beclometasone dipropionate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 294 5534-09-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rhinocort
  • beclometasone dipropionate
  • beclomethasone dipropionate
  • beclomethasone dipropionate monohydrate
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
  • Molecular weight: 521.05
  • Formula: C28H37ClO7
  • CLOGP: 4.26
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.40
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 mg N
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
1.50 mg Inhal.solution

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.05 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.29 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 36 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 12, 1976 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 366.04 12.32 304 21363 89033 50494424
Wheezing 167.03 12.32 167 21500 61880 50521577
Dyspnoea 87.04 12.32 462 21205 547146 50036311
Drug ineffective 70.10 12.32 155 21512 819178 49764279
Lip swelling 67.26 12.32 67 21600 24669 50558788
Chest discomfort 66.49 12.32 132 21535 92590 50490867
Depressed mood 65.87 12.32 77 21590 33946 50549511
Cough 61.86 12.32 235 21432 241029 50342428
Swelling face 61.53 12.32 93 21574 52502 50530955
Nightmare 60.06 12.32 52 21615 16034 50567423
Swollen tongue 55.76 12.32 65 21602 28565 50554892
Bronchospasm 55.42 12.32 48 21619 14806 50568651
Rheumatoid arthritis 53.14 12.32 11 21656 202539 50380918
Asthmatic crisis 44.51 12.32 19 21648 1609 50581848
Contraindicated product administered 43.67 12.32 6 21661 148952 50434505
Systemic lupus erythematosus 42.84 12.32 5 21662 140617 50442840
Blood electrolytes abnormal 42.79 12.32 16 21651 957 50582500
Malaise 42.50 12.32 267 21400 335265 50248192
Toxicity to various agents 42.35 12.32 19 21648 212480 50370977
Death 41.44 12.32 47 21620 325332 50258125
Treatment failure 39.29 12.32 6 21661 137631 50445826
Periorbital swelling 38.77 12.32 18 21649 1859 50581598
Transient ischaemic attack 37.72 12.32 57 21610 32153 50551304
Infusion related reaction 37.32 12.32 13 21654 169544 50413913
Separation anxiety disorder 37.12 12.32 7 21660 23 50583434
Arthropathy 36.71 12.32 11 21656 157895 50425562
Flashback 36.30 12.32 9 21658 129 50583328
Bronchial secretion retention 35.96 12.32 16 21651 1497 50581960
Middle insomnia 34.88 12.32 31 21636 9890 50573567
Sputum discoloured 34.06 12.32 35 21632 13360 50570097
Anaphylactic reaction 34.06 12.32 73 21594 53982 50529475
Throat tightness 33.56 12.32 43 21624 20804 50562653
Squamous cell carcinoma of the oral cavity 33.52 12.32 10 21657 295 50583162
Nonspecific reaction 33.48 12.32 16 21651 1763 50581694
Paraesthesia oral 33.02 12.32 33 21634 12188 50571269
Productive cough 33.01 12.32 71 21596 52623 50530834
Eosinophilic granulomatosis with polyangiitis 32.05 12.32 16 21651 1939 50581518
Aggression 31.57 12.32 42 21625 21074 50562383
Bacterial disease carrier 30.86 12.32 12 21655 799 50582658
Infective pulmonary exacerbation of cystic fibrosis 30.40 12.32 26 21641 7883 50575574
Dizziness 30.16 12.32 252 21415 346117 50237340
Obstructive airways disorder 29.58 12.32 35 21632 15617 50567840
Anxiety 29.45 12.32 152 21515 177454 50406003
Miller Fisher syndrome 29.08 12.32 7 21660 88 50583369
Drug monitoring procedure not performed 29.08 12.32 10 21657 469 50582988
Pharyngeal swelling 28.47 12.32 20 21647 4546 50578911
Abdominal rigidity 28.09 12.32 14 21653 1690 50581767
Off label use 27.12 12.32 108 21559 474318 50109139
Limb injury 26.84 12.32 38 21629 20212 50563245
Rash macular 26.78 12.32 37 21630 19240 50564217
Arterial spasm 26.27 12.32 6 21661 59 50583398
Differential white blood cell count abnormal 25.39 12.32 10 21657 689 50582768
Dermatitis allergic 24.96 12.32 29 21638 12691 50570766
Dysmetropsia 24.96 12.32 6 21661 75 50583382
Sinusitis 24.90 12.32 141 21526 170417 50413040
Forced expiratory volume decreased 24.54 12.32 18 21649 4376 50579081
Gastric mucosa erythema 24.38 12.32 7 21660 180 50583277
Eye movement disorder 24.00 12.32 18 21649 4527 50578930
Sleep disorder due to a general medical condition 23.88 12.32 22 21645 7349 50576108
Abdominal discomfort 23.86 12.32 39 21628 231602 50351855
Glossodynia 23.53 12.32 10 21657 115559 50467898
Breast conserving surgery 23.46 12.32 10 21657 844 50582613
Palpitations 23.27 12.32 91 21576 94415 50489042
Pregnancy with implant contraceptive 23.08 12.32 13 21654 2010 50581447
Angioplasty 22.75 12.32 11 21656 1244 50582213
Oropharyngeal pain 22.58 12.32 79 21588 77722 50505735
Idiopathic orbital inflammation 22.18 12.32 6 21661 123 50583334
Secretion discharge 20.35 12.32 23 21644 9768 50573689
Superinfection 20.23 12.32 12 21655 2044 50581413
Urticaria 20.16 12.32 109 21558 129452 50454005
Bronchitis 20 12.32 93 21574 104066 50479391
Gingival swelling 19.97 12.32 15 21652 3780 50579677
Essential tremor 19.83 12.32 9 21658 882 50582575
Sinus operation 19.63 12.32 11 21656 1685 50581772
Facial pain 19.56 12.32 20 21647 7589 50575868
Choking 19.46 12.32 21 21646 8477 50574980
Hiccups 19.37 12.32 11 21656 1728 50581729
Hyponatraemia 19.32 12.32 87 21580 96052 50487405
Anger 19.23 12.32 24 21643 11309 50572148
Therapeutic product effect decreased 19.15 12.32 18 21649 136032 50447425
Gastroenteritis aeromonas 19.11 12.32 4 21663 25 50583432
Peripheral vascular disorder 19.05 12.32 17 21650 5450 50578007
Myalgia 18.95 12.32 104 21563 124215 50459242
Rhinovirus infection 18.67 12.32 14 21653 3520 50579937
Hepatic enzyme increased 18.39 12.32 19 21648 137361 50446096
Tongue pruritus 18.37 12.32 7 21660 441 50583016
Migraine 18.14 12.32 72 21595 75208 50508249
Drug intolerance 18.12 12.32 42 21625 219062 50364395
Nail infection 18.04 12.32 11 21656 1970 50581487
Nasal discomfort 17.43 12.32 14 21653 3890 50579567
Status asthmaticus 17.24 12.32 8 21659 825 50582632
Brain contusion 17.08 12.32 7 21660 535 50582922
Discomfort 16.89 12.32 13 21654 108367 50475090
Alopecia 16.48 12.32 52 21615 244995 50338462
Drug abuse 16.20 12.32 3 21664 59843 50523614
Respiration abnormal 16.09 12.32 15 21652 5087 50578370
Musculoskeletal stiffness 15.84 12.32 19 21648 128462 50454995
Antipsychotic drug level increased 15.72 12.32 12 21655 3097 50580360
Derealisation 15.51 12.32 8 21659 1038 50582419
Pain 15.47 12.32 166 21501 578737 50004720
Oral mucosa erosion 15.45 12.32 8 21659 1047 50582410
Urinary incontinence 15.41 12.32 36 21631 28172 50555285
Malignant neoplasm progression 15.36 12.32 5 21662 68119 50515338
Skin exfoliation 15.30 12.32 40 21627 33572 50549885
Bladder irritation 15.18 12.32 5 21662 205 50583252
Cytomegalovirus enteritis 14.78 12.32 5 21662 223 50583234
Tendonitis 14.72 12.32 26 21641 16679 50566778
Pneumonia streptococcal 14.71 12.32 9 21658 1622 50581835
Reperfusion arrhythmia 14.55 12.32 5 21662 234 50583223
Necrosis ischaemic 14.47 12.32 7 21660 792 50582665
Lacrimation increased 14.40 12.32 26 21641 16966 50566491
Product dosage form issue 13.80 12.32 3 21664 23 50583434
Skin fragility 13.80 12.32 6 21661 531 50582926
Anaemia 13.43 12.32 59 21608 252397 50331060
Headache 13.40 12.32 297 21370 506238 50077219
Platelet count decreased 13.40 12.32 14 21653 100712 50482745
Poor peripheral circulation 13.26 12.32 11 21656 3197 50580260
Mobility decreased 13.22 12.32 9 21658 79939 50503518
Hyperkinesia 13.06 12.32 8 21659 1444 50582013
Oral mucosal blistering 13.01 12.32 13 21654 4799 50578658
Product administered to patient of inappropriate age 12.97 12.32 10 21657 2620 50580837
Nasal discharge discolouration 12.75 12.32 8 21659 1506 50581951
Joint swelling 12.64 12.32 58 21609 245228 50338229
Lethargy 12.49 12.32 48 21619 49384 50534073
Stomatitis 12.48 12.32 15 21652 101329 50482128
Acute myocardial infarction 12.48 12.32 34 21633 29239 50554218
Angioedema 12.47 12.32 40 21627 37636 50545821
Helicobacter infection 12.41 12.32 3 21664 49699 50533758
Viral haemorrhagic cystitis 12.34 12.32 6 21661 687 50582770

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 298.36 12.95 185 12733 33664 29527945
Wheezing 135.83 12.95 114 12804 33126 29528483
Dyspnoea 78.28 12.95 315 12603 326417 29235192
Sleep terror 75.41 12.95 23 12895 718 29560891
Lip swelling 62.18 12.95 48 12870 12362 29549247
Ballismus 60.41 12.95 12 12906 54 29561555
Anger 58.70 12.95 44 12874 10846 29550763
Nightmare 56.85 12.95 44 12874 11373 29550236
Swollen tongue 51.97 12.95 43 12875 12223 29549386
Blood immunoglobulin E increased 44.02 12.95 20 12898 1927 29559682
Lower respiratory tract infection 43.93 12.95 56 12862 26446 29535163
Pharyngeal oedema 42.12 12.95 28 12890 5706 29555903
Infective pulmonary exacerbation of cystic fibrosis 39.99 12.95 28 12890 6208 29555401
Malaise 37.25 12.95 153 12765 159449 29402160
Attention-seeking behaviour 33.85 12.95 7 12911 40 29561569
Nasal disorder 33.12 12.95 15 12903 1434 29560175
Abnormal behaviour 32.38 12.95 45 12873 23082 29538527
Acquired macroglossia 32.11 12.95 6 12912 18 29561591
Anosmia 31.47 12.95 16 12902 1975 29559634
Chest discomfort 29.18 12.95 63 12855 45920 29515689
Neuropsychiatric symptoms 28.58 12.95 10 12908 484 29561125
Chorea 28.42 12.95 12 12906 969 29560640
Cough 26.83 12.95 118 12800 126609 29435000
Dyspnoea at rest 26.81 12.95 17 12901 3197 29558412
Nasal discomfort 25.99 12.95 12 12906 1200 29560409
Sputum discoloured 25.71 12.95 22 12896 6541 29555068
Central obesity 25.05 12.95 9 12909 471 29561138
Daydreaming 25.01 12.95 9 12909 473 29561136
Neonatal hyponatraemia 24.99 12.95 6 12912 73 29561536
Toxicity to various agents 24.34 12.95 24 12894 173637 29387972
Crepitations 24.14 12.95 15 12903 2724 29558885
Death 23.64 12.95 74 12844 342010 29219599
Crying 23.16 12.95 19 12899 5332 29556277
Gastric ulcer perforation 22.98 12.95 10 12908 870 29560739
Paraesthesia oral 22.96 12.95 16 12902 3521 29558088
Gastrointestinal tract irritation 22.75 12.95 7 12911 225 29561384
Micturition urgency 21.62 12.95 18 12900 5155 29556454
Productive cough 21.18 12.95 44 12874 31215 29530394
Neuropsychiatric syndrome 20.89 12.95 5 12913 60 29561549
Spleen congestion 20.78 12.95 7 12911 302 29561307
Cervicogenic headache 20.72 12.95 4 12914 15 29561594
Chronic obstructive pulmonary disease 20.36 12.95 51 12867 40904 29520705
Completed suicide 20.36 12.95 7 12911 90239 29471370
Palpitations 19.91 12.95 44 12874 32560 29529049
Bronchomalacia 19.11 12.95 5 12913 88 29561521
Eye swelling 18.80 12.95 21 12897 8636 29552973
Mesothelioma 18.79 12.95 7 12911 406 29561203
Depressed mood 18.67 12.95 29 12889 16419 29545190
Benign prostatic hyperplasia 18.23 12.95 24 12894 11686 29549923
Mood swings 18.22 12.95 19 12899 7232 29554377
Locked-in syndrome 18.13 12.95 6 12912 245 29561364
Suicidal ideation 18.07 12.95 44 12874 34672 29526937
Malignant neoplasm progression 17.97 12.95 5 12913 73854 29487755
Nasal septum perforation 17.80 12.95 5 12913 116 29561493
Platelet count decreased 17.71 12.95 12 12906 104660 29456949
Self-injurious ideation 17.60 12.95 10 12908 1541 29560068
Convulsive threshold lowered 17.45 12.95 7 12911 496 29561113
Angioedema 17.20 12.95 41 12877 31874 29529735
Antibody test abnormal 17.05 12.95 5 12913 136 29561473
Multifocal motor neuropathy 17.03 12.95 4 12914 44 29561565
Rash papular 16.71 12.95 19 12899 7962 29553647
Hepatic cancer 16.37 12.95 17 12901 6439 29555170
Aortic dissection 15.98 12.95 11 12907 2373 29559236
Urticaria 15.66 12.95 56 12862 54604 29507005
Renal aplasia 15.56 12.95 7 12911 659 29560950
Anaphylactic reaction 15.49 12.95 36 12882 27537 29534072
Tryptase increased 15.32 12.95 5 12913 195 29561414
Thrombocytopenia 15.28 12.95 22 12896 134801 29426808
Sinusitis 15.25 12.95 41 12877 34309 29527300
Ageusia 14.98 12.95 19 12899 8919 29552690
Product administered to patient of inappropriate age 14.91 12.95 11 12907 2644 29558965
Headache 14.83 12.95 128 12790 173879 29387730
Renal failure 14.82 12.95 18 12900 118581 29443028
Eosinophilia 14.78 12.95 31 12887 22130 29539479
Obstructive airways disorder 14.77 12.95 21 12897 10995 29550614
Weaning failure 14.75 12.95 5 12913 220 29561389
Ejaculation failure 14.61 12.95 7 12911 760 29560849
Nasal inflammation 14.53 12.95 5 12913 230 29561379
Neonatal seizure 14.29 12.95 6 12912 478 29561131
Ocular discomfort 14.25 12.95 9 12909 1680 29559929
Violence-related symptom 14.02 12.95 6 12912 501 29561108
Infarction 13.51 12.95 10 12908 2416 29559193
Apnoeic attack 13.15 12.95 5 12913 307 29561302

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 516.24 11.63 395 29555 94830 64373952
Wheezing 263.01 11.63 250 29700 80329 64388453
Dyspnoea 134.03 11.63 672 29278 718002 63750780
Lip swelling 127.51 11.63 111 29839 31796 64436986
Nightmare 124.38 11.63 92 29858 20901 64447881
Swollen tongue 105.54 11.63 104 29846 34850 64433932
Depressed mood 88.34 11.63 102 29848 40910 64427872
Sleep terror 82.31 11.63 28 29922 1169 64467613
Completed suicide 81.24 11.63 6 29944 224408 64244374
Chest discomfort 77.08 11.63 168 29782 115938 64352844
Swelling face 74.40 11.63 113 29837 59053 64409729
Anger 73.67 11.63 60 29890 15681 64453101
Malaise 73.06 11.63 370 29580 395877 64072905
Toxicity to various agents 68.64 11.63 42 29908 363471 64105311
Drug ineffective 66.33 11.63 187 29763 840060 63628722
Infective pulmonary exacerbation of cystic fibrosis 63.88 11.63 49 29901 11747 64457035
Death 59.02 11.63 83 29867 482622 63986160
Sputum discoloured 55.51 11.63 54 29896 17802 64450980
Cough 53.41 11.63 279 29671 301869 64166913
Paraesthesia oral 51.07 11.63 45 29905 13086 64455696
Bronchospasm 48.49 11.63 55 29895 21627 64447155
Drug abuse 46.59 11.63 4 29946 132370 64336412
Ballismus 46.31 11.63 12 29938 190 64468592
Dizziness 45.87 11.63 349 29601 429814 64038968
Pharyngeal oedema 44.63 11.63 45 29905 15486 64453296
Rheumatoid arthritis 44.06 11.63 11 29939 164283 64304499
Separation anxiety disorder 41.84 11.63 8 29942 26 64468756
Asthmatic crisis 41.64 11.63 19 29931 1737 64467045
Productive cough 40.89 11.63 99 29851 73104 64395678
Periorbital swelling 40.44 11.63 19 29931 1857 64466925
Palpitations 40.03 11.63 123 29827 104365 64364417
Infusion related reaction 38.68 11.63 14 29936 164453 64304329
Treatment failure 37.36 11.63 5 29945 116811 64351971
Abnormal behaviour 36.42 11.63 60 29890 33562 64435220
Obstructive airways disorder 36.05 11.63 49 29901 23136 64445646
Eosinophilic granulomatosis with polyangiitis 35.43 11.63 20 29930 2862 64465920
Transient ischaemic attack 35.25 11.63 69 29881 44113 64424669
Off label use 35.08 11.63 163 29787 632643 63836139
Anxiety 34.30 11.63 185 29765 202464 64266318
Aggression 34.24 11.63 70 29880 46162 64422620
Malignant neoplasm progression 33.44 11.63 6 29944 112865 64355917
Crepitations 32.54 11.63 28 29922 7887 64460895
Rash macular 32.28 11.63 47 29903 23638 64445144
Synovitis 32.27 11.63 4 29946 99086 64369696
Blood electrolytes abnormal 32.15 11.63 16 29934 1775 64467007
Attention-seeking behaviour 32.06 11.63 8 29942 108 64468674
Contraindicated product administered 31.37 11.63 6 29944 107823 64360959
Anaphylactic reaction 31.27 11.63 86 29864 68578 64400204
Middle insomnia 31.09 11.63 34 29916 12843 64455939
Bacterial disease carrier 30.80 11.63 13 29937 986 64467796
Angioedema 30.74 11.63 80 29870 61741 64407041
Blood immunoglobulin E increased 30.12 11.63 20 29930 3824 64464958
Dermatitis allergic 29.90 11.63 36 29914 15073 64453709
Pharyngeal swelling 29.89 11.63 23 29927 5536 64463246
Myalgia 29.73 11.63 149 29801 158468 64310314
Forced expiratory volume decreased 29.68 11.63 25 29925 6842 64461940
Urticaria 29.48 11.63 141 29809 147176 64321606
Arthropathy 28.95 11.63 10 29940 120957 64347825
Throat tightness 28.76 11.63 44 29906 23116 64445666
Squamous cell carcinoma of the oral cavity 28.45 11.63 10 29940 461 64468321
Nonspecific reaction 27.64 11.63 15 29935 1988 64466794
Gingival swelling 27.39 11.63 19 29931 3901 64464881
Essential tremor 27.33 11.63 13 29937 1306 64467476
Oropharyngeal pain 27.22 11.63 97 29853 88770 64380012
Antipsychotic drug level increased 27.15 11.63 21 29929 5094 64463688
Bronchial secretion retention 26.98 11.63 16 29934 2511 64466271
Thrombocytopenia 26.77 11.63 39 29911 223762 64245020
Pregnancy with implant contraceptive 26.04 11.63 13 29937 1451 64467331
Breast conserving surgery 26.01 11.63 10 29940 595 64468187
Choking 25.74 11.63 28 29922 10510 64458272
Systemic lupus erythematosus 25.60 11.63 3 29947 77609 64391173
Miller Fisher syndrome 24.72 11.63 7 29943 157 64468625
Platelet count decreased 24.52 11.63 25 29925 167686 64301096
Micturition urgency 24.40 11.63 27 29923 10332 64458450
Sinus operation 24.25 11.63 13 29937 1682 64467100
Limb injury 24.19 11.63 41 29909 23464 64445318
Dysmetropsia 23.78 11.63 6 29944 85 64468697
Crying 23.32 11.63 37 29913 20053 64448729
Anosmia 23.15 11.63 18 29932 4399 64464383
Drug monitoring procedure not performed 23.04 11.63 10 29940 812 64467970
Hallucination 22.76 11.63 80 29870 72708 64396074
Bleeding time prolonged 22.49 11.63 11 29939 1175 64467607
Hepatic enzyme increased 21.84 11.63 17 29933 129926 64338856
Pain 21.82 11.63 159 29791 553352 63915430
Angioplasty 21.55 11.63 12 29938 1673 64467109
Neuropsychiatric symptoms 21.49 11.63 10 29940 956 64467826
Migraine 21.45 11.63 71 29879 62606 64406176
Abdominal rigidity 21.39 11.63 14 29936 2613 64466169
Flashback 21.36 11.63 7 29943 260 64468522
Anaemia 21.24 11.63 97 29853 378583 64090199
Idiopathic orbital inflammation 20.89 11.63 6 29944 142 64468640
Arterial spasm 20.35 11.63 6 29944 156 64468626
Nasal disorder 20.20 11.63 14 29936 2870 64465912
Mood swings 20.04 11.63 32 29918 17436 64451346
Daydreaming 19.95 11.63 9 29941 801 64467981
Irritability 19.77 11.63 49 29901 36697 64432085
Headache 19.65 11.63 350 29600 529117 63939665
Chorea 19.64 11.63 12 29938 1988 64466794
Febrile neutropenia 19.36 11.63 36 29914 187621 64281161
Ejaculation failure 19.29 11.63 7 29943 354 64468428
Suicidal ideation 19.00 11.63 71 29879 66471 64402311
Cervicogenic headache 18.79 11.63 4 29946 25 64468757
Gastroenteritis aeromonas 18.79 11.63 4 29946 25 64468757
Acquired macroglossia 18.73 11.63 6 29944 207 64468575
Disease progression 18.65 11.63 23 29927 141657 64327125
Sleep disorder due to a general medical condition 18.60 11.63 21 29929 8213 64460569
Nasal discharge discolouration 18.45 11.63 11 29939 1743 64467039
Product administered to patient of inappropriate age 18.36 11.63 16 29934 4585 64464197
Liver function test abnormal 18.32 11.63 65 29885 59336 64409446
Skin exfoliation 18.27 11.63 54 29896 44831 64423951
Disturbance in attention 18.25 11.63 51 29899 41023 64427759
Secretion discharge 18.16 11.63 25 29925 11939 64456843
Differential white blood cell count abnormal 18.13 11.63 11 29939 1799 64466983
Upper gastrointestinal haemorrhage 17.94 11.63 46 29904 35174 64433608
Nail infection 17.93 11.63 11 29939 1836 64466946
Spleen congestion 17.91 11.63 7 29943 435 64468347
Renal failure 17.75 11.63 36 29914 181652 64287130
Eye movement disorder 17.63 11.63 19 29931 7060 64461722
Central obesity 17.62 11.63 10 29940 1445 64467337
Neuropsychiatric syndrome 17.38 11.63 5 29945 119 64468663
Psychomotor hyperactivity 17.31 11.63 27 29923 14424 64454358
Tongue pruritus 17.24 11.63 7 29943 481 64468301
Benign prostatic hyperplasia 16.78 11.63 21 29929 9144 64459638
Multifocal motor neuropathy 16.78 11.63 4 29946 44 64468738
Poor peripheral circulation 16.68 11.63 13 29937 3187 64465595
Tendonitis 16.57 11.63 32 29918 20250 64448532
Gastrointestinal tract irritation 16.48 11.63 7 29943 539 64468243
Infection 16.11 11.63 39 29911 184841 64283941
Encephalopathy 15.64 11.63 4 29946 58815 64409967
Hyponatraemia 15.54 11.63 120 29830 148219 64320563
Peripheral vascular disorder 15.53 11.63 18 29932 7243 64461539
Status asthmaticus 15.48 11.63 8 29942 960 64467822
Muscle spasms 15.29 11.63 115 29835 140908 64327874
Pericarditis 15.25 11.63 5 29945 62511 64406271
Urinary incontinence 15.20 11.63 44 29906 36107 64432675
Lactic acidosis 14.82 11.63 5 29945 61405 64407377
Bronchomalacia 14.51 11.63 5 29945 217 64468565
Eye swelling 14.49 11.63 32 29918 22249 64446533
Overdose 14.43 11.63 33 29917 159533 64309249
Rhinovirus infection 14.42 11.63 16 29934 6140 64462642
Lower respiratory tract infection 14.40 11.63 84 29866 94530 64374252
Bladder irritation 14.32 11.63 5 29945 226 64468556
Facial pain 14.31 11.63 18 29932 7877 64460905
Hypotension 14.24 11.63 111 29839 380863 64087919
Ageusia 14.09 11.63 24 29926 13789 64454993
Pulmonary congestion 14.09 11.63 33 29917 23847 64444935
Respiration abnormal 14.08 11.63 16 29934 6299 64462483
Dyspnoea at rest 14.06 11.63 16 29934 6313 64462469
Cardio-respiratory arrest 14.00 11.63 15 29935 98378 64370404
Skin fragility 13.94 11.63 7 29943 791 64467991
Abnormal weight gain 13.78 11.63 10 29940 2203 64466579
Nasal septum ulceration 13.56 11.63 3 29947 23 64468759
Platelet count increased 13.48 11.63 28 29922 18668 64450114
Hypovolaemia 13.35 11.63 25 29925 15461 64453321
Gastric ulcer perforation 13.26 11.63 9 29941 1784 64466998
Reperfusion arrhythmia 13.17 11.63 5 29945 287 64468495
Convulsive threshold lowered 13.16 11.63 7 29943 892 64467890
Pneumonia streptococcal 13.14 11.63 10 29940 2368 64466414
Syncope 13.05 11.63 121 29829 157514 64311268
Blood pressure fluctuation 12.91 11.63 4 29946 51867 64416915
Beta haemolytic streptococcal infection 12.81 11.63 9 29941 1885 64466897
Mood altered 12.79 11.63 25 29925 15954 64452828
Intentional product misuse 12.73 11.63 9 29941 72286 64396496
Orthostatic hypotension 12.62 11.63 49 29901 46689 64422093
Necrosis ischaemic 12.57 11.63 7 29943 976 64467806
Superinfection 12.54 11.63 12 29938 3874 64464908
Self-injurious ideation 12.52 11.63 11 29939 3186 64465596
Drug intolerance 12.51 11.63 45 29905 187947 64280835
White blood cell count decreased 12.45 11.63 35 29915 157802 64310980
Contusion 12.38 11.63 93 29857 113872 64354910
Musculoskeletal stiffness 12.38 11.63 24 29926 123182 64345600
Locked-in syndrome 12.36 11.63 6 29944 630 64468152
Blood creatinine increased 12.34 11.63 28 29922 135754 64333028
Suicide attempt 12.30 11.63 9 29941 70998 64397784
Vaginal discharge 12.26 11.63 12 29938 3985 64464797
Derealisation 12.25 11.63 8 29942 1487 64467295
Graft versus host disease in gastrointestinal tract 12.15 11.63 14 29936 5598 64463184
Eosinophilia 12.03 11.63 42 29908 38034 64430748
Hepatic cancer 11.97 11.63 16 29934 7432 64461350
Gastric mucosa erythema 11.96 11.63 5 29945 370 64468412
Nasal pruritus 11.90 11.63 5 29945 375 64468407
Pancytopenia 11.89 11.63 31 29919 143278 64325504
Violence-related symptom 11.86 11.63 6 29944 689 64468093
Nasal congestion 11.84 11.63 57 29893 59601 64409181
Inflammatory myofibroblastic tumour 11.80 11.63 4 29946 165 64468617
Rhonchi 11.76 11.63 11 29939 3452 64465330
Polyp 11.76 11.63 15 29935 6658 64462124

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EA07 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC D07AC15 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07CC04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
ATC R01AD01 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03AK08 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL09 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03BA01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:50266 Prodrugs
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D019141 Respiratory System Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Nasal polyp indication 52756005
Allergic rhinitis indication 61582004
Rhinitis indication 70076002 DOID:4483
Asthma indication 195967001 DOID:2841
Asthma management indication 406162001
Severe chronic obstructive pulmonary disease off-label use 313299006
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Inactive tuberculosis contraindication 11999007
Epistaxis contraindication 12441001
Measles contraindication 14189004 DOID:8622
Disease caused by parasite contraindication 17322007
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Perforation of nasal septum contraindication 80142000
Bacterial infectious disease contraindication 87628006
Mycobacteriosis contraindication 88415009
Operation on nose contraindication 88733004
Bilateral cataracts contraindication 95722004
Ophthalmic herpes simplex contraindication 186542001
Disease of liver contraindication 235856003 DOID:409
Varicella-zoster virus infection contraindication 309465005
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Exposure to varicella contraindication 444453009
Nasal Trauma contraindication
Nasal Candidiasis contraindication
Nasal Septal Ulcers contraindication
Uncontrolled Bacterial Infections contraindication
Untreated Fungal Infection contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.01 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 8.43 DRUG MATRIX CHEMBL
Interleukin-5 Cytokine IC50 4.57 CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor EC50 8.32 CHEMBL
Matrix metalloproteinase-9 Enzyme IC50 5.70 CHEMBL
Probable G-protein coupled receptor 97 GPCR AGONIST EC50 8.50 IUPHAR
Progesterone receptor Nuclear hormone receptor IC50 7.55 CHEMBL
Androgen receptor Transcription factor Ki 5.96 CHEMBL
Progesterone receptor Transcription factor Ki 7.57 CHEMBL
Glucocorticoid receptor Transcription factor IC50 8.54 CHEMBL
Interleukin-5 Unclassified IC50 4.58 CHEMBL
Interleukin-5 receptor subunit alpha Unclassified IC50 4.58 CHEMBL

External reference:

IDSource
D00689 KEGG_DRUG
77011-63-3 SECONDARY_CAS_RN
1347 RXNORM
C0004906 UMLSCUI
CHEBI:3002 CHEBI
CHEBI:3001 CHEBI
CHEMBL1200500 ChEMBL_ID
CHEMBL1370 ChEMBL_ID
DB00394 DRUGBANK_ID
5894 IUPHAR_LIGAND_ID
7059 IUPHAR_LIGAND_ID
4419-39-0 SECONDARY_CAS_RN
21700 PUBCHEM_CID
20469 PUBCHEM_CID
1167 MMSL
4249 MMSL
71834 MMSL
8263 MMSL
d00760 MMSL
002179 NDDF
004947 NDDF
4018793 VANDF
4019625 VANDF
D019819 MESH_DESCRIPTOR_UI
D001507 MESH_DESCRIPTOR_UI
C0004905 UMLSCUI
2307 INN_ID
116574000 SNOMEDCT_US
116575004 SNOMEDCT_US
1389007 SNOMEDCT_US
426017007 SNOMEDCT_US
5B307S63B2 UNII
KGZ1SLC28Z UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BECONASEAQ HUMAN PRESCRIPTION DRUG LABEL 1 0173-0388 SPRAY, SUSPENSION 42 ug NASAL NDA 20 sections
BECONASE AQ HUMAN PRESCRIPTION DRUG LABEL 1 16590-030 SPRAY, SUSPENSION 42 ug NASAL NDA 13 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 16590-860 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 26 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 50090-1342 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 28 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 50090-3033 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 28 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 50090-3459 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 50090-5031 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 50090-5032 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 53002-2436 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 53002-3477 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 54868-5857 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 14 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 54868-5858 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 14 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-302 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-302 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-304 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-304 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 17 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-406 AEROSOL, METERED 40 ug NASAL NDA 27 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-406 AEROSOL, METERED 40 ug NASAL NDA 27 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-410 AEROSOL, METERED 80 ug NASAL NDA 27 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-410 AEROSOL, METERED 80 ug NASAL NDA 27 sections