mometasone furoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prednisone and prednisolone derivatives | 1832 | 83919-23-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for skin disorders.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.20 | mg | N |
| 0.40 | mg | Inhal.powder |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.02 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 2.20 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 12.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.40 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 30, 1987 | FDA | MERCK SHARP DOHME | |
| June 29, 2020 | PMDA | Novartis Pharma K.K. |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product quality issue | 4458.57 | 11.95 | 1527 | 49934 | 29331 | 50524332 |
| No adverse event | 2849.04 | 11.95 | 1124 | 50337 | 32454 | 50521209 |
| Poor quality device used | 2520.60 | 11.95 | 540 | 50921 | 1311 | 50552352 |
| Product dose omission issue | 1727.10 | 11.95 | 1452 | 50009 | 182386 | 50371277 |
| Product container issue | 640.93 | 11.95 | 170 | 51291 | 1262 | 50552401 |
| Device malfunction | 551.51 | 11.95 | 281 | 51180 | 14840 | 50538823 |
| Asthma | 527.89 | 11.95 | 547 | 50914 | 88790 | 50464873 |
| Circumstance or information capable of leading to medication error | 401.93 | 11.95 | 143 | 51318 | 3045 | 50550618 |
| Gastrooesophageal reflux disease | 369.16 | 11.95 | 421 | 51040 | 76007 | 50477656 |
| Wheezing | 353.82 | 11.95 | 373 | 51088 | 61674 | 50491989 |
| Sputum discoloured | 221.25 | 11.95 | 149 | 51312 | 13246 | 50540417 |
| Cough | 219.54 | 11.95 | 639 | 50822 | 240625 | 50313038 |
| Ejection fraction | 198.64 | 11.95 | 66 | 51395 | 1134 | 50552529 |
| Productive cough | 192.10 | 11.95 | 252 | 51209 | 52442 | 50501221 |
| Pneumonia aspiration | 175.88 | 11.95 | 186 | 51275 | 30818 | 50522845 |
| Rhinitis allergic | 168.84 | 11.95 | 100 | 51361 | 7100 | 50546563 |
| Incorrect dose administered | 154.39 | 11.95 | 217 | 51244 | 48197 | 50505466 |
| Infective pulmonary exacerbation of cystic fibrosis | 152.64 | 11.95 | 97 | 51364 | 7812 | 50545851 |
| Sleep disorder due to a general medical condition | 151.29 | 11.95 | 94 | 51367 | 7277 | 50546386 |
| Toxicity to various agents | 151.28 | 11.95 | 19 | 51442 | 212480 | 50341183 |
| Sensitisation | 147.99 | 11.95 | 57 | 51404 | 1525 | 50552138 |
| Dyspnoea | 146.61 | 11.95 | 1004 | 50457 | 546604 | 50007059 |
| Presbyacusis | 141.74 | 11.95 | 65 | 51396 | 2711 | 50550952 |
| Sleep apnoea syndrome | 140.38 | 11.95 | 146 | 51315 | 23722 | 50529941 |
| Steroid withdrawal syndrome | 137.38 | 11.95 | 41 | 51420 | 486 | 50553177 |
| Polycystic ovaries | 135.80 | 11.95 | 61 | 51400 | 2423 | 50551240 |
| Pleural fibrosis | 135.39 | 11.95 | 67 | 51394 | 3317 | 50550346 |
| Pleural thickening | 130.02 | 11.95 | 60 | 51401 | 2539 | 50551124 |
| Blood magnesium increased | 118.14 | 11.95 | 58 | 51403 | 2822 | 50550841 |
| Deafness neurosensory | 114.74 | 11.95 | 66 | 51395 | 4435 | 50549228 |
| Synovitis | 108.31 | 11.95 | 4 | 51457 | 123861 | 50429802 |
| Nasal polyps | 106.46 | 11.95 | 52 | 51409 | 2502 | 50551161 |
| Obstructive airways disorder | 105.33 | 11.95 | 103 | 51358 | 15549 | 50538114 |
| Blood test abnormal | 104.61 | 11.95 | 89 | 51372 | 11230 | 50542433 |
| Glossodynia | 100.13 | 11.95 | 4 | 51457 | 115565 | 50438098 |
| Systemic lupus erythematosus | 96.63 | 11.95 | 14 | 51447 | 140608 | 50413055 |
| Epigastric discomfort | 96.21 | 11.95 | 65 | 51396 | 5805 | 50547858 |
| Chest discomfort | 95.24 | 11.95 | 257 | 51204 | 92465 | 50461198 |
| Nasal congestion | 93.23 | 11.95 | 178 | 51283 | 50942 | 50502721 |
| Hand deformity | 88.41 | 11.95 | 3 | 51458 | 100196 | 50453467 |
| Full blood count abnormal | 85.40 | 11.95 | 112 | 51349 | 23276 | 50530387 |
| Underdose | 84.97 | 11.95 | 104 | 51357 | 20174 | 50533489 |
| Death | 84.62 | 11.95 | 125 | 51336 | 325254 | 50228409 |
| Coma | 83.47 | 11.95 | 181 | 51280 | 56698 | 50496965 |
| Acute kidney injury | 81.99 | 11.95 | 67 | 51394 | 227991 | 50325672 |
| Cyst | 81.63 | 11.95 | 80 | 51381 | 12107 | 50541556 |
| Contraindicated product administered | 79.81 | 11.95 | 26 | 51435 | 148932 | 50404731 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 70.23 | 11.95 | 24 | 51437 | 451 | 50553212 |
| Bone cyst | 69.09 | 11.95 | 36 | 51425 | 1988 | 50551675 |
| Product taste abnormal | 68.18 | 11.95 | 34 | 51427 | 1711 | 50551952 |
| Sinusitis | 68.07 | 11.95 | 348 | 51113 | 170210 | 50383453 |
| Asthma exercise induced | 65.61 | 11.95 | 20 | 51441 | 256 | 50553407 |
| Osteopenia | 64.48 | 11.95 | 83 | 51378 | 16935 | 50536728 |
| Therapeutic product effect incomplete | 62.50 | 11.95 | 220 | 51241 | 91295 | 50462368 |
| Wrong technique in device usage process | 62.16 | 11.95 | 36 | 51425 | 2450 | 50551213 |
| Neutropenia | 61.69 | 11.95 | 37 | 51424 | 147928 | 50405735 |
| Maternal exposure during pregnancy | 61.14 | 11.95 | 44 | 51417 | 159734 | 50393929 |
| Thrombocytopenia | 60.53 | 11.95 | 27 | 51434 | 127646 | 50426017 |
| Factor V Leiden mutation | 59.31 | 11.95 | 17 | 51444 | 173 | 50553490 |
| Pericarditis | 58.53 | 11.95 | 6 | 51455 | 78683 | 50474980 |
| Wound | 57.48 | 11.95 | 18 | 51443 | 105776 | 50447887 |
| Anaemia | 57.18 | 11.95 | 106 | 51355 | 252350 | 50301313 |
| Nephrectomy | 57.05 | 11.95 | 24 | 51437 | 811 | 50552852 |
| Rhinitis | 56.54 | 11.95 | 55 | 51406 | 8246 | 50545417 |
| Dry eye | 56.35 | 11.95 | 110 | 51351 | 31985 | 50521678 |
| Poor quality product administered | 55.45 | 11.95 | 35 | 51426 | 2784 | 50550879 |
| Vomiting | 54.67 | 11.95 | 262 | 51199 | 460496 | 50093167 |
| Sleep disorder | 53.09 | 11.95 | 153 | 51308 | 57130 | 50496533 |
| Overdose | 52.36 | 11.95 | 18 | 51443 | 99709 | 50453954 |
| Off label use | 51.61 | 11.95 | 278 | 51183 | 474148 | 50079515 |
| Intentional overdose | 51.44 | 11.95 | 3 | 51458 | 62501 | 50491162 |
| Osteosclerosis | 51.18 | 11.95 | 36 | 51425 | 3431 | 50550232 |
| Somnolence | 50.26 | 11.95 | 299 | 51162 | 154686 | 50398977 |
| Total lung capacity increased | 50.02 | 11.95 | 21 | 51440 | 706 | 50552957 |
| Drug interaction | 48.65 | 11.95 | 80 | 51381 | 199541 | 50354122 |
| Bronchiectasis | 48.45 | 11.95 | 56 | 51405 | 10227 | 50543436 |
| Drug abuse | 46.00 | 11.95 | 4 | 51457 | 59842 | 50493821 |
| Swelling | 45.77 | 11.95 | 84 | 51377 | 200788 | 50352875 |
| Lung opacity | 45.20 | 11.95 | 27 | 51434 | 1946 | 50551717 |
| Abdominal discomfort | 45.08 | 11.95 | 106 | 51355 | 231535 | 50322128 |
| Confusional state | 44.85 | 11.95 | 75 | 51386 | 185853 | 50367810 |
| Cardiac arrest | 44.08 | 11.95 | 15 | 51446 | 83636 | 50470027 |
| Pancytopenia | 42.69 | 11.95 | 16 | 51445 | 84014 | 50469649 |
| Alopecia | 42.40 | 11.95 | 119 | 51342 | 244928 | 50308735 |
| Middle insomnia | 41.75 | 11.95 | 51 | 51410 | 9870 | 50543793 |
| Forced expiratory volume decreased | 41.52 | 11.95 | 35 | 51426 | 4359 | 50549304 |
| Leukopenia | 41.42 | 11.95 | 9 | 51452 | 67519 | 50486144 |
| Upper-airway cough syndrome | 41.02 | 11.95 | 47 | 51414 | 8503 | 50545160 |
| Prolonged expiration | 40.35 | 11.95 | 18 | 51443 | 703 | 50552960 |
| Joint swelling | 40.34 | 11.95 | 122 | 51339 | 245164 | 50308499 |
| Hypotension | 40.26 | 11.95 | 115 | 51346 | 235354 | 50318309 |
| Blood potassium increased | 40.13 | 11.95 | 65 | 51396 | 16333 | 50537330 |
| Oropharyngeal pain | 40.00 | 11.95 | 171 | 51290 | 77630 | 50476033 |
| Asthenopia | 39.80 | 11.95 | 25 | 51436 | 1972 | 50551691 |
| Heart sounds | 39.38 | 11.95 | 17 | 51444 | 613 | 50553050 |
| Discomfort | 38.70 | 11.95 | 32 | 51429 | 108348 | 50445315 |
| Carpal tunnel syndrome | 38.70 | 11.95 | 65 | 51396 | 16828 | 50536835 |
| Skin weeping | 38.67 | 11.95 | 15 | 51446 | 409 | 50553254 |
| Occupational asthma | 38.02 | 11.95 | 11 | 51450 | 116 | 50553547 |
| Eosinophilic granulomatosis with polyangiitis | 37.77 | 11.95 | 24 | 51437 | 1931 | 50551732 |
| Bronchopulmonary aspergillosis allergic | 37.30 | 11.95 | 20 | 51441 | 1171 | 50552492 |
| Sinus disorder | 37.05 | 11.95 | 67 | 51394 | 18391 | 50535272 |
| Rhinorrhoea | 36.92 | 11.95 | 126 | 51335 | 51457 | 50502206 |
| Helicobacter infection | 36.42 | 11.95 | 4 | 51457 | 49698 | 50503965 |
| Dehydration | 36.29 | 11.95 | 62 | 51399 | 152387 | 50401276 |
| Incorrect dose administered by product | 35.93 | 11.95 | 11 | 51450 | 143 | 50553520 |
| Cardio-respiratory arrest | 35.56 | 11.95 | 6 | 51455 | 53886 | 50499777 |
| General physical health deterioration | 34.76 | 11.95 | 57 | 51404 | 142377 | 50411286 |
| Skin lesion | 34.66 | 11.95 | 81 | 51380 | 26646 | 50527017 |
| Multiple organ dysfunction syndrome | 34.58 | 11.95 | 5 | 51456 | 50332 | 50503331 |
| Condition aggravated | 33.38 | 11.95 | 172 | 51289 | 296886 | 50256777 |
| Bronchial obstruction | 33.10 | 11.95 | 19 | 51442 | 1271 | 50552392 |
| Hyperkalaemia | 32.52 | 11.95 | 5 | 51456 | 48084 | 50505579 |
| Hyponatraemia | 32.37 | 11.95 | 30 | 51431 | 96109 | 50457554 |
| Infusion related reaction | 31.85 | 11.95 | 79 | 51382 | 169478 | 50384185 |
| Respiration abnormal | 31.41 | 11.95 | 32 | 51429 | 5070 | 50548593 |
| Fall | 31.19 | 11.95 | 206 | 51255 | 334726 | 50218937 |
| Oesophageal dilatation | 31.15 | 11.95 | 12 | 51449 | 321 | 50553342 |
| Exposure during pregnancy | 30.88 | 11.95 | 47 | 51414 | 120968 | 50432695 |
| Pre-existing condition improved | 30.70 | 11.95 | 37 | 51424 | 7060 | 50546603 |
| Acquired haemophilia | 30.65 | 11.95 | 16 | 51445 | 887 | 50552776 |
| Deformity | 30.50 | 11.95 | 39 | 51422 | 7901 | 50545762 |
| Respiratory tract congestion | 30.37 | 11.95 | 53 | 51408 | 14146 | 50539517 |
| Impaired healing | 29.70 | 11.95 | 17 | 51444 | 69769 | 50483894 |
| Circumstance or information capable of leading to device use error | 29.68 | 11.95 | 9 | 51452 | 113 | 50553550 |
| Nasal mucosal disorder | 29.37 | 11.95 | 12 | 51449 | 376 | 50553287 |
| Burning sensation | 29.08 | 11.95 | 107 | 51354 | 45339 | 50508324 |
| Ejection fraction abnormal | 28.72 | 11.95 | 15 | 51446 | 832 | 50552831 |
| Enthesopathy | 28.69 | 11.95 | 36 | 51425 | 7157 | 50546506 |
| Headache | 28.61 | 11.95 | 695 | 50766 | 505840 | 50047823 |
| Nasopharyngitis | 28.60 | 11.95 | 311 | 51150 | 192616 | 50361047 |
| Adrenal suppression | 28.31 | 11.95 | 15 | 51446 | 857 | 50552806 |
| Exostosis | 28.25 | 11.95 | 46 | 51415 | 11607 | 50542056 |
| Product odour abnormal | 28.00 | 11.95 | 16 | 51445 | 1061 | 50552602 |
| Dysphonia | 27.83 | 11.95 | 95 | 51366 | 38797 | 50514866 |
| Rales | 27.82 | 11.95 | 42 | 51419 | 9936 | 50543727 |
| Bronchitis | 27.60 | 11.95 | 191 | 51270 | 103968 | 50449695 |
| Haemoglobin decreased | 27.38 | 11.95 | 55 | 51406 | 127161 | 50426502 |
| Product availability issue | 26.98 | 11.95 | 20 | 51441 | 2068 | 50551595 |
| Platelet count decreased | 26.79 | 11.95 | 38 | 51423 | 100688 | 50452975 |
| Expired product administered | 26.52 | 11.95 | 30 | 51431 | 5352 | 50548311 |
| Neutrophil count decreased | 26.52 | 11.95 | 7 | 51454 | 46019 | 50507644 |
| Pain | 26.15 | 11.95 | 423 | 51038 | 578480 | 49975183 |
| Pulmonary function test decreased | 26.03 | 11.95 | 24 | 51437 | 3364 | 50550299 |
| Tenosynovitis | 26.01 | 11.95 | 42 | 51419 | 10523 | 50543140 |
| Febrile neutropenia | 25.82 | 11.95 | 37 | 51424 | 97630 | 50456033 |
| Hepatic enzyme increased | 25.80 | 11.95 | 64 | 51397 | 137316 | 50416347 |
| Decreased appetite | 25.68 | 11.95 | 111 | 51350 | 200812 | 50352851 |
| Eczema | 25.39 | 11.95 | 65 | 51396 | 22637 | 50531026 |
| Total lung capacity decreased | 25.32 | 11.95 | 16 | 51445 | 1275 | 50552388 |
| Arthropathy | 24.90 | 11.95 | 80 | 51381 | 157826 | 50395837 |
| Upper respiratory tract infection | 24.54 | 11.95 | 132 | 51329 | 65766 | 50487897 |
| Croup infectious | 24.32 | 11.95 | 11 | 51450 | 444 | 50553219 |
| Vital capacity decreased | 24.32 | 11.95 | 14 | 51447 | 942 | 50552721 |
| Cardiac disorder | 24.07 | 11.95 | 97 | 51364 | 42882 | 50510781 |
| Lactic acidosis | 23.65 | 11.95 | 3 | 51458 | 33352 | 50520311 |
| Sarcoidosis | 23.10 | 11.95 | 27 | 51434 | 4990 | 50548673 |
| CFTR gene mutation | 23.08 | 11.95 | 7 | 51454 | 88 | 50553575 |
| Diaphragmatic rupture | 23.05 | 11.95 | 9 | 51452 | 250 | 50553413 |
| Bradycardia | 23.02 | 11.95 | 19 | 51442 | 64407 | 50489256 |
| Cardiac failure | 23.01 | 11.95 | 26 | 51435 | 76014 | 50477649 |
| Female sterilisation | 23.00 | 11.95 | 11 | 51450 | 505 | 50553158 |
| Septic shock | 22.84 | 11.95 | 15 | 51446 | 57160 | 50496503 |
| Diarrhoea | 22.74 | 11.95 | 442 | 51019 | 588034 | 49965629 |
| Sepsis | 22.63 | 11.95 | 65 | 51396 | 132860 | 50420803 |
| Dyspnoea exertional | 22.13 | 11.95 | 107 | 51354 | 51126 | 50502537 |
| Seizure | 22.06 | 11.95 | 55 | 51406 | 117819 | 50435844 |
| Osteoarthritis | 21.97 | 11.95 | 132 | 51329 | 68474 | 50485189 |
| Loss of personal independence in daily activities | 21.94 | 11.95 | 134 | 51327 | 69916 | 50483747 |
| Disease progression | 21.89 | 11.95 | 40 | 51421 | 95826 | 50457837 |
| Inappropriate schedule of product administration | 21.62 | 11.95 | 136 | 51325 | 71695 | 50481968 |
| Mucosal inflammation | 21.49 | 11.95 | 7 | 51454 | 40135 | 50513528 |
| Palpitations | 21.43 | 11.95 | 167 | 51294 | 94339 | 50459324 |
| Anosmia | 21.25 | 11.95 | 23 | 51438 | 3908 | 50549755 |
| Product dosage form issue | 21.24 | 11.95 | 5 | 51456 | 21 | 50553642 |
| Folliculitis | 20.72 | 11.95 | 7 | 51454 | 39218 | 50514445 |
| Lung perforation | 20.68 | 11.95 | 6 | 51455 | 64 | 50553599 |
| Respiratory arrest | 20.57 | 11.95 | 3 | 51458 | 30006 | 50523657 |
| Renal failure | 20.55 | 11.95 | 49 | 51412 | 106584 | 50447079 |
| Electrocardiogram QT prolonged | 20.20 | 11.95 | 14 | 51447 | 51872 | 50501791 |
| Gastrointestinal haemorrhage | 20.16 | 11.95 | 27 | 51434 | 73294 | 50480369 |
| Suicide attempt | 20.09 | 11.95 | 14 | 51447 | 51718 | 50501945 |
| Therapeutic product effect decreased | 20.03 | 11.95 | 71 | 51390 | 135979 | 50417684 |
| Throat irritation | 20.02 | 11.95 | 72 | 51389 | 30167 | 50523496 |
| Product leakage | 19.71 | 11.95 | 10 | 51451 | 522 | 50553141 |
| Therapy non-responder | 19.56 | 11.95 | 14 | 51447 | 51008 | 50502655 |
| Hippocampal sclerosis | 19.53 | 11.95 | 6 | 51455 | 79 | 50553584 |
| Nasal dryness | 19.45 | 11.95 | 21 | 51440 | 3558 | 50550105 |
| Respiratory tract infection | 19.33 | 11.95 | 74 | 51387 | 31943 | 50521720 |
| Skin burning sensation | 19.21 | 11.95 | 36 | 51425 | 10149 | 50543514 |
| Adiposis dolorosa | 19.00 | 11.95 | 8 | 51453 | 271 | 50553392 |
| Depressed level of consciousness | 18.96 | 11.95 | 15 | 51446 | 51938 | 50501725 |
| Sinus congestion | 18.84 | 11.95 | 43 | 51418 | 13928 | 50539735 |
| Interstitial lung disease | 18.61 | 11.95 | 16 | 51445 | 53160 | 50500503 |
| Painful respiration | 18.59 | 11.95 | 17 | 51444 | 2358 | 50551305 |
| Irritable bowel syndrome | 18.59 | 11.95 | 15 | 51446 | 51426 | 50502237 |
| Seasonal allergy | 18.51 | 11.95 | 44 | 51417 | 14632 | 50539031 |
| Ureteral disorder | 18.46 | 11.95 | 8 | 51453 | 291 | 50553372 |
| Hepatic failure | 18.43 | 11.95 | 5 | 51456 | 32278 | 50521385 |
| Genital rash | 18.18 | 11.95 | 9 | 51452 | 446 | 50553217 |
| Exposure via skin contact | 18.04 | 11.95 | 7 | 51454 | 191 | 50553472 |
| Epistaxis | 17.96 | 11.95 | 119 | 51342 | 63835 | 50489828 |
| Red blood cell sedimentation rate increased | 17.87 | 11.95 | 4 | 51457 | 29412 | 50524251 |
| Procedural anxiety | 17.69 | 11.95 | 10 | 51451 | 650 | 50553013 |
| Focal segmental glomerulosclerosis | 17.68 | 11.95 | 13 | 51448 | 1328 | 50552335 |
| International normalised ratio increased | 17.67 | 11.95 | 11 | 51450 | 43141 | 50510522 |
| Dystrophic calcification | 17.59 | 11.95 | 6 | 51455 | 112 | 50553551 |
| Hypothyroidism | 17.52 | 11.95 | 75 | 51386 | 34050 | 50519613 |
| Erythema marginatum | 17.15 | 11.95 | 4 | 51457 | 16 | 50553647 |
| Haemoptysis | 17.02 | 11.95 | 61 | 51400 | 25512 | 50528151 |
| Purpura senile | 16.89 | 11.95 | 9 | 51452 | 520 | 50553143 |
| Temporal lobe epilepsy | 16.83 | 11.95 | 8 | 51453 | 362 | 50553301 |
| Tarsal tunnel syndrome | 16.74 | 11.95 | 9 | 51452 | 530 | 50553133 |
| Fibromyalgia | 16.68 | 11.95 | 90 | 51371 | 44888 | 50508775 |
| Secretion discharge | 16.51 | 11.95 | 33 | 51428 | 9758 | 50543905 |
| Blood immunoglobulin E decreased | 16.33 | 11.95 | 5 | 51456 | 65 | 50553598 |
| Knee arthroplasty | 16.33 | 11.95 | 8 | 51453 | 35838 | 50517825 |
| Obstruction | 16.31 | 11.95 | 15 | 51446 | 2096 | 50551567 |
| Anxiety | 16.14 | 11.95 | 262 | 51199 | 177344 | 50376319 |
| Allergic sinusitis | 16.13 | 11.95 | 9 | 51452 | 570 | 50553093 |
| Product quality control issue | 16.10 | 11.95 | 4 | 51457 | 22 | 50553641 |
| Hypothalamic pituitary adrenal axis suppression | 16.07 | 11.95 | 6 | 51455 | 147 | 50553516 |
| White blood cell count decreased | 15.82 | 11.95 | 63 | 51398 | 116659 | 50437004 |
| Product administration error | 15.78 | 11.95 | 50 | 51411 | 19649 | 50534014 |
| Type 2 diabetes mellitus | 15.73 | 11.95 | 73 | 51388 | 34302 | 50519361 |
| Nasal oedema | 15.57 | 11.95 | 10 | 51451 | 820 | 50552843 |
| Hyperaesthesia | 15.56 | 11.95 | 29 | 51432 | 8144 | 50545519 |
| Tongue pruritus | 15.38 | 11.95 | 8 | 51453 | 440 | 50553223 |
| Cardiac failure congestive | 15.30 | 11.95 | 40 | 51421 | 84342 | 50469321 |
| Product administered to patient of inappropriate age | 15.30 | 11.95 | 16 | 51445 | 2614 | 50551049 |
| Urticaria | 15.28 | 11.95 | 200 | 51261 | 129361 | 50424302 |
| Eosinophil count abnormal | 15.20 | 11.95 | 8 | 51453 | 451 | 50553212 |
| Drug reaction with eosinophilia and systemic symptoms | 15.14 | 11.95 | 5 | 51456 | 28419 | 50525244 |
| Hip arthroplasty | 15.11 | 11.95 | 6 | 51455 | 30423 | 50523240 |
| Blister | 15.10 | 11.95 | 41 | 51420 | 85377 | 50468286 |
| Post-traumatic stress disorder | 14.77 | 11.95 | 20 | 51441 | 4283 | 50549380 |
| Periodic limb movement disorder | 14.72 | 11.95 | 6 | 51455 | 187 | 50553476 |
| Encephalopathy | 14.65 | 11.95 | 8 | 51453 | 33703 | 50519960 |
| Glaucoma | 14.62 | 11.95 | 42 | 51419 | 15644 | 50538019 |
| Pregnancy | 14.41 | 11.95 | 6 | 51455 | 29571 | 50524092 |
| Rash | 14.40 | 11.95 | 337 | 51124 | 437134 | 50116529 |
| Dermatitis atopic | 14.39 | 11.95 | 18 | 51443 | 3568 | 50550095 |
| Depressive symptom | 14.36 | 11.95 | 17 | 51444 | 3183 | 50550480 |
| Urinary tract infection | 14.36 | 11.95 | 152 | 51309 | 223868 | 50329795 |
| Intentional self-injury | 14.33 | 11.95 | 3 | 51458 | 23109 | 50530554 |
| Hypokalaemia | 14.27 | 11.95 | 44 | 51417 | 87948 | 50465715 |
| Haematocrit decreased | 14.21 | 11.95 | 9 | 51452 | 34967 | 50518696 |
| Pulmonary eosinophilia | 14.15 | 11.95 | 6 | 51455 | 207 | 50553456 |
| Exposure to fungus | 14.07 | 11.95 | 5 | 51456 | 106 | 50553557 |
| Bursitis | 14.06 | 11.95 | 52 | 51409 | 22083 | 50531580 |
| Mesenteric haemorrhage | 13.84 | 11.95 | 4 | 51457 | 42 | 50553621 |
| Hypocalcaemia | 13.79 | 11.95 | 5 | 51456 | 26811 | 50526852 |
| Pulmonary mass | 13.65 | 11.95 | 46 | 51415 | 18659 | 50535004 |
| Diaphragmatic paralysis | 13.64 | 11.95 | 8 | 51453 | 557 | 50553106 |
| Ascites | 13.54 | 11.95 | 10 | 51451 | 35851 | 50517812 |
| Fractional exhaled nitric oxide increased | 13.53 | 11.95 | 3 | 51458 | 9 | 50553654 |
| Skin atrophy | 13.48 | 11.95 | 19 | 51442 | 4226 | 50549437 |
| Sneezing | 13.48 | 11.95 | 38 | 51423 | 14006 | 50539657 |
| Peritoneal perforation | 13.45 | 11.95 | 5 | 51456 | 121 | 50553542 |
| Bronchitis chronic | 13.28 | 11.95 | 18 | 51443 | 3859 | 50549804 |
| Menopause | 13.26 | 11.95 | 14 | 51447 | 2313 | 50551350 |
| C-reactive protein increased | 13.24 | 11.95 | 30 | 51431 | 66444 | 50487219 |
| Paranasal sinus inflammation | 13.05 | 11.95 | 7 | 51454 | 410 | 50553253 |
| Cerebral infarction | 13 | 11.95 | 3 | 51458 | 21601 | 50532062 |
| Lower respiratory tract congestion | 12.96 | 11.95 | 13 | 51448 | 2023 | 50551640 |
| Lichenification | 12.94 | 11.95 | 7 | 51454 | 417 | 50553246 |
| Exercise tolerance decreased | 12.86 | 11.95 | 20 | 51441 | 4854 | 50548809 |
| Incorrect route of product administration | 12.83 | 11.95 | 45 | 51416 | 18621 | 50535042 |
| Breath sounds abnormal | 12.82 | 11.95 | 26 | 51435 | 7766 | 50545897 |
| Intentional product use issue | 12.80 | 11.95 | 38 | 51423 | 76880 | 50476783 |
| Flail chest | 12.66 | 11.95 | 4 | 51457 | 58 | 50553605 |
| Skin wrinkling | 12.64 | 11.95 | 9 | 51452 | 874 | 50552789 |
| Hypoglycaemia | 12.55 | 11.95 | 22 | 51439 | 53559 | 50500104 |
| Cystic fibrosis | 12.50 | 11.95 | 15 | 51446 | 2849 | 50550814 |
| Asthenia | 12.46 | 11.95 | 239 | 51222 | 318803 | 50234860 |
| Unresponsive to stimuli | 12.26 | 11.95 | 8 | 51453 | 30601 | 50523062 |
| Metastases to lymph nodes | 12.23 | 11.95 | 24 | 51437 | 7000 | 50546663 |
| Hospitalisation | 12.20 | 11.95 | 114 | 51347 | 67823 | 50485840 |
| Pneumonia | 12.14 | 11.95 | 485 | 50976 | 377916 | 50175747 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product quality issue | 2545.49 | 14.05 | 794 | 21957 | 15101 | 29536675 |
| No adverse event | 2090.63 | 14.05 | 700 | 22051 | 16778 | 29534998 |
| Poor quality device used | 1484.22 | 14.05 | 289 | 22462 | 531 | 29551245 |
| Product dose omission issue | 1018.62 | 14.05 | 728 | 22023 | 95655 | 29456121 |
| Product container issue | 412.20 | 14.05 | 95 | 22656 | 502 | 29551274 |
| Asthma | 405.37 | 14.05 | 277 | 22474 | 33572 | 29518204 |
| Device malfunction | 320.54 | 14.05 | 148 | 22603 | 8359 | 29543417 |
| Circumstance or information capable of leading to medication error | 284.73 | 14.05 | 86 | 22665 | 1438 | 29550338 |
| Wheezing | 264.87 | 14.05 | 213 | 22538 | 33027 | 29518749 |
| Dyspnoea | 128.50 | 14.05 | 543 | 22208 | 326189 | 29225587 |
| Cough | 126.66 | 14.05 | 292 | 22459 | 126435 | 29425341 |
| Nasal polyps | 113.84 | 14.05 | 45 | 22706 | 1724 | 29550052 |
| Nasal congestion | 113.47 | 14.05 | 103 | 22648 | 18776 | 29533000 |
| Obstructive airways disorder | 112.71 | 14.05 | 82 | 22669 | 10934 | 29540842 |
| Infective pulmonary exacerbation of cystic fibrosis | 101.53 | 14.05 | 62 | 22689 | 6174 | 29545602 |
| Chest discomfort | 96.62 | 14.05 | 146 | 22605 | 45837 | 29505939 |
| Sinusitis | 77.79 | 14.05 | 113 | 22638 | 34237 | 29517539 |
| Full blood count abnormal | 75.09 | 14.05 | 74 | 22677 | 14939 | 29536837 |
| Chronic sinusitis | 71.45 | 14.05 | 32 | 22719 | 1679 | 29550097 |
| Toxicity to various agents | 70.40 | 14.05 | 23 | 22728 | 173638 | 29378138 |
| Poor quality product administered | 66.71 | 14.05 | 30 | 22721 | 1589 | 29550187 |
| Steroid withdrawal syndrome | 65.62 | 14.05 | 18 | 22733 | 209 | 29551567 |
| Incorrect dose administered | 64.02 | 14.05 | 101 | 22650 | 32883 | 29518893 |
| Productive cough | 61.06 | 14.05 | 96 | 22655 | 31163 | 29520613 |
| Sleep disorder due to a general medical condition | 60.95 | 14.05 | 35 | 22716 | 3111 | 29548665 |
| Upper-airway cough syndrome | 59.76 | 14.05 | 34 | 22717 | 2969 | 29548807 |
| Acute kidney injury | 59.57 | 14.05 | 70 | 22681 | 265197 | 29286579 |
| Nasal discomfort | 58.17 | 14.05 | 25 | 22726 | 1187 | 29550589 |
| Death | 55.99 | 14.05 | 112 | 22639 | 341972 | 29209804 |
| Completed suicide | 54.10 | 14.05 | 4 | 22747 | 90242 | 29461534 |
| Rhinitis perennial | 52.58 | 14.05 | 15 | 22736 | 203 | 29551573 |
| Painful respiration | 49.16 | 14.05 | 22 | 22729 | 1152 | 29550624 |
| Fractional exhaled nitric oxide increased | 48.50 | 14.05 | 16 | 22735 | 360 | 29551416 |
| Drug abuse | 46.60 | 14.05 | 4 | 22747 | 79879 | 29471897 |
| Underdose | 45.90 | 14.05 | 51 | 22700 | 11818 | 29539958 |
| Neutropenia | 45.86 | 14.05 | 22 | 22729 | 131689 | 29420087 |
| Product taste abnormal | 45.06 | 14.05 | 20 | 22731 | 1027 | 29550749 |
| Forced expiratory volume decreased | 43.32 | 14.05 | 27 | 22724 | 2786 | 29548990 |
| Thrombocytopenia | 43.28 | 14.05 | 25 | 22726 | 134798 | 29416978 |
| Chest injury | 42.00 | 14.05 | 21 | 22730 | 1412 | 29550364 |
| Walking aid user | 41.40 | 14.05 | 21 | 22730 | 1456 | 29550320 |
| Oropharyngeal discomfort | 40.55 | 14.05 | 25 | 22726 | 2531 | 29549245 |
| Nasopharyngitis | 40.39 | 14.05 | 119 | 22632 | 59546 | 29492230 |
| Bronchopulmonary aspergillosis allergic | 39.83 | 14.05 | 15 | 22736 | 503 | 29551273 |
| Dyspnoea exertional | 39.56 | 14.05 | 87 | 22664 | 36403 | 29515373 |
| Adrenal suppression | 39.44 | 14.05 | 15 | 22736 | 517 | 29551259 |
| Pleural thickening | 39.18 | 14.05 | 13 | 22738 | 298 | 29551478 |
| Pulmonary function test decreased | 38.12 | 14.05 | 29 | 22722 | 4134 | 29547642 |
| Anaemia | 38 | 14.05 | 60 | 22691 | 200891 | 29350885 |
| Nasal disorder | 36.00 | 14.05 | 19 | 22732 | 1430 | 29550346 |
| Anosmia | 35.52 | 14.05 | 21 | 22730 | 1970 | 29549806 |
| Hypersomnia | 34.54 | 14.05 | 42 | 22709 | 10712 | 29541064 |
| Bronchial obstruction | 33.88 | 14.05 | 18 | 22733 | 1373 | 29550403 |
| Renal failure | 32.69 | 14.05 | 26 | 22725 | 118573 | 29433203 |
| Bronchial wall thickening | 32.56 | 14.05 | 16 | 22735 | 1036 | 29550740 |
| Middle insomnia | 32.05 | 14.05 | 30 | 22721 | 5678 | 29546098 |
| Secretion discharge | 31.41 | 14.05 | 26 | 22725 | 4184 | 29547592 |
| Hypersensitivity | 30.68 | 14.05 | 100 | 22651 | 52803 | 29498973 |
| Myocardial infarction | 30.62 | 14.05 | 24 | 22727 | 110272 | 29441504 |
| Adjustment disorder | 30.32 | 14.05 | 15 | 22736 | 986 | 29550790 |
| Respiratory tract congestion | 30.27 | 14.05 | 28 | 22723 | 5221 | 29546555 |
| Sleep apnoea syndrome | 30.21 | 14.05 | 51 | 22700 | 17548 | 29534228 |
| Plantar fasciitis | 29.59 | 14.05 | 16 | 22735 | 1265 | 29550511 |
| Hyperkalaemia | 28.89 | 14.05 | 6 | 22745 | 61386 | 29490390 |
| Nasal oedema | 27.86 | 14.05 | 10 | 22741 | 292 | 29551484 |
| Tongue dry | 27.65 | 14.05 | 9 | 22742 | 194 | 29551582 |
| Platelet count decreased | 27.54 | 14.05 | 24 | 22727 | 104648 | 29447128 |
| Sensation of foreign body | 27.11 | 14.05 | 17 | 22734 | 1773 | 29550003 |
| Hot flush | 26.74 | 14.05 | 44 | 22707 | 14826 | 29536950 |
| Central obesity | 26.71 | 14.05 | 11 | 22740 | 469 | 29551307 |
| Aortic aneurysm | 26.27 | 14.05 | 28 | 22723 | 6192 | 29545584 |
| Product availability issue | 26.05 | 14.05 | 14 | 22737 | 1093 | 29550683 |
| Skin plaque | 25.53 | 14.05 | 22 | 22729 | 3740 | 29548036 |
| Myoglobin blood increased | 25.42 | 14.05 | 17 | 22734 | 1978 | 29549798 |
| Oral candidiasis | 25.31 | 14.05 | 36 | 22715 | 10686 | 29541090 |
| Sinus polyp | 25.28 | 14.05 | 8 | 22743 | 157 | 29551619 |
| Increased viscosity of upper respiratory secretion | 25.08 | 14.05 | 7 | 22744 | 87 | 29551689 |
| Sputum discoloured | 25.03 | 14.05 | 28 | 22723 | 6535 | 29545241 |
| Off label use | 24.96 | 14.05 | 133 | 22618 | 300667 | 29251109 |
| Temperature intolerance | 23.82 | 14.05 | 19 | 22732 | 2902 | 29548874 |
| Cardio-respiratory arrest | 23.69 | 14.05 | 5 | 22746 | 50596 | 29501180 |
| Dry skin | 23.50 | 14.05 | 54 | 22697 | 23253 | 29528523 |
| Eosinophilic granulomatosis with polyangiitis | 23.12 | 14.05 | 14 | 22737 | 1372 | 29550404 |
| Sitting disability | 23.06 | 14.05 | 7 | 22744 | 119 | 29551657 |
| Chorioretinopathy | 22.84 | 14.05 | 14 | 22737 | 1402 | 29550374 |
| Bronchiolitis | 22.63 | 14.05 | 18 | 22733 | 2737 | 29549039 |
| Cystic fibrosis | 22.17 | 14.05 | 14 | 22737 | 1478 | 29550298 |
| Feeling cold | 21.90 | 14.05 | 31 | 22720 | 9160 | 29542616 |
| Rhinorrhoea | 21.85 | 14.05 | 50 | 22701 | 21469 | 29530307 |
| Incorrect dose administered by product | 21.59 | 14.05 | 5 | 22746 | 27 | 29551749 |
| Leukopenia | 21.14 | 14.05 | 8 | 22743 | 55195 | 29496581 |
| Rhinitis | 21.05 | 14.05 | 22 | 22729 | 4756 | 29547020 |
| Eczema | 21.04 | 14.05 | 38 | 22713 | 13788 | 29537988 |
| Growth retardation | 20.99 | 14.05 | 14 | 22737 | 1622 | 29550154 |
| Wrong technique in device usage process | 20.83 | 14.05 | 12 | 22739 | 1073 | 29550703 |
| Pancytopenia | 20.77 | 14.05 | 20 | 22731 | 83148 | 29468628 |
| Influenza | 20.63 | 14.05 | 75 | 22676 | 41806 | 29509970 |
| Ear infection | 20.32 | 14.05 | 28 | 22723 | 8072 | 29543704 |
| Maple syrup disease | 20.30 | 14.05 | 4 | 22747 | 8 | 29551768 |
| Hepatic function abnormal | 20.29 | 14.05 | 3 | 22748 | 39256 | 29512520 |
| Device dislocation | 20.22 | 14.05 | 21 | 22730 | 4506 | 29547270 |
| Dyspnoea at rest | 20.21 | 14.05 | 18 | 22733 | 3196 | 29548580 |
| Cockroach allergy | 20.01 | 14.05 | 5 | 22746 | 39 | 29551737 |
| Throat irritation | 20.01 | 14.05 | 29 | 22722 | 8756 | 29543020 |
| Dust allergy | 19.95 | 14.05 | 9 | 22742 | 480 | 29551296 |
| Dysphonia | 19.93 | 14.05 | 45 | 22706 | 19151 | 29532625 |
| Multiple organ dysfunction syndrome | 19.81 | 14.05 | 12 | 22739 | 63104 | 29488672 |
| Dermatitis atopic | 19.31 | 14.05 | 15 | 22736 | 2204 | 29549572 |
| Therapeutic product effect incomplete | 19.03 | 14.05 | 70 | 22681 | 39235 | 29512541 |
| Bronchitis | 18.99 | 14.05 | 67 | 22684 | 36801 | 29514975 |
| Bradycardia | 18.56 | 14.05 | 14 | 22737 | 65615 | 29486161 |
| Exostosis | 18.51 | 14.05 | 18 | 22733 | 3571 | 29548205 |
| Polyp | 18.48 | 14.05 | 17 | 22734 | 3148 | 29548628 |
| Blood creatinine increased | 18.45 | 14.05 | 23 | 22728 | 85079 | 29466697 |
| Bronchiectasis | 18.41 | 14.05 | 24 | 22727 | 6561 | 29545215 |
| Skin atrophy | 17.94 | 14.05 | 13 | 22738 | 1721 | 29550055 |
| Sepsis | 17.53 | 14.05 | 54 | 22697 | 142628 | 29409148 |
| Cardiac arrest | 16.67 | 14.05 | 25 | 22726 | 85566 | 29466210 |
| Skin weeping | 16.62 | 14.05 | 6 | 22745 | 178 | 29551598 |
| Seasonal allergy | 16.50 | 14.05 | 20 | 22731 | 5082 | 29546694 |
| Hyperleukocytosis | 16.33 | 14.05 | 12 | 22739 | 1623 | 29550153 |
| Brain natriuretic peptide increased | 16.05 | 14.05 | 18 | 22733 | 4212 | 29547564 |
| Disease progression | 15.88 | 14.05 | 24 | 22727 | 81892 | 29469884 |
| Sneezing | 15.42 | 14.05 | 18 | 22733 | 4396 | 29547380 |
| Aspartate aminotransferase increased | 15.33 | 14.05 | 14 | 22737 | 59711 | 29492065 |
| Confusional state | 15.28 | 14.05 | 49 | 22702 | 127828 | 29423948 |
| Somnolence | 15.07 | 14.05 | 31 | 22720 | 93924 | 29457852 |
| Clumsiness | 14.92 | 14.05 | 11 | 22740 | 1495 | 29550281 |
| Obesity | 14.87 | 14.05 | 27 | 22724 | 9836 | 29541940 |
| Encephalopathy | 14.67 | 14.05 | 3 | 22748 | 31040 | 29520736 |
| Stress | 14.65 | 14.05 | 43 | 22708 | 21447 | 29530329 |
| Coma | 14.64 | 14.05 | 6 | 22745 | 39444 | 29512332 |
| Allergy to animal | 14.61 | 14.05 | 6 | 22745 | 254 | 29551522 |
| Snoring | 14.43 | 14.05 | 14 | 22737 | 2770 | 29549006 |
| Hypotension | 14.43 | 14.05 | 89 | 22662 | 194265 | 29357511 |
| Drug interaction | 14.33 | 14.05 | 91 | 22660 | 197294 | 29354482 |
| Expired product administered | 14.32 | 14.05 | 14 | 22737 | 2797 | 29548979 |
| Pharyngeal paraesthesia | 14.25 | 14.05 | 7 | 22744 | 453 | 29551323 |
| Ear disorder | 14.21 | 14.05 | 10 | 22741 | 1264 | 29550512 |
| Swollen tongue | 14.15 | 14.05 | 30 | 22721 | 12236 | 29539540 |
| Lactic acidosis | 14.13 | 14.05 | 3 | 22748 | 30244 | 29521532 |
| Hypoacusis | 14.08 | 14.05 | 33 | 22718 | 14390 | 29537386 |
| Loss of consciousness | 14.06 | 14.05 | 22 | 22729 | 74034 | 29477742 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Poor quality device used | 2050.53 | 11.33 | 450 | 55833 | 1557 | 64440892 |
| Product quality issue | 1917.58 | 11.33 | 784 | 55499 | 29015 | 64413434 |
| Asthma | 789.59 | 11.33 | 658 | 55625 | 94567 | 64347882 |
| No adverse event | 719.80 | 11.33 | 394 | 55889 | 28167 | 64414282 |
| Product dose omission issue | 572.68 | 11.33 | 774 | 55509 | 193973 | 64248476 |
| Wheezing | 455.06 | 11.33 | 449 | 55834 | 80130 | 64362319 |
| Device malfunction | 451.73 | 11.33 | 246 | 56037 | 17387 | 64425062 |
| Gastrooesophageal reflux disease | 337.68 | 11.33 | 389 | 55894 | 82754 | 64359695 |
| Circumstance or information capable of leading to medication error | 325.45 | 11.33 | 119 | 56164 | 3221 | 64439228 |
| Cough | 263.78 | 11.33 | 715 | 55568 | 301433 | 64141016 |
| Product container issue | 260.73 | 11.33 | 74 | 56209 | 857 | 64441592 |
| Sputum discoloured | 223.77 | 11.33 | 158 | 56125 | 17698 | 64424751 |
| Productive cough | 208.54 | 11.33 | 287 | 55996 | 72916 | 64369533 |
| Infective pulmonary exacerbation of cystic fibrosis | 205.04 | 11.33 | 128 | 56155 | 11668 | 64430781 |
| Ejection fraction | 204.07 | 11.33 | 66 | 56217 | 1220 | 64441229 |
| Dyspnoea | 196.42 | 11.33 | 1181 | 55102 | 717493 | 63724956 |
| Sleep disorder due to a general medical condition | 194.68 | 11.33 | 109 | 56174 | 8125 | 64434324 |
| Toxicity to various agents | 190.97 | 11.33 | 42 | 56241 | 363471 | 64078978 |
| Nasal congestion | 185.32 | 11.33 | 244 | 56039 | 59414 | 64383035 |
| Completed suicide | 176.59 | 11.33 | 4 | 56279 | 224410 | 64218039 |
| Nasal polyps | 175.13 | 11.33 | 78 | 56205 | 3551 | 64438898 |
| Rhinitis allergic | 167.07 | 11.33 | 98 | 56185 | 7980 | 64434469 |
| Pleural thickening | 162.80 | 11.33 | 68 | 56215 | 2642 | 64439807 |
| Polycystic ovaries | 153.15 | 11.33 | 61 | 56222 | 2094 | 64440355 |
| Sensitisation | 151.48 | 11.33 | 57 | 56226 | 1674 | 64440775 |
| Steroid withdrawal syndrome | 148.04 | 11.33 | 44 | 56239 | 606 | 64441843 |
| Presbyacusis | 142.66 | 11.33 | 61 | 56222 | 2514 | 64439935 |
| Full blood count abnormal | 140.94 | 11.33 | 151 | 56132 | 29606 | 64412843 |
| Chest discomfort | 136.15 | 11.33 | 308 | 55975 | 115798 | 64326651 |
| Obstructive airways disorder | 134.04 | 11.33 | 131 | 56152 | 23054 | 64419395 |
| Acute kidney injury | 124.78 | 11.33 | 125 | 56158 | 449115 | 63993334 |
| Pneumonia aspiration | 119.71 | 11.33 | 198 | 56085 | 59073 | 64383376 |
| Pleural fibrosis | 119.17 | 11.33 | 62 | 56221 | 3988 | 64438461 |
| Blood magnesium increased | 105.33 | 11.33 | 53 | 56230 | 3178 | 64439271 |
| Blood test abnormal | 104.01 | 11.33 | 88 | 56195 | 12855 | 64429594 |
| Deafness neurosensory | 95.50 | 11.33 | 63 | 56220 | 6311 | 64436138 |
| Drug abuse | 94.92 | 11.33 | 5 | 56278 | 132369 | 64310080 |
| Sleep apnoea syndrome | 86.45 | 11.33 | 118 | 56165 | 29714 | 64412735 |
| Neutropenia | 84.96 | 11.33 | 52 | 56231 | 239572 | 64202877 |
| Epigastric discomfort | 84.69 | 11.33 | 60 | 56223 | 6751 | 64435698 |
| Death | 82.86 | 11.33 | 187 | 56096 | 482518 | 63959931 |
| Thrombocytopenia | 81.55 | 11.33 | 47 | 56236 | 223754 | 64218695 |
| Forced expiratory volume decreased | 79.68 | 11.33 | 58 | 56225 | 6809 | 64435640 |
| Therapeutic product effect incomplete | 79.29 | 11.33 | 234 | 56049 | 103248 | 64339201 |
| Cyst | 79.12 | 11.33 | 73 | 56210 | 11954 | 64430495 |
| Sinusitis | 77.08 | 11.33 | 291 | 55992 | 145637 | 64296812 |
| Synovitis | 73.45 | 11.33 | 3 | 56280 | 99087 | 64343362 |
| Anaemia | 73.16 | 11.33 | 137 | 56146 | 378543 | 64063906 |
| Headache | 71.76 | 11.33 | 741 | 55542 | 528726 | 63913723 |
| Bone cyst | 71.50 | 11.33 | 36 | 56247 | 2161 | 64440288 |
| Nasopharyngitis | 66.22 | 11.33 | 342 | 55941 | 195731 | 64246718 |
| Bronchopulmonary aspergillosis allergic | 66.11 | 11.33 | 31 | 56252 | 1591 | 64440858 |
| Product taste abnormal | 65.71 | 11.33 | 33 | 56250 | 1970 | 64440479 |
| Dry eye | 64.10 | 11.33 | 101 | 56182 | 28918 | 64413531 |
| Bronchiectasis | 63.87 | 11.33 | 70 | 56213 | 14070 | 64428379 |
| Middle insomnia | 62.11 | 11.33 | 66 | 56217 | 12811 | 64429638 |
| Osteopenia | 61.80 | 11.33 | 72 | 56211 | 15468 | 64426981 |
| Upper-airway cough syndrome | 61.15 | 11.33 | 55 | 56228 | 8715 | 64433734 |
| Overdose | 58.83 | 11.33 | 33 | 56250 | 159533 | 64282916 |
| Sleep disorder | 58.70 | 11.33 | 148 | 56135 | 59561 | 64382888 |
| Eosinophilic granulomatosis with polyangiitis | 57.06 | 11.33 | 34 | 56249 | 2848 | 64439601 |
| Skin weeping | 56.25 | 11.33 | 21 | 56262 | 603 | 64441846 |
| Osteosclerosis | 56.01 | 11.33 | 36 | 56247 | 3450 | 64438999 |
| Cardio-respiratory arrest | 54.41 | 11.33 | 10 | 56273 | 98383 | 64344066 |
| Hyperkalaemia | 54.40 | 11.33 | 11 | 56272 | 101118 | 64341331 |
| Rhinorrhoea | 54.17 | 11.33 | 144 | 56139 | 59825 | 64382624 |
| Drug interaction | 53.72 | 11.33 | 151 | 56132 | 361932 | 64080517 |
| Asthenopia | 53.62 | 11.33 | 29 | 56254 | 2018 | 64440431 |
| Off label use | 53.27 | 11.33 | 329 | 55954 | 632477 | 63809972 |
| Adrenal suppression | 52.97 | 11.33 | 25 | 56258 | 1302 | 64441147 |
| Cardiac arrest | 52.43 | 11.33 | 35 | 56248 | 154029 | 64288420 |
| Bronchial obstruction | 52.27 | 11.33 | 30 | 56253 | 2344 | 64440105 |
| Pulmonary function test decreased | 52.06 | 11.33 | 44 | 56239 | 6417 | 64436032 |
| Wrong technique in device usage process | 51.92 | 11.33 | 32 | 56251 | 2850 | 64439599 |
| Incorrect dose administered | 49.99 | 11.33 | 141 | 56142 | 60624 | 64381825 |
| Bronchitis | 49.46 | 11.33 | 207 | 56076 | 108536 | 64333913 |
| Nephrectomy | 48.34 | 11.33 | 24 | 56259 | 1398 | 64441051 |
| Pancytopenia | 48.17 | 11.33 | 33 | 56250 | 143276 | 64299173 |
| Oropharyngeal pain | 47.54 | 11.33 | 178 | 56105 | 88689 | 64353760 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 47.40 | 11.33 | 22 | 56261 | 1103 | 64441346 |
| Leukopenia | 46.80 | 11.33 | 15 | 56268 | 101227 | 64341222 |
| Total lung capacity increased | 46.72 | 11.33 | 19 | 56264 | 689 | 64441760 |
| Carpal tunnel syndrome | 46.44 | 11.33 | 63 | 56220 | 15765 | 64426684 |
| Exostosis | 45.49 | 11.33 | 53 | 56230 | 11385 | 64431064 |
| Rhinitis perennial | 45.45 | 11.33 | 14 | 56269 | 219 | 64442230 |
| Chronic sinusitis | 44.94 | 11.33 | 40 | 56243 | 6252 | 64436197 |
| Platelet count decreased | 43.82 | 11.33 | 49 | 56234 | 167662 | 64274787 |
| Loss of personal independence in daily activities | 43.75 | 11.33 | 151 | 56132 | 72303 | 64370146 |
| Multiple organ dysfunction syndrome | 43.50 | 11.33 | 17 | 56266 | 101396 | 64341053 |
| Nasal oedema | 43.36 | 11.33 | 20 | 56263 | 988 | 64441461 |
| Hand deformity | 43.09 | 11.33 | 3 | 56280 | 62768 | 64379681 |
| Eczema | 43.06 | 11.33 | 86 | 56197 | 29634 | 64412815 |
| Systemic lupus erythematosus | 42.67 | 11.33 | 8 | 56275 | 77604 | 64364845 |
| Respiratory tract congestion | 42.45 | 11.33 | 61 | 56222 | 16104 | 64426345 |
| Intentional overdose | 42.15 | 11.33 | 13 | 56270 | 89931 | 64352518 |
| Metabolic acidosis | 41.94 | 11.33 | 6 | 56277 | 70952 | 64371497 |
| Anosmia | 41.72 | 11.33 | 33 | 56250 | 4384 | 64438065 |
| Respiration abnormal | 40.90 | 11.33 | 38 | 56245 | 6277 | 64436172 |
| Nasal mucosal disorder | 40.26 | 11.33 | 14 | 56269 | 326 | 64442123 |
| Hypotension | 39.80 | 11.33 | 184 | 56099 | 380790 | 64061659 |
| Hypersensitivity | 39.46 | 11.33 | 300 | 55983 | 196152 | 64246297 |
| Confusional state | 39.37 | 11.33 | 108 | 56175 | 261036 | 64181413 |
| Renal failure | 39.37 | 11.33 | 61 | 56222 | 181627 | 64260822 |
| Heart sounds | 39.16 | 11.33 | 16 | 56267 | 587 | 64441862 |
| Bradycardia | 38.70 | 11.33 | 28 | 56255 | 118191 | 64324258 |
| Rhinitis | 38.08 | 11.33 | 47 | 56236 | 10718 | 64431731 |
| Nasal discomfort | 38.04 | 11.33 | 31 | 56252 | 4297 | 64438152 |
| Painful respiration | 37.98 | 11.33 | 27 | 56256 | 3054 | 64439395 |
| Prolonged expiration | 37.51 | 11.33 | 17 | 56266 | 806 | 64441643 |
| Dyspnoea exertional | 37.22 | 11.33 | 145 | 56138 | 73585 | 64368864 |
| Deformity | 37.17 | 11.33 | 36 | 56247 | 6261 | 64436188 |
| Incorrect dose administered by product | 36.97 | 11.33 | 11 | 56272 | 152 | 64442297 |
| Poor quality product administered | 36.95 | 11.33 | 27 | 56256 | 3188 | 64439261 |
| Coma | 36.92 | 11.33 | 163 | 56120 | 87452 | 64354997 |
| Lactic acidosis | 36.75 | 11.33 | 5 | 56278 | 61405 | 64381044 |
| General physical health deterioration | 35.13 | 11.33 | 79 | 56204 | 204346 | 64238103 |
| Respiratory arrest | 35.05 | 11.33 | 3 | 56280 | 52982 | 64389467 |
| Sinus disorder | 34.81 | 11.33 | 57 | 56226 | 16851 | 64425598 |
| Dust allergy | 33.52 | 11.33 | 17 | 56266 | 1036 | 64441413 |
| Contraindicated product administered | 33.43 | 11.33 | 27 | 56256 | 107802 | 64334647 |
| Septic shock | 33.19 | 11.33 | 26 | 56257 | 105411 | 64337038 |
| Increased viscosity of upper respiratory secretion | 32.70 | 11.33 | 11 | 56272 | 231 | 64442218 |
| Sepsis | 31.98 | 11.33 | 99 | 56184 | 230242 | 64212207 |
| Influenza | 31.97 | 11.33 | 180 | 56103 | 106351 | 64336098 |
| Bronchial wall thickening | 31.40 | 11.33 | 20 | 56263 | 1887 | 64440562 |
| Cystic fibrosis | 31.04 | 11.33 | 25 | 56258 | 3409 | 64439040 |
| Bone marrow failure | 30.95 | 11.33 | 3 | 56280 | 47949 | 64394500 |
| Glossodynia | 30.95 | 11.33 | 9 | 56274 | 64687 | 64377762 |
| Underdose | 30.76 | 11.33 | 69 | 56214 | 25760 | 64416689 |
| Urticaria | 30.71 | 11.33 | 227 | 56056 | 147090 | 64295359 |
| Blood potassium increased | 30.49 | 11.33 | 69 | 56214 | 25911 | 64416538 |
| Burning sensation | 30.41 | 11.33 | 104 | 56179 | 49560 | 64392889 |
| Skin plaque | 29.98 | 11.33 | 38 | 56245 | 8902 | 64433547 |
| Hepatic failure | 29.84 | 11.33 | 6 | 56277 | 55388 | 64387061 |
| Palpitations | 29.69 | 11.33 | 174 | 56109 | 104314 | 64338135 |
| Croup infectious | 29.56 | 11.33 | 13 | 56270 | 574 | 64441875 |
| Skin lesion | 29.36 | 11.33 | 84 | 56199 | 36398 | 64406051 |
| Skin burning sensation | 29.36 | 11.33 | 41 | 56242 | 10542 | 64431907 |
| Product administered to patient of inappropriate age | 28.48 | 11.33 | 27 | 56256 | 4574 | 64437875 |
| Nasal disorder | 28.22 | 11.33 | 22 | 56261 | 2862 | 64439587 |
| Febrile neutropenia | 27.23 | 11.33 | 79 | 56204 | 187578 | 64254871 |
| Throat irritation | 26.99 | 11.33 | 76 | 56207 | 32635 | 64409814 |
| Chest injury | 26.98 | 11.33 | 20 | 56263 | 2413 | 64440036 |
| Neutrophil count decreased | 26.98 | 11.33 | 17 | 56266 | 77179 | 64365270 |
| International normalised ratio increased | 26.90 | 11.33 | 18 | 56265 | 79149 | 64363300 |
| Disease progression | 26.64 | 11.33 | 52 | 56231 | 141628 | 64300821 |
| Haemoglobin decreased | 26.26 | 11.33 | 85 | 56198 | 194978 | 64247471 |
| Seasonal allergy | 26.15 | 11.33 | 41 | 56242 | 11685 | 64430764 |
| Dry skin | 26.13 | 11.33 | 101 | 56182 | 51060 | 64391389 |
| Temperature intolerance | 25.97 | 11.33 | 34 | 56249 | 8221 | 64434228 |
| Pericarditis | 25.96 | 11.33 | 11 | 56272 | 62505 | 64379944 |
| Seizure | 25.90 | 11.33 | 68 | 56215 | 166824 | 64275625 |
| Rales | 25.67 | 11.33 | 47 | 56236 | 15182 | 64427267 |
| Swelling face | 25.62 | 11.33 | 111 | 56172 | 59055 | 64383394 |
| Diaphragmatic rupture | 25.39 | 11.33 | 9 | 56274 | 222 | 64442227 |
| Osteoarthritis | 25.30 | 11.33 | 116 | 56167 | 63220 | 64379229 |
| Skin atrophy | 25.13 | 11.33 | 26 | 56257 | 4894 | 64437555 |
| Encephalopathy | 24.99 | 11.33 | 10 | 56273 | 58809 | 64383640 |
| Cardiac disorder | 24.39 | 11.33 | 105 | 56178 | 55711 | 64386738 |
| Acquired haemophilia | 24.24 | 11.33 | 16 | 56267 | 1604 | 64440845 |
| Hyponatraemia | 24.13 | 11.33 | 59 | 56224 | 148280 | 64294169 |
| Hepatic function abnormal | 24.12 | 11.33 | 13 | 56270 | 64300 | 64378149 |
| Interstitial lung disease | 23.97 | 11.33 | 30 | 56253 | 97702 | 64344747 |
| Vomiting | 23.90 | 11.33 | 338 | 55945 | 550779 | 63891670 |
| Swollen tongue | 23.90 | 11.33 | 76 | 56207 | 34878 | 64407571 |
| Ejection fraction abnormal | 23.71 | 11.33 | 15 | 56268 | 1398 | 64441051 |
| Condition aggravated | 23.40 | 11.33 | 210 | 56073 | 372216 | 64070233 |
| Total lung capacity decreased | 23.35 | 11.33 | 16 | 56267 | 1706 | 64440743 |
| Breast cancer | 23.34 | 11.33 | 67 | 56216 | 29081 | 64413368 |
| Type 2 diabetes mellitus | 23.29 | 11.33 | 74 | 56209 | 33946 | 64408503 |
| Shock | 23.15 | 11.33 | 3 | 56280 | 38237 | 64404212 |
| Dehydration | 23.01 | 11.33 | 104 | 56179 | 216659 | 64225790 |
| Fibromyalgia | 22.91 | 11.33 | 76 | 56207 | 35655 | 64406794 |
| Hypersomnia | 22.73 | 11.33 | 52 | 56231 | 19665 | 64422784 |
| Product availability issue | 22.59 | 11.33 | 17 | 56266 | 2099 | 64440350 |
| Cytomegalovirus infection | 22.32 | 11.33 | 3 | 56280 | 37196 | 64405253 |
| Sneezing | 21.93 | 11.33 | 44 | 56239 | 15207 | 64427242 |
| Enthesopathy | 21.91 | 11.33 | 34 | 56249 | 9604 | 64432845 |
| Secretion discharge | 21.54 | 11.33 | 38 | 56245 | 11926 | 64430523 |
| Lung perforation | 21.34 | 11.33 | 6 | 56277 | 67 | 64442382 |
| Ascites | 21.19 | 11.33 | 14 | 56269 | 61987 | 64380462 |
| Helicobacter infection | 20.99 | 11.33 | 4 | 56279 | 38358 | 64404091 |
| Central obesity | 20.88 | 11.33 | 14 | 56269 | 1441 | 64441008 |
| Dermatitis atopic | 20.73 | 11.33 | 21 | 56262 | 3855 | 64438594 |
| Sitting disability | 20.72 | 11.33 | 7 | 56276 | 149 | 64442300 |
| Altered state of consciousness | 20.63 | 11.33 | 4 | 56279 | 37898 | 64404551 |
| CFTR gene mutation | 20.57 | 11.33 | 6 | 56277 | 77 | 64442372 |
| Aortic aneurysm | 20.50 | 11.33 | 29 | 56254 | 7545 | 64434904 |
| Sinus congestion | 20.38 | 11.33 | 43 | 56240 | 15396 | 64427053 |
| Mucosal inflammation | 20.24 | 11.33 | 15 | 56268 | 62569 | 64379880 |
| Adiposis dolorosa | 20.18 | 11.33 | 8 | 56275 | 271 | 64442178 |
| Cockroach allergy | 20.10 | 11.33 | 6 | 56277 | 84 | 64442365 |
| Oropharyngeal discomfort | 20.02 | 11.33 | 24 | 56259 | 5311 | 64437138 |
| Somnolence | 19.89 | 11.33 | 268 | 56015 | 203377 | 64239072 |
| Therapy non-responder | 19.80 | 11.33 | 17 | 56266 | 65882 | 64376567 |
| Maple syrup disease | 19.79 | 11.33 | 4 | 56279 | 8 | 64442441 |
| Cardiac failure | 19.73 | 11.33 | 55 | 56228 | 132318 | 64310131 |
| Gastrointestinal haemorrhage | 19.70 | 11.33 | 55 | 56228 | 132257 | 64310192 |
| Rhabdomyolysis | 19.66 | 11.33 | 31 | 56252 | 91695 | 64350754 |
| Blood immunoglobulin E decreased | 19.65 | 11.33 | 6 | 56277 | 91 | 64442358 |
| Circulatory collapse | 19.59 | 11.33 | 3 | 56280 | 33729 | 64408720 |
| Suicide attempt | 19.36 | 11.33 | 20 | 56263 | 70987 | 64371462 |
| Procedural anxiety | 19.28 | 11.33 | 10 | 56273 | 639 | 64441810 |
| Genital rash | 19.18 | 11.33 | 11 | 56272 | 858 | 64441591 |
| Maternal exposure during pregnancy | 19.08 | 11.33 | 34 | 56249 | 95850 | 64346599 |
| Sarcoidosis | 18.85 | 11.33 | 25 | 56258 | 6121 | 64436328 |
| Hepatocellular injury | 18.71 | 11.33 | 8 | 56275 | 45227 | 64397222 |
| Hospitalisation | 18.68 | 11.33 | 121 | 56162 | 75086 | 64367363 |
| C-reactive protein increased | 18.57 | 11.33 | 34 | 56249 | 94875 | 64347574 |
| Drug resistance | 18.49 | 11.33 | 4 | 56279 | 35098 | 64407351 |
| Respiratory tract infection | 18.41 | 11.33 | 73 | 56210 | 37334 | 64405115 |
| Hypomagnesaemia | 18.25 | 11.33 | 5 | 56278 | 37371 | 64405078 |
| Dystrophic calcification | 18.01 | 11.33 | 6 | 56277 | 122 | 64442327 |
| Depressed level of consciousness | 17.95 | 11.33 | 27 | 56256 | 81409 | 64361040 |
| Electrocardiogram QT prolonged | 17.85 | 11.33 | 26 | 56257 | 79422 | 64363027 |
| Expired product administered | 17.82 | 11.33 | 24 | 56259 | 5963 | 64436486 |
| Skin wrinkling | 17.76 | 11.33 | 11 | 56272 | 988 | 64441461 |
| Erythema marginatum | 17.76 | 11.33 | 4 | 56279 | 16 | 64442433 |
| Drug reaction with eosinophilia and systemic symptoms | 17.53 | 11.33 | 13 | 56270 | 54204 | 64388245 |
| Delirium | 17.22 | 11.33 | 21 | 56262 | 69173 | 64373276 |
| Bursitis | 16.83 | 11.33 | 49 | 56234 | 21436 | 64421013 |
| Feeling cold | 16.66 | 11.33 | 52 | 56231 | 23626 | 64418823 |
| Lung opacity | 16.51 | 11.33 | 17 | 56266 | 3182 | 64439267 |
| Blood pressure increased | 16.40 | 11.33 | 226 | 56057 | 172326 | 64270123 |
| Depressed mood | 16.29 | 11.33 | 75 | 56208 | 40937 | 64401512 |
| Cardiac murmur | 16.20 | 11.33 | 33 | 56250 | 11530 | 64430919 |
| Cardiac failure congestive | 16.14 | 11.33 | 59 | 56224 | 130521 | 64311928 |
| Hypothyroidism | 16.08 | 11.33 | 74 | 56209 | 40383 | 64402066 |
| Intentional self-injury | 15.95 | 11.33 | 3 | 56280 | 29041 | 64413408 |
| Tongue pruritus | 15.89 | 11.33 | 8 | 56275 | 480 | 64441969 |
| Cerebral infarction | 15.83 | 11.33 | 8 | 56275 | 41036 | 64401413 |
| Tarsal tunnel syndrome | 15.63 | 11.33 | 8 | 56275 | 497 | 64441952 |
| Ureteral disorder | 15.63 | 11.33 | 8 | 56275 | 497 | 64441952 |
| Anxiety | 15.60 | 11.33 | 256 | 56027 | 202393 | 64240056 |
| Purpura senile | 15.54 | 11.33 | 8 | 56275 | 503 | 64441946 |
| Fall | 15.54 | 11.33 | 263 | 56020 | 416563 | 64025886 |
| Arrhythmia | 15.49 | 11.33 | 14 | 56269 | 52930 | 64389519 |
| Growth retardation | 15.47 | 11.33 | 12 | 56271 | 1549 | 64440900 |
| Walking aid user | 15.47 | 11.33 | 23 | 56260 | 6258 | 64436191 |
| Oral candidiasis | 15.44 | 11.33 | 50 | 56233 | 23162 | 64419287 |
| Coronary artery disease | 15.40 | 11.33 | 18 | 56265 | 60415 | 64382034 |
| Orthostatic hypotension | 15.38 | 11.33 | 11 | 56272 | 46727 | 64395722 |
| Dyspnoea at rest | 15.34 | 11.33 | 23 | 56260 | 6306 | 64436143 |
| Tongue dry | 15.26 | 11.33 | 10 | 56273 | 990 | 64441459 |
| Nasal dryness | 15.14 | 11.33 | 17 | 56266 | 3509 | 64438940 |
| Hypokalaemia | 15.12 | 11.33 | 55 | 56228 | 121848 | 64320601 |
| Infusion related reaction | 15.10 | 11.33 | 83 | 56200 | 164384 | 64278065 |
| Dysphonia | 15.00 | 11.33 | 80 | 56203 | 46302 | 64396147 |
| Lower respiratory tract infection | 14.97 | 11.33 | 137 | 56146 | 94477 | 64347972 |
| Skin fragility | 14.73 | 11.33 | 9 | 56274 | 789 | 64441660 |
| Neurotoxicity | 14.69 | 11.33 | 3 | 56280 | 27401 | 64415048 |
| Adrenal insufficiency | 14.57 | 11.33 | 48 | 56235 | 22439 | 64420010 |
| Tenosynovitis | 14.53 | 11.33 | 32 | 56251 | 11801 | 64430648 |
| Myocardial infarction | 14.51 | 11.33 | 85 | 56198 | 165736 | 64276713 |
| Dermatitis allergic | 14.37 | 11.33 | 37 | 56246 | 15072 | 64427377 |
| Nasal discharge discolouration | 14.24 | 11.33 | 12 | 56271 | 1742 | 64440707 |
| Cholestasis | 14.20 | 11.33 | 11 | 56272 | 44861 | 64397588 |
| Burns third degree | 14.19 | 11.33 | 7 | 56276 | 402 | 64442047 |
| Exposure during pregnancy | 14.17 | 11.33 | 29 | 56254 | 77646 | 64364803 |
| Bronchial irritation | 14.12 | 11.33 | 4 | 56279 | 46 | 64442403 |
| Rash macular | 13.97 | 11.33 | 49 | 56234 | 23636 | 64418813 |
| Hearing disability | 13.96 | 11.33 | 4 | 56279 | 48 | 64442401 |
| Chorioretinopathy | 13.80 | 11.33 | 13 | 56270 | 2184 | 64440265 |
| Blood bilirubin increased | 13.76 | 11.33 | 18 | 56265 | 57535 | 64384914 |
| White blood cell count decreased | 13.76 | 11.33 | 81 | 56202 | 157756 | 64284693 |
| Pruritus | 13.63 | 11.33 | 363 | 55920 | 312037 | 64130412 |
| Aphonia | 13.61 | 11.33 | 26 | 56257 | 8671 | 64433778 |
| Stress | 13.60 | 11.33 | 95 | 56188 | 60439 | 64382010 |
| Lacrimation increased | 13.57 | 11.33 | 41 | 56242 | 18305 | 64424144 |
| Skin exfoliation | 13.56 | 11.33 | 76 | 56207 | 44809 | 64397640 |
| Sinus polyp | 13.47 | 11.33 | 7 | 56276 | 449 | 64442000 |
| Impaired healing | 13.38 | 11.33 | 20 | 56263 | 60453 | 64381996 |
| Migraine | 13.29 | 11.33 | 97 | 56186 | 62580 | 64379869 |
| Hypothalamic pituitary adrenal axis suppression | 13.17 | 11.33 | 6 | 56277 | 288 | 64442161 |
| Lichenification | 13.17 | 11.33 | 8 | 56275 | 694 | 64441755 |
| Allergic sinusitis | 13.16 | 11.33 | 7 | 56276 | 471 | 64441978 |
| Eye pruritus | 13.09 | 11.33 | 32 | 56251 | 12627 | 64429822 |
| Loss of consciousness | 13.01 | 11.33 | 76 | 56207 | 148289 | 64294160 |
| Acute myeloid leukaemia | 12.81 | 11.33 | 4 | 56279 | 27459 | 64414990 |
| Diarrhoea | 12.70 | 11.33 | 509 | 55774 | 722195 | 63720254 |
| Drug level increased | 12.70 | 11.33 | 7 | 56276 | 34189 | 64408260 |
| Coagulopathy | 12.65 | 11.33 | 6 | 56277 | 31914 | 64410535 |
| Ear infection | 12.60 | 11.33 | 47 | 56236 | 23357 | 64419092 |
| Bone hypertrophy | 12.58 | 11.33 | 6 | 56277 | 320 | 64442129 |
| Peritoneal perforation | 12.57 | 11.33 | 5 | 56278 | 171 | 64442278 |
| Hot flush | 12.48 | 11.33 | 76 | 56207 | 46159 | 64396290 |
| Menopause | 12.48 | 11.33 | 11 | 56272 | 1697 | 64440752 |
| Occupational exposure to dust | 12.46 | 11.33 | 3 | 56280 | 17 | 64442432 |
| Flail chest | 12.41 | 11.33 | 4 | 56279 | 73 | 64442376 |
| Choking | 12.38 | 11.33 | 28 | 56255 | 10510 | 64431939 |
| Mesenteric haemorrhage | 12.26 | 11.33 | 4 | 56279 | 76 | 64442373 |
| Lower respiratory tract congestion | 12.24 | 11.33 | 14 | 56269 | 2947 | 64439502 |
| Red blood cell sedimentation rate increased | 12.18 | 11.33 | 6 | 56277 | 31229 | 64411220 |
| Haematocrit decreased | 12.16 | 11.33 | 18 | 56265 | 54637 | 64387812 |
| Periarthritis | 12.10 | 11.33 | 13 | 56270 | 2554 | 64439895 |
| Exposure to allergen | 12.02 | 11.33 | 5 | 56278 | 192 | 64442257 |
| Wound | 11.98 | 11.33 | 31 | 56252 | 76446 | 64366003 |
| Pulmonary eosinophilia | 11.87 | 11.33 | 7 | 56276 | 575 | 64441874 |
| Depressive symptom | 11.85 | 11.33 | 17 | 56266 | 4479 | 64437970 |
| Increased upper airway secretion | 11.84 | 11.33 | 15 | 56268 | 3512 | 64438937 |
| Upper respiratory tract infection | 11.82 | 11.33 | 106 | 56177 | 72679 | 64369770 |
| Chronic obstructive pulmonary disease | 11.81 | 11.33 | 104 | 56179 | 70944 | 64371505 |
| Polyp | 11.76 | 11.33 | 21 | 56262 | 6652 | 64435797 |
| Product odour abnormal | 11.73 | 11.33 | 9 | 56274 | 1144 | 64441305 |
| Respiratory depression | 11.70 | 11.33 | 3 | 56280 | 23440 | 64419009 |
| Clumsiness | 11.60 | 11.33 | 13 | 56270 | 2678 | 64439771 |
| Neutropenic sepsis | 11.57 | 11.33 | 3 | 56280 | 23269 | 64419180 |
| Swelling | 11.56 | 11.33 | 87 | 56196 | 160131 | 64282318 |
| Bronchiolitis | 11.46 | 11.33 | 15 | 56268 | 3626 | 64438823 |
| Viral infection | 11.46 | 11.33 | 62 | 56221 | 36078 | 64406371 |
| Adjustment disorder | 11.39 | 11.33 | 13 | 56270 | 2732 | 64439717 |
| Forced expiratory volume abnormal | 11.35 | 11.33 | 4 | 56279 | 97 | 64442352 |
FDA Adverse Event Reporting System (Pediatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Small for dates baby | 18.00 | 14.89 | 7 | 3 | 2737 | 81931 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AC13 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
| ATC | D07XC03 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, potent, other combinations |
| ATC | R01AD09 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
| ATC | R01AD59 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
| ATC | R03AK09 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
| ATC | R03AK14 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
| ATC | R03AL12 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids |
| ATC | R03BA07 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D018926 | Anti-Allergic Agents |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D003879 | Dermatologic Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:50177 | dermatologic agent |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Lichen simplex chronicus | indication | 53891004 | |
| Allergic rhinitis | indication | 61582004 | |
| Granuloma annulare | indication | 65508009 | DOID:3777 |
| Pruritus ani | indication | 90446007 | |
| Asthma | indication | 195967001 | DOID:2841 |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plaque psoriasis | indication | 200965009 | |
| Scalp psoriasis | indication | 238608008 | |
| Non-allergic asthma | indication | 266361008 | DOID:9360 |
| Pruritus of genital organs | indication | 267802000 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Allergic asthma | indication | 389145006 | DOID:9415 |
| Primary cutaneous T-cell lymphoma | indication | 400122007 | |
| Asthma management | indication | 406162001 | |
| Allergic Rhinitis Prevention | indication | ||
| Chronic Non-Allergic Rhinitis | indication | ||
| Severe chronic obstructive pulmonary disease | off-label use | 313299006 | |
| Mycosis | contraindication | 3218000 | DOID:1564 |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Inactive tuberculosis | contraindication | 11999007 | |
| Epistaxis | contraindication | 12441001 | |
| Asthenia | contraindication | 13791008 | |
| Measles | contraindication | 14189004 | DOID:8622 |
| Disease caused by parasite | contraindication | 17322007 | |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Acute tuberculosis | contraindication | 25629007 | |
| Immunosuppression | contraindication | 38013005 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Varicella | contraindication | 38907003 | DOID:8659 |
| Hypokalemia | contraindication | 43339004 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Skin ulcer | contraindication | 46742003 | |
| Osteoporosis | contraindication | 64859006 | DOID:11476 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hypopituitarism | contraindication | 74728003 | DOID:9406 |
| Perforation of nasal septum | contraindication | 80142000 | |
| Bacterial infectious disease | contraindication | 87628006 | |
| Operation on nose | contraindication | 88733004 | |
| Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
| Fissure in skin | contraindication | 95321009 | |
| Bilateral cataracts | contraindication | 95722004 | |
| Prolonged QT interval | contraindication | 111975006 | |
| Seizure disorder | contraindication | 128613002 | |
| Ophthalmic herpes simplex | contraindication | 186542001 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Telangiectasia disorder | contraindication | 247479008 | |
| Exacerbation of asthma | contraindication | 281239006 | |
| Varicella-zoster virus infection | contraindication | 309465005 | |
| Osteopenia | contraindication | 312894000 | |
| Skin irritation | contraindication | 367466007 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 | |
| Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
| Denuded skin | contraindication | 418242004 | |
| Congenital long QT syndrome | contraindication | 442917000 | |
| Nasal Septal Ulcers | contraindication | ||
| Untreated Fungal Infection | contraindication | ||
| Nasal Trauma | contraindication | ||
| Nasal Candidiasis | contraindication | ||
| Uncontrolled Bacterial Infections | contraindication |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Otitis externa | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Mometamax Otic Suspension | Intervet Inc. | 3 |
| Posatex Otic Suspension | Intervet Inc. | 3 |
| CLARO | Elanco US Inc. | 3 |
| Mometavet | Med-Pharmex Inc. | 3 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.01 | acidic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 7662141 | March 12, 2024 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 7713255 | March 12, 2024 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 7951130 | March 12, 2024 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 7951131 | March 12, 2024 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 7951133 | March 12, 2024 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 8109918 | March 12, 2024 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 9585681 | April 4, 2026 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 7544192 | Nov. 29, 2026 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 8025635 | June 12, 2027 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 10357640 | Oct. 3, 2031 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
| 0.025MG/SPRAY;0.665MG/SPRAY | RYALTRIS | GLENMARK SPECIALTY | N211746 | Jan. 13, 2022 | RX | SPRAY, METERED | NASAL | 10016443 | Sept. 4, 2034 | TREATMENT OF SEASONAL ALLERGIC RHINITIS BY NASALY ADMINISTERING A COMBINATION OF OLOPATADINE HYDROCHLORIDE AND MOMETASONE FUROATE |
| 0.025MG/SPRAY;0.665MG/SPRAY | RYALTRIS | GLENMARK SPECIALTY | N211746 | Jan. 13, 2022 | RX | SPRAY, METERED | NASAL | 10517880 | Sept. 4, 2034 | TREATMENT OF SEASONAL ALLERGIC RHINITIS BY NASALY ADMINISTERING A COMBINATION OF OLOPATADINE HYDROCHLORIDE AND MOMETASONE FUROATE |
| 0.025MG/SPRAY;0.665MG/SPRAY | RYALTRIS | GLENMARK SPECIALTY | N211746 | Jan. 13, 2022 | RX | SPRAY, METERED | NASAL | 10548907 | Sept. 4, 2034 | TREATMENT OF SEASONAL ALLERGIC RHINITIS BY NASALY ADMINISTERING A COMBINATION OF OLOPATADINE HYDROCHLORIDE AND MOMETASONE FUROATE |
| 0.025MG/SPRAY;0.665MG/SPRAY | RYALTRIS | GLENMARK SPECIALTY | N211746 | Jan. 13, 2022 | RX | SPRAY, METERED | NASAL | 10646500 | Sept. 4, 2034 | TREATMENT OF SEASONAL ALLERGIC RHINITIS BY NASALY ADMINISTERING A COMBINATION OF OLOPATADINE HYDROCHLORIDE AND MOMETASONE FUROATE |
| 0.025MG/SPRAY;0.665MG/SPRAY | RYALTRIS | GLENMARK SPECIALTY | N211746 | Jan. 13, 2022 | RX | SPRAY, METERED | NASAL | 10758550 | Sept. 4, 2034 | TREATMENT OF SEASONAL ALLERGIC RHINITIS BY NASALY ADMINISTERING A COMBINATION OF OLOPATADINE HYDROCHLORIDE AND MOMETASONE FUROATE TO A PEDIATRIC PATIENT |
| 0.025MG/SPRAY;0.665MG/SPRAY | RYALTRIS | GLENMARK SPECIALTY | N211746 | Jan. 13, 2022 | RX | SPRAY, METERED | NASAL | 10765686 | Sept. 4, 2034 | METHOD OF DELIVERING A COMBINATION OF OLOPATADINE HYDROCHLORIDE AND MOMETASONE FUROATE TO A NASAL AIRWAY |
| 0.025MG/SPRAY;0.665MG/SPRAY | RYALTRIS | GLENMARK SPECIALTY | N211746 | Jan. 13, 2022 | RX | SPRAY, METERED | NASAL | 9078923 | Sept. 4, 2034 | TREATMENT OF SEASONAL ALLERGIC RHINITIS BY NASALY ADMINISTERING A COMBINATION OF OLOPATADINE HYDROCHLORIDE AND MOMETASONE FUROATE |
| 0.025MG/SPRAY;0.665MG/SPRAY | RYALTRIS | GLENMARK SPECIALTY | N211746 | Jan. 13, 2022 | RX | SPRAY, METERED | NASAL | 9750754 | Sept. 4, 2034 | TREATMENT OF SEASONAL ALLERGIC RHINITIS BY NASALY ADMINISTERING A COMBINATION OF OLOPATADINE HYDROCHLORIDE AND MOMETASONE FUROATE |
| 1.35MG | SINUVA | INTERSECT ENT INC | N209310 | Dec. 8, 2017 | RX | IMPLANT | IMPLANTATION | 10232152 | Nov. 24, 2034 | TREATMENT OF NASAL POLYPS IN PATIENTS >=18 YEARS OF AGE WHO HAVE HAD ETHMOID SINUS SURGERY USING A CORTICOSTEROID-ELUTING (MOMETASONE FUROATE) IMPLANT |
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 0.005MG/INH;0.05MG/INH | DULERA | ORGANON | N022518 | Aug. 12, 2019 | RX | AEROSOL, METERED | INHALATION | Aug. 12, 2022 | NEW STRENGTH |
| 0.05MG/INH | ASMANEX HFA | ORGANON | N205641 | Aug. 12, 2019 | RX | AEROSOL, METERED | INHALATION | Aug. 12, 2022 | NEW STRENGTH |
| 0.005MG/INH;0.05MG/INH | DULERA | ORGANON | N022518 | Aug. 12, 2019 | RX | AEROSOL, METERED | INHALATION | Feb. 12, 2023 | PEDIATRIC EXCLUSIVITY |
| 0.05MG/INH | ASMANEX HFA | ORGANON | N205641 | Aug. 12, 2019 | RX | AEROSOL, METERED | INHALATION | Feb. 12, 2023 | PEDIATRIC EXCLUSIVITY |
| 0.025MG/SPRAY;0.665MG/SPRAY | RYALTRIS | GLENMARK SPECIALTY | N211746 | Jan. 13, 2022 | RX | SPRAY, METERED | NASAL | Jan. 13, 2025 | NEW PRODUCT |
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | Ki | 9.15 | CHEMBL | CHEMBL | |||
| Multidrug resistance protein 1 | Transporter | IC50 | 6.13 | WOMBAT-PK | |||||
| Progesterone receptor | Nuclear hormone receptor | EC50 | 9.90 | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4019844 | VUID |
| N0000147931 | NUI |
| D00690 | KEGG_DRUG |
| 4019367 | VANDF |
| 4019844 | VANDF |
| 4021125 | VANDF |
| C0066700 | UMLSCUI |
| CHEBI:47564 | CHEBI |
| CHEBI:6970 | CHEBI |
| MOF | PDB_CHEM_ID |
| CHEMBL1161 | ChEMBL_ID |
| D000068656 | MESH_DESCRIPTOR_UI |
| DB14512 | DRUGBANK_ID |
| 9029 | IUPHAR_LIGAND_ID |
| 141646-00-6 | SECONDARY_CAS_RN |
| 105102-22-5 | SECONDARY_CAS_RN |
| 04201GDN4R | UNII |
| 441336 | PUBCHEM_CID |
| 441335 | PUBCHEM_CID |
| DB00764 | DRUGBANK_ID |
| 108118 | RXNORM |
| 11404 | MMSL |
| 239640 | MMSL |
| 5129 | MMSL |
| 5130 | MMSL |
| d05262 | MMSL |
| 002205 | NDDF |
| 395802006 | SNOMEDCT_US |
| 395803001 | SNOMEDCT_US |
| 395990009 | SNOMEDCT_US |
| 75203002 | SNOMEDCT_US |
| C0360564 | UMLSCUI |
| 6030 | INN_ID |
| 8HR4QJ6DW8 | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Dulera | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0085-4610 | AEROSOL | 200 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
| Dulera | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0085-7206 | AEROSOL | 100 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0270 | CREAM | 1 mg | TOPICAL | ANDA | 28 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0271 | OINTMENT | 1 mg | TOPICAL | ANDA | 28 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0272 | SOLUTION | 1 mg | TOPICAL | ANDA | 29 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0634 | CREAM | 1 mg | TOPICAL | ANDA | 27 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0634 | CREAM | 1 mg | TOPICAL | ANDA | 27 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0635 | OINTMENT | 1 mg | TOPICAL | ANDA | 24 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0701 | SOLUTION | 1 mg | TOPICAL | ANDA | 27 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0726 | CREAM | 1 mg | TOPICAL | ANDA | 27 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0726 | CREAM | 1 mg | TOPICAL | ANDA | 27 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0727 | OINTMENT | 1 mg | TOPICAL | ANDA | 24 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0727 | OINTMENT | 1 mg | TOPICAL | ANDA | 24 sections |
| Sinuva | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10599-003 | IMPLANT | 1350 ug | INTRASINAL | NDA | 29 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-527 | OINTMENT | 1 mg | TOPICAL | ANDA | 26 sections |
| MOMETASONE FUROATE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-993 | CREAM | 1 mg | TOPICAL | ANDA | 10 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-974 | CREAM | 1 mg | TOPICAL | ANDA | 27 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-786 | CREAM | 1 mg | TOPICAL | ANDA | 13 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-175 | OINTMENT | 1 mg | TOPICAL | ANDA | 13 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-118 | SOLUTION | 1 mg | TOPICAL | ANDA | 27 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-119 | OINTMENT | 1 mg | TOPICAL | ANDA | 29 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-257 | CREAM | 1 mg | TOPICAL | ANDA | 29 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1026 | OINTMENT | 1 mg | TOPICAL | ANDA | 26 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1633 | OINTMENT | 1 mg | TOPICAL | ANDA | 26 sections |
| Dulera | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-1916 | AEROSOL | 200 ug | RESPIRATORY (INHALATION) | NDA | 29 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2179 | CREAM | 1 mg | TOPICAL | ANDA | 25 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2991 | CREAM | 1 mg | TOPICAL | ANDA | 25 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1305 | SOLUTION | 1 mg | TOPICAL | ANDA | 29 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1305 | SOLUTION | 1 mg | TOPICAL | ANDA | 29 sections |
| Mometasone Furoate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-1311 | OINTMENT | 1 mg | TOPICAL | ANDA | 29 sections |