90282958
Synovitis 67.18 12.78 5 23709 329747 90274986
Wound 66.58 12.78 3 23711 302977 90301756
Contraindicated product administered 64.81 12.78 5 23709 320134 90284599
Systemic lupus erythematosus 64.67 12.78 9 23705 361887 90242846
Constipation 64.45 12.78 190 23524 280205 90324528
Rectal haemorrhage 64.31 12.78 93 23621 82651 90522082
Sedation complication 63.75 12.78 45 23669 16899 90587834
Creatinine renal clearance increased 63.55 12.78 26 23688 3255 90601478
Drug intolerance 60.22 12.78 21 23693 447570 90157163
Rhythm idioventricular 59.62 12.78 15 23699 384 90604349
Peripheral swelling 58.00 12.78 18 23696 413088 90191645
Dysarthria 57.32 12.78 71 23643 54411 90550322
Nasopharyngitis 56.69 12.78 18 23696 407086 90197647
Arthralgia 56.16 12.78 73 23641 778449 89826284
Oral candidiasis 55.81 12.78 57 23657 35398 90569335
Diarrhoea 53.69 12.78 424 23290 938766 89665967
Apnoea 52.54 12.78 32 23682 9382 90595351
Spinal cord injury 52.49 12.78 17 23697 1092 90603641
Abdominal discomfort 52.30 12.78 30 23684 477298 90127435
Renal function test abnormal 52.22 12.78 29 23685 7162 90597571
Abdominal pain 51.93 12.78 223 23491 395498 90209235
Haematochezia 51.20 12.78 77 23637 70836 90533897
Treatment failure 51.02 12.78 9 23705 303919 90300814
Creatinine renal clearance decreased 50.69 12.78 41 23673 18858 90585875
Rheumatoid arthritis 50.53 12.78 16 23698 362598 90242135
Lower respiratory tract infection 50.48 12.78 4 23710 250655 90354078
Swelling 49.35 12.78 24 23690 419034 90185699
Respiratory depression 48.72 12.78 37 23677 15538 90589195
Sedation 47.84 12.78 61 23653 48110 90556623
Psoriatic arthropathy 47.84 12.78 3 23711 228332 90376401
Hepatic enzyme increased 46.69 12.78 18 23696 360718 90244015
Toxicity to various agents 46.38 12.78 173 23541 287673 90317060
Haemodynamic instability 46.08 12.78 32 23682 11707 90593026
Endophthalmitis 45.67 12.78 23 23691 4662 90600071
Cardiogenic shock 45.33 12.78 43 23671 24425 90580308
Product use issue 45.18 12.78 15 23699 329904 90274829
Alopecia 45.12 12.78 38 23676 495033 90109700
BRASH syndrome 43.73 12.78 17 23697 1862 90602871
Ventricular fibrillation 43.13 12.78 33 23681 14011 90590722
Blood calcium decreased 42.99 12.78 46 23668 30136 90574597
Intentional product use issue 42.20 12.78 4 23710 216888 90387845
Discomfort 42.15 12.78 10 23704 274325 90330408
Disseminated intravascular coagulation 42.10 12.78 39 23675 21499 90583234
Weight increased 42 12.78 29 23685 417898 90186835
Schizencephaly 41.99 12.78 11 23703 332 90604401
Cerebral haemorrhage foetal 41.83 12.78 11 23703 337 90604396
Colitis ulcerative 41.47 12.78 64 23650 60202 90544531
Musculoskeletal stiffness 41.46 12.78 13 23701 296519 90308214
Mydriasis 41.18 12.78 33 23681 14979 90589754
Therapeutic product effect decreased 40.95 12.78 11 23703 277560 90327173
Neuropathy peripheral 40.62 12.78 102 23612 136868 90467865
Polydipsia 39.00 12.78 20 23694 4211 90600522
Fibromyalgia 37.13 12.78 5 23709 206264 90398469
Depressed level of consciousness 36.37 12.78 67 23647 72717 90532016
Duodenal ulcer perforation 36.17 12.78 7 23707 221281 90383452
Frequent bowel movements 35.77 12.78 58 23656 56877 90547856
Rash 33.72 12.78 102 23612 795998 89808735
Orthostatic hypotension 32.47 12.78 47 23667 41780 90562953
Ventricular tachycardia 32.30 12.78 36 23678 24672 90580061
Sinusitis 31.64 12.78 26 23688 343062 90261671
Coma 31.55 12.78 63 23651 72569 90532164
Irritable bowel syndrome 31.01 12.78 8 23706 207440 90397293
Seizure 30.88 12.78 99 23615 152530 90452203
Anterior chamber flare 30.60 12.78 7 23707 118 90604615
Respiratory failure 29.82 12.78 83 23631 118335 90486398
Sinus tachycardia 29.73 12.78 37 23677 28476 90576257
Multiple drug therapy 29.63 12.78 20 23694 6989 90597744
Pulmonary oedema 29.59 12.78 56 23658 62024 90542709
Enzyme induction 29.50 12.78 6 23708 56 90604677
Anorectal disorder 29.10 12.78 13 23701 2018 90602715
Drug monitoring procedure not performed 29.04 12.78 10 23704 777 90603956
Paralysis 28.89 12.78 24 23690 11454 90593279
Sinus arrest 28.41 12.78 13 23701 2133 90602600
Erythema 28.34 12.78 127 23587 229119 90375614
Drug interaction 28.28 12.78 145 23569 276308 90328425
Vasoplegia syndrome 27.97 12.78 14 23700 2800 90601933
Neuromuscular blockade 27.50 12.78 8 23706 358 90604375
Liver injury 26.62 12.78 6 23708 170561 90434172
Circulating anticoagulant positive 26.52 12.78 5 23709 30 90604703
Muscle injury 26.04 12.78 7 23707 176647 90428086
Ventricular asystole 26.01 12.78 6 23708 105 90604628
Infection 25.98 12.78 34 23680 362060 90242673
Blood cholesterol increased 25.88 12.78 11 23703 208001 90396732
Atrioventricular block complete 25.71 12.78 21 23693 9790 90594943
Febrile neutropenia 25.32 12.78 95 23619 158254 90446479
Hypovolaemia 25.25 12.78 23 23691 12408 90592325
Impaired healing 25.22 12.78 15 23699 234184 90370549
Blister 25.19 12.78 18 23696 254980 90349753
Wheezing 24.59 12.78 16 23698 238064 90366669
Sinus bradycardia 24.42 12.78 26 23688 16926 90587807
Hyperthermia malignant 24.17 12.78 10 23704 1288 90603445
Hypersensitivity 24.03 12.78 52 23662 454625 90150108
Corneal perforation 23.44 12.78 8 23706 605 90604128
Crohn's disease 23.32 12.78 15 23699 4836 90599897
Neuromuscular block prolonged 22.96 12.78 8 23706 644 90604089
Cardiac assistance device user 22.86 12.78 5 23709 68 90604665
Metabolic acidosis 22.64 12.78 47 23667 55629 90549104
Generalised tonic-clonic seizure 22.53 12.78 36 23678 34867 90569866
Somnolence 22.31 12.78 111 23603 208973 90395760
Intestinal obstruction 22.21 12.78 37 23677 37094 90567639
Agitation postoperative 22.18 12.78 4 23710 18 90604715
Aplastic anaemia 22.10 12.78 22 23692 13247 90591486
Surgery 22.02 12.78 41 23673 44846 90559887
Rebound psychosis 21.86 12.78 6 23708 217 90604516
Inflammation 21.34 12.78 10 23704 178582 90426151
Small intestinal obstruction 21.25 12.78 27 23687 21207 90583526
Ill-defined disorder 21.12 12.78 11 23703 184880 90419853
Mental status changes 20.91 12.78 40 23674 44639 90560094
Spleen congestion 20.82 12.78 5 23709 105 90604628
Urticaria 20.80 12.78 31 23683 312703 90292030
Gastrointestinal disorder 20.65 12.78 22 23692 256665 90348068
Balance disorder 20.57 12.78 64 23650 97016 90507717
Blood pressure systolic decreased 20.51 12.78 18 23696 9252 90595481
Hypopyon 20.32 12.78 8 23706 906 90603827
Choroidal detachment 20.32 12.78 6 23708 283 90604450
Purpura senile 19.57 12.78 7 23707 608 90604125
Night sweats 19.17 12.78 5 23709 128761 90475972
Bundle branch block left 18.84 12.78 16 23698 7869 90596864
Cardio-respiratory arrest 18.68 12.78 47 23667 63093 90541640
N-terminal prohormone brain natriuretic peptide 18.52 12.78 4 23710 51 90604682
Stomatitis 18.48 12.78 27 23687 274671 90330062
Pruritus 18.44 12.78 76 23638 541449 90063284
Anterior segment ischaemia 18.38 12.78 4 23710 53 90604680
Arteriospasm coronary 18.05 12.78 13 23701 5037 90599696
Pressure of speech 18.04 12.78 7 23707 763 90603970
Bursitis 17.98 12.78 6 23708 131648 90473085
Thrombocytopenic purpura 17.74 12.78 9 23705 1852 90602881
Vomiting 17.72 12.78 297 23417 787996 89816737
C-reactive protein increased 17.65 12.78 13 23701 181376 90423357
Serpiginous choroiditis 17.59 12.78 3 23711 9 90604724
Corneal oedema 17.56 12.78 9 23705 1892 90602841
Systolic dysfunction 17.55 12.78 9 23705 1895 90602838
Product dose omission issue 17.44 12.78 31 23683 291656 90313077
Fatigue 17.38 12.78 206 23508 1153817 89450916
Polyuria 17.38 12.78 17 23697 10023 90594710
Cardiomegaly 17.28 12.78 23 23691 18902 90585831
Hypokalaemia 17.22 12.78 74 23640 131042 90473691
Post procedural complication 17.17 12.78 23 23691 19019 90585714
Atrioventricular block second degree 17.15 12.78 12 23702 4440 90600293
Asthma 17.09 12.78 23 23691 242137 90362596
Overdose 17.01 12.78 84 23630 157625 90447108
Sciatica 17.00 12.78 3 23711 101379 90503354
pH body fluid abnormal 16.93 12.78 4 23710 78 90604655
Therapeutic product effect delayed 16.87 12.78 11 23703 3630 90601103
Ventricular extrasystoles 16.79 12.78 19 23695 13231 90591502
Supraventricular tachycardia 16.71 12.78 21 23693 16315 90588418
Urinary retention 16.70 12.78 33 23681 37711 90567022
Anaemia 16.69 12.78 153 23561 352649 90252084
Oliguria 16.57 12.78 17 23697 10607 90594126
Electrocardiogram QRS complex shortened 16.51 12.78 6 23708 546 90604187
Antipsychotic drug level increased 16.49 12.78 11 23703 3768 90600965
Shock 16.31 12.78 28 23686 28750 90575983
Tarsal tunnel syndrome 16.25 12.78 6 23708 571 90604162
Pain in extremity 16.11 12.78 62 23652 450467 90154266
Vitritis 15.96 12.78 8 23706 1606 90603127
Catatonia 15.95 12.78 13 23701 6043 90598690
Electrocardiogram ST segment elevation 15.88 12.78 11 23703 4005 90600728
Cognitive disorder 15.87 12.78 47 23667 69360 90535373
Neuralgia 15.73 12.78 29 23685 31471 90573262
Type 2 diabetes mellitus 15.71 12.78 18 23696 203226 90401507
Bronchospasm 15.68 12.78 23 23691 20686 90584047
Condition aggravated 15.44 12.78 92 23622 595453 90009280
Strabismus 15.36 12.78 9 23705 2459 90602274
Insomnia 15.34 12.78 41 23673 333433 90271300
Sudden infant death syndrome 15.32 12.78 5 23709 329 90604404
Pulseless electrical activity 15.23 12.78 15 23699 8917 90595816
Salivary hypersecretion 15.00 12.78 15 23699 9077 90595656
Gait inability 14.90 12.78 10 23704 146446 90458287
Sleep disorder 14.81 12.78 18 23696 198012 90406721
Haematuria 14.80 12.78 30 23684 34907 90569826
Respiratory arrest 14.59 12.78 29 23685 33282 90571451
Resuscitation 14.53 12.78 7 23707 1289 90603444
Road traffic accident 14.53 12.78 5 23709 107621 90497112
Myocardial ischaemia 14.52 12.78 18 23696 13796 90590937
Pulmonary fibrosis 14.50 12.78 5 23709 107498 90497235
Choroidal effusion 14.42 12.78 6 23708 783 90603950
Needle issue 14.39 12.78 18 23696 13916 90590817
Hyperhidrosis 14.27 12.78 72 23642 136233 90468500
Tachycardia 14.27 12.78 80 23634 157593 90447140
Hypophagia 14.22 12.78 30 23684 35907 90568826
Iris adhesions 14.12 12.78 5 23709 422 90604311
Chorioretinitis 14.11 12.78 6 23708 827 90603906
Failure to thrive 14.11 12.78 14 23700 8397 90596336
Drug hypersensitivity 14.01 12.78 68 23646 463541 90141192
Agitation 14.00 12.78 44 23670 67054 90537679
Opsoclonus myoclonus 13.97 12.78 4 23710 169 90604564
Atrioventricular block first degree 13.97 12.78 14 23700 8497 90596236
Retinal vascular occlusion 13.96 12.78 5 23709 436 90604297
Upper gastrointestinal haemorrhage 13.88 12.78 23 23691 22953 90581780
Nausea 13.83 12.78 384 23330 1109932 89494801
Judgement impaired 13.76 12.78 6 23708 879 90603854
Myocardial necrosis marker increased 13.71 12.78 8 23706 2170 90602563
Acute kidney injury 13.69 12.78 136 23578 320251 90284482
Memory impairment 13.65 12.78 19 23695 197225 90407508
Musculoskeletal pain 13.41 12.78 15 23699 171236 90433497
Dermatitis acneiform 13.38 12.78 12 23702 6342 90598391
Torsade de pointes 13.17 12.78 18 23696 15164 90589569
Unresponsive to stimuli 13.02 12.78 30 23684 38091 90566642
Peripheral venous disease 13.00 12.78 3 23711 83918 90520815
Hypoxia 12.89 12.78 45 23669 72354 90532379
Hypotony of eye 12.88 12.78 4 23710 224 90604509
Renal failure 12.88 12.78 68 23646 130939 90473794
Anaesthetic complication 12.79 12.78 8 23706 2457 90602276

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anticholinergic syndrome 94.20 12.73 33 19142 1556 42600604
Death 90.27 12.73 434 18741 470751 42131409
Cardiac arrest 72.40 12.73 155 19020 109165 42492995
Diarrhoea 65.27 12.73 391 18784 460458 42141702
Bradycardia 59.82 12.73 124 19051 85360 42516800
Hyperthermia malignant 58.37 12.73 27 19148 2631 42599529
Tachycardia 55.40 12.73 133 19042 100954 42501206
Dehydration 47.53 12.73 156 19019 141611 42460549
Pulse absent 45.89 12.73 31 19144 6296 42595864
Mydriasis 45.37 12.73 35 19140 8735 42593425
Corneal oedema 38.02 12.73 17 19158 1531 42600629
Therapy interrupted 37.29 12.73 48 19127 22202 42579958
Cholinergic syndrome 36.22 12.73 13 19162 658 42601502
Vasoplegia syndrome 34.77 12.73 19 19156 2636 42599524
Electrocardiogram QRS complex prolonged 34.03 12.73 25 19150 5798 42596362
Stress cardiomyopathy 28.59 12.73 17 19158 2768 42599392
Therapy cessation 28.01 12.73 40 19135 20410 42581750
Keratic precipitates 26.55 12.73 8 19167 232 42601928
Mouth ulceration 26.21 12.73 33 19142 14930 42587230
Compartment syndrome 25.99 12.73 17 19158 3272 42598888
Pupil fixed 25.89 12.73 14 19161 1903 42600257
Arteriospasm coronary 24.70 12.73 19 19156 4719 42597441
Dysarthria 24.66 12.73 55 19120 39752 42562408
Foot fracture 24.22 12.73 21 19154 6170 42595990
Ileus 24.13 12.73 36 19139 19103 42583057
Product use in unapproved indication 23.57 12.73 29 19146 184427 42417733
Intraocular pressure increased 23.52 12.73 21 19154 6412 42595748
Alopecia 23.49 12.73 45 19130 29231 42572929
Rebound psychosis 23.47 12.73 7 19168 196 42601964
Tendon disorder 23.14 12.73 16 19159 3373 42598787
Hypotension 21.99 12.73 194 18981 257437 42344723
Emotional disorder 21.88 12.73 20 19155 6294 42595866
Exostosis 21.82 12.73 19 19156 5612 42596548
Vomiting 21.64 12.73 212 18963 289511 42312649
Coma scale abnormal 20.99 12.73 17 19158 4548 42597612
Oral pain 20.83 12.73 27 19148 12569 42589591
Anaesthetic complication 20.68 12.73 11 19164 1446 42600714
Scleritis 20.49 12.73 9 19166 777 42601383
Hypertension 20.46 12.73 137 19038 167067 42435093
Blood pressure decreased 20.24 12.73 65 19110 58267 42543893
Dermatitis acneiform 20.23 12.73 21 19154 7718 42594442
Choroidal detachment 20.20 12.73 8 19167 532 42601628
Laryngospasm 20.06 12.73 12 19163 1976 42600184
Ankle fracture 20.04 12.73 17 19158 4849 42597311
Nausea 20.03 12.73 269 18906 396530 42205630
Acute pulmonary oedema 20.01 12.73 22 19153 8629 42593531
Blood creatinine decreased 19.80 12.73 15 19160 3643 42598517
Limb mass 19.79 12.73 9 19166 843 42601317
Rhabdomyolysis 19.43 12.73 78 19097 77941 42524219
Drug intolerance 19.43 12.73 6 19169 80418 42521742
Sinus tachycardia 19.41 12.73 34 19141 20619 42581541
Endophthalmitis 19.32 12.73 16 19159 4417 42597743
Ventricular tachycardia 19.05 12.73 42 19133 30118 42572042
Anterior chamber inflammation 18.74 12.73 7 19168 397 42601763
Prinzmetal angina 18.57 12.73 10 19165 1347 42600813
Corneal epithelium defect 18.44 12.73 7 19168 415 42601745
Hyperhidrosis 18.33 12.73 85 19090 90427 42511733
Atrioventricular block 18.12 12.73 22 19153 9593 42592567
Agitation postoperative 18.05 12.73 4 19171 32 42602128
Ventricular fibrillation 17.96 12.73 41 19134 30082 42572078
Surgery 17.87 12.73 30 19145 17586 42584574
Product delivery mechanism issue 17.61 12.73 6 19169 260 42601900
Foot deformity 17.46 12.73 16 19159 5052 42597108
Angle closure glaucoma 17.43 12.73 9 19166 1113 42601047
Salivary hypersecretion 17.39 12.73 23 19152 10920 42591240
Change of bowel habit 17.38 12.73 9 19166 1120 42601040
Hypoxic-ischaemic encephalopathy 17.10 12.73 16 19159 5186 42596974
Blood sodium increased 16.99 12.73 13 19162 3205 42598955
Shock 16.66 12.73 39 19136 29082 42573078
Neuromuscular block prolonged 15.85 12.73 7 19168 612 42601548
BRASH syndrome 15.82 12.73 10 19165 1815 42600345
Proteinuria 15.65 12.73 33 19142 22950 42579210
Nail bed inflammation 15.64 12.73 5 19170 177 42601983
Cardiogenic shock 15.47 12.73 43 19132 35597 42566563
Interstitial lung disease 15.44 12.73 8 19167 78454 42523706
Flushing 15.41 12.73 44 19131 36984 42565176
Retinal occlusive vasculitis 15.14 12.73 4 19171 71 42602089
Intestinal obstruction 15.13 12.73 36 19139 27122 42575038
Apnoea 14.94 12.73 18 19157 7785 42594375
Post procedural complication 14.90 12.73 23 19152 12567 42589593
Restrictive cardiomyopathy 14.57 12.73 7 19168 743 42601417
Respiration abnormal 14.39 12.73 13 19162 4029 42598131
Influenza 14.38 12.73 5 19170 62170 42539990
Electrocardiogram ST segment depression 14.32 12.73 11 19164 2726 42599434
Anaphylactic reaction 14.25 12.73 47 19128 42696 42559464
Decreased appetite 14.23 12.73 141 19034 192996 42409164
Anterior chamber flare 14.16 12.73 4 19171 92 42602068
Visual acuity tests abnormal 14.12 12.73 4 19171 93 42602067
Stoma site pain 14.11 12.73 7 19168 796 42601364
Anaphylactic shock 14.01 12.73 32 19143 23485 42578675
COVID-19 14.00 12.73 19 19156 115929 42486231
Fatigue 13.96 12.73 274 18901 435367 42166793
Intestinal pseudo-obstruction 13.90 12.73 10 19165 2245 42599915
Vertebral column mass 13.80 12.73 4 19171 101 42602059
Dysprosody 13.77 12.73 3 19172 22 42602138
Peritumoural oedema 13.77 12.73 3 19172 22 42602138
Loss of personal independence in daily activities 13.39 12.73 3 19172 49813 42552347
Sinus bradycardia 13.38 12.73 24 19151 14829 42587331
Nasopharyngitis 13.23 12.73 11 19164 83985 42518175
Intentional product use issue 13.16 12.73 8 19167 71825 42530335
Cataract subcapsular 13.14 12.73 6 19169 567 42601593
Tonic clonic movements 13.14 12.73 8 19167 1359 42600801
Therapeutic product effect incomplete 12.86 12.73 8 19167 70931 42531229
Peripheral swelling 12.82 12.73 13 19162 90257 42511903

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Stress cardiomyopathy 203.17 12.20 100 35452 15706 110538041
Death 188.92 12.20 572 34980 698297 109855450
Cardiac arrest 169.91 12.20 259 35293 196494 110357253
Therapy interrupted 168.99 12.20 135 35417 49687 110504060
Bradycardia 151.94 12.20 217 35335 155300 110398447
Anticholinergic syndrome 145.59 12.20 54 35498 4226 110549521
Hypotension 141.52 12.20 429 35123 523420 110030327
Therapy cessation 116.01 12.20 104 35448 44753 110508994
Macular degeneration 107.92 12.20 74 35478 21585 110532162
Paraesthesia oral 99.02 12.20 84 35468 33587 110520160
Chronic sinusitis 89.39 12.20 70 35482 25014 110528733
Female genital tract fistula 88.41 12.20 59 35493 16460 110537287
Vaginal flatulence 86.58 12.20 52 35500 12092 110541655
Diarrhoea 85.05 12.20 641 34911 1138864 109414883
Hyperthermia malignant 82.79 12.20 35 35517 3865 110549882
Nasopharyngitis 77.83 12.20 16 35536 394345 110159402
Anterior spinal artery syndrome 76.12 12.20 17 35535 205 110553542
Radiculopathy 75.56 12.20 57 35495 19279 110534468
Proctitis 75.40 12.20 54 35498 16873 110536874
Mydriasis 75.02 12.20 60 35492 22097 110531650
Vaginal discharge 74.92 12.20 55 35497 17853 110535894
Drug intolerance 73.32 12.20 20 35532 406492 110147255
Arthralgia 73.03 12.20 86 35466 779546 109774201
Procedural pain 71.97 12.20 72 35480 35493 110518254
Dehydration 69.80 12.20 223 35329 279288 110274459
Joint swelling 65.83 12.20 30 35522 442815 110110932
Vasoplegia syndrome 65.71 12.20 33 35519 5406 110548341
Contraindicated product administered 63.92 12.20 4 35548 248263 110305484
Peripheral swelling 63.85 12.20 25 35527 404009 110149738
Dysarthria 63.21 12.20 104 35448 84017 110469730
Arthropathy 62.57 12.20 9 35543 287513 110266234
Endophthalmitis 60.82 12.20 36 35516 8151 110545596
Tachycardia 60.42 12.20 185 35367 226460 110327287
Systemic lupus erythematosus 60.17 12.20 6 35546 254332 110299415
Corneal oedema 59.22 12.20 26 35526 3147 110550600
Rhythm idioventricular 59.07 12.20 18 35534 767 110552980
Pericarditis 58.04 12.20 3 35549 219111 110334636
Pulse absent 57.25 12.20 39 35513 11253 110542494
Cardiogenic shock 55.92 12.20 80 35472 57258 110496489
Glossodynia 55.91 12.20 4 35548 222000 110331747
Creatinine renal clearance increased 55.91 12.20 26 35526 3599 110550148
BRASH syndrome 55.24 12.20 26 35526 3697 110550050
Treatment failure 55.20 12.20 11 35541 277223 110276524
Surgery 54.79 12.20 67 35485 41216 110512531
Ventricular tachycardia 52.07 12.20 72 35480 49937 110503810
Intentional product use issue 51.14 12.20 9 35543 247897 110305850
Abdominal discomfort 50.73 12.20 32 35520 393826 110159921
Ventricular fibrillation 49.96 12.20 64 35488 41249 110512498
Sedation complication 49.29 12.20 45 35507 19810 110533937
Swelling 48.79 12.20 26 35526 351015 110202732
Rheumatoid arthritis 48.21 12.20 18 35534 299595 110254152
Renal function test abnormal 47.99 12.20 32 35520 8914 110544833
Colitis 47.53 12.20 103 35449 102220 110451527
Wound 47.30 12.20 9 35543 234428 110319319
Rebound psychosis 46.57 12.20 13 35539 405 110553342
Neuropathy peripheral 46.52 12.20 145 35407 179132 110374615
Sinus tachycardia 46.23 12.20 64 35488 44429 110509318
Anterior chamber flare 44.69 12.20 11 35541 207 110553540
Blood calcium decreased 44.09 12.20 56 35496 35789 110517958
Fibromyalgia 43.26 12.20 3 35549 170906 110382841
Hepatic enzyme increased 42.81 12.20 25 35527 320867 110232880
Arteriospasm coronary 42.77 12.20 30 35522 9070 110544677
Spinal cord injury 42.33 12.20 17 35535 1648 110552099
Rectal haemorrhage 40.90 12.20 107 35445 119726 110434021
Pulmonary oedema 40.81 12.20 96 35456 100563 110453184
Creatinine renal clearance decreased 40.21 12.20 42 35510 21773 110531974
Oral candidiasis 40.09 12.20 60 35492 44700 110509047
Synovitis 40.03 12.20 19 35533 274073 110279674
Neuromuscular block prolonged 39.74 12.20 15 35537 1232 110552515
Folliculitis 39.53 12.20 4 35548 167649 110386098
Weight increased 39.53 12.20 46 35506 419598 110134149
Haematochezia 39.27 12.20 103 35449 115421 110438326
Product use issue 39.20 12.20 26 35526 311669 110242078
Constipation 39.16 12.20 222 35330 357564 110196183
Seizure 38.57 12.20 157 35395 221028 110332719
Musculoskeletal stiffness 38.47 12.20 21 35531 279801 110273946
Lower respiratory tract infection 38.45 12.20 15 35537 243091 110310656
Sinusitis 38.34 12.20 24 35528 296664 110257083
Anaesthetic complication 38.12 12.20 20 35532 3586 110550161
Intraocular pressure increased 37.99 12.20 30 35522 10846 110542901
Shock 37.25 12.20 64 35488 53524 110500223
Anorectal disorder 37.08 12.20 18 35534 2741 110551006
Discomfort 36.08 12.20 12 35540 214695 110339052
Therapeutic product effect decreased 35.58 12.20 17 35535 244299 110309448
Duodenal ulcer perforation 35.47 12.20 7 35545 177693 110376054
Wheezing 35.31 12.20 19 35533 255211 110298536
Cholinergic syndrome 35.25 12.20 14 35538 1318 110552429
Haemodynamic instability 35.10 12.20 40 35512 22848 110530899
Choroidal detachment 34.79 12.20 12 35540 760 110552987
Toxicity to various agents 34.30 12.20 268 35284 480287 110073460
Atrioventricular block complete 34.07 12.20 37 35515 20045 110533702
Apnoea 34.03 12.20 31 35521 13608 110540139
Dermatitis acneiform 33.94 12.20 30 35522 12665 110541082
Sinus bradycardia 33.04 12.20 44 35508 29439 110524308
Hyperhidrosis 32.69 12.20 133 35419 187165 110366582
Erythema 32.65 12.20 182 35370 291265 110262482
Aplastic anaemia 31.52 12.20 39 35513 24269 110529478
Pupil fixed 31.48 12.20 18 35534 3820 110549927
Intestinal obstruction 31.17 12.20 59 35493 53168 110500579
Sedation 31.06 12.20 69 35483 69614 110484133
Disseminated intravascular coagulation 30.95 12.20 51 35501 41235 110512512
Laryngospasm 30.74 12.20 19 35533 4649 110549098
Inflammation 30.43 12.20 12 35540 193226 110360521
Post procedural complication 30.21 12.20 40 35512 26618 110527129
Asthma 29.98 12.20 22 35530 250269 110303478
Orthostatic hypotension 29.98 12.20 66 35486 66183 110487564
Blood cholesterol increased 29.89 12.20 11 35541 184774 110368973
Blood pressure decreased 29.76 12.20 93 35459 114998 110438749
Electrocardiogram QRS complex prolonged 29.41 12.20 28 35524 12993 110540754
Coma 29.34 12.20 94 35458 117775 110435972
Pain in extremity 28.75 12.20 72 35480 487046 110066701
Ileus 28.68 12.20 42 35510 30687 110523060
Bursitis 28.40 12.20 4 35548 129914 110423833
Coma scale abnormal 28.05 12.20 24 35528 9702 110544045
Irritable bowel syndrome 27.90 12.20 9 35543 164206 110389541
Musculoskeletal pain 27.79 12.20 12 35540 183011 110370736
Respiratory depression 27.38 12.20 42 35510 31959 110521788
Acute pulmonary oedema 26.56 12.20 30 35522 16966 110536781
Keratic precipitates 26.45 12.20 9 35543 547 110553200
Polydipsia 26.41 12.20 21 35531 7667 110546080
Anaphylactic shock 26.38 12.20 54 35498 51492 110502255
Liver injury 25.98 12.20 8 35544 150405 110403342
Hypoxic-ischaemic encephalopathy 25.86 12.20 22 35530 8825 110544922
Abdominal pain 25.75 12.20 265 35287 512724 110041023
Multiple drug therapy 25.64 12.20 21 35531 7993 110545754
Overdose 25.51 12.20 145 35407 233649 110320098
Circulating anticoagulant positive 25.35 12.20 5 35547 31 110553716
Hypovolaemia 25.30 12.20 33 35519 21641 110532106
Atrioventricular block second degree 25.26 12.20 21 35531 8160 110545587
Paralysis 25.18 12.20 28 35524 15572 110538175
Corneal perforation 25.13 12.20 10 35542 946 110552801
Sinus arrest 24.77 12.20 16 35536 4226 110549521
Compartment syndrome 24.38 12.20 18 35534 5892 110547855
Colitis ulcerative 24.29 12.20 67 35485 77296 110476451
Cardio-respiratory arrest 24.10 12.20 87 35465 115749 110437998
Enzyme induction 24.08 12.20 6 35546 119 110553628
Anaphylactic reaction 23.91 12.20 86 35466 114214 110439533
Joint range of motion decreased 23.89 12.20 5 35547 121827 110431920
Supraventricular tachycardia 23.70 12.20 34 35518 24388 110529359
Metabolic acidosis 23.43 12.20 78 35474 99666 110454081
Electrocardiogram ST segment elevation 23.20 12.20 21 35531 9139 110544608
Depressed level of consciousness 23.08 12.20 84 35468 112194 110441553
Rash 23.00 12.20 162 35390 820802 109732945
Ventricular extrasystoles 22.67 12.20 32 35520 22609 110531138
Impaired healing 22.65 12.20 18 35534 196699 110357048
Loss of personal independence in daily activities 22.52 12.20 10 35542 150010 110403737
Angle closure glaucoma 22.43 12.20 14 35538 3485 110550262
Drug monitoring procedure not performed 21.95 12.20 10 35542 1320 110552427
Agitation 21.92 12.20 83 35469 112968 110440779
Atrioventricular block 21.76 12.20 27 35525 16850 110536897
Muscle injury 21.75 12.20 9 35543 140798 110412949
Pruritus 21.48 12.20 105 35447 581455 109972292
Influenza 21.39 12.20 14 35538 169087 110384660
Blister 21.31 12.20 25 35527 227351 110326396
Spinal cord injury cervical 21.19 12.20 6 35546 197 110553550
Hypopyon 21.19 12.20 10 35542 1430 110552317
Frequent bowel movements 20.63 12.20 60 35492 71330 110482417
Ventricular asystole 20.63 12.20 7 35545 422 110553325
Keratitis fungal 20.47 12.20 7 35545 432 110553315
Hyphaema 20.43 12.20 9 35543 1098 110552649
Pulseless electrical activity 20.32 12.20 26 35526 16731 110537016
Product dose omission issue 20.21 12.20 46 35506 321736 110232011
Delayed recovery from anaesthesia 19.83 12.20 11 35541 2204 110551543
Hypoaesthesia 19.67 12.20 45 35507 314178 110239569
Infection 19.50 12.20 56 35496 362144 110191603
Migraine 19.40 12.20 16 35536 171636 110382111
Cataract subcapsular 19.31 12.20 9 35543 1252 110552495
Dyspepsia 19.25 12.20 116 35436 190849 110362898
Mental status changes 19.21 12.20 61 35491 76061 110477686
Gait inability 19.08 12.20 10 35542 136366 110417381
Bundle branch block left 18.88 12.20 22 35530 12866 110540881
Therapeutic response decreased 18.84 12.20 4 35548 96495 110457252
Flushing 18.76 12.20 75 35477 104661 110449086
Corneal epithelium defect 18.75 12.20 8 35544 904 110552843
Cardiac assistance device user 18.74 12.20 5 35547 131 110553616
Prescribed overdose 18.45 12.20 3 35549 87578 110466169
Injection site pain 18.41 12.20 18 35534 177904 110375843
Mucosal inflammation 18.15 12.20 70 35482 96071 110457676
Febrile neutropenia 18 12.20 168 35384 316599 110237148
Hospitalisation 17.99 12.20 92 35460 142401 110411346
Obesity 17.90 12.20 7 35545 113344 110440403
Iris adhesions 17.70 12.20 7 35545 652 110553095
Flat anterior chamber of eye 17.61 12.20 5 35547 166 110553581
Restrictive cardiomyopathy 17.58 12.20 8 35544 1053 110552694
Anterior segment ischaemia 17.56 12.20 4 35548 53 110553694
Rhabdomyolysis 17.55 12.20 81 35471 120320 110433427
Peripheral venous disease 17.45 12.20 3 35549 84114 110469633
Back pain 17.42 12.20 61 35491 370935 110182812
Gastrointestinal disorder 17.39 12.20 32 35520 241920 110311827
Nausea 17.21 12.20 519 35033 1235171 109318576
Type 2 diabetes mellitus 17.13 12.20 19 35533 177213 110376534
Night sweats 17.07 12.20 11 35541 133972 110419775
Therapeutic product effect delayed 17.05 12.20 13 35539 4466 110549281
Interstitial lung disease 17.00 12.20 12 35540 139322 110414425
Prinzmetal angina 16.91 12.20 10 35542 2259 110551488
Neuromuscular blockade 16.88 12.20 7 35545 737 110553010
Generalised tonic-clonic seizure 16.81 12.20 47 35505 54633 110499114
N-terminal prohormone brain natriuretic peptide 16.80 12.20 4 35548 65 110553682
Injection site reaction 16.77 12.20 4 35548 89066 110464681
Anterior chamber inflammation 16.60 12.20 7 35545 768 110552979
Salivary hypersecretion 16.53 12.20 24 35528 17397 110536350
Drug-induced liver injury 16.51 12.20 9 35543 120058 110433689
Large intestinal obstruction 16.34 12.20 12 35540 3896 110549851
Injection site erythema 16.28 12.20 5 35547 94171 110459576
Dizziness 16.19 12.20 145 35407 698048 109855699
Hypokalaemia 16.01 12.20 107 35445 182341 110371406
Judgement impaired 15.86 12.20 8 35544 1322 110552425
Bronchospasm 15.85 12.20 32 35520 30207 110523540
Pressure of speech 15.85 12.20 8 35544 1324 110552423
Kounis syndrome 15.83 12.20 14 35538 5911 110547836
Malnutrition 15.67 12.20 30 35522 27249 110526498
Choroidal effusion 15.67 12.20 7 35545 883 110552864
Lung disorder 15.61 12.20 21 35531 180026 110373721
Retinal occlusive vasculitis 15.60 12.20 5 35547 252 110553495
Tarsal tunnel syndrome 15.33 12.20 6 35546 543 110553204
Tendon disorder 15.27 12.20 16 35536 8321 110545426
Urticaria 15.25 12.20 52 35500 318805 110234942
Strabismus 15.21 12.20 11 35541 3488 110550259
Memory impairment 15.10 12.20 25 35527 196919 110356828
Psoriatic arthropathy 15.07 12.20 25 35527 196736 110357011
Blood pressure systolic decreased 14.97 12.20 20 35532 13421 110540326
Ill-defined disorder 14.96 12.20 17 35535 156836 110396911
Myocardial ischaemia 14.91 12.20 29 35523 26655 110527092
Muscle twitching 14.89 12.20 31 35521 29904 110523843
Scleritis 14.87 12.20 13 35539 5407 110548340
Electrocardiogram ST segment depression 14.79 12.20 13 35539 5448 110548299
Liver function test increased 14.78 12.20 5 35547 88543 110465204
Dysprosody 14.78 12.20 3 35549 22 110553725
Purpura senile 14.67 12.20 6 35546 609 110553138
C-reactive protein increased 14.64 12.20 30 35522 217889 110335858
Alopecia 14.55 12.20 64 35488 364689 110189058
Peritumoural oedema 14.55 12.20 3 35549 24 110553723
Muscle rigidity 14.52 12.20 27 35525 24004 110529743
Glaucoma 14.49 12.20 26 35526 22491 110531256
Large intestine perforation 14.47 12.20 22 35530 16607 110537140
Catatonia 14.44 12.20 18 35534 11282 110542465
Renal failure 14.32 12.20 123 35429 226451 110327296
Thrombocytopenic purpura 14.24 12.20 10 35542 3029 110550718
pH body fluid abnormal 14.11 12.20 4 35548 132 110553615
Atrioventricular block first degree 14.09 12.20 20 35532 14205 110539542
Fibrinolysis increased 14.04 12.20 3 35549 29 110553718
Seasonal affective disorder 13.99 12.20 5 35547 352 110553395
Limb mass 13.97 12.20 11 35541 3958 110549789
Pupillary reflex impaired 13.86 12.20 11 35541 4004 110549743
Myalgia 13.79 12.20 32 35520 222349 110331398
Hirsutism 13.75 12.20 8 35544 1755 110551992
Hypersensitivity 13.74 12.20 75 35477 403923 110149824
Stomatitis 13.66 12.20 43 35509 270199 110283548
Cardiomyopathy 13.61 12.20 32 35520 33493 110520254
Intestinal pseudo-obstruction 13.35 12.20 10 35542 3346 110550401
Failure to thrive 13.32 12.20 19 35533 13555 110540192
Injury 13.14 12.20 23 35529 177242 110376505
Retinal detachment 13.11 12.20 17 35535 11083 110542664
Vitritis 13.06 12.20 9 35543 2644 110551103
Visual acuity tests abnormal 13.02 12.20 4 35548 175 110553572
Electrocardiogram QRS complex shortened 13.01 12.20 6 35546 814 110552933
Drug hypersensitivity 12.99 12.20 89 35463 454001 110099746
Crohn's disease 12.67 12.20 8 35544 2030 110551717
Respiratory failure 12.63 12.20 115 35437 215217 110338530
Antipsychotic drug level decreased 12.61 12.20 7 35545 1405 110552342
Hypotony of eye 12.60 12.20 5 35547 470 110553277
Urinary retention 12.56 12.20 50 35502 69633 110484114
Vitreous opacities 12.55 12.20 6 35546 883 110552864
Prothrombin time prolonged 12.50 12.20 21 35531 17240 110536507
Adverse event 12.47 12.20 10 35542 108799 110444948
Panophthalmitis 12.36 12.20 4 35548 208 110553539
Spleen congestion 12.36 12.20 5 35547 494 110553253
Visual acuity reduced 12.30 12.20 30 35522 32143 110521604
Bacterial translocation 12.25 12.20 7 35545 1485 110552262
Vomiting 12.24 12.20 381 35171 910294 109643453
Ulcerative keratitis 12.22 12.20 11 35541 4755 110548992
Hypertension 12.20 12.20 231 35321 509853 110043894

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03BA01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
BELLADONNA AND DERIVATIVES, PLAIN
Belladonna alkaloids, tertiary amines
ATC A03CB03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS
Belladonna and derivatives in combination with psycholeptics
ATC S01FA01 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
ATC V03AB54 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
FDA MoA N0000000125 Cholinergic Muscarinic Antagonists
FDA MoA N0000175370 Cholinergic Antagonists
FDA EPC N0000175574 Anticholinergic
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D009184 Mydriatics
MeSH PA D010276 Parasympatholytics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents
FDA EPC N0000175700 Cholinergic Muscarinic Antagonist
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35523 bronchodilator agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:50247 antidote
CHEBI has role CHEBI:50370 parasympatholytic
CHEBI has role CHEBI:50513 mydriatic agent
CHEBI has role CHEBI:50514 vasoconstrictor agent
CHEBI has role CHEBI:50864 insulin-sensitizing drug
CHEBI has role CHEBI:60807 anaesthesia adjuvant
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:76916 hyperglycemic agent
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:90753 antidote to organophosphate poisoning
CHEBI has role CHEBI:136860 antidote to sarin poisoning
CHEBI has role CHEBI:146270 oneirogen
CHEBI has role CHEBI:38325 muscarinic agonist
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:49201 anti-ulcer drug

Related Drugs by ATC class:

A03BA Belladonna alkaloids, tertiary amines 1 drug
hyoscyamine
A03CB Belladonna and derivatives in combination with psycholeptics 3 drugs
hyoscyaminemethscopolaminemethylhomatropine
S01FA Anticholinergics 5 drugs
cyclopentolatehomatropinemethscopolaminescopolaminetropicamide
V03AB Antidotes 28 drugs
4-dimethylaminophenolacetylcysteineamyl nitriteandexanet alfacopper sulfatedimercaprolethanolflumazenilfomepizoleglutathionehydroxocobalaminidarucizumab show all 28 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Perioperative Mydriasis indication




🐶 Veterinary Drug Use

SpeciesUseRelation
Rodents Treatment of Syphacia obvelata (pinworm) Indication

🐶 Veterinary products

ProductApplicantIngredients
Freed No. 10, Freed No. 25 Zoetis Inc. 2
Dyrex Powder Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.24 acidic
pKa2 9.26 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST Ki 9.31 WOMBAT-PK CHEMBL
Muscarinic acetylcholine receptor M2 GPCR ANTAGONIST Ki 8.97 WOMBAT-PK CHEMBL
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Ki 9.50 WOMBAT-PK CHEMBL
Alpha-2A adrenergic receptor GPCR ANTAGONIST Ki 4.85 IUPHAR
5-hydroxytryptamine receptor 2A GPCR Ki 5.16 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 6.28 DRUG MATRIX
Histamine H1 receptor GPCR Ki 5.91 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 9.39 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 9.29 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 6.18 DRUG MATRIX
Solute carrier family 22 member 1 Transporter IC50 4.91 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 9.15 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 9.59 CHEMBL
Acetylcholinesterase Enzyme Ki 9.46 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 9.46 CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 9.92 CHEMBL
Muscarinic receptor M1 GPCR Ki 9.70 CHEMBL
Muscarinic acetylcholine receptor M5 GPCR Ki 9.07 CHEMBL
Muscarinic acetylcholine receptor GPCR Kd 8.99 CHEMBL
Muscarinic acetylcholine receptor M4 GPCR Ki 9.28 CHEMBL
Nicotinic acetylcholine receptor alpha 5 subunit Ion channel Ki 4.49 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 9.52 CHEMBL

External reference:

IDSource
4019591 VUID
N0000147687 NUI
D00113 KEGG_DRUG
5908-99-6 SECONDARY_CAS_RN
1223 RXNORM
C0004259 UMLSCUI
CHEBI:16684 CHEBI
OIN PDB_CHEM_ID
CHEMBL517712 ChEMBL_ID
CHEMBL2146146 ChEMBL_ID
DB00572 DRUGBANK_ID
D001285 MESH_DESCRIPTOR_UI
174174 PUBCHEM_CID
320 IUPHAR_LIGAND_ID
7C0697DR9I UNII
27333 MMSL
405 MMSL
4229 MMSL
d00174 MMSL
4017410 VANDF
4019591 VANDF
001715 NDDF
001717 NDDF
372832002 SNOMEDCT_US
73949004 SNOMEDCT_US
74237004 SNOMEDCT_US
7C0697DR9I INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lomotil HUMAN PRESCRIPTION DRUG LABEL 2 0025-0061 TABLET 0.03 mg ORAL NDA 23 sections
Diphenoxylate Hydrochloride and Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0054-3194 SOLUTION 0.03 mg ORAL ANDA 21 sections
Isopto Atropine HUMAN PRESCRIPTION DRUG LABEL 1 0065-0303 SOLUTION 10 mg OPHTHALMIC NDA 26 sections
atropine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0065-0817 SOLUTION 10 mg OPHTHALMIC NDA 25 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9784 INJECTION, SOLUTION 0.10 mg INTRAVENOUS ANDA 15 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9802 INJECTION, SOLUTION 0.40 mg INTRAVENOUS ANDA 15 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9802 INJECTION, SOLUTION 0.40 mg INTRAVENOUS ANDA 15 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9804 INJECTION, SOLUTION 0.40 mg INTRAVENOUS NDA 15 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9804 INJECTION, SOLUTION 0.40 mg INTRAVENOUS NDA 15 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9823 INJECTION, SOLUTION 0.05 mg INTRAMUSCULAR NDA 14 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0404-9989 INJECTION, SOLUTION 1 mg INTRAVENOUS NDA 14 sections
Diphenoxylate Hydrochloride and Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0406-1236 TABLET 0.03 mg ORAL ANDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1630 INJECTION, SOLUTION 0.10 mg INTRAVENOUS NDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1630 INJECTION, SOLUTION 0.10 mg INTRAVENOUS NDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-4910 INJECTION, SOLUTION 0.10 mg INTRAVENOUS NDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-4910 INJECTION, SOLUTION 0.10 mg INTRAVENOUS NDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-4911 INJECTION, SOLUTION 0.10 mg INTRAVENOUS NDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-4911 INJECTION, SOLUTION 0.10 mg INTRAVENOUS NDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-9630 INJECTION, SOLUTION 0.05 mg INTRAVENOUS NDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0409-9630 INJECTION, SOLUTION 0.05 mg INTRAVENOUS NDA 23 sections
Belladonna Alkaloids with Phenobartbital HUMAN PRESCRIPTION DRUG LABEL 4 0440-7183 TABLET 0.02 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0517-1001 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0517-1004 INJECTION, SOLUTION 0.40 mg INTRAVENOUS ANDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0641-6006 INJECTION 0.40 mg INTRAMUSCULAR unapproved drug other 16 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0641-6251 INJECTION 0.40 mg ENDOTRACHEAL ANDA 22 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0641-6274 INJECTION 0.40 mg INTRAVASCULAR ANDA 23 sections
Atropine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0641-6275 INJECTION 1 mg INTRAVENOUS ANDA 23 sections
ATROPEN Auto-Injector HUMAN PRESCRIPTION DRUG LABEL 1 11704-101 INJECTION 2 mg INTRAMUSCULAR NDA 26 sections
ATROPEN Auto-Injector HUMAN PRESCRIPTION DRUG LABEL 1 11704-104 INJECTION 0.50 mg INTRAMUSCULAR NDA 26 sections
ATROPEN Auto-Injector HUMAN PRESCRIPTION DRUG LABEL 1 11704-105 INJECTION 1 mg INTRAMUSCULAR NDA 26 sections