Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	1312	70-18-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: glutathione GSH glutathion deltathione glutinal	A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. Molecular weight: 307.32 Formula: C10H17N3O6S CLOGP: -3.05 LIPINSKI: 0 HAC: 9 HDO: 5 TPSA: 158.82 ALOGS: -2.54 ROTB: 9 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

glutathione
GSH
glutathion
deltathione
glutinal

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Molecular weight: 307.32
Formula: C10H17N3O6S
CLOGP: -3.05
LIPINSKI: 0
HAC: 9
HDO: 5
TPSA: 158.82
ALOGS: -2.54
ROTB: 9

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70	57
kinase-selectivity-class	ACVR2B,AXL,BRAF,CDK9,GRK2,MAP2K6,MAPK7,TEK,TGFBR1	9
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	146.90	24.04	52	2245	46236	90579914
Platelet count decreased	56.67	24.04	38	2259	136931	90489219
Drug-induced liver injury	54.88	24.04	32	2265	90286	90535864
White blood cell count decreased	54.33	24.04	40	2257	167069	90459081
Neutrophil count decreased	45.18	24.04	26	2271	71506	90554644
Alanine aminotransferase increased	44.58	24.04	31	2266	118307	90507843
Aspartate aminotransferase increased	43.60	24.04	29	2268	102908	90523242
Lymphocyte count decreased	43.25	24.04	20	2277	35030	90591120
Eosinophilic pneumonia chronic	42.62	24.04	7	2290	224	90625926
Anaemia	38.59	24.04	46	2251	352756	90273394
Chronic disease	36.04	24.04	6	2291	209	90625941
Hypoalbuminaemia	32.60	24.04	13	2284	15884	90610266
Hypoproteinaemia	28.97	24.04	8	2289	3134	90623016

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	112.66	29.88	50	1637	51517	42568131
Platelet count decreased	71.09	29.88	52	1635	138529	42481119
Lymphocyte count decreased	60.70	29.88	27	1660	27782	42591866
Neutrophil count increased	59.06	29.88	24	1663	19780	42599868
Incision site pain	48.97	29.88	12	1675	1891	42617757
Drug-induced liver injury	46.77	29.88	25	1662	38248	42581400
Myelosuppression	42.72	29.88	24	1663	40437	42579211
Alanine aminotransferase increased	40.35	29.88	31	1656	88375	42531273
White blood cell count decreased	34.32	29.88	31	1656	110365	42509283
Neutrophil count decreased	30.59	29.88	23	1664	63392	42556256

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	240.89	25.05	98	3898	89197	110496106
Platelet count decreased	133.40	25.05	90	3906	230353	110354950
Lymphocyte count decreased	114.83	25.05	51	3945	57192	110528111
White blood cell count decreased	92.45	25.05	72	3924	229318	110355985
Drug-induced liver injury	91.91	25.05	56	3940	120011	110465292
Neutrophil count decreased	83.93	25.05	53	3943	120888	110464415
Alanine aminotransferase increased	81.29	25.05	61	3935	183712	110401591
Incision site pain	68.34	25.05	17	3979	3118	110582185
Myelosuppression	64.56	25.05	41	3955	94299	110491004
Aspartate aminotransferase increased	63.91	25.05	50	3946	159886	110425417
Neutrophil count increased	63.48	25.05	29	3967	34623	110550680
Hypoalbuminaemia	58.64	25.05	26	3970	28948	110556355
Anaemia	54.91	25.05	82	3914	547004	110038299
Red blood cells urine positive	42.32	25.05	13	3983	5172	110580131
Chronic disease	40.14	25.05	7	3989	224	110585079
Hypocalcaemia	38.80	25.05	26	3970	65340	110519963
Blood albumin decreased	38	25.05	19	3977	27633	110557670
Hypokalaemia	37.05	25.05	39	3957	182409	110402894
Hypoproteinaemia	36.51	25.05	12	3984	5933	110579370
Eosinophilic pneumonia chronic	33.86	25.05	7	3989	560	110584743
White blood cell count increased	29.71	25.05	26	3970	96816	110488487
Hyperuricaemia	29.26	25.05	13	3983	14518	110570785
Gamma-glutamyltransferase increased	28.49	25.05	21	3975	61288	110524015
Hypophosphataemia	26.68	25.05	16	3980	33166	110552137
Blood bilirubin increased	26.58	25.05	22	3974	75950	110509353
Liver injury	25.06	25.05	29	3967	150384	110434919

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V03AB32	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes
CHEBI has role	CHEBI:22586	antioxidant
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:75771	mouse metabolite
CHEBI has role	CHEBI:76971	<em>Escherichia coli</em> metabolite
CHEBI has role	CHEBI:77746	human metabolite
CHEBI has role	CHEBI:85046	skin lightening agent
CHEBI has role	CHEBI:176497	geroprotector

Related Drugs by ATC class:

V03AB Antidotes 28 drugs

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.97	acidic
pKa2	3.3	acidic
pKa3	9.09	acidic
pKa4	11.82	acidic
pKa5	13.85	acidic
pKa6	9.79	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glutathione S-transferase kappa 1	Enzyme	Q9Y2Q3	GSTK1_HUMAN		IC50	7.70		CHEMBL

External reference:

ID	Source
4020562	VUID
N0000148266	NUI
D00014	KEGG_DRUG
4020562	VANDF
C0202053	UMLSCUI
CHEBI:16856	CHEBI
0P0	PDB_CHEM_ID
CHEMBL1543	ChEMBL_ID
DB00143	DRUGBANK_ID
D005978	MESH_DESCRIPTOR_UI
124886	PUBCHEM_CID
6737	IUPHAR_LIGAND_ID
GAN16C9B8O	UNII
4890	RXNORM
37752	MMSL
382529	MMSL
NOCODE	MMSL
d09739	MMSL
003447	NDDF
423272009	SNOMEDCT_US
55477000	SNOMEDCT_US
GAN16C9B8O	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Bio-7 Serum	HUMAN OTC DRUG LABEL	2	71583-1002	LIQUID	3 g	TOPICAL	unapproved drug other	7 sections
Bio-7	HUMAN OTC DRUG LABEL	2	71583-1003	CREAM	3.26 g	TOPICAL	unapproved drug other	7 sections
GZE AHA BodyLotion	HUMAN OTC DRUG LABEL	3	74458-020	CREAM	0.10 g	TOPICAL	OTC Monograph Drug	10 sections
GZE Glutathione BrighteningSoap	HUMAN OTC DRUG LABEL	1	74458-331	SOAP	2 g	TOPICAL	OTC Monograph Drug	11 sections
MELAO Kojic Acid BodyLotion	HUMAN OTC DRUG LABEL	2	74458-357	LOTION	1 g	TOPICAL	OTC Monograph Drug	10 sections
HARUTO HANGOVER DEFENCEPATCH	HUMAN OTC DRUG LABEL	1	80094-0001	PATCH	1.42 mg	TOPICAL	unapproved drug other	7 sections
ST.LAWRENCE ANTI-AGING AND WHITENING MASK	HUMAN OTC DRUG LABEL	5	81309-010	LIQUID	4 g	TOPICAL	OTC Monograph Drug
Deyanling(Cranberry Flavored Collagen Peptide)	HUMAN OTC DRUG LABEL	3	82570-004	POWDER	5 g	TOPICAL	unapproved drug other	8 sections
Dark knucklee SERUM	HUMAN OTC DRUG LABEL	3	84423-004	OIL	0.25 mg	CUTANEOUS	OTC Monograph Drug	9 sections
5D Gluta Organic Exfoliating Cream Premium Glutathione Powder	HUMAN OTC DRUG LABEL	3	84423-005	EMULSION	0.00 g	CUTANEOUS	OTC Monograph Drug	9 sections
7 Days Whitening Face Cream	HUMAN OTC DRUG LABEL	3	84423-006	CREAM	0.25 mg	CUTANEOUS	OTC Monograph Drug	9 sections
STRONG WHITENING BATH	HUMAN OTC DRUG LABEL	2	84423-008	EMULSION	0.50 mg	CUTANEOUS	OTC Monograph Drug	7 sections
GLUTA PRIMME body oil	HUMAN OTC DRUG LABEL	2	84423-009	OIL	0.40 mg	CUTANEOUS	OTC Monograph Drug	8 sections
Glutathione And Kojic Atid Exfoliating BlackSoap	HUMAN OTC DRUG LABEL	3	84423-011	SOAP	0.25 mg	CUTANEOUS	OTC Monograph Drug	9 sections
5 DAYS WHITENING BOOSTER	HUMAN OTC DRUG LABEL	3	84423-017	LIQUID	0.80 mg	CUTANEOUS	OTC Monograph Drug	8 sections
Half Cast Whitening Serum STRONG	HUMAN OTC DRUG LABEL	3	84423-018	LIQUID	1.20 mg	CUTANEOUS	OTC Monograph Drug	8 sections
Diamond Radiance Body Serum	HUMAN OTC DRUG LABEL	2	84423-019	LIQUID	1.20 mg	CUTANEOUS	OTC Monograph Drug	8 sections
STRONG WHITENING BODY SERUM	HUMAN OTC DRUG LABEL	3	84423-020	LIQUID	0.36 mg	CUTANEOUS	OTC Monograph Drug	8 sections
7 DAYS ADUANCED WHITENING MAXIMUM BOOST SERUM	HUMAN OTC DRUG LABEL	3	84423-021	LIQUID	0.96 mg	CUTANEOUS	OTC Monograph Drug	8 sections
EXFOLIATING WHITENING BOYD SCRUB	HUMAN OTC DRUG LABEL	2	84423-023	EMULSION	0.90 mg	CUTANEOUS	OTC Monograph Drug	8 sections
Papaya Whitening BodyLotion	HUMAN OTC DRUG LABEL	2	84423-025	EMULSION	1.95 mg	CUTANEOUS	OTC Monograph Drug	8 sections
7 Days Extra Whitening BodyLotion	HUMAN OTC DRUG LABEL	2	84423-027	EMULSION	2.50 mg	CUTANEOUS	OTC Monograph Drug	8 sections
Shine BodyLotion	HUMAN OTC DRUG LABEL	2	84423-028	EMULSION	5 mg	CUTANEOUS	OTC Monograph Drug	8 sections
MIRACLE SUPER WHITE BODYLOTION	HUMAN OTC DRUG LABEL	5	84423-031	EMULSION	2.50 mg	CUTANEOUS	OTC Monograph Drug	8 sections
7Days Advanced Whitening BodyLotion	HUMAN OTC DRUG LABEL	3	84423-032	EMULSION	4 mg	CUTANEOUS	OTC Monograph Drug	8 sections
MAGIC POTION BLEACHING SHOWER GELIN	HUMAN OTC DRUG LABEL	2	84423-033	EMULSION	0.50 mg	CUTANEOUS	OTC Monograph Drug	8 sections
Goqi Berry Body Lotio	HUMAN OTC DRUG LABEL	2	84423-039	CREAM, AUGMENTED	2.50 mg	CUTANEOUS	OTC Monograph Drug	8 sections
Carrot BodyLotion	HUMAN OTC DRUG LABEL	3	84423-040	EMULSION	2.50 mg	CUTANEOUS	OTC Monograph Drug	8 sections
Papaya Oil Whitening BodyLotion	HUMAN OTC DRUG LABEL	3	84423-041	EMULSION	2.50 mg	CUTANEOUS	OTC Monograph Drug	8 sections
Brightening and Anti Aging BodyLotion	HUMAN OTC DRUG LABEL	3	84423-042	EMULSION	2.50 mg	CUTANEOUS	OTC Monograph Drug	8 sections

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glutathione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: