Stem definition | Drug id | CAS RN |
---|---|---|
prednisone and prednisolone derivatives | 294 | 5534-09-8 |
Dose | Unit | Route |
---|---|---|
0.40 | mg | N |
0.80 | mg | Inhal.aerosol |
0.80 | mg | Inhal.powder |
1.50 | mg | Inhal.solution |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.05 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.29 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 36 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.13 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 0.50 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 12, 1976 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 510.78 | 12.62 | 402 | 23042 | 112368 | 56156255 |
Wheezing | 181.15 | 12.62 | 188 | 23256 | 74838 | 56193785 |
Rheumatoid arthritis | 119.41 | 12.62 | 11 | 23433 | 382593 | 55886030 |
Dyspnoea | 95.54 | 12.62 | 492 | 22952 | 592085 | 55676538 |
Depressed mood | 85.67 | 12.62 | 90 | 23354 | 36269 | 56232354 |
Drug ineffective | 83.38 | 12.62 | 161 | 23283 | 918828 | 55349795 |
Nightmare | 80.24 | 12.62 | 62 | 23382 | 16764 | 56251859 |
Chest discomfort | 80.22 | 12.62 | 146 | 23298 | 98711 | 56169912 |
Cough | 80.11 | 12.62 | 264 | 23180 | 259697 | 56008926 |
Lip swelling | 69.08 | 12.62 | 69 | 23375 | 26203 | 56242420 |
Swelling face | 67.48 | 12.62 | 99 | 23345 | 55970 | 56212653 |
Bronchospasm | 66.69 | 12.62 | 54 | 23390 | 15615 | 56253008 |
Swollen tongue | 59.17 | 12.62 | 68 | 23376 | 30256 | 56238367 |
Contraindicated product administered | 56.34 | 12.62 | 6 | 23438 | 186280 | 56082343 |
Arthropathy | 50.24 | 12.62 | 11 | 23433 | 200264 | 56068359 |
Treatment failure | 50.23 | 12.62 | 6 | 23438 | 170386 | 56098237 |
Infusion related reaction | 49.42 | 12.62 | 13 | 23431 | 208918 | 56059705 |
Transient ischaemic attack | 45.87 | 12.62 | 63 | 23381 | 33514 | 56235109 |
Asthmatic crisis | 44.11 | 12.62 | 19 | 23425 | 1691 | 56266932 |
Aggression | 44.03 | 12.62 | 50 | 23394 | 21956 | 56246667 |
Separation anxiety disorder | 43.19 | 12.62 | 8 | 23436 | 24 | 56268599 |
Blood electrolytes abnormal | 43.02 | 12.62 | 16 | 23428 | 970 | 56267653 |
Toxicity to various agents | 42.79 | 12.62 | 20 | 23424 | 224544 | 56044079 |
Bronchial secretion retention | 42.50 | 12.62 | 19 | 23425 | 1849 | 56266774 |
Death | 42.26 | 12.62 | 48 | 23396 | 341378 | 55927245 |
Malaise | 41.19 | 12.62 | 278 | 23166 | 367582 | 55901041 |
Bacterial disease carrier | 40.41 | 12.62 | 15 | 23429 | 904 | 56267719 |
Sputum discoloured | 40.29 | 12.62 | 39 | 23405 | 14253 | 56254370 |
Throat tightness | 36.74 | 12.62 | 46 | 23398 | 22361 | 56246262 |
Flashback | 36.16 | 12.62 | 9 | 23435 | 135 | 56268488 |
Nonspecific reaction | 36.10 | 12.62 | 17 | 23427 | 1864 | 56266759 |
Systemic lupus erythematosus | 35.93 | 12.62 | 15 | 23429 | 180063 | 56088560 |
Periorbital swelling | 35.93 | 12.62 | 18 | 23426 | 2260 | 56266363 |
Off label use | 35.70 | 12.62 | 116 | 23328 | 556064 | 55712559 |
Glossodynia | 35.07 | 12.62 | 10 | 23434 | 152448 | 56116175 |
Productive cough | 34.61 | 12.62 | 74 | 23370 | 56158 | 56212465 |
Pericarditis | 34.25 | 12.62 | 3 | 23441 | 108920 | 56159703 |
Squamous cell carcinoma of the oral cavity | 33.69 | 12.62 | 10 | 23434 | 298 | 56268325 |
Abdominal discomfort | 33.19 | 12.62 | 40 | 23404 | 277234 | 55991389 |
Middle insomnia | 32.99 | 12.62 | 31 | 23413 | 10919 | 56257704 |
Eosinophilic granulomatosis with polyangiitis | 31.67 | 12.62 | 16 | 23428 | 2045 | 56266578 |
Anaphylactic reaction | 31.11 | 12.62 | 73 | 23371 | 58922 | 56209701 |
Paraesthesia oral | 30.91 | 12.62 | 34 | 23410 | 14415 | 56254208 |
Obstructive airways disorder | 30.79 | 12.62 | 37 | 23407 | 17245 | 56251378 |
Dizziness | 30.69 | 12.62 | 264 | 23180 | 375876 | 55892747 |
Infective pulmonary exacerbation of cystic fibrosis | 30.32 | 12.62 | 26 | 23418 | 8131 | 56260492 |
Oropharyngeal pain | 30.23 | 12.62 | 90 | 23354 | 83698 | 56184925 |
Anxiety | 29.90 | 12.62 | 159 | 23285 | 193013 | 56075610 |
Breast conserving surgery | 29.68 | 12.62 | 12 | 23432 | 911 | 56267712 |
Palpitations | 29.51 | 12.62 | 100 | 23344 | 99572 | 56169051 |
Gastric mucosa erythema | 29.33 | 12.62 | 9 | 23435 | 301 | 56268322 |
Miller Fisher syndrome | 29.27 | 12.62 | 7 | 23437 | 88 | 56268535 |
Limb injury | 29.23 | 12.62 | 41 | 23403 | 22229 | 56246394 |
Angioplasty | 28.56 | 12.62 | 13 | 23431 | 1319 | 56267304 |
Bronchitis | 28.39 | 12.62 | 107 | 23337 | 112204 | 56156419 |
Sinusitis | 28.15 | 12.62 | 159 | 23285 | 197422 | 56071201 |
Drug monitoring procedure not performed | 28.14 | 12.62 | 10 | 23434 | 532 | 56268091 |
Therapeutic product effect decreased | 28.04 | 12.62 | 18 | 23426 | 169434 | 56099189 |
Superinfection | 27.93 | 12.62 | 15 | 23429 | 2173 | 56266450 |
Abdominal rigidity | 27.85 | 12.62 | 14 | 23430 | 1771 | 56266852 |
Hepatic enzyme increased | 27.29 | 12.62 | 19 | 23425 | 171365 | 56097258 |
Hiccups | 26.42 | 12.62 | 14 | 23430 | 1974 | 56266649 |
Discomfort | 26.41 | 12.62 | 13 | 23431 | 141748 | 56126875 |
Arterial spasm | 26.34 | 12.62 | 6 | 23438 | 60 | 56268563 |
Pharyngeal swelling | 26.27 | 12.62 | 20 | 23424 | 5286 | 56263337 |
Sleep disorder due to a general medical condition | 25.99 | 12.62 | 25 | 23419 | 9065 | 56259558 |
Rash macular | 25.67 | 12.62 | 37 | 23407 | 20567 | 56248056 |
Differential white blood cell count abnormal | 25.21 | 12.62 | 10 | 23434 | 722 | 56267901 |
Essential tremor | 25.19 | 12.62 | 11 | 23433 | 1012 | 56267611 |
Dysmetropsia | 25.12 | 12.62 | 6 | 23438 | 75 | 56268548 |
Drug intolerance | 25.04 | 12.62 | 45 | 23399 | 264773 | 56003850 |
Peripheral vascular disorder | 24.93 | 12.62 | 20 | 23424 | 5705 | 56262918 |
Choking | 24.33 | 12.62 | 24 | 23420 | 8973 | 56259650 |
Nail infection | 24.21 | 12.62 | 14 | 23430 | 2339 | 56266284 |
Forced expiratory volume decreased | 24.04 | 12.62 | 18 | 23426 | 4642 | 56263981 |
Eye movement disorder | 23.60 | 12.62 | 18 | 23426 | 4771 | 56263852 |
Genital pain | 23.50 | 12.62 | 8 | 23436 | 374 | 56268249 |
Dermatitis allergic | 23.40 | 12.62 | 29 | 23415 | 13949 | 56254674 |
Alopecia | 23.40 | 12.62 | 55 | 23389 | 293403 | 55975220 |
Hyponatraemia | 23.13 | 12.62 | 94 | 23350 | 102045 | 56166578 |
Musculoskeletal stiffness | 22.66 | 12.62 | 19 | 23425 | 155988 | 56112635 |
Idiopathic orbital inflammation | 22.30 | 12.62 | 6 | 23438 | 124 | 56268499 |
Pregnancy with implant contraceptive | 22.03 | 12.62 | 13 | 23431 | 2255 | 56266368 |
Myalgia | 22.03 | 12.62 | 111 | 23333 | 131914 | 56136709 |
Vascular device infection | 21.15 | 12.62 | 18 | 23426 | 5572 | 56263051 |
Helicobacter infection | 20.57 | 12.62 | 3 | 23441 | 73265 | 56195358 |
Lacrimation increased | 20.07 | 12.62 | 31 | 23413 | 18317 | 56250306 |
Status asthmaticus | 19.90 | 12.62 | 9 | 23435 | 900 | 56267723 |
Gingival swelling | 19.62 | 12.62 | 15 | 23429 | 3991 | 56264632 |
Joint swelling | 19.55 | 12.62 | 59 | 23385 | 289741 | 55978882 |
Facial pain | 19.48 | 12.62 | 20 | 23424 | 7838 | 56260785 |
Secretion discharge | 19.48 | 12.62 | 23 | 23421 | 10523 | 56258100 |
Gastroenteritis aeromonas | 19.22 | 12.62 | 4 | 23440 | 25 | 56268598 |
Anger | 19.19 | 12.62 | 24 | 23420 | 11648 | 56256975 |
Poor peripheral circulation | 19.07 | 12.62 | 14 | 23430 | 3503 | 56265120 |
Duodenal ulcer perforation | 18.73 | 12.62 | 3 | 23441 | 68339 | 56200284 |
Illness | 18.51 | 12.62 | 43 | 23401 | 34468 | 56234155 |
Pain | 18.48 | 12.62 | 182 | 23262 | 663002 | 55605621 |
Urticaria | 18.37 | 12.62 | 113 | 23331 | 144563 | 56124060 |
Oral mucosal blistering | 18.35 | 12.62 | 16 | 23428 | 5118 | 56263505 |
Butterfly rash | 18.32 | 12.62 | 10 | 23434 | 1496 | 56267127 |
Tongue pruritus | 18.04 | 12.62 | 7 | 23437 | 477 | 56268146 |
Sinus operation | 17.98 | 12.62 | 11 | 23433 | 2037 | 56266586 |
Genital ulceration | 17.81 | 12.62 | 7 | 23437 | 493 | 56268130 |
Rhinovirus infection | 17.71 | 12.62 | 14 | 23430 | 3908 | 56264715 |
Hyperkinesia | 17.53 | 12.62 | 10 | 23434 | 1629 | 56266994 |
Brain contusion | 17.08 | 12.62 | 7 | 23437 | 550 | 56268073 |
Nasal discomfort | 17.07 | 12.62 | 14 | 23430 | 4118 | 56264505 |
Respiration abnormal | 17.05 | 12.62 | 16 | 23428 | 5625 | 56262998 |
Migraine | 16.66 | 12.62 | 76 | 23368 | 86721 | 56181902 |
Malignant neoplasm progression | 16.60 | 12.62 | 5 | 23439 | 73582 | 56195041 |
Drug abuse | 16.36 | 12.62 | 4 | 23440 | 67606 | 56201017 |
Angioedema | 16.36 | 12.62 | 46 | 23398 | 41407 | 56227216 |
Tendonitis | 16.29 | 12.62 | 28 | 23416 | 18069 | 56250554 |
Vaginal discharge | 15.85 | 12.62 | 16 | 23428 | 6147 | 56262476 |
Antipsychotic drug level increased | 15.57 | 12.62 | 12 | 23432 | 3230 | 56265393 |
Derealisation | 15.47 | 12.62 | 8 | 23436 | 1073 | 56267550 |
Acute myocardial infarction | 15.36 | 12.62 | 37 | 23407 | 30356 | 56238267 |
Oral mucosa erosion | 15.34 | 12.62 | 8 | 23436 | 1092 | 56267531 |
Bladder irritation | 15.13 | 12.62 | 5 | 23439 | 213 | 56268410 |
Urinary incontinence | 14.93 | 12.62 | 36 | 23408 | 29549 | 56239074 |
Stomatitis | 14.89 | 12.62 | 17 | 23427 | 120793 | 56147830 |
Pulmonary oedema | 14.85 | 12.62 | 51 | 23393 | 51092 | 56217531 |
Maternal exposure during pregnancy | 14.72 | 12.62 | 36 | 23408 | 189517 | 56079106 |
Reperfusion arrhythmia | 14.68 | 12.62 | 5 | 23439 | 234 | 56268389 |
Pneumonia streptococcal | 14.65 | 12.62 | 9 | 23435 | 1679 | 56266944 |
Skin exfoliation | 14.62 | 12.62 | 41 | 23403 | 36859 | 56231764 |
Pulmonary congestion | 14.60 | 12.62 | 25 | 23419 | 16090 | 56252533 |
Blood cholesterol increased | 14.54 | 12.62 | 6 | 23438 | 72573 | 56196050 |
Cytomegalovirus enteritis | 14.52 | 12.62 | 5 | 23439 | 242 | 56268381 |
Necrosis ischaemic | 14.49 | 12.62 | 7 | 23437 | 812 | 56267811 |
Crepitations | 14.19 | 12.62 | 16 | 23428 | 6968 | 56261655 |
Product dosage form issue | 13.77 | 12.62 | 3 | 23441 | 24 | 56268599 |
Impaired healing | 13.33 | 12.62 | 10 | 23434 | 86831 | 56181792 |
Impaired quality of life | 13.26 | 12.62 | 17 | 23427 | 8457 | 56260166 |
Mobility decreased | 13.24 | 12.62 | 13 | 23431 | 98978 | 56169645 |
Anaemia | 13.13 | 12.62 | 62 | 23382 | 267449 | 56001174 |
Platelet count decreased | 13.08 | 12.62 | 15 | 23429 | 106368 | 56162255 |
Skin fragility | 12.91 | 12.62 | 6 | 23438 | 639 | 56267984 |
Febrile neutropenia | 12.85 | 12.62 | 15 | 23429 | 105530 | 56163093 |
Abnormal behaviour | 12.84 | 12.62 | 27 | 23417 | 20245 | 56248378 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 351.87 | 13.37 | 222 | 13393 | 42389 | 31641340 |
Wheezing | 135.66 | 13.37 | 117 | 13498 | 35869 | 31647860 |
Dyspnoea | 84.44 | 13.37 | 330 | 13285 | 343149 | 31340580 |
Sleep terror | 75.30 | 13.37 | 23 | 13592 | 734 | 31682995 |
Lip swelling | 64.17 | 13.37 | 50 | 13565 | 13273 | 31670456 |
Anger | 62.91 | 13.37 | 46 | 13569 | 11107 | 31672622 |
Ballismus | 60.61 | 13.37 | 12 | 13603 | 54 | 31683675 |
Nightmare | 55.12 | 13.37 | 44 | 13571 | 12093 | 31671636 |
Swollen tongue | 50.81 | 13.37 | 43 | 13572 | 12819 | 31670910 |
Blood immunoglobulin E increased | 47.92 | 13.37 | 22 | 13593 | 2209 | 31681520 |
Lower respiratory tract infection | 43.41 | 13.37 | 57 | 13558 | 28180 | 31655549 |
Pharyngeal oedema | 42.28 | 13.37 | 28 | 13587 | 5768 | 31677961 |
Abnormal behaviour | 41.20 | 13.37 | 51 | 13564 | 23777 | 31659952 |
Infective pulmonary exacerbation of cystic fibrosis | 39.43 | 13.37 | 28 | 13587 | 6456 | 31677273 |
Malaise | 37.21 | 13.37 | 157 | 13458 | 168354 | 31515375 |
Attention-seeking behaviour | 33.96 | 13.37 | 7 | 13608 | 40 | 31683689 |
Nasal disorder | 33.82 | 13.37 | 16 | 13599 | 1719 | 31682010 |
Acquired macroglossia | 32.21 | 13.37 | 6 | 13609 | 18 | 31683711 |
Anosmia | 30.86 | 13.37 | 16 | 13599 | 2092 | 31681637 |
Chorea | 28.39 | 13.37 | 12 | 13603 | 988 | 31682741 |
Neuropsychiatric symptoms | 28.17 | 13.37 | 10 | 13605 | 514 | 31683215 |
Chest discomfort | 27.97 | 13.37 | 64 | 13551 | 49305 | 31634424 |
Cough | 27.73 | 13.37 | 123 | 13492 | 134691 | 31549038 |
Chronic obstructive pulmonary disease | 26.08 | 13.37 | 59 | 13556 | 45107 | 31638622 |
Crepitations | 25.96 | 13.37 | 16 | 13599 | 2912 | 31680817 |
Toxicity to various agents | 25.79 | 13.37 | 24 | 13591 | 181463 | 31502266 |
Dyspnoea at rest | 25.61 | 13.37 | 17 | 13598 | 3514 | 31680215 |
Sputum discoloured | 25.42 | 13.37 | 22 | 13593 | 6754 | 31676975 |
Neonatal hyponatraemia | 25.09 | 13.37 | 6 | 13609 | 73 | 31683656 |
Death | 25.00 | 13.37 | 76 | 13539 | 360493 | 31323236 |
Central obesity | 24.82 | 13.37 | 9 | 13606 | 492 | 31683237 |
Daydreaming | 24.54 | 13.37 | 9 | 13606 | 508 | 31683221 |
Nasal discomfort | 23.44 | 13.37 | 12 | 13603 | 1528 | 31682201 |
Gastrointestinal tract irritation | 22.72 | 13.37 | 7 | 13608 | 230 | 31683499 |
Crying | 22.69 | 13.37 | 19 | 13596 | 5578 | 31678151 |
Paraesthesia oral | 22.52 | 13.37 | 16 | 13599 | 3692 | 31680037 |
Gastric ulcer perforation | 22.01 | 13.37 | 10 | 13605 | 980 | 31682749 |
Productive cough | 21.85 | 13.37 | 46 | 13569 | 33494 | 31650235 |
Depressed mood | 21.79 | 13.37 | 32 | 13583 | 17543 | 31666186 |
Neuropsychiatric syndrome | 20.97 | 13.37 | 5 | 13610 | 60 | 31683669 |
Spleen congestion | 20.89 | 13.37 | 7 | 13608 | 302 | 31683427 |
Cervicogenic headache | 20.79 | 13.37 | 4 | 13611 | 15 | 31683714 |
Completed suicide | 20.27 | 13.37 | 7 | 13608 | 91507 | 31592222 |
Micturition urgency | 20.20 | 13.37 | 18 | 13597 | 5742 | 31677987 |
Malignant neoplasm progression | 19.39 | 13.37 | 5 | 13610 | 78993 | 31604736 |
Bronchomalacia | 19.19 | 13.37 | 5 | 13610 | 88 | 31683641 |
Sinusitis | 19.06 | 13.37 | 46 | 13569 | 36650 | 31647079 |
Platelet count decreased | 18.99 | 13.37 | 12 | 13603 | 110423 | 31573306 |
Mesothelioma | 18.71 | 13.37 | 7 | 13608 | 418 | 31683311 |
Palpitations | 18.67 | 13.37 | 44 | 13571 | 34539 | 31649190 |
Mood swings | 18.11 | 13.37 | 19 | 13596 | 7405 | 31676324 |
Eye swelling | 18.09 | 13.37 | 21 | 13594 | 9155 | 31674574 |
Locked-in syndrome | 17.93 | 13.37 | 6 | 13609 | 258 | 31683471 |
Self-injurious ideation | 17.54 | 13.37 | 10 | 13605 | 1577 | 31682152 |
Nasal septum perforation | 17.53 | 13.37 | 5 | 13610 | 125 | 31683604 |
Convulsive threshold lowered | 17.41 | 13.37 | 7 | 13608 | 508 | 31683221 |
Suicidal ideation | 17.19 | 13.37 | 44 | 13571 | 36362 | 31647367 |
Multifocal motor neuropathy | 16.85 | 13.37 | 4 | 13611 | 47 | 31683682 |
Graft versus host disease in gastrointestinal tract | 16.62 | 13.37 | 13 | 13602 | 3466 | 31680263 |
Off label use | 16.51 | 13.37 | 85 | 13530 | 347189 | 31336540 |
Benign prostatic hyperplasia | 16.42 | 13.37 | 24 | 13591 | 13101 | 31670628 |
Angioedema | 16.25 | 13.37 | 41 | 13574 | 33577 | 31650152 |
Apnoeic attack | 16.24 | 13.37 | 6 | 13609 | 346 | 31683383 |
Rash papular | 16.20 | 13.37 | 19 | 13596 | 8373 | 31675356 |
Ocular discomfort | 15.96 | 13.37 | 10 | 13605 | 1873 | 31681856 |
Aortic dissection | 15.58 | 13.37 | 11 | 13604 | 2511 | 31681218 |
Cystic fibrosis | 15.56 | 13.37 | 10 | 13605 | 1956 | 31681773 |
Urticaria | 15.40 | 13.37 | 57 | 13558 | 57460 | 31626269 |
Renal aplasia | 15.32 | 13.37 | 7 | 13608 | 695 | 31683034 |
Antibody test abnormal | 15.26 | 13.37 | 5 | 13610 | 201 | 31683528 |
Tryptase increased | 15.07 | 13.37 | 5 | 13610 | 209 | 31683520 |
Headache | 14.95 | 13.37 | 132 | 13483 | 183520 | 31500209 |
Thrombocytopenia | 14.86 | 13.37 | 24 | 13591 | 142723 | 31541006 |
Sleep disorder | 14.74 | 13.37 | 34 | 13581 | 26314 | 31657415 |
Ejaculation failure | 14.69 | 13.37 | 7 | 13608 | 764 | 31682965 |
Ageusia | 14.58 | 13.37 | 19 | 13596 | 9312 | 31674417 |
Renal failure | 14.54 | 13.37 | 19 | 13596 | 123311 | 31560418 |
Nasal inflammation | 14.49 | 13.37 | 5 | 13610 | 236 | 31683493 |
Weaning failure | 14.49 | 13.37 | 5 | 13610 | 236 | 31683493 |
Sleep talking | 14.44 | 13.37 | 6 | 13609 | 473 | 31683256 |
Neonatal seizure | 14.38 | 13.37 | 6 | 13609 | 478 | 31683251 |
Product administered to patient of inappropriate age | 14.36 | 13.37 | 11 | 13604 | 2846 | 31680883 |
Anaphylactic reaction | 14.24 | 13.37 | 36 | 13579 | 29517 | 31654212 |
Obstructive airways disorder | 14.19 | 13.37 | 22 | 13593 | 12642 | 31671087 |
Abdominal symptom | 14.12 | 13.37 | 6 | 13609 | 501 | 31683228 |
Eosinophilia | 14.12 | 13.37 | 31 | 13584 | 23222 | 31660507 |
Insomnia | 14.12 | 13.37 | 79 | 13536 | 94757 | 31588972 |
Hepatic cancer | 14.01 | 13.37 | 17 | 13598 | 7758 | 31675971 |
Reading disorder | 13.96 | 13.37 | 6 | 13609 | 515 | 31683214 |
Violence-related symptom | 13.95 | 13.37 | 6 | 13609 | 516 | 31683213 |
Oral pain | 13.91 | 13.37 | 19 | 13596 | 9746 | 31673983 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 681.77 | 11.65 | 506 | 31319 | 120287 | 70776332 |
Wheezing | 266.43 | 11.65 | 266 | 31559 | 93904 | 70802715 |
Dyspnoea | 148.99 | 11.65 | 710 | 31115 | 769350 | 70127269 |
Nightmare | 145.56 | 11.65 | 102 | 31723 | 22054 | 70874565 |
Lip swelling | 132.55 | 11.65 | 115 | 31710 | 33939 | 70862680 |
Depressed mood | 113.27 | 11.65 | 118 | 31707 | 43702 | 70852917 |
Swollen tongue | 108.99 | 11.65 | 107 | 31718 | 36939 | 70859680 |
Rheumatoid arthritis | 92.91 | 11.65 | 11 | 31814 | 291794 | 70604825 |
Chest discomfort | 85.66 | 11.65 | 179 | 31646 | 124202 | 70772417 |
Sleep terror | 82.85 | 11.65 | 28 | 31797 | 1187 | 70895432 |
Completed suicide | 79.06 | 11.65 | 6 | 31819 | 227129 | 70669490 |
Drug ineffective | 75.55 | 11.65 | 197 | 31628 | 939555 | 69957064 |
Anger | 74.18 | 11.65 | 60 | 31765 | 16072 | 70880547 |
Swelling face | 73.13 | 11.65 | 114 | 31711 | 63050 | 70833569 |
Malaise | 71.83 | 11.65 | 383 | 31442 | 432549 | 70464070 |
Toxicity to various agents | 69.26 | 11.65 | 43 | 31782 | 382129 | 70514490 |
Cough | 65.36 | 11.65 | 304 | 31521 | 325073 | 70571546 |
Infective pulmonary exacerbation of cystic fibrosis | 64.05 | 11.65 | 49 | 31776 | 12109 | 70884510 |
Sputum discoloured | 62.16 | 11.65 | 58 | 31767 | 18793 | 70877826 |
Death | 59.01 | 11.65 | 86 | 31739 | 509975 | 70386644 |
Bronchospasm | 58.21 | 11.65 | 61 | 31764 | 22731 | 70873888 |
Abnormal behaviour | 55.40 | 11.65 | 73 | 31752 | 34636 | 70861983 |
Infusion related reaction | 48.88 | 11.65 | 14 | 31811 | 197520 | 70699099 |
Dizziness | 48.46 | 11.65 | 365 | 31460 | 463776 | 70432843 |
Drug abuse | 48.23 | 11.65 | 5 | 31820 | 147251 | 70749368 |
Paraesthesia oral | 48.09 | 11.65 | 46 | 31779 | 15371 | 70881248 |
Separation anxiety disorder | 47.92 | 11.65 | 9 | 31816 | 27 | 70896592 |
Palpitations | 46.75 | 11.65 | 132 | 31693 | 110621 | 70785998 |
Ballismus | 46.49 | 11.65 | 12 | 31813 | 194 | 70896425 |
Off label use | 46.00 | 11.65 | 175 | 31650 | 742885 | 70153734 |
Pharyngeal oedema | 45.53 | 11.65 | 45 | 31780 | 15651 | 70880968 |
Treatment failure | 44.46 | 11.65 | 6 | 31819 | 144136 | 70752483 |
Productive cough | 44.04 | 11.65 | 104 | 31721 | 78233 | 70818386 |
Synovitis | 43.33 | 11.65 | 4 | 31821 | 129224 | 70767395 |
Transient ischaemic attack | 42.52 | 11.65 | 75 | 31750 | 45869 | 70850750 |
Asthmatic crisis | 40.99 | 11.65 | 19 | 31806 | 1865 | 70894754 |
Contraindicated product administered | 40.59 | 11.65 | 6 | 31819 | 134606 | 70762013 |
Bacterial disease carrier | 40.31 | 11.65 | 16 | 31809 | 1073 | 70895546 |
Crepitations | 39.19 | 11.65 | 32 | 31793 | 8682 | 70887937 |
Aggression | 38.43 | 11.65 | 74 | 31751 | 48372 | 70848247 |
Arthropathy | 38.31 | 11.65 | 10 | 31815 | 150047 | 70746572 |
Periorbital swelling | 37.94 | 11.65 | 19 | 31806 | 2211 | 70894408 |
Obstructive airways disorder | 37.23 | 11.65 | 52 | 31773 | 26061 | 70870558 |
Malignant neoplasm progression | 35.41 | 11.65 | 6 | 31819 | 121733 | 70774886 |
Myalgia | 34.47 | 11.65 | 158 | 31667 | 167734 | 70728885 |
Eosinophilic granulomatosis with polyangiitis | 34.05 | 11.65 | 20 | 31805 | 3193 | 70893426 |
Anxiety | 33.78 | 11.65 | 191 | 31634 | 220139 | 70676480 |
Essential tremor | 32.75 | 11.65 | 15 | 31810 | 1432 | 70895187 |
Bronchial secretion retention | 32.59 | 11.65 | 19 | 31806 | 2991 | 70893628 |
Breast conserving surgery | 32.51 | 11.65 | 12 | 31813 | 660 | 70895959 |
Blood electrolytes abnormal | 32.47 | 11.65 | 16 | 31809 | 1798 | 70894821 |
Oropharyngeal pain | 32.39 | 11.65 | 106 | 31719 | 96204 | 70800415 |
Attention-seeking behaviour | 32.33 | 11.65 | 8 | 31817 | 108 | 70896511 |
Pharyngeal swelling | 31.80 | 11.65 | 25 | 31800 | 6428 | 70890191 |
Throat tightness | 31.54 | 11.65 | 47 | 31778 | 24975 | 70871644 |
Blood immunoglobulin E increased | 31.52 | 11.65 | 22 | 31803 | 4722 | 70891897 |
Middle insomnia | 31.31 | 11.65 | 35 | 31790 | 14018 | 70882601 |
Rash macular | 30.81 | 11.65 | 47 | 31778 | 25497 | 70871122 |
Choking | 30.77 | 11.65 | 31 | 31794 | 11029 | 70885590 |
Angioedema | 30.69 | 11.65 | 82 | 31743 | 66528 | 70830091 |
Nonspecific reaction | 30.22 | 11.65 | 16 | 31809 | 2089 | 70894530 |
Crying | 29.90 | 11.65 | 42 | 31783 | 21157 | 70875462 |
Hepatic enzyme increased | 29.32 | 11.65 | 17 | 31808 | 156973 | 70739646 |
Forced expiratory volume decreased | 29.05 | 11.65 | 25 | 31800 | 7289 | 70889330 |
Anosmia | 28.66 | 11.65 | 21 | 31804 | 4862 | 70891757 |
Dermatitis allergic | 28.47 | 11.65 | 36 | 31789 | 16395 | 70880224 |
Anaphylactic reaction | 28.41 | 11.65 | 86 | 31739 | 74888 | 70821731 |
Squamous cell carcinoma of the oral cavity | 28.16 | 11.65 | 10 | 31815 | 492 | 70896127 |
Urticaria | 28.13 | 11.65 | 146 | 31679 | 162903 | 70733716 |
Gingival swelling | 27.09 | 11.65 | 19 | 31806 | 4110 | 70892509 |
Thrombocytopenia | 26.92 | 11.65 | 41 | 31784 | 239069 | 70657550 |
Angioplasty | 26.75 | 11.65 | 14 | 31811 | 1786 | 70894833 |
Antipsychotic drug level increased | 26.64 | 11.65 | 21 | 31804 | 5419 | 70891200 |
Limb injury | 26.40 | 11.65 | 44 | 31781 | 25708 | 70870911 |
Pregnancy with implant contraceptive | 25.30 | 11.65 | 13 | 31812 | 1596 | 70895023 |
Platelet count decreased | 24.80 | 11.65 | 26 | 31799 | 178196 | 70718423 |
Nail infection | 24.17 | 11.65 | 14 | 31811 | 2177 | 70894442 |
Disturbance in attention | 24.16 | 11.65 | 57 | 31768 | 42837 | 70853782 |
Dysmetropsia | 23.98 | 11.65 | 6 | 31819 | 85 | 70896534 |
Miller Fisher syndrome | 23.76 | 11.65 | 7 | 31818 | 188 | 70896431 |
Pain | 23.74 | 11.65 | 175 | 31650 | 628641 | 70267978 |
Micturition urgency | 23.21 | 11.65 | 27 | 31798 | 11287 | 70885332 |
Pericarditis | 22.88 | 11.65 | 5 | 31820 | 84700 | 70811919 |
Poor peripheral circulation | 22.78 | 11.65 | 16 | 31809 | 3469 | 70893150 |
Sinus operation | 22.73 | 11.65 | 13 | 31812 | 1974 | 70894645 |
Drug monitoring procedure not performed | 22.54 | 11.65 | 10 | 31815 | 886 | 70895733 |
Bleeding time prolonged | 22.49 | 11.65 | 11 | 31814 | 1217 | 70895402 |
Peripheral vascular disorder | 22.35 | 11.65 | 22 | 31803 | 7610 | 70889009 |
Hallucination | 22.19 | 11.65 | 80 | 31745 | 76180 | 70820439 |
Febrile neutropenia | 22.07 | 11.65 | 36 | 31789 | 204282 | 70692337 |
Anaemia | 21.78 | 11.65 | 100 | 31725 | 403323 | 70493296 |
Flashback | 21.42 | 11.65 | 7 | 31818 | 267 | 70896352 |
Abdominal rigidity | 21.38 | 11.65 | 14 | 31811 | 2707 | 70893912 |
Nasal disorder | 21.16 | 11.65 | 15 | 31810 | 3299 | 70893320 |
Idiopathic orbital inflammation | 21.05 | 11.65 | 6 | 31819 | 143 | 70896476 |
Neuropsychiatric symptoms | 20.97 | 11.65 | 10 | 31815 | 1046 | 70895573 |
Somnambulism | 20.93 | 11.65 | 18 | 31807 | 5242 | 70891377 |
Genital pain | 20.91 | 11.65 | 8 | 31817 | 486 | 70896133 |
Irritability | 20.67 | 11.65 | 50 | 31775 | 38175 | 70858444 |
Disease progression | 20.54 | 11.65 | 24 | 31801 | 156648 | 70739971 |
Migraine | 20.36 | 11.65 | 75 | 31750 | 72163 | 70824456 |
Arterial spasm | 20.27 | 11.65 | 6 | 31819 | 164 | 70896455 |
Suicidal ideation | 20.24 | 11.65 | 73 | 31752 | 69523 | 70827096 |
Hyponatraemia | 20.21 | 11.65 | 132 | 31693 | 159955 | 70736664 |
Daydreaming | 19.87 | 11.65 | 9 | 31816 | 837 | 70895782 |
Headache | 19.85 | 11.65 | 368 | 31457 | 580037 | 70316582 |
Sleep disorder due to a general medical condition | 19.84 | 11.65 | 24 | 31801 | 10452 | 70886167 |
Mood swings | 19.77 | 11.65 | 32 | 31793 | 18254 | 70878365 |
Chorea | 19.59 | 11.65 | 12 | 31813 | 2066 | 70894553 |
Ejaculation failure | 19.51 | 11.65 | 7 | 31818 | 355 | 70896264 |
Acquired macroglossia | 18.93 | 11.65 | 6 | 31819 | 207 | 70896412 |
Gastroenteritis aeromonas | 18.93 | 11.65 | 4 | 31821 | 25 | 70896594 |
Muscle spasms | 18.83 | 11.65 | 126 | 31699 | 153920 | 70742699 |
Cervicogenic headache | 18.79 | 11.65 | 4 | 31821 | 26 | 70896593 |
Liver function test abnormal | 18.52 | 11.65 | 65 | 31760 | 61081 | 70835538 |
Product administered to patient of inappropriate age | 18.12 | 11.65 | 16 | 31809 | 4827 | 70891792 |
Spleen congestion | 18.10 | 11.65 | 7 | 31818 | 438 | 70896181 |
Differential white blood cell count abnormal | 18.05 | 11.65 | 11 | 31814 | 1877 | 70894742 |
Superinfection | 17.98 | 11.65 | 15 | 31810 | 4191 | 70892428 |
Impaired quality of life | 17.83 | 11.65 | 21 | 31804 | 8895 | 70887724 |
Skin exfoliation | 17.69 | 11.65 | 55 | 31770 | 48571 | 70848048 |
Systemic lupus erythematosus | 17.69 | 11.65 | 12 | 31813 | 101890 | 70794729 |
Illness | 17.63 | 11.65 | 42 | 31783 | 31749 | 70864870 |
Neuropsychiatric syndrome | 17.55 | 11.65 | 5 | 31820 | 119 | 70896500 |
Drug intolerance | 17.48 | 11.65 | 48 | 31777 | 225639 | 70670980 |
Eye movement disorder | 17.38 | 11.65 | 19 | 31806 | 7421 | 70889198 |
Secretion discharge | 17.32 | 11.65 | 25 | 31800 | 12908 | 70883711 |
Renal failure | 17.17 | 11.65 | 37 | 31788 | 189033 | 70707586 |
Upper gastrointestinal haemorrhage | 17.12 | 11.65 | 46 | 31779 | 37431 | 70859188 |
Tongue pruritus | 17.11 | 11.65 | 7 | 31818 | 508 | 70896111 |
Nasal discharge discolouration | 17.07 | 11.65 | 11 | 31814 | 2070 | 70894549 |
Pulmonary congestion | 17.05 | 11.65 | 36 | 31789 | 25118 | 70871501 |
Central obesity | 17.04 | 11.65 | 10 | 31815 | 1593 | 70895026 |
Vaginal discharge | 16.98 | 11.65 | 15 | 31810 | 4528 | 70892091 |
Musculoskeletal stiffness | 16.94 | 11.65 | 25 | 31800 | 147735 | 70748884 |
Psychomotor hyperactivity | 16.67 | 11.65 | 27 | 31798 | 15406 | 70881213 |
Gastrointestinal tract irritation | 16.54 | 11.65 | 7 | 31818 | 553 | 70896066 |
Oral mucosal blistering | 16.24 | 11.65 | 16 | 31809 | 5540 | 70891079 |
Infection | 16.19 | 11.65 | 45 | 31780 | 210740 | 70685879 |
Joint swelling | 16 | 11.65 | 59 | 31766 | 253152 | 70643467 |
Encephalopathy | 15.94 | 11.65 | 4 | 31821 | 61657 | 70834962 |
Syncope | 15.93 | 11.65 | 128 | 31697 | 165581 | 70731038 |
Chronic obstructive pulmonary disease | 15.86 | 11.65 | 73 | 31752 | 77568 | 70819051 |
Multifocal motor neuropathy | 15.59 | 11.65 | 4 | 31821 | 63 | 70896556 |
Overdose | 15.59 | 11.65 | 33 | 31792 | 169712 | 70726907 |
Butterfly rash | 15.41 | 11.65 | 9 | 31816 | 1421 | 70895198 |
Rhinovirus infection | 15.39 | 11.65 | 17 | 31808 | 6716 | 70889903 |
Tendonitis | 15.39 | 11.65 | 32 | 31793 | 22090 | 70874529 |
Lactic acidosis | 15.37 | 11.65 | 5 | 31820 | 65019 | 70831600 |
Status asthmaticus | 15.34 | 11.65 | 8 | 31817 | 1013 | 70895606 |
Graft versus host disease in gastrointestinal tract | 15.34 | 11.65 | 16 | 31809 | 5928 | 70890691 |
Glossodynia | 15.26 | 11.65 | 10 | 31815 | 86477 | 70810142 |
Benign prostatic hyperplasia | 15.19 | 11.65 | 21 | 31804 | 10422 | 70886197 |
Nasal congestion | 15.13 | 11.65 | 64 | 31761 | 65608 | 70831011 |
Eye swelling | 15.09 | 11.65 | 33 | 31792 | 23581 | 70873038 |
Genital ulceration | 15.05 | 11.65 | 7 | 31818 | 692 | 70895927 |
Plasma cell myeloma | 15.03 | 11.65 | 7 | 31818 | 73194 | 70823425 |
Blood pressure fluctuation | 14.93 | 11.65 | 4 | 31821 | 59008 | 70837611 |
Urinary incontinence | 14.89 | 11.65 | 44 | 31781 | 37798 | 70858821 |
Ageusia | 14.71 | 11.65 | 25 | 31800 | 14837 | 70881782 |
Therapeutic product effect decreased | 14.70 | 11.65 | 26 | 31799 | 142992 | 70753627 |
Bronchomalacia | 14.68 | 11.65 | 5 | 31820 | 217 | 70896402 |
Vascular device infection | 14.56 | 11.65 | 18 | 31807 | 8012 | 70888607 |
Bronchitis | 14.38 | 11.65 | 96 | 31729 | 117147 | 70779472 |
Bladder irritation | 14.34 | 11.65 | 5 | 31820 | 233 | 70896386 |
Intentional product misuse | 14.32 | 11.65 | 9 | 31816 | 79586 | 70817033 |
Suicide attempt | 14.29 | 11.65 | 9 | 31816 | 79501 | 70817118 |
Facial pain | 14.20 | 11.65 | 18 | 31807 | 8218 | 70888401 |
Eosinophilia | 14.11 | 11.65 | 45 | 31780 | 40274 | 70856345 |
White blood cell count decreased | 14.07 | 11.65 | 35 | 31790 | 170106 | 70726513 |
Discomfort | 13.98 | 11.65 | 16 | 31809 | 105420 | 70791199 |
Abnormal weight gain | 13.72 | 11.65 | 10 | 31815 | 2296 | 70894323 |
Oral mucosa erosion | 13.67 | 11.65 | 9 | 31816 | 1756 | 70894863 |
Nasal septum ulceration | 13.66 | 11.65 | 3 | 31822 | 23 | 70896596 |
Helicobacter infection | 13.65 | 11.65 | 4 | 31821 | 55652 | 70840967 |
Reading disorder | 13.63 | 11.65 | 7 | 31818 | 859 | 70895760 |
Skin fragility | 13.63 | 11.65 | 7 | 31818 | 859 | 70895760 |
Oral pain | 13.60 | 11.65 | 36 | 31789 | 29030 | 70867589 |
Abdominal discomfort | 13.57 | 11.65 | 50 | 31775 | 214608 | 70682011 |
Dyspnoea at rest | 13.53 | 11.65 | 16 | 31809 | 6803 | 70889816 |
Respiration abnormal | 13.45 | 11.65 | 16 | 31809 | 6848 | 70889771 |
Hypovolaemia | 13.39 | 11.65 | 25 | 31800 | 15968 | 70880651 |
Reperfusion arrhythmia | 13.34 | 11.65 | 5 | 31820 | 287 | 70896332 |
Convulsive threshold lowered | 13.20 | 11.65 | 7 | 31818 | 917 | 70895702 |
Intentional product use issue | 13.13 | 11.65 | 21 | 31804 | 120121 | 70776498 |
Pneumonia streptococcal | 13.06 | 11.65 | 10 | 31815 | 2473 | 70894146 |
Sleep disorder | 13.04 | 11.65 | 64 | 31761 | 69808 | 70826811 |
Pulmonary oedema | 13.03 | 11.65 | 72 | 31753 | 82206 | 70814413 |
Blood creatinine increased | 12.97 | 11.65 | 28 | 31797 | 142973 | 70753646 |
Lacrimation increased | 12.94 | 11.65 | 28 | 31797 | 19871 | 70876748 |
Insomnia | 12.91 | 11.65 | 152 | 31673 | 217654 | 70678965 |
Mood altered | 12.86 | 11.65 | 25 | 31800 | 16450 | 70880169 |
Beta haemolytic streptococcal infection | 12.78 | 11.65 | 9 | 31816 | 1958 | 70894661 |
Sputum retention | 12.76 | 11.65 | 7 | 31818 | 981 | 70895638 |
Necrosis ischaemic | 12.66 | 11.65 | 7 | 31818 | 997 | 70895622 |
Gastric ulcer perforation | 12.62 | 11.65 | 9 | 31816 | 1998 | 70894621 |
Platelet count increased | 12.58 | 11.65 | 28 | 31797 | 20245 | 70876374 |
Cardio-respiratory arrest | 12.58 | 11.65 | 16 | 31809 | 100661 | 70795958 |
Self-injurious ideation | 12.43 | 11.65 | 11 | 31814 | 3327 | 70893292 |
Locked-in syndrome | 12.39 | 11.65 | 6 | 31819 | 649 | 70895970 |
Hypotension | 12.31 | 11.65 | 119 | 31706 | 404262 | 70492357 |
Derealisation | 12.30 | 11.65 | 8 | 31817 | 1528 | 70895091 |
Sedation | 12.14 | 11.65 | 3 | 31822 | 46728 | 70849891 |
Gastric mucosa erythema | 12.13 | 11.65 | 5 | 31820 | 370 | 70896249 |
Violence-related symptom | 11.92 | 11.65 | 6 | 31819 | 706 | 70895913 |
Multiple organ dysfunction syndrome | 11.82 | 11.65 | 19 | 31806 | 108496 | 70788123 |
Contusion | 11.81 | 11.65 | 98 | 31727 | 127938 | 70768681 |
Stomatitis | 11.79 | 11.65 | 25 | 31800 | 128486 | 70768133 |
Inflammatory myofibroblastic tumour | 11.74 | 11.65 | 4 | 31821 | 174 | 70896445 |
None
Source | Code | Description |
---|---|---|
ATC | A07EA07 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally |
ATC | D07AC15 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
ATC | D07CC04 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, potent, combinations with antibiotics |
ATC | R01AD01 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
ATC | R03AK08 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AK13 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | R03AL09 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
ATC | R03BA01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids |
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
CHEBI has role | CHEBI:50266 | Prodrugs |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D005938 | Glucocorticoids |
MeSH PA | D006728 | Hormones |
MeSH PA | D019141 | Respiratory System Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Nasal polyp | indication | 52756005 | |
Allergic rhinitis | indication | 61582004 | |
Rhinitis | indication | 70076002 | DOID:4483 |
Asthma | indication | 195967001 | DOID:2841 |
Asthma management | indication | 406162001 | |
Severe chronic obstructive pulmonary disease | off-label use | 313299006 | |
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Inactive tuberculosis | contraindication | 11999007 | |
Epistaxis | contraindication | 12441001 | |
Measles | contraindication | 14189004 | DOID:8622 |
Disease caused by parasite | contraindication | 17322007 | |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Acute tuberculosis | contraindication | 25629007 | |
Perforation of nasal septum | contraindication | 80142000 | |
Bacterial infectious disease | contraindication | 87628006 | |
Mycobacteriosis | contraindication | 88415009 | |
Operation on nose | contraindication | 88733004 | |
Bilateral cataracts | contraindication | 95722004 | |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Varicella-zoster virus infection | contraindication | 309465005 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Exposure to varicella | contraindication | 444453009 | |
Nasal Trauma | contraindication | ||
Nasal Candidiasis | contraindication | ||
Nasal Septal Ulcers | contraindication | ||
Uncontrolled Bacterial Infections | contraindication | ||
Untreated Fungal Infection | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.01 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | Ki | 8.43 | DRUG MATRIX | CHEMBL | |||
Interleukin-5 | Cytokine | IC50 | 4.57 | CHEMBL | |||||
Mineralocorticoid receptor | Nuclear hormone receptor | EC50 | 8.32 | CHEMBL | |||||
Matrix metalloproteinase-9 | Enzyme | IC50 | 5.70 | CHEMBL | |||||
Probable G-protein coupled receptor 97 | GPCR | AGONIST | EC50 | 8.50 | IUPHAR | ||||
Progesterone receptor | Nuclear hormone receptor | IC50 | 7.55 | CHEMBL | |||||
Androgen receptor | Transcription factor | Ki | 5.96 | CHEMBL | |||||
Progesterone receptor | Transcription factor | Ki | 7.57 | CHEMBL | |||||
Glucocorticoid receptor | Transcription factor | IC50 | 8.54 | CHEMBL | |||||
Interleukin-5 | Unclassified | IC50 | 4.58 | CHEMBL | |||||
Interleukin-5 receptor subunit alpha | Unclassified | IC50 | 4.58 | CHEMBL |
ID | Source |
---|---|
D00689 | KEGG_DRUG |
1347 | RXNORM |
4018793 | VANDF |
4019625 | VANDF |
C0004906 | UMLSCUI |
CHEBI:3002 | CHEBI |
CHEBI:3001 | CHEBI |
CHEMBL1200500 | ChEMBL_ID |
CHEMBL1370 | ChEMBL_ID |
DB00394 | DRUGBANK_ID |
5894 | IUPHAR_LIGAND_ID |
7059 | IUPHAR_LIGAND_ID |
77011-63-3 | SECONDARY_CAS_RN |
21700 | PUBCHEM_CID |
1167 | MMSL |
4249 | MMSL |
71834 | MMSL |
8263 | MMSL |
d00760 | MMSL |
002179 | NDDF |
004947 | NDDF |
116574000 | SNOMEDCT_US |
116575004 | SNOMEDCT_US |
1389007 | SNOMEDCT_US |
426017007 | SNOMEDCT_US |
D019819 | MESH_DESCRIPTOR_UI |
D001507 | MESH_DESCRIPTOR_UI |
C0004905 | UMLSCUI |
2307 | INN_ID |
4419-39-0 | SECONDARY_CAS_RN |
20469 | PUBCHEM_CID |
5B307S63B2 | UNII |
KGZ1SLC28Z | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
BECONASEAQ | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0388 | SPRAY, SUSPENSION | 42 ug | NASAL | NDA | 20 sections |
BECONASEAQ | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0388 | SPRAY, SUSPENSION | 42 ug | NASAL | NDA | 20 sections |
BECONASE AQ | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-030 | SPRAY, SUSPENSION | 42 ug | NASAL | NDA | 13 sections |
QVAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-860 | AEROSOL, METERED | 40 ug | RESPIRATORY (INHALATION) | NDA | 26 sections |
QVAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1342 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
QVAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3033 | AEROSOL, METERED | 40 ug | RESPIRATORY (INHALATION) | NDA | 28 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3459 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 16 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5031 | AEROSOL, METERED | 40 ug | RESPIRATORY (INHALATION) | NDA | 17 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5032 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 17 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-2436 | AEROSOL, METERED | 40 ug | RESPIRATORY (INHALATION) | NDA | 16 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-3477 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 16 sections |
QVAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5857 | AEROSOL, METERED | 40 ug | RESPIRATORY (INHALATION) | NDA | 14 sections |
QVAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5858 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 14 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-302 | AEROSOL, METERED | 40 ug | RESPIRATORY (INHALATION) | NDA | 17 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-302 | AEROSOL, METERED | 40 ug | RESPIRATORY (INHALATION) | NDA | 17 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-302 | AEROSOL, METERED | 40 ug | RESPIRATORY (INHALATION) | NDA | 17 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-304 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 17 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-304 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 17 sections |
QVAR REDIHALER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-304 | AEROSOL, METERED | 80 ug | RESPIRATORY (INHALATION) | NDA | 17 sections |
QNASL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-406 | AEROSOL, METERED | 40 ug | NASAL | NDA | 27 sections |
QNASL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-406 | AEROSOL, METERED | 40 ug | NASAL | NDA | 27 sections |
QNASL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-406 | AEROSOL, METERED | 40 ug | NASAL | NDA | 27 sections |
QNASL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-410 | AEROSOL, METERED | 80 ug | NASAL | NDA | 27 sections |
QNASL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-410 | AEROSOL, METERED | 80 ug | NASAL | NDA | 27 sections |
QNASL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59310-410 | AEROSOL, METERED | 80 ug | NASAL | NDA | 27 sections |