glutathione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1312 70-18-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glutathione
  • GSH
  • glutathion
  • deltathione
  • glutinal
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
  • Molecular weight: 307.32
  • Formula: C10H17N3O6S
  • CLOGP: -3.05
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 5
  • TPSA: 158.82
  • ALOGS: -2.54
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 56.69 25.76 23 1139 32658 50571304
Drug-induced liver injury 36.12 25.76 16 1146 28079 50575883
Eosinophilic pneumonia chronic 30.65 25.76 5 1157 170 50603792
Bowel movement irregularity 27.92 25.76 8 1154 3960 50600002

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 66.86 31.18 31 1023 39228 29534245
Lymphocyte count decreased 58.68 31.18 23 1031 19248 29554225
Neutrophil count increased 53.49 31.18 20 1034 14722 29558751
Incision site pain 51.02 31.18 12 1042 1771 29571702
Platelet count decreased 38.73 31.18 31 1023 104641 29468832

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatic function abnormal 111.81 23.83 50 2028 64263 64432391
Incision site pain 73.13 23.83 17 2061 2637 64494017
Neutrophil count increased 61.66 23.83 25 2053 25149 64471505
Lymphocyte count decreased 59.20 23.83 28 2050 40671 64455983
Drug-induced liver injury 46.43 23.83 25 2053 47618 64449036
Platelet count decreased 45.77 23.83 40 2038 167671 64328983
White blood cell count increased 31.62 23.83 22 2056 65992 64430662
Alanine aminotransferase increased 29.79 23.83 29 2049 139002 64357652
Red blood cells urine positive 28.36 23.83 9 2069 4469 64492185
Bone marrow failure 27.81 23.83 18 2060 47934 64448720
Haemoglobin decreased 26.53 23.83 32 2046 195031 64301623
Blood albumin decreased 26.09 23.83 13 2065 21060 64475594
Eosinophilic pneumonia chronic 25.28 23.83 5 2073 360 64496294
Liver injury 24.46 23.83 14 2064 29918 64466736
Blood urea increased 24.20 23.83 16 2062 44137 64452517

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AB32 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:85046 skin lightening agents
CHEBI has role CHEBI:176497 geroprotectors
CHEBI has role CHEBI:75772 S. cerevisiae metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.97 acidic
pKa2 3.3 acidic
pKa3 9.09 acidic
pKa4 11.82 acidic
pKa5 13.85 acidic
pKa6 9.79 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glutathione S-transferase kappa 1 Enzyme IC50 7.70 CHEMBL

External reference:

IDSource
4020562 VUID
N0000148266 NUI
D00014 KEGG_DRUG
4020562 VANDF
C0017817 UMLSCUI
CHEBI:16856 CHEBI
0P0 PDB_CHEM_ID
CHEMBL1543 ChEMBL_ID
DB00143 DRUGBANK_ID
D005978 MESH_DESCRIPTOR_UI
124886 PUBCHEM_CID
6737 IUPHAR_LIGAND_ID
GAN16C9B8O UNII
4890 RXNORM
NOCODE MMSL
003447 NDDF
423272009 SNOMEDCT_US
55477000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Bio-7 Serum HUMAN OTC DRUG LABEL 2 71583-1002 LIQUID 3 g TOPICAL unapproved drug other 7 sections
Bio-7 HUMAN OTC DRUG LABEL 2 71583-1003 CREAM 3.26 g TOPICAL unapproved drug other 7 sections
HARUTO HANGOVER DEFENCEPATCH HUMAN OTC DRUG LABEL 1 80094-0001 PATCH 1.42 mg TOPICAL unapproved drug other 7 sections
Deyanling(Cranberry Flavored Collagen Peptide) HUMAN OTC DRUG LABEL 3 82570-004 POWDER 5 g TOPICAL unapproved drug other 8 sections