beclometasone dipropionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	294	5534-09-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: rhinocort beclometasone dipropionate beclomethasone dipropionate beclomethasone dipropionate monohydrate	An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA. Molecular weight: 521.05 Formula: C28H37ClO7 CLOGP: 4.26 LIPINSKI: 1 HAC: 7 HDO: 1 TPSA: 106.97 ALOGS: -5.40 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

rhinocort
beclometasone dipropionate
beclomethasone dipropionate
beclomethasone dipropionate monohydrate

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

Molecular weight: 521.05
Formula: C28H37ClO7
CLOGP: 4.26
LIPINSKI: 1
HAC: 7
HDO: 1
TPSA: 106.97
ALOGS: -5.40
ROTB: 8

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	mg	N
0.80	mg	Inhal.aerosol
0.80	mg	Inhal.powder
1.50	mg	Inhal.solution

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.05 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	0.29 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	36 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.13 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.50 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
May 12, 1976	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	510.78	12.62	402	23042	112368	56156255
Wheezing	181.15	12.62	188	23256	74838	56193785
Rheumatoid arthritis	119.41	12.62	11	23433	382593	55886030
Dyspnoea	95.54	12.62	492	22952	592085	55676538
Depressed mood	85.67	12.62	90	23354	36269	56232354
Drug ineffective	83.38	12.62	161	23283	918828	55349795
Nightmare	80.24	12.62	62	23382	16764	56251859
Chest discomfort	80.22	12.62	146	23298	98711	56169912
Cough	80.11	12.62	264	23180	259697	56008926
Lip swelling	69.08	12.62	69	23375	26203	56242420
Swelling face	67.48	12.62	99	23345	55970	56212653
Bronchospasm	66.69	12.62	54	23390	15615	56253008
Swollen tongue	59.17	12.62	68	23376	30256	56238367
Contraindicated product administered	56.34	12.62	6	23438	186280	56082343
Arthropathy	50.24	12.62	11	23433	200264	56068359
Treatment failure	50.23	12.62	6	23438	170386	56098237
Infusion related reaction	49.42	12.62	13	23431	208918	56059705
Transient ischaemic attack	45.87	12.62	63	23381	33514	56235109
Asthmatic crisis	44.11	12.62	19	23425	1691	56266932
Aggression	44.03	12.62	50	23394	21956	56246667
Separation anxiety disorder	43.19	12.62	8	23436	24	56268599
Blood electrolytes abnormal	43.02	12.62	16	23428	970	56267653
Toxicity to various agents	42.79	12.62	20	23424	224544	56044079
Bronchial secretion retention	42.50	12.62	19	23425	1849	56266774
Death	42.26	12.62	48	23396	341378	55927245
Malaise	41.19	12.62	278	23166	367582	55901041
Bacterial disease carrier	40.41	12.62	15	23429	904	56267719
Sputum discoloured	40.29	12.62	39	23405	14253	56254370
Throat tightness	36.74	12.62	46	23398	22361	56246262
Flashback	36.16	12.62	9	23435	135	56268488
Nonspecific reaction	36.10	12.62	17	23427	1864	56266759
Systemic lupus erythematosus	35.93	12.62	15	23429	180063	56088560
Periorbital swelling	35.93	12.62	18	23426	2260	56266363
Off label use	35.70	12.62	116	23328	556064	55712559
Glossodynia	35.07	12.62	10	23434	152448	56116175
Productive cough	34.61	12.62	74	23370	56158	56212465
Pericarditis	34.25	12.62	3	23441	108920	56159703
Squamous cell carcinoma of the oral cavity	33.69	12.62	10	23434	298	56268325
Abdominal discomfort	33.19	12.62	40	23404	277234	55991389
Middle insomnia	32.99	12.62	31	23413	10919	56257704
Eosinophilic granulomatosis with polyangiitis	31.67	12.62	16	23428	2045	56266578
Anaphylactic reaction	31.11	12.62	73	23371	58922	56209701
Paraesthesia oral	30.91	12.62	34	23410	14415	56254208
Obstructive airways disorder	30.79	12.62	37	23407	17245	56251378
Dizziness	30.69	12.62	264	23180	375876	55892747
Infective pulmonary exacerbation of cystic fibrosis	30.32	12.62	26	23418	8131	56260492
Oropharyngeal pain	30.23	12.62	90	23354	83698	56184925
Anxiety	29.90	12.62	159	23285	193013	56075610
Breast conserving surgery	29.68	12.62	12	23432	911	56267712
Palpitations	29.51	12.62	100	23344	99572	56169051
Gastric mucosa erythema	29.33	12.62	9	23435	301	56268322
Miller Fisher syndrome	29.27	12.62	7	23437	88	56268535
Limb injury	29.23	12.62	41	23403	22229	56246394
Angioplasty	28.56	12.62	13	23431	1319	56267304
Bronchitis	28.39	12.62	107	23337	112204	56156419
Sinusitis	28.15	12.62	159	23285	197422	56071201
Drug monitoring procedure not performed	28.14	12.62	10	23434	532	56268091
Therapeutic product effect decreased	28.04	12.62	18	23426	169434	56099189
Superinfection	27.93	12.62	15	23429	2173	56266450
Abdominal rigidity	27.85	12.62	14	23430	1771	56266852
Hepatic enzyme increased	27.29	12.62	19	23425	171365	56097258
Hiccups	26.42	12.62	14	23430	1974	56266649
Discomfort	26.41	12.62	13	23431	141748	56126875
Arterial spasm	26.34	12.62	6	23438	60	56268563
Pharyngeal swelling	26.27	12.62	20	23424	5286	56263337
Sleep disorder due to a general medical condition	25.99	12.62	25	23419	9065	56259558
Rash macular	25.67	12.62	37	23407	20567	56248056
Differential white blood cell count abnormal	25.21	12.62	10	23434	722	56267901
Essential tremor	25.19	12.62	11	23433	1012	56267611
Dysmetropsia	25.12	12.62	6	23438	75	56268548
Drug intolerance	25.04	12.62	45	23399	264773	56003850
Peripheral vascular disorder	24.93	12.62	20	23424	5705	56262918
Choking	24.33	12.62	24	23420	8973	56259650
Nail infection	24.21	12.62	14	23430	2339	56266284
Forced expiratory volume decreased	24.04	12.62	18	23426	4642	56263981
Eye movement disorder	23.60	12.62	18	23426	4771	56263852
Genital pain	23.50	12.62	8	23436	374	56268249
Dermatitis allergic	23.40	12.62	29	23415	13949	56254674
Alopecia	23.40	12.62	55	23389	293403	55975220
Hyponatraemia	23.13	12.62	94	23350	102045	56166578
Musculoskeletal stiffness	22.66	12.62	19	23425	155988	56112635
Idiopathic orbital inflammation	22.30	12.62	6	23438	124	56268499
Pregnancy with implant contraceptive	22.03	12.62	13	23431	2255	56266368
Myalgia	22.03	12.62	111	23333	131914	56136709
Vascular device infection	21.15	12.62	18	23426	5572	56263051
Helicobacter infection	20.57	12.62	3	23441	73265	56195358
Lacrimation increased	20.07	12.62	31	23413	18317	56250306
Status asthmaticus	19.90	12.62	9	23435	900	56267723
Gingival swelling	19.62	12.62	15	23429	3991	56264632
Joint swelling	19.55	12.62	59	23385	289741	55978882
Facial pain	19.48	12.62	20	23424	7838	56260785
Secretion discharge	19.48	12.62	23	23421	10523	56258100
Gastroenteritis aeromonas	19.22	12.62	4	23440	25	56268598
Anger	19.19	12.62	24	23420	11648	56256975
Poor peripheral circulation	19.07	12.62	14	23430	3503	56265120
Duodenal ulcer perforation	18.73	12.62	3	23441	68339	56200284
Illness	18.51	12.62	43	23401	34468	56234155
Pain	18.48	12.62	182	23262	663002	55605621
Urticaria	18.37	12.62	113	23331	144563	56124060
Oral mucosal blistering	18.35	12.62	16	23428	5118	56263505
Butterfly rash	18.32	12.62	10	23434	1496	56267127
Tongue pruritus	18.04	12.62	7	23437	477	56268146
Sinus operation	17.98	12.62	11	23433	2037	56266586
Genital ulceration	17.81	12.62	7	23437	493	56268130
Rhinovirus infection	17.71	12.62	14	23430	3908	56264715
Hyperkinesia	17.53	12.62	10	23434	1629	56266994
Brain contusion	17.08	12.62	7	23437	550	56268073
Nasal discomfort	17.07	12.62	14	23430	4118	56264505
Respiration abnormal	17.05	12.62	16	23428	5625	56262998
Migraine	16.66	12.62	76	23368	86721	56181902
Malignant neoplasm progression	16.60	12.62	5	23439	73582	56195041
Drug abuse	16.36	12.62	4	23440	67606	56201017
Angioedema	16.36	12.62	46	23398	41407	56227216
Tendonitis	16.29	12.62	28	23416	18069	56250554
Vaginal discharge	15.85	12.62	16	23428	6147	56262476
Antipsychotic drug level increased	15.57	12.62	12	23432	3230	56265393
Derealisation	15.47	12.62	8	23436	1073	56267550
Acute myocardial infarction	15.36	12.62	37	23407	30356	56238267
Oral mucosa erosion	15.34	12.62	8	23436	1092	56267531
Bladder irritation	15.13	12.62	5	23439	213	56268410
Urinary incontinence	14.93	12.62	36	23408	29549	56239074
Stomatitis	14.89	12.62	17	23427	120793	56147830
Pulmonary oedema	14.85	12.62	51	23393	51092	56217531
Maternal exposure during pregnancy	14.72	12.62	36	23408	189517	56079106
Reperfusion arrhythmia	14.68	12.62	5	23439	234	56268389
Pneumonia streptococcal	14.65	12.62	9	23435	1679	56266944
Skin exfoliation	14.62	12.62	41	23403	36859	56231764
Pulmonary congestion	14.60	12.62	25	23419	16090	56252533
Blood cholesterol increased	14.54	12.62	6	23438	72573	56196050
Cytomegalovirus enteritis	14.52	12.62	5	23439	242	56268381
Necrosis ischaemic	14.49	12.62	7	23437	812	56267811
Crepitations	14.19	12.62	16	23428	6968	56261655
Product dosage form issue	13.77	12.62	3	23441	24	56268599
Impaired healing	13.33	12.62	10	23434	86831	56181792
Impaired quality of life	13.26	12.62	17	23427	8457	56260166
Mobility decreased	13.24	12.62	13	23431	98978	56169645
Anaemia	13.13	12.62	62	23382	267449	56001174
Platelet count decreased	13.08	12.62	15	23429	106368	56162255
Skin fragility	12.91	12.62	6	23438	639	56267984
Febrile neutropenia	12.85	12.62	15	23429	105530	56163093
Abnormal behaviour	12.84	12.62	27	23417	20245	56248378

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	351.87	13.37	222	13393	42389	31641340
Wheezing	135.66	13.37	117	13498	35869	31647860
Dyspnoea	84.44	13.37	330	13285	343149	31340580
Sleep terror	75.30	13.37	23	13592	734	31682995
Lip swelling	64.17	13.37	50	13565	13273	31670456
Anger	62.91	13.37	46	13569	11107	31672622
Ballismus	60.61	13.37	12	13603	54	31683675
Nightmare	55.12	13.37	44	13571	12093	31671636
Swollen tongue	50.81	13.37	43	13572	12819	31670910
Blood immunoglobulin E increased	47.92	13.37	22	13593	2209	31681520
Lower respiratory tract infection	43.41	13.37	57	13558	28180	31655549
Pharyngeal oedema	42.28	13.37	28	13587	5768	31677961
Abnormal behaviour	41.20	13.37	51	13564	23777	31659952
Infective pulmonary exacerbation of cystic fibrosis	39.43	13.37	28	13587	6456	31677273
Malaise	37.21	13.37	157	13458	168354	31515375
Attention-seeking behaviour	33.96	13.37	7	13608	40	31683689
Nasal disorder	33.82	13.37	16	13599	1719	31682010
Acquired macroglossia	32.21	13.37	6	13609	18	31683711
Anosmia	30.86	13.37	16	13599	2092	31681637
Chorea	28.39	13.37	12	13603	988	31682741
Neuropsychiatric symptoms	28.17	13.37	10	13605	514	31683215
Chest discomfort	27.97	13.37	64	13551	49305	31634424
Cough	27.73	13.37	123	13492	134691	31549038
Chronic obstructive pulmonary disease	26.08	13.37	59	13556	45107	31638622
Crepitations	25.96	13.37	16	13599	2912	31680817
Toxicity to various agents	25.79	13.37	24	13591	181463	31502266
Dyspnoea at rest	25.61	13.37	17	13598	3514	31680215
Sputum discoloured	25.42	13.37	22	13593	6754	31676975
Neonatal hyponatraemia	25.09	13.37	6	13609	73	31683656
Death	25.00	13.37	76	13539	360493	31323236
Central obesity	24.82	13.37	9	13606	492	31683237
Daydreaming	24.54	13.37	9	13606	508	31683221
Nasal discomfort	23.44	13.37	12	13603	1528	31682201
Gastrointestinal tract irritation	22.72	13.37	7	13608	230	31683499
Crying	22.69	13.37	19	13596	5578	31678151
Paraesthesia oral	22.52	13.37	16	13599	3692	31680037
Gastric ulcer perforation	22.01	13.37	10	13605	980	31682749
Productive cough	21.85	13.37	46	13569	33494	31650235
Depressed mood	21.79	13.37	32	13583	17543	31666186
Neuropsychiatric syndrome	20.97	13.37	5	13610	60	31683669
Spleen congestion	20.89	13.37	7	13608	302	31683427
Cervicogenic headache	20.79	13.37	4	13611	15	31683714
Completed suicide	20.27	13.37	7	13608	91507	31592222
Micturition urgency	20.20	13.37	18	13597	5742	31677987
Malignant neoplasm progression	19.39	13.37	5	13610	78993	31604736
Bronchomalacia	19.19	13.37	5	13610	88	31683641
Sinusitis	19.06	13.37	46	13569	36650	31647079
Platelet count decreased	18.99	13.37	12	13603	110423	31573306
Mesothelioma	18.71	13.37	7	13608	418	31683311
Palpitations	18.67	13.37	44	13571	34539	31649190
Mood swings	18.11	13.37	19	13596	7405	31676324
Eye swelling	18.09	13.37	21	13594	9155	31674574
Locked-in syndrome	17.93	13.37	6	13609	258	31683471
Self-injurious ideation	17.54	13.37	10	13605	1577	31682152
Nasal septum perforation	17.53	13.37	5	13610	125	31683604
Convulsive threshold lowered	17.41	13.37	7	13608	508	31683221
Suicidal ideation	17.19	13.37	44	13571	36362	31647367
Multifocal motor neuropathy	16.85	13.37	4	13611	47	31683682
Graft versus host disease in gastrointestinal tract	16.62	13.37	13	13602	3466	31680263
Off label use	16.51	13.37	85	13530	347189	31336540
Benign prostatic hyperplasia	16.42	13.37	24	13591	13101	31670628
Angioedema	16.25	13.37	41	13574	33577	31650152
Apnoeic attack	16.24	13.37	6	13609	346	31683383
Rash papular	16.20	13.37	19	13596	8373	31675356
Ocular discomfort	15.96	13.37	10	13605	1873	31681856
Aortic dissection	15.58	13.37	11	13604	2511	31681218
Cystic fibrosis	15.56	13.37	10	13605	1956	31681773
Urticaria	15.40	13.37	57	13558	57460	31626269
Renal aplasia	15.32	13.37	7	13608	695	31683034
Antibody test abnormal	15.26	13.37	5	13610	201	31683528
Tryptase increased	15.07	13.37	5	13610	209	31683520
Headache	14.95	13.37	132	13483	183520	31500209
Thrombocytopenia	14.86	13.37	24	13591	142723	31541006
Sleep disorder	14.74	13.37	34	13581	26314	31657415
Ejaculation failure	14.69	13.37	7	13608	764	31682965
Ageusia	14.58	13.37	19	13596	9312	31674417
Renal failure	14.54	13.37	19	13596	123311	31560418
Nasal inflammation	14.49	13.37	5	13610	236	31683493
Weaning failure	14.49	13.37	5	13610	236	31683493
Sleep talking	14.44	13.37	6	13609	473	31683256
Neonatal seizure	14.38	13.37	6	13609	478	31683251
Product administered to patient of inappropriate age	14.36	13.37	11	13604	2846	31680883
Anaphylactic reaction	14.24	13.37	36	13579	29517	31654212
Obstructive airways disorder	14.19	13.37	22	13593	12642	31671087
Abdominal symptom	14.12	13.37	6	13609	501	31683228
Eosinophilia	14.12	13.37	31	13584	23222	31660507
Insomnia	14.12	13.37	79	13536	94757	31588972
Hepatic cancer	14.01	13.37	17	13598	7758	31675971
Reading disorder	13.96	13.37	6	13609	515	31683214
Violence-related symptom	13.95	13.37	6	13609	516	31683213
Oral pain	13.91	13.37	19	13596	9746	31673983

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Asthma	681.77	11.65	506	31319	120287	70776332
Wheezing	266.43	11.65	266	31559	93904	70802715
Dyspnoea	148.99	11.65	710	31115	769350	70127269
Nightmare	145.56	11.65	102	31723	22054	70874565
Lip swelling	132.55	11.65	115	31710	33939	70862680
Depressed mood	113.27	11.65	118	31707	43702	70852917
Swollen tongue	108.99	11.65	107	31718	36939	70859680
Rheumatoid arthritis	92.91	11.65	11	31814	291794	70604825
Chest discomfort	85.66	11.65	179	31646	124202	70772417
Sleep terror	82.85	11.65	28	31797	1187	70895432
Completed suicide	79.06	11.65	6	31819	227129	70669490
Drug ineffective	75.55	11.65	197	31628	939555	69957064
Anger	74.18	11.65	60	31765	16072	70880547
Swelling face	73.13	11.65	114	31711	63050	70833569
Malaise	71.83	11.65	383	31442	432549	70464070
Toxicity to various agents	69.26	11.65	43	31782	382129	70514490
Cough	65.36	11.65	304	31521	325073	70571546
Infective pulmonary exacerbation of cystic fibrosis	64.05	11.65	49	31776	12109	70884510
Sputum discoloured	62.16	11.65	58	31767	18793	70877826
Death	59.01	11.65	86	31739	509975	70386644
Bronchospasm	58.21	11.65	61	31764	22731	70873888
Abnormal behaviour	55.40	11.65	73	31752	34636	70861983
Infusion related reaction	48.88	11.65	14	31811	197520	70699099
Dizziness	48.46	11.65	365	31460	463776	70432843
Drug abuse	48.23	11.65	5	31820	147251	70749368
Paraesthesia oral	48.09	11.65	46	31779	15371	70881248
Separation anxiety disorder	47.92	11.65	9	31816	27	70896592
Palpitations	46.75	11.65	132	31693	110621	70785998
Ballismus	46.49	11.65	12	31813	194	70896425
Off label use	46.00	11.65	175	31650	742885	70153734
Pharyngeal oedema	45.53	11.65	45	31780	15651	70880968
Treatment failure	44.46	11.65	6	31819	144136	70752483
Productive cough	44.04	11.65	104	31721	78233	70818386
Synovitis	43.33	11.65	4	31821	129224	70767395
Transient ischaemic attack	42.52	11.65	75	31750	45869	70850750
Asthmatic crisis	40.99	11.65	19	31806	1865	70894754
Contraindicated product administered	40.59	11.65	6	31819	134606	70762013
Bacterial disease carrier	40.31	11.65	16	31809	1073	70895546
Crepitations	39.19	11.65	32	31793	8682	70887937
Aggression	38.43	11.65	74	31751	48372	70848247
Arthropathy	38.31	11.65	10	31815	150047	70746572
Periorbital swelling	37.94	11.65	19	31806	2211	70894408
Obstructive airways disorder	37.23	11.65	52	31773	26061	70870558
Malignant neoplasm progression	35.41	11.65	6	31819	121733	70774886
Myalgia	34.47	11.65	158	31667	167734	70728885
Eosinophilic granulomatosis with polyangiitis	34.05	11.65	20	31805	3193	70893426
Anxiety	33.78	11.65	191	31634	220139	70676480
Essential tremor	32.75	11.65	15	31810	1432	70895187
Bronchial secretion retention	32.59	11.65	19	31806	2991	70893628
Breast conserving surgery	32.51	11.65	12	31813	660	70895959
Blood electrolytes abnormal	32.47	11.65	16	31809	1798	70894821
Oropharyngeal pain	32.39	11.65	106	31719	96204	70800415
Attention-seeking behaviour	32.33	11.65	8	31817	108	70896511
Pharyngeal swelling	31.80	11.65	25	31800	6428	70890191
Throat tightness	31.54	11.65	47	31778	24975	70871644
Blood immunoglobulin E increased	31.52	11.65	22	31803	4722	70891897
Middle insomnia	31.31	11.65	35	31790	14018	70882601
Rash macular	30.81	11.65	47	31778	25497	70871122
Choking	30.77	11.65	31	31794	11029	70885590
Angioedema	30.69	11.65	82	31743	66528	70830091
Nonspecific reaction	30.22	11.65	16	31809	2089	70894530
Crying	29.90	11.65	42	31783	21157	70875462
Hepatic enzyme increased	29.32	11.65	17	31808	156973	70739646
Forced expiratory volume decreased	29.05	11.65	25	31800	7289	70889330
Anosmia	28.66	11.65	21	31804	4862	70891757
Dermatitis allergic	28.47	11.65	36	31789	16395	70880224
Anaphylactic reaction	28.41	11.65	86	31739	74888	70821731
Squamous cell carcinoma of the oral cavity	28.16	11.65	10	31815	492	70896127
Urticaria	28.13	11.65	146	31679	162903	70733716
Gingival swelling	27.09	11.65	19	31806	4110	70892509
Thrombocytopenia	26.92	11.65	41	31784	239069	70657550
Angioplasty	26.75	11.65	14	31811	1786	70894833
Antipsychotic drug level increased	26.64	11.65	21	31804	5419	70891200
Limb injury	26.40	11.65	44	31781	25708	70870911
Pregnancy with implant contraceptive	25.30	11.65	13	31812	1596	70895023
Platelet count decreased	24.80	11.65	26	31799	178196	70718423
Nail infection	24.17	11.65	14	31811	2177	70894442
Disturbance in attention	24.16	11.65	57	31768	42837	70853782
Dysmetropsia	23.98	11.65	6	31819	85	70896534
Miller Fisher syndrome	23.76	11.65	7	31818	188	70896431
Pain	23.74	11.65	175	31650	628641	70267978
Micturition urgency	23.21	11.65	27	31798	11287	70885332
Pericarditis	22.88	11.65	5	31820	84700	70811919
Poor peripheral circulation	22.78	11.65	16	31809	3469	70893150
Sinus operation	22.73	11.65	13	31812	1974	70894645
Drug monitoring procedure not performed	22.54	11.65	10	31815	886	70895733
Bleeding time prolonged	22.49	11.65	11	31814	1217	70895402
Peripheral vascular disorder	22.35	11.65	22	31803	7610	70889009
Hallucination	22.19	11.65	80	31745	76180	70820439
Febrile neutropenia	22.07	11.65	36	31789	204282	70692337
Anaemia	21.78	11.65	100	31725	403323	70493296
Flashback	21.42	11.65	7	31818	267	70896352
Abdominal rigidity	21.38	11.65	14	31811	2707	70893912
Nasal disorder	21.16	11.65	15	31810	3299	70893320
Idiopathic orbital inflammation	21.05	11.65	6	31819	143	70896476
Neuropsychiatric symptoms	20.97	11.65	10	31815	1046	70895573
Somnambulism	20.93	11.65	18	31807	5242	70891377
Genital pain	20.91	11.65	8	31817	486	70896133
Irritability	20.67	11.65	50	31775	38175	70858444
Disease progression	20.54	11.65	24	31801	156648	70739971
Migraine	20.36	11.65	75	31750	72163	70824456
Arterial spasm	20.27	11.65	6	31819	164	70896455
Suicidal ideation	20.24	11.65	73	31752	69523	70827096
Hyponatraemia	20.21	11.65	132	31693	159955	70736664
Daydreaming	19.87	11.65	9	31816	837	70895782
Headache	19.85	11.65	368	31457	580037	70316582
Sleep disorder due to a general medical condition	19.84	11.65	24	31801	10452	70886167
Mood swings	19.77	11.65	32	31793	18254	70878365
Chorea	19.59	11.65	12	31813	2066	70894553
Ejaculation failure	19.51	11.65	7	31818	355	70896264
Acquired macroglossia	18.93	11.65	6	31819	207	70896412
Gastroenteritis aeromonas	18.93	11.65	4	31821	25	70896594
Muscle spasms	18.83	11.65	126	31699	153920	70742699
Cervicogenic headache	18.79	11.65	4	31821	26	70896593
Liver function test abnormal	18.52	11.65	65	31760	61081	70835538
Product administered to patient of inappropriate age	18.12	11.65	16	31809	4827	70891792
Spleen congestion	18.10	11.65	7	31818	438	70896181
Differential white blood cell count abnormal	18.05	11.65	11	31814	1877	70894742
Superinfection	17.98	11.65	15	31810	4191	70892428
Impaired quality of life	17.83	11.65	21	31804	8895	70887724
Skin exfoliation	17.69	11.65	55	31770	48571	70848048
Systemic lupus erythematosus	17.69	11.65	12	31813	101890	70794729
Illness	17.63	11.65	42	31783	31749	70864870
Neuropsychiatric syndrome	17.55	11.65	5	31820	119	70896500
Drug intolerance	17.48	11.65	48	31777	225639	70670980
Eye movement disorder	17.38	11.65	19	31806	7421	70889198
Secretion discharge	17.32	11.65	25	31800	12908	70883711
Renal failure	17.17	11.65	37	31788	189033	70707586
Upper gastrointestinal haemorrhage	17.12	11.65	46	31779	37431	70859188
Tongue pruritus	17.11	11.65	7	31818	508	70896111
Nasal discharge discolouration	17.07	11.65	11	31814	2070	70894549
Pulmonary congestion	17.05	11.65	36	31789	25118	70871501
Central obesity	17.04	11.65	10	31815	1593	70895026
Vaginal discharge	16.98	11.65	15	31810	4528	70892091
Musculoskeletal stiffness	16.94	11.65	25	31800	147735	70748884
Psychomotor hyperactivity	16.67	11.65	27	31798	15406	70881213
Gastrointestinal tract irritation	16.54	11.65	7	31818	553	70896066
Oral mucosal blistering	16.24	11.65	16	31809	5540	70891079
Infection	16.19	11.65	45	31780	210740	70685879
Joint swelling	16	11.65	59	31766	253152	70643467
Encephalopathy	15.94	11.65	4	31821	61657	70834962
Syncope	15.93	11.65	128	31697	165581	70731038
Chronic obstructive pulmonary disease	15.86	11.65	73	31752	77568	70819051
Multifocal motor neuropathy	15.59	11.65	4	31821	63	70896556
Overdose	15.59	11.65	33	31792	169712	70726907
Butterfly rash	15.41	11.65	9	31816	1421	70895198
Rhinovirus infection	15.39	11.65	17	31808	6716	70889903
Tendonitis	15.39	11.65	32	31793	22090	70874529
Lactic acidosis	15.37	11.65	5	31820	65019	70831600
Status asthmaticus	15.34	11.65	8	31817	1013	70895606
Graft versus host disease in gastrointestinal tract	15.34	11.65	16	31809	5928	70890691
Glossodynia	15.26	11.65	10	31815	86477	70810142
Benign prostatic hyperplasia	15.19	11.65	21	31804	10422	70886197
Nasal congestion	15.13	11.65	64	31761	65608	70831011
Eye swelling	15.09	11.65	33	31792	23581	70873038
Genital ulceration	15.05	11.65	7	31818	692	70895927
Plasma cell myeloma	15.03	11.65	7	31818	73194	70823425
Blood pressure fluctuation	14.93	11.65	4	31821	59008	70837611
Urinary incontinence	14.89	11.65	44	31781	37798	70858821
Ageusia	14.71	11.65	25	31800	14837	70881782
Therapeutic product effect decreased	14.70	11.65	26	31799	142992	70753627
Bronchomalacia	14.68	11.65	5	31820	217	70896402
Vascular device infection	14.56	11.65	18	31807	8012	70888607
Bronchitis	14.38	11.65	96	31729	117147	70779472
Bladder irritation	14.34	11.65	5	31820	233	70896386
Intentional product misuse	14.32	11.65	9	31816	79586	70817033
Suicide attempt	14.29	11.65	9	31816	79501	70817118
Facial pain	14.20	11.65	18	31807	8218	70888401
Eosinophilia	14.11	11.65	45	31780	40274	70856345
White blood cell count decreased	14.07	11.65	35	31790	170106	70726513
Discomfort	13.98	11.65	16	31809	105420	70791199
Abnormal weight gain	13.72	11.65	10	31815	2296	70894323
Oral mucosa erosion	13.67	11.65	9	31816	1756	70894863
Nasal septum ulceration	13.66	11.65	3	31822	23	70896596
Helicobacter infection	13.65	11.65	4	31821	55652	70840967
Reading disorder	13.63	11.65	7	31818	859	70895760
Skin fragility	13.63	11.65	7	31818	859	70895760
Oral pain	13.60	11.65	36	31789	29030	70867589
Abdominal discomfort	13.57	11.65	50	31775	214608	70682011
Dyspnoea at rest	13.53	11.65	16	31809	6803	70889816
Respiration abnormal	13.45	11.65	16	31809	6848	70889771
Hypovolaemia	13.39	11.65	25	31800	15968	70880651
Reperfusion arrhythmia	13.34	11.65	5	31820	287	70896332
Convulsive threshold lowered	13.20	11.65	7	31818	917	70895702
Intentional product use issue	13.13	11.65	21	31804	120121	70776498
Pneumonia streptococcal	13.06	11.65	10	31815	2473	70894146
Sleep disorder	13.04	11.65	64	31761	69808	70826811
Pulmonary oedema	13.03	11.65	72	31753	82206	70814413
Blood creatinine increased	12.97	11.65	28	31797	142973	70753646
Lacrimation increased	12.94	11.65	28	31797	19871	70876748
Insomnia	12.91	11.65	152	31673	217654	70678965
Mood altered	12.86	11.65	25	31800	16450	70880169
Beta haemolytic streptococcal infection	12.78	11.65	9	31816	1958	70894661
Sputum retention	12.76	11.65	7	31818	981	70895638
Necrosis ischaemic	12.66	11.65	7	31818	997	70895622
Gastric ulcer perforation	12.62	11.65	9	31816	1998	70894621
Platelet count increased	12.58	11.65	28	31797	20245	70876374
Cardio-respiratory arrest	12.58	11.65	16	31809	100661	70795958
Self-injurious ideation	12.43	11.65	11	31814	3327	70893292
Locked-in syndrome	12.39	11.65	6	31819	649	70895970
Hypotension	12.31	11.65	119	31706	404262	70492357
Derealisation	12.30	11.65	8	31817	1528	70895091
Sedation	12.14	11.65	3	31822	46728	70849891
Gastric mucosa erythema	12.13	11.65	5	31820	370	70896249
Violence-related symptom	11.92	11.65	6	31819	706	70895913
Multiple organ dysfunction syndrome	11.82	11.65	19	31806	108496	70788123
Contusion	11.81	11.65	98	31727	127938	70768681
Stomatitis	11.79	11.65	25	31800	128486	70768133
Inflammatory myofibroblastic tumour	11.74	11.65	4	31821	174	70896445

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A07EA07	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally
ATC	D07AC15	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III)
ATC	D07CC04	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, potent, combinations with antibiotics
ATC	R01AD01	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids
ATC	R03AK08	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC	R03AK13	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC	R03AL09	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC	R03BA01	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:49167	anti-asthmatic drugs
CHEBI has role	CHEBI:38070	antiarrhythmic agent
CHEBI has role	CHEBI:50266	Prodrugs
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D018373	Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vasomotor rhinitis	indication	8229003	DOID:4730
Nasal polyp	indication	52756005
Allergic rhinitis	indication	61582004
Rhinitis	indication	70076002	DOID:4483
Asthma	indication	195967001	DOID:2841
Asthma management	indication	406162001
Severe chronic obstructive pulmonary disease	off-label use	313299006
Mycosis	contraindication	3218000	DOID:1564
Ocular hypertension	contraindication	4210003	DOID:9282
Inactive tuberculosis	contraindication	11999007
Epistaxis	contraindication	12441001
Measles	contraindication	14189004	DOID:8622
Disease caused by parasite	contraindication	17322007
Glaucoma	contraindication	23986001	DOID:1686
Acute tuberculosis	contraindication	25629007
Perforation of nasal septum	contraindication	80142000
Bacterial infectious disease	contraindication	87628006
Mycobacteriosis	contraindication	88415009
Operation on nose	contraindication	88733004
Bilateral cataracts	contraindication	95722004
Ophthalmic herpes simplex	contraindication	186542001
Disease of liver	contraindication	235856003	DOID:409
Varicella-zoster virus infection	contraindication	309465005
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Exposure to varicella	contraindication	444453009
Nasal Trauma	contraindication
Nasal Candidiasis	contraindication
Nasal Septal Ulcers	contraindication
Uncontrolled Bacterial Infections	contraindication
Untreated Fungal Infection	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.01	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	Ki	8.43	DRUG MATRIX	CHEMBL
Interleukin-5	Cytokine	P05113	IL5_HUMAN		IC50	4.57	CHEMBL
Mineralocorticoid receptor	Nuclear hormone receptor	P08235	MCR_HUMAN		EC50	8.32	CHEMBL
Matrix metalloproteinase-9	Enzyme	P14780	MMP9_HUMAN		IC50	5.70	CHEMBL
Probable G-protein coupled receptor 97	GPCR	Q86Y34	AGRG3_HUMAN	AGONIST	EC50	8.50	IUPHAR
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN		IC50	7.55	CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		Ki	5.96	CHEMBL
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	7.57	CHEMBL
Glucocorticoid receptor	Transcription factor		GCR_RAT		IC50	8.54	CHEMBL
Interleukin-5	Unclassified		IL5_MOUSE		IC50	4.58	CHEMBL
Interleukin-5 receptor subunit alpha	Unclassified		IL5RA_MOUSE		IC50	4.58	CHEMBL

External reference:

ID	Source
D00689	KEGG_DRUG
1347	RXNORM
4018793	VANDF
4019625	VANDF
C0004906	UMLSCUI
CHEBI:3002	CHEBI
CHEBI:3001	CHEBI
CHEMBL1200500	ChEMBL_ID
CHEMBL1370	ChEMBL_ID
DB00394	DRUGBANK_ID
5894	IUPHAR_LIGAND_ID
7059	IUPHAR_LIGAND_ID
77011-63-3	SECONDARY_CAS_RN
21700	PUBCHEM_CID
1167	MMSL
4249	MMSL
71834	MMSL
8263	MMSL
d00760	MMSL
002179	NDDF
004947	NDDF
116574000	SNOMEDCT_US
116575004	SNOMEDCT_US
1389007	SNOMEDCT_US
426017007	SNOMEDCT_US
D019819	MESH_DESCRIPTOR_UI
D001507	MESH_DESCRIPTOR_UI
C0004905	UMLSCUI
2307	INN_ID
4419-39-0	SECONDARY_CAS_RN
20469	PUBCHEM_CID
5B307S63B2	UNII
KGZ1SLC28Z	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BECONASEAQ	HUMAN PRESCRIPTION DRUG LABEL	1	0173-0388	SPRAY, SUSPENSION	42 ug	NASAL	NDA	20 sections
BECONASEAQ	HUMAN PRESCRIPTION DRUG LABEL	1	0173-0388	SPRAY, SUSPENSION	42 ug	NASAL	NDA	20 sections
BECONASE AQ	HUMAN PRESCRIPTION DRUG LABEL	1	16590-030	SPRAY, SUSPENSION	42 ug	NASAL	NDA	13 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	16590-860	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	26 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1342	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	28 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3033	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	28 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3459	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	16 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	50090-5031	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	50090-5032	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	53002-2436	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	16 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	53002-3477	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	16 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5857	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	14 sections
QVAR	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5858	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	14 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-302	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-302	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-302	AEROSOL, METERED	40 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-304	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-304	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QVAR REDIHALER	HUMAN PRESCRIPTION DRUG LABEL	1	59310-304	AEROSOL, METERED	80 ug	RESPIRATORY (INHALATION)	NDA	17 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-406	AEROSOL, METERED	40 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-406	AEROSOL, METERED	40 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-406	AEROSOL, METERED	40 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-410	AEROSOL, METERED	80 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-410	AEROSOL, METERED	80 ug	NASAL	NDA	27 sections
QNASL	HUMAN PRESCRIPTION DRUG LABEL	1	59310-410	AEROSOL, METERED	80 ug	NASAL	NDA	27 sections