Stem definition | Drug id | CAS RN |
---|---|---|
steroids for topical use, acetal derivatives | 633 | 126544-47-6 |
Dose | Unit | Route |
---|---|---|
0.20 | mg | N |
0.16 | mg | Inhal.aerosol |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.00 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.90 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 33.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.04 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 20, 2006 | FDA | TAKEDA GMBH |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 1640.09 | 17.99 | 799 | 19808 | 90743 | 46574712 |
Wheezing | 675.39 | 17.99 | 370 | 20237 | 53016 | 46612439 |
Obstructive airways disorder | 500.27 | 17.99 | 197 | 20410 | 13215 | 46652240 |
Forced expiratory volume decreased | 331.97 | 17.99 | 113 | 20494 | 4991 | 46660464 |
Pneumonia viral | 325.29 | 17.99 | 119 | 20488 | 6505 | 46658950 |
Productive cough | 315.30 | 17.99 | 224 | 20383 | 50491 | 46614964 |
Sputum discoloured | 280.77 | 17.99 | 129 | 20478 | 12649 | 46652806 |
Dyspnoea | 260.98 | 17.99 | 647 | 19960 | 514901 | 46150554 |
Cough | 258.82 | 17.99 | 405 | 20202 | 229844 | 46435611 |
Therapeutic product effect incomplete | 228.55 | 17.99 | 223 | 20384 | 77930 | 46587525 |
Soft tissue disorder | 219.68 | 17.99 | 79 | 20528 | 4107 | 46661348 |
Blood count abnormal | 177.48 | 17.99 | 106 | 20501 | 17772 | 46647683 |
Sleep disorder due to a general medical condition | 161.21 | 17.99 | 60 | 20547 | 3439 | 46662016 |
Arthritis | 159.00 | 17.99 | 183 | 20424 | 77133 | 46588322 |
Herpes zoster | 145.21 | 17.99 | 164 | 20443 | 67708 | 46597747 |
Middle insomnia | 136.91 | 17.99 | 72 | 20535 | 9443 | 46656012 |
Breath sounds abnormal | 132.34 | 17.99 | 66 | 20541 | 7749 | 46657706 |
Chest discomfort | 128.74 | 17.99 | 178 | 20429 | 90091 | 46575364 |
Nasopharyngitis | 125.16 | 17.99 | 235 | 20372 | 153763 | 46511692 |
Blood cholesterol increased | 118.35 | 17.99 | 115 | 20492 | 39898 | 46625557 |
Fibromyalgia | 117.73 | 17.99 | 110 | 20497 | 36353 | 46629102 |
Nasal congestion | 107.55 | 17.99 | 119 | 20488 | 47994 | 46617461 |
Oral pain | 96.22 | 17.99 | 83 | 20524 | 24714 | 46640741 |
Bronchial wall thickening | 93.77 | 17.99 | 28 | 20579 | 803 | 46664652 |
Influenza | 91.56 | 17.99 | 151 | 20456 | 89119 | 46576336 |
Sleep apnoea syndrome | 79.50 | 17.99 | 71 | 20536 | 22130 | 46643325 |
Blood pressure systolic increased | 76.35 | 17.99 | 78 | 20529 | 28709 | 46636746 |
Crepitations | 76.16 | 17.99 | 42 | 20565 | 6050 | 46659405 |
Heart rate increased | 75.99 | 17.99 | 126 | 20481 | 74665 | 46590790 |
Respiratory tract congestion | 73.74 | 17.99 | 54 | 20553 | 12710 | 46652745 |
Body temperature decreased | 71.36 | 17.99 | 54 | 20553 | 13355 | 46652100 |
Liver function test abnormal | 69.71 | 17.99 | 94 | 20513 | 46393 | 46619062 |
Toxicity to various agents | 68.51 | 17.99 | 7 | 20600 | 211759 | 46453696 |
Synovitis | 67.62 | 17.99 | 107 | 20500 | 60968 | 46604487 |
Death | 67.41 | 17.99 | 32 | 20575 | 335516 | 46329939 |
Glaucoma | 67.32 | 17.99 | 56 | 20551 | 15865 | 46649590 |
Bronchiectasis | 66.83 | 17.99 | 45 | 20562 | 9271 | 46656184 |
Respiratory rate increased | 65.21 | 17.99 | 48 | 20559 | 11385 | 46654070 |
Acute kidney injury | 62.21 | 17.99 | 14 | 20593 | 235841 | 46429614 |
Peripheral swelling | 61.62 | 17.99 | 181 | 20426 | 157890 | 46507565 |
Bronchitis | 61.57 | 17.99 | 141 | 20466 | 105838 | 46559617 |
Infection | 60.95 | 17.99 | 162 | 20445 | 133430 | 46532025 |
Nasal polyps | 60.35 | 17.99 | 26 | 20581 | 2184 | 46663271 |
Diarrhoea | 56.21 | 17.99 | 101 | 20506 | 559501 | 46105954 |
Hypoventilation | 56.00 | 17.99 | 30 | 20577 | 4080 | 46661375 |
Drug interaction | 55.72 | 17.99 | 11 | 20596 | 203083 | 46462372 |
Allergy to animal | 53.53 | 17.99 | 17 | 20590 | 601 | 46664854 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 53.12 | 17.99 | 16 | 20591 | 473 | 46664982 |
Dyspnoea exertional | 50.08 | 17.99 | 84 | 20523 | 50205 | 46615250 |
Leukopenia | 48.93 | 17.99 | 99 | 20508 | 68244 | 46597211 |
Blood immunoglobulin E increased | 48.88 | 17.99 | 21 | 20586 | 1752 | 46663703 |
Secretion discharge | 48.77 | 17.99 | 37 | 20570 | 9182 | 46656273 |
Respiratory disorder | 48.42 | 17.99 | 60 | 20547 | 27240 | 46638215 |
Nausea | 47.63 | 17.99 | 151 | 20456 | 687303 | 45978152 |
Lower respiratory tract infection | 47.05 | 17.99 | 86 | 20521 | 55003 | 46610452 |
Oropharyngeal pain | 46.77 | 17.99 | 102 | 20505 | 74066 | 46591389 |
Bronchial secretion retention | 46.49 | 17.99 | 17 | 20590 | 926 | 46664529 |
Neurosensory hypoacusis | 46.38 | 17.99 | 13 | 20594 | 296 | 46665159 |
Sensitivity to weather change | 45.30 | 17.99 | 29 | 20578 | 5487 | 46659968 |
Sinusitis | 45.29 | 17.99 | 143 | 20464 | 129625 | 46535830 |
Peak expiratory flow rate decreased | 44.99 | 17.99 | 15 | 20592 | 620 | 46664835 |
Bronchial disorder | 44.95 | 17.99 | 17 | 20590 | 1018 | 46664437 |
Sputum purulent | 44.54 | 17.99 | 16 | 20591 | 828 | 46664627 |
Thrombocytopenia | 44.17 | 17.99 | 3 | 20604 | 126578 | 46538877 |
Rhinitis allergic | 43.96 | 17.99 | 31 | 20576 | 6877 | 46658578 |
Humidity intolerance | 43.59 | 17.99 | 13 | 20594 | 371 | 46665084 |
Blood test abnormal | 43.42 | 17.99 | 35 | 20572 | 9485 | 46655970 |
Rhinitis | 42.42 | 17.99 | 32 | 20575 | 7874 | 46657581 |
Nasal turbinate hypertrophy | 42.17 | 17.99 | 13 | 20594 | 416 | 46665039 |
Restrictive pulmonary disease | 42.15 | 17.99 | 17 | 20590 | 1209 | 46664246 |
Total lung capacity increased | 42.08 | 17.99 | 15 | 20592 | 759 | 46664696 |
Pulmonary function test decreased | 41.43 | 17.99 | 24 | 20583 | 3796 | 46661659 |
Bronchial haemorrhage | 40.56 | 17.99 | 12 | 20595 | 333 | 46665122 |
Tenderness | 39.85 | 17.99 | 43 | 20564 | 16838 | 46648617 |
Bronchial neoplasm | 39.78 | 17.99 | 11 | 20596 | 238 | 46665217 |
Pneumonia | 39.22 | 17.99 | 292 | 20315 | 376028 | 46289427 |
Idiopathic intracranial hypertension | 38.99 | 17.99 | 20 | 20587 | 2489 | 46662966 |
Neutropenia | 38.75 | 17.99 | 8 | 20599 | 143196 | 46522259 |
Broncholithiasis | 38.64 | 17.99 | 9 | 20598 | 94 | 46665361 |
White blood cell count decreased | 38.18 | 17.99 | 3 | 20604 | 112228 | 46553227 |
Breast neoplasm | 37.89 | 17.99 | 16 | 20591 | 1279 | 46664176 |
Kyphosis | 37.67 | 17.99 | 19 | 20588 | 2282 | 46663173 |
Loss of personal independence in daily activities | 37.60 | 17.99 | 80 | 20527 | 57103 | 46608352 |
Vomiting | 37.56 | 17.99 | 91 | 20516 | 452703 | 46212752 |
Blood pressure increased | 37.45 | 17.99 | 132 | 20475 | 126534 | 46538921 |
Respiratory tract inflammation | 37.29 | 17.99 | 12 | 20595 | 443 | 46665012 |
Hyper IgE syndrome | 36.31 | 17.99 | 10 | 20597 | 213 | 46665242 |
Rales | 34.86 | 17.99 | 31 | 20576 | 9600 | 46655855 |
Gastrooesophageal reflux disease | 34.72 | 17.99 | 91 | 20516 | 74253 | 46591202 |
Lipohypertrophy | 34.69 | 17.99 | 13 | 20594 | 759 | 46664696 |
Hypotension | 34.67 | 17.99 | 31 | 20576 | 232558 | 46432897 |
Pulmonary mass | 34.52 | 17.99 | 41 | 20566 | 17816 | 46647639 |
Off label use | 34.18 | 17.99 | 73 | 20534 | 379768 | 46285687 |
Malaise | 33.90 | 17.99 | 256 | 20351 | 330976 | 46334479 |
Limb injury | 33.77 | 17.99 | 42 | 20565 | 19132 | 46646323 |
Lymph node calcification | 33.65 | 17.99 | 9 | 20598 | 171 | 46665284 |
Bronchospasm | 33.61 | 17.99 | 38 | 20569 | 15669 | 46649786 |
Confusional state | 32.42 | 17.99 | 15 | 20592 | 159877 | 46505578 |
Mycobacterium avium complex infection | 32.40 | 17.99 | 18 | 20589 | 2630 | 46662825 |
Lower respiratory tract congestion | 32.34 | 17.99 | 16 | 20591 | 1845 | 46663610 |
Peak expiratory flow rate abnormal | 31.81 | 17.99 | 8 | 20599 | 118 | 46665337 |
Hypersensitivity | 31.77 | 17.99 | 141 | 20466 | 150180 | 46515275 |
Chronic obstructive pulmonary disease | 31.59 | 17.99 | 75 | 20532 | 57558 | 46607897 |
Bacterial disease carrier | 31.45 | 17.99 | 12 | 20595 | 736 | 46664719 |
Rheumatoid arthritis | 31.26 | 17.99 | 36 | 20571 | 240179 | 46425276 |
Febrile neutropenia | 30.90 | 17.99 | 3 | 20604 | 94624 | 46570831 |
Weight decreased | 30.67 | 17.99 | 178 | 20429 | 210671 | 46454784 |
Eosinophilia | 30.54 | 17.99 | 40 | 20567 | 19177 | 46646278 |
Viral infection | 29.42 | 17.99 | 50 | 20557 | 30185 | 46635270 |
Neuropathy peripheral | 29.37 | 17.99 | 3 | 20604 | 90890 | 46574565 |
Soft tissue swelling | 29.32 | 17.99 | 12 | 20595 | 886 | 46664569 |
Sinus pain | 29.03 | 17.99 | 15 | 20592 | 1895 | 46663560 |
Urinary tract infection | 28.67 | 17.99 | 33 | 20574 | 220233 | 46445222 |
Endometrial ablation | 28.61 | 17.99 | 11 | 20596 | 689 | 46664766 |
Increased bronchial secretion | 28.41 | 17.99 | 14 | 20593 | 1600 | 46663855 |
Platelet count decreased | 28.30 | 17.99 | 5 | 20602 | 100019 | 46565436 |
Hypokalaemia | 28.20 | 17.99 | 3 | 20604 | 88021 | 46577434 |
Upper-airway cough syndrome | 27.89 | 17.99 | 25 | 20582 | 7822 | 46657633 |
Treatment failure | 27.80 | 17.99 | 4 | 20603 | 93083 | 46572372 |
Reversible airways obstruction | 27.32 | 17.99 | 10 | 20597 | 546 | 46664909 |
Rash | 26.95 | 17.99 | 75 | 20532 | 356437 | 46309018 |
Eosinophilic granulomatosis with polyangiitis | 26.71 | 17.99 | 14 | 20593 | 1822 | 46663633 |
Emphysema | 26.70 | 17.99 | 26 | 20581 | 9028 | 46656427 |
Rhinorrhoea | 26.09 | 17.99 | 62 | 20545 | 47603 | 46617852 |
Forced vital capacity decreased | 25.85 | 17.99 | 11 | 20596 | 896 | 46664559 |
Sarcoidosis | 25.74 | 17.99 | 20 | 20587 | 5139 | 46660316 |
Hepatic enzyme increased | 25.66 | 17.99 | 3 | 20604 | 81784 | 46583671 |
Lung disorder | 25.53 | 17.99 | 58 | 20549 | 43246 | 46622209 |
Pulmonary function test abnormal | 25.11 | 17.99 | 12 | 20595 | 1283 | 46664172 |
Seasonal allergy | 24.76 | 17.99 | 30 | 20577 | 13304 | 46652151 |
Infusion related reaction | 24.73 | 17.99 | 7 | 20600 | 101201 | 46564254 |
Cardiac arrest | 24.55 | 17.99 | 5 | 20602 | 90394 | 46575061 |
Ligament pain | 24.51 | 17.99 | 7 | 20600 | 171 | 46665284 |
Sepsis | 24.28 | 17.99 | 15 | 20592 | 135999 | 46529456 |
Rhonchi | 24.24 | 17.99 | 14 | 20593 | 2201 | 46663254 |
Seizure | 24.24 | 17.99 | 12 | 20595 | 123042 | 46542413 |
Oral candidiasis | 24.08 | 17.99 | 34 | 20573 | 17498 | 46647957 |
Dehydration | 24.07 | 17.99 | 21 | 20586 | 159519 | 46505936 |
Sinus congestion | 23.54 | 17.99 | 29 | 20578 | 13080 | 46652375 |
Nasal mucosal disorder | 22.73 | 17.99 | 8 | 20599 | 390 | 46665065 |
Renal impairment | 22.67 | 17.99 | 3 | 20604 | 74369 | 46591086 |
Pancytopenia | 22.49 | 17.99 | 5 | 20602 | 85053 | 46580402 |
Respiratory symptom | 22.44 | 17.99 | 13 | 20594 | 2057 | 46663398 |
Pulmonary congestion | 22.28 | 17.99 | 30 | 20577 | 14769 | 46650686 |
Constipation | 21.67 | 17.99 | 27 | 20580 | 174070 | 46491385 |
Blood creatinine increased | 21.22 | 17.99 | 4 | 20603 | 76399 | 46589056 |
Macrocytosis | 21.15 | 17.99 | 13 | 20594 | 2290 | 46663165 |
Disease progression | 21.07 | 17.99 | 7 | 20600 | 91293 | 46574162 |
Respiratory tract infection | 20.94 | 17.99 | 43 | 20564 | 29929 | 46635526 |
Eosinophilic bronchitis | 20.86 | 17.99 | 7 | 20600 | 295 | 46665160 |
Haemoglobin decreased | 20.65 | 17.99 | 16 | 20591 | 128933 | 46536522 |
Product dose omission issue | 20.08 | 17.99 | 27 | 20580 | 168493 | 46496962 |
Aspartate aminotransferase increased | 20.07 | 17.99 | 5 | 20602 | 78695 | 46586760 |
Oropharyngeal discomfort | 19.75 | 17.99 | 14 | 20593 | 3131 | 46662324 |
Ventricular failure | 19.62 | 17.99 | 7 | 20600 | 355 | 46665100 |
Stress | 19.05 | 17.99 | 58 | 20549 | 51493 | 46613962 |
Symptom recurrence | 19.01 | 17.99 | 7 | 20600 | 389 | 46665066 |
Malignant neoplasm progression | 18.90 | 17.99 | 3 | 20604 | 64923 | 46600532 |
Presbyacusis | 18.74 | 17.99 | 13 | 20594 | 2809 | 46662646 |
Varicella zoster oesophagitis | 18.60 | 17.99 | 4 | 20603 | 28 | 46665427 |
Polycystic ovaries | 18.57 | 17.99 | 10 | 20597 | 1374 | 46664081 |
Nasal obstruction | 18.57 | 17.99 | 8 | 20599 | 672 | 46664783 |
Nocturnal dyspnoea | 18.49 | 17.99 | 9 | 20598 | 1002 | 46664453 |
Aphonia | 18.33 | 17.99 | 20 | 20587 | 7925 | 46657530 |
Hyponatraemia | 18.33 | 17.99 | 11 | 20596 | 101321 | 46564134 |
Psoriasis | 18.19 | 17.99 | 6 | 20601 | 78598 | 46586857 |
Sinus operation | 18.10 | 17.99 | 10 | 20597 | 1445 | 46664010 |
Pulmonary eosinophilia | 18.06 | 17.99 | 6 | 20601 | 245 | 46665210 |
Varicella zoster gastritis | 18.02 | 17.99 | 4 | 20603 | 33 | 46665422 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 1066.79 | 25.86 | 391 | 7775 | 35783 | 29908529 |
Wheezing | 447.09 | 25.86 | 201 | 7965 | 30737 | 29913575 |
Obstructive airways disorder | 432.95 | 25.86 | 141 | 8025 | 8918 | 29935394 |
Therapeutic product effect incomplete | 290.05 | 25.86 | 154 | 8012 | 33680 | 29910632 |
Blood count abnormal | 228.10 | 25.86 | 94 | 8072 | 11558 | 29932754 |
Pulmonary function test decreased | 213.72 | 25.86 | 69 | 8097 | 4226 | 29940086 |
Sputum discoloured | 213.62 | 25.86 | 77 | 8089 | 6591 | 29937721 |
Cough | 188.86 | 25.86 | 200 | 7966 | 125442 | 29818870 |
Forced expiratory volume decreased | 169.00 | 25.86 | 54 | 8112 | 3196 | 29941116 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 165.16 | 25.86 | 38 | 8128 | 631 | 29943681 |
Productive cough | 144.29 | 25.86 | 94 | 8072 | 29859 | 29914453 |
Nasal congestion | 143.47 | 25.86 | 79 | 8087 | 18487 | 29925825 |
Nasal obstruction | 143.35 | 25.86 | 34 | 8132 | 648 | 29943664 |
Sinus pain | 137.72 | 25.86 | 33 | 8133 | 658 | 29943654 |
Bronchiectasis | 136.85 | 25.86 | 52 | 8114 | 5152 | 29939160 |
Chest discomfort | 130.10 | 25.86 | 104 | 8062 | 45376 | 29898936 |
Dyspnoea | 108.14 | 25.86 | 262 | 7904 | 333033 | 29611279 |
Respiratory disorder | 99.43 | 25.86 | 61 | 8105 | 17433 | 29926879 |
Eosinophil count abnormal | 86.06 | 25.86 | 19 | 8147 | 259 | 29944053 |
Mycobacterium avium complex infection | 85.62 | 25.86 | 31 | 8135 | 2680 | 29941632 |
Sleep disorder due to a general medical condition | 78.16 | 25.86 | 25 | 8141 | 1482 | 29942830 |
Lung consolidation | 77.11 | 25.86 | 34 | 8132 | 4918 | 29939394 |
Vital capacity decreased | 73.82 | 25.86 | 18 | 8148 | 387 | 29943925 |
Emphysema | 72.55 | 25.86 | 40 | 8126 | 9362 | 29934950 |
Throat irritation | 70.49 | 25.86 | 38 | 8128 | 8510 | 29935802 |
Pulmonary mass | 69.80 | 25.86 | 41 | 8125 | 10821 | 29933491 |
Osteopenia | 69.43 | 25.86 | 31 | 8135 | 4617 | 29939695 |
Influenza | 68.27 | 25.86 | 71 | 8095 | 43327 | 29900985 |
Dust allergy | 68.26 | 25.86 | 17 | 8149 | 400 | 29943912 |
Bronchial hyperreactivity | 66.79 | 25.86 | 21 | 8145 | 1177 | 29943135 |
Middle insomnia | 66.02 | 25.86 | 32 | 8134 | 5741 | 29938571 |
Acute kidney injury | 62.33 | 25.86 | 3 | 8163 | 273839 | 29670473 |
Nasal polyps | 59.88 | 25.86 | 20 | 8146 | 1359 | 29942953 |
Dyspnoea exertional | 59.40 | 25.86 | 60 | 8106 | 35370 | 29908942 |
Breath sounds abnormal | 58.38 | 25.86 | 28 | 8138 | 4907 | 29939405 |
Sinusitis | 56.87 | 25.86 | 57 | 8109 | 33288 | 29911024 |
Loss of personal independence in daily activities | 54.67 | 25.86 | 46 | 8120 | 21489 | 29922823 |
Blood immunoglobulin E increased | 51.72 | 25.86 | 19 | 8147 | 1711 | 29942601 |
Sensitivity to weather change | 51.10 | 25.86 | 18 | 8148 | 1436 | 29942876 |
Nasopharyngitis | 47.87 | 25.86 | 69 | 8097 | 58780 | 29885532 |
Eosinophil count | 46.47 | 25.86 | 10 | 8156 | 120 | 29944192 |
Respiratory rate increased | 45.37 | 25.86 | 29 | 8137 | 8886 | 29935426 |
Rhinorrhoea | 43.96 | 25.86 | 40 | 8126 | 20714 | 29923598 |
Vocal cord dysfunction | 43.51 | 25.86 | 10 | 8156 | 165 | 29944147 |
Spirometry abnormal | 43.08 | 25.86 | 11 | 8155 | 287 | 29944025 |
Seasonal allergy | 41.62 | 25.86 | 22 | 8144 | 4731 | 29939581 |
Suffocation feeling | 40.47 | 25.86 | 12 | 8154 | 551 | 29943761 |
Eosinophil count increased | 39.75 | 25.86 | 25 | 8141 | 7448 | 29936864 |
Lower respiratory tract infection | 38.95 | 25.86 | 42 | 8124 | 26672 | 29917640 |
Hypoxia | 38.74 | 25.86 | 56 | 8110 | 47798 | 29896514 |
Respiratory tract congestion | 38.59 | 25.86 | 22 | 8144 | 5484 | 29938828 |
Body temperature decreased | 38.52 | 25.86 | 27 | 8139 | 9628 | 29934684 |
Mycotic allergy | 38.11 | 25.86 | 9 | 8157 | 168 | 29944144 |
Blood pressure systolic increased | 37.77 | 25.86 | 32 | 8134 | 15078 | 29929234 |
Mite allergy | 35.65 | 25.86 | 9 | 8157 | 224 | 29944088 |
Blood pressure increased | 35.07 | 25.86 | 67 | 8099 | 71861 | 29872451 |
Toxicity to various agents | 34.46 | 25.86 | 4 | 8162 | 177179 | 29767133 |
Upper-airway cough syndrome | 33.96 | 25.86 | 16 | 8150 | 2694 | 29941618 |
Pulmonary function test abnormal | 33.29 | 25.86 | 13 | 8153 | 1383 | 29942929 |
Conjunctivitis allergic | 32.45 | 25.86 | 10 | 8156 | 524 | 29943788 |
Chronic obstructive pulmonary disease | 30.30 | 25.86 | 49 | 8117 | 46077 | 29898235 |
Death | 30.05 | 25.86 | 32 | 8134 | 357251 | 29587061 |
Sputum increased | 29.71 | 25.86 | 13 | 8153 | 1844 | 29942468 |
Decreased activity | 29.57 | 25.86 | 16 | 8150 | 3605 | 29940707 |
Peak expiratory flow rate decreased | 28.95 | 25.86 | 7 | 8159 | 145 | 29944167 |
Oesophageal carcinoma | 28.55 | 25.86 | 15 | 8151 | 3186 | 29941126 |
Gastrooesophageal reflux disease | 27.94 | 25.86 | 39 | 8127 | 32216 | 29912096 |
Eosinophilic granulomatosis with polyangiitis | 27.03 | 25.86 | 11 | 8155 | 1304 | 29943008 |
Hypoventilation | 26.49 | 25.86 | 14 | 8152 | 3009 | 29941303 |
Panic reaction | 26.19 | 25.86 | 11 | 8155 | 1412 | 29942900 |
Infective exacerbation of chronic obstructive airways disease | 25.93 | 25.86 | 11 | 8155 | 1447 | 29942865 |
Hypersensitivity | 25.91 | 25.86 | 50 | 8116 | 53978 | 29890334 |
Source | Code | Description |
---|---|---|
ATC | R01AD13 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
ATC | R03BA08 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids |
MeSH PA | D018926 | Anti-Allergic Agents |
MeSH PA | D005938 | Glucocorticoids |
MeSH PA | D006728 | Hormones |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Allergic rhinitis | indication | 61582004 | |
Asthma | indication | 195967001 | DOID:2841 |
Seasonal allergic rhinitis | indication | 367498001 | |
Asthma management | indication | 406162001 | |
Severe chronic obstructive pulmonary disease | off-label use | 313299006 | |
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Inactive tuberculosis | contraindication | 11999007 | |
Epistaxis | contraindication | 12441001 | |
Disease caused by parasite | contraindication | 17322007 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Acute tuberculosis | contraindication | 25629007 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Operation on nose | contraindication | 88733004 | |
Bilateral cataracts | contraindication | 95722004 | |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Osteopenia | contraindication | 312894000 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Nasal Candidiasis | contraindication | ||
Oropharyngeal Candidiasis | contraindication | ||
Nasal Trauma | contraindication | ||
Uncontrolled Bacterial Infections | contraindication | ||
Nasal Septal Ulcers | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.78 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | Ki | 7.43 | WOMBAT-PK | CHEMBL | |||
SARS-CoV-2 | Virus | INHIBITOR | IC50 | 5.36 | SCIENTIFIC LITERATURE |
ID | Source |
---|---|
4027427 | VUID |
N0000179737 | NUI |
D01703 | KEGG_DRUG |
4027427 | VANDF |
C1174745 | UMLSCUI |
CHEBI:31397 | CHEBI |
CHEMBL2040682 | ChEMBL_ID |
DB01410 | DRUGBANK_ID |
6918155 | PUBCHEM_CID |
C120481 | MESH_SUPPLEMENTAL_RECORD_UI |
7469 | IUPHAR_LIGAND_ID |
6546 | INN_ID |
S59502J185 | UNII |
274964 | RXNORM |
132906 | MMSL |
19358 | MMSL |
89965 | MMSL |
d05465 | MMSL |
008829 | NDDF |
416739001 | SNOMEDCT_US |
417420004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5989 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5990 | AEROSOL, METERED | 160 ug | RESPIRATORY (INHALATION) | NDA | 27 sections |
Omnaris | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6020 | SPRAY | 50 ug | NULLSAL | NDA | 13 sections |
Omnaris | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-701 | SPRAY | 50 ug | NULLSAL | NDA | 27 sections |
Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-711 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
Alvesco | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-712 | AEROSOL, METERED | 160 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
Zetonna | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70515-737 | AEROSOL, METERED | 37 ug | NULLSAL | NDA | 26 sections |