beclometasone dipropionate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 294 5534-09-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rhinocort
  • beclometasone dipropionate
  • beclomethasone dipropionate
  • beclomethasone dipropionate monohydrate
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
  • Molecular weight: 521.05
  • Formula: C28H37ClO7
  • CLOGP: 4.26
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.40
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 mg N
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
1.50 mg Inhal.solution

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.05 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.29 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 36 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.13 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 12, 1976 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 510.78 12.62 402 23042 112368 56156255
Wheezing 181.15 12.62 188 23256 74838 56193785
Rheumatoid arthritis 119.41 12.62 11 23433 382593 55886030
Dyspnoea 95.54 12.62 492 22952 592085 55676538
Depressed mood 85.67 12.62 90 23354 36269 56232354
Drug ineffective 83.38 12.62 161 23283 918828 55349795
Nightmare 80.24 12.62 62 23382 16764 56251859
Chest discomfort 80.22 12.62 146 23298 98711 56169912
Cough 80.11 12.62 264 23180 259697 56008926
Lip swelling 69.08 12.62 69 23375 26203 56242420
Swelling face 67.48 12.62 99 23345 55970 56212653
Bronchospasm 66.69 12.62 54 23390 15615 56253008
Swollen tongue 59.17 12.62 68 23376 30256 56238367
Contraindicated product administered 56.34 12.62 6 23438 186280 56082343
Arthropathy 50.24 12.62 11 23433 200264 56068359
Treatment failure 50.23 12.62 6 23438 170386 56098237
Infusion related reaction 49.42 12.62 13 23431 208918 56059705
Transient ischaemic attack 45.87 12.62 63 23381 33514 56235109
Asthmatic crisis 44.11 12.62 19 23425 1691 56266932
Aggression 44.03 12.62 50 23394 21956 56246667
Separation anxiety disorder 43.19 12.62 8 23436 24 56268599
Blood electrolytes abnormal 43.02 12.62 16 23428 970 56267653
Toxicity to various agents 42.79 12.62 20 23424 224544 56044079
Bronchial secretion retention 42.50 12.62 19 23425 1849 56266774
Death 42.26 12.62 48 23396 341378 55927245
Malaise 41.19 12.62 278 23166 367582 55901041
Bacterial disease carrier 40.41 12.62 15 23429 904 56267719
Sputum discoloured 40.29 12.62 39 23405 14253 56254370
Throat tightness 36.74 12.62 46 23398 22361 56246262
Flashback 36.16 12.62 9 23435 135 56268488
Nonspecific reaction 36.10 12.62 17 23427 1864 56266759
Systemic lupus erythematosus 35.93 12.62 15 23429 180063 56088560
Periorbital swelling 35.93 12.62 18 23426 2260 56266363
Off label use 35.70 12.62 116 23328 556064 55712559
Glossodynia 35.07 12.62 10 23434 152448 56116175
Productive cough 34.61 12.62 74 23370 56158 56212465
Pericarditis 34.25 12.62 3 23441 108920 56159703
Squamous cell carcinoma of the oral cavity 33.69 12.62 10 23434 298 56268325
Abdominal discomfort 33.19 12.62 40 23404 277234 55991389
Middle insomnia 32.99 12.62 31 23413 10919 56257704
Eosinophilic granulomatosis with polyangiitis 31.67 12.62 16 23428 2045 56266578
Anaphylactic reaction 31.11 12.62 73 23371 58922 56209701
Paraesthesia oral 30.91 12.62 34 23410 14415 56254208
Obstructive airways disorder 30.79 12.62 37 23407 17245 56251378
Dizziness 30.69 12.62 264 23180 375876 55892747
Infective pulmonary exacerbation of cystic fibrosis 30.32 12.62 26 23418 8131 56260492
Oropharyngeal pain 30.23 12.62 90 23354 83698 56184925
Anxiety 29.90 12.62 159 23285 193013 56075610
Breast conserving surgery 29.68 12.62 12 23432 911 56267712
Palpitations 29.51 12.62 100 23344 99572 56169051
Gastric mucosa erythema 29.33 12.62 9 23435 301 56268322
Miller Fisher syndrome 29.27 12.62 7 23437 88 56268535
Limb injury 29.23 12.62 41 23403 22229 56246394
Angioplasty 28.56 12.62 13 23431 1319 56267304
Bronchitis 28.39 12.62 107 23337 112204 56156419
Sinusitis 28.15 12.62 159 23285 197422 56071201
Drug monitoring procedure not performed 28.14 12.62 10 23434 532 56268091
Therapeutic product effect decreased 28.04 12.62 18 23426 169434 56099189
Superinfection 27.93 12.62 15 23429 2173 56266450
Abdominal rigidity 27.85 12.62 14 23430 1771 56266852
Hepatic enzyme increased 27.29 12.62 19 23425 171365 56097258
Hiccups 26.42 12.62 14 23430 1974 56266649
Discomfort 26.41 12.62 13 23431 141748 56126875
Arterial spasm 26.34 12.62 6 23438 60 56268563
Pharyngeal swelling 26.27 12.62 20 23424 5286 56263337
Sleep disorder due to a general medical condition 25.99 12.62 25 23419 9065 56259558
Rash macular 25.67 12.62 37 23407 20567 56248056
Differential white blood cell count abnormal 25.21 12.62 10 23434 722 56267901
Essential tremor 25.19 12.62 11 23433 1012 56267611
Dysmetropsia 25.12 12.62 6 23438 75 56268548
Drug intolerance 25.04 12.62 45 23399 264773 56003850
Peripheral vascular disorder 24.93 12.62 20 23424 5705 56262918
Choking 24.33 12.62 24 23420 8973 56259650
Nail infection 24.21 12.62 14 23430 2339 56266284
Forced expiratory volume decreased 24.04 12.62 18 23426 4642 56263981
Eye movement disorder 23.60 12.62 18 23426 4771 56263852
Genital pain 23.50 12.62 8 23436 374 56268249
Dermatitis allergic 23.40 12.62 29 23415 13949 56254674
Alopecia 23.40 12.62 55 23389 293403 55975220
Hyponatraemia 23.13 12.62 94 23350 102045 56166578
Musculoskeletal stiffness 22.66 12.62 19 23425 155988 56112635
Idiopathic orbital inflammation 22.30 12.62 6 23438 124 56268499
Pregnancy with implant contraceptive 22.03 12.62 13 23431 2255 56266368
Myalgia 22.03 12.62 111 23333 131914 56136709
Vascular device infection 21.15 12.62 18 23426 5572 56263051
Helicobacter infection 20.57 12.62 3 23441 73265 56195358
Lacrimation increased 20.07 12.62 31 23413 18317 56250306
Status asthmaticus 19.90 12.62 9 23435 900 56267723
Gingival swelling 19.62 12.62 15 23429 3991 56264632
Joint swelling 19.55 12.62 59 23385 289741 55978882
Facial pain 19.48 12.62 20 23424 7838 56260785
Secretion discharge 19.48 12.62 23 23421 10523 56258100
Gastroenteritis aeromonas 19.22 12.62 4 23440 25 56268598
Anger 19.19 12.62 24 23420 11648 56256975
Poor peripheral circulation 19.07 12.62 14 23430 3503 56265120
Duodenal ulcer perforation 18.73 12.62 3 23441 68339 56200284
Illness 18.51 12.62 43 23401 34468 56234155
Pain 18.48 12.62 182 23262 663002 55605621
Urticaria 18.37 12.62 113 23331 144563 56124060
Oral mucosal blistering 18.35 12.62 16 23428 5118 56263505
Butterfly rash 18.32 12.62 10 23434 1496 56267127
Tongue pruritus 18.04 12.62 7 23437 477 56268146
Sinus operation 17.98 12.62 11 23433 2037 56266586
Genital ulceration 17.81 12.62 7 23437 493 56268130
Rhinovirus infection 17.71 12.62 14 23430 3908 56264715
Hyperkinesia 17.53 12.62 10 23434 1629 56266994
Brain contusion 17.08 12.62 7 23437 550 56268073
Nasal discomfort 17.07 12.62 14 23430 4118 56264505
Respiration abnormal 17.05 12.62 16 23428 5625 56262998
Migraine 16.66 12.62 76 23368 86721 56181902
Malignant neoplasm progression 16.60 12.62 5 23439 73582 56195041
Drug abuse 16.36 12.62 4 23440 67606 56201017
Angioedema 16.36 12.62 46 23398 41407 56227216
Tendonitis 16.29 12.62 28 23416 18069 56250554
Vaginal discharge 15.85 12.62 16 23428 6147 56262476
Antipsychotic drug level increased 15.57 12.62 12 23432 3230 56265393
Derealisation 15.47 12.62 8 23436 1073 56267550
Acute myocardial infarction 15.36 12.62 37 23407 30356 56238267
Oral mucosa erosion 15.34 12.62 8 23436 1092 56267531
Bladder irritation 15.13 12.62 5 23439 213 56268410
Urinary incontinence 14.93 12.62 36 23408 29549 56239074
Stomatitis 14.89 12.62 17 23427 120793 56147830
Pulmonary oedema 14.85 12.62 51 23393 51092 56217531
Maternal exposure during pregnancy 14.72 12.62 36 23408 189517 56079106
Reperfusion arrhythmia 14.68 12.62 5 23439 234 56268389
Pneumonia streptococcal 14.65 12.62 9 23435 1679 56266944
Skin exfoliation 14.62 12.62 41 23403 36859 56231764
Pulmonary congestion 14.60 12.62 25 23419 16090 56252533
Blood cholesterol increased 14.54 12.62 6 23438 72573 56196050
Cytomegalovirus enteritis 14.52 12.62 5 23439 242 56268381
Necrosis ischaemic 14.49 12.62 7 23437 812 56267811
Crepitations 14.19 12.62 16 23428 6968 56261655
Product dosage form issue 13.77 12.62 3 23441 24 56268599
Impaired healing 13.33 12.62 10 23434 86831 56181792
Impaired quality of life 13.26 12.62 17 23427 8457 56260166
Mobility decreased 13.24 12.62 13 23431 98978 56169645
Anaemia 13.13 12.62 62 23382 267449 56001174
Platelet count decreased 13.08 12.62 15 23429 106368 56162255
Skin fragility 12.91 12.62 6 23438 639 56267984
Febrile neutropenia 12.85 12.62 15 23429 105530 56163093
Abnormal behaviour 12.84 12.62 27 23417 20245 56248378

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 351.87 13.37 222 13393 42389 31641340
Wheezing 135.66 13.37 117 13498 35869 31647860
Dyspnoea 84.44 13.37 330 13285 343149 31340580
Sleep terror 75.30 13.37 23 13592 734 31682995
Lip swelling 64.17 13.37 50 13565 13273 31670456
Anger 62.91 13.37 46 13569 11107 31672622
Ballismus 60.61 13.37 12 13603 54 31683675
Nightmare 55.12 13.37 44 13571 12093 31671636
Swollen tongue 50.81 13.37 43 13572 12819 31670910
Blood immunoglobulin E increased 47.92 13.37 22 13593 2209 31681520
Lower respiratory tract infection 43.41 13.37 57 13558 28180 31655549
Pharyngeal oedema 42.28 13.37 28 13587 5768 31677961
Abnormal behaviour 41.20 13.37 51 13564 23777 31659952
Infective pulmonary exacerbation of cystic fibrosis 39.43 13.37 28 13587 6456 31677273
Malaise 37.21 13.37 157 13458 168354 31515375
Attention-seeking behaviour 33.96 13.37 7 13608 40 31683689
Nasal disorder 33.82 13.37 16 13599 1719 31682010
Acquired macroglossia 32.21 13.37 6 13609 18 31683711
Anosmia 30.86 13.37 16 13599 2092 31681637
Chorea 28.39 13.37 12 13603 988 31682741
Neuropsychiatric symptoms 28.17 13.37 10 13605 514 31683215
Chest discomfort 27.97 13.37 64 13551 49305 31634424
Cough 27.73 13.37 123 13492 134691 31549038
Chronic obstructive pulmonary disease 26.08 13.37 59 13556 45107 31638622
Crepitations 25.96 13.37 16 13599 2912 31680817
Toxicity to various agents 25.79 13.37 24 13591 181463 31502266
Dyspnoea at rest 25.61 13.37 17 13598 3514 31680215
Sputum discoloured 25.42 13.37 22 13593 6754 31676975
Neonatal hyponatraemia 25.09 13.37 6 13609 73 31683656
Death 25.00 13.37 76 13539 360493 31323236
Central obesity 24.82 13.37 9 13606 492 31683237
Daydreaming 24.54 13.37 9 13606 508 31683221
Nasal discomfort 23.44 13.37 12 13603 1528 31682201
Gastrointestinal tract irritation 22.72 13.37 7 13608 230 31683499
Crying 22.69 13.37 19 13596 5578 31678151
Paraesthesia oral 22.52 13.37 16 13599 3692 31680037
Gastric ulcer perforation 22.01 13.37 10 13605 980 31682749
Productive cough 21.85 13.37 46 13569 33494 31650235
Depressed mood 21.79 13.37 32 13583 17543 31666186
Neuropsychiatric syndrome 20.97 13.37 5 13610 60 31683669
Spleen congestion 20.89 13.37 7 13608 302 31683427
Cervicogenic headache 20.79 13.37 4 13611 15 31683714
Completed suicide 20.27 13.37 7 13608 91507 31592222
Micturition urgency 20.20 13.37 18 13597 5742 31677987
Malignant neoplasm progression 19.39 13.37 5 13610 78993 31604736
Bronchomalacia 19.19 13.37 5 13610 88 31683641
Sinusitis 19.06 13.37 46 13569 36650 31647079
Platelet count decreased 18.99 13.37 12 13603 110423 31573306
Mesothelioma 18.71 13.37 7 13608 418 31683311
Palpitations 18.67 13.37 44 13571 34539 31649190
Mood swings 18.11 13.37 19 13596 7405 31676324
Eye swelling 18.09 13.37 21 13594 9155 31674574
Locked-in syndrome 17.93 13.37 6 13609 258 31683471
Self-injurious ideation 17.54 13.37 10 13605 1577 31682152
Nasal septum perforation 17.53 13.37 5 13610 125 31683604
Convulsive threshold lowered 17.41 13.37 7 13608 508 31683221
Suicidal ideation 17.19 13.37 44 13571 36362 31647367
Multifocal motor neuropathy 16.85 13.37 4 13611 47 31683682
Graft versus host disease in gastrointestinal tract 16.62 13.37 13 13602 3466 31680263
Off label use 16.51 13.37 85 13530 347189 31336540
Benign prostatic hyperplasia 16.42 13.37 24 13591 13101 31670628
Angioedema 16.25 13.37 41 13574 33577 31650152
Apnoeic attack 16.24 13.37 6 13609 346 31683383
Rash papular 16.20 13.37 19 13596 8373 31675356
Ocular discomfort 15.96 13.37 10 13605 1873 31681856
Aortic dissection 15.58 13.37 11 13604 2511 31681218
Cystic fibrosis 15.56 13.37 10 13605 1956 31681773
Urticaria 15.40 13.37 57 13558 57460 31626269
Renal aplasia 15.32 13.37 7 13608 695 31683034
Antibody test abnormal 15.26 13.37 5 13610 201 31683528
Tryptase increased 15.07 13.37 5 13610 209 31683520
Headache 14.95 13.37 132 13483 183520 31500209
Thrombocytopenia 14.86 13.37 24 13591 142723 31541006
Sleep disorder 14.74 13.37 34 13581 26314 31657415
Ejaculation failure 14.69 13.37 7 13608 764 31682965
Ageusia 14.58 13.37 19 13596 9312 31674417
Renal failure 14.54 13.37 19 13596 123311 31560418
Nasal inflammation 14.49 13.37 5 13610 236 31683493
Weaning failure 14.49 13.37 5 13610 236 31683493
Sleep talking 14.44 13.37 6 13609 473 31683256
Neonatal seizure 14.38 13.37 6 13609 478 31683251
Product administered to patient of inappropriate age 14.36 13.37 11 13604 2846 31680883
Anaphylactic reaction 14.24 13.37 36 13579 29517 31654212
Obstructive airways disorder 14.19 13.37 22 13593 12642 31671087
Abdominal symptom 14.12 13.37 6 13609 501 31683228
Eosinophilia 14.12 13.37 31 13584 23222 31660507
Insomnia 14.12 13.37 79 13536 94757 31588972
Hepatic cancer 14.01 13.37 17 13598 7758 31675971
Reading disorder 13.96 13.37 6 13609 515 31683214
Violence-related symptom 13.95 13.37 6 13609 516 31683213
Oral pain 13.91 13.37 19 13596 9746 31673983

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 681.77 11.65 506 31319 120287 70776332
Wheezing 266.43 11.65 266 31559 93904 70802715
Dyspnoea 148.99 11.65 710 31115 769350 70127269
Nightmare 145.56 11.65 102 31723 22054 70874565
Lip swelling 132.55 11.65 115 31710 33939 70862680
Depressed mood 113.27 11.65 118 31707 43702 70852917
Swollen tongue 108.99 11.65 107 31718 36939 70859680
Rheumatoid arthritis 92.91 11.65 11 31814 291794 70604825
Chest discomfort 85.66 11.65 179 31646 124202 70772417
Sleep terror 82.85 11.65 28 31797 1187 70895432
Completed suicide 79.06 11.65 6 31819 227129 70669490
Drug ineffective 75.55 11.65 197 31628 939555 69957064
Anger 74.18 11.65 60 31765 16072 70880547
Swelling face 73.13 11.65 114 31711 63050 70833569
Malaise 71.83 11.65 383 31442 432549 70464070
Toxicity to various agents 69.26 11.65 43 31782 382129 70514490
Cough 65.36 11.65 304 31521 325073 70571546
Infective pulmonary exacerbation of cystic fibrosis 64.05 11.65 49 31776 12109 70884510
Sputum discoloured 62.16 11.65 58 31767 18793 70877826
Death 59.01 11.65 86 31739 509975 70386644
Bronchospasm 58.21 11.65 61 31764 22731 70873888
Abnormal behaviour 55.40 11.65 73 31752 34636 70861983
Infusion related reaction 48.88 11.65 14 31811 197520 70699099
Dizziness 48.46 11.65 365 31460 463776 70432843
Drug abuse 48.23 11.65 5 31820 147251 70749368
Paraesthesia oral 48.09 11.65 46 31779 15371 70881248
Separation anxiety disorder 47.92 11.65 9 31816 27 70896592
Palpitations 46.75 11.65 132 31693 110621 70785998
Ballismus 46.49 11.65 12 31813 194 70896425
Off label use 46.00 11.65 175 31650 742885 70153734
Pharyngeal oedema 45.53 11.65 45 31780 15651 70880968
Treatment failure 44.46 11.65 6 31819 144136 70752483
Productive cough 44.04 11.65 104 31721 78233 70818386
Synovitis 43.33 11.65 4 31821 129224 70767395
Transient ischaemic attack 42.52 11.65 75 31750 45869 70850750
Asthmatic crisis 40.99 11.65 19 31806 1865 70894754
Contraindicated product administered 40.59 11.65 6 31819 134606 70762013
Bacterial disease carrier 40.31 11.65 16 31809 1073 70895546
Crepitations 39.19 11.65 32 31793 8682 70887937
Aggression 38.43 11.65 74 31751 48372 70848247
Arthropathy 38.31 11.65 10 31815 150047 70746572
Periorbital swelling 37.94 11.65 19 31806 2211 70894408
Obstructive airways disorder 37.23 11.65 52 31773 26061 70870558
Malignant neoplasm progression 35.41 11.65 6 31819 121733 70774886
Myalgia 34.47 11.65 158 31667 167734 70728885
Eosinophilic granulomatosis with polyangiitis 34.05 11.65 20 31805 3193 70893426
Anxiety 33.78 11.65 191 31634 220139 70676480
Essential tremor 32.75 11.65 15 31810 1432 70895187
Bronchial secretion retention 32.59 11.65 19 31806 2991 70893628
Breast conserving surgery 32.51 11.65 12 31813 660 70895959
Blood electrolytes abnormal 32.47 11.65 16 31809 1798 70894821
Oropharyngeal pain 32.39 11.65 106 31719 96204 70800415
Attention-seeking behaviour 32.33 11.65 8 31817 108 70896511
Pharyngeal swelling 31.80 11.65 25 31800 6428 70890191
Throat tightness 31.54 11.65 47 31778 24975 70871644
Blood immunoglobulin E increased 31.52 11.65 22 31803 4722 70891897
Middle insomnia 31.31 11.65 35 31790 14018 70882601
Rash macular 30.81 11.65 47 31778 25497 70871122
Choking 30.77 11.65 31 31794 11029 70885590
Angioedema 30.69 11.65 82 31743 66528 70830091
Nonspecific reaction 30.22 11.65 16 31809 2089 70894530
Crying 29.90 11.65 42 31783 21157 70875462
Hepatic enzyme increased 29.32 11.65 17 31808 156973 70739646
Forced expiratory volume decreased 29.05 11.65 25 31800 7289 70889330
Anosmia 28.66 11.65 21 31804 4862 70891757
Dermatitis allergic 28.47 11.65 36 31789 16395 70880224
Anaphylactic reaction 28.41 11.65 86 31739 74888 70821731
Squamous cell carcinoma of the oral cavity 28.16 11.65 10 31815 492 70896127
Urticaria 28.13 11.65 146 31679 162903 70733716
Gingival swelling 27.09 11.65 19 31806 4110 70892509
Thrombocytopenia 26.92 11.65 41 31784 239069 70657550
Angioplasty 26.75 11.65 14 31811 1786 70894833
Antipsychotic drug level increased 26.64 11.65 21 31804 5419 70891200
Limb injury 26.40 11.65 44 31781 25708 70870911
Pregnancy with implant contraceptive 25.30 11.65 13 31812 1596 70895023
Platelet count decreased 24.80 11.65 26 31799 178196 70718423
Nail infection 24.17 11.65 14 31811 2177 70894442
Disturbance in attention 24.16 11.65 57 31768 42837 70853782
Dysmetropsia 23.98 11.65 6 31819 85 70896534
Miller Fisher syndrome 23.76 11.65 7 31818 188 70896431
Pain 23.74 11.65 175 31650 628641 70267978
Micturition urgency 23.21 11.65 27 31798 11287 70885332
Pericarditis 22.88 11.65 5 31820 84700 70811919
Poor peripheral circulation 22.78 11.65 16 31809 3469 70893150
Sinus operation 22.73 11.65 13 31812 1974 70894645
Drug monitoring procedure not performed 22.54 11.65 10 31815 886 70895733
Bleeding time prolonged 22.49 11.65 11 31814 1217 70895402
Peripheral vascular disorder 22.35 11.65 22 31803 7610 70889009
Hallucination 22.19 11.65 80 31745 76180 70820439
Febrile neutropenia 22.07 11.65 36 31789 204282 70692337
Anaemia 21.78 11.65 100 31725 403323 70493296
Flashback 21.42 11.65 7 31818 267 70896352
Abdominal rigidity 21.38 11.65 14 31811 2707 70893912
Nasal disorder 21.16 11.65 15 31810 3299 70893320
Idiopathic orbital inflammation 21.05 11.65 6 31819 143 70896476
Neuropsychiatric symptoms 20.97 11.65 10 31815 1046 70895573
Somnambulism 20.93 11.65 18 31807 5242 70891377
Genital pain 20.91 11.65 8 31817 486 70896133
Irritability 20.67 11.65 50 31775 38175 70858444
Disease progression 20.54 11.65 24 31801 156648 70739971
Migraine 20.36 11.65 75 31750 72163 70824456
Arterial spasm 20.27 11.65 6 31819 164 70896455
Suicidal ideation 20.24 11.65 73 31752 69523 70827096
Hyponatraemia 20.21 11.65 132 31693 159955 70736664
Daydreaming 19.87 11.65 9 31816 837 70895782
Headache 19.85 11.65 368 31457 580037 70316582
Sleep disorder due to a general medical condition 19.84 11.65 24 31801 10452 70886167
Mood swings 19.77 11.65 32 31793 18254 70878365
Chorea 19.59 11.65 12 31813 2066 70894553
Ejaculation failure 19.51 11.65 7 31818 355 70896264
Acquired macroglossia 18.93 11.65 6 31819 207 70896412
Gastroenteritis aeromonas 18.93 11.65 4 31821 25 70896594
Muscle spasms 18.83 11.65 126 31699 153920 70742699
Cervicogenic headache 18.79 11.65 4 31821 26 70896593
Liver function test abnormal 18.52 11.65 65 31760 61081 70835538
Product administered to patient of inappropriate age 18.12 11.65 16 31809 4827 70891792
Spleen congestion 18.10 11.65 7 31818 438 70896181
Differential white blood cell count abnormal 18.05 11.65 11 31814 1877 70894742
Superinfection 17.98 11.65 15 31810 4191 70892428
Impaired quality of life 17.83 11.65 21 31804 8895 70887724
Skin exfoliation 17.69 11.65 55 31770 48571 70848048
Systemic lupus erythematosus 17.69 11.65 12 31813 101890 70794729
Illness 17.63 11.65 42 31783 31749 70864870
Neuropsychiatric syndrome 17.55 11.65 5 31820 119 70896500
Drug intolerance 17.48 11.65 48 31777 225639 70670980
Eye movement disorder 17.38 11.65 19 31806 7421 70889198
Secretion discharge 17.32 11.65 25 31800 12908 70883711
Renal failure 17.17 11.65 37 31788 189033 70707586
Upper gastrointestinal haemorrhage 17.12 11.65 46 31779 37431 70859188
Tongue pruritus 17.11 11.65 7 31818 508 70896111
Nasal discharge discolouration 17.07 11.65 11 31814 2070 70894549
Pulmonary congestion 17.05 11.65 36 31789 25118 70871501
Central obesity 17.04 11.65 10 31815 1593 70895026
Vaginal discharge 16.98 11.65 15 31810 4528 70892091
Musculoskeletal stiffness 16.94 11.65 25 31800 147735 70748884
Psychomotor hyperactivity 16.67 11.65 27 31798 15406 70881213
Gastrointestinal tract irritation 16.54 11.65 7 31818 553 70896066
Oral mucosal blistering 16.24 11.65 16 31809 5540 70891079
Infection 16.19 11.65 45 31780 210740 70685879
Joint swelling 16 11.65 59 31766 253152 70643467
Encephalopathy 15.94 11.65 4 31821 61657 70834962
Syncope 15.93 11.65 128 31697 165581 70731038
Chronic obstructive pulmonary disease 15.86 11.65 73 31752 77568 70819051
Multifocal motor neuropathy 15.59 11.65 4 31821 63 70896556
Overdose 15.59 11.65 33 31792 169712 70726907
Butterfly rash 15.41 11.65 9 31816 1421 70895198
Rhinovirus infection 15.39 11.65 17 31808 6716 70889903
Tendonitis 15.39 11.65 32 31793 22090 70874529
Lactic acidosis 15.37 11.65 5 31820 65019 70831600
Status asthmaticus 15.34 11.65 8 31817 1013 70895606
Graft versus host disease in gastrointestinal tract 15.34 11.65 16 31809 5928 70890691
Glossodynia 15.26 11.65 10 31815 86477 70810142
Benign prostatic hyperplasia 15.19 11.65 21 31804 10422 70886197
Nasal congestion 15.13 11.65 64 31761 65608 70831011
Eye swelling 15.09 11.65 33 31792 23581 70873038
Genital ulceration 15.05 11.65 7 31818 692 70895927
Plasma cell myeloma 15.03 11.65 7 31818 73194 70823425
Blood pressure fluctuation 14.93 11.65 4 31821 59008 70837611
Urinary incontinence 14.89 11.65 44 31781 37798 70858821
Ageusia 14.71 11.65 25 31800 14837 70881782
Therapeutic product effect decreased 14.70 11.65 26 31799 142992 70753627
Bronchomalacia 14.68 11.65 5 31820 217 70896402
Vascular device infection 14.56 11.65 18 31807 8012 70888607
Bronchitis 14.38 11.65 96 31729 117147 70779472
Bladder irritation 14.34 11.65 5 31820 233 70896386
Intentional product misuse 14.32 11.65 9 31816 79586 70817033
Suicide attempt 14.29 11.65 9 31816 79501 70817118
Facial pain 14.20 11.65 18 31807 8218 70888401
Eosinophilia 14.11 11.65 45 31780 40274 70856345
White blood cell count decreased 14.07 11.65 35 31790 170106 70726513
Discomfort 13.98 11.65 16 31809 105420 70791199
Abnormal weight gain 13.72 11.65 10 31815 2296 70894323
Oral mucosa erosion 13.67 11.65 9 31816 1756 70894863
Nasal septum ulceration 13.66 11.65 3 31822 23 70896596
Helicobacter infection 13.65 11.65 4 31821 55652 70840967
Reading disorder 13.63 11.65 7 31818 859 70895760
Skin fragility 13.63 11.65 7 31818 859 70895760
Oral pain 13.60 11.65 36 31789 29030 70867589
Abdominal discomfort 13.57 11.65 50 31775 214608 70682011
Dyspnoea at rest 13.53 11.65 16 31809 6803 70889816
Respiration abnormal 13.45 11.65 16 31809 6848 70889771
Hypovolaemia 13.39 11.65 25 31800 15968 70880651
Reperfusion arrhythmia 13.34 11.65 5 31820 287 70896332
Convulsive threshold lowered 13.20 11.65 7 31818 917 70895702
Intentional product use issue 13.13 11.65 21 31804 120121 70776498
Pneumonia streptococcal 13.06 11.65 10 31815 2473 70894146
Sleep disorder 13.04 11.65 64 31761 69808 70826811
Pulmonary oedema 13.03 11.65 72 31753 82206 70814413
Blood creatinine increased 12.97 11.65 28 31797 142973 70753646
Lacrimation increased 12.94 11.65 28 31797 19871 70876748
Insomnia 12.91 11.65 152 31673 217654 70678965
Mood altered 12.86 11.65 25 31800 16450 70880169
Beta haemolytic streptococcal infection 12.78 11.65 9 31816 1958 70894661
Sputum retention 12.76 11.65 7 31818 981 70895638
Necrosis ischaemic 12.66 11.65 7 31818 997 70895622
Gastric ulcer perforation 12.62 11.65 9 31816 1998 70894621
Platelet count increased 12.58 11.65 28 31797 20245 70876374
Cardio-respiratory arrest 12.58 11.65 16 31809 100661 70795958
Self-injurious ideation 12.43 11.65 11 31814 3327 70893292
Locked-in syndrome 12.39 11.65 6 31819 649 70895970
Hypotension 12.31 11.65 119 31706 404262 70492357
Derealisation 12.30 11.65 8 31817 1528 70895091
Sedation 12.14 11.65 3 31822 46728 70849891
Gastric mucosa erythema 12.13 11.65 5 31820 370 70896249
Violence-related symptom 11.92 11.65 6 31819 706 70895913
Multiple organ dysfunction syndrome 11.82 11.65 19 31806 108496 70788123
Contusion 11.81 11.65 98 31727 127938 70768681
Stomatitis 11.79 11.65 25 31800 128486 70768133
Inflammatory myofibroblastic tumour 11.74 11.65 4 31821 174 70896445

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EA07 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC D07AC15 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07CC04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
ATC R01AD01 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03AK08 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL09 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03BA01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:50266 Prodrugs
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D019141 Respiratory System Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Nasal polyp indication 52756005
Allergic rhinitis indication 61582004
Rhinitis indication 70076002 DOID:4483
Asthma indication 195967001 DOID:2841
Asthma management indication 406162001
Severe chronic obstructive pulmonary disease off-label use 313299006
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Inactive tuberculosis contraindication 11999007
Epistaxis contraindication 12441001
Measles contraindication 14189004 DOID:8622
Disease caused by parasite contraindication 17322007
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Perforation of nasal septum contraindication 80142000
Bacterial infectious disease contraindication 87628006
Mycobacteriosis contraindication 88415009
Operation on nose contraindication 88733004
Bilateral cataracts contraindication 95722004
Ophthalmic herpes simplex contraindication 186542001
Disease of liver contraindication 235856003 DOID:409
Varicella-zoster virus infection contraindication 309465005
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Exposure to varicella contraindication 444453009
Nasal Trauma contraindication
Nasal Candidiasis contraindication
Nasal Septal Ulcers contraindication
Uncontrolled Bacterial Infections contraindication
Untreated Fungal Infection contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.01 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 8.43 DRUG MATRIX CHEMBL
Interleukin-5 Cytokine IC50 4.57 CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor EC50 8.32 CHEMBL
Matrix metalloproteinase-9 Enzyme IC50 5.70 CHEMBL
Probable G-protein coupled receptor 97 GPCR AGONIST EC50 8.50 IUPHAR
Progesterone receptor Nuclear hormone receptor IC50 7.55 CHEMBL
Androgen receptor Transcription factor Ki 5.96 CHEMBL
Progesterone receptor Transcription factor Ki 7.57 CHEMBL
Glucocorticoid receptor Transcription factor IC50 8.54 CHEMBL
Interleukin-5 Unclassified IC50 4.58 CHEMBL
Interleukin-5 receptor subunit alpha Unclassified IC50 4.58 CHEMBL

External reference:

IDSource
D00689 KEGG_DRUG
1347 RXNORM
4018793 VANDF
4019625 VANDF
C0004906 UMLSCUI
CHEBI:3002 CHEBI
CHEBI:3001 CHEBI
CHEMBL1200500 ChEMBL_ID
CHEMBL1370 ChEMBL_ID
DB00394 DRUGBANK_ID
5894 IUPHAR_LIGAND_ID
7059 IUPHAR_LIGAND_ID
77011-63-3 SECONDARY_CAS_RN
21700 PUBCHEM_CID
1167 MMSL
4249 MMSL
71834 MMSL
8263 MMSL
d00760 MMSL
002179 NDDF
004947 NDDF
116574000 SNOMEDCT_US
116575004 SNOMEDCT_US
1389007 SNOMEDCT_US
426017007 SNOMEDCT_US
D019819 MESH_DESCRIPTOR_UI
D001507 MESH_DESCRIPTOR_UI
C0004905 UMLSCUI
2307 INN_ID
4419-39-0 SECONDARY_CAS_RN
20469 PUBCHEM_CID
5B307S63B2 UNII
KGZ1SLC28Z UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BECONASEAQ HUMAN PRESCRIPTION DRUG LABEL 1 0173-0388 SPRAY, SUSPENSION 42 ug NASAL NDA 20 sections
BECONASEAQ HUMAN PRESCRIPTION DRUG LABEL 1 0173-0388 SPRAY, SUSPENSION 42 ug NASAL NDA 20 sections
BECONASE AQ HUMAN PRESCRIPTION DRUG LABEL 1 16590-030 SPRAY, SUSPENSION 42 ug NASAL NDA 13 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 16590-860 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 26 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 50090-1342 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 28 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 50090-3033 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 28 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 50090-3459 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 50090-5031 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 50090-5032 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 53002-2436 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 53002-3477 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 16 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 54868-5857 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 14 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 54868-5858 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 14 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-302 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-302 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-302 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-304 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-304 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-304 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 17 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-406 AEROSOL, METERED 40 ug NASAL NDA 27 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-406 AEROSOL, METERED 40 ug NASAL NDA 27 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-406 AEROSOL, METERED 40 ug NASAL NDA 27 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-410 AEROSOL, METERED 80 ug NASAL NDA 27 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-410 AEROSOL, METERED 80 ug NASAL NDA 27 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-410 AEROSOL, METERED 80 ug NASAL NDA 27 sections