glutathione Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1312 70-18-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glutathione
  • GSH
  • glutathion
  • deltathione
  • glutinal
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
  • Molecular weight: 307.32
  • Formula: C10H17N3O6S
  • CLOGP: -3.05
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 5
  • TPSA: 158.82
  • ALOGS: -2.54
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 45.82 27.52 17 579 34404 46651062

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lymphocyte count decreased 66.38 30.42 24 882 19031 29932541
Neutrophil count increased 59.78 30.42 21 885 15302 29936270
Incision site pain 51.60 30.42 12 894 1992 29949580
Hepatic function abnormal 51.10 30.42 25 881 41920 29909652
Red blood cells urine positive 32.86 30.42 8 898 1609 29949963

Pharmacologic Action:

SourceCodeDescription
ATC V03AB32 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:77746 h. sapiens metabolites
CHEBI has role CHEBI:85046 melanogenesis inhibitors
CHEBI has role CHEBI:75772 baker's yeast metabolite

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.97 acidic
pKa2 3.3 acidic
pKa3 9.09 acidic
pKa4 11.82 acidic
pKa5 13.85 acidic
pKa6 9.79 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glutathione S-transferase kappa 1 Enzyme IC50 7.70 CHEMBL

External reference:

IDSource
4020562 VUID
N0000148266 NUI
D00014 KEGG_DRUG
4020562 VANDF
C0017817 UMLSCUI
CHEBI:16856 CHEBI
GSH PDB_CHEM_ID
CHEMBL1543 ChEMBL_ID
DB00143 DRUGBANK_ID
D005978 MESH_DESCRIPTOR_UI
124886 PUBCHEM_CID
6737 IUPHAR_LIGAND_ID
GAN16C9B8O UNII
4890 RXNORM
NOCODE MMSL
003447 NDDF
423272009 SNOMEDCT_US
55477000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Bio-7 Serum HUMAN OTC DRUG LABEL 2 71583-1002 LIQUID 3 g TOPICAL unapproved drug other 7 sections
Bio-7 HUMAN OTC DRUG LABEL 2 71583-1003 CREAM 3.26 g TOPICAL unapproved drug other 7 sections
Vista Advanced AREDS2 Formula HUMAN OTC DRUG LABEL 7 77790-009 CAPSULE 25 mg ORAL unapproved drug other 11 sections
HARUTO HANGOVER DEFENCEPATCH HUMAN OTC DRUG LABEL 1 80094-0001 PATCH 1.42 mg TOPICAL unapproved drug other 7 sections