glutathione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1312 70-18-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glutathione
  • GSH
  • glutathion
  • deltathione
  • glutinal
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
  • Molecular weight: 307.32
  • Formula: C10H17N3O6S
  • CLOGP: -3.05
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 5
  • TPSA: 158.82
  • ALOGS: -2.54
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 69.68 24.70 27 1247 34531 56256262
Drug-induced liver injury 36.27 24.70 17 1257 34445 56256348
Eosinophilic pneumonia chronic 30.33 24.70 5 1269 184 56290609
Bowel movement irregularity 27.00 24.70 8 1266 4515 56286278
Defaecation urgency 24.75 24.70 7 1267 3352 56287441

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 80.14 30.21 36 1127 41186 31654995
Lymphocyte count decreased 59.93 30.21 24 1139 20625 31675556
Neutrophil count increased 55.23 30.21 21 1142 15710 31680471
Incision site pain 50.33 30.21 12 1151 1822 31694359
Platelet count decreased 44.93 30.21 35 1128 110400 31585781

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 134.88 25.71 58 2228 67938 70858220
Incision site pain 72.44 25.71 17 2269 2744 70923414
Neutrophil count increased 63.53 25.71 26 2260 26769 70899389
Lymphocyte count decreased 60.40 25.71 29 2257 43510 70882648
Platelet count decreased 55.80 25.71 46 2240 178176 70747982
Drug-induced liver injury 53.44 25.71 29 2257 56084 70870074
Alanine aminotransferase increased 33.94 25.71 32 2254 147448 70778710
Liver injury 33.02 25.71 19 2267 41016 70885142
White blood cell count increased 30.57 25.71 22 2264 69551 70856607
Red blood cells urine positive 27.91 25.71 9 2277 4700 70921458
Bone marrow failure 27.44 25.71 18 2268 48992 70877166

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AB32 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:85046 skin lightening agents
CHEBI has role CHEBI:176497 geroprotectors
CHEBI has role CHEBI:75772 S. cerevisiae metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.97 acidic
pKa2 3.3 acidic
pKa3 9.09 acidic
pKa4 11.82 acidic
pKa5 13.85 acidic
pKa6 9.79 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glutathione S-transferase kappa 1 Enzyme IC50 7.70 CHEMBL

External reference:

IDSource
4020562 VUID
N0000148266 NUI
D00014 KEGG_DRUG
4020562 VANDF
C0017817 UMLSCUI
CHEBI:16856 CHEBI
0P0 PDB_CHEM_ID
CHEMBL1543 ChEMBL_ID
DB00143 DRUGBANK_ID
D005978 MESH_DESCRIPTOR_UI
124886 PUBCHEM_CID
6737 IUPHAR_LIGAND_ID
GAN16C9B8O UNII
4890 RXNORM
NOCODE MMSL
003447 NDDF
423272009 SNOMEDCT_US
55477000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Bio-7 Serum HUMAN OTC DRUG LABEL 2 71583-1002 LIQUID 3 g TOPICAL unapproved drug other 7 sections
Bio-7 HUMAN OTC DRUG LABEL 2 71583-1003 CREAM 3.26 g TOPICAL unapproved drug other 7 sections
HARUTO HANGOVER DEFENCEPATCH HUMAN OTC DRUG LABEL 1 80094-0001 PATCH 1.42 mg TOPICAL unapproved drug other 7 sections
Deyanling(Cranberry Flavored Collagen Peptide) HUMAN OTC DRUG LABEL 3 82570-004 POWDER 5 g TOPICAL unapproved drug other 8 sections